ACS Sensors最新文献

{"title":"Controlled Assembly of Bimetallic PtRh-Modified Tin Oxide Hollow Nanotubes with High Sensing Activity for Ultrasensitive Formaldehyde Detection","authors":"Ge Wang, Haijie Cai, Jinlei Wei, Xingyu Wang, Xueqing Zhang, Tianjun Ni, Yongheng Zhu","doi":"10.1021/acssensors.5c01094","DOIUrl":"https://doi.org/10.1021/acssensors.5c01094","url":null,"abstract":"Gas sensors for rapid identification of formaldehyde (HCHO) exposure risks are of great significance, given the volatility, toxicity, and near-imperceptibility of HCHO. However, the precise design of highly reactive sensing materials remains a substantial challenge that limits the application of gas sensors. Here, PtRh-modified tin oxide (PtRh/SnO₂) hollow nanotubes with an open hollow nanostructure and bimetallic sensitization are proposed for regulating the reactivity to achieve ideal improvement in HCHO-sensing performance. The prepared 1.5% PtRh/SnO₂ hollow nanotube-based sensor achieves a high sensing response (<i>R</i>_a/<i>R</i>_g = 265.8–25 ppm of HCHO), fast response and recovery rate (2.6 and 6.1 s), good selectivity, and strong anti-interference toward HCHO at 200 °C. Based on the <i>ex</i>/<i>in situ</i> characterizations and density functional theory (DFT) calculations, the enhanced sensing properties are mainly attributed to the construction of hierarchical hollow nanostructures providing sufficient active sites for gas absorption, as well as the oxygen spillover effect from Pt, the catalytic property of Rh, and their synergistic effects. Hence, the architecture demonstrates enhanced adsorption capacity and interfacial reactivity toward HCHO, thereby improving the sensing response and selectivity. In addition, the PtRh/SnO₂ sensor was used to monitor the HCHO in oysters, providing promising applications in real-time aquatic product HCHO monitoring.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"6 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive Quantification of Thyroid-Stimulating Hormone and Thyroxine by Nanoelectronic SnS2 Transistor Sensors.","authors":"Ankur Anand,Feng-Yi Su,Tse-Hao Chen,Yung-Fu Chen,Yit-Tsong Chen","doi":"10.1021/acssensors.5c00115","DOIUrl":"https://doi.org/10.1021/acssensors.5c00115","url":null,"abstract":"The measurement of thyroid hormones in serum is widely regarded as the most valuable single laboratory tool for assessing thyroid function. This study presents a highly sensitive tin disulfide nanosheet-fabricated field-effect transistor (SnS2-FET) designed for the detections of human thyroid-stimulating hormone (hTSH) and thyroxine (T4). By co-modifying an antibody (AbTSH for detecting hTSH), or a DNA aptamer (AptT4 for detecting T4), with polyethylene glycol (PEG) on the SnS2-FET channel surface, the PEG:AbTSH/SnS2-FET and PEG:AptT4/SnS2-FET devices achieve highly sensitive and selective detections of hTSH and T4, respectively, even in a high ionic strength buffer (1× PBS) or undiluted serum. With a low limit of detection (in the femtomolar level) and a wide linear working range (spanning at least 6 orders of magnitude of analyte concentration), the PEG:AbTSH/SnS2-FET immunosensor and PEG:AptT4/SnS2-FET aptasensor can detect the hTSH and T4 levels encountered in the spectrum of thyroid disorders. Notably, these specific receptor-modified SnS2-FET devices display negligible cross-reactivity with other pituitary hormones or serum components. This research indicates that the nanoelectronic SnS2-FET sensor platforms hold significant potential for point-of-care clinical diagnostics, particularly for the ultrasensitive detection and early screening of medical conditions.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"183 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Situ-Synthesized Gold Nanostructures (issAu) to Minimize Storage Constraints in Sensing Applications","authors":"Jun Jiang Luo, Han Yue Liu, Hao Lin Zou, Bang Lin Li","doi":"10.1021/acssensors.5c00928","DOIUrl":"https://doi.org/10.1021/acssensors.5c00928","url":null,"abstract":"Nanoscale gold (Au) materials have garnered significant attention in chemical and biological analyses owing to their exceptional properties. However, their practical applications in sensing nanotechnologies are remarkably constrained by the inherent and universal drawbacks of nanomaterials. For instance, the poor stability of nanomaterials during storage substantially compromises the test repeatability and accuracy. To date, the lack of standardized protocols for the synthesis and storage of nanomaterials remains a critical barrier to the widespread applications of nanotechnologies. Without the storage, in situ-synthesized nanomaterials might offer a promising solution to overcome these storage-related challenges. In this perspective, Au nanostructures are classified into two categories: presynthesized Au (<b>psAu</b>) and in situ-synthesized Au nanostructures (<b>issAu</b>), respectively. Differing from <b>psAu</b>, <b>issAu</b> refers to protocols in which the preparation of Au nanostructures is simultaneously coupled with their concurrent functional applications. While extensive research has been conducted on <b>psAu</b> strategies, recent studies over the past decade have increasingly focused on <b>issAu</b> nanostructures. The <b>issAu</b> concept has exhibited boosted sensing responses and enhanced anti-interference in chemical and biological analysis. Moreover, <b>issAu</b> nanostructures work as intriguing signal probes, showing high potential in time-saving operation and improved selectivity and sensitivity. This perspective outlines the formation routes of <b>issAu</b> nanostructures and provides a comprehensive review of their unique properties and sensing applications. Additionally, a detailed comparison between <b>psAu</b> and <b>issAu</b> materials is correspondingly presented, underscoring the transformative potential of <b>issAu</b> nanostructures and inspiring broader applications of the in situ-synthesis concept for other vital nanomaterials.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"142 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Humidity Resistance and Oxygen-Content Independence of Conductometric Hydrogen Sulfide Sensors Based on Electrospun CeO2/CuO Nanotubes","authors":"Yanjie Wang, Mengqing Wang, Xinke Jiang, Xiaopeng She, Yi Chen, Yin Long, Yong Zhou","doi":"10.1021/acssensors.5c00478","DOIUrl":"https://doi.org/10.1021/acssensors.5c00478","url":null,"abstract":"Limited by inherent physicochemical properties and surface-adsorption-dominated gas-sensing behavior, traditional metal oxides are susceptible to ambient humidity levels and oxygen content within test environments. To overcome this issue, we proposed one highly sensitive MEMS-type H₂S sensor featuring electrospun cerium oxide (CeO₂)/copper oxide (CuO) nanotubes as the sensing layer. The constituent ratio-optimized sensors (CeO₂/CuO-5) exhibited superior H₂S-sensing performance over pure CeO₂ counterparts, including lower operation temperature, more than two times stronger response (7.4 vs 3.1@4 ppm), and favorable selectivity. Density functional theory calculations and a series of characterization methods found that the increased oxygen vacancies and abundant CeO₂/CuO n-p heterojunctions jointly contributed to the promotion of receptor and transducer function. In addition, a humidity-resistant and oxygen content-independent sensor performance was demonstrated. On the one hand, the self-refreshing effect of CeO₂ endowed the CeO₂/CuO-5 sensor with 75.6% retention of response toward 4 ppm of H₂S under 70% RH with respect to the dry case, thus showcasing an excellent humidity tolerance. On the other hand, the decent oxygen storage ability of CeO₂ favored a high response even under oxygen-lean environments. Furthermore, a patrol monitor apparatus loaded with the as-prepared sensor was designed, which showed efficient detection and alerting for on-site H₂S leakage.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"44 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Elucidation of Substrate Effects in Graphene-Based Sensing Characteristics─Interfaces between Organic Solvent and Graphene","authors":"Yu-Xuan Lu, Guan-Ying Chen, Fang-Min Lin, Ming-Hsiu Tsai, Chih-Ting Lin","doi":"10.1021/acssensors.5c01138","DOIUrl":"https://doi.org/10.1021/acssensors.5c01138","url":null,"abstract":"Most graphene-sensor researches have focused on direct graphene modifications to enhance performance. However, supporting-substrate effects on graphene sensing mechanisms remain underexplored. Because of graphene 2D architecture, substrates affect its surface potential, wettability, and molecular adsorption. These effects intensify in the presence of polar molecules, e.g., water molecules, further complicating the sensing characteristics. To explore these effects, this study investigates the influence of substrate on the sensing capabilities and mechanisms of graphene field-effect transistors (GFETs) in organic solvents through electrical-transport measurements. Specifically, we compare partially suspended graphene FETs (PS-GFETs) and oxide-supported graphene FETs (OS-GFETs) in response to dimethyl sulfoxide (DMSO), ethanol, and isopropanol (IPA) at different concentrations. By quantifying Dirac-point hysteresis, we experimentally show that the hysteresis correlates with molecular polarity, following the trend DMSO &lt; ethanol &lt; IPA. Moreover, OS-GFETs exhibit a 1.5-fold sensitivity enhancement compared to PS-GFETs when detecting organic solution concentrations. Employing the two-dimensional hydrogen bond network (2D-HBNS) model, we theoretically illustrate that hydrophobic PS-GFET surfaces maintain equilibrium through hydration shell and 2D-HBNS formation. In contrast, hydrophilic OS-GFET surfaces disrupt this balance, enhancing van der Waals interactions and attracting organic molecules. This leads to superior sensitivity in OS-GFETs. To further validate this hypothesis, we introduced poly(methyl methacrylate) (PMMA) and polytetrafluoroethylene (PTFE) layers on the SiO₂ substrate. The experiments show it changes graphene-surface hydrophilicity and graphene-sensor sensitivity. These findings establish a theoretical and experimental framework for optimizing graphene-based sensors. This framework elucidates a solute–solvent interfacial interaction model for polar liquids, aiming to improve the sensing characteristics of 2D materials.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"35 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humidity-Resistant Pt/CrVN2 Fuel Cell Sensor for H2S Biomarker Detection.","authors":"Zhaorui Zhang,Chonghui Zhu,Yu Liang,Jinkui Chu,Yuxia Shan,Minghui Yang","doi":"10.1021/acssensors.5c01358","DOIUrl":"https://doi.org/10.1021/acssensors.5c01358","url":null,"abstract":"Real-time, remote monitoring of human biomarkers is essential for personalized medical diagnostics. Hydrogen sulfide (H2S), a key endogenous gas, serves as a crucial biomarker for conditions such as oral diseases. However, accurately detecting ppb-level H2S in high-humidity environments remains a challenge. Herein, we develop a Pt-loaded CrVN2 fuel cell-type H2S sensor that exhibits high humidity resistance, ultralow detection limits (50 ppb), rapid response (4 s), and exceptional selectivity. The stable electronic structure of CrVN2 ensures a consistent response across a wide relative humidity range (9%-79%). Furthermore, a wireless detection system incorporating the Pt/CrVN2 sensor was designed and validated for breath diagnosis, demonstrating its practical application in smart healthcare. This study highlights the potential of Pt/CrVN2 sensor as a promising platform for real-time, sensitive biomarker detection, contributing to the advancement of next-generation medical diagnostics.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"45 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “The Cross-Sensitivity of Chemiresistive Gas Sensors: Nature, Methods, and Peculiarities: A Systematic Review”","authors":"Amanzhol Turlybekuly, Yernar Shynybekov, Baktiyar Soltabayev, Gani Yergaliuly, Almagul Mentbayeva","doi":"10.1021/acssensors.5c01638","DOIUrl":"https://doi.org/10.1021/acssensors.5c01638","url":null,"abstract":"This Addition and Correction is issued to correct an important error in one of the equations. Equation 2 in the “Cross-Sensitivity and Interfering Gases” section was changed. In addition, the name for eq 2 was changed from “selectivity” to “cross-sensitivity”. The corrected text and equation are shown below: The cross-sensitivity of the gas sensor is numerically assessed by eq 2⁹ and eq 3¹¹: This article has not yet been cited by other publications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"8 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Single-Impact Electrochemistry Using Silver Nanoparticles as a “Digital” Readout for Biosensing Applications","authors":"Sebastian Freko, Lennart J.K. Weiß, Friedrich C. Simmel, Bernhard Wolfrum","doi":"10.1021/acssensors.5c00064","DOIUrl":"https://doi.org/10.1021/acssensors.5c00064","url":null,"abstract":"Direct single-impact electrochemistry is a rapidly evolving analytical method based on the collision of redox-active species, such as silver nanoparticles (AgNPs), with a biased microelectrode. The collision results in distinct current spikes due to partial or complete oxidation of a particle. In recent years, this technique has been applied in various biosensing strategies as a “digital” readout technique. It offers the quantification of analytes using discrete signals, as opposed to conventional amplitude-based methods. In this review, we explore the latest advancements in direct single-impact electrochemistry for biosensing applications. In addition, we summarize the key factors influencing the “digital” readout performance and their interrelationships, including particle size and corona, electrode size and potential, electrolyte composition, particle mass transport toward the electrode, and data acquisition. Considering recent experimental developments and theoretical principles, we have identified guidelines that are expected to facilitate and accelerate the development of novel direct impact-based sensing platforms, particularly for point-of-care (POC) applications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"42 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuning the Aggregation of Plasmonic Probes to Shed Light on Diagnostic Strategies","authors":"Sungjae Park, Sojeong Lee, Jungwoo Park, Seungjoo Haam, Jungho Hwang","doi":"10.1021/acssensors.5c00113","DOIUrl":"https://doi.org/10.1021/acssensors.5c00113","url":null,"abstract":"Gold nanoparticle (GNP)-based aggregation assays were tuned by systematically varying the length and concentration of the plasmonic probes, which are two critical factors that influence the detection range and sensitivity. Plasmonic probes were engineered by conjugating antibodies to fixed-size GNPs via poly(ethylene glycol) (PEG) linkers of varying molecular weights. The performance of these probes was evaluated in the detection of hemagglutinin (HA) protein, a marker of the influenza A virus, with a focus on the corresponding shifts in localized surface plasmon resonance. The results demonstrated that shorter plasmonic probes exhibited enhanced sensitivity and produced more pronounced colorimetric signals, thereby achieving a broader detection range. Additionally, the probe concentration was critical for modulating the measurable concentration range of the HA protein. Quantitative analysis using the plasmon ruler equation confirmed that the interparticle distance, governed by the probe length and concentration, is a key determinant of assay performance. Our study provides insights into the design of GNP-based diagnostic tools that allow customizable detection ranges tailored to specific applications. These findings suggest that by fine-tuning the plasmonic probe parameters, the balance between sensitivity and detection range can be optimized, offering a versatile approach to the design of point-of-care diagnostic assays.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"12 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Time Single-Particle Tracking of Intracellular pH Dynamics during Ferroptosis Using Plasmonic Core–Satellite Nanostructures","authors":"Hua Liu, Xiulin Fan, Lin Wei, Hui Cai, Lehui Xiao","doi":"10.1021/acssensors.5c01496","DOIUrl":"https://doi.org/10.1021/acssensors.5c01496","url":null,"abstract":"Ferroptosis, an iron-dependent regulated cell death process, is characterized by lysosomal membrane permeabilization and pH dysregulation. Here, we report a DNA-programmed plasmonic nanoprobe based on i-motif-mediated gold core–satellite nanostructures (Au CSNSs) for single-particle resolution mapping of intracellular pH dynamics during ferroptosis. The i-motif DNA linker undergoes pH-dependent conformational switching, dynamically tuning the interparticle gap between 45 nm gold core nanoparticles (Au core NPs) and 15 nm gold satellite nanoparticles (Au satellite NPs). This architecture achieves a large localized surface plasmon resonance (LSPR) shift in the pH range of 5.6–6.8, enabling reversible and linear pH sensing (<i>R</i>² = 0.97) with excellent photostability. During ferroptosis induced by exogenous iron, Au CSNSs displayed rapid spectral shifts corresponding to lysosomal H⁺ leakage, corroborated by acridine orange staining. Notably, mitophagy activation <i>via</i> rapamycin pretreatment sensitized cells to low-dose iron (1 μM), triggering earlier and more pronounced pH changes. This work establishes a novel platform for investigating pH-dependent signaling in ferroptosis, with implications for understanding mitochondria–lysosome crosstalk and developing targeted cancer therapies.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"170 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}