Biomaterials Science最新文献

筛选
英文 中文
MnO2-based nanoparticles remodeling tumor micro-environment to augment sonodynamic immunotherapy against breast cancer. 二氧化锰纳米颗粒重塑肿瘤微环境,增强对乳腺癌的声动力免疫治疗。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-09 DOI: 10.1039/d5bm00189g
Haiqin Liao, Mingyu Chen, Zhipeng Liao, Yi Luo, Sijie Chen, Long Wang, Zhigang Wang, Chengcheng Niu
{"title":"MnO<sub>2</sub>-based nanoparticles remodeling tumor micro-environment to augment sonodynamic immunotherapy against breast cancer.","authors":"Haiqin Liao, Mingyu Chen, Zhipeng Liao, Yi Luo, Sijie Chen, Long Wang, Zhigang Wang, Chengcheng Niu","doi":"10.1039/d5bm00189g","DOIUrl":"https://doi.org/10.1039/d5bm00189g","url":null,"abstract":"<p><p>The tumor microenvironment (TME) is characterized by a complex array of factors, including aerobic conditions, high glutathione (GSH) levels, acidic pH, and elevated hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) content, all of which promote cancer progression and contribute to poor prognosis. Fortunately, these challenges can be addressed using MnO<sub>2</sub>-based nanomaterials. In this study, we have designed and synthesized a Curcumin/MnO<sub>2</sub>@PLGA@4T1 cell membrane (CMP@4T1m) system aimed at remodelling the TME and enhancing sonodynamic immunotherapy for breast cancer. Through the homologous targeting ability of 4T1m, CMP@4T1m efficiently accumulates at the tumor site. Upon ultrasound irradiation, curcumin (Cur) acts as a sonosensitizer, generating cytotoxic reactive oxygen species (ROS) that induce immunogenic cell death (ICD), activate T-cell responses, and repolarize protumoral M2-like macrophages to antitumoral M1-like macrophages. In the TME, which is mildly acidic and enriched with GSH and H<sub>2</sub>O<sub>2</sub>, MnO<sub>2</sub> not only oxidizes GSH to glutathione disulfide (GSSG) but also reacts with H<sub>2</sub>O<sub>2</sub> and H<sup>+</sup> to produce oxygen, alleviating hypoxia and significantly enhancing the sonodynamic immunotherapy effect. Additionally, Mn<sup>2+</sup> generated during this process converts H<sub>2</sub>O<sub>2</sub> into cytotoxic hydroxyl radicals (˙OH). This study thus lays the foundation for advancing cancer nanomedicine, offering a novel approach that integrates TME remodelling with sonodynamic immunotherapy.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostics of brain tumor in the early stage: current status and future perspectives. 脑肿瘤的早期诊断:现状与未来展望
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-09 DOI: 10.1039/d4bm01503g
Muhammad Ijaz, Ikram Hasan, Bilal Aslam, Yuqian Yan, Wenjun Zeng, Jingsi Gu, Jian Jin, Yinghe Zhang, Shaohua Wang, Lu Xing, Bing Guo
{"title":"Diagnostics of brain tumor in the early stage: current status and future perspectives.","authors":"Muhammad Ijaz, Ikram Hasan, Bilal Aslam, Yuqian Yan, Wenjun Zeng, Jingsi Gu, Jian Jin, Yinghe Zhang, Shaohua Wang, Lu Xing, Bing Guo","doi":"10.1039/d4bm01503g","DOIUrl":"https://doi.org/10.1039/d4bm01503g","url":null,"abstract":"<p><p>Early diagnosis of brain tumors is challenging due to their complexity and delicate structure. Conventional imaging techniques like MRI, CT, and PET are unable to provide detailed visualization of early-stage brain tumors. Early-stage detection of brain tumors is vital for enhancing patient outcomes and survival rates. So far, several scientists have dedicated their efforts to innovating advanced diagnostic probes to efficiently cross the BBB and selectively target brain tumors for optimal imaging. The integration of these techniques presents a viable pathway for non-invasive, accurate, and early-stage tumor identification. Herein, we provide a timely update on the various imaging probes and potential challenges for the diagnosis of early-stage brain tumors. Furthermore, this review highlights the significance of integrating advanced imaging probes for improving the early detection of brain tumors, ultimately enhancing treatment outcomes. Hopefully, this review will stimulate the interest of researchers to accelerate the development of new imaging probes and even their clinical translation for improving the early diagnosis of brain tumors.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered hybrid cell membrane nanovesicles for potentiated cancer immunotherapy through dual immune checkpoint inhibition. 通过双重免疫检查点抑制增强癌症免疫治疗的工程杂交细胞膜纳米囊泡。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-09 DOI: 10.1039/d5bm00298b
Fuxu Yang, Han Xue, Yuxin Fan, Ting Zhang, Ting Wang, Fanlin Gu, Longxue Guan, Lisha Zhou, Xingang Guan, Guofu Chen
{"title":"Engineered hybrid cell membrane nanovesicles for potentiated cancer immunotherapy through dual immune checkpoint inhibition.","authors":"Fuxu Yang, Han Xue, Yuxin Fan, Ting Zhang, Ting Wang, Fanlin Gu, Longxue Guan, Lisha Zhou, Xingang Guan, Guofu Chen","doi":"10.1039/d5bm00298b","DOIUrl":"https://doi.org/10.1039/d5bm00298b","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have demonstrated remarkable success in treating various types of solid tumors; however, only a limited number of patients currently benefit from these therapeutic agents. Developing novel ICIs that elicit systemic and durable antitumor immune responses remains a significant challenge in improving immunotherapy outcomes. In this study, we engineered PD-1/LAG-3 receptors onto cell membrane nanovesicles to simultaneously block two immune checkpoints for the treatment of colorectal cancer. This dual-checkpoint blockade strategy led to significantly more potent tumor growth suppression in mice with MC38 xenografts compared to nanovesicles targeting PD-1 or LAG-3 alone. Notably, the hybrid nanovesicles substantially rejuvenated exhausted CD8<sup>+</sup> T cells, promoting dendritic cell maturation and depleting regulatory T cells (Tregs). This research highlights the promising potential of cell membrane nanovesicles as an effective platform for delivering multiple immune checkpoints in cancer immunotherapy, offering a novel strategy to enhance therapeutic efficacy.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyvinyl alcohol/casein hydrogels with oxymatrine eluting ability for cancer-related wound management. 具有氧化苦参碱洗脱能力的聚乙烯醇/酪蛋白水凝胶用于癌症相关伤口处理。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-08 DOI: 10.1039/d5bm00191a
Pedro Rainho, Madalena Salema-Oom, Carlos A Pinto, Jorge A Saraiva, Benilde Saramago, Diana C Silva, Ana Paula Serro
{"title":"Polyvinyl alcohol/casein hydrogels with oxymatrine eluting ability for cancer-related wound management.","authors":"Pedro Rainho, Madalena Salema-Oom, Carlos A Pinto, Jorge A Saraiva, Benilde Saramago, Diana C Silva, Ana Paula Serro","doi":"10.1039/d5bm00191a","DOIUrl":"https://doi.org/10.1039/d5bm00191a","url":null,"abstract":"<p><p>Malignant fungating wounds (MFWs) are cancer-related complications that arise from metastases in advanced cancers. They appear in 5-14% of cancer patients, with higher prevalence in breast (66%) and head and neck (24%) cancers. Novel therapeutic routes for the management of MFWs rely on plant-based treatments, <i>e.g.</i> oxymatrine (OXM), an alkaloid derived from a Chinese plant with anticancer and anti-inflammatory properties. The objective of this work was to assess the potential of polyvinyl alcohol/casein (PVA/CAS) hydrogels to be used as dressings for OXM delivery. CAS can stimulate the immune system, while PVA is one of the most used synthetic polymers in the composition of hydrogels for medical applications. Six different hydrogel formulations were prepared following different procedures: freeze-thawing (FT) and cast drying (CD) for 24 or 48 h, with and without the addition of genipin (GE), a crosslinking agent. The hydrogels were loaded with OXM, and their release behaviour was studied. PVA/CAS-24CD + GE showed the best release profile. After being subjected to sterilisation by high hydrostatic pressure, it was further investigated in terms of physicochemical properties, mechanical characteristics and biocompatibility. Overall, this hydrogel revealed adequate characteristics to be used as a biocompatible medicated dressing for OXM release.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteria-responsive cytoderm drug delivery systems. 细菌反应性细胞壁给药系统。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-08 DOI: 10.1039/d5bm00026b
Chenmeng Zhou, Yue Zhang, Bo Tian, Yue Yu, Dongxiao Li, Bingbing Wu, Wenju Chang, Tongguo Shi, Fang Xu, Jinyu Bai, Chao Wang
{"title":"Bacteria-responsive cytoderm drug delivery systems.","authors":"Chenmeng Zhou, Yue Zhang, Bo Tian, Yue Yu, Dongxiao Li, Bingbing Wu, Wenju Chang, Tongguo Shi, Fang Xu, Jinyu Bai, Chao Wang","doi":"10.1039/d5bm00026b","DOIUrl":"https://doi.org/10.1039/d5bm00026b","url":null,"abstract":"<p><p>Signs of bacterial activities have been reported in a variety of disease models. Here, we extracted plant cytoderm ghosts (PCGs) from plant cells, acting as bacteria-responsive drug delivery systems (DDSs) that release drugs specifically in response to the presence or activity of bacteria. Cellulose, which is one of the main components of PCGs, can be degraded in the presence of specialized bacteria that secrete enzymes to convert the cellulose into simpler sugars, thus breaking down the structure of PCGs to release the loaded drugs. In our study, PCGs loaded with ciprofloxacin (PCG@CIP) could effectively inhibit the proliferation and retention of bacteria at the infection site, and improve the local wound microenvironment to accelerate wound repair. In addition, the PCG platform with anticancer drugs could effectively regulate the progression of tumor growth. Therefore, we report a new drug delivery system that responds to the microbiota based on plant cytoderm, providing a new option for drug responsive delivery.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration. 基于生物墨水的3D打印支架的进展:优化骨再生的生物相容性和机械性能。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-07 DOI: 10.1039/d4bm01606h
Pawan Kumar, Jitender Sharma, Ravinder Kumar, Jan Najser, Jaroslav Frantik, Anju Manuja, Nagaraju Sunnam, Seepana Praveenkumar
{"title":"Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration.","authors":"Pawan Kumar, Jitender Sharma, Ravinder Kumar, Jan Najser, Jaroslav Frantik, Anju Manuja, Nagaraju Sunnam, Seepana Praveenkumar","doi":"10.1039/d4bm01606h","DOIUrl":"https://doi.org/10.1039/d4bm01606h","url":null,"abstract":"<p><p>The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for bone regeneration. This review focuses on the biocompatibility and mechanical properties essential for scaffold performance, highlighting advancements in bioink formulations, material combinations, and printing techniques. The key biomaterials, including natural polymers (gelatin, collagen, alginate), synthetic polymers (polycaprolactone, polyethylene glycol), and bioactive ceramics (hydroxyapatite, calcium phosphate), are discussed concerning their osteoconductivity, printability, and structural integrity. Despite significant progress, challenges remain in achieving optimal mechanical strength, degradation rates, and cellular interactions. The review explores emerging strategies such as gene-activated bioinks, nanocomposite reinforcements, and crosslinking techniques to enhance scaffold durability and bioactivity. By synthesizing recent developments, this work provides insights into future directions for bioink-based scaffolds, paving the way for more effective and personalized bone regenerative therapies.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
20 nm nanoparticles trigger calcium influx to endothelial cells via a TRPV4 channel. 20nm纳米颗粒通过TRPV4通道触发钙流入内皮细胞。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-07 DOI: 10.1039/d4bm01691b
Jaspreet Singh Nagi, Amber L Doiron
{"title":"20 nm nanoparticles trigger calcium influx to endothelial cells <i>via</i> a TRPV4 channel.","authors":"Jaspreet Singh Nagi, Amber L Doiron","doi":"10.1039/d4bm01691b","DOIUrl":"https://doi.org/10.1039/d4bm01691b","url":null,"abstract":"<p><p>While increased intracellular calcium (Ca<sup>2+</sup>) has been identified as a key effect of nanoparticles on endothelial cells, the mechanism has not been fully elucidated or examined under shear stress. Here, we show the effect of several types of 20 nm particles on Ca<sup>2+</sup> in the presence of shear stress in human umbilical vein endothelial cells (HUVECs), human coronary artery endothelial cells (HCAECs), and human cardiac microvascular endothelial cells (HMVEC-Cs). Intracellular Ca<sup>2+</sup> levels increased by nearly three-fold in these cell types upon exposure to 100 μg mL<sup>-1</sup> 20 nm Au particles, which was not seen in response to larger or smaller particles. An antagonist to the calcium channel - transient receptor potential vanilloid-type 4 (TRPV4) - drastically reduced the amount of calcium by 9.3-fold in HUVECs exposed to 0.6 Pa shear stress and 100 μg mL<sup>-1</sup> 20 nm gold particles, a trend upheld in both HCAECs and HMVEC-Cs. Cell alignment in the direction of fluid flow is a well-known phenomenon in endothelial cells, and interestingly, cells in the presence of 20 nm particles with fluid flow had a higher alignment index than cells in the fluid flow alone. When compared with previous works, these results indicated that 20 nm particles may be inducing endothelial permeability by activating the TRPV4 channel <i>in vitro</i>. The potential of nanoparticle delivery technologies hinges on an improved understanding of this effect toward improved delivery with limited toxicity.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A light-activated Fe2+ release nanosystem for enhanced chemodynamic/chemo therapy via cascade amplification of ROS generation. 一种光激活Fe2+释放纳米系统,通过级联扩增ROS生成来增强化学动力学/化疗。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-07 DOI: 10.1039/d4bm01425a
Wei Guo, Min Wang, Xisha Chen, Mei Wang, Yingcai Meng
{"title":"A light-activated Fe<sup>2+</sup> release nanosystem for enhanced chemodynamic/chemo therapy <i>via</i> cascade amplification of ROS generation.","authors":"Wei Guo, Min Wang, Xisha Chen, Mei Wang, Yingcai Meng","doi":"10.1039/d4bm01425a","DOIUrl":"https://doi.org/10.1039/d4bm01425a","url":null,"abstract":"<p><p>Ferrous iron (Fe<sup>2+</sup>)-based chemodynamic therapy (CDT) shows great potential for improving chemotherapeutic efficacy and reducing side effects. However, spontaneous oxidation and biological matrixes can influence the catalytic reactive oxygen species (ROS) generation of Fe<sup>2+</sup>, thereby limiting the efficacy of CDT. Herein, we reported a simple and convenient method to construct hyaluronic acid (HA)-stabilized iron/zinc oxide nanoparticles (IZ@H NPs), which showed intrinsic peroxidase (POD)-like activity and excellent light-activated Fe<sup>2+</sup> release performance. Moreover, we demonstrate that catalytic ROS generation follows a cascade amplification manner due to the light-activated release of Fe<sup>2+</sup> from IZ@H NPs, leading to formation of iron-DNA complexes (IDCs). After loading doxorubicin (DOX), the nanosystem (termed IZD@H NPs) exhibits tumor cell targeting, robust ROS generation and high cytotoxicity, significantly suppressing tumor growth in xenograft mouse models while maintaining good biosafety. This work gives novel insight into amplifying Fe<sup>2+</sup>-mediated catalytic ROS generation and presents a new strategy for <i>in vivo</i> Fe<sup>2+</sup> delivery to enhance chemodynamic/chemotherapy.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Micro/nanomotors for active inflammatory disease therapy. 用于主动炎性疾病治疗的微/纳米马达。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-04 DOI: 10.1039/d5bm00052a
Xue Yang, Lishan Zhang, Hui Ran, Fei Peng, Yingfeng Tu
{"title":"Micro/nanomotors for active inflammatory disease therapy.","authors":"Xue Yang, Lishan Zhang, Hui Ran, Fei Peng, Yingfeng Tu","doi":"10.1039/d5bm00052a","DOIUrl":"https://doi.org/10.1039/d5bm00052a","url":null,"abstract":"<p><p>Inflammation is a carefully orchestrated response of the immune system to repair injured tissues and clear various damage factors. However, dysregulated inflammation can eventually contribute to the development and progression of various inflammatory diseases. Although anti-inflammatory drugs have demonstrated certain therapeutic efficacy in clinical settings, significant limitations still persist, highlighting the necessity for the development of improved approaches to address complex inflammatory conditions. Micro/nanomotors (MNMs) have shown significant promise for applications in the biomedical field due to their micro/nano-scale sizes and autonomous movement. Unlike traditional nanoparticles, which exhibit passive diffusion in biological fluids, MNMs can convert external energy into a driving force for self-propulsion. This capability not only enhances the tissue penetration depth and retention rates but also facilitates interaction with inflammatory lesions. Recent efforts have suggested that MNMs for inflammatory disease therapy could provide an efficient therapeutic effect. Herein, we mainly introduce the recent advances in inflammatory disease therapy based on MNMs. We conclude by discussing both the obstacles and potential opportunities for MNMs innovations in addressing inflammation.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OBOC screening of high activity and low-toxic polymyxin analogs against MCR-1 resistant strains. OBOC筛选抗MCR-1耐药菌株的高活性低毒多粘菌素类似物。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-04-03 DOI: 10.1039/d5bm00362h
Wenhong Zheng, Xin Wang, Hao Lian, Pengfei Zou, Tongyi Sun, Hao Wang, Li-Li Li
{"title":"OBOC screening of high activity and low-toxic polymyxin analogs against MCR-1 resistant strains.","authors":"Wenhong Zheng, Xin Wang, Hao Lian, Pengfei Zou, Tongyi Sun, Hao Wang, Li-Li Li","doi":"10.1039/d5bm00362h","DOIUrl":"https://doi.org/10.1039/d5bm00362h","url":null,"abstract":"<p><p>We performed inverse synthesis to create 1152 structural analogs of polymyxin B with modified hydrophilicity and charge properties using OBOC technology. This led to the identification of two promising candidates that provided insights into structure-activity relationships. These compounds maintained high antibacterial activity while expanding the safety window 4-16 times.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信