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The semi-interpenetrating network hydrogel loaded with Oridonin and DNase-I on healing of chemoradiotherapy-induced oral mucositis 负载奥利多宁和 DNase-I 的半穿透性网络水凝胶对化疗引起的口腔黏膜炎愈合的影响
IF 6.6 3区 医学
Biomaterials Science Pub Date : 2024-07-11 DOI: 10.1039/d4bm00114a
Yuxue Pan, Mengyuan Wang, Peng Wang, Hongliang Wei, Xiangjuan Wei, Dongmei Wang, Yongwei Hao, Yongxue Wang, Hongli Chen
{"title":"The semi-interpenetrating network hydrogel loaded with Oridonin and DNase-I on healing of chemoradiotherapy-induced oral mucositis","authors":"Yuxue Pan, Mengyuan Wang, Peng Wang, Hongliang Wei, Xiangjuan Wei, Dongmei Wang, Yongwei Hao, Yongxue Wang, Hongli Chen","doi":"10.1039/d4bm00114a","DOIUrl":"https://doi.org/10.1039/d4bm00114a","url":null,"abstract":"Oral mucositis (OM) is a common side effect experienced by cancer patients undergoing chemotherapy and/or radiotherapy. In this study, we developed a semi-interpenetrating network hydrogel (IPN) that is suitable for adhesion to oral mucous membranes and gradual degradation in the oral environment. This IPN was based on the combination of ε-polylysine (PLL) and Hetastarch (HES), loaded with DNase-I and Oridonin (ORI) (ORI/DNase-I/IPN) for the treatment of OM. In vitro studies were conducted to evaluate degradation, adhesion, release analysis, as well as bioactivity including cell proliferation and wound healing assays using epidermal keratinocyte and fibroblast cell lines. Furthermore, the therapeutic effects of ORI/DNase-I/IPN were investigated in vivo using Sprague-Dawley (SD) rats with chemoradiotherapy-induced OM. The results demonstrated that the IPN exhibited excellent adhesion to wet mucous membranes, and the two drugs co-encapsulated in the hydrogel were released in a controlled manner. The in vivo wound repair effect, microbiological assays, H&E and Masson staining supported the non-toxicity of ORI/DNase-I/IPN, as well as its ability to accelerate the healing of oral ulcers and reduce inflammation. Overall, ORI/DNase-I/IPN demonstrated a therapeutic effect on oral ulcers in rats by significantly accelerating the healing process and reducing inflammation. These findings provide new insights into possible therapies for OM.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141584705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasmall Magnolol/Ebselen Nanomicelles for Preventing Renal Ischemia/Reperfusion Injury 用于预防肾缺血/再灌注损伤的超小型木兰醇/易倍申纳米细胞
IF 6.6 3区 医学
Biomaterials Science Pub Date : 2024-07-11 DOI: 10.1039/d4bm00614c
Chang Liu, Linhua Li, Li Li, Qingyin Li, Jing Liu, Chunle Zhang, Zhengjiang Cao, Liang Ma, Xiaoxi Zeng, Ping Fu
{"title":"Ultrasmall Magnolol/Ebselen Nanomicelles for Preventing Renal Ischemia/Reperfusion Injury","authors":"Chang Liu, Linhua Li, Li Li, Qingyin Li, Jing Liu, Chunle Zhang, Zhengjiang Cao, Liang Ma, Xiaoxi Zeng, Ping Fu","doi":"10.1039/d4bm00614c","DOIUrl":"https://doi.org/10.1039/d4bm00614c","url":null,"abstract":"Renal ischemia/reperfusion injury (RIRI) is an inevitable complication following kidney transplantation surgery, accompanied by the generation of massive of free radicals. The cascade of events including oxidative stress, extreme inflammation, cellular apoptosis, thrombosis disrupts the microenvironment of renal cells and the hematological system, ultimately leading to the development of acute kidney injury/ failure. Current research primarily focuses on reducing inflammation and mitigating damage to renal cells through antioxidative approaches. However, studies on simultaneously modulating the renal hematologic system remain unreported. Herein, a potent and novel drug-loaded nanomicelles can be efficiently self-assembled with magnolol (MG) and ebselen (EBS) by the π-π conjugation, hydrophobic action and the surfactant properties of Tween-80. The ultrasmall MG/EBS nanomicelles (Average particle size: 10–25 nm) not only fully preserve the activity of both drugs but also greatly enhance drug utilization (encapsulation rates: MG-90.1%, EBS-49.3%) and reduce drug toxicity. Furthermore, EBS, as a glutathione peroxidase mimic and NO catalyst, synergistically collaborates with the multifunctional MG to scavenge free radicals, significantly inhibiting inflammation and thrombosis while effectively preventing apoptosis of vascular endothelial cells and renal tubular epithelial cells. This study provides a new strategy and theoretical foundation for the simultaneous regulation of kidney cells and blood microenvironment stability.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141584733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel bi-layered asymmetric membrane incorporating demineralized dentin matrix accelerates tissue healing and bone regeneration in a rat skull defect model. 在大鼠颅骨缺损模型中,含有脱矿质牙本质基质的新型双层不对称膜可加速组织愈合和骨再生。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2024-07-10 DOI: 10.1039/d4bm00350k
Yan-Fei Li, Qi-Pei Luo, Yu-Xin Yang, An-Qi Li, Xin-Chun Zhang
{"title":"A novel bi-layered asymmetric membrane incorporating demineralized dentin matrix accelerates tissue healing and bone regeneration in a rat skull defect model.","authors":"Yan-Fei Li, Qi-Pei Luo, Yu-Xin Yang, An-Qi Li, Xin-Chun Zhang","doi":"10.1039/d4bm00350k","DOIUrl":"https://doi.org/10.1039/d4bm00350k","url":null,"abstract":"<p><p><i>Objectives</i>: The technique of guided bone regeneration (GBR) has been widely used in the field of reconstructive dentistry to address hard tissue deficiency. The objective of this research was to manufacture a novel bi-layered asymmetric membrane that incorporates demineralized dentin matrix (DDM), a bioactive bone replacement derived from dentin, in order to achieve both soft tissue isolation and hard tissue regeneration simultaneously. <i>Methods</i>: DDM particles were harvested from healthy, caries-free permanent teeth. The electrospinning technique was utilized to synthesize bi-layered DDM-loaded PLGA/PLA (DPP) membranes. We analyzed the DPP bilayer membranes' surface topography, physicochemical properties and degradation ability. Rat skull critical size defects (CSDs) were constructed to investigate <i>in vivo</i> bone regeneration. <i>Results</i>: The synthesized DPP bilayer membranes possessed suitable surface characteristics, acceptable mechanical properties, good hydrophilicity, favorable apatite forming ability and suitable degradability. Micro-computed tomography (CT) showed significantly more new bone formation in the rat skull defects implanted with the DPP bilayer membranes. Histological evaluation further revealed that the bone was more mature with denser bone trabeculae. In addition, the DPP bilayer membrane significantly promoted the expression of the OCN matrix protein <i>in vivo</i>. <i>Conclusions</i>: The DPP bilayer membranes exhibited remarkable biological safety and osteogenic activity <i>in vivo</i> and showed potential as a prospective candidate for GBR applications in the future.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitosan-based Hydrogel Loaded with Fenofibrate for Diabetic Wound Healing 添加非诺贝特的壳聚糖水凝胶用于糖尿病伤口愈合
IF 6.6 3区 医学
Biomaterials Science Pub Date : 2024-07-10 DOI: 10.1039/d4bm00499j
Miaofeng Wang, Yaping Deng, Cancan Huang, Ansar Javeed, Yifan Wang, Bingnan Han, Guojun Jiang
{"title":"Chitosan-based Hydrogel Loaded with Fenofibrate for Diabetic Wound Healing","authors":"Miaofeng Wang, Yaping Deng, Cancan Huang, Ansar Javeed, Yifan Wang, Bingnan Han, Guojun Jiang","doi":"10.1039/d4bm00499j","DOIUrl":"https://doi.org/10.1039/d4bm00499j","url":null,"abstract":"Diabetic wounds represent a common chronic condition, posing significant challenges in the treatment process due to bacterial infections, increased generation of reactive oxygen species (ROS) and exacerbated inflammation. Fenofibrate (FEN) is a clinical medication used for lipid regulation. In this study, it was utilized for the first time as an effective component in wound dressings for treating diabetic ulcers, exploring its novel applications further. Therefore, we prepared a polyvinyl alcohol/chitosan/FEN (PCF) hydrogel using a freeze-thaw method and conducted physicochemical characterization of the PCF hydrogel to further elucidate its biological functions. In vitro studies demonstrated that the PCF hydrogel exhibits excellent biocompatibility along with significant antimicrobial, pro-angiogenic, ROS-scavenging, and anti-inflammatory properties. Subsequent animal experiments indicated that PCF hydrogel has the ability to promote blood vessel formation and collagen deposition. Additionally, PCF hydrogel showed a significant inhibitory effect on the inflammatory response, as evidenced by reductions in levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). These compelling findings accentuate the promising application of PCF hydrogel in the treatment of diabetic wounds.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141575197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thiolated polyglycerol sulfate as potential mucolytic for muco-obstructive lung diseases 硫醇化聚甘油硫酸盐作为潜在的粘液溶解剂,可治疗粘液阻塞性肺病
IF 6.6 3区 医学
Biomaterials Science Pub Date : 2024-07-10 DOI: 10.1039/d4bm00381k
Justin Arenhoevel, Aditi Kuppe, Annalisa Addante, Nico Boback, Ling-Fang Wei, Cosmin S. Butnarasu, Yinan Zhong, Christine Wong, Simon Y. Graeber, Julia Gräber-Dürr, Michael Gradzielski, Daniel Lauster, Marcus A. Mall, Rainer Haag
{"title":"Thiolated polyglycerol sulfate as potential mucolytic for muco-obstructive lung diseases","authors":"Justin Arenhoevel, Aditi Kuppe, Annalisa Addante, Nico Boback, Ling-Fang Wei, Cosmin S. Butnarasu, Yinan Zhong, Christine Wong, Simon Y. Graeber, Julia Gräber-Dürr, Michael Gradzielski, Daniel Lauster, Marcus A. Mall, Rainer Haag","doi":"10.1039/d4bm00381k","DOIUrl":"https://doi.org/10.1039/d4bm00381k","url":null,"abstract":"Increased disulfide crosslinking of secreted mucins causes elevated viscoelasticity of mucus and is a key determinant of mucus dysfunction in patients with cystic fibrosis (CF) and other muco-obstructive lung diseases. In this study, we describe the synthesis of a novel thiol-containing, sulfated dendritic polyglycerol (dPGS-SH), designed to chemically reduce these abnormal crosslinks, which we demonstrate with mucolytic activity assays in sputum from patients with CF. This mucolytic polymer, which is based on a reportedly anti-inflammatory polysulfate scaffold, additionally carries multiple thiol groups for mucolytic activity and can be produced on a gram-scale. After a physicochemical compound characterization, we compare the mucolytic activity of dPGS-SH to the clinically approved N-acetylcysteine (NAC) using Western blot studies and investigate the effect of dPGS-SH on the viscoelastic properties of sputum samples from CF patients by oscillatory rheology. We show that dPGS-SH is more effective than NAC in reducing multimer intensity of the secreted mucins MUC5B and MUC5AC and demonstrate significant mucolytic activity by rheology. In addition, we provide data for dPGS-SH demonstrating a high compound stability, low cytotoxicity, and superior reaction kinetics over NAC at different pH levels. Our data support further development of the novel reducing polymer system dPGS-SH as a potential mucolytic to improve mucus function and clearance in patients with CF as well as other muco-obstructive lung diseases.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141575196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning Molecular Assembly Behavior to Amplify Sonodynamic Activity of Porphyrin for Efficient Antibacterial Therapy 调整分子组装行为,增强卟啉的声动力活性,实现高效抗菌疗法
IF 6.6 3区 医学
Biomaterials Science Pub Date : 2024-07-10 DOI: 10.1039/d4bm00706a
Yunxia Wang, Yicheng Xu, Rui Zhang, Jing Li, Yujie Cong, Ruipeng Li, Xiaoyu Wang, Hu Shi, Shaowei Wang, Liheng Feng
{"title":"Tuning Molecular Assembly Behavior to Amplify Sonodynamic Activity of Porphyrin for Efficient Antibacterial Therapy","authors":"Yunxia Wang, Yicheng Xu, Rui Zhang, Jing Li, Yujie Cong, Ruipeng Li, Xiaoyu Wang, Hu Shi, Shaowei Wang, Liheng Feng","doi":"10.1039/d4bm00706a","DOIUrl":"https://doi.org/10.1039/d4bm00706a","url":null,"abstract":"Sonodynamic therapy (SDT) is of promising strategy to treat deep-seated bacterial infection with good tissue penetration and spatiotemporal controllability. However, the low ROS generation efficiency of current sonosensitizers limits the development of SDT. Herein, we report a porphyrin derivative (TAPyPP-2) by tuning molecular assembly behavior to enhance sonodynamic activity with less oxygen dependence. TAPyPP-2 can spontaneously form ultra-small nano-assembly with diameter of 6 nm in water by conjugation of a primary amine salts-decorated pyridinium via - staking. The ultra-small assembly behavior can lower the energy gap between singlet and triplet states to 0.01 eV and promote the separation of holes and electrons, which facilitates ROS generation under ultrasound irradiation, especially type I ROS. Unique hydrophilic ratio and positive charges endow TAPyPP-2 superior interactions with Staphylococcus aureus, resulting in extremely high sonodynamic antibacterial activity. Therefore, TAPyPP-2 successfully kills the Staphylococcus aureus in enclosed cavity of synovial joint and achieves the effective SDT of septic arthritis. This work is anticipated to motivate enormous interest in the development of efficient SDT.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of Nanotechnology in Remodeling Tumour Microenvironment for Glioblastoma Treatment 纳米技术在重塑肿瘤微环境治疗胶质母细胞瘤中的应用
IF 6.6 3区 医学
Biomaterials Science Pub Date : 2024-07-09 DOI: 10.1039/d4bm00665h
Yulei Mu, Zhen Zhang, Huiqun Zhou, Liang Ma, Dong-An Wang
{"title":"Applications of Nanotechnology in Remodeling Tumour Microenvironment for Glioblastoma Treatment","authors":"Yulei Mu, Zhen Zhang, Huiqun Zhou, Liang Ma, Dong-An Wang","doi":"10.1039/d4bm00665h","DOIUrl":"https://doi.org/10.1039/d4bm00665h","url":null,"abstract":"With the increasing research and deepening understanding of the glioblastoma (GBM) tumour microenvironment (TME), novel and more effective therapeutic strategies have been proposed. The GBM TME involves intricate interactions between tumour and non-tumour cells, promoting tumour progression. Key therapeutic goals for GBM treatment include improving the immunosuppressive microenvironment, enhancing the cytotoxicity of immune cells against tumours, and inhibiting tumour growth and proliferation. Consequently, remodeling the GBM TME using nanotechnology has emerged as a promising approach. Nanoparticle-based drug delivery enables targeted delivery, thereby improving treatment specificity, facilitating combination therapies, and optimizing drug metabolism. This review provides an overview of the GBM TME and discusses the methods of remodeling the GBM TME using nanotechnology. Specifically, it explores the application of nanotechnology in ameliorating immune cell immunosuppression, inducing immunogenic cell death, stimulating, and recruiting immune cells, regulating tumour metabolism, and modulating the crosstalk between tumours and other cells.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141575198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delivery of rapamycin by biomimetic peptide nanoparticles targeting oxidized low-density lipoprotein in atherosclerotic plaques. 以动脉粥样硬化斑块中的氧化低密度脂蛋白为靶点的生物仿肽纳米粒子输送雷帕霉素。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2024-07-09 DOI: 10.1039/d4bm00367e
Anqi Wang, Kai Yue, Weishen Zhong, Genpei Zhang, Lei Wang, Hua Zhang, Xinxin Zhang
{"title":"Delivery of rapamycin by biomimetic peptide nanoparticles targeting oxidized low-density lipoprotein in atherosclerotic plaques.","authors":"Anqi Wang, Kai Yue, Weishen Zhong, Genpei Zhang, Lei Wang, Hua Zhang, Xinxin Zhang","doi":"10.1039/d4bm00367e","DOIUrl":"https://doi.org/10.1039/d4bm00367e","url":null,"abstract":"<p><p>Drug delivery systems based on biomimetic peptide nanoparticles are steadily gaining prominence in the treatment of diverse medical conditions. This study focused on the development of peptides that depend on ligand-receptor interactions to load rapamycin (RAPA). Furthermore, a multifunctional peptide was engineered to target oxidized low-density lipoprotein (oxLDL) within atherosclerotic plaques, facilitating the localized delivery of RAPA. The interactions between peptides and RAPA/oxLDL were analyzed by simulations and experimental approaches. Results show that the main amino acid residues on the mammalian target of rapamycin that bind to RAPA are constructed as peptides (P1 and P2), which have specific interactions with RAPA and can effectively improve the loading efficiency of RAPA. The encapsulation and drug loading efficiencies of P1/P2 were 68.0/47.9% and 48.3/36.5%, respectively. In addition, the interaction force of the multifunctional peptide (P3) and oxLDL surpassed that of their interaction with human umbilical vein endothelial cells by a factor of 3.6, conclusively establishing the specific targeting of oxLDL by these nanoparticles. The encapsulation and drug loading efficiencies of P3 for RAPA were determined to be 60.2% and 41.5%. P3 can effectively load RAPA and target oxLDL within the plaque, suggesting that P3 has potential as a therapeutic agent for atherosclerotic disease.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141557469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric and visualization analysis of the application of inorganic nanomaterials to autoimmune diseases. 无机纳米材料应用于自身免疫性疾病的文献计量和可视化分析。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2024-07-09 DOI: 10.1039/d3bm02015k
Baiyan Zhang, Yuanyuan Guo, Yu Lu, Dan Ma, Xiahui Wang, Liyun Zhang
{"title":"Bibliometric and visualization analysis of the application of inorganic nanomaterials to autoimmune diseases.","authors":"Baiyan Zhang, Yuanyuan Guo, Yu Lu, Dan Ma, Xiahui Wang, Liyun Zhang","doi":"10.1039/d3bm02015k","DOIUrl":"https://doi.org/10.1039/d3bm02015k","url":null,"abstract":"<p><p><i>Objective</i>: To conduct bibliometric analysis of the application of inorganic nanomaterials to autoimmune diseases to characterize current research trends and to visualize past and emerging trends in this field in the past 15 years. <i>Methods</i>: The evolution and thematic trends of the application of inorganic nanomaterials to autoimmune diseases from January 1, 1985, to March 15, 2024, were analyzed by bibliometric analysis of data retrieved and extracted from the Web of Science Core Collection (WoSCC) database. A total of 734 relevant reports in the literature were evaluated according to specific characteristics such as year of publication, journal, institution, country/region, references, and keywords. VOSviewer was used to build co-authorship analysis, co-occurrence analysis, co-citation analysis, and network visualization. Some important subtopics identified by bibliometric characterization are further discussed and reviewed. <i>Result</i>: From 2009 to 2024, annual publications worldwide increased from 11 to 95, an increase of 764%. <i>ACS Nano</i> published the most papers (14) with the most citations (1372). China (230 papers, 4922 citations) and the Chinese Academy of Sciences (36 papers, 718 citations) are the most productive and influential country and institution, respectively. The first 100 keywords were co-clustered to form four clusters: (1) the application of inorganic nanomaterials in drug delivery, (2) the application of inorganic nano-biosensing to autoimmune diseases, (3) the use of inorganic nanomaterials for imaging applied to autoimmune diseases, and (4) the application of inorganic nanomaterials in the treatment of autoimmune diseases. Combination therapy, microvesicles, photothermal therapy (PTT), targeting, diagnostics, transdermal, microneedling, silver nanoparticles, psoriasis, and inflammatory cytokines are the latest high-frequency keywords, marking the emerging frontier of inorganic nanomaterials in the field of autoimmune diseases. Sub-topics were further discussed to help researchers determine the scope of research topics and plan research directions. <i>Conclusion</i>: Over the past 39 years, the application of inorganic nanotechnology to the field of autoimmune diseases shows extensive cooperation between countries and institutions, showing a continuous increase in the number of reports in the literature, and has clinical translation prospects. Future research should further improve the safety of inorganic nanomaterials, clarify the mechanism of action of nanomaterials, establish a standardized nanomaterial preparation and performance evaluation system, and ultimately achieve the goal of early detection and precise treatment of autoimmune diseases.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141557468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melatonin-loaded mesoporous zinc- and gallium-doped hydroxyapatite nanoparticles to control infection and bone repair. 褪黑素介孔锌和掺镓羟基磷灰石纳米颗粒用于控制感染和骨修复。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2024-07-09 DOI: 10.1039/d4bm00377b
Mahshid Shokri, Mahshid Kharaziha, Hossein Ahmadi Tafti, Faezeh Dalili, Rouhollah Mehdinavaz Aghdam, Seyed Reza Ghiassi, Mohamadreza Baghaban Eslaminejad
{"title":"Melatonin-loaded mesoporous zinc- and gallium-doped hydroxyapatite nanoparticles to control infection and bone repair.","authors":"Mahshid Shokri, Mahshid Kharaziha, Hossein Ahmadi Tafti, Faezeh Dalili, Rouhollah Mehdinavaz Aghdam, Seyed Reza Ghiassi, Mohamadreza Baghaban Eslaminejad","doi":"10.1039/d4bm00377b","DOIUrl":"https://doi.org/10.1039/d4bm00377b","url":null,"abstract":"<p><p>Effective treatment of infected bone defects resulting from multi-drug resistant bacteria (MDR) has emerged as a significant clinical challenge, highlighting the pressing demand for potent antibacterial bone graft substitutes. Mesoporous nanoparticles have been introduced as a promising class of biomaterials offering significant properties for treating bone infections. Herein, we synthesize antibacterial mesoporous hydroxyapatite substituted with zinc and gallium (Zn-Ga:mHA) nanoparticles using a facile sol-gel method. The resulting mesoporous nanoparticles are applied for the controlled release of melatonin (Mel). Zn-Ga:mHA nanoparticles with an average particle size of 36 ± 3 nm and pore size of 10.6 ± 0.4 nm reveal a Mel loading efficiency of 58 ± 1%. Results show that 50% of Mel is released within 20 h and its long-term release is recorded up to 50 h. The Zn-Ga:mHA nanoparticles exhibit highly effective antibacterial performance as reflected by a 19 ± 1% and 8 ± 2% viability reduction in <i>Escherichia coli</i> and <i>Staphylococcus</i> bacteria, respectively. Noticeably, Mel-loaded Zn-Ga:mHA nanoparticles are also cytocompatible and stimulate <i>in vitro</i> osteogenic differentiation of human mesenchymal stem cells (hMSCs) without any osteoinductive factor. <i>In vivo</i> studies in a rabbit skull also show significant regeneration of bone during 14 days. In summary, Mel-loaded Zn-Ga:mHA nanoparticles provide great potential as an antibacterial and osteogenic component in bone substitutes like hydrogels, scaffolds, and coatings.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141557470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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