Biomaterials Science最新文献

Engineering a bacterial polysaccharide-based metal-organic framework-enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing. 设计一种基于细菌多糖的金属有机框架增强生物活性3D水凝胶，用于加速全层伤口愈合。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-28 DOI: 10.1039/d5bm00133a

Aniruddha Dan, Ankita Panigrahi, Hemant Singh, Varsha Murali, Manisha Meena, Prateek Goyel, Laxmanan Karthikeyan, Superb K Misra, Nibu Varghese, Sharlene Sara Babu, Yogesh B Dalvi, Mukesh Dhanka

{"title":"Engineering a bacterial polysaccharide-based metal-organic framework-enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing.","authors":"Aniruddha Dan, Ankita Panigrahi, Hemant Singh, Varsha Murali, Manisha Meena, Prateek Goyel, Laxmanan Karthikeyan, Superb K Misra, Nibu Varghese, Sharlene Sara Babu, Yogesh B Dalvi, Mukesh Dhanka","doi":"10.1039/d5bm00133a","DOIUrl":"https://doi.org/10.1039/d5bm00133a","url":null,"abstract":"Hydrogels offer numerous advantages in wound healing, making them a promising alternative to traditional wound dressings. Their biocompatibility and high water content closely resemble natural biological tissues, creating a moist environment that accelerates cell proliferation and tissue repair. Hydrogels maintain optimal hydration levels, preventing wound desiccation and promoting faster healing. Furthermore, their ability to incorporate and deliver therapeutic agents such as antibiotics, anti-inflammatory drugs, or growth factors provides a multifunctional platform for enhanced wound care. Despite these advantages, current clinical wound-dressing materials often fall short in addressing the complexities of wound healing. Hydrogels, with their customizable properties and potential for integration with emerging technologies, represent a significant opportunity to overcome these limitations and improve clinical outcomes in wound management. Herein, we developed a multi-functional Cu-MOF and tannic acid-enriched polymeric hydrogel dressing composed of gellan-gum/zein for full-thickness wound repair. The physical interactions, including electrostatic interaction and hydrogen bonding between the hydrogel components, form a stable hydrogel matrix. The hydrogel exhibits antioxidant properties and antibacterial activity, and is hemocompatible and biocompatible against L929 fibroblast cells. Furthermore, the fabricated hydrogel dressing improvised a full-thickness wound-healing process in rats. Only 1.6% of the wound area was remaining in the case of GG-Z-TA/M1-treated full-thickness wounds in rats. Histopathology images suggest the Cu-MOF-loaded hydrogels aided in extensive re-epithelialization, neovascularization, and hair follicle formation to accelerate the wound-healing process.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma protein corona on silica nanoparticles enhances exocytosis. 二氧化硅纳米颗粒上的血浆蛋白电晕增强胞吐作用。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-28 DOI: 10.1039/d4bm01189a

Laura Dietz, Julia Simon, Kai R Speth, Katharina Landfester, Volker Mailänder

{"title":"Plasma protein corona on silica nanoparticles enhances exocytosis.","authors":"Laura Dietz, Julia Simon, Kai R Speth, Katharina Landfester, Volker Mailänder","doi":"10.1039/d4bm01189a","DOIUrl":"https://doi.org/10.1039/d4bm01189a","url":null,"abstract":"While the influence of the protein corona on nanoparticle uptake in mammalian cells is well understood, little is known about the influence of the protein corona on nanoparticle exocytosis. However, the exocytosis of nanoparticles also contributes to the therapeutic efficacy as it influences the net delivery of nanoparticles to a cell. In this study we demonstrate that the exocytosis of silica nanoparticles from HCT 116 cells is enhanced by the pre-adsorption of a human plasma protein corona. This pre-adsorption effect also depends on the diameter of the nanoparticles. The exocytosis of small silica nanoparticles (10 nm) is less pronounced, while the exocytosis of larger silica nanoparticles (100 nm) is significantly increased in the presence of a protein corona. A proteomic analysis of the plasma protein corona of the different-sized silica nanoparticles (10 nm, 30 nm, 50 nm, and 100 nm) reveals different protein compositions. Apolipoproteins and coagulation proteins are enriched in a size-dependent manner with high amounts of apolipoproteins adsorbed to small silica nanoparticles. The findings underscore the significance of the nanoparticle protein corona for exocytosis and demonstrate the need to engineer nanocarriers that are not exocytosed rapidly to enhance the efficacy in drug delivery.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Borax - and tannic acid-based post-3D-printing treatment to tune the mechanical properties of scaffolds. 以硼砂和单宁酸为基础的3d打印后处理，以调整支架的机械性能。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-28 DOI: 10.1039/d5bm00151j

Julia Simińska-Stanny, Parinaz Hobbi, Pejman Ghaffari-Bohlouli, Man Li, Adam Junka, Hafez Jafari, Christine Delporte, Lei Nie, Armin Shavandi

{"title":"Borax - and tannic acid-based post-3D-printing treatment to tune the mechanical properties of scaffolds.","authors":"Julia Simińska-Stanny, Parinaz Hobbi, Pejman Ghaffari-Bohlouli, Man Li, Adam Junka, Hafez Jafari, Christine Delporte, Lei Nie, Armin Shavandi","doi":"10.1039/d5bm00151j","DOIUrl":"https://doi.org/10.1039/d5bm00151j","url":null,"abstract":"Digital light processing (DLP) methods are constrained by the narrow range of cell-compatible resins, limiting their use in biomedical applications that require varied mechanical and biofunctional properties. Current bioresins based on natural polymers such as methacrylated gelatine or alginate usually lack sufficient stretchability and toughness. In this study, we propose a post-processing strategy to tune the mechanical and functional properties of a DLP printable polyethylene glycol diacrylate (PEGDA)/polyvinyl alcohol (PVA) resin via simple treatment with 5% (w/v) tannic acid (TA) or borax (B). The TA treatment reduced the resin's toughness by ∼17% and compressive modulus by ∼16%, while B treatment increased the toughness by ∼53% and the compressive modulus by ∼44% compared with non-treated hydrogels. TA-treated hydrogels continuously released over 59% of the loaded TA, demonstrating antibacterial and radical scavenging activities. Moreover, TA-treated hydrogels, DLP-printed in a tubular shape, demonstrated the highest durability, remaining intact for ∼32 cycles before failure, which was ∼17 cycles more than that for the non-treated hydrogels. Our in vivo larval model further confirmed the hydrogels' biocompatibility. This study offers a practical approach for post-fabrication tuning of the mechanical and bioactive properties of DLP-printed PEGDA-PVA hydrogels, expanding the utility of existing resins for potential biomedical applications, such as soft tissue engineering.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A core-shell structured biphasic microneedle system as an elite squad for combating melanoma with "three-in-one" therapeutic power. 核-壳结构双相微针系统是对抗黑色素瘤的精锐团队，具有“三合一”的治疗能力。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-27 DOI: 10.1039/d5bm00371g

Qiling Jin, Ying Wang, Wenwen Lei, Shuyao Zhou, Tingting Zhang, Keqiang Lu, Lingzhi Zhao, Wenying Zhong, Keming Xu

{"title":"A core-shell structured biphasic microneedle system as an elite squad for combating melanoma with \"three-in-one\" therapeutic power.","authors":"Qiling Jin, Ying Wang, Wenwen Lei, Shuyao Zhou, Tingting Zhang, Keqiang Lu, Lingzhi Zhao, Wenying Zhong, Keming Xu","doi":"10.1039/d5bm00371g","DOIUrl":"https://doi.org/10.1039/d5bm00371g","url":null,"abstract":"Achieving optimal therapeutic outcomes with microneedle (MN) technology requires a high drug payload, tunable mechanical strength, and robust drug stability-key attributes in demand for transdermal drug delivery. This work introduces a core-shell structured biphasic MN system designed to combat melanoma with \"three-in-one\" therapeutic power. The MN base, made of water-insoluble poly(methyl methacrylate), forms a biphasic interface with the needle body. Acting as a \"shield\", the base effectively prevents drug migration and enhances the drug-loading capacity of the needle body. The needle body features a core-shell design, with a shell composed of photo-cross-linked hydrogel. This shell serves as a \"spear\" to optimize mechanical properties of MNs, efficiently piercing the skin barrier. Meanwhile, the core section of MN, constructed from hyaluronic acid, acts as a \"bow and arrow\" to preserve the bioactivity of chlorin e6 nanoparticles for launching an effective \"attack\" on melanoma cells through photodynamic therapy. The MN system demonstrates exceptional mechanical performance and enhanced anticancer efficacy against melanoma cells both in vitro and in vivo. In summary, this study introduces a new \"elite squad\" strategy that integrates three critical functionalities into a single MN platform, offering significant potential for treating melanoma and other malignant skin conditions.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study of saponin-encapsulated ultrasound microbubbles Rb₃NPs@MBs for atherosclerosis targeted treatment. 皂素包封超声微泡Rb3NPs@MBs用于动脉粥样硬化靶向治疗的研究。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-27 DOI: 10.1039/d5bm00078e

Chunting Zhong, Jianhua Bai, Xiaoting Yang, Yiran Ji, Jiabao Huang, Xiao Tan, Xiaoyu Chen, LiJun Xing, Bingxuan Xu, Dianhuan Tan, Yun Chen, Tingting Zheng

{"title":"A study of saponin-encapsulated ultrasound microbubbles Rb3NPs@MBs for atherosclerosis targeted treatment.","authors":"Chunting Zhong, Jianhua Bai, Xiaoting Yang, Yiran Ji, Jiabao Huang, Xiao Tan, Xiaoyu Chen, LiJun Xing, Bingxuan Xu, Dianhuan Tan, Yun Chen, Tingting Zheng","doi":"10.1039/d5bm00078e","DOIUrl":"https://doi.org/10.1039/d5bm00078e","url":null,"abstract":"Atherosclerosis remains a leading disease posing significant threats to human health and life. Oxidative stress plays a critical role in the initiation of early atherosclerosis. Ginsenoside Rb3 has been shown to exert potential therapeutic effects against atherosclerosis due to its antioxidant properties. However, its clinical utility remains constrained to the nanometer scale, offering insufficient targeting capability for atherosclerosis treatment. To address this limitation, we designed a novel Rb3-loaded microbubble system Rb3NPs@MBs. This microbubble system effectively encapsulates Rb3 nanoparticles and, via ultrasound-targeted microbubble destruction (UTMD), facilitates their targeted accumulation in the aortic arch of atherosclerotic mice. Subsequently, Rb3NPs@MBs reduce oxidative stress, attenuate endothelial cell apoptosis and foam cell formation, and ultimately diminish plaque development at the lesion site. This strategy holds promise as a therapeutic approach for atherosclerosis. These findings suggest that Rb3NPs@MBs represent a promising therapeutic strategy for atherosclerosis.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming the novel glycan-lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy. 克服肿瘤微环境中新的聚糖-凝集素检查点，实现基于交叉呈递的免疫治疗的成功。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-27 DOI: 10.1039/d4bm01732c

Mannat Jain, Isha M Jadhav, Suyash Vinayak Dangat, Srinivasa Rao Singuru, Gautam Sethi, Eiji Yuba, Rajesh Kumar Gupta

{"title":"Overcoming the novel glycan-lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy.","authors":"Mannat Jain, Isha M Jadhav, Suyash Vinayak Dangat, Srinivasa Rao Singuru, Gautam Sethi, Eiji Yuba, Rajesh Kumar Gupta","doi":"10.1039/d4bm01732c","DOIUrl":"https://doi.org/10.1039/d4bm01732c","url":null,"abstract":"In pursuit of meeting the ever-rising demand for cancer therapies, cross-presentation-based glyconanovaccines (GNVs) targeting C-type lectin receptors (CLRs) on DCs have shown significant potential as cutting-edge cancer immunotherapy. GNVs are an attractive approach to induce anti-cancer cytotoxic T lymphocyte responses. Despite immune checkpoints (ICs) being well established and an obstacle to the success of GNVs, glycan-lectin circuits are emerging as unique checkpoints due to their immunomodulatory functions. Given the role of aberrant tumor glycosylation in promoting immune evasion, mitigating these effects is crucial for the efficacy of GNVs. Lectins, such as siglecs and galectins, are detrimental to the tumor immune landscape as they promote an immunosuppressive TME. From this perspective, this review aims to explore glycan-lectin ICs and their influence on the efficacy of GNVs. We aim to discuss various ICs in the TME followed by drawbacks of immune checkpoint inhibitors (ICIs). We will also emphasize the altered glycosylation profile of tumors, addressing their immunosuppressive nature along with ways in which CLRs, siglecs, and galectins contribute to immune evasion and cancer progression. Considering the resistance towards ICIs, current and prospective approaches for targeting glycan-lectin circuits and future prospects of these endeavors in harnessing the full potential of GNVs will also be highlighted.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of uniform biodegradable microcages with predesigned shape printed from microarrays for sustained release of small hydrophilic molecules. 由微阵列打印的具有预先设计形状的均匀可生物降解微笼的制造，用于持续释放小亲水分子。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-27 DOI: 10.1039/d5bm00154d

Jiaxin Zhang, Rui Sun, Valeriya Kudryavtseva, David J Gould, Gleb B Sukhorukov

{"title":"Fabrication of uniform biodegradable microcages with predesigned shape printed from microarrays for sustained release of small hydrophilic molecules.","authors":"Jiaxin Zhang, Rui Sun, Valeriya Kudryavtseva, David J Gould, Gleb B Sukhorukov","doi":"10.1039/d5bm00154d","DOIUrl":"https://doi.org/10.1039/d5bm00154d","url":null,"abstract":"Drug delivery vehicles have aroused increasing attention over the years due to their ability to protect and control the release of encapsulated cargo. However, several challenges significantly limit their wide applications including poor size distribution, uncontrollable size and shape, and leakage of loaded small hydrophilic cargos. This work introduces a novel and scalable microarray-based printing technique for preparing uniform biodegradable \"microcages\" with predesigned shapes for encapsulating and controlling the release of small hydrophilic molecules. The drugs encapsulated in the microcage are centrally located within solid microparticles without being exposed to the surface or dispersed throughout the polymer matrix. Here, 5(6)-carboxyfluorescein (CF) as a small and hydrophilic model drug are successfully loaded into polylactide acid (PLA) microcages with the dry loading method. Additionally, blending polycaprolactone (PCL) with PLA increases the permeability of the microcage polymer shells for controlled release. A higher PCL content results in a faster release rate of the encapsulated drug. Approximately 28 pg of CF particles can be encapsulated within individual microcages. This microcage printing technique provides a novel, scalable method for producing uniform biodegradable microcages, extending microprinting beyond microfilms and microparticles. A unique dry loading approach, independent of drug solubility, further broadens its utility for diverse biomedical applications.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PISA printing perfusable microcapillaries. PISA打印可灌注毛细血管。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-27 DOI: 10.1039/d5bm00547g

Aaron Priester, Jimmy Yeng, Yuwei Zhang, David Christofferson, Risheng Wang, Anthony J Convertine

引用次数: 0

Removal of expression of concern: A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma. 去除担忧的表达：一种缺氧可解离的siRNA纳米平台，用于增效增强胶质母细胞瘤的化疗。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-20 DOI: 10.1039/d5bm90042e

Yandong Xie, Xueying Lu, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu

引用次数: 0

Engineering blood-brain barrier microphysiological systems to model Alzheimer's disease monocyte penetration and infiltration. 工程血脑屏障微生理系统模拟阿尔茨海默病单核细胞渗透和浸润。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-05-20 DOI: 10.1039/d5bm00204d

Longjun Gu, Xiangdi Mao, Chunhui Tian, Yang Yang, Kaiyuan Yang, Scott G Canfield, Donghui Zhu, Mingxia Gu, Feng Guo

{"title":"Engineering blood-brain barrier microphysiological systems to model Alzheimer's disease monocyte penetration and infiltration.","authors":"Longjun Gu, Xiangdi Mao, Chunhui Tian, Yang Yang, Kaiyuan Yang, Scott G Canfield, Donghui Zhu, Mingxia Gu, Feng Guo","doi":"10.1039/d5bm00204d","DOIUrl":"https://doi.org/10.1039/d5bm00204d","url":null,"abstract":"Alzheimer's disease (AD) is a progressive and neurodegenerative disease, predominantly causing dementia. Despite increasing clinical evidence suggesting the involvement of peripheral immune cells such as monocytes in AD pathology, the dynamic penetration and infiltration of monocytes crossing blood-brain barrier (BBB) and inducing neuroinflammation is largely understudied in an AD brain. Herein, we engineer BBB-like microphysiological system (BBB-MPS) models for recapitulating the dynamic penetration and infiltration of monocytes in an AD patient's brain. Each BBB-MPS model can be engineered by integrating a functional BBB-like structure on a human cortical organoid using a 3D-printed device within a well of a plate. By coculturing these BBB-MPS models with monocytes from AD patients and age-matched healthy donors, we found that AD monocytes exhibit significantly greater BBB penetration and brain infiltration compared to age-matched control monocytes. Moreover, we also tested the interventions including Minocycline and Bindarit, and found they can effectively inhibit AD monocyte infiltration, subsequently reducing neuroinflammation and neuronal apoptosis. We believe these scalable and user-friendly BBB-MPS models may hold promising potential in modeling and advancing therapeutics for neurodegenerative and neuroinflammatory diseases.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0