3D printed bioceramic scaffolds with fully interconnected channel networks for enhanced vascularized bone regeneration.

IF 5.8 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Tao Zhang, Lifei Huang, Xiaonan Zhang, Jiali Guo, Yunming Shen, Yongxiang Luo
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引用次数: 0

Abstract

Bioceramics have emerged as some of the most widely utilized and promising biomaterials for bone repair. The structural morphology of bioceramic scaffolds plays a critical role in determining their overall performance. Strategic morphological design and optimization have been demonstrated to substantially augment therapeutic outcomes. Herein, in this study, we present a strategy for fabricating β-tricalcium phosphate (β-TCP) bioceramic scaffolds featuring a dual-pore architecture comprising fully interconnected hollow channel networks and open macropores, achieved through extrusion-based 3D printing coupled with surface crosslinking. The manufacturing process enables simultaneous structural optimization and bioactive ion incorporation (e.g., Cu2+, Sr2+) during surface crosslinking. Comparative in vitro and in vivo evaluations revealed that the interconnected channel system significantly enhanced mass transport efficiency and cellular infiltration, leading to superior bone tissue ingrowth and vascularization compared to both non-channeled scaffolds and those with non-interconnected channels fabricated by coaxial 3D printing. This work establishes the following advances: integration of macropores with fully interconnected channel networks in bioceramic scaffolds using extrusion-based additive manufacturing, and demonstration of enhanced vascularized osteogenesis through optimized structural design. The findings provide insights into the rational design of advanced bioceramic scaffolds for functional bone regeneration.

具有完全互联通道网络的3D打印生物陶瓷支架,用于增强血管化骨再生。
生物陶瓷已成为骨修复中应用最广泛和最有前途的生物材料之一。生物陶瓷支架的结构形态对其整体性能起着至关重要的作用。策略形态设计和优化已被证明可以大大提高治疗效果。在此,在本研究中,我们提出了一种制造β-磷酸三钙(β-TCP)生物陶瓷支架的策略,该支架具有双孔结构,包括完全互连的空心通道网络和开放的大孔,通过基于挤压的3D打印加上表面交联实现。该制造工艺能够在表面交联过程中同时实现结构优化和生物活性离子掺入(例如,Cu2+, Sr2+)。体外和体内对比研究表明,与非通道支架和同轴3D打印的非通道支架相比,互联通道系统显著提高了质量运输效率和细胞浸润,导致骨组织长入和血管化。这项工作建立了以下进展:利用基于挤压的增材制造技术将生物陶瓷支架中的大孔与完全互联的通道网络整合在一起,并通过优化的结构设计展示了增强的血管化成骨。该研究结果为合理设计先进的生物陶瓷支架以实现功能性骨再生提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomaterials Science
Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.50%
发文量
556
期刊介绍: Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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