Biomaterials Science最新文献_第2页

Correction: Hybrid cell membranes camouflage liposomes containing payloads to improve breast cancer chemo and photodynamic therapy. 更正：混合细胞膜伪装含有有效载荷的脂质体，改善乳腺癌化疗和光动力疗法。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-16 DOI: 10.1039/d4bm90100b

Chengfang Wang, Size Wu

引用次数: 0

Antibacterial and safe chitosan-graphene hydrogel films: a promising nanotherapeutic for Staphylococcus aureus wound infections.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-13 DOI: 10.1039/d4bm01276c

Priyadarshani Choudhary, Baskaran Ramalingam, Somashree Bose, Sujoy K Das

{"title":"Antibacterial and safe chitosan-graphene hydrogel films: a promising nanotherapeutic for Staphylococcus aureus wound infections.","authors":"Priyadarshani Choudhary, Baskaran Ramalingam, Somashree Bose, Sujoy K Das","doi":"10.1039/d4bm01276c","DOIUrl":"https://doi.org/10.1039/d4bm01276c","url":null,"abstract":"Pathogenic bacterial growth at wound sites, particularly Staphylococcus aureus, poses a serious threat during trauma. Delayed treatment can lead to increased inflammation and severe tissue damage. In this study, a chitosan cross-linked polycationic peptide-conjugated graphene-silver (CGrAP) nanocomposite hydrogel film was developed as an antibacterial wound dressing to treat S. aureus infections. The CGrAP hydrogel was synthesized via a Schiff-base reaction between the ε-poly-L-lysine functionalized graphene-silver nanocomposite and chitosan, and then cast into a film. Its antibacterial action is due to electrostatic interactions and ROS generation, finally disrupting the bacterial cells. In vivo studies on Wistar rat model demonstrated superior bacterial eradication and wound healing compared to antibiotic treatment. The CGrAP hydrogel also showed excellent physicochemical properties, including porosity, water uptake and cytocompatibility with L929 fibroblast cells along with no skin irritation or acute dermal toxicity. These results suggest that, CGrAP nanocomposite hydrogel films have strong potential for antibacterial wound dressing development in chronic wound care.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance imaging contrast agents based on albumin nanoparticles.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-12 DOI: 10.1039/d4bm01226g

Yuan Yuan, Hui Gao, Sunmin Jiang, Qingjun You, Juan Zhou, Jinghua Chen

引用次数: 0

A metal-phenolic nanotuner induces cancer pyroptosis for sono-immunotherapy.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-10 DOI: 10.1039/d4bm01292e

Guohao Wang, Dongmei Wang, Huimin Tian, Lu Xia, Dongyan Shen, Zhanxiang Wang, Yunlu Dai

引用次数: 0

Correction: A biotin-stabilized HKUST-1/ADM scaffold for facilitating MSC endothelial differentiation and vascularization in diabetic wound healing.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-09 DOI: 10.1039/d4bm90094d

Qiong Zhang, Linghong Kong, Qi Wang, Hui Wang, Yongzhen Yang, Jinping Fu, Yue Zhang, Jianyue Dong, Changchun Zeng, Hanping Liu

引用次数: 0

Metabolic labeling and targeted modulation of adipocytes.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-09 DOI: 10.1039/d4bm01352b

Yueji Wang, Yang Bo, Yusheng Liu, Jiadiao Zhou, Daniel Nguyen, Dhyanesh Baskaran, Yuan Liu, Hua Wang

{"title":"Metabolic labeling and targeted modulation of adipocytes.","authors":"Yueji Wang, Yang Bo, Yusheng Liu, Jiadiao Zhou, Daniel Nguyen, Dhyanesh Baskaran, Yuan Liu, Hua Wang","doi":"10.1039/d4bm01352b","DOIUrl":"https://doi.org/10.1039/d4bm01352b","url":null,"abstract":"Adipocytes play a critical role in energy storage and endocrine signaling and are associated with various diseases such as cancer and diabetes. Facile strategies to engineer adipocytes have long been pursued for elucidating adipocyte biology and developing adipocyte-based therapies. Herein, we report metabolic glycan labeling of adipocytes and subsequent targeted modulation of adipocytes via click chemistry. We show that azido tags expressed on the surface of adipocytes can persist for over 4 days. By conjugating dibenzocyclooctyne (DBCO)-cargos onto azido-labeled adipocytes via click chemistry, the cargos can be retained on the adipocyte membrane for over 12 hours. We further show that signaling molecules including adiponectin, calreticulin, mannose-binding lectin 2, and milk fat globule-EGF factor 8 protein can be conjugated to adipocytes to orchestrate their phagocytosis by macrophages. The azido-labeled adipocytes grafted into mice can also mediate targeted conjugation of DBCO-cargos in vivo. This adipocyte labeling and targeting technology will facilitate the development of adipocyte-based therapies and provides a new platform for manipulating the interaction between adipocytes and other types of cells.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 3D bioprinted adhesive tissue engineering scaffold to repair ischemic heart injury.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-06 DOI: 10.1039/d4bm00988f

Shuai Chen, Lindan Tan, Vahid Serpooshan, Haifeng Chen

{"title":"A 3D bioprinted adhesive tissue engineering scaffold to repair ischemic heart injury.","authors":"Shuai Chen, Lindan Tan, Vahid Serpooshan, Haifeng Chen","doi":"10.1039/d4bm00988f","DOIUrl":"10.1039/d4bm00988f","url":null,"abstract":"Adhesive tissue engineering scaffold (ATES) devices can be secured on tissues by relying on their intrinsic adhesive properties, hence, avoiding the complications such as host tissue/scaffold damage that are associated with conventional scaffold fixation methods like suturing or bioglue. This study introduces a new generation of three-dimensional (3D) bioprinted ATES systems for use as cardiac patches to regenerate the adult human heart. Tyramine-modified methacrylated hyaluronic acid (HAMA-tyr), gelatin methacrylate (GelMA), and gelatin were used to create the hybrid bioink formulation with self-adhesive properties. ATESs were bioprinted and further modified to improve the adhesion properties. In-depth characterization of printing fidelity, pore size, mechanical properties, swelling behavior, as well as biocompatibility was used to create ATESs with optimal biological function. Following in vitro testing, the ATESs were tested in a mouse model of myocardial infarction to study the scaffold adhesive strength in biological milieu. The method developed in this study can be used to manufacture off-the-shelf ATESs with complex cellular and extracellular architecture, with robust potential for clinical translation into a variety of personalized tissue engineering and regenerative medicine applications.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilizing photosynthetic oxygen-releasing biomaterials to modulate blood vessel growth in the chick embryo chorioallantoic membrane.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-05 DOI: 10.1039/d4bm00880d

Zhaojun Wang, Xiaoping Miao, Xizhi Wu, Yongqi Wu, Tengteng Han, Yude Su, Peng Liu, Zhiqiang Zhu, Ronald X Xu

{"title":"Utilizing photosynthetic oxygen-releasing biomaterials to modulate blood vessel growth in the chick embryo chorioallantoic membrane.","authors":"Zhaojun Wang, Xiaoping Miao, Xizhi Wu, Yongqi Wu, Tengteng Han, Yude Su, Peng Liu, Zhiqiang Zhu, Ronald X Xu","doi":"10.1039/d4bm00880d","DOIUrl":"https://doi.org/10.1039/d4bm00880d","url":null,"abstract":"Effective vascularization is crucial for the success of tissue engineering and is influenced by numerous factors. The present work focuses on investigating the effect of a substance, cyanobacteria-loaded oxygen-releasing hydrogel, on vascularization and verifying the effect of photosynthetic-oxygen-releasing biomaterials containing a cyanobacteria hydrogel on angiogenesis, using the chick chorioallantoic membrane (CAM) as a model system. On the eighth day of embryonic development, cyanobacterial microspheres were placed on the CAM and maintained in a light incubator under appropriate growth and photosynthesis conditions. The effect of cyanobacterial microspheres on vascularization was evaluated from the eighth day of embryonic development. The carrier material used to prepare the microspheres was a calcium alginate hydrogel, which is biocompatible for maintaining embryonic vitality. The article studied the preparation method, the optimal process, and the specific effects of in vivo co-culture on CAM vascularization and development. The data indicate that our prepared photosynthetic oxygen-releasing blue-green algal microspheres have the potential for symbiosis with tissues by supplying oxygen to tissues and inducing vascular growth through photosynthetic oxygen release. This research opens new avenues for applying cyanobacterial microspheres, a novel biological oxygen-releasing material, in regenerative medicine.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-04 DOI: 10.1039/d4bm90089h

Tian Zhang, Yajun Wang, Xianbin Ma, Cuilan Hou, Shuangyu Lv, Die Jia, Yi Lu, Peng Xue, Yuejun Kang, Zhigang Xu

引用次数: 0

Expression of concern: An ‘on-demand’ photothermal antibiotic release cryogel patch: evaluation of efficacy on an ex vivo model for skin wound infection

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-04 DOI: 10.1039/D4BM90090A

Léa Rosselle, Anna Rita Cantelmo, Alexandre Barras, Nadia Skandrani, Michael Pastore, Duygu Aydin, Laura Chambre, Rana Sanyal, Amitav Sanyal, Rabah Boukherroub and Sabine Szunerits

引用次数: 0