Biomaterials Science最新文献_第2页

Self-assembled carrier-free formulations based on medicinal and food active ingredients. 基于药用和食品活性成分的自组装无载体配方。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-11-11 DOI: 10.1039/d4bm00893f

Yuan Hao, Haixia Ji, Li Gao, Zhican Qu, Yinghu Zhao, Jiahui Chen, Xintao Wang, Xiaokai Ma, Guangyu Zhang, Taotao Zhang

{"title":"Self-assembled carrier-free formulations based on medicinal and food active ingredients.","authors":"Yuan Hao, Haixia Ji, Li Gao, Zhican Qu, Yinghu Zhao, Jiahui Chen, Xintao Wang, Xiaokai Ma, Guangyu Zhang, Taotao Zhang","doi":"10.1039/d4bm00893f","DOIUrl":"https://doi.org/10.1039/d4bm00893f","url":null,"abstract":"The popularity of medicinal plants, which have a unique system and are mostly used in compound form for the prevention and treatment of a wide range of diseases, is growing worldwide. In recent years, with advances in chemical separation and structural analysis techniques, many of the major bioactive molecules of medicinal plants have been identified. However, the active ingredients in medicinal plants often possess chemical characteristics, including poor water solubility, stability and bioavailability, which limit their therapeutic applications. To address this problem, self-assembly of small molecules from medicinal food sources provides a new strategy. Driven by various types of acting forces, medicinal small molecules with modifiable groups, multiple sites of action, hydrophobic side chains, and rigid backbones with self-assembly properties are able to form various supramolecular network hydrogels, nanoparticles, micelles, and other self-assemblies. This review first summarizes the forms of self-assemblies such as supramolecular network hydrogels, nanoparticles, and micelles at the level of the action site, and discusses the recent studies on the active ingredients in medicinal plants that can be used for self-assembly, in addition to summarizing the advantages of self-assemblies for a variety of disease applications, including wound healing, antitumor, anticancer, and diabetes mellitus. Finally, the problems of self-assemblers and the possible directions for future development are presented. We firmly believe that self-assemblers have the potential to develop effective compounds from drug-food homologous plants, providing valuable information for drug research and new strategies and perspectives for the modernization of Chinese medicine.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-dimensional structured PLCL/ADM bioactive aerogel for rapid repair of full-thickness skin defects. 用于快速修复全厚皮肤缺损的三维结构 PLCL/ADM 生物活性气凝胶。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-11-11 DOI: 10.1039/d4bm01214c

Xuchao Ning, Runjia Wang, Na Liu, Yong You, Yawen Wang, Jing Wang, Yuanfei Wang, Zhenyu Chen, Haiguang Zhao, Tong Wu

{"title":"Three-dimensional structured PLCL/ADM bioactive aerogel for rapid repair of full-thickness skin defects.","authors":"Xuchao Ning, Runjia Wang, Na Liu, Yong You, Yawen Wang, Jing Wang, Yuanfei Wang, Zhenyu Chen, Haiguang Zhao, Tong Wu","doi":"10.1039/d4bm01214c","DOIUrl":"https://doi.org/10.1039/d4bm01214c","url":null,"abstract":"The failure to treat deep skin wounds can result in significant complications, and the limitations of current clinical treatments highlight the pressing need for the development of new deep wound healing materials. In this study, a series of three-dimensional structured PLCL/ADM composite aerogels were fabricated by electrospinning and subsequently characterized for their microstructure, compression mechanics, exudate absorption, and hemostatic properties. Additionally, the growth of HSFs and HUVECs, which are involved in wound repair, was observed in the aerogels. The composite aerogel was subsequently employed in wound repair experiments on rat full-thickness skin with the objective of observing the wound healing rate and examining histological utilizing H&E, Masson, CD31, and COL-I staining. The findings indicated that the PLCL/ADM composite aerogel with a 10% concentration exhibited uniform pore size distribution, a good three-dimensional structure, and compression properties comparable to those of human skin, which could effectively absorb exudate and exert hemostatic effect. In vivo experiment results demonstrated that the aerogel exhibited superior efficacy to conventional oil-gauze overlay therapy and ADM aerogel in promoting wound healing and could facilitate rapid, high-quality in situ repair of deep wounds, thereby offering a novel approach for skin tissue engineering and clinical wound treatment.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aptamers in dentistry: diagnosis, therapeutics, and future perspectives. 牙科中的适配体：诊断、治疗和未来展望。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-11-11 DOI: 10.1039/d4bm01233j

Yang Yang, Zhen Yang, Hao Liu, Yongsheng Zhou

引用次数: 0

GelMA/tannic acid hydrogel decorated polypropylene mesh facilitating regeneration of abdominal wall defects. GelMA/单宁酸水凝胶装饰聚丙烯网片促进腹壁缺损再生。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-11-11 DOI: 10.1039/d4bm01066c

Haonan Huang, Fuxin Tang, Wenchang Gan, Ruibing Li, Zehui Hou, Taicheng Zhou, Ning Ma

{"title":"GelMA/tannic acid hydrogel decorated polypropylene mesh facilitating regeneration of abdominal wall defects.","authors":"Haonan Huang, Fuxin Tang, Wenchang Gan, Ruibing Li, Zehui Hou, Taicheng Zhou, Ning Ma","doi":"10.1039/d4bm01066c","DOIUrl":"https://doi.org/10.1039/d4bm01066c","url":null,"abstract":"Polypropylene (PP) mesh is a widely used prosthetic material in hernia repair due to its excellent mechanical properties and appropriate biocompatibility. However, its application is limited due to severe adhesion between the mesh and the abdominal viscera, leading to complications such as chronic pain, intestinal obstruction, and hernia recurrence. Currently, building anti-adhesive PP mesh remains a formidable challenge. In this work, a novel anti-adhesive PP mesh (PPM/GelMA/TA) was designed with a simple and efficient in situ gel of GelMA solution on the surface of PP mesh and further crosslinking of tannic acid (TA). It was demonstrated that PPM/GelMA/TA has good biocompatibility and excellent antioxidant property and effectively activates the polarization of macrophages toward the M2 phenotype in vitro. In addition, PPM/GelMA/TA could inhibit the growth of bacteria, which is of great significance for preventing postoperative infections. Furthermore, in the repair of full-thickness abdominal wall defects in rats, PPM/GelMA/TA reduced inflammation, promoted macrophage M2 polarization, and collagen deposition and angiogenesis so that does not cause any abdominal adhesion compared with PP mesh. As a result, our PPM/GelMA/TA shows an attractive prospect in the treatment of abdominal wall defect without adhesions.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of 3D tumor in vitro models with an immune microenvironment exhibiting similar tumor properties and biomimetic physiological functionality. 构建具有免疫微环境的三维肿瘤体外模型，展现类似的肿瘤特性和生物模拟生理功能。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-11-11 DOI: 10.1039/d4bm00754a

Yuhong Jiang, Lijuan Jin, Wenyu Liu, Hui Liu, Xiao Liu, Zhikai Tan

{"title":"Construction of 3D tumor in vitro models with an immune microenvironment exhibiting similar tumor properties and biomimetic physiological functionality.","authors":"Yuhong Jiang, Lijuan Jin, Wenyu Liu, Hui Liu, Xiao Liu, Zhikai Tan","doi":"10.1039/d4bm00754a","DOIUrl":"https://doi.org/10.1039/d4bm00754a","url":null,"abstract":"Tumors pose a serious threat to people's lives and health, and the complex tumor microenvironment is the biggest obstacle to their treatment. In contrast to the basic protein matrices typically employed in 2D or 3D cell culture systems, decellularized extracellular matrix (dECM) can create complex microenvironments. In this study, a combination of physicochemical methods was established to obtain liver decellularized extracellular matrix scaffolds (dLECMs) to provide mechanical support and cell adhesion sites. By co-culturing tumor cells, tumor-associated stromal cells and immune cells, an in vitro 3D tumor model with a biomimetic immune microenvironment was constructed. By utilizing microenvironment data obtained from human liver tumor tissues and refining the double seeding modeling process, 3D in vitro liver tumor-like tissues with a tumor immune microenvironment (TIME) were obtained and designated as reconstructed human liver cancer (RHLC). These tissues demonstrated similar tumor characteristics and exhibited satisfactory physiological functionality. The results of metabolic characterisation and mouse tumorigenicity testing verified that the constructed RHLC significantly increased in vitro drug resistance while also closely mimicking in vivo tissue metabolism. This opens up new possibilities for creating effective in vitro models for screening chemotherapy drugs.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox nanodrugs alleviate chronic kidney disease by reducing inflammation and regulating ROS. 氧化还原纳米药物通过减少炎症和调节 ROS 来缓解慢性肾病。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-11-11 DOI: 10.1039/d4bm00881b

Qin Wang, Xuedan Nie, Yifan Song, Haiyan Qiu, Liting Chen, He Zhu, Xueli Zhang, Mengru Yang, Xiaohui Xu, Peidan Chen, Chao Zhang, Jia Xu, Yeping Ren, Wenting Shang

{"title":"Redox nanodrugs alleviate chronic kidney disease by reducing inflammation and regulating ROS.","authors":"Qin Wang, Xuedan Nie, Yifan Song, Haiyan Qiu, Liting Chen, He Zhu, Xueli Zhang, Mengru Yang, Xiaohui Xu, Peidan Chen, Chao Zhang, Jia Xu, Yeping Ren, Wenting Shang","doi":"10.1039/d4bm00881b","DOIUrl":"https://doi.org/10.1039/d4bm00881b","url":null,"abstract":"Immune-mediated glomerular diseases lead to chronic kidney disease (CKD), primarily through mechanisms such as immune cell overactivation, mitochondrial dysfunction and imbalance of reactive oxygen species (ROS). We have developed an ultra-small nanodrug composed of Mn3O4 nanoparticles which is functionalized with biocompatible ligand citrate (C-Mn3O4 NPs) to maintain cellular redox balance in an animal model of oxidative injury. Furthermore, this ultra-small nanodrug, loaded with tacrolimus (Tac), regulated the activity of immune cells. We established a doxorubicin (DOX)-induced CKD model in SD rats using conditions of oxidative distress. The results demonstrate the ROS scavenging capability of Mn3O4 NPs, which mimics enzymatic activity, and the immunosuppressive effect of tacrolimus. This combination promotes targeted accumulation in the renal region with sustained drug release through the enhanced permeability and retention (EPR) effect. Tac@C-Mn3O4 protects the structural and functional integrity of mitochondria from oxidative damage while eliminating excess ROS to maintain cellular redox homeostasis, thereby suppressing the overexpression of pro-inflammatory cytokines to restore kidney function and preserve a normal kidney structure, reducing inflammation and regulating antioxidant stress pathways. This dual-pronged treatment strategy also provides novel strategies for CKD management and demonstrates substantial potential for clinical translational application.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH-Responsive doxorubicin-loaded magnetosomes for magnetic resonance-guided focused ultrasound real-time monitoring and ablation of breast cancer† pH-响应性阿霉素负载磁小体用于磁共振引导聚焦超声实时监测和消融癌症。

IF 6.6 3区医学

Biomaterials Science Pub Date : 2023-09-18 DOI: 10.1039/D3BM00789H

Na Tang, Yi Zhu, Ziwei Lu, Jiali Deng, Jiajing Guo, Xinyi Ding, Jingyi Wang, Rong Cao, An Chen, Zhongyi Huang, Hongwei Lu and Zhongling Wang

{"title":"pH-Responsive doxorubicin-loaded magnetosomes for magnetic resonance-guided focused ultrasound real-time monitoring and ablation of breast cancer†","authors":"Na Tang, Yi Zhu, Ziwei Lu, Jiali Deng, Jiajing Guo, Xinyi Ding, Jingyi Wang, Rong Cao, An Chen, Zhongyi Huang, Hongwei Lu and Zhongling Wang","doi":"10.1039/D3BM00789H","DOIUrl":"10.1039/D3BM00789H","url":null,"abstract":"MR-guided focused ultrasound surgery (MRgFUS) is driving a new direction in non-invasive thermal ablation therapy with spatial specificity and real-time temperature monitoring. Although widely used in clinical practice, it remains challenging to completely ablate the tumor margin due to fear of damaging the surrounding tissues, thus leading to low efficacy and a series of complications. Herein, we have developed novel pH-responsive drug-loading magnetosomes (STPSD nanoplatform) for increasing the T2-contrast and improved the ablation efficiency with a clinical MRgFUS system. Specifically, this STPSD nanoplatform is functionalized by pH-responsive peptides (STP-TPE), encapsulating superparamagnetic iron oxide (SPIO) and doxorubicin (DOX), which can cause drug release and SPIO deposition at the tumor site triggered by acidity and MRgFUS. Under MRgFUS treatment, the increased vascular permeability caused by hyperthermia can improve the uptake of SPIO and DOX by tumor cells, so as to enhance ultrasound energy absorption and further enhance the efficacy of chemotherapy to completely ablate tumor margins. Moreover, we demonstrated that a series of MR sequences including T2-weighted imaging (T2WI), contrast-enhanced T1WI imaging (T1WI C+), maximum intensity projection (MIP), volume rendering (VR) and ADC mapping can be further utilized to monitor the MRgFUS ablation effect in rat models. Overall, this smart nanoplatform has the capacity to be a powerful tool to promote the therapeutic MRgFUS effect and minimize the side effects to surrounding tissues.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 21","pages":" 7158-7168"},"PeriodicalIF":6.6,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10634620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of self-propelled micromotor for “hunting bacteria”† 自行式微型电机的构造，用于“猎菌”。

IF 6.6 3区医学

Biomaterials Science Pub Date : 2023-09-11 DOI: 10.1039/D3BM01175E

Yaping Zhang, Duoxin Zhang, Yuanze Geng, Yufeng He, Pengfei Song and Rongmin Wang

{"title":"Construction of self-propelled micromotor for “hunting bacteria”†","authors":"Yaping Zhang, Duoxin Zhang, Yuanze Geng, Yufeng He, Pengfei Song and Rongmin Wang","doi":"10.1039/D3BM01175E","DOIUrl":"10.1039/D3BM01175E","url":null,"abstract":"The inherent migration behavior of bacteria has inevitably impacted the advancement of the antibacterial treatment technology. Hunting bacteria, especially those with flagellates, requires self-propelled materials, which could kill bacteria autonomously. Herein, we designed and synthesized a self-propelled micromotor (SPM) tailed with poly(thiazole) to yield bimetallic organic frameworks (BiOFs), in which the assembly of BiOFs are similar to the “Newman projection”. The moving speed of the obtained SPM was 238.6 μm s−1 and presented excellent antibacterial activity; more than 90% bacteria were hunted and killed in flowing water. Its minimum inhibitory concentration (MIC) against E. coli and S. aureus was 3.2 and 0.4 mg mL−1, respectively, and its antibacterial activity was still retained after recycling for 5 times. Its antibacterial mechanism along with the contribution of the active units and flow rate was investigated. In summary, a novel self-propelled material for hunting bacteria was synthesized by an unprecedented and efficient strategy. This approach is anticipated to create huge possibilities for its applications in the fields of antibacterial, disinfection, and microdevices.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 20","pages":" 6775-6780"},"PeriodicalIF":6.6,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10200808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the application and biological mechanism of silicon nitride osteogenic properties: a review 氮化硅成骨性能的应用及生物学机制研究进展：综述。

IF 6.6 3区医学

Biomaterials Science Pub Date : 2023-09-11 DOI: 10.1039/D3BM00877K

Ziyi Liu, Ruijie Wang, Wenjing Liu, Yushan Liu, Xiaoli Feng, Fujian Zhao, Pei Chen, Longquan Shao and Mingdeng Rong

{"title":"Recent advances in the application and biological mechanism of silicon nitride osteogenic properties: a review","authors":"Ziyi Liu, Ruijie Wang, Wenjing Liu, Yushan Liu, Xiaoli Feng, Fujian Zhao, Pei Chen, Longquan Shao and Mingdeng Rong","doi":"10.1039/D3BM00877K","DOIUrl":"10.1039/D3BM00877K","url":null,"abstract":"Silicon nitride, an emerging bioceramic material, is highly sought after in the biomedical industry due to its osteogenesis-promoting properties, which are a result of its unique surface chemistry and excellent mechanical properties. Currently, it is used in clinics as an orthopedic implant material. The osteogenesis-promoting properties of silicon nitride are manifested in its contribution to the formation of a local osteogenic microenvironment, wherein silicon nitride and its hydrolysis products influence osteogenesis by modulating the biological behaviors of the constituents of the osteogenic microenvironment. In particular, silicon nitride regulates redox signaling, cellular autophagy, glycolysis, and bone mineralization in cells involved in bone formation via several mechanisms. Moreover, it may also promote osteogenesis by influencing immune regulation and angiogenesis. In addition, the wettability, surface morphology, and charge of silicon nitride play crucial roles in regulating its osteogenesis-promoting properties. However, as a bioceramic material, the molding process of silicon nitride needs to be optimized, and its osteogenic mechanism must be further investigated. Herein, we summarize the impact of the molding process of silicon nitride on its osteogenic properties and clinical applications. In addition, the mechanisms of silicon nitride in promoting osteogenesis are discussed, followed by a summary of the current gaps in silicon nitride mechanism research. This review, therefore, aims to provide novel ideas for the future development and applications of silicon nitride.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 21","pages":" 7003-7017"},"PeriodicalIF":6.6,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10634622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential effects of biomaterials on macrophage function and their signalling pathways 生物材料对巨噬细胞功能及其信号通路的潜在影响。

IF 6.6 3区医学

Biomaterials Science Pub Date : 2023-09-06 DOI: 10.1039/D3BM01213A

Fujun Zhu, Shaolian Wang, Xianglian Zhu, Caixiang Pang, Pei Cui, Fuwang Yang, Rongsheng Li, Qiu Zhan and Haiming Xin

{"title":"Potential effects of biomaterials on macrophage function and their signalling pathways","authors":"Fujun Zhu, Shaolian Wang, Xianglian Zhu, Caixiang Pang, Pei Cui, Fuwang Yang, Rongsheng Li, Qiu Zhan and Haiming Xin","doi":"10.1039/D3BM01213A","DOIUrl":"10.1039/D3BM01213A","url":null,"abstract":"The use of biomaterials in biomedicine and healthcare has increased in recent years. Macrophages are the primary immune cells that induce inflammation and tissue repair after implantation of biomaterials. Given that macrophages exhibit high heterogeneity and plasticity, the influence of biomaterials on macrophage phenotype should be considered a crucial evaluation criterion during the development of novel biomaterials. This review provides a comprehensive summary of the physicochemical, biological, and dynamic characteristics of biomaterials that drive the regulation of immune responses in macrophages. The mechanisms involved in the interaction between macrophages and biomaterials, including endocytosis, receptors, signalling pathways, integrins, inflammasomes and long non-coding RNAs, are summarised in this review. In addition, research prospects of the interaction between macrophages and biomaterials are discussed. An in-depth understanding of mechanisms underlying the spatiotemporal changes in macrophage phenotype induced by biomaterials and their impact on macrophage polarization can facilitate the identification and development of novel biomaterials with superior performance. These biomaterials may be used for tissue repair and regeneration, vaccine or drug delivery and immunotherapy.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 21","pages":" 6977-7002"},"PeriodicalIF":6.6,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10554853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0