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Naturally-derived injectable hydrogels for antitumor therapeutics. 用于抗肿瘤治疗的天然可注射水凝胶。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-23 DOI: 10.1039/d5bm00656b
Chi Zhang, Huixin Li, Ziqin Li, Kai Hao, Huayu Tian
{"title":"Naturally-derived injectable hydrogels for antitumor therapeutics.","authors":"Chi Zhang, Huixin Li, Ziqin Li, Kai Hao, Huayu Tian","doi":"10.1039/d5bm00656b","DOIUrl":"10.1039/d5bm00656b","url":null,"abstract":"<p><p>As novel localized drug delivery platforms, injectable hydrogels demonstrate significant potential in precision tumor therapy. By enabling spatiotemporally controlled drug release at target sites, they not only reduce systemic toxicity but also facilitate synergistic codelivery of chemotherapeutic agents, immunomodulators and gene therapy carriers. However, synthetic polymer-based hydrogel scaffolds face major challenges in clinical translation due to complex fabrication processes, potential immunogenicity and metabolic toxicity. In recent years, natural biomaterials such as chitosan, gelatin, and hyaluronic acid have emerged as preferred matrices for constructing antitumor hydrogel carriers, owing to their inherent biocompatibility, tunable biodegradability and clinical feasibility. This review systematically summarizes the structural advantages of natural biomaterials and their design principles in developing injectable hydrogels for antitumor applications, with particular focus on their cargo-loading mechanisms for diverse therapeutic agents. Additionally, it provides an in-depth discussion of key challenges in the clinical translation of natural material-based injectable hydrogels, aiming to guide the development of novel antitumor hydrogel platforms.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetic double network hydrogels of chondroitin sulfate and synthetic polypeptides for cartilage tissue engineering. 软骨组织工程用硫酸软骨素仿生双网水凝胶及合成多肽。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-23 DOI: 10.1039/d5bm00296f
Juhi Singh, Jacob C Kadir, Jason D Orlando, Stefanie A Sydlik
{"title":"Biomimetic double network hydrogels of chondroitin sulfate and synthetic polypeptides for cartilage tissue engineering.","authors":"Juhi Singh, Jacob C Kadir, Jason D Orlando, Stefanie A Sydlik","doi":"10.1039/d5bm00296f","DOIUrl":"https://doi.org/10.1039/d5bm00296f","url":null,"abstract":"<p><p>Articular cartilage defects are common, and the progressive deterioration of cartilage frequently results in the onset of osteoarthritis. However, the intrinsic regenerative capacity of articular cartilage is minimal. Synthetic therapeutic solutions for treating cartilage damage are being developed. However, current scaffolds and hydrogels employed in cartilage tissue engineering face limitations in promoting cellular activity and providing sufficient load-bearing strength. This is primarily due to suboptimal crosslinking methods for the synthetic scaffolds composed of natural proteins and glycosaminoglycans (GAGs). Synthetic polypeptides, owing to their customizable reactive functional groups, present an exciting opportunity to enhance crosslinking through both physical and chemical approaches. This study introduces a strategy for the development of injectable, shape-adaptive double network hydrogels that closely replicate the structural integrity and mechanical properties of native cartilage. These hydrogels are composed of photocrosslinkable GAGs, specifically methacrylated chondroitin sulfate A (CSMA), combined with a synthetic polypeptide, poly(L-lysine) (PLL). By varying the degree of polymerization (DP) of PLL and weight percentage of PLL in the composition, the hydrogels can be optimized for desired material properties. Varying DP of PLLs varies the molecular weight between crosslinks, thus leading to tunable rigidity (yield strength, ultimate compression strength, storage modulus) and toughness. We further this tunability through the integration of photoresponsive components, enabling controlled, non-invasive post-injection modifications. Initial testing indicates that these double network hydrogels exhibit significantly improved mechanical strength compared to hydrogels formed solely from CSMA, positioning them as strong candidates for minimally invasive cartilage defect repair. This innovative method offers the potential to accelerate recovery, restore joint function, and improve patients' overall quality of life.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coupling biophysical stimuli with functional scaffolds to overcome the current limitations of peripheral nerve regeneration: a review. 结合生物物理刺激与功能支架克服当前周围神经再生的局限性:综述。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-23 DOI: 10.1039/d4bm01531b
Larissa Ribeiro Lourenço, Erik Felix Dos Santos, Luccas Correa Teruel de Jesus, Ezegbe Chekwube Andrew, Francesco Baino, Roger Borges, Juliana Marchi
{"title":"Coupling biophysical stimuli with functional scaffolds to overcome the current limitations of peripheral nerve regeneration: a review.","authors":"Larissa Ribeiro Lourenço, Erik Felix Dos Santos, Luccas Correa Teruel de Jesus, Ezegbe Chekwube Andrew, Francesco Baino, Roger Borges, Juliana Marchi","doi":"10.1039/d4bm01531b","DOIUrl":"https://doi.org/10.1039/d4bm01531b","url":null,"abstract":"<p><p>Peripheral nerve injuries are common occurrences that can lead to the loss of sensibility and function, strongly impairing the patient's quality of life. The current techniques acting on nervous tissue regeneration rely on grafts, which are autologous or synthetic nerve guidance conduits produced by tissue engineering methods. However, even using these procedures, functional recovery is limited to a success rate of around 50%, which indicates the need for improvement in the peripheral nerve regeneration approach. Scaffolds with biomimetic characteristics and functional properties are increasingly being developed based on nanotechnology principles. Moreover, different external biophysical stimuli can be applied to achieve even better results. This review discusses the limiting factors that preclude complete nerve recovery and addresses four biophysical strategies to improve regeneration: electric, magnetic, light, and ion-release-based stimulations. The literature has shown that combining these techniques with nanomaterial-based nerve guidance conduits yields an improved nerve repair process. Furthermore, understanding the biological mechanisms underlying regenerative principles of nerve repair can drive new strategies of nerve tissue engineering under biophysical stimuli, overcoming current limitations of peripheral nerve regeneration.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CNTs-CaP/CS-AZ91D extracts induce CGRP production in dorsal root ganglion neurons to facilitate osteogenesis in rats. CNTs-CaP/CS-AZ91D提取物诱导大鼠背根神经节神经元生成CGRP促进成骨。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-23 DOI: 10.1039/d4bm01635a
Yun Tang, Jinghan Lin, Tingting Zhao, Lina Sun, Tingjiao Liu
{"title":"CNTs-CaP/CS-AZ91D extracts induce CGRP production in dorsal root ganglion neurons to facilitate osteogenesis in rats.","authors":"Yun Tang, Jinghan Lin, Tingting Zhao, Lina Sun, Tingjiao Liu","doi":"10.1039/d4bm01635a","DOIUrl":"https://doi.org/10.1039/d4bm01635a","url":null,"abstract":"<p><p>Clinical trials have proven the beneficial effect of biodegradable orthopedic composites on bone repair; however, the mechanisms underlying composite-induced bone formation have not yet been fully explored. AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and calcium phosphate (CaP)/chitosan (CS) (CNTs-CaP/CS-AZ91D) is a synthetic composite consisting of magnesium alloy, CNTs and CaP/CS. Its extracts induce the production of the calcitonin gene-related peptide (CGRP), a local neuropeptide that contributes to osteogenic differentiation, in dorsal root ganglion (DRG) neurons. This study was aimed at validating the upregulation of CGRP in CNTs-CaP/CS-AZ91D extract-induced DRG neurons. Besides, bone marrow-derived mesenchymal stem cells (BMSCs) showed greater osteogenic capacity after co-culture with CNTs-CaP/CS-AZ91D extract-induced DRG neurons, and this co-culture promoted autophagy in BMSCs to facilitate osteogenic differentiation. The dysregulation of CREB1/TRIM16/JAK1/STAT3 signaling was determined in BMSCs co-cultured with CNTs-CaP/CS-AZ91D extract-induced DRG neurons. However, all these results were counteracted by the knockdown of the CGRP receptor. <i>In vivo</i> study showed accelerated osteogenesis in the femur of CNTs-CaP/CS-AZ91D-implanted rats; however, this effect was inhibited by the CGRP receptor antagonist BIBN4096BS. In summary, this study highlights the critical role of the peripheral nervous system in osteogenesis and suggests the potential of CNTs-CaP/CS-AZ91D for improving bone formation in the future.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-atom silver-borophene hybrid hydrogels for electrically stimulated wound healing: a multifunctional antibacterial platform. 用于电刺激伤口愈合的单原子银-硼苯杂化水凝胶:多功能抗菌平台。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-20 DOI: 10.1039/d5bm00609k
Davlatov Salim Sulaymonovich, Normurot Fayzullaev, Rakhnamokhon Nazirova, Alisher Ishankulov, Mohammad Omidi, Bareq N Al-Nuaimi, Bobojonov Otabek Khakimboy Ugli, Kamalova Dilnavoz Ikhtiyorovna, Mamatqul Mamatqulov, Monireh Faraji
{"title":"Single-atom silver-borophene hybrid hydrogels for electrically stimulated wound healing: a multifunctional antibacterial platform.","authors":"Davlatov Salim Sulaymonovich, Normurot Fayzullaev, Rakhnamokhon Nazirova, Alisher Ishankulov, Mohammad Omidi, Bareq N Al-Nuaimi, Bobojonov Otabek Khakimboy Ugli, Kamalova Dilnavoz Ikhtiyorovna, Mamatqul Mamatqulov, Monireh Faraji","doi":"10.1039/d5bm00609k","DOIUrl":"10.1039/d5bm00609k","url":null,"abstract":"<p><p>Chronic wound healing demands next-generation biomaterials that includes antibacterial properties, electrical responsiveness, and tissue-regenerative capabilities. This study presents a multifunctional hydrogel that incorporates single-atom silver (Ag-SA) and two-dimensional borophene nanosheets (BNSs) within a PVA/chitosan matrix (PCAB). The atomically dispersed Ag sites exhibit highly localized bactericidal activity at a silver amount 50 times lower than those in traditional AgNP systems, thus reducing cytotoxicity and hemolysis to less than 5%. Concurrently, borophene nanosheets provide elevated electrical conductivity (0.45 ± 0.02 S cm<sup>-1</sup>), water retention, and matrix reinforcement, while facilitating real-time responsiveness under low-voltage stimulation (1 V). The PCAB-1 V hydrogel demonstrated robust antibacterial efficacy, eradicating more than 95% of <i>E. coli</i> and <i>S. aureus</i>, while markedly enhancing fibroblast proliferation (184.3 ± 3.6% viability). <i>In vivo</i> investigations utilizing a mouse full-thickness wound model demonstrated expedited wound closure (97.3%) and epithelium regeneration (124.5 μm) by Day 14. Statistical analysis validated substantial enhancements in all performance indicators (<i>p</i> < 0.001). This study emphasizes the synergistic interaction between Ag-SA and borophene, providing a low-toxicity, electroactive hydrogel substrate for enhanced wound care.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary acid-modified carbon dots loaded with paclitaxel for imaging-guided combination treatment of breast cancer. 唾液酸修饰碳点负载紫杉醇用于成像引导联合治疗乳腺癌。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-20 DOI: 10.1039/d5bm00139k
Zihan Zhu, Yan Zhang, Lianggan Luo, Xuan Shang, Xinli Fan, Wei Bian, Jing Wang, Xinjing Tang
{"title":"Salivary acid-modified carbon dots loaded with paclitaxel for imaging-guided combination treatment of breast cancer.","authors":"Zihan Zhu, Yan Zhang, Lianggan Luo, Xuan Shang, Xinli Fan, Wei Bian, Jing Wang, Xinjing Tang","doi":"10.1039/d5bm00139k","DOIUrl":"10.1039/d5bm00139k","url":null,"abstract":"<p><p>Due to the high morbidity and mortality, cancer has become a global health crisis, posing a great threat to human health. Traditional cancer treatments include surgery, chemotherapy and radiotherapy, but these methods can lead to serious adverse reactions. Therefore, it is of great significance to develop new and effective methods for cancer diagnosis and treatment. In this article, orange fluorescent carbon dots (CDs) were synthesized by the hydrothermal method using biogenic amines. Upon further surface modification with a salivary acid, a novel nanocomplex (CDs-SA-PTX) was prepared by loading the chemotherapeutic drug paclitaxel that could be released under a pH-responsive behavior. In addition, upon irradiation with a near-infrared laser, the temperature of the CDs-SA-PTX nanocomplexes increased to 45.7 °C, indicating a good photothermal effect with a conversion efficiency of 43.8%. In the cellular uptake experiment, CDs-SA-PTX exhibited good capability for nucleolar targeting similar to CDs. The cell viability experiment showed that CDs-SA-PTX together with laser irradiation demonstrated the best breast cancer cell killing ability than other groups. Further <i>in vivo</i> data indicated that CDs-SA-PTX could be efficiently enriched in tumor tissues and could almost completely inhibit tumor growth with laser irradiation. The nanocomplexes provide an ideally versatile platform with the advantages of simple ingredients, easy preparation, active targeting, imaging-guided photothermal therapy and chemotherapy.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic-based tissue engineering: principles, applications, and future prospects in biofabrication. 磁性组织工程:原理、应用及在生物制造中的未来展望。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-20 DOI: 10.1039/d5bm00160a
Hwanyong Choi, Jinah Jang
{"title":"Magnetic-based tissue engineering: principles, applications, and future prospects in biofabrication.","authors":"Hwanyong Choi, Jinah Jang","doi":"10.1039/d5bm00160a","DOIUrl":"10.1039/d5bm00160a","url":null,"abstract":"<p><p>Magnetic-based tissue engineering (MagTE) is a rapidly advancing interdisciplinary field that integrates magnetic materials and external magnetic fields with tissue engineering principles to manipulate cells, biomaterials, and biological environments for developing functional tissue substitutes. This review provides a comprehensive overview of MagTE, covering its fundamentals, applications, and future directions within the biofabrication domain. The magnetic properties of paramagnetic, ferromagnetic, ferrimagnetic, and superparamagnetic materials are discussed, along with mechanisms of magnetic actuation through forces and torques. MagTE applications are categorized into cell manipulation and stimulation. Direct and indirect manipulation techniques also enable precise control of cell alignment, patterning, and assembly into complex three-dimensional structures, such as cell sheets, spheroids, and organoids. Stimulation approaches-mechanical, thermal, electrical, and biochemical-exploit interactions between magnetic particles and external fields to elicit specific physiological responses and support tissue regeneration. We then conclude by addressing the current limitations of MagTE and proposing strategies to overcome these challenges.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repair of spinal cord injury using a time-specific four-dimensional multifunctional hydrogel with anti-inflammatory and neuronal differentiated microenvironments. 具有抗炎和神经元分化微环境的时间特异性四维多功能水凝胶修复脊髓损伤。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-18 DOI: 10.1039/d4bm01586j
Ruizhi Zhang, Chenbo Zou, Linlin Jiang, Baoshuai Bai, Chunlin Li, Chi Zhang, Hua Zhao, Shaohui Zong, Hao Li, Kai Jiang, Hengxing Zhou, Shiqing Feng
{"title":"Repair of spinal cord injury using a time-specific four-dimensional multifunctional hydrogel with anti-inflammatory and neuronal differentiated microenvironments.","authors":"Ruizhi Zhang, Chenbo Zou, Linlin Jiang, Baoshuai Bai, Chunlin Li, Chi Zhang, Hua Zhao, Shaohui Zong, Hao Li, Kai Jiang, Hengxing Zhou, Shiqing Feng","doi":"10.1039/d4bm01586j","DOIUrl":"https://doi.org/10.1039/d4bm01586j","url":null,"abstract":"<p><p>Spinal cord injury (SCI) is a severe central nervous system (CNS) condition that often leads to permanent disability. The repair of SCI presents significant challenges globally, primarily due to serious inflammatory damage in the early stage and limited neural regeneration in the long-term stage. In response to these challenges, this study developed a novel time-specific four-dimensional multifunctional SilMA hydrogel (4DMSH) that releases <i>Houttuynia cordata</i> extract (HCT) in the early stage of post-implantation to combat inflammation and a sustained release of neurotrophin-3 (NT-3) in the long-term stage to promote neuronal differentiation of endogenous neural stem cells (eNSCs) for neuronal regeneration. As expected, the time-specific 4DMSH significantly mitigated inflammatory responses, leading to a shift from a pro-inflammatory to a neural regenerative environment, and enhanced the differentiation of eNSCs into neurons, thereby effectively improving the recovery of motor, sensory, and autonomic functions after SCI. Therefore, this study presents a novel time-specific 4DMSH that creates anti-inflammatory and neuroactive microenvironments, contributing to efficient neuronal regeneration and SCI repair.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances and future perspectives of long-acting ophthalmic preparations (LAOPs) in clinical applications. 长效眼科制剂的临床应用进展及展望。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-18 DOI: 10.1039/d5bm00453e
Bo Wang, Meng Zhang, Weijiang Chen, Chengjing Yin, Hongtao Zhao, Guoguang Chen, Feng Cao
{"title":"Recent advances and future perspectives of long-acting ophthalmic preparations (LAOPs) in clinical applications.","authors":"Bo Wang, Meng Zhang, Weijiang Chen, Chengjing Yin, Hongtao Zhao, Guoguang Chen, Feng Cao","doi":"10.1039/d5bm00453e","DOIUrl":"https://doi.org/10.1039/d5bm00453e","url":null,"abstract":"<p><p>The intricate structure of ocular barriers significantly impedes drug penetration, leading to suboptimal efficacy of conventional ophthalmic formulations. Sustained/controlled-release long-acting ophthalmic preparations (LAOPs) address these limitations by prolonging drug retention, reducing dosing frequency, and enhancing therapeutic precision. This review categorizes clinically validated LAOPs by administration route, highlighting both market-approved products and investigational candidates in ongoing clinical trials. We detail mechanistic principles governing sustained-release systems while critically evaluating their translational challenges, including interspecies prediction gaps, long-term biocompatibility risks, and manufacturing reproducibility issues. The review concludes with a strategic roadmap to accelerate clinical translation of LAOPs, emphasizing molecular-level decoding of ocular disease pathways, computational modeling frameworks, bioengineered organoid models, and artificial intelligence (AI)-augmented manufacturing processes. These multidisciplinary advances position LAOPs to transform ophthalmic care through efficient, safe and personalized therapeutic paradigms. This targeted review aims to provide clinically relevant insights to guide future therapeutic development of LAOPs.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide hydrogels as slow-release formulations of protein therapeutics: case study of asparaginase-loaded hydrogels. 肽水凝胶作为蛋白质治疗的缓释制剂:天冬酰胺酶负载水凝胶的案例研究。
IF 5.8 3区 医学
Biomaterials Science Pub Date : 2025-06-17 DOI: 10.1039/d5bm00138b
Hue Vu, Evelien Peeters, Kenneth Hofkens, Katrien Vandemeulebroecke, Sara T'Sas, Charlotte Martin, Steven Ballet, Richard Hoogenboom, Steven Goossens, Tim Lammens, Maaike Van Trimpont, Annemieke Madder
{"title":"Peptide hydrogels as slow-release formulations of protein therapeutics: case study of asparaginase-loaded hydrogels.","authors":"Hue Vu, Evelien Peeters, Kenneth Hofkens, Katrien Vandemeulebroecke, Sara T'Sas, Charlotte Martin, Steven Ballet, Richard Hoogenboom, Steven Goossens, Tim Lammens, Maaike Van Trimpont, Annemieke Madder","doi":"10.1039/d5bm00138b","DOIUrl":"https://doi.org/10.1039/d5bm00138b","url":null,"abstract":"<p><p>In this study, hexamer peptide-based hydrogels were loaded with different model protein cargos and the release profiles investigated to explore the balance between injectability and loading capacity permitting the release of a therapeutically relevant dose. We demonstrate that the release of protein cargos from our hexamer peptide hydrogels depends on the stability of the hydrogel network, the mobility of the cargo to diffuse out of the network, and the interaction between the hydrogel network and the cargo. For the first time, our peptide hydrogels were used to develop an injectable sustained release formulation of a therapeutic enzyme, namely Erwinase®, an FDA-approved asparaginase for the treatment of acute lymphoblastic leukemia. We show that the current hexamer peptide-based hydrogels allow sufficient protein loading and sustained release of the fully active asparaginase enzyme both <i>in vitro</i> and <i>in vivo</i>. Altogether, this study describes how peptide hydrogels can be exploited to provide injectable slow-release formulations of biologics, including enzyme therapeutics, to enhance their clinical applicability.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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