Food & Function最新文献

{"title":"Lower plasma linoleic acids as a risk factor for gout: an integrated analysis of population-based cohort and genetic data.","authors":"Hao-Wei Tao, Zhong-Yue Liu, Wei Jiang, Meng-Yuan Miao, Jie-Qiong Lyu, Miao Zhao, Jie Zhu, Jin-Si Chen, Hong-Zhen Du, Zeng-Ning Li, Zhengbao Zhu, Jing Yang, Li-Qiang Qin, Wei Chen, Guo-Chong Chen","doi":"10.1039/d4fo00987h","DOIUrl":"https://doi.org/10.1039/d4fo00987h","url":null,"abstract":"<p><p><i>Background</i>: Gout is a nutrition-related, highly prevalent inflammatory arthritis with undesirable effects on the quality of life. The relationships between circulating fatty acids (FAs) and gout remain poorly understood. <i>Method</i>: We included 268 174 participants with plasma FAs measured using nuclear magnetic resonance at the baseline (2006-2010) from the UK Biobank, of which 15 194 participants had repeated measures of FAs between 2012 and 2013. Cox proportional hazards models were used to assess the association of the baseline and longitudinal changes in relative levels of plasma FAs (<i>%</i> total FAs) with incident gout. Mendelian randomization (MR) analyses were conducted to assess the potential causality of the examined association. <i>Results</i>: Over a median follow-up of 12.8 years, 5160 incident cases of gout occurred. Baseline polyunsaturated fatty acids (PUFAs), n-6 PUFAs, and linoleic acids (LAs) were inversely associated with incident gout (all <i>P</i>-trend values < 0.0001). Baseline monounsaturated fatty acids (MUFAs), n-3 PUFAs, and docosahexaenoic acids (DHAs) were positively associated with incident gout (all <i>P</i>-trend values < 0.0001). Longitudinal increments of n-6 PUFAs and LAs were associated with a lower risk of subsequent gout, whereas an increment of n-3 PUFAs was associated with a higher risk. In two-sample MR analyses, genetically determined higher levels of PUFAs, n-6 PUFAs, and LAs were associated with a decreased risk of gout (all <i>P</i> values < 0.05). <i>Conclusions</i>: Our findings consistently indicate a causal relationship of elevated levels of n-6 PUFAs, especially LAs, with a reduced risk of gout.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistant starch and tannic acid synergistically ameliorated dextran sulfate sodium-induced ulcerative colitis, particularly in the distal colon.","authors":"Zijun Liu, Shunjing Luo, Chengmei Liu, Xiuting Hu","doi":"10.1039/d4fo00531g","DOIUrl":"https://doi.org/10.1039/d4fo00531g","url":null,"abstract":"<p><p>We previously confirmed that tannic acid could delay the metabolism of resistant starch <i>in vitro</i>, which suggested that tannic acid might deliver resistant starch to the distal colon <i>in vivo</i>. Accordingly, co-supplementation of resistant starch and tannic acid might be beneficial for keeping the distal colon healthy. Thus, this study compared the effects of resistant starch, tannic acid and their mixtures on dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. It was found that the mixtures had a more profound effect on ameliorating DSS-induced ulcerative colitis than resistant starch or tannic acid. In particular, the mixtures reversed the histology damage of the distal colon induced by DSS, while resistant starch or tannic acid alone did not. The mixtures also had a stronger ability to resist oxidative stress and inhibit inflammation in the distal colon. These results suggested that resistant starch and tannic acid synergistically alleviated DSS-induced ulcerative colitis, particularly in the distal colon. On the other hand, DSS decreased the production of short-chain fatty acids and induced significant microbial disorder, while the administration of resistant starch, tannic acid and their mixtures reversed the above shifts caused by DSS. In particular, the mixtures exhibited stronger prebiotic activity, as indicated by the microbial composition and production of short-chain fatty acids. Therefore, it was inferred that tannic acid delivered resistant starch to the distal colon of mice, and thus the mixtures had stronger prebiotic activity. As a result, the mixtures effectively alleviated ulcerative colitis in the whole colon.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edible bird's nest regulates glucose and lipid metabolic disorders <i>via</i> the gut-liver axis in obese mice.","authors":"Wei Zhang, Meizhen Zhu, Xuncai Liu, Maoyao Que, Kelsang Dekyi, Linxi Zheng, Yichen Zhang, Youping Lv, Qunyan Fan, Xinyue Wang, Hongwei Li","doi":"10.1039/d4fo00563e","DOIUrl":"https://doi.org/10.1039/d4fo00563e","url":null,"abstract":"<p><p>Edible bird's nest (EBN) is a traditional food known for its nourishing and functional properties and is found to be involved in anti-oxidation, anti-aging, and anti-influenza mechanisms, immune regulation, and improving cardiovascular diseases, among others. However, the potential of EBN to improve glycolipid metabolism disorders in high-fat-diet induced obesity and the underlying mechanisms remain unexplored. We examined the effects of EBN on glycolipid metabolism in obese mice fed a high-fat diet. Male C57BL/6J mice were fed a high-fat diet for 8 weeks to establish an obesity model. The obese mice were selected and divided into six groups: two model control groups (normal and high-fat diets) and four intervention groups [Neu5Ac and low-, medium-, and high-dose EBN], with 12 mice in each group. After 10 weeks of continuous gavage intervention, only mice in the high-dose EBN intervention group had lower body weight and total fat content, especially visceral fat. Meanwhile, intervention with three doses of EBN reduced serum FBG, TC, LDL, Ox-LDL, IL-1β, IL-6, and TNF-α levels and increased serum HDL levels and energy expenditure. Using the high dosage as a paradigm, EBN intervention increased the sialic acid content in LDL, decreased TMAO in the liver, and increased GLP-1 levels in sera. EBN increased the colonic abundances of <i>Akkermansia</i>, <i>Lactobacillus</i>, and <i>Desulfovibrio</i> and reduced those of <i>Lysinibacillus</i> and <i>Bacillus</i>. The changes in the microbial community contribute to increasing colonic bile acids, reducing lipopolysaccharide synthesis to protect the intestinal barrier, and lowering inflammation levels. Changes were also observed in colonic transcripts and metabolites and liver gene transcripts and metabolites, which were mainly enriched in pathways of glycolipid metabolism, immune function amelioration, inflammatory signal mitigation, circadian rhythm, bile acid metabolism and insulin resistance. Therefore, EBN may enhance the gut microbiota and intestinal immunity, relieve chronic inflammation levels in serum, improve antioxidant capacity and circadian rhythm in the liver, promote bile acid metabolism, and decrease lipid absorption and lipid synthesis <i>via</i> the gut-liver axis. Consequently, this may reduce blood lipid and fat accumulation as well as improve islet function and reduce blood glucose levels.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urolithin B protects mice from diet-induced obesity, insulin resistance, and intestinal inflammation by regulating gut microbiota composition.","authors":"Peng Chen, Rong Wang, Jiexin Lei, Lihua Feng, Benhong Zhou","doi":"10.1039/d4fo02545h","DOIUrl":"https://doi.org/10.1039/d4fo02545h","url":null,"abstract":"<p><p>The increasing prevalence of obesity and type 2 diabetes (T2D) signifies the failure of conventional treatments for these diseases. The gut microbiota has been proposed as a key player in the pathophysiology of diet-induced T2D. Urolithin B (Uro B), a gut microbiota-derived polyphenol metabolite, exerts several beneficial health effects. In this study, we investigated the metabolic effects of Uro B on high-fat/high-sucrose (HFHS)-fed mice and determined whether its antidiabetic effects are related to the modulation of the gut microbiota. C57BL/6J mice were fed either a chow or HFHS diet. HFHS-fed mice were administered daily with either a vehicle (water) or different doses of Uro B (100 or 200 mg kg^-1) for eight weeks. The composition of the gut microbiota was assessed by 16S rRNA sequencing. The results showed that Uro B treatment reduced HFHS-induced weight gain and visceral obesity and decreased liver weight and triglyceride accumulation associated with blunted hepatic oxidative stress and inflammation. Furthermore, Uro B administration improved insulin sensitivity as revealed by improved insulin tolerance, a lower homeostasis model assessment of insulin resistance, and decreased glucose-induced hyperinsulinemia during the oral glucose tolerance test. Uro B treatment was found to lower the intestinal triglyceride content and alleviate intestinal inflammation and oxidative stress. Remarkably, Uro B treatment markedly increased the proportion of the mucin-degrading bacterium <i>Akkermansia</i> in metagenomic samples. In conclusion, Uro B exerts beneficial metabolic effects by alleviating HFHS diet-induced features of metabolic syndrome, which is associated with a proportional increase in the population of <i>Akkermansia</i> spp.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> fermentation reveals an interplay relationship between oat β-glucan and human gut <i>Bacteroides</i> and their potential role in regulating gut cytokines.","authors":"Junying Bai, Jing Wang, Mingcong Fan, Yan Li, Linhua Huang, Li Wang","doi":"10.1039/d4fo00775a","DOIUrl":"https://doi.org/10.1039/d4fo00775a","url":null,"abstract":"<p><p>Dietary oat β-glucan regulates the gut microbial composition and structure; however, the interplay relationship between oat β-glucan and the gut microbiota is unclear. In this study, we aim to investigate the interaction between oat β-glucan and human gut <i>Bacteroides</i>, a versatile carbohydrate utilizer, and explore the effect of their interaction on gut immunity homeostasis. The results of <i>in vitro</i> fermentation showed that oat β-glucan significantly increased the abundance of gut <i>Bacteroides</i> at the genus level. Then, <i>Bacteroides</i> strains were isolated from human gut microbiota and 9 strains of <i>Bacteroides</i> could grow on oat β-glucan and degrade oat β-glucan to reducing sugars. Notably, strains <i>Bacteroides xylanisolvens</i> Bac02 and <i>Bacteroides koreensis</i> Bac08 possessed the strongest degradation capacity towards oat β-glucan. Genome analysis and functional annotations suggested that <i>B. xylanisolvens</i> Bac02 and <i>B. koreensis</i> Bac08 contained abundant genes encoding glycoside hydrolases family 3 (GH3) and GH16, which might be responsible for β-glucan degradation. Moreover, cell experiments revealed that the metabolites from oat β-glucan fermentation by these 9 strains of <i>Bacteroides</i> could regulate the polarization of macrophages and maintain gut immunity homeostasis. Our study provides a novel insight into research on the interplay between dietary compounds and the gut microbiota.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between daily consumption of spicy food and bone mineral density in middle-aged and older adults: a cross-sectional study.","authors":"Wenhao Zhu, Haitao Zhang, Chunchun Yuan, Zhangyu Liao, Xianhui Zeng, Zhiwu Yang, Chenghong Zhou, Qi Shi, Dezhi Tang","doi":"10.1039/d4fo01893a","DOIUrl":"https://doi.org/10.1039/d4fo01893a","url":null,"abstract":"<p><p><i>Background</i>: Many studies have reported the effects of spicy food on human health, but no studies have been conducted on the impact of long-term spicy food consumption on bone mineral density (BMD). This study aimed to investigate the impact of daily consumption of spicy food on BMD in the population aged 50 years and older. <i>Methods</i>: This cross-sectional study was conducted from 2020 to 2022 in Jiangxi Province, China. This study investigated the differences in BMD between non-consumers and daily spicy food consumers in adults aged 50-85 years. A multiple linear regression model was used to investigate the association between spicy food consumption and BMD of the total lumbar spine (LS), femoral neck (FN), and total hip, as well as biochemical markers of bone metabolism (BMBM) levels. <i>Results</i>: The results showed that daily consumption of spicy food was negatively associated with total LS BMD (<i>β</i> = -0.013, <i>P</i> = 0.015). Subgroup analyses showed this negative association was more pronounced among smokers and drinkers compared to non-smokers (<i>β</i>: -0.006 <i>vs.</i> -0.042; <i>P</i> for interaction <0.05) and non-drinkers (<i>β</i>: -0.004 <i>vs.</i> -0.037; <i>P</i> for interaction <0.05). In addition, according to the daily frequency of spicy food consumption, the daily spicy food consumers were categorized into one meal per day, two meals per day, and three meals per day groups. Further analysis revealed that the negative association between spicy food and total LS BMD was progressively stronger as the frequency of daily consumption of spicy food increased (<i>P</i> for trend <0.05). For BMBM, daily consumption of spicy food was positively associated with serum PINP levels and negatively associated with serum Ca and serum Mg levels. <i>Conclusions</i>: Our study suggested that daily consumption of spicy food was associated with lower LS BMD in middle-aged and older Chinese adults, and this association was more pronounced in the smoking and drinking populations. The adverse effects of spicy food on LS BMD become progressively stronger with increasing frequency of daily consumption of spicy food. In addition, daily consumption of spicy food was associated with higher PINP levels and lower serum Ca and Mg levels.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underutilized Canadian wild berries as potential sources of lipophilic bioactive compounds with antihypertensive properties.","authors":"Chamali Kodikara, Thomas Netticadan, Sijo Joseph Thandapilly, Nandika Bandara, Champa Wijekoon","doi":"10.1039/d4fo00665h","DOIUrl":"https://doi.org/10.1039/d4fo00665h","url":null,"abstract":"<p><p>Traditional berries are small fruits and are widely distributed in the Canadian prairies. The current study investigates the lipophilic bioactive compounds such as fatty acids, phytosterols, and terpenes, and their bioactivities, such as lipid peroxidation, as well as the antihypertensive activities of fourteen underutilized Canadian wild berries. These berries include Saskatoon berries (<i>Amelanchier alnifolia</i>), gooseberries (<i>Ribes hirtellum</i>), wild grapes (<i>Vitis riparia</i>), blackcurrants (<i>Ribes nigrum</i>), redcurrants (<i>Ribes rubrum</i>), haskap berries (<i>Lonicera caerulea</i>), wild raspberries (<i>Rubus idaeus</i>), wild blueberries (<i>Vaccinium angustifolium</i>), chokeberries (<i>Aronia melanocarpa</i>), buckthorn (<i>Rhamnus cathartica</i>), highbush cranberries (<i>Viburnum trilobum</i>), chokecherries (<i>Prunus virginiana</i>), nannyberries (<i>Viburnum lentago</i>) and snowberries (<i>Symphoricarpos albus</i>). The fatty acids, phytosterols, and terpenes were identified using Gas Chromatography-Mass Spectrometry (GC-MS). Lipid peroxidation and the antihypertensive activity assessed by measuring the berries' angiotensin converting enzyme 1 (ACE1) inhibitory activity were determined using <i>in vitro</i> methods. Notably, wild grapes exhibited the highest (<i>p</i> < 0.05) total fat content (7659 ± 312 μg per g DW), followed by haskap berries (4650 ± 184 μg per g DW). Polyunsaturated fatty acids (PUFAs) were highest (<i>p</i> < 0.05) in wild grapes (74%). Predominant phytosterols and terpenes identified in Canadian wild berries included β-sitosterol, isofucosterol, phytol, and α-amyrin. Saskatoon berries and gooseberries showed a distinct phytosterol and terpene profile compared to the other wild berries. Snowberries demonstrated the highest (<i>p</i> < 0.05) lipid peroxidation and the lowest (<i>p</i> < 0.05) angiotensin converting enzyme (ACE1) activity. This research provides valuable insights into the lipophilic bioactive compounds and their potential activities <i>in vitro</i> of the Canadian wild berries, offering a foundation for further exploration and potential applications in the context of nutraceuticals and functional foods.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macronutrient digestion and polyphenol bioaccessibility in oat milk tea products: an <i>in vitro</i> gastrointestinal tract study.","authors":"Sirui Qin, Ruyi Li, David Julian McClements, Ying Chen, Zhihao Duan, Mianhong Chen, Yaping Dai, Liangkun Liao, Wei Zhou, Jihua Li","doi":"10.1039/d4fo01439a","DOIUrl":"https://doi.org/10.1039/d4fo01439a","url":null,"abstract":"<p><p>People are increasingly preparing milk tea using plant-based milks rather than cow's milk, <i>e.g.</i>, vegans, those with lactose intolerance, and those with flavor preferences. However, adding plant-based milks to tea may impact the digestion, release, and bioaccessibility of nutrients and nutraceuticals in both the tea and milk. In this study, oat milk tea model systems (OMTMSs) containing different fat and tea polyphenol concentrations were used to explore the impact of tea on macronutrient digestion in oat milk, as well as the impact of oat milk matrix on the polyphenol bioaccessibility in the tea. An <i>in vitro</i> gastrointestinal model that mimics the mouth, stomach, and small intestine was used. Tea polyphenols (>0.25%) significantly reduced the glucose and free fatty acids released from oat milk after intestinal digestion. Tea polyphenols (>0.10%) also inhibited protein digestion in oat milk during gastric digestion but not during intestinal digestion. The bioaccessibility of the polyphenols in the tea depended on the fat content of oat milk, being higher for medium-fat (3.0%) and high-fat (5.8%) oat milk than low-fat (1.5%) oat milk. Liquid chromatography-tandem mass spectrometry (UPLC-ESI-MS/MS) analysis showed that lipids improved the tea polyphenol bioaccessibility by influencing the release of flavonoids and phenolic acids from the food matrices. These results provide important information about the impact of tea on the gastrointestinal fate of oat milk, and <i>vice versa</i>, which may be important for enhancing the healthiness of plant-based beverages.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Porphyra haitanensis</i> glycoprotein regulates glucose homeostasis: targeting the liver.","authors":"Yujia Ou, Yuehong Guo, Haoyu Wang, Zebin Guo, Baodong Zheng","doi":"10.1039/d4fo01544d","DOIUrl":"https://doi.org/10.1039/d4fo01544d","url":null,"abstract":"<p><p>In this study, we investigated the effects of glycoprotein (PG)-mediated regulation of <i>Porphyra haitanensis</i> on liver glucose metabolism in hyperglycemic mouse models, and sought to establish the underlying mechanism, as determined by the changes in liver gene expression and metabolic profiles. The results showed that 30-300 mg kg^-1 PG upregulated the expression of the liver genes <i>Ins1</i>, <i>Ins2</i>, <i>Insr</i>, <i>Gys2</i>, <i>Gpi1</i>, <i>Gck</i>, and downregulated the expression of <i>G6pc</i>, <i>G6pc2</i>, and <i>G6pc3</i>, in a concentration-dependent manner. 300 mg kg^-1 PG downregulated the concentrations of glucose-related metabolites in the liver, but upregulated lactic acid, 2-aminoacetic acid, and glucose-1-phosphate concentrations. It was assumed that PG regulated liver glucose metabolism by enriching insulin secretion, glycolysis/gluconeogenesis, and the AMPK signaling pathway, and promoting insulin secretion, glycogen synthesis, and glycolysis. Our findings supported the development of <i>P. haitanensis</i> and its glycoproteins as novel natural antidiabetic compounds that regulated blood glucose homeostasis.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index mediates the association between four dietary indices and phenotypic age acceleration in adults: a cross-sectional study.","authors":"Jing Li, Zibo Wu, Sitong Xin, Yang Xu, Fengdan Wang, Yan Liu, Sizhe Wang, Yibo Dong, Yuangang Guo, Yu Han, Jing Zhao, Yuqi Gao, Mengzi Sun, Bo Li","doi":"10.1039/d4fo01088d","DOIUrl":"https://doi.org/10.1039/d4fo01088d","url":null,"abstract":"<p><p><i>Background</i>: Diet and body mass index (BMI) are widely recognized as being closely associated with aging. However, it remains unclear which dietary indices are associated with aging, and the extent to which BMI mediates the relationship between diet and aging. Therefore, this study investigates the mediating role of BMI in the association between various dietary indices and phenotypic age acceleration (PhenoAgeAccel). <i>Methods</i>: Data were sourced from the National Health and Nutrition Examination Survey (NHANES), using two 24 hour recall interviews to compute four dietary indices: the Dietary Inflammatory Index (DII), Healthy Eating Index-2020 (HEI-2020), Alternative Healthy Eating Index-2010 (AHEI-2010), and Composite Dietary Antioxidant Index (CDAI). Linear regression analyses and mediation analyses assessed the associations between dietary indices and PhenoAgeAccel and the mediating effects of BMI. <i>Z</i>-score transformations (zDII, zHEI-2020, zAHEI-2010, and zCDAI) were used to ensure comparability between different dietary indices. <i>Results</i>: After adjusting for covariates, the zHEI-2020, zAHEI-2010, and zCDAI were negatively associated with PhenoAgeAccel (<i>P</i> < 0.05), with <i>β</i> values being -0.36, -0.40, and -0.41, respectively. The zDII was positively associated with PhenoAgeAccel (<i>P</i> < 0.001) with a <i>β</i> value of 0.70. Mediation analyses suggested that BMI significantly mediated the relationships between these dietary indices and PhenoAgeAccel. The mediation proportions were 23.7% for zDII, 43.3% for zHEI-2020, 24.5% for zAHEI-2010, and 23.6% for zCDAI. <i>Conclusions</i>: This study indicates that all dietary indices and BMI were significantly associated with PhenoAgeAccel. In addition, BMI exhibited the highest mediation proportion in the relationship between HEI-2020 and PhenoAgeAccel.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}