Food & Function最新文献

{"title":"The interaction between various food components and intestinal microbiota improves human health through the gut-X axis: independently or synergistically.","authors":"Fenfa Li, Xichun Peng, Wenzhi Li","doi":"10.1039/d4fo04430d","DOIUrl":"https://doi.org/10.1039/d4fo04430d","url":null,"abstract":"<p><p>Food contains various components that improve health by affecting the gut microbiota, primarily by modulating its abundance or altering its diversity. Active substances in food have different effects on the gut microbiota when they act alone or in synergy, resulting in varying impacts on health. The bioactive compounds in food exert different effects on various gut microbiota through multiple pathways, thereby delaying or preventing different kinds of disease. The combination of two or more active compounds may have a synergistic effect, which can more effectively alter the gut microbiota and alleviate diseases through the microbiota-gut-organ axis. According to reports, multiple different food components have similar effects, some of which have been shown to have a synergistic effect on the gut microbiota to promote health. However, there is currently no systematic review of its synergistic effects and mechanisms. There may be more compounds with synergistic effects that have not yet been discovered, while their mechanisms of synergy and ways of impacting host health through the gut microbiota deserve further investigation. The purpose of this review is to systematically summarize the effects of different food components on intestinal flora and health, and further analyze the potential synergies between different food components. PubMed and Google Scholar databases were searched in this review.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Bifidobacterium animalis</i> subsp. <i>lactis</i> BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota.","authors":"Zhaochun Zhang, Jie Li, Ziyi Wan, Shuguang Fang, Yunjiao Zhao, Qian Li, Min Zhang","doi":"10.1039/d4fo06350c","DOIUrl":"https://doi.org/10.1039/d4fo06350c","url":null,"abstract":"<p><p>Probiotics, as health ingredients, have attracted widespread attention. However, due to the wide variety of probiotic species, their laxative effects and the underlying mechanisms remain elusive. In this study, we investigated the laxative effect of <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> BLa80 (at concentrations of 1.0 × 10⁸, 2.0 × 10⁸, and 4.0 × 10⁸ CFU per mL, with a dosage of 0.2 mL each) in mice, utilizing a functional constipation mouse model induced with loperamide hydrochloride (0.2 mL, 10 mg per kg BW) for 7 consecutive days. Meanwhile, a blank group (treated with 0.2 mL of 0.9% saline) and a positive control group (treated with mosapride at a dose of 5 mg per kg BW) were also set up. The body weight, fecal water content, intestinal propulsion rate, colon tissue histology, fecal microbial composition, serum indices, and colon mRNA levels of the mice were measured, employing histological and biochemical assays, GC-MS, RT-qPCR and 16S rRNA gene sequencing <i>etc</i>. Results showed BLa80 could accelerate intestinal peristalsis, maintain fecal moisture, prevent intestinal barrier disruption, increase short-chain fatty acid production, prevent gut microbe dysbiosis and constipation in mice. It also helped to keep the levels of 5-hydroxytryptamine (5-HT), motilin (MTL), and substance P (SP) normal, up-regulated the mRNAs of intestinal mucin 2 (MUC2), stem cell factor (SCF), and the tyrosine kinase receptor c-Kit, and down-regulated the mRNA of aquaporins (AQPs), especially at a high-dose. This study indicated that BLa80 held the potential to emerge as a novel ingredient in functional foods designed for constipation relief and as a treatment alternative.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of protein-rich multi-nutrient intervention on bone mineralization and development: insights from a randomized controlled trial in prepubertal children and a zebrafish experiment.","authors":"Xiaolong Xing, Xinyang Li, Yi Guo, Wentao Gu, Qisijing Liu, Jianhua Ma, Li Su, Yu Wang, Yanrong Zhao, Shuo Wang","doi":"10.1039/d4fo04240a","DOIUrl":"https://doi.org/10.1039/d4fo04240a","url":null,"abstract":"<p><p>High-protein foods and physical activity are crucial for bone growth in early life. This study first examined whether a protein-rich multi-nutrient intervention combined with rope-skipping training could prevent bone loss during winter in prepubertal children. A 10 week randomized controlled trial involving 120 children aged 9-12 years in rural northwestern China was conducted. Participants were assigned to a treatment group (protein-rich multi-nutritional drink plus rope-skipping training) or a control group (rope-skipping training only). Forearm bone mineral density (BMD) was measured at the baseline and week 10 of the trial, along with serum calcium, parathyroid hormone (PTH), insulin-like growth factor 1 (IGF-1), and bone turnover biomarkers. Second, we estimated the effects of three protein sources enriched in the drink, milk protein concentrates (MPC), collagen peptides (CP), and whey protein hydrolysates (WPH), on zebrafish backbone development. In children, BMD decreased in both groups, but the treatment group showed a smaller reduction and a positive intervention effect (relative change: 0.023 g cm^-2, <i>P</i> = 0.037). The treatment group also had a smaller increase in PTH (relative change: -8.53 ng L^-1, <i>P</i> = 0.012) and a smaller decrease in IGF-1 (relative change: 20.75 ng mL^-1, <i>P</i> = 0.076). No significant differences were found in bone turnover biomarkers. In zebrafish, MPC, CP, and WPH individually and synergistically promoted bone growth without adverse effects, as shown by dose-dependent increases in the backbone fluorescence intensity. These findings suggest that protein-rich multi-nutrient supplementation combined with rope-skipping training could prevent bone loss in prepubertal children during winter, potentially through changes in serum PTH and IGF-1, and highlight the synergistic effects of these proteins on bone development.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary phytosterol supplementation mitigates renal fibrosis <i>via</i> activating mitophagy and modulating the gut microbiota.","authors":"Fan Yang, Yingjie Gao, Siyi Xie, Wenjing Yang, Qiyan Wang, Wenqian Ye, Lu Sun, Jiangtao Zhou, XiuE Feng","doi":"10.1039/d4fo06043a","DOIUrl":"https://doi.org/10.1039/d4fo06043a","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) poses a significant global health challenge, primarily driven by renal fibrosis, with limited treatment options. Addressing this condition necessitates either targeted medical treatments or dietary interventions. Phytosterols (PS) are cholesterol-like bioactive compounds in various plant-based foods with antioxidant and anti-inflammatory effects. A CKD mouse model was established using folic acid (FA) and treated with dietary supplements of two PS, stigmasterol (Stig) and β-sitosterol (β-Sito). The effects and mechanisms of PS were investigated through biochemical indices, pathology, transcriptomics, and 16S rDNA sequencing. The results indicated that high-dose PS are more effective than low-dose PS and Losartan potassium (LP) in reducing renal fibrosis, restoring function, and modulating oxidative stress and inflammation, with no significant differences between high-dose Stig and β-Sito treatments. Gene Ontology (GO) enrichment analysis revealed that PS were significantly enriched in pathways related to the mitochondrial outer membrane, ubiquitin-protein ligase binding, and other cellular components and molecular processes. PS reduced the expression of TGF-β/Smad and cGAS/Sting1/TBK1 and activated PINK1/Parkin pathway proteins, thereby mitigating renal fibrosis in mice. CKD is often associated with imbalanced gut microbiota and compromised intestinal barriers. Our observations indicated that PS restored the intestinal barrier, altered the composition of the gut microbiota, and improved renal function in CKD mice. The present findings indicate that both Stig and β-Sito activate mitophagy <i>via</i> the PINK1/Parkin pathway and modulate the gut microbiota, thereby alleviating renal fibrosis. The findings provide solid and significant implications for developing effective application of PS supplementation in the management of CKD, presenting novel concepts and approaches for research and clinical treatment.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alleviation of hyperglycaemia and oxidative stress by fruit extracts of different cultivars of the cornelian cherry (<i>Cornus mas</i> L. and <i>Cornus mas</i> × <i>Cornus officinalis</i>) in rats with diabetes mellitus.","authors":"Iryna Brodyak, Anna Moroz, Karolina Bernacka, Alicja Z Kucharska, Nataliia Sybirna","doi":"10.1039/d4fo05426a","DOIUrl":"https://doi.org/10.1039/d4fo05426a","url":null,"abstract":"<p><p>The development of new cornelian cherry cultivars with stronger antidiabetic properties than those of previously studied <i>Cornus mas</i> L. extracts is essential. Accordingly, the aim of the present study was to assess the biological effects of fruit extracts derived from the 'Uholok' and 'Koralovyi' cultivars of <i>C. mas</i> and mix of two hybrids of <i>C. mas</i> × <i>C. officinalis</i> ('Jerzy' and 'Tomasz' cultivars) in rats with streptozotocin-induced diabetes mellitus. The quantitative and qualitative identification of bioactive substances in cornelian cherry fruits was conducted using HPLC-PDA. Fruit extracts from different cultivars were administered orally to rats with diabetes for 14 days at a dose of 20 mg per kg b.w. This resulted in a notable decrease in glucose-related parameters in the blood, proving the extracts' effectiveness as inhibitors of α-glucosidase activity. The fruit extract from the hybrids showed the most pronounced effect among the studied extracts with regard to these indicators. In addition, the fruit extracts demonstrated a positive corrective impact on the metabolites of glycolysis (pyruvate and L-lactate) and lactate dehydrogenase activity. The extracts produced antioxidant effect in diabetic rats by reducing oxidative stress biomarkers in plasma. Extracts from fruits of the 'Uholok' and 'Koralovyi' cultivars exhibited a higher efficiency than the extracts from <i>C. mas</i> 'Yantarnyi' and 'Flava' cultivars. The biological effects of the fruit extract from the 'Uholok' cultivar are comparable to those of the 'Podolski' cultivar. These findings contribute to the understanding of the antidiabetic effect of the studied extracts and indicate their potential application as promising drugs.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fermented wheat germ on the placenta of high-fat diet-induced obese maternal rats: morphology, metabolism, and nutrient transport.","authors":"Xiaolin Li, Yingyu Zhao, Jihong Huang","doi":"10.1039/d4fo05828c","DOIUrl":"https://doi.org/10.1039/d4fo05828c","url":null,"abstract":"<p><p>Maternal obesity impairs placental function, affecting fetal growth and long-term health. Although fermented wheat germ (FWG) provides health benefits, its impact on maternal obesity-related metabolic disorders and placental function remains unclear. This study investigated FWG's effects on placental morphology, metabolism, and nutrient transport in high-fat diet (HFD)-induced obese maternal rats. Wheat germ (WG) and FWG were administered from model induction, with a 45% HFD-fed for 10 weeks before conception and continued until gestational day 19.5. Results revealed that WG and FWG supplementation alleviated maternal metabolic abnormalities and mitigated placental structural damage. Additionally, this supplementation reduced placental lipid accumulation, oxidative stress, and inflammation while regulating nutrient transporter mRNA expression and inhibiting mTOR signaling activation. Compared with WG, FWG more effectively reduced maternal obesity and optimized placental nutrient transport. These findings suggest that FWG is a promising dietary intervention for disrupting the maternal obesity cycle and enhancing maternal-fetal health by alleviating obesity, mitigating metabolic dysfunction, and modulating placental morphology and function.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinoa bran polyphenol extract attenuates high-fat diet induced non-alcoholic fatty liver disease in mice.","authors":"Minjun Sun, Haoyuan Ma, Ying Miao, Meili Zhang","doi":"10.1039/d4fo02647k","DOIUrl":"https://doi.org/10.1039/d4fo02647k","url":null,"abstract":"<p><p>Quinoa bran is a by-product of quinoa processing and is rich in polyphenolic bioactives. Previous studies have shown that polyphenol compounds can help alleviate metabolic diseases, but studies on quinoa bran polyphenols intervening in non-alcoholic fatty liver disease (NAFLD) have not yet been reported. In this study, a C57BL/6J mouse NAFLD model was established using a high-fat diet (HFD) to explore the interventional effects of quinoa bran polyphenol extract (QBP) on NAFLD in mice. The results showed that QBP was effective in attenuating abnormal lipid metabolism and hepatic fat accumulation and reducing inflammation in NAFLD mice. 16S rRNA sequencing analysis showed that QBP regulated the composition of the gut microbiota by increasing the abundance of beneficial bacteria <i>Clostridium_innocuum_group</i>, <i>Clostridium_sensu_stricto_13</i>, <i>Ruminococcus_gnavus_group</i>, <i>Coriobacteriaceae_UCG_002</i> and <i>UBA1819</i>. Untargeted metabolomics identified 51 differential metabolites due to QBP supplementation. Functional predictions indicated that starch and sucrose metabolism and pentose and gluconate interconversion are key metabolic pathways for QBP to attenuate NAFLD, which may be influenced by the gut microbiota. These results demonstrated the potential application of QBP interventions for NAFLD.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of 3D-printed foods incorporating riboflavin-loaded whey protein isolate nanostructures: characterization and <i>in vitro</i> digestion.","authors":"João F Araújo, Jean-Michel Fernandes, Daniel Madalena, Raquel F S Gonçalves, Jorge M Vieira, Joana T Martins, António A Vicente, Ana C Pinheiro","doi":"10.1039/d4fo05102e","DOIUrl":"https://doi.org/10.1039/d4fo05102e","url":null,"abstract":"<p><p>3D printing has emerged as a groundbreaking technology, aiming to enhance sensory attributes and improving nutritional/functional aspects. Simultaneously, nano-delivery systems have emerged as an opportunity to protect bioactive compounds against degradation and improve their bioaccessibility. Therefore, a novel concept is underway, involving the 3D printing of perishable healthy foods previously fortified with bioactive compound-loaded nanostructures. As a model concept, whey protein isolate (WPI) nanostructures were associated with riboflavin with an efficiency of 59.2%. Carrot pastes with adequate printability, shape retention and rheological characteristics were formulated. Riboflavin-WPI loaded nanostructures were incorporated into carrot inks and submitted to a static <i>in vitro</i> digestion. There was a notable increase in riboflavin bioaccessibility (+23.1%), suggesting a synergistic interaction between WPI nanostructures and carrot matrix. These results may contribute to validating the use of WPI nanostructures as effective encapsulating systems allied with 3D food printing towards the development of functional foods with personalized structure and nutrition profile.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of different sugar substitutes: Mogroside V, stevioside, sucralose, and erythritol on intestinal health in a type 2 diabetes mellitus mouse.","authors":"Huaxue Huang, Sha Liu, Zhi Peng, Bin Wang, Shuang Zhan, Sirui Huang, Wei Li, Dai Liu, Xiulian Yang, Yizhun Zhu, Wenjun Xiao","doi":"10.1039/d4fo04446k","DOIUrl":"https://doi.org/10.1039/d4fo04446k","url":null,"abstract":"<p><p>Intestinal health disorders significantly contribute to the development of type 2 diabetes mellitus (T2DM). Sugar substitutes such as mogroside V (MOG), stevioside (ST), sucralose (TGS), and erythritol (ERT), are increasingly used in T2DM management as alternatives to sucrose (SUC). However, their effects on intestinal health in T2DM have not been fully compared. In the present study, we established a T2DM mouse model using a high-fat diet and streptozotocin injection. These mice were treated with equal doses of SUC, MOG, ST, TGS, or ERT for 4 weeks to evaluate the effects of these sugar substitutes on intestinal health in T2DM. T2DM mice exhibited increased intestinal permeability, reduced goblet cell numbers, elevated pro-inflammatory cytokine levels, and alterations in both gut microbiota and metabolite composition. After 4 weeks of treatment, MOG showed the most significant benefits. MOG activates the PI3K/AKT pathway, enhancing the expression of tight junction proteins, which improves intestinal barrier function and reduces permeability. This is accompanied by NF-κB inhibition, leading to reduced pro-inflammatory cytokine production and increased mucus secretion. These changes help maintain healthy gut microbiota and metabolites, preventing pathogenic bacteria from entering the bloodstream. ST downregulates NF-κB to alleviate intestinal inflammation and improves gut microbiota and metabolic homeostasis in T2DM. ERT has less beneficial effects. TGS and SUC reduce intestinal inflammation and have a better effect on the duodenum. However, TGS has a negative effect on the colon microbiota and metabolites, whereas SUC has a negative effect on the colon microbiota alone. MOG improved intestinal health in T2DM by modulating the PI3K/AKT and NF-κB pathways, whereas ST primarily modulated NF-κB to alleviate intestinal inflammation. Both treatments were effective, with MOG showing the best performance. Therefore, MOG can be considered a viable alternative to SUC for T2DM management.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent updates of probiotic dairy-based beverages.","authors":"Şevval Taşkoparan, Canan Altınay, H Barbaros Özer","doi":"10.1039/d4fo06322h","DOIUrl":"10.1039/d4fo06322h","url":null,"abstract":"<p><p>There is a rapid paradigm shift in the food consumption habits of consumers globally. The interest in healthier, safer, minimally processed and nature-identical foods is the driving force of this paradigm shift. Although the roots of this consumer trend go back further, especially the Covid-19 pandemic has contributed to the acceleration of this process. The effects of probiotics on human health have been known for many years. The commercial success of some probiotic microorganism strains, supported by clinical studies, is also evident. Probiotic microorganisms can be found in commercial products in a wide range of forms including powder, tablets or incorporated into liquid or solid food matrices. Milk and dairy products are suitable vehicles for the delivery of probiotics into the human body. Apart from well-established dairy-based probiotic foods including yogurt and yogurt-type beverages, in recent years some dairy products supplemented or enhanced with postbiotics and paraprobiotics are gaining popularity. The incorporation of next-generation probiotics in probiotic beverage formulations has also attracted the attention of researchers. The current state-of-the art for the utilization of next-generation probiotics, postbiotics and paraprobiotics in dairy-based probiotic beverages is the main focus of this review. Conventional milk-, whey- and buttermilk-based probiotic beverages are also covered.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}