Food & Function最新文献

{"title":"<i>Solanum lycopersicum</i> derived exosome-like nanovesicles alleviate restenosis after vascular injury through the Keap1/Nrf2 pathway.","authors":"Hechen Shen, Meng Zhang, Dachang Liu, Xiaoyu Liang, Yun Chang, Xiaomin Hu, Wenqing Gao","doi":"10.1039/d4fo03993a","DOIUrl":"https://doi.org/10.1039/d4fo03993a","url":null,"abstract":"<p><p>Despite the significant alleviation of clinical cardiovascular diseases through appropriate interventional treatments, the recurrence of vascular restenosis necessitating reoperation remains a substantial challenge impacting patient prognosis. Plant-derived exosome-like nanovesicles (PELNs) are integral to interspecies cellular communication, with their functions and potential applications garnering significant attention from the research community. This study extracted <i>Solanum lycopersicum</i>-derived exosome-like nanovesicles (SL-ELNs) and demonstrated their inhibition of PDGF-BB-induced proliferation, migration, and phenotypic transformation of vascular smooth muscle cells (VSMCs). Mechanistically, miRNA164a/b-5p within the SL-ELNs reduced the expression of Keap1 mRNA, thereby increasing nuclear translocation of Nrf2 and enhancing the expression of antioxidant genes to alleviate oxidative stress. In a mouse carotid artery injury model, it was further confirmed that miRNA164a/b-5p within the SL-ELNs could inhibit neointimal hyperplasia. These results suggest that SL-ELNs inhibit VSMCs proliferation, migration, and phenotypic transformation, and they might be potential therapeutic agents for the prevention or treatment of restenosis.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthocyanin-rich black wheat as a functional food for managing type 2 diabetes mellitus: a study on high fat diet-streptozotocin-induced diabetic rats.","authors":"Vandita Tiwari, Akhil Kamboj, Bhawna Sheoran, Era Chaudhary, Mona Yadav, Anita Kumari, Meena Krishania, Usman Ali, Apoorv Tiwari, Monika Garg, Archana Bhatnagar","doi":"10.1039/d4fo05065g","DOIUrl":"https://doi.org/10.1039/d4fo05065g","url":null,"abstract":"<p><p><i>Background</i>: Type 2 Diabetes Mellitus (T2DM) is associated with insulin resistance, hyperglycemia, and hyperlipidemia. Anthocyanins, which are natural antioxidants, have been reported to manage T2DM-related complications. However, the potential of anthocyanin-rich black wheat as a functional food for managing diabetes remains unexplored. <i>Aim</i>: This study aimed to investigate the effects of anthocyanin-rich black wheat on glucose metabolism, insulin sensitivity, lipid profile, oxidative stress, inflammation, and organ protection in high fat diet-streptozotocin (HFD-STZ) induced T2DM rats. <i>Methods</i>: T2DM was induced in rats using HFD-STZ. The rats were fed with either white wheat or anthocyanin-rich black wheat chapatti. Glucose metabolism, insulin sensitivity, lipid profile, antioxidant enzymes, inflammatory markers, and glucose transporters were assessed. Histopathological analysis of the liver, kidneys, and spleen was performed. <i>Results</i>: Compared to white wheat chapatti, black wheat chapatti exhibited higher α-amylase and α-glucosidase inhibitory activities. Black wheat chapatti consumption significantly reduced blood glucose and HbA1c levels, and improved insulin sensitivity, oral glucose tolerance, and insulin tolerance. Antioxidant enzyme (superoxide dismutase and catalase) activities were enhanced. Atherogenic dyslipidemia was attenuated, with improved high-density lipoprotein cholesterol levels. Inflammatory markers (TNF-α, IL-1β, leptin, resistin and cortisol) were reduced, while adiponectin (Acrp-30) levels increased. Black wheat chapatti activated adiponectin-AMPK and PI3K-AKT pathways, upregulating glucose transporters (GLUT-2 and GLUT-4). Histopathology revealed protective effects on the liver, kidneys, and spleen. <i>Conclusions</i>: Anthocyanin-rich black wheat chapatti ameliorates insulin resistance and associated complications in HFD-STZ-induced T2DM rats. It modulates key signaling pathways and glucose transporters, demonstrating its potential as a functional food for managing T2DM and its complications.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enrichment of polymethoxyflavones from citrus fruits using an optimized enzyme/acid-catalyzed hybrid hydrolysis process and its influence on mice gut microbiota.","authors":"Meng Sun, Jianjia Liang, Yan Peng, Leilei Qin, Dongxu Ma, Xiaorong Cai, Lu Ran, Yueyi Wang, Huimin Wang, Changying Yang, Xiaowen Liu, Zhangshuang Deng","doi":"10.1039/d4fo03391d","DOIUrl":"https://doi.org/10.1039/d4fo03391d","url":null,"abstract":"<p><p>Citrus polymethoxyflavones (PMFs) have considerable medicinal, health-promoting, and commercial importance. To provide a stable and reliable source of PMFs, an efficient process of large-scale preparation is warranted. Here, an extraction model for enriching PMFs from citrus fruits was proposed using an enzyme/acid-catalyzed hybrid hydrolysis approach. This method was optimized using response surface methodology (RSM). Furthermore, this model was applied to ten citrus varieties to prepare PMF-rich extracts, and six main PMFs were qualitatively and quantitatively analyzed using UPLC-ESI-MS/MS. Among the ten investigated citrus extracts, nobiletin was the most predominant PMF. The total yields of the six PMFs were ranked as <i>C. unshiu</i> > <i>C. reticulata</i> > <i>C. sinensis</i>, indicating that <i>C. unshiu</i> was the most suitable raw material for PMF preparation. Additionally, the PMF-rich extracts showed beneficial regulatory effects on gut microbiota, highlighting their potential health-promoting and therapeutic functions, which warrant further exploration.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition of linear and branched short-chain fatty acids in human milk and newborn feces: influence of perinatal and maternal factors.","authors":"Cristian Emmanuel Luna-Guzmán, Imelda Cecilia Zarzoza-Mendoza, Emmanuel Cervantes-Monroy, Judith Villa-Morales, Fairt Vladimir Carmona-Sierra, Jorge Maldonado-Hernández, Israel Domínguez-Calderón, Maricela Rodriguez-Cruz","doi":"10.1039/d4fo03568b","DOIUrl":"https://doi.org/10.1039/d4fo03568b","url":null,"abstract":"<p><p>This research aimed to analyze the percentage of short-chain fatty acids (SCFAs) in human milk (HM) and newborn feces and to explore potential associations with factors such as maternal nutrition, age, biological sex, delivery mode, diet, and the type of HM. Gas chromatography was used to measure the percentage of SCFAs in colostrum (<i>n</i> = 23), transitional HM (<i>n</i> = 23), and mature HM (<i>n</i> = 92) and feces of newborn (<i>n</i> = 36) at day 30 postpartum. Anthropometry was also evaluated in the mother and the infant. The results showed that acetic acid was the most abundant in HM. The percentage of butyric acid and isovaleric acid was higher (<i>p</i> < 0.05) in the feces of newborns whose mothers were overweight/obese or were male, respectively, compared to newborns whose mothers were of normal weight or were female. The percentage of valeric acid was higher in the feces of newborns whose mothers were over 30 years old and who were delivered by C-section, compared to newborns whose mothers were 30 years old or younger and who were delivered vaginally. Inadequate intake of proteins, carbohydrates, and fiber was associated (<i>p</i> < 0.05) with lower acetic acid and higher butyric acid, higher propionic acid and lower butyric acid, and higher isovaleric acid percentage, respectively, in mature HM. The percentage of acetic acid was higher (<i>p</i> < 0.01) and that of propionic acid, butyric acid, isobutyric acid, and isovaleric acid was lower (<i>p</i> < 0.01) in colostrum compared to mature HM. The intake of lipids was associated with the percentage of butyric acid (<i>β</i> = -0.32, <i>p</i> = 0.01), and the percentage of propionic acid (<i>β</i> = 0.43, <i>p</i> < 0.01) was associated with carbohydrate intake. Overall, this study concluded that factors such as maternal nutritional status, diet, age, biological sex, and delivery mode were related to the composition of specific SCFAs in mature HM and newborn feces. Additionally, the percentage of SCFAs gradually decreased from colostrum to mature HM.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Bifidobacterium bifidum</i> CCFM1359 alleviates intestinal motility disorders through the BDNF-TrkB pathway.","authors":"Linlin Wang, Liping Cao, Qiangqing Yu, Mengxia Liang, Zhichao Yang, Gang Wang, Jianxin Zhao, Wei Chen","doi":"10.1039/d4fo03710c","DOIUrl":"https://doi.org/10.1039/d4fo03710c","url":null,"abstract":"<p><p>Intestinal motility disorder is characterised by abnormal intestinal motility function, often resulting in symptoms such as diarrhoea and constipation. Probiotics are increasingly recognised as an effective treatment for gastrointestinal disorders, including intestinal motility disorders. In this study, we used senna extract to induce an animal model of intestinal dysfunction characterised by BDNF downregulation. By assessing relevant indicators of intestinal dyskinesia, we found that <i>Bifidobacterium bifidum</i> CCFM1359 effectively alleviated the dyskinesia. However, this alleviating effect was nullified when a TrkB receptor inhibitor was introduced, suggesting that <i>Bifidobacterium bifidum</i> CCFM1359 operates through the BDNF-TrkB pathway. Further analysis revealed that <i>Bifidobacterium bifidum</i> CCFM1359 likely exerts its beneficial effects by regulating intestinal microecology (increasing the relative abundance of <i>Bifidobacterium bifidum</i> and valeric acid content while decreasing <i>Faecalibacterium</i> and butyric acid content), reducing intestinal inflammation (upregulating the anti-inflammatory factor <i>IL-10</i> and downregulating pro-inflammatory factors <i>TNF-α</i> and <i>IL-1β</i>), and remodelling intestinal nerves (upregulating <i>S100β</i> and the excitatory neurotransmitter ACh, while downregulating the inhibitory neurotransmitter nNOS). This study provides a theoretical basis for using probiotics to alleviate intestinal motility disorders.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Melatonin as an inducer of arecoline and their coordinated roles in anti-oxidative activity and immune responses.","authors":"Xiaojian Yin, Yunxie Wei, Wei Song, He Zhang, Guoyin Liu, Yan Chen, Lan-Zhu Li, Raphael N Alolga, Gaoxiang Ma, Russel J Reiter, Jia Li, Haitao Shi","doi":"10.1039/d4fo90122c","DOIUrl":"https://doi.org/10.1039/d4fo90122c","url":null,"abstract":"<p><p>Correction for 'Melatonin as an inducer of arecoline and their coordinated roles in anti-oxidative activity and immune responses' by Xiaojian Yin <i>et al.</i>, <i>Food Funct.</i>, 2020, <b>11</b>, 8788-8799, https://doi.org/10.1039/D0FO01841D.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Bifidobacterium longum</i> subsp. <i>longum</i> relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation.","authors":"Chenyue Zhang, Linlin Wang, Xiaoming Liu, Gang Wang, Jianxin Zhao, Wei Chen","doi":"10.1039/d4fo04660a","DOIUrl":"https://doi.org/10.1039/d4fo04660a","url":null,"abstract":"<p><p><i>Bifidobacterium</i> species are known for their efficacy in alleviating constipation. This study aimed to compare the constipation-relieving effects of different <i>Bifidobacterium</i> species (<i>Bifidobacterium longum</i> subsp. <i>longum</i>, <i>Bifidobacterium bifidum</i>, <i>Bifidobacterium animalis</i>, <i>Bifidobacterium breve</i>, <i>Bifidobacterium longum</i> subsp. <i>infantis</i>, and <i>Bifidobacterium adolescentis</i>) and to explore the underlying mechanisms from both the bacterial and host perspectives. We evaluated six <i>Bifidobacterium</i> species for their physiological properties, including growth rate, oligosaccharide utilization, osmotic pressure resistance, cell adhesion, and bile acid dissociation capability. Mice with severe constipation induced by loperamide hydrochloride were treated with these bacteria at a density of 10⁹ CFU per mL for 17 days. Gastrointestinal indices such as fecal water content, time to first black stool defecation, and small intestine propulsion rate were measured to assess constipation relief. Microbiome and metabolome (bile acid and tryptophan) analyses were conducted to elucidate the differences in constipation relief among the species. Our results demonstrated that <i>Bifidobacterium longum</i> subsp. <i>longum</i> exhibited superior physiological traits, including rapid growth, extensive oligosaccharide utilization, and high bile salt dissociation capacity. Notably, only <i>Bifidobacterium longum</i> subsp. <i>longum</i> significantly ameliorated constipation symptoms in the mouse model. Furthermore, this strain markedly restored bile acid and short-chain fatty acid levels in the intestines of constipated mice and altered the composition of the intestinal microbiota. These findings suggest that the enhanced efficacy of <i>Bifidobacterium longum</i> subsp. <i>longum</i> in relieving constipation is associated with its ability to modulate intestinal physiology and microbiota structure and metabolism.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of sulforaphane bioavailability from a glucoraphanin-rich broccoli seed extract in a model of dynamic gastric digestion and absorption by Caco-2 cell monolayers.","authors":"Wei Zhu, Eleonora Cremonini, Angela F Mastaloudis, Alyson E Mitchell, Gail M Bornhorst, Patricia I Oteiza","doi":"10.1039/d4fo04561k","DOIUrl":"https://doi.org/10.1039/d4fo04561k","url":null,"abstract":"<p><p>Broccoli is recognized for its health benefits, attributed to the high concentrations of glucoraphanin (GR). GR must be hydrolyzed by myrosinase (Myr) to form the bioactive sulforaphane (SF). The primary challenge in delivering SF in the upper gastrointestinal (GI) tract- is improving hydrolysis of GR to SF. Here, we optimized the formulation and delivery methods to improve GR conversion and SF bioavailability. We investigated whether the combination of GR-rich broccoli seed extract powder (BSE[GR]) with Myr-rich mustard seed powder (MSP[Myr]), ± ascorbic acid (AA, a co-factor of Myr), delivered as free powder or encapsulated powder, can: (i) facilitate GR hydrolysis to SF during dynamic <i>in vitro</i> gastric digestion and static <i>in vitro</i> small intestinal digestion, and (ii) increase SF bioavailability in Caco-2 cell monolayers, a model of human intestinal epithelium. Addition of exogenous Myr increased the conversion of GR to SF in free powder during small intestinal digestion, but not during gastric digestion, where Myr activity was inhibited by the acidic environment. Capsule delivery of BSE[GR]/MSP[Myr] (w/w ratio 4 : 1) resulted in a 2.5-fold higher conversion efficiency compared to free powder delivery (72.1% compared to 29.3%, respectively). AA combined with MSP[Myr] further enhanced the conversion efficiency in small intestinal digestion and the bioavailability of SF in Caco-2 cell monolayers. Bioavailability of GR as SF, SF metabolites, and GR was 74.8% in Caco-2 cell monolayers following 30 min gastric digestion and 60 min small intestinal digestion. This study highlights strategies to optimize GR bioconversion in the upper GI tract leading to enhanced SF bioavailability.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of metaproteomics and DNA metabarcoding as tools to assess dietary intake in humans.","authors":"Brianna L Petrone, Alexandria Bartlett, Sharon Jiang, Abigail Korenek, Simina Vintila, Christine Tenekjian, William S Yancy, Lawrence A David, Manuel Kleiner","doi":"10.1039/d4fo02656j","DOIUrl":"10.1039/d4fo02656j","url":null,"abstract":"<p><p>Objective biomarkers of food intake are a sought-after goal in nutrition research. Most biomarker development to date has focused on metabolites detected in blood, urine, skin, or hair, but detection of consumed foods in stool has also been shown to be possible <i>via</i> DNA sequencing. An additional food macromolecule in stool that harbors sequence information is protein. However, the use of protein as an intake biomarker has only been explored to a very limited extent. Here, we evaluate and compare measurement of residual food-derived DNA and protein in stool as potential biomarkers of intake. We performed a pilot study of DNA sequencing-based metabarcoding and mass spectrometry-based metaproteomics in five individuals' stool sampled in short, longitudinal bursts accompanied by detailed diet records (<i>n</i> = 27 total samples). Dietary data provided by stool DNA, stool protein, and written diet record independently identified a strong within-person dietary signature, identified similar food taxa, and had significantly similar global structure in two of the three pairwise comparisons between measurement techniques (DNA-to-protein and DNA-to-diet record). Metaproteomics identified proteins including myosin, ovalbumin, and beta-lactoglobulin that differentiated food tissue types like beef from dairy and chicken from egg, distinctions that were not possible by DNA alone. Overall, our results lay the groundwork for development of targeted metaproteomic assays for dietary assessment and demonstrate that diverse molecular components of food can be leveraged to study food intake using stool samples.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of new lipid ingredients during pregnancy and lactation on rat offspring brain gene expression.","authors":"Valentina Origüela, Antonio Gázquez, María José López-Andreo, Pilar Bueno-Vargas, Mustafa Vurma, José M López-Pedrosa, Brian J Leyshon, Matthew Kuchan, Jia Pei Chan, Elvira Larqué","doi":"10.1039/d4fo04425h","DOIUrl":"https://doi.org/10.1039/d4fo04425h","url":null,"abstract":"<p><p>Maternal dietary fat intake during pregnancy and lactation may influence the bioavailability of essential lipophilic nutrients, such as docosahexaenoic acid (DHA), that are important for both the mother and her child's development. This study aimed to evaluate the effects of different maternal fat diets on fat absorption and pup brain development by analyzing gene expression. Rats were fed diets with different lipid matrices during pregnancy and lactation: diet A, mono and diglycerides (MDG) + soy lecithin phospholipids (PL); diet B, MDG + soy lecithin PL + milk-derived PL; and a control diet. All diets contained the same amount of DHA. We determined maternal dietary fat absorption, as well as the offspring fatty acid (FA) profile in both plasma and brain samples at birth and in pups at 14 days post-natal. In addition, microarray analysis was performed to characterize the pup brain gene expression. Maternal dietary fat and DHA apparent absorption was enhanced only with diet B. However, we observed higher plasma DHA and total FA concentrations in lactating pups from the experimental groups A and B compared to the control. Both brain DHA and total FA concentrations were also higher in fetuses and 14-day-old pups from group A with respect to the control, with diet B following the same trend. Offspring brain gene expression was affected by both diets A and B, with changes observed in synaptic and developmental processes in the fetuses, and the detoxification process in 14-day-old pups. Incorporating MDG and PL-rich lipid matrices into maternal diets during pregnancy and lactation may be highly beneficial for ensuring proper neurodevelopment of the fetus and newborn.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}