Association between ultra-processed foods and adiposity: findings from a Tehran lipid and glucose study.

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Food & Function Pub Date : 2025-07-22 DOI:10.1039/d4fo06072e
Mahdieh Golzarand, Nazanin Moslehi, Mohadeseh Aghasi, Parvin Mirmiran, Fereidoun Azizi
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引用次数: 0

Abstract

A few cohort studies have assessed the relationship between ultra-processed foods (UPFs) and obesity; however, there is a knowledge gap about adiposity. We designed the present cohort study to investigate the relationship between UPF consumption and adult adiposity. The adiposity indices considered in the present study included: waist circumference (WC), WC-to-height ratio (WHtR), Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) index, body roundness index (BRI), a body shape index (ABSI), and visceral adiposity index (VAI). This cohort study included 2734 adults from the Tehran Lipid and Glucose Study (TLGS). Five measurements were available at the baseline (2006-2008) and every three years until the end of follow-up (2018-2023). We applied the NOVA food classification to estimate our population's consumption of UPFs in servings per day. We used mixed linear regression to assess the association between the tertiles of UPFs as servings per day and changes in adiposity indices. The dose-response relationship between UPFs (serving per day) and outcomes was determined using a restricted cubic spline model. The mean age of participants was 39.8 years, and 54.1% were women. The median follow-up time was 11.9 years. The results of linear mixed models demonstrated a positive relationship between consumption of UPFs and weight (β = 0.17, P < 0.0001), body mass index (BMI) (β = 0.05, P = 0.002), CUN-BAE index (β = 0.08, P < 0.0001), WC (β = 0.16, P = 0.001), BRI (β = 0.02, P = 0.02), WHtR (β = 0.001, P = 0.005), and ABSI (β = 0.00006, P = 0.003) in the full model. There was no association between UPFs and the VAI (β = 0.01, P = 0.55). In the dose-response analysis, the association increased significantly after five servings per day. When we considered changes in each outcome per year, we found that the annual increases in weight by 0.12 kg, BMI by 0.04 kg m-2, WC by 0.12 cm, CUN-BAE index by 0.06 unit, BRI by 0.02 unit, and WHtR by 0.001 unit were greater in the third tertile of UPFs compared with the first tertile. Our results support the positive association between UPFs and adiposity indices.

超加工食品与肥胖之间的关系:来自德黑兰脂质和葡萄糖研究的发现。
一些队列研究评估了超加工食品(upf)与肥胖之间的关系;然而,关于肥胖的知识还存在差距。我们设计了本队列研究来调查UPF消费与成人肥胖之间的关系。本研究考虑的肥胖指标包括:腰围(WC)、腰高比(WHtR)、Clínica纳瓦拉大学身体肥胖估计器(cunbae)指数、体圆度指数(BRI)、体型指数(ABSI)和内脏肥胖指数(VAI)。这项队列研究包括来自德黑兰脂质和葡萄糖研究(TLGS)的2734名成年人。在基线(2006-2008年)和每三年(2018-2023年)进行五次测量。我们应用NOVA食品分类来估计我国人口每天食用upf的量。我们使用混合线性回归来评估每天upf的份数与肥胖指数变化之间的关系。upf(每天服用量)与结果之间的剂量-反应关系使用受限三次样条模型确定。参与者的平均年龄为39.8岁,其中54.1%为女性。中位随访时间为11.9年。线性混合模型结果表明,在全模型中,upf消耗与体重(β = 0.17, P < 0.0001)、体重指数(BMI) (β = 0.05, P = 0.002)、体重指数(β = 0.08, P < 0.0001)、腰围(β = 0.16, P = 0.001)、体重指数(β = 0.02, P = 0.02)、体重指数(β = 0.001, P = 0.005)和体重指数(β = 0.00006, P = 0.003)呈正相关。upf与VAI无相关性(β = 0.01, P = 0.55)。在剂量-反应分析中,这种关联在每天5次食用后显著增加。当我们考虑每年每个结果的变化时,我们发现upf的第三个分位数的体重增加了0.12 kg, BMI增加了0.04 kg -2, WC增加了0.12 cm, con - bae指数增加了0.06单位,BRI增加了0.02单位,WHtR增加了0.001单位,与第一分位数相比,第三个分位数的体重增加了0.001单位。我们的结果支持upf和肥胖指数之间的正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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