Accounts of Chemical Research最新文献

Cochlear Implantation: The Variation in Cochlear Height. 人工耳蜗植入：人工耳蜗高度的变化。

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-17 DOI: 10.1177/01455613221134860

Afrah Alshalan, Yassin Abdelsamad, Majed Assiri, Abdulrahman Alsanosi

{"title":"Cochlear Implantation: The Variation in Cochlear Height.","authors":"Afrah Alshalan, Yassin Abdelsamad, Majed Assiri, Abdulrahman Alsanosi","doi":"10.1177/01455613221134860","DOIUrl":"10.1177/01455613221134860","url":null,"abstract":"This study aimed to identify the association between different cochlear metrics, including the basal turn diameter (A-value), the basal turn width (B-value), and the height of the cochlea (H-value). We also reported an association between H-value and hearing outcomes with cochlear implants (CI). This is a retrospective study that included all patients who underwent CI procedures between 2012 and 2018 at a tertiary center and have; preoperative high-resolution computed tomography (CT), normal cochlea, postoperative follow-up duration of at least 2 years, scores of the category auditory performance II (CAP-II), and speech intelligibility rating (SIR) scales. A total of 65 ears implanted with CI in 46 patients (24 boys and 20 girls; mean age of 7 (±10) years) fulfilled the inclusion criteria. We found significant positive correlations between A vs B, A vs H, and B vs H (P-value = 0.008, 0.018, and 0.0039, respectively). We also found a significant positive relationship between A, B, and H values and cochlear duct length (CDL) (P-value < 0.0001, 0.008, and 0.018, respectively). Finally, the H-value was significantly correlated with the SIR (P-value = 0.027). However, its correlation with the CAP score was not statistically significant (P-value = 0.62). Cochlear height significantly correlated with CDL and the other cochlear parameters. The variation in cochlear height can also affect speech outcomes in patients undergoing CI. Therefore, the H-value together with the other cochlear metrics should be adequately assessed preoperatively in CI patients.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"501-507"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Application of Submental Island Flaps in Repair and Reconstruction of Head and Neck Tumors: Retrospective Review of a Single-Center Experience. 门下岛状皮瓣在头颈部肿瘤修复和重建中的临床应用：单中心经验的回顾性总结。

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-25 DOI: 10.1177/01455613221136671

Pingdong Li, Haiyang Li, Shuo Ding, Jing Zhou, Xiaohong Chen, Jugao Fang, Zhigang Huang

{"title":"Clinical Application of Submental Island Flaps in Repair and Reconstruction of Head and Neck Tumors: Retrospective Review of a Single-Center Experience.","authors":"Pingdong Li, Haiyang Li, Shuo Ding, Jing Zhou, Xiaohong Chen, Jugao Fang, Zhigang Huang","doi":"10.1177/01455613221136671","DOIUrl":"10.1177/01455613221136671","url":null,"abstract":"BackgroundBased on our cadaveric study findings and the clinical practice, the improved submental island flaps (SIF) used on a case series to reconstruct postoperative defects were reviewed and analyzed, to summarize the technical operation of flap cutting and propose the anterograde anatomical technique of point-line-plane alignment.MethodsThe cadaveric study was carried out first and a case series of about 23 head and neck tumor cases that underwent one-stage SIF repair were reviewed and followed up. The intraoperative anatomy, the technical essentials for vascular pedicle protection and submandibular lymph nodes treatment, and the rational design of flap incisions were analyzed and described.ResultsMost patients (21/23, 91.3%), comprising 19 males and 4 females with a mean age of 59 years, recovered completely from the application of SIFs in the repair and reconstruction of head and neck tumors; Only 2 patients experienced partial flap necrosis, which resolved following a local dressing change. The predominant donor site complication was transitory paralysis of the mandibular marginal branch of the facial nerve (MMBFN) (3/23, 13.0%), and the donor site was closed in one stage without skin grafting. The hair growth on skin flaps was not an issue for male patients requiring postoperative radiotherapy.ConclusionsSIF is a viable choice for correcting abnormalities of the head and neck tumor with the convenience of flap cutting and the effectiveness of the repair. In addition, it permits simultaneous treatment of the lymph nodes in the region I.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP529-NP539"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Results of a Multimodal Treatment Regimen in Patients With Auricular Keloids. 耳廓瘢痕患者多模式治疗方案的长期效果

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-31 DOI: 10.1177/01455613221133202

Daniel Häussler, Stefanie Hüttemann, Jörn Brom, Nicole Rotter, Haneen Sadick

{"title":"Long-Term Results of a Multimodal Treatment Regimen in Patients With Auricular Keloids.","authors":"Daniel Häussler, Stefanie Hüttemann, Jörn Brom, Nicole Rotter, Haneen Sadick","doi":"10.1177/01455613221133202","DOIUrl":"10.1177/01455613221133202","url":null,"abstract":"Objectives: The treatment of auricular keloids is challenging, as they tend to recur; further, the treatment may impact quality of life and implies cosmetic and functional impairment for each patient. There is no standardized therapeutic concept established, and the literature is lacking long-term results of available treatment modalities. Methods: Patients suffering from auricular keloids were included in the study. All patients had undergone surgical resection, intralesional injection of triamcinolone acetonide (TAC), and the application of an individual pressure splint. Quality of life (QoL) was assessed using the keloid intervention benefit inventory 21 (KIBI-21). Further analysis was carried out for patients without (group 1) and with (group 2) recurrence of the keloid. Results: In total, 50 keloids with a mean follow-up period of 59 months (range 6-137 months) could be analyzed. In nine cases (18%), a keloid recurrence was found during the observation period. The assessment of QoL differed significantly between study groups at P = 0.04, as well as for the subcategories General Health (GH) and Physical Health (PH). No differences were found for the categories Social Impact (SI) and Self-Esteem (SE). Conclusions: The multimodal subsequent treatment regimen consisting of surgical resection, intralesional TAC injection, and the application of an individual magnetic pressure splint shows good results concerning long-term recurrence rates. The treatment method shows positive effects on the QoL, especially in the measured categories GH and PH.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"486-492"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40446319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restless legs syndrome and headache cause sleepiness and consequent poor school performance: a community-based study from Turkey. 不宁腿综合征和头痛导致嗜睡，进而导致学习成绩不佳：一项基于土耳其社区的研究。

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2021-06-21 DOI: 10.23736/S2724-5276.21.06303-5

Ayşegül Erdoğan, Deniz Tuncel, Sedat Işikay, Ramazan A Okyay

{"title":"Restless legs syndrome and headache cause sleepiness and consequent poor school performance: a community-based study from Turkey.","authors":"Ayşegül Erdoğan, Deniz Tuncel, Sedat Işikay, Ramazan A Okyay","doi":"10.23736/S2724-5276.21.06303-5","DOIUrl":"10.23736/S2724-5276.21.06303-5","url":null,"abstract":"Background: Disturbance of sleep habits leads to excessive daytime sleepiness (EDS), which may affect learning abilities and consequently academic performance. Therefore, the main aim of current paper was to determine the prevalence of headache and Restless legs syndrome (RLS) in school-aged adolescents and to evaluate the type of headache in adolescents, with a secondary aim to determine the effect of daytime sleepiness on academic success.Methods: This cross-sectional study was conducted on adolescents aged between 15 and 19 years of age, who were in high school education in the 2016-2017 academic years in Kahramanmaraş province. A comprehensive interview form including questions on demographic data, RLS diagnostic criteria, headache, and Epworth Sleepiness Scale (ESS) was applied to a total of 4151 students.Results: RLS was found in 3.2% of the participants in all age groups. The mean ESS scores in adolescents with RLS were significantly higher than in those without RLS. Headache was reported by 46.9% of the adolescents in the study, with a frequency of TTH type headache of 17.7% and migraine frequency of 5.2%. RLS frequency was determined to be significantly higher in adolescents with headache and migraine. The academic success rate was significantly lower in those with higher ESS scores.Conclusions: Migraine and RLS often coexist as comorbid conditions. EDS is an important factor affecting academic success in children. Headache and RLS should not be forgotten, among other reasons for increased daytime sleepiness and its etiology.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"314-319"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39252949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of cartilage and temporalis fascia grafts in type 1 tympanoplasty: A meta-analysis. 1型鼓室成形术中软骨与颞筋膜移植的比较：荟萃分析

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-27 DOI: 10.1177/01455613221137122

Kai Chen, Rui Zhao

{"title":"Comparison of cartilage and temporalis fascia grafts in type 1 tympanoplasty: A meta-analysis.","authors":"Kai Chen, Rui Zhao","doi":"10.1177/01455613221137122","DOIUrl":"10.1177/01455613221137122","url":null,"abstract":"ObjectiveTo systematically review the results of type 1 tympanoplasties with temporalis fascia (TF) vs cartilage grafts in patients with chronic otitis media.MethodsEligible studies were identified from PubMed, Ovid, and EMBASE databases prior to November 2021. We analyzed the pure tone audiometry (PTA) and air-bone gap (ABG) data as continuous variables, and the success rate was analyzed as a dichotomous variable.ResultsForty-four studies, including 4582 patients, were eligible. The cartilage graft overall morphologic success rate was higher than that of the TF grafts (P < .001). In the palisade (P < .004) and island grafts (P < .001) subgroups, the analysis was significantly different. However, there was no significant difference in the inlay butterfly grafts subgroup. For hearing outcomes, the analysis revealed that TF grafts had a smaller mean post-operative ABG (P = .009). However, the subgroup analysis showed no significant difference in the mean post-operative ABG. For PTA, there was no significant difference in hearing improvement. However, the palisade cartilage graft subgroup resulted in a better hearing outcome than the TF graft subgroup in terms of the mean post-operative PTA (P = .007). There was no significant difference in the functional success rate or mean ABG gain.ConclusionCartilage grafts have a better success rate than TF grafts in tympanoplasty. Both cartilage and TF tympanoplasty provided similar improvements in hearing outcome, while TF grafts generated a better outcome in post-operative ABG and palisade cartilage grafts in post-operative PTA. This may be related to the biological characteristics of the grafts. Further thorough studies need to be conducted.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP476-NP489"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40428086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Cause of Hearing Loss: Incudal Osteoma. 听力损失的不寻常原因：内侧骨瘤。

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-11 DOI: 10.1177/01455613221130887

Elif Gozgec, Hayri Ogul, Muhammed S Sakat

引用次数: 0

Measuring the Impact of a Delay in Care on Pediatric Otolaryngologic Surgery Completion. 衡量医疗延误对小儿耳鼻喉科手术完成率的影响。

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-14 DOI: 10.1177/01455613221134428

Geethanjeli N Mahendran, Ching Siong Tey, Mary Frances Musso, Grace Shebha Anand, Jeffrey Larson, Mitesh Mehta, Lara Reichert, Kara Prickett, Nikhila Pinnapureddy Raol

{"title":"Measuring the Impact of a Delay in Care on Pediatric Otolaryngologic Surgery Completion.","authors":"Geethanjeli N Mahendran, Ching Siong Tey, Mary Frances Musso, Grace Shebha Anand, Jeffrey Larson, Mitesh Mehta, Lara Reichert, Kara Prickett, Nikhila Pinnapureddy Raol","doi":"10.1177/01455613221134428","DOIUrl":"10.1177/01455613221134428","url":null,"abstract":"Objective: To determine if postponement of elective pediatric otorhinolaryngology surgeries results in a change in overall healthcare utilization and if there is any commensurate impact on disease progression. Methods: We identified patients ≤18 years of age whose surgeries were postponed at the onset of the COVID-19 pandemic-related shutdown. We then tracked patients' rate of and patterns of rescheduling surgery. Surveys were also sent to caregivers to better characterize his/her decision regarding moving forward with his/her child's surgery during COVID-19. Results: A total of 1915 pediatric patients had elective surgeries canceled, of which 992 (51.8%) were rescheduled within 4 months. No difference in rates of rescheduling was identified based on race or ethnicity. Patients who were scheduled for tonsillectomies and/or adenoidectomies were 1.22 times more likely to reschedule compared to those patients with other planned procedures (CI: 1.02-1.46). A total of 95 caregivers at two hospitals completed surveys: 44 (47.4%) rescheduled their child's surgery. Most caregivers who rescheduled were concerned their child's disease could impact their future (n = 14, 32%). Conclusions: Just over half of patients who had pediatric otolaryngologic surgery canceled during a period of social distancing went on to have surgery within a 4-month timeframe. This reflects the dependence of pediatric otolaryngologic surgery on environmental exposures and may represent a potential target for prevention and management of some pediatric otolaryngology diseases.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP558-NP564"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33512690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database. 不同组织学亚型口咽鳞癌的生存期比较：基于 SEER 数据库的倾向匹配评分分析。

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-11-01 DOI: 10.1177/01455613221136360

Tao Li, Yi Wang, Xianwang Xiang, Chuanjun Chen

{"title":"Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database.","authors":"Tao Li, Yi Wang, Xianwang Xiang, Chuanjun Chen","doi":"10.1177/01455613221136360","DOIUrl":"10.1177/01455613221136360","url":null,"abstract":"ObjectiveThe purpose of this study was to analyze the difference of survival rates in paitents with oropharyngeal keratinizing squamous cell carcinoma (KSCC), nonkeratinizing squamous cell carcinoma (NKSCC), basaloid squamous cell carcinoma (BSCC), and papillary squamous cell carcinoma (PSCC).Materials and methodsPatients diagnosed with oropharyngeal squamous cell carcinoma between 2004 and 2015 were collected from the SEER database. Cox proportional hazards models and Kaplan-Meier curves were used for survival analysis. Propensity score matching (PSM) was performed to adjust for the effect of confounding variables. Due to the small sample size of PSCC, this study did not perform PSM between it and other subtypes.ResultsThe 5-year cancer-specific survival (CSS) rate of PSCC was higher than that of KSCC, NKSCC, and BSCC (0.627 vs. 0.812 vs. 0.789 vs. 0.875, P < 0.05); And the CSS rate of KSCC was lower than that of other subtypes both before and after PSM. In addition, the 5-year and 10-year CSS rates of BSCC were not different from NKSCC (P > 0.05), but not as good as NKSCC in the long term (P = 0.028). After PSM, the 5-year, 10-year, and long-term prognosis of BSCC were significantly worse than those of NKSCC (P < 0.001).ConclusionThe 5-year CSS of PSCC was better than the other three subtypes. The short-term prognosis of BSCC was not significantly different from NKSCC, but the long-term survival was lower than that of NKSCC, and the difference was more obvious after PSM. Meanwhile, the prognosis of KSCC was worst.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP518-NP528"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overmedialization of Thyroplasty Implants and the Role for Anterior-Posterior Laryngeal Compression as a Diagnostic Tool. 甲状腺成形术植入物过度内收和喉前后压迫作为诊断工具的作用。

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-11-05 DOI: 10.1177/01455613221136676

Arnav A Shah, Keonho A Kong, Heather A Yeakel, Aaron J Jaworek, Robert T Sataloff

引用次数: 0

Development and Validation of a Clinical Prediction Model to Diagnose Sinonasal Inverted Papilloma Based on Computed Tomography Features and Clinical Characteristics. 基于计算机断层扫描特征和临床特征诊断鼻窦倒置乳头状瘤的临床预测模型的开发与验证

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-20 DOI: 10.1177/01455613221134421

Zengxiao Zhang, Longgang Yu, Jiaxin Jiang, Lin Wang, Shizhe Zhou, Dapeng Hao, Yan Jiang

{"title":"Development and Validation of a Clinical Prediction Model to Diagnose Sinonasal Inverted Papilloma Based on Computed Tomography Features and Clinical Characteristics.","authors":"Zengxiao Zhang, Longgang Yu, Jiaxin Jiang, Lin Wang, Shizhe Zhou, Dapeng Hao, Yan Jiang","doi":"10.1177/01455613221134421","DOIUrl":"10.1177/01455613221134421","url":null,"abstract":"Objectives: Sinonasal inverted papilloma (SNIP) is one of the most common benign tumors of the nasal cavity and sinuses and is at risk for recurrence and malignant transformation. It is crucial to precisely predict SNIP before surgery to determine the optimal surgical technique and prevent SNIP recurrence. This study aimed to evaluate the diagnostic value of computed tomography (CT) features and SNIP clinical characteristics and to develop and validate a clinically effective nomogram. Methods: Here, 267 patients with SNIP and 273 with unilateral chronic rhinosinusitis with/without nasal polyps were included. Patient's demographic and clinical characteristics (i.e., gender, age, nasal symptoms, history of sinus surgery, smoking, and alcohol dependence) and CT features (i.e., lobulated/wavy edge, air sign, focal hyperostosis, diffuse hyperostosis, focal osseous erosion, and CT values) were recorded. Independent risk factors were screened using logistic regression analysis. A nomogram model was developed and validated. Results: Logistic regression analysis showed that age, facial pain/headache, history of sinus surgery, lobulated/wavy edge, air sign, focal hyperostosis, focal osseous erosion, and CT values were independent predictors of SNIP. A nomogram comprising these 8 independent risk factors was established. The area under the curve (AUC) for the training set was .960 (95% CI, .942-.978) and the AUC for the validation set was .951 (95% CI, .929-.971). Conclusion: The obtained results suggested that the nomogram based on age, facial pain/headache symptoms, history of sinus surgery, and CT characteristics had an excellent diagnostic value for SNIP.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP540-NP549"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40560805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0