Accounts of Chemical Research最新文献

{"title":"The Moderating Roles of Resilience and Coping Strategy on Well-Being of Victimized Forensic Workers.","authors":"Caroline Rou, Marija Janković, Stefan Bogaerts","doi":"10.1177/0306624X221124834","DOIUrl":"10.1177/0306624X221124834","url":null,"abstract":"<p><p>Previous research on workplace victimization has often disregarded forensic psychiatric populations and not yet been extended to the coronavirus pandemic. The present study expected the isolation of the government-issued lockdown to increase aggressive behavior in forensic patients, ultimately decreasing the general well-being of victimized forensic workers. Possible buffering protective factors (resilience and active coping) and enhancing risk factors (avoidant coping and passive coping) were investigated with the intention of optimizing the general well-being of at-risk forensic workers. The valid sample (<i>N</i> = 311) consisted of Dutch and Belgian forensic workers (74.6% females) with at least 9 hours of weekly patient contact, and with a mean age of 37.99 (<i>SD</i> = 12.20). Participants reported the number of violent incidents in the past 2 months, as well as completed a questionnaire battery including measures of well-being, resilience, and coping strategies. A significant increase of victimization during the lockdown compared to after it was lifted was found, however, the study did not find evidence to support that this negatively influenced the worker's general well-being. Active coping was found to be a significant moderator and protective factor for the general well-being of victimized forensic workers. In contrast, resilience, avoidant and passive coping were not significant moderators in this association. The present study has valuable clinical implications that could lead to preparatory and preventative measures for forensic workers at risk of being victimized. Future research may investigate constructs such as life satisfaction and post-traumatic growth, as well as be broadened into prison populations.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"23-42"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40387047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Fearless\" Revisited: How This Peer-to-Peer Self-Help Group for Sex Offense Registrants and Their Families Continued to Operate during a Global Pandemic.","authors":"Lisa L Sample, Brooke N Cooley, Julie D Garman","doi":"10.1177/0306624X221132217","DOIUrl":"10.1177/0306624X221132217","url":null,"abstract":"<p><p>Among the challenges of the COVID-19 pandemic, peer-to-peer support groups sought virtual environments to bring individuals together. Building upon previous research of Fearless, a peer-to-peer support group for registered individuals, this study examines how changes in the format from in person to virtual impacted the group's ability to provide social support to members. A snowball sampling technique was used to identify 25 members of Fearless who regularly attended the group's virtual monthly meetings during the COVID social restrictions. Using thematic narrative analysis, researchers found that the virtual format offered both positive and negative changes for members of the group. Although participants note various challenges of virtual meetings, like concerns for privacy, online meetings still provided opportunities for members to continue identity work, which is critical for continued prosocial behavior.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"62-78"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40663505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis Consumption Among Adults Aged 55-65 in Canada, 2018-2021.","authors":"Elle Wadsworth, Nick Cristiano, Robert Gabrys, Justine Renard, David Hammond","doi":"10.1177/00220426231190022","DOIUrl":"10.1177/00220426231190022","url":null,"abstract":"<p><p>Cannabis consumption among aging adults in Canada is increasing. The aims of the study were to examine cannabis consumption patterns before and after non-medical cannabis legalization and assess whether these patterns differ between men and women. Data were analyzed from Canadian respondents in a repeat cross-sectional survey conducted in 2018-2021. Analyses were conducted among adults aged 55-65 (<i>n</i> = 18,177) who had consumed cannabis in the past 12-month (<i>n</i> = 4119). Past 12-month cannabis consumption significantly increased among 55-65-year-olds from 2018 (19.3%) to the first-year post-legalization in 2019 (24.5%; <i>p</i> < .001), but remained stable thereafter (24.3%, and 25.6% in 2020 and 2021). More men reported past 12-month consumption than women (28.4% vs. 21.4%; <i>p</i> < .001). A substantial number of cannabis consumers consumed to manage a physical or mental health condition. Targeted messaging might be beneficial for this age group, including possible interactions with other medications. This research may be helpful for informing age-adapted cannabis education.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"33-49"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47902673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Stereotypes and Perceptions of Stranger Violence: Attributions of Blame and Motivation.","authors":"Amber Phillips, Melissa S de Roos","doi":"10.1177/0306624X221124849","DOIUrl":"10.1177/0306624X221124849","url":null,"abstract":"<p><p>Violence is a harmful, complex and gendered act that impacts individuals and communities financially, physically, socially and psychologically. Many studies have investigated how and why gender impacts perceptions of intimate partner violence (IPV), but little research has investigated its effect on stranger violence, despite being publicly perceived as causing greater fear and harm. Th is study examines the effects of gender attitudes and stereotypes on perceptions of stranger violence, specifically attributions of blame, affective response, alleged motivations and attitudes regarding the acceptability of violence (in general). Data was collected from 265 United Kingdom (UK) adults using an online survey posted on Amazon's Mechanical Turk (MTurk). Results indicate that like IPV, gender affects perceptions of stranger violence. Male and female perpetrators of stranger violence are perceived differently, and gender differences are evident between male and female participants. Practical implications of the findings are discussed.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"43-61"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33501656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overrepresentation of Young Indigenous Offenders: Differences in Criminogenic Risk/Needs and Implications for Practice.","authors":"Kristie Dellar, Lynne Roberts, Jonathan Bullen, Kristy Downe, Robert Kane","doi":"10.1177/0306624X221113525","DOIUrl":"10.1177/0306624X221113525","url":null,"abstract":"<p><p>Indigenous youth are overrepresented in the Australian criminal justice system, yet little is known about how they differ from non-Indigenous youth in terms of criminogenic risk and need profiles in relation to reoffending. The aim of the study was to examine the differences between Indigenous and non-Indigenous youth in terms of criminogenic risk and need profiles. This paper expands on findings of our previous study. and present the results of two analyses. The first is a comparative analysis of the differences in criminogenic risk and need factors in a sample of 4,653 youth. Results raise questions about how Indigenous and non-Indigenous youth differ on type of criminogenic needs and how risk/needs are defined in an Indigenous context. The second analysis examines the predictive validity of a shortened version of the YLS/CMI in a subsample of 921 youth. Results show that a specific combination of five items for Indigenous youth corresponds to an improvement in AUC scores from <i>c.</i> = 0.65 for the full version to <i>c.</i> = 0.73. For non-Indigenous youth, the selected set of five items corresponds to an improvement in AUC scores from <i>c.</i> = 0.66 for the full version of the YLS/CMI to <i>c.</i> = 0.73. Implications of these findings for research, policy, and reducing Indigenous overrepresentation are discussed.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"3-22"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of New Methods of Studying Catalyst and Materials Surfaces with Ambient Pressure Photoelectron Spectroscopy","authors":"Franklin Tao","doi":"10.1021/acs.accounts.4c00508","DOIUrl":"https://doi.org/10.1021/acs.accounts.4c00508","url":null,"abstract":"The surface of a catalyst is crucial for understanding the mechanisms of catalytic reactions at the molecular level and developing new catalysts with higher activity, selectivity, and durability. Ambient pressure X-ray photoelectron spectroscopy (AP-XPS) is a technique studying the surface of a sample in the gas phase, mainly identifying chemical identity, analyzing oxidation state, and measuring surface composition.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"24 1","pages":""},"PeriodicalIF":18.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do-Nothing Prebiotic Chemistry: Chemical Kinetics as a Window into Prebiotic Plausibility.","authors":"Skyla B White, Paul B Rimmer","doi":"10.1021/acs.accounts.4c00247","DOIUrl":"https://doi.org/10.1021/acs.accounts.4c00247","url":null,"abstract":"<p><p>ConspectusOrigin of Life research is a fast growing field of study with each year bringing new breakthroughs. Recent discoveries include novel syntheses of life's building blocks, mechanisms of activation and interaction between molecules, and newly identified environments that provide promising conditions for these syntheses and mechanisms. Even with these new findings, firmly grounded in rigorous laboratory experiments, researchers often find themselves uncertain about how to apply them. How can a bridge be built between the laboratory and the geochemical environment? A critical question to ask when seeking to apply new results in origins is: how can this chemistry occur without direct intervention from a chemist? We believe the first step toward answering this question lies in the determination of rate constants and the construction of chemical networks to describe prebiotic chemistry in geochemical environments.So far, our group has measured several rate constants relevant to different prebiotic reaction networks, starting with the synthetic pathways of the cyanosulfidic network. The reactions we explore often involve ultraviolet light-driven photochemistry, facilitated by our StarLab setup that accurately simulates the spectrum of the young Sun and other stars. Our latest work investigates environments with active photochemistry in the absence of cyanide. In this study, we measure the effective rate constant for the production of formate from the reduction of carbon species using sulfite within the context of early Martian waters. The underlying goal of the work done in our group is to predict the likelihood that certain geological conditions will result in a specific set of chemical products. These predictions can be combined with those we have made for the necessary astrophysical conditions in certain origins of life scenarios on extrasolar planets.In the near future we expect that a sufficient number of rate constants will be measured, by our group and others, to allow for aspects of prebiotic chemistry to be predicted using chemical kinetics models. Once these models have been benchmarked against experimental data, our next step will be applying them to natural environments that better mimic the conditions thought to have been present at the onset of life. Following this, we can test these models by comparing their predictions to additional experiments. After refinement, these models will be able to provide guidance on the optimal conditions for conducting laboratory experiments, while helping to minimize and characterize any interference from a chemist.This approach can provide valuable insights into what is possible within geochemical environments, where all chemistry is by necessity do-nothing chemistry.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":""},"PeriodicalIF":16.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Total Synthesis of Natural Products.","authors":"Lijun Chen, Peng Chen, Yanxing Jia","doi":"10.1021/acs.accounts.4c00654","DOIUrl":"10.1021/acs.accounts.4c00654","url":null,"abstract":"&lt;p&gt;&lt;p&gt;ConspectusCurrently, the frontier challenges in total synthesis pertain to increasing the synthetic efficiency and enabling the divergent synthesis of a number of natural products. Bioinspired synthesis has been well recognized as an effective approach to increasing synthetic efficiency. Especially, when bioinspired synthesis was applied at late-stage skeletal diversification to generate various natural products with distinct carbon skeletons, it held special promise for achieving both goals. In our laboratory, bioinspired synthesis has served as one of two long-standing principles for facilitating the efficient synthesis of natural products. In this Account, we summarize our endeavors and journeys in the bioinspired synthesis of natural products. We categorize our work into three parts based on the imitation of biosynthetic reactions and processes.(1) To mimic the key cyclization steps. Inspired by the biosynthetic process that formed the core skeleton, we developed new synthetic methods to enable the rapid and efficient construction of the core skeletons of the targeted molecules, ultimately leading to their concise total synthesis, for example, seven-step total synthesis of lamellarins D and H featuring three bioinspired oxidative coupling reactions, seven-step total synthesis of clavicipitic acid highlighted by a C-H activation/aminocyclization cascade reaction, eight-step total synthesis of phalarine via a bioinspired oxidative coupling, seven-step total synthesis of α-cyclopiazonic acid, and ten-step total synthesis of speradine C through a bioinspired cascade cyclization reaction initiated by the benzylic carbocation of indole. (2) To mimic the revised biosynthetic pathway proposed by us. In some cases, the proposed biosynthetic processes may be flawed, as they contradict some basic principles of chemistry. Thus, an alternative biosynthetic process must be proposed and investigated. We showcase the total synthesis of euphorikanin A through a bioinspired benzilic acid-type rearrangement and bipolarolides A and B via a bioinspired Prins reaction/ether formation cascade cyclization. (3) To mimic the skeletal diversification process. Nature usually synthesizes a multitude of products from a key common intermediate in a divergent manner. Biogenic skeletal diversification to generate various natural products with distinct carbon skeletons has also drawn our attention. Compared with single-target-oriented synthesis, skeletal-diversity-oriented synthesis of natural products remains underexplored due to its high synthetic challenges. We showcased the divergent total syntheses of ten &lt;i&gt;pallavicinia&lt;/i&gt; diterpenoids with three distinct skeletons and six &lt;i&gt;grayanane&lt;/i&gt; diterpenoids with three distinct skeletons, which were achieved with unprecedented ease and high efficiency by imitation of the proposed biogenic skeletal diversification process. These two successful projects can serve as inspiration for the application of the bioinspired skel","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"3524-3540"},"PeriodicalIF":16.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling Guest Diffusion by Local Dynamic Motion in Soft Porous Crystals to Separate Water Isotopologues and Similar Gases.","authors":"Yan Su, Jia-Jia Zheng, Ken-Ichi Otake, Nobuhiko Hosono, Susumu Kitagawa, Cheng Gu","doi":"10.1021/acs.accounts.4c00325","DOIUrl":"10.1021/acs.accounts.4c00325","url":null,"abstract":"&lt;p&gt;&lt;p&gt;ConspectusThe precise and effective separation of similar mixtures is one of the fundamental issues and essential tasks in chemical research. In the field of gas/vapor separation, the size difference among the molecular pairs/isomers of light hydrocarbons and aromatic compounds is generally 0.3-0.5 Å, and the boiling-point difference is generally 6-15 K. These are necessary industrial raw materials and have great separation demands. Still, their separation mainly relies on energy-intensive distillation technology. On the other hand, remarkably similar substances such as oxygen/argon and isotopologues usually exhibit size differences of only 0-0.07 Å and boiling-point differences of only 1-3 K. Although their industrial separation can be realized, their efficiency is considerably low. Therefore, effectively separating remarkably similar mixtures is crucial in fundamental chemistry and industry, but it remains a significant challenge. Porous coordination polymers (PCPs) or metal-organic frameworks (MOFs) are emerging materials platforms for designing adsorbents for separating similar mixtures. However, the reported PCPs did not work well for separating remarkably similar substances. The framework structures of the mainstream PCPs remain unchanged (rigid) or significantly change (globally flexible) upon adsorption. However, rigid and globally flexible PCPs find controlling the pore aperture in subangstrom precision challenging, a prerequisite for distinguishing remarkably similar substances. Thus, novel mechanisms and materials design principles are urgently needed to realize PCPs-based adsorptive separation of remarkably similar mixtures.To confront the obstacles in separating remarkably similar mixtures, our group started contributing to this field in 2017. We employed locally flexible PCPs as the materials designing platform, whose local motions of the side substituent groups potentially regulate the pore apertures to design and control the gas/vapor diffusion in PCPs. Specifically, we encoded dynamic flipping molecular motions into the diffusion-regulatory gate functionality. The ligands were designed by integrating carboxylic coordination groups with nonplanar fused-ring moieties, with the latter moieties exhibiting flipping motion around their equilibrium positions with small energy increases. Such local motions of ligands lead to the dynamic opening and blocking of PCP channels, thus termed flipping dynamic crystals (FDCs). FDCs feature distinctive temperature-responsive adsorption behaviors due to the competition of thermodynamics and kinetics under diffusion regulation, enabling differentiation of remarkably similar mixtures by each gate-admission temperature much higher than the boiling-point temperature of each component. Even when the molecular sizes are the same in the water isotopologue mixtures, FDCs can separate each isotopologue by amplifying their diffusion-rate differences. Finally, by combining the thermodynamic and kinetic","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"3455-3464"},"PeriodicalIF":16.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142550041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-in-One CO₂ Capture and Transformation: Lessons from Formylmethanofuran Dehydrogenases.","authors":"Olivier N Lemaire, Tristan Wagner","doi":"10.1021/acs.accounts.4c00623","DOIUrl":"10.1021/acs.accounts.4c00623","url":null,"abstract":"&lt;p&gt;&lt;p&gt;ConspectusCarbon-one-unit (C1) feedstocks are generally used in the chemical synthesis of organic molecules, such as solvents, drugs, polymers, and fuels. Contrary to the dangerous and polluting carbon monoxide mostly coming from fossil fuels, formate and formamide are attractive alternative feedstocks for chemical synthesis. As these are currently mainly obtained from the oil industry, novel synthetic routes have been developed based on the transformation of the greenhouse gas CO&lt;sub&gt;2&lt;/sub&gt;. Such developments are motivated by the urgent need for carbon chemical recycling, leading to a sustainable future. The inert nature of CO&lt;sub&gt;2&lt;/sub&gt; represents a challenge for chemists to activate and specifically convert the molecule through an affordable and efficient process. The chemical transformation could be inspired by biological CO&lt;sub&gt;2&lt;/sub&gt; activation, in which highly specialized enzymes perform atmospheric CO&lt;sub&gt;2&lt;/sub&gt; fixation through relatively abundant metal catalysts. In this Account, we describe and discuss the potential of one of the most efficient biological CO&lt;sub&gt;2&lt;/sub&gt;-converting systems: the formylmethanofuran dehydrogenase (abbreviated as FMD).FMDs are multienzymatic complexes found in archaea that capture CO&lt;sub&gt;2&lt;/sub&gt; as a formyl group branched on the amine moiety of the methanofuran (MFR) cofactor. This overall reaction leading to formyl-MFR production does not require ATP hydrolysis as compared to the CO&lt;sub&gt;2&lt;/sub&gt;-fixing microbes relying on the reductive Wood-Ljungdahl pathway, highlighting a different operative mode that saves cellular energy. FMD reaction represents the entry point in hydrogenotrophic methanogenesis (H&lt;sub&gt;2&lt;/sub&gt; and CO&lt;sub&gt;2&lt;/sub&gt; dependent or formate dependent) and operates in reverse in other methanogenic pathways and microbial metabolisms. Therefore, FMD is a key enzyme in the planetary carbon cycle. After decades of investigations, recent studies have provided a description of the FMD structure, reaction mechanism, and potential for the electroreduction of CO&lt;sub&gt;2&lt;/sub&gt;, to which our laboratory has been actively contributing.FMD is an \"all-in-one\" enzyme catalyzing a redox-active transformation coupled to a redox-neutral transformation at two very different metal cofactors where new C-H and C-N bonds are made. First, the principle of the overall reaction consisting of an exergonic CO&lt;sub&gt;2&lt;/sub&gt; reduction coupled with an endergonic formate condensation on MFR is resumed. Then, this Account exposes the molecular details of the active sites and provides an overview of each catalytic mechanism. It also describes the natural versatility of electron-delivery modules fueling CO&lt;sub&gt;2&lt;/sub&gt; reduction and extends it to the possibilities of using artificial systems such as electrodes.A perspective concludes on how the mechanistic of FMD could be applied to produce CO&lt;sub&gt;2&lt;/sub&gt;-based chemical intermediates to synthesize organic molecules. Indeed, through its biochemical properties, the enzyme opens","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"3512-3523"},"PeriodicalIF":16.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}