Long-Term Results of a Multimodal Treatment Regimen in Patients With Auricular Keloids.

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-31 DOI:10.1177/01455613221133202
Daniel Häussler, Stefanie Hüttemann, Jörn Brom, Nicole Rotter, Haneen Sadick
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Abstract

Objectives: The treatment of auricular keloids is challenging, as they tend to recur; further, the treatment may impact quality of life and implies cosmetic and functional impairment for each patient. There is no standardized therapeutic concept established, and the literature is lacking long-term results of available treatment modalities. Methods: Patients suffering from auricular keloids were included in the study. All patients had undergone surgical resection, intralesional injection of triamcinolone acetonide (TAC), and the application of an individual pressure splint. Quality of life (QoL) was assessed using the keloid intervention benefit inventory 21 (KIBI-21). Further analysis was carried out for patients without (group 1) and with (group 2) recurrence of the keloid. Results: In total, 50 keloids with a mean follow-up period of 59 months (range 6-137 months) could be analyzed. In nine cases (18%), a keloid recurrence was found during the observation period. The assessment of QoL differed significantly between study groups at P = 0.04, as well as for the subcategories General Health (GH) and Physical Health (PH). No differences were found for the categories Social Impact (SI) and Self-Esteem (SE). Conclusions: The multimodal subsequent treatment regimen consisting of surgical resection, intralesional TAC injection, and the application of an individual magnetic pressure splint shows good results concerning long-term recurrence rates. The treatment method shows positive effects on the QoL, especially in the measured categories GH and PH.

耳廓瘢痕患者多模式治疗方案的长期效果
目的:治疗耳廓瘢痕疙瘩具有挑战性,因为它们容易复发;此外,治疗可能会影响生活质量,并对每位患者的外观和功能造成损害。目前还没有统一的治疗理念,文献中也缺乏现有治疗方法的长期效果。治疗方法研究对象包括耳廓瘢痕疙瘩患者。所有患者均接受了手术切除、曲安奈德(TAC)鞘内注射和个性化压力夹板治疗。生活质量(QoL)通过瘢痕疙瘩干预效益清单21(KIBI-21)进行评估。对瘢痕疙瘩未复发(第一组)和复发(第二组)的患者进行了进一步分析。结果显示共分析了 50 例瘢痕疙瘩,平均随访时间为 59 个月(6-137 个月)。在观察期间,发现有 9 例(18%)瘢痕疙瘩复发。研究组之间的 QoL 评估差异显著(P = 0.04),一般健康(GH)和身体健康(PH)这两个子类别也存在显著差异。在社会影响(SI)和自尊(SE)这两个类别中没有发现差异。结论多模式后续治疗方案包括手术切除、椎管内注射 TAC 和应用个体磁压夹板,在长期复发率方面显示出良好的效果。该治疗方法对患者的生活质量有积极影响,尤其是在 GH 和 PH 两项指标上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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