Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-11-01 DOI:10.1177/01455613221136360

Tao Li, Yi Wang, Xianwang Xiang, Chuanjun Chen

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引用次数: 0

Abstract

ObjectiveThe purpose of this study was to analyze the difference of survival rates in paitents with oropharyngeal keratinizing squamous cell carcinoma (KSCC), nonkeratinizing squamous cell carcinoma (NKSCC), basaloid squamous cell carcinoma (BSCC), and papillary squamous cell carcinoma (PSCC).Materials and methodsPatients diagnosed with oropharyngeal squamous cell carcinoma between 2004 and 2015 were collected from the SEER database. Cox proportional hazards models and Kaplan-Meier curves were used for survival analysis. Propensity score matching (PSM) was performed to adjust for the effect of confounding variables. Due to the small sample size of PSCC, this study did not perform PSM between it and other subtypes.ResultsThe 5-year cancer-specific survival (CSS) rate of PSCC was higher than that of KSCC, NKSCC, and BSCC (0.627 vs. 0.812 vs. 0.789 vs. 0.875, P < 0.05); And the CSS rate of KSCC was lower than that of other subtypes both before and after PSM. In addition, the 5-year and 10-year CSS rates of BSCC were not different from NKSCC (P > 0.05), but not as good as NKSCC in the long term (P = 0.028). After PSM, the 5-year, 10-year, and long-term prognosis of BSCC were significantly worse than those of NKSCC (P < 0.001).ConclusionThe 5-year CSS of PSCC was better than the other three subtypes. The short-term prognosis of BSCC was not significantly different from NKSCC, but the long-term survival was lower than that of NKSCC, and the difference was more obvious after PSM. Meanwhile, the prognosis of KSCC was worst.

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不同组织学亚型口咽鳞癌的生存期比较：基于 SEER 数据库的倾向匹配评分分析。

研究目的本研究旨在分析口咽角化性鳞状细胞癌（KSCC）、非角化性鳞状细胞癌（NKSCC）、基底样鳞状细胞癌（BSCC）和乳头状鳞状细胞癌（PSCC）患者的生存率差异：从 SEER 数据库中收集 2004 年至 2015 年期间确诊为口咽鳞癌的患者。生存分析采用 Cox 比例危险模型和 Kaplan-Meier 曲线。进行倾向评分匹配（PSM）以调整混杂变量的影响。由于PSCC的样本量较小，本研究未对其与其他亚型进行倾向评分匹配：结果：PSCC的5年癌症特异性生存率（CSS）高于KSCC、NKSCC和BSCC（0.627 vs. 0.812 vs. 0.789 vs. 0.875，P<0.05）；而KSCC在PSM前后的CSS率均低于其他亚型。此外，BSCC的5年和10年CSS率与NKSCC无差异（P > 0.05），但远期不如NKSCC（P = 0.028）。PSM后，BSCC的5年、10年和长期预后均明显差于NKSCC（P < 0.001）：结论：PSCC 的 5 年 CSS 优于其他三个亚型。结论：PSCC 的 5 年 CSS 优于其他三个亚型，BSCC 的短期预后与 NKSCC 无明显差异，但长期生存率低于 NKSCC，且 PSM 后差异更为明显。同时，KSCC的预后最差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.