Accounts of Chemical Research最新文献

{"title":"Primary Cutaneous Cryptococcosis of Nose With Extensive Tissue Destruction: A Rare Case Report.","authors":"Yuriko Nishiyama-Fujita, Divya S Kondapi, G Robert Parkerson, Ya Xu","doi":"10.1177/01455613221126324","DOIUrl":"10.1177/01455613221126324","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP460-NP462"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40349941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reticular Chemistry within Crystalline Porous Gas Adsorbents and Membranes.","authors":"Weidong Fan, Yutong Wang, Zixi Kang, Daofeng Sun","doi":"10.1021/acs.accounts.5c00070","DOIUrl":"10.1021/acs.accounts.5c00070","url":null,"abstract":"<p><p>ConspectusAdsorptive and membrane separations are recognized as highly energy-efficient technologies, critically dependent on the properties of adsorbent and membrane materials. Crystalline porous materials (CPMs), such as metal-organic frameworks (MOFs), covalent organic frameworks (COFs), metal-organic cages (MOCs), and hydrogen-bonded organic frameworks (HOFs), have emerged as exceptional candidates for high-performance adsorbents and membranes due to their intrinsic structural tunability. Their orderly pore structure, high porosity, and large surface facilitate gas storage and separation processes. Furthermore, modifying the inner surface, controlling the pore size, and regulating the framework flexibility can significantly enhance CPMs' adsorption capacity and separation selectivity. Therefore, the precise structure regulation of CPMs is the key to optimizing gas separation and purification.Reticular chemistry is the use of strong chemical bonds to connect discrete molecular structures (molecules or molecular clusters) to create extended structures, such as CPMs. It allows precise atomic-level control and offers a method for regulating the structures of CPMs, enabling tailored pore environments that enhance selectivity for target separations. This approach is crucial to designing effective gas separation materials. For example, by functionalizing organic ligands, regulating metal ions, and modifying secondary building units, the pore size, porosity, and functionality of CPMs can be finely controlled while keeping the framework topology unchanged, thereby optimizing the gas separation performance.In this Account, we present an overview of our group's research efforts on optimizing gas separation by fine-tuning CPM adsorbents and membranes. Using reticular chemistry, we have developed strategies such as multiple cooperative regulation, adaptive pore control, pore environment engineering, preprocessed monomer interfacial polymerization, and precursor solution processing to create highly selective CPM adsorbents and membranes. Additionally, we elucidate the underlying mechanism of multiple hydrogen bonding and dipole-dipole interactions between CPMs and hydrocarbon molecules. By precise structural regulation, we further optimize the gas separation performance and broaden CPMs' applications. Finally, we discuss the challenges and future directions for CPM adsorbents and membranes, including material design, synthesis, stability, performance, and the structure-activity relationship. We also propose a membrane-adsorptive separation coupling technology as a potential solution for achieving high-purity gas separation. By utilizing CPM-based adsorbents and membranes, we aim to establish an energy-intensive and environmentally friendly pathway for the separation of low-carbon hydrocarbons, hydrogen, and natural gas, providing a sustainable alternative to conventional high-energy gas separation processes.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"1937-1950"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic finding of leiomyosarcoma in a neurofibromatosis patient.","authors":"Sola Han, Jong Seung Kim, Myung-Ja Chung","doi":"10.1177/01455613221127488","DOIUrl":"10.1177/01455613221127488","url":null,"abstract":"<p><p>A man with a history of neurofibromatosis presented to our hospital with a soft palate mass. Since the patient had neurofibromatosis, we diagnosed the mass as a neurofibroma and planned annual regular follow-up without any treatment. Five months later, the patient visited our emergency department because of uncontrolled epistaxis, and the mass was enlarged to the extent of the airway obstruction. Endoscopic resection was performed and the tumor was confirmed to be a leiomyosarcoma. The malignant potential of the new lesion in a neurofibromatosis patient should be actively evaluated and treated, if required.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"397-398"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33468595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater Palatine Canal: Computed Tomography-Based Anatomic Analysis And Clinical Significance for the Sinus and Skull Base Surgeon.","authors":"André Machado, Daniel Simmen, Bernhard Schuknecht, Hans Rudolf Briner","doi":"10.1177/01455613221111063","DOIUrl":"10.1177/01455613221111063","url":null,"abstract":"<p><p>ObjectiveOur aim is to describe the location and course of the greater palatine canal (GPC) by analyzing its relationship with anatomical landmarks that can be used during endoscopic sinus surgery. This information might help prevent injury to the neurovascular bundle.MethodsA retrospective evaluation of paranasal sinus CT scans of 100 consecutive random patients, 200 sides, was performed. Five measurements related to the course of the GPC were conducted, from cranial to caudal. The anatomical landmarks were the inferior bony border of the sphenopalatine foramen to the cranial entrance of the GPC, the distance from the most dorsal, and inferior bony insertion of the middle turbinate and the inferior turbinate bones to the anterior margin of the GPC. The angle between the horizontal palatine bone and the GPC, its length, and the prevalence of osteophytes in GPC was also assessed.ResultsThe mean distance of the inferior border of the sphenopalatine foramen to the cranial entrance of the GPC was 9.39 ± 1.72 mm. The mean distance of the dorsal insertion of the middle turbinate to the anterior margin of the GPC was 3.89 ± 0.93 mm. The distance of the dorsal insertion of the inferior turbinate to the anterior margin of the GPC was 3.16 ± 0.81 mm. The mean angle between the horizontal palatine bone and the GPC was 114.33 ± 10.92º and the mean length of the GPC was 30.23 ± 3.74 mm. None of the measurements showed a significant difference between the two sides.ConclusionsThe landmarks used are easy to locate and assess on CT scans. These findings may help to make dissection safer in pathologies related to the pterygopalatine fossa, lateral sphenoid sinus or adjacent skull base.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"424-430"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Treatment for Empty Nose Syndrome Using Autologous Dermal Fat: Evaluation of Symptomatic Improvement.","authors":"Yu Hosokawa, Takeshi Miyawaki, Kazuhiro Omura, Taisuke Akutsu, Ryohei Kimura, Tetsuo Ikezono, Nobuyoshi Otori","doi":"10.1177/01455613221130885","DOIUrl":"10.1177/01455613221130885","url":null,"abstract":"<p><p><b>Background:</b> Empty nose syndrome (ENS) is caused by nasal turbinate surgery. The standard treatment for ENS is an inferior meatus augmentation procedure (IMAP) in which autologous tissue such as auricular cartilage, rib cartilage, or artificial material is transplanted into the nasal cavity. However, some challenges like a very small auricular cartilage are associated with these autologous tissue types. Moreover, since using rib cartilage is a highly invasive technique, the scar on the chest from where the harvesting is done is easily visible, and the artificial material is susceptible to infection. We used autologous dermal fat (ADF) in IMAPs in our study for the following reasons: the quantity of ADF could be increased or reduced as needed, ADF is considered a safer option than rib cartilage because it is harvested from superficial tissue, it is superior in terms of cosmetic appearance to harvested rib cartilage, and it has a lower risk of infection than any artificial material.<b>Objective:</b> The purpose of our study was to investigate the efficacy and safety of IMAPs using ADF.<b>Methods:</b> We included nine patients with ENS who underwent an IMAP using ADF. The patients' backgrounds and responses to the Empty Nose Syndrome 6-Item Questionnaire (ENS6Q) were recorded. Changes in each item of the ENS6Q before and after surgery (up to 3 months) were analyzed.<b>Results:</b> The postoperative ENS6Q total score and parameters were significantly better than their preoperative counterparts. Nasal dryness improved slightly less than other symptoms. There were no complications.<b>Conclusions:</b> The IMAP using ADF was effective in improving ENS symptoms; however, some physiological functions were difficult to improve, and dryness persisted. Autologous dermal fat is larger than auricular cartilage, less invasive than rib cartilage, and has a lower risk of infection than artificial material.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP408-NP415"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40380250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Features of Lymphoepithelial-Like Carcinoma of the Salivary Glands.","authors":"Meng Zhang, Jingzhi Ye, Hongyi Li, Peikai Huang, Jun Chen, Fenghuang Lin, Mengqiang Xiao","doi":"10.1177/01455613221116330","DOIUrl":"10.1177/01455613221116330","url":null,"abstract":"<p><strong>Objective: </strong>Lymphoepithelial-like carcinoma of the salivary glands (LELCSG) is a rare tumour of unknown aetiology. No studies have reported the imaging features of primary LELCSG.</p><p><strong>Methods: </strong>The clinical information and imaging features of eight patients with LELCSG were reviewed. Computed tomography (n = 4 patients) and magnetic resonance imaging (n = 4 patients) features were analysed by two radiologists to identify the location, number, size, shape, boundary, signal intensity and enhancement of LELCSG.</p><p><strong>Results: </strong>The study included four women and four men, and the mean size of the tumours was 32.88 ± 3.41 mm (range, 27-38 mm). The tumours affected the parotid gland in six cases and the submandibular gland in two cases. The eight cases were evaluated by <b>radiologists</b>. All tumours were lobulated; three had clear edges and five had blurred edges. There was no necrosis in six tumours, while two tumours exhibited slight necrosis without bleeding. All eight tumours showed multiple nodular changes and extensive fusion. Four tumours with magnetic resonance imaging (MRI) were isointense or slightly hyperintense on T1-weighted imaging (T1WI) and obvious homogeneous enhancement on contrasted enhanced T1WI scan, while slightly hyperintense on T2-weighted imaging (T2WI). The other four lesions were <b>isodense</b> on computed tomography (CT) scan. The degree of enhancement varied among the eight tumours. The necrotic zones of the eight tumours did not exhibit any enhancement.</p><p><strong>Conclusions: </strong>LELCSG is a lobulated, multi-nodular tumour, with some fused nodules. LELCSG lesions showed isointensity or slight hyperintensity on T1WI MRI, slight hyperintensity on T2WI MRI and <b>isodense</b> on CT scan. Larger tumours may exhibit some necrosis, but the necrotic cysts were relatively rare. Uniform enhancement was observed in non-necrotic areas on enhanced CT and MRI scan. The multi-nodular feature may be valuable for diagnosis.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP426-NP431"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40505014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncocytic Papillary Cystadenoma of the Larynx: A Rare and Masquerading Entity.","authors":"Samuel Bosco, James Ding, Christopher Fundakowski","doi":"10.1177/01455613221124731","DOIUrl":"10.1177/01455613221124731","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"402-404"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Feng Xie,&nbsp;Hao Wang* and Jing Li*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 13","pages":"962–968 XXX-XXX"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.5c00217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Tonglin Yang,&nbsp;Yanwei Tang,&nbsp;Ying Wei*,&nbsp;Linghai Xie* and Wei Huang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 13","pages":"962–968 XXX-XXX"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.5c00180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Zi-Chao Wang,&nbsp; and ,&nbsp;Shi-Liang Shi*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 13","pages":"962–968 XXX-XXX"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.5c00304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}