ACS Infectious Diseases最新文献

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Navigating ESKAPE Pathogens: Considerations and Caveats for Animal Infection Models Development. ESKAPE 病原体导航:动物感染模型开发的考虑因素和注意事项。
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-12 Epub Date: 2024-06-12 DOI: 10.1021/acsinfecdis.4c00007
Haojie Yu, Yongchang Xu, Saber Imani, Zhuo Zhao, Saif Ullah, Qingjing Wang
{"title":"Navigating ESKAPE Pathogens: Considerations and Caveats for Animal Infection Models Development.","authors":"Haojie Yu, Yongchang Xu, Saber Imani, Zhuo Zhao, Saif Ullah, Qingjing Wang","doi":"10.1021/acsinfecdis.4c00007","DOIUrl":"10.1021/acsinfecdis.4c00007","url":null,"abstract":"<p><p>The misuse of antibiotics has led to the global spread of drug-resistant bacteria, especially multi-drug-resistant (MDR) ESKAPE pathogens (<i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> species). These opportunistic bacteria pose a significant threat, in particular within hospitals, where they cause nosocomial infections, leading to substantial morbidity and mortality. To comprehensively explore ESKAPE pathogenesis, virulence, host immune response, diagnostics, and therapeutics, researchers increasingly rely on necessitate suitable animal infection models. However, no single model can fully replicate all aspects of infectious diseases. Notably when studying opportunistic pathogens in immunocompetent hosts, rapid clearance by the host immune system can limit the expression of characteristic disease symptoms. In this study, we examine the critical role of animal infection models in understanding ESKAPE pathogens, addressing limitations and research gaps. We discuss applications and highlight key considerations for effective models. Thoughtful decisions on disease replication, parameter monitoring, and data collection are crucial for model reliability. By meticulously replicating human diseases and addressing limitations, researchers maximize the potential of animal infection models. This aids in targeted therapeutic development, bridges knowledge gaps, and helps combat MDR ESKAPE pathogens, safeguarding public health.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis. 真菌性角膜炎的病原学、流行病学、诊断和治疗。
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-12 Epub Date: 2024-06-07 DOI: 10.1021/acsinfecdis.4c00203
Amol Chhatrapati Bisen, Sachin Nashik Sanap, Sristi Agrawal, Arpon Biswas, Anjali Mishra, Sarvesh Kumar Verma, Vaishali Singh, Rabi Sankar Bhatta
{"title":"Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis.","authors":"Amol Chhatrapati Bisen, Sachin Nashik Sanap, Sristi Agrawal, Arpon Biswas, Anjali Mishra, Sarvesh Kumar Verma, Vaishali Singh, Rabi Sankar Bhatta","doi":"10.1021/acsinfecdis.4c00203","DOIUrl":"10.1021/acsinfecdis.4c00203","url":null,"abstract":"<p><p>Fungal keratitis (FK) is a severe ocular condition resulting from corneal infection that is prevalent in tropical countries, particularly in developing regions of Asia and Africa. Factors like corneal lens misuse, inappropriate steroid use, and diagnostic challenges have provoked the epidemic. FK causes significant vision impairment, scarring, and ocular deformities. Accurate pathological diagnosis is crucial for effective therapeutic intervention. Topical antifungal therapy with surface healing medications proves effective in preventing fungal-borne ulcers. Managing FK requires a comprehensive understanding of fungal pathogenesis, guiding formulation strategies and preventive measures to curb global ocular blindness. This review provides in-depth insights into FK, covering etiology, epidemiology, pathogenesis, therapeutic interventions, antifungal resistance, limitations, prevention, and future perspectives on ocular surface disease management.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotypic Landscape of Immune Cells in Sepsis: Insights from High-Dimensional Mass Cytometry. 败血症中免疫细胞的表型图谱:高维质量细胞计量学的启示
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-12 Epub Date: 2024-06-08 DOI: 10.1021/acsinfecdis.4c00066
Sehee Park, Haribalan Perumalsamy, Zayakhuu Gerelkhuu, Sneha Sunderraj, Yangsoon Lee, Tae Hyun Yoon
{"title":"Phenotypic Landscape of Immune Cells in Sepsis: Insights from High-Dimensional Mass Cytometry.","authors":"Sehee Park, Haribalan Perumalsamy, Zayakhuu Gerelkhuu, Sneha Sunderraj, Yangsoon Lee, Tae Hyun Yoon","doi":"10.1021/acsinfecdis.4c00066","DOIUrl":"10.1021/acsinfecdis.4c00066","url":null,"abstract":"<p><p>Understanding the sepsis-induced immunological response can be facilitated by identifying phenotypic changes in immune cells at the single-cell level. Mass cytometry, a novel multiparametric single-cell analysis technique, offers considerable benefits in characterizing sepsis-induced phenotypic changes in peripheral blood mononuclear cells. Here, we analyzed peripheral blood mononuclear cells from 20 sepsis patients and 10 healthy donors using mass cytometry and employing 23 markers. Both manual gating and automated clustering approaches (PhenoGraph) were used for cell identification, complemented by uniform manifold approximation and projection (UMAP) for dimensionality reduction and visualization. Our study revealed that patients with sepsis exhibited a unique immune cell profile, marked by an increased presence of monocytes, B cells, and dendritic cells, alongside a reduction in natural killer (NK) cells and CD4/CD8 T cells. Notably, significant changes in the distributions of monocytes and B and CD4 T cells were observed. Clustering with PhenoGraph unveiled the subsets of each cell type and identified elevated CCR6 expression in sepsis patients' monocyte subset (PG#5), while further PhenoGraph clustering on manually gated T and B cells discovered sepsis-specific CD4 T cell subsets (CCR4<sup>low</sup> CD20<sup>low</sup> CD38<sup>low</sup>) and B cell subsets (HLA-DR<sup>low</sup> CCR7<sup>low</sup> CCR6<sup>high</sup>), which could potentially serve as novel diagnostic markers for sepsis.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141292815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategic Single-Residue Substitution in the Antimicrobial Peptide Esc(1-21) Confers Activity against Staphylococcus aureus, Including Drug-Resistant and Biofilm Phenotype. 抗菌肽 Esc(1-21) 的策略性单残基置换赋予其对抗金黄色葡萄球菌的活性,包括耐药性和生物膜表型。
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-12 Epub Date: 2024-06-07 DOI: 10.1021/acsinfecdis.4c00130
Maria Rosa Loffredo, Bruno Casciaro, Rosa Bellavita, Cassandra Troiano, Diego Brancaccio, Floriana Cappiello, Francesco Merlino, Stefania Galdiero, Giancarlo Fabrizi, Paolo Grieco, Lorenzo Stella, Alfonso Carotenuto, Maria Luisa Mangoni
{"title":"Strategic Single-Residue Substitution in the Antimicrobial Peptide Esc(1-21) Confers Activity against <i>Staphylococcus aureus</i>, Including Drug-Resistant and Biofilm Phenotype.","authors":"Maria Rosa Loffredo, Bruno Casciaro, Rosa Bellavita, Cassandra Troiano, Diego Brancaccio, Floriana Cappiello, Francesco Merlino, Stefania Galdiero, Giancarlo Fabrizi, Paolo Grieco, Lorenzo Stella, Alfonso Carotenuto, Maria Luisa Mangoni","doi":"10.1021/acsinfecdis.4c00130","DOIUrl":"10.1021/acsinfecdis.4c00130","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i>, a bacterium resistant to multiple drugs, is a significant cause of illness and death worldwide. Antimicrobial peptides (AMPs) provide an excellent potential strategy to cope with this threat. Recently, we characterized a derivative of the frog-skin AMP esculentin-1a, Esc(1-21) (<b>1</b>) that is endowed with potent activity against Gram-negative bacteria but poor efficacy against Gram-positive strains. In this study, three analogues of peptide <b>1</b> were designed by replacing Gly<sup>8</sup> with α-aminoisobutyric acid (Aib), Pro, and dPro (<b>2</b>-<b>4</b>, respectively). The single substitution Gly<sup>8</sup> → Aib<sup>8</sup> in peptide <b>2</b> makes it active against the planktonic form of Gram-positive bacterial strains, especially <i>Staphylococcus aureus</i>, including multidrug-resistant clinical isolates, with an improved biostability without resulting in cytotoxicity to mammalian cells. Moreover, peptide <b>2</b> showed a higher antibiofilm activity than peptide <b>1</b> against both reference and clinical isolates of <i>S</i>. <i>aureus</i>. Peptide <b>2</b> was also able to induce rapid bacterial killing, suggesting a membrane-perturbing mechanism of action. Structural analysis of the most active peptide <b>2</b> evidenced that the improved biological activity of peptide <b>2</b> is the consequence of a combination of higher biostability, higher α helical content, and ability to reduce membrane fluidity and to adopt a distorted helix, bent in correspondence of Aib<sup>8</sup>. Overall, this study has shown how a strategic single amino acid substitution is sufficient to enlarge the spectrum of activity of the original peptide <b>1</b>, and improve its biological properties for therapeutic purposes, thus paving the way to optimize AMPs for the development of new broad-spectrum anti-infective agents.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141287408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance. 具有更强抗疟性能的 3 位双环内喹啉类喹诺酮。
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-12 Epub Date: 2024-06-11 DOI: 10.1021/acsinfecdis.4c00140
Sovitj Pou, Rolf W Winter, Rozalia A Dodean, Katherine Liebman, Yuexin Li, Michael W Mather, Binod Nepal, Aaron Nilsen, Mason J Handford, Teresa M Riscoe, Sydney Laxson, Payton J Kirtley, Maya Aleshnick, Lev N Zakharov, Jane X Kelly, Martin J Smilkstein, Brandon K Wilder, Sandhya Kortagere, Akhil B Vaidya, P Holland Alday, J Stone Doggett, Michael K Riscoe
{"title":"3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance.","authors":"Sovitj Pou, Rolf W Winter, Rozalia A Dodean, Katherine Liebman, Yuexin Li, Michael W Mather, Binod Nepal, Aaron Nilsen, Mason J Handford, Teresa M Riscoe, Sydney Laxson, Payton J Kirtley, Maya Aleshnick, Lev N Zakharov, Jane X Kelly, Martin J Smilkstein, Brandon K Wilder, Sandhya Kortagere, Akhil B Vaidya, P Holland Alday, J Stone Doggett, Michael K Riscoe","doi":"10.1021/acsinfecdis.4c00140","DOIUrl":"10.1021/acsinfecdis.4c00140","url":null,"abstract":"<p><p>ELQ-300 is a potent antimalarial drug with activity against blood, liver, and vector stages of the disease. A prodrug, <b>ELQ-331</b>, exhibits reduced crystallinity and improved in vivo efficacy in preclinical testing, and currently, it is in the developmental pipeline for once-a-week dosing for oral prophylaxis against malaria. Because of the high cost of developing a new drug for human use and the high risk of drug failure, it is prudent to have a back-up plan in place. Here we describe <b>ELQ-596</b>, a member of a new subseries of 3-biaryl-ELQs, with enhanced potency in vitro against multidrug-resistant <i>Plasmodium falciparum</i> parasites. <b>ELQ-598</b>, a prodrug of <b>ELQ-596</b> with diminished crystallinity, is more effective vs murine malaria than its progenitor <b>ELQ-331</b> by 4- to 10-fold, suggesting that correspondingly lower doses could be used to protect and cure humans of malaria. With a longer bloodstream half-life in mice compared to its progenitor, <b>ELQ-596</b> highlights a novel series of next-generation ELQs with the potential for once-monthly dosing for protection against malaria infection. Advances in the preparation of 3-biaryl-ELQs are presented along with preliminary results from experiments to explore key structure-activity relationships for drug potency, selectivity, pharmacokinetics, and safety.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141304769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating Penetration and Antimicrobial Activity of Vector-Bicycle Conjugates. 研究载体-自行车共轭物的渗透性和抗菌活性
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-12 Epub Date: 2024-06-12 DOI: 10.1021/acsinfecdis.3c00427
Andreas Hadjicharalambous, Hector Newman, Nick Lewis, Catherine Rowland, Nikolaos Bournakas, Steven J Stanway, Michael Dawson, Michael J Skynner, Paul Beswick
{"title":"Investigating Penetration and Antimicrobial Activity of Vector-Bicycle Conjugates.","authors":"Andreas Hadjicharalambous, Hector Newman, Nick Lewis, Catherine Rowland, Nikolaos Bournakas, Steven J Stanway, Michael Dawson, Michael J Skynner, Paul Beswick","doi":"10.1021/acsinfecdis.3c00427","DOIUrl":"10.1021/acsinfecdis.3c00427","url":null,"abstract":"<p><p>Growing antibiotic resistance is rapidly threatening the efficacy of treatments for Gram-negative infections. Bicycle molecules, constrained bicyclic peptides from diverse libraries generated by bacteriophage display that bind with high affinity to a chosen target are a potential new class of antibiotics. The generally impermeable bacterial outer membrane currently limits the access of peptides to bacteria. The conjugation of membrane active peptides offers an avenue for outer membrane penetration. Here, we investigate which physicochemical properties of a specific membrane active peptide (MAP), derived from ixosin-B, could be tweaked to enhance the penetration of conjugates by generating multiple MAP-Bicycle conjugate variants. We demonstrate that charge and hydrophobicity are important factors, which enhance penetration and, therefore, antimicrobial potency. Interestingly, we show that induction of secondary structure, but not a change in amphipathicity, is vital for effective penetration of the Gram-negative outer membrane. These results offer insights into the ways vectors could be designed to deliver Bicycle molecules (and other cargos) through biological membranes.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Celebrating a Decade of Trailblazing Research─Collection of Highly Cited Articles Each Year from ACS Infectious Diseases. 庆祝开拓性研究十年--ACS 感染性疾病杂志每年高被引论文集。
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-12 Epub Date: 2024-06-06 DOI: 10.1021/acsinfecdis.4c00381
Jayanta Haldar
{"title":"Celebrating a Decade of Trailblazing Research─Collection of Highly Cited Articles Each Year from <i>ACS Infectious Diseases</i>.","authors":"Jayanta Haldar","doi":"10.1021/acsinfecdis.4c00381","DOIUrl":"10.1021/acsinfecdis.4c00381","url":null,"abstract":"","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isobavachalcone Exhibits Potent Antifungal Efficacy by Inhibiting Enolase Activity and Glycolysis in Candida albicans. 异巴伐醌通过抑制白色念珠菌的烯醇化酶活性和糖酵解作用,显示出强大的抗真菌功效。
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-12 DOI: 10.1021/acsinfecdis.4c00399
Hao Wu, Zhe Ji, Xin Huang, Liping Li, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang
{"title":"Isobavachalcone Exhibits Potent Antifungal Efficacy by Inhibiting Enolase Activity and Glycolysis in <i>Candida albicans</i>.","authors":"Hao Wu, Zhe Ji, Xin Huang, Liping Li, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang","doi":"10.1021/acsinfecdis.4c00399","DOIUrl":"https://doi.org/10.1021/acsinfecdis.4c00399","url":null,"abstract":"<p><p>Invasive fungal diseases (IFDs) are becoming increasingly acknowledged as a significant concern linked to heightened rates of morbidity and mortality. Regrettably, the available antifungal therapies for managing IFDs are constrained. Emerging evidence indicates that enolase holds promise as a potential target protein for combating IFDs; however, there is currently a deficiency in antifungal medications specifically targeting enolase. This study establishes that isobavachalcone (IBC) exhibits noteworthy antifungal efficacy both in vitro and in vivo. Moreover, our study has demonstrated that IBC effectively targets Eno1 in <i>Candida albicans</i> (CaEno1), resulting in the suppression of the glycolytic pathway. Additionally, our research has indicated that IBC exhibits a higher affinity for CaEno1 compared to human Eno1 (hEno1), with the presence of isoprenoid in the side chain of IBC playing a crucial role in its ability to inhibit enolase activity. These findings contribute to the comprehension of antifungal approaches that target Eno1, identifying IBC as a potential inhibitor of Eno1 in human pathogenic fungi.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifunctional Nanosystem for Dual Anti-Inflammatory and Antibacterial Photodynamic Therapy in Infectious Diabetic Wounds. 用于糖尿病感染性伤口的双重消炎抗菌光动力疗法的多功能纳米系统
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-11 DOI: 10.1021/acsinfecdis.4c00306
Mohammad Sadik Ali, Hima Sree Buddhiraju, Mounika Gubige, Apoorva Basa, Gnaneshwar Gupta K, Bantal Veeresh, Aravind Kumar Rengan
{"title":"Multifunctional Nanosystem for Dual Anti-Inflammatory and Antibacterial Photodynamic Therapy in Infectious Diabetic Wounds.","authors":"Mohammad Sadik Ali, Hima Sree Buddhiraju, Mounika Gubige, Apoorva Basa, Gnaneshwar Gupta K, Bantal Veeresh, Aravind Kumar Rengan","doi":"10.1021/acsinfecdis.4c00306","DOIUrl":"https://doi.org/10.1021/acsinfecdis.4c00306","url":null,"abstract":"<p><p>Infectious diabetic wounds present a substantial challenge, characterized by inflammation, infection, and delayed wound healing, leading to elevated morbidity and mortality rates. In this work, we developed a multifunctional lipid nanoemulsion containing quercetin, chlorine e6, and rosemary oil (QCRLNEs) for dual anti-inflammatory and antibacterial photodynamic therapy (APDT) for treating infectious diabetic wounds. The QCRLNEs exhibited spherical morphology with a size of 51 nm with enhanced encapsulation efficiency, skin permeation, and localized delivery at the infected wound site. QCRLNEs with NIR irradiation have shown excellent wound closure and antimicrobial properties in vitro, mitigating the nonselective cytotoxic behavior of PDT. Also, excellent biocompatibility and anti-inflammatory and wound healing responses were observed in zebrafish models. The infected wound healing properties in <i>S. aureus</i>-infected diabetic rat models indicated re-epithelization and collagen deposition with no signs of inflammation. This multifaceted approach using QCRLNEs with NIR irradiation holds great promise for effectively combating oxidative stress and bacterial infections commonly associated with infected diabetic wounds, facilitating enhanced wound healing and improved clinical outcomes.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infection and the Glycome─New Insights into Host Response. 感染与糖粒--宿主反应的新见解。
IF 4 2区 医学
ACS Infectious Diseases Pub Date : 2024-07-11 DOI: 10.1021/acsinfecdis.4c00315
F Ifthiha Mohideen, Lara K Mahal
{"title":"Infection and the Glycome─New Insights into Host Response.","authors":"F Ifthiha Mohideen, Lara K Mahal","doi":"10.1021/acsinfecdis.4c00315","DOIUrl":"https://doi.org/10.1021/acsinfecdis.4c00315","url":null,"abstract":"<p><p>Glycans play critical roles in the host-pathogen interactions leading to infection. However, we still understand very little about the dynamic nature of glycosylation in response to infection and its function in modulating host immunity. Many of the host proteins involved in immune defense are glycoproteins. Furthermore, the innate immune system recognizes glycans. The glycoform of a protein can impact proteolytic stability, receptor interactions, serum half-life, and other aspects. New, cutting-edge chemical biology tools are shedding light on the interplay between infection and the host glycome. In this review, we highlight new work on the importance of dynamic glycosylation of host proteins in the innate and adaptive immune pathways in response to infection. These include recent findings on altered glycoprofiles of mucins, complement components, and antibodies.</p>","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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