ACS Infectious Diseases最新文献_第10页

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Letícia Alves Borghezan, Lara Cândida de Sousa Machado, Iara Barreto Neves Oliveira, Mírian Ívens Fagundes, Nicoly Silveira Apolidório, Renato Canevari Dutra da Silva, Victor Garcia Freire, Antonio Augusto Schafer, Rahisa Scussel and Ricardo Andrez Machado-de-Ávila*,

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Michael J. Wilhelm*, Mohammad Sharifian Gh., Bruk Mensa, Gabriella L. Howell, William F. DeGrado* and Hai-Lung Dai,

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Alex Odoom, Abdul-Halim Osman and Christian K.O Dzuvor*,

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Terri C. Lovell, Heidi A. F. Dewling, Cynthia Li, Hery W. Lee, Calvin J. Gordon, Dana Kocincova, Maulik D. Badmalia, Egor P. Tchesnokov, Matthias Götte and Gonzalo Cosa*,

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Recent Advances in Immunotherapeutic and Vaccine-Based Approaches for the Treatment of Drug-Resistant Bacterial Infections. 免疫治疗和基于疫苗的方法治疗耐药细菌感染的最新进展。

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13 Epub Date: 2025-05-02 DOI: 10.1021/acsinfecdis.5c00001

Alex Odoom, Abdul-Halim Osman, Christian K O Dzuvor

{"title":"Recent Advances in Immunotherapeutic and Vaccine-Based Approaches for the Treatment of Drug-Resistant Bacterial Infections.","authors":"Alex Odoom, Abdul-Halim Osman, Christian K O Dzuvor","doi":"10.1021/acsinfecdis.5c00001","DOIUrl":"10.1021/acsinfecdis.5c00001","url":null,"abstract":"Antimicrobial resistance poses a grave threat to global public health. Although new antibiotics are urgently needed, most share resistance mechanisms with existing drugs, thereby necessitating the development of alternative antibacterial therapeutics. Various immunotherapeutic agents, including monoclonal antibodies, therapeutic vaccines, cellular therapies, and immunomodulators, have been developed and explored to treat drug-resistant bacterial infections. This review comprehensively summarizes recent advancements in immunotherapies and vaccine-based approaches as alternative strategies to combat drug-resistant bacterial infections. Our findings indicate that immunotherapy offers several advantages over traditional antibiotics, such as enhanced specificity, long-term effects, overcoming resistance mechanisms, broad applicability, potential for combination therapies, personalized medicine, and reduced toxicity. Also, formulation and delivery strategies, including nanoparticles, liposomes, cellular vehicles, and diverse administration routes, have been employed to improve the efficacy and targeting of these immunotherapeutic agents. In-depth evaluations of promising preclinical and clinical studies demonstrate their potential effectiveness against pathogens such as Pseudomonas aeruginosa, Escherichia coli, Mycobacterium tuberculosis, Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, and Helicobacter pylori. These suggest that immunotherapy is a promising alternative to address the growing challenge of drug-resistant bacterial infections, potentially revolutionizing infection management strategies.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":" ","pages":"1366-1402"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Charlotte Quentin-Froignant, Ann E. Tollefson, Anna Cline-Smith, Sandrine Kappler-Gratias, Nicolas Landrein, Vincent Roy, Luigi A. Agrofoglio, Karoly Toth*, Harald Wodrich* and Franck Gallardo*,

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Akanksha M. Pandey, Satish R. Malwal, Mariana Valladares-Delgado, Liesangerli Labrador-Fagúndez, Bruno G. Stella, Luis José Díaz-Pérez, André Rey-Cibati, Davinder Singh, Marianna Stampolaki, Sangjin Hong, Robert B. Gennis, Antonios Kolocouris, Gustavo Benaim* and Eric Oldfield*,

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Babatunde Samuel Obadawo, Priscila Cristina Bartolomeu Halicki, Kindra L. Becker, Jessica C. Seeliger, Kyle H. Rohde* and Steven J. Sucheck*,

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Validation of a Cystic Fibrosis Co-Culture Model for the Identification of Dual Acting Compounds with Antibiotic and Antibiotic Adjuvant Properties. 囊性纤维化共培养模型的验证，用于鉴定具有抗生素和抗生素佐剂特性的双重作用化合物。

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13 Epub Date: 2025-05-11 DOI: 10.1021/acsinfecdis.5c00226

Anne E Mattingly, Haoting Li, Roberta J Melander, Christian Melander

{"title":"Validation of a Cystic Fibrosis Co-Culture Model for the Identification of Dual Acting Compounds with Antibiotic and Antibiotic Adjuvant Properties.","authors":"Anne E Mattingly, Haoting Li, Roberta J Melander, Christian Melander","doi":"10.1021/acsinfecdis.5c00226","DOIUrl":"10.1021/acsinfecdis.5c00226","url":null,"abstract":"Infections in the lungs of cystic fibrosis (CF) patients are often polymicrobial in nature, typically comprising Pseudomonas aeruginosa and Staphylococcus aureus. Compounds that act as an antimicrobial agent against one of these pathogens, and as an antibiotic adjuvant against the other, could provide a valuable approach to treating such infections, however a model that mimics the unique environment found with the CF lung is required for the identification and characterization of such molecules. To address this, we employed a S. aureus/P. aeruginosa coculture screening model in synthetic sputum, and identified compounds from our in-house library that simultaneously have potent anti-S. aureus activity, and potentiate colistin against colistin-resistant P. aeruginosa. The two lead compounds, 12F1 and 12G9, control growth of both species when dosed alongside sub-inhibitory concentrations of colistin, highlighting the potential of using a single molecule as both an antibiotic and antibiotic adjuvant to target multiple species in polymicrobial infections, as well as the importance of conducting activity screens in clinically relevant media.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":" ","pages":"1686-1696"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mechanism of Inhibition of the Active Triphosphate Form of 2'-α-Fluoro,2'-β-bromouridine against Yellow Fever Virus RNA-Dependent RNA Polymerase. 活性三磷酸形式2′-α-氟，2′-β-溴化吡啶抑制黄热病病毒RNA依赖性RNA聚合酶的机制

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13 Epub Date: 2025-05-05 DOI: 10.1021/acsinfecdis.5c00086

Calvin Joel Gordon, Simon Maximus Walker, Julia Christine LeCher, Franck Amblard, Raymond Felix Schinazi, Matthias Götte

{"title":"Mechanism of Inhibition of the Active Triphosphate Form of 2'-α-Fluoro,2'-β-bromouridine against Yellow Fever Virus RNA-Dependent RNA Polymerase.","authors":"Calvin Joel Gordon, Simon Maximus Walker, Julia Christine LeCher, Franck Amblard, Raymond Felix Schinazi, Matthias Götte","doi":"10.1021/acsinfecdis.5c00086","DOIUrl":"10.1021/acsinfecdis.5c00086","url":null,"abstract":"Yellow fever virus (YFV) is a deadly mosquito-borne flavivirus that infects approximately 200,000 individuals each year. YFV outbreak and infection are persistent throughout South America and Africa, demonstrating significant epidemic potential. Although an approved and effective vaccine exists, the zoonotic nature of YFV undermines any potential eradication efforts, highlighting the need for effective, direct-acting antivirals. Essential for viral replication, RNA-dependent RNA polymerase (RdRp) is a proven therapeutic target. A prominent example includes sofosbuvir, a 2'-α-fluoro,2'-β-methyluridine prodrug approved for the treatment of hepatitis C virus (HCV), that has demonstrated efficacy against YFV in vitro. A structurally similar 2'-α-fluoro, 2'-β-bromouridine prodrug has exhibited potent anti-YFV activity both in vitro and in vivo. Here, we expressed the full-length nonstructural protein 5 from YFV in insect cells to investigate the active triphosphate form of these prodrugs. Enzyme kinetics indicate that both nucleotide analogs are incorporated less efficiently than UTP. Once incorporated, the analogs inhibit RNA synthesis through immediate chain termination. Omitting the 2'-β-modification alleviates the inhibition of RNA synthesis, highlighting its role in eliciting an antiviral effect. S282T is a well-characterized mutation in motif B of HCV RdRp that confers resistance to sofosbuvir. We discovered that the analogous substitution in YFV (S603T) improved discrimination against the 2'-α-fluoro,2'-β-modified uridine analogs. Collectively, our findings explain their observed anti-YFV activity and identify a conserved mechanism of resistance. Based on its in vivo efficacy and mechanism of action, the 2'-fluoro,2'-bromouridine prodrug shows potential for future therapeutic strategies against YFV.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":" ","pages":"1528-1538"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0