ACS Infectious Diseases最新文献_第10页

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Timothy J. Kotzé, Konrad J. Mostert, Riyad Domingo, Xu Wang, Wessel J. A. Moolman, Hailey S. Butman, Abigail Pepin, Kyle T. McKay, Deon P. Neveling, Joanna C. Evans, Valerie Mizrahi, Willem A. L. van Otterlo, Cynthia S. Dowd* and Erick Strauss*,

引用次数: 0

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Dipendra Bhandari, Leighton Coates, Annie Aniana, John M. Louis, Peter V. Bonnesen* and Andrey Kovalevsky*,

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Laurent Bédouet, Anne Beilvert, Emeline Servais, Florentina Pascale, Saïda Homayra Ghegediban, Julien Namur and Laurence Moine*,

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Design of Epitopes from Treponema pallidum Lipoprotein Antigens for Syphilis Diagnosis and Treatment Prognosis. 梅毒螺旋体脂蛋白抗原表位设计对梅毒诊断和治疗预后的影响。

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13 Epub Date: 2025-05-23 DOI: 10.1021/acsinfecdis.5c00155

Letícia Alves Borghezan, Lara Cândida de Sousa Machado, Iara Barreto Neves Oliveira, Mírian Ívens Fagundes, Nicoly Silveira Apolidório, Renato Canevari Dutra da Silva, Victor Garcia Freire, Antonio Augusto Schafer, Rahisa Scussel, Ricardo Andrez Machado-de-Ávila

{"title":"Design of Epitopes from Treponema pallidum Lipoprotein Antigens for Syphilis Diagnosis and Treatment Prognosis.","authors":"Letícia Alves Borghezan, Lara Cândida de Sousa Machado, Iara Barreto Neves Oliveira, Mírian Ívens Fagundes, Nicoly Silveira Apolidório, Renato Canevari Dutra da Silva, Victor Garcia Freire, Antonio Augusto Schafer, Rahisa Scussel, Ricardo Andrez Machado-de-Ávila","doi":"10.1021/acsinfecdis.5c00155","DOIUrl":"10.1021/acsinfecdis.5c00155","url":null,"abstract":"Syphilis, a multistage sexually transmitted infection, causes severe complications if untreated. Accurate diagnosis remains difficult due to the low protein content of Treponema pallidum and in vitro culture difficulty. Advances in immunoproteomics have identified key antigens that enhance diagnostic accuracy. Epitopes of immunodominant antigen proteins Tp0171, Tp0435, Tp0574, Tp0684, and Tp0453 were designed by bioinformatics tools, and mimetic peptides were chemically synthesized. A diagnostic accuracy cross-sectional study was performed to validate a prototype technology as a serodiagnosis platform for syphilis. Five peptides were used as antigens in a peptide-based ELISA against serum samples from syphilis-positive or noninfected patients (n = 122). CETp0435 achieved 100% sensitivity and specificity with a high accuracy. The peptides CETp0171 and CETp0574 demonstrated high diagnostic performance, with sensitivity above 83% and specificity >90%. Peptides CETp0684 and CETp0453 exhibited sensitivity above 80% and 90%, respectively; CETp0453 showed reduced specificity (∼66%). The peptides CETp0435 and CETp0171 maintained high diagnostic accuracy across syphilis stages, with a sensitivity above 83% and a specificity exceeding 97%. Peptides CETp0435 and CETp0171 effectively monitored syphilis treatment, as evidenced by the significant post-treatment decline in serum antibody levels, supporting their potential for evaluating the therapeutic efficacy. We obtained two epitopes mimetic peptides as advantageous antigens for serodiagnosis and treatment monitoring.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":" ","pages":"1606-1622"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Letícia Alves Borghezan, Lara Cândida de Sousa Machado, Iara Barreto Neves Oliveira, Mírian Ívens Fagundes, Nicoly Silveira Apolidório, Renato Canevari Dutra da Silva, Victor Garcia Freire, Antonio Augusto Schafer, Rahisa Scussel and Ricardo Andrez Machado-de-Ávila*,

引用次数: 0

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Michael J. Wilhelm*, Mohammad Sharifian Gh., Bruk Mensa, Gabriella L. Howell, William F. DeGrado* and Hai-Lung Dai,

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Alex Odoom, Abdul-Halim Osman and Christian K.O Dzuvor*,

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IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Terri C. Lovell, Heidi A. F. Dewling, Cynthia Li, Hery W. Lee, Calvin J. Gordon, Dana Kocincova, Maulik D. Badmalia, Egor P. Tchesnokov, Matthias Götte and Gonzalo Cosa*,

引用次数: 0

Recent Advances in Immunotherapeutic and Vaccine-Based Approaches for the Treatment of Drug-Resistant Bacterial Infections. 免疫治疗和基于疫苗的方法治疗耐药细菌感染的最新进展。

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13 Epub Date: 2025-05-02 DOI: 10.1021/acsinfecdis.5c00001

Alex Odoom, Abdul-Halim Osman, Christian K O Dzuvor

{"title":"Recent Advances in Immunotherapeutic and Vaccine-Based Approaches for the Treatment of Drug-Resistant Bacterial Infections.","authors":"Alex Odoom, Abdul-Halim Osman, Christian K O Dzuvor","doi":"10.1021/acsinfecdis.5c00001","DOIUrl":"10.1021/acsinfecdis.5c00001","url":null,"abstract":"Antimicrobial resistance poses a grave threat to global public health. Although new antibiotics are urgently needed, most share resistance mechanisms with existing drugs, thereby necessitating the development of alternative antibacterial therapeutics. Various immunotherapeutic agents, including monoclonal antibodies, therapeutic vaccines, cellular therapies, and immunomodulators, have been developed and explored to treat drug-resistant bacterial infections. This review comprehensively summarizes recent advancements in immunotherapies and vaccine-based approaches as alternative strategies to combat drug-resistant bacterial infections. Our findings indicate that immunotherapy offers several advantages over traditional antibiotics, such as enhanced specificity, long-term effects, overcoming resistance mechanisms, broad applicability, potential for combination therapies, personalized medicine, and reduced toxicity. Also, formulation and delivery strategies, including nanoparticles, liposomes, cellular vehicles, and diverse administration routes, have been employed to improve the efficacy and targeting of these immunotherapeutic agents. In-depth evaluations of promising preclinical and clinical studies demonstrate their potential effectiveness against pathogens such as Pseudomonas aeruginosa, Escherichia coli, Mycobacterium tuberculosis, Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, and Helicobacter pylori. These suggest that immunotherapy is a promising alternative to address the growing challenge of drug-resistant bacterial infections, potentially revolutionizing infection management strategies.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":" ","pages":"1366-1402"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4 2区医学

ACS Infectious Diseases Pub Date : 2025-06-13

Charlotte Quentin-Froignant, Ann E. Tollefson, Anna Cline-Smith, Sandrine Kappler-Gratias, Nicolas Landrein, Vincent Roy, Luigi A. Agrofoglio, Karoly Toth*, Harald Wodrich* and Franck Gallardo*,

引用次数: 0