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{"title":"Study on the Mechanism and Potential of Corbicula fluminea (Asian Clam) in Removing Copper and Cadmium from Aquaculture Ponds.","authors":"Jiahua Zhang, Jie Wang, Zhaojun Gu, Xingguo Liu","doi":"10.1007/s10126-024-10389-7","DOIUrl":"https://doi.org/10.1007/s10126-024-10389-7","url":null,"abstract":"<p><p>The issue of heavy metal pollution in aquaculture ponds is becoming increasingly severe, posing a significant threat to the healthy development of the aquaculture industry. Heavy metals such as cadmium and copper accumulate in ponds, not only exerting toxic effects on aquatic organisms and affecting their growth and reproduction but also endangering human health through the food chain. Bioremediation, as a green and environmentally friendly technology, utilizes specific organisms to absorb, transform, and immobilize heavy metals. We examined metal accumulation, traditional metal-related biomarkers, alongside transcriptomic and tissue histological analyses, in the hepatopancreas of Corbicula fluminea following a 14-day exposure to copper (20 µg/L), cadmium (20 µg/L), or combined copper-cadmium treatments (20 µg/L Cu and 20 µg/L Cd). Metal exposure led to notable metal accumulation in the clam's hepatopancreas. Analysis of traditional biomarkers revealed signs of cellular injury and oxidative stress in clams post-metal exposure. Transcriptomic analysis across the three treatment groups revealed disruptions in immune response, response to metal ion, and energy metabolism, characterized by differential expression levels of key genes such as ABCA3, MYD88, TOLLIP, TBK1, C2, C4, c-Myc, SYK, and SAMHD1. These findings deepen our understanding of the adverse effects of metal exposure on freshwater organisms and evaluate the potential of Corbicula fluminea for removing heavy metals from aquaculture ponds.</p>","PeriodicalId":690,"journal":{"name":"Marine Biotechnology","volume":"27 1","pages":"2"},"PeriodicalIF":2.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glia-related Acute Effects of Risperidone and Haloperidol in Hippocampal Slices and Astrocyte Cultures from Adult Wistar Rats: A Focus on Inflammatory and Trophic Factor Release.","authors":"Amanda da Silva, Larissa Daniele Bobermin, Camila Leite Santos, Rômulo Rodrigo de Souza Almeida, Lílian Juliana Lissner, Tiago Marcon Dos Santos, Marina Seady, Marina Concli Leite, Angela T S Wyse, Carlos-Alberto Gonçalves, André Quincozes-Santos","doi":"10.1007/s11064-024-04273-y","DOIUrl":"https://doi.org/10.1007/s11064-024-04273-y","url":null,"abstract":"<p><p>Antipsychotics are drugs commonly prescribed to treat a variety of psychiatric conditions. They are classified as typical and atypical, depending on their affinity for dopaminergic and serotonergic receptors. Although neurons have been assumed to be the major mediators of the antipsychotic pharmacological effects, glia, particularly astrocytes, have emerged as important cellular targets for these drugs. In the present study, we investigated the effects of acute treatments with the antipsychotics risperidone and haloperidol of hippocampal slices and astrocyte cultures, focusing on neuron-glia communication and how antipsychotics act in astrocytes. For this, we obtained hippocampal slices and primary astrocyte cultures from 30-day-old Wistar rats and incubated them with risperidone or haloperidol (1 and 10 μM) for 30 min and 24 h, respectively. We evaluated metabolic and enzymatic activities, the glutathione level, the release of inflammatory and trophic factors, as well as the gene expression of signaling proteins. Haloperidol increased glucose metabolism; however, neither of the tested antipsychotics altered the glutathione content or glutamine synthetase and Na⁺K⁺-ATPase activities. Haloperidol induced a pro-inflammatory response and risperidone promoted an anti-inflammatory response, while both antipsychotics seemed to decrease trophic support. Haloperidol and risperidone increased Nrf2 and HO-1 gene expression, but only haloperidol upregulated NFκB and AMPK gene expression. Finally, astrocyte cultures confirmed the predominant effect of the tested antipsychotics on glia and their opposite effects on astrocytes. Therefore, antipsychotics cause functional alterations in the hippocampus. This information is important to drive future research for strategies to attenuate antipsychotics-induced neural dysfunction, focusing on glia.</p>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"50 1","pages":"22"},"PeriodicalIF":3.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Source identification of water distribution system contamination based on simulated annealing-particle swarm optimization algorithm.","authors":"Zhenliang Liao, Xingyang Shi, Yangting Liao, Zhiyu Zhang","doi":"10.1007/s10661-024-13382-8","DOIUrl":"https://doi.org/10.1007/s10661-024-13382-8","url":null,"abstract":"<p><p>Ensuring the safety of water supplies is critical for urban areas requires rapid response when water quality anomalies are detected in the pipeline network. Prompt action is essential to prevent widespread contamination, protect public health, and mitigate potential social unrest. The particle swarm optimization (PSO) algorithm has faced challenges for contamination source identification (CSI) in water distribution systems (WDS), primarily due to its susceptibility to locally optimal solutions. Addressing this issue is critical to quickly and accurately identify contamination sources. Therefore, this research integrates the Metropolis criterion from the simulated annealing (SA) algorithm into a SA-PSO algorithm, to overcome the limitations of PSO. This study conducts contamination localization experiments using SA-PSO, with the publicly available NET-3 pipeline network as the case to generate sudden contamination events. By collecting pollutant concentration data from predefined monitoring points over time through simulation, a simulation-optimization inverse location model is constructed to fit the pollutant concentrations at each monitoring point. The results of the case study show that SA-PSO outperforms PSO in both speed and accuracy in solving the CSI problem, and the findings provide an efficient and effective contamination localization tool for urban water supply management.</p>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"196 12","pages":"1216"},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on the DONOVAN: Addiction and Recovery as a Continuum.","authors":"Leslie R Dye","doi":"10.1007/s13181-024-01042-9","DOIUrl":"https://doi.org/10.1007/s13181-024-01042-9","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated computational approaches for identification of potent pyrazole-based glycogen synthase kinase-3β (GSK-3β) inhibitors: 3D-QSAR, virtual screening, docking, MM/GBSA, EC, MD simulation studies.","authors":"Desu Gayathri Niharika, Punam Salaria, M Amarendar Reddy","doi":"10.1007/s11030-024-11026-0","DOIUrl":"https://doi.org/10.1007/s11030-024-11026-0","url":null,"abstract":"<p><p>Glycogen synthase kinase-3β (GSK-3β) has emerged as a crucial target due to its substantial contribution in various cellular processes. Dysfunctional GSK-3β activity can lead to ion channel disturbances, sustain abnormal excitability, and contribute to the pathogenesis of epilepsy and other GSK-3β-related disorders. A set of 82 pyrazole analogs was utilized to study its structural features using a three-dimensional quantitative structure-activity relationship (3D-QSAR), virtual screening, molecular docking, and molecular dynamics. The QSAR model, validated using internal and external methods, demonstrated robustness with a high correlation coefficient r²_training = 0.99, cross-validation coefficient q² = 0.79, r²_test = 0.69, and r²_external = 0.74. The \"Average of Actives\" in the Activity Atlas model identified 17 molecules as active. Subsequent pharmacophore-based virtual screening of 17 actives yielded 70 compounds, which were selected as the prediction set to determine the potential GSK-3β inhibitors. Docking studies pinpointed compound P66 as the promising lead compound, with a docking score of - 10.555 kcal/mol. These findings were further supported by electrostatic potential (ESP), electrostatic complementarity (EC), and Molecular Mechanics/Generalized Born Surface Area (MM/GBSA) analyses. Furthermore, a 500 ns molecular dynamics (MD) simulation confirmed the structural and conformational stability of the lead complex throughout the simulation period. As a result, this study suggests that compound P66 holds the potential to be a potent lead candidate for the inhibition of GSK-3β, offering a novel therapeutic approach for GSK-3β related disorders, including epilepsy.</p>","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring α-synuclein Interaction Partners and their Potential Clinical Implications for Parkinson's Disease.","authors":"Yingfei Chen, Yanan Gu, Can Cao, Qiuying Zheng, Lili Sun, Wenyong Ding, Li Ma, Cui Wang, Wenli Zhang","doi":"10.1007/s11064-024-04250-5","DOIUrl":"https://doi.org/10.1007/s11064-024-04250-5","url":null,"abstract":"<p><p>Alpha-synuclein aggregates are strongly associated with Parkinson's disease (PD), a degenerative neurological disorder characterized by a progressive loss in motor functions. Our study aimed to unravel the potential interaction partners of α-synuclein for exploring the synucleinpathy of PD related to α-synuclein aggregates. α-synuclein was expressed in E.coli and purified by affinity chromatography followed by isolation and identification of its interaction partners using pulldown assay coupled with LC-MS/MS. The impacts of the identified interaction partners on PD were evaluated based on GSE205450 dataset. Consequently, 157 proteins were identified by the criteria of unique peptide = 5. Four proteins including ACO2, ANT1, ATP5F1B and CKB were confirmed using immunostaining coupled with α-synuclein-pulldown assay. Transcriptomics assay showed that the dominant biological processes influenced by α-synuclein interaction partners with differential expression were energy metabolism. Together with GSE205450, Western blot assay showed that α-synuclein interaction partners involved in energy metabolism were down-regulated in PD patients and the MPTP-lesioned mice. ROC curves indicated their clinical implications as diagnostic indices of PD. Using ANT1 as an example, we found that protein aggregates formed by ANT1 and α-synuclein predominantly solely appeared in the cells and mice with PD-like variations. Thereby, low levels of the interaction partners of α-synuclein associated with energy metabolism were associated with PD pathogenesis via forming protein aggregates. This study provides an insight into developing innovative targets on PD based on synucleinpathy.</p>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"50 1","pages":"23"},"PeriodicalIF":3.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance analysis of mesocosm-constructed wetland containing agricultural waste-derived substrates for treatment of wastewater.","authors":"Mamta Sharma, Neeta Raj Sharma, Rameshwar S Kanwar","doi":"10.1007/s10661-024-13411-6","DOIUrl":"https://doi.org/10.1007/s10661-024-13411-6","url":null,"abstract":"<p><p>Integrating native ornamental plants with substrate amended with lignocellulosic biomass and biochar in vertical sub-surface flow constructed wetlands offers a novel and effective approach to wastewater treatment. This study evaluates the potential of mesocosm constructed wetland systems using native ornamental plants (Canna indica, Lilium wallichianum, and Tagetes erecta) grown in substrates amended with lignocellulosic biomass and biochar. The influent and effluent were analyzed for pH, total dissolved solids (TDS), biochemical oxygen demand (BOD), chemical oxygen demand (COD), phosphorus (PO₄-P), and nitrogen forms, i.e., ammonia (NH₄-N) and nitrate (NO₃-N) for 5 weeks. Investigated mesocosms showed an average removal efficiency of 49.21% for BOD, 53.76% for COD, 40.64% for NH₄-N, 41.76% for NO₃-N, and 21.53% for PO₄-P. Canna indica demonstrated the highest removal efficiencies, achieving 58.19% for BOD and 64.49% for COD, followed by Lilium wallichianum with 56.12% for BOD and 62% for COD, while Tagetes erecta showed lower efficiencies of 49.63% for BOD and 52.24% for COD. The result shows that the designed mesocosms are a promising nature-based alternative to the technologically complex and expensive conventional technologies, with numerous additional ecological benefits. This study also indicates that the locally available organic materials are effective substrate components for constructed wetlands and after their use in wetlands; these digested organic materials may further be used as an effective source of nutrient-rich fertilizers or soil amendments in agriculture.</p>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"196 12","pages":"1220"},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of nutrients from synthetic wastewater by different Brazilian chlorophyte strains in batch bioreactors under various light regimes.","authors":"Gabriel Bolani, Caio Roberto Soares Bragança, Sarah Regina Vargas","doi":"10.1007/s10661-024-13389-1","DOIUrl":"https://doi.org/10.1007/s10661-024-13389-1","url":null,"abstract":"<p><p>With the increase in pollution and improper waste disposal, aquatic ecosystems are experiencing escalating degradation leading to various detrimental effects, including eutrophication and adverse impacts on the health of the population reliant on these water resources. Consequently, microalgae have demonstrated efficacy in nutrient removal, minimal environmental disruption, and superior cost-effectiveness in comparison to traditional treatment methods. Thus, this study aimed to investigate wastewater treatment in an aerobic batch system, using two strains of non-axenic mixotrophic chlorophytes, Chlorella sp. and Desmodesmus sp., across distinct light regimes: continuous light exposure for 24 h, a photoperiod of 12 h light and 12 h darkness, and complete absence of light for 24 h. The Desmodesmus sp. strain exhibited superior efficiency in the proposed biological treatment, yielding more favorable nutrient removal results across all conditions, except for total nitrogen removal under the 24-h continuous light condition in which Chlorella sp. removed 0.199 ± 0.02% by biomass. In other parameters, Desmodesmus sp., remediated by biomass 0.408 ± 0.013% of inorganic phosphorus in 24 h light, 0.372 ± 0.011% of COD and 0.416 ± 0.004% of carbohydrate in 24 h dark. While Chlorella sp. removed 0.221 ± 0.01% of inorganic phosphorus in 24 h light, 0.164 ± 0.02% of COD in 24 h light and 0.214 ± 0.002% of carbohydrates in 24 h dark. Nevertheless, both strains displayed potential as viable alternatives for wastewater biological treatment, indicating that nutrient removal is achievable across all tested light conditions, albeit with variations in efficiency depending on the specific nutrient type.</p>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"196 12","pages":"1218"},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of groundwater quality of unconfined aquifers in an urbanized area using the water quality index method.","authors":"Mingjun Zhu, Yueqing Xie, Jingjing Su, Shiang Lu","doi":"10.1007/s11356-024-35562-2","DOIUrl":"https://doi.org/10.1007/s11356-024-35562-2","url":null,"abstract":"<p><p>This study performed an evaluation of the groundwater quality of unconfined aquifers in Yangzhou, located in the Yangtze River Delta, eastern China. The study area is the source area of the Eastern Route (ER) of the South-to-North Water Diversion Project (SNWDP), typical of the lower alluvial plain of the lower Yangtze River. Water samples from monitoring wells and domestic wells were collected to analyze common variables (pH, EC), major ions, trace metals, etc. The water quality index method was employed to evaluate groundwater quality in both eastern and western parts of the study area. The study found that the groundwater hydrochemistry is typical of HCO₃-Ca and HCO₃-Na, similar between the eastern and western parts of the study area. In addition, the eastern part of the study area is more affected by nitrate pollution than the western part due to agricultural activities. The water quality analysis suggests that the groundwater in the western region was slightly better than that in the eastern region. The comparison between different scenarios indicates that the water quality using only major ions can differ significantly from that using all chemical parameters, but may offer some preliminary insights into the groundwater quality useful for conducting further more detailed analysis. Our study shows that using the combination of major ions and heavy metals could provide relatively robust results of the groundwater quality in our study area. Our study has important implications for the assessment of groundwater quality in regions with similar conditions.</p>","PeriodicalId":545,"journal":{"name":"Environmental Science and Pollution Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Landscape degradation drives metal bioaccumulation in bats from Atlantic Forest cacao region, Brazil.","authors":"Julián Barillaro, Leticia Soto da Costa, Wilson Noel Gómez-Corea, Franger J García, Adailson Pereira de Souza, Ricardo Bovendorp","doi":"10.1007/s11356-024-35583-x","DOIUrl":"https://doi.org/10.1007/s11356-024-35583-x","url":null,"abstract":"","PeriodicalId":545,"journal":{"name":"Environmental Science and Pollution Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}