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{"title":"Elucidation of human metabolism of ADB-FUBIATA for population exposure assessment.","authors":"Alexandr Gish, Alexandre Peyré, Camille Richeval, Eric Pleignet, Victoire Cottereau, Jean-Michel Gaulier, Damien Alain Devault","doi":"10.1007/s11356-025-36571-5","DOIUrl":"https://doi.org/10.1007/s11356-025-36571-5","url":null,"abstract":"<p><p>At a time when synthetic drugs are emerging as a critical threat to users, the consumption of synthetic cannabinoid receptor agonists has become emblematic of the French overseas territory of Mayotte, aka \"la Chimique.\" On this island, 8 sampling campaigns of this drug were performed between September 22 and September 23: 193 samples were collected. Among them, 21 contained ADB-FUBIATA. This synthetic cannabinoid receptor agonist presented maximal concentrations. To verify the feasibility of further epidemiological studies based on wastewater and with a view to forensic and ecotoxicological concerns since metabolites are known to be capable of altering the environment, the authors studied the hepatic metabolism of ADB-FUBIATA using HLMs and LC-HMRS. For tracking ADB-FUBIATA, the apparently most relevant metabolite is proposed, i.e., the M03 metabolite (C₂₃H₂₆FN₃O₃, HMRS target must be [M⁺H⁺] m/z 412.2031) resulting from ADB-FUBIATA hepatic hydroxylation, but persistent in the wastewater context. This proposal remains cautious, since it is based on a metabolization rate of 10% estimated on the basis of the intensity of the chromatographic peak area. Nevertheless, to confirm the usefulness and viability of detecting ADB-FUBIATA metabolites in wastewater, it is necessary to carry out analytical confirmation on real samples.</p>","PeriodicalId":545,"journal":{"name":"Environmental Science and Pollution Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of conformational features and oligomerization of MMACHC by cobalamin variants: impact of the R161Q mutation in cblC disease.","authors":"Lisa Longo, Maria Assunta Costa, Rita Carrotta, Maria Rosalia Mangione, Vincenzo Martorana, Marco Tutone, Maria Grazia Ortore, Paula M Garcia-Franco, Sonia Vega, Adrian Velazquez-Campoy, Rosa Passantino, Silvia Vilasi","doi":"10.1007/s00249-025-01777-5","DOIUrl":"https://doi.org/10.1007/s00249-025-01777-5","url":null,"abstract":"<p><p>Vitamin B12 (cobalamin, Cbl) is a coordination compound of the cobalt, located at the center of a corrin ring composed of four pyrrolic-like groups. The cobalt ion can be bound to a variety of upper axial ligands, which vary among different cobalamin forms, including hydroxocobalamin (OHCbl), cyanocobalamin (CNCbl), methylcobalamin (MeCbl), and adenosylcobalamin (AdoCbl). MeCbl and AdoCbl are considered the biologically active forms, serving as cofactors in the metabolism of methylmalonic acid (MMA) and homocysteine (HCY). Impaired conversion of these metabolites leads to their pathological accumulation, resulting in severe cellular damage. This is precisely what occurs in cblC deficiency, a rare inborn disorder caused by mutations in the MMACHC protein, which plays a crucial role in binding and processing the various cobalamin forms. Mutations affecting MMACHC function impair its ability to correctly handle cobalamins, leading to the disease. In this study, we evaluated the impact of various cobalamin forms, specifically AdoCbl, MeCbl, and CNCbl, on the stability and oligomeric organization of the wild type MMACHC protein, using circular dichroism spectroscopy, native gel electrophoresis, and small-angle X-ray scattering. Moreover, isothermal titration calorimetry experiments provided insights into the thermodynamic parameters governing MMACHC binding to these cobalamins. In addition, we also assessed how the R161Q mutation in MMACHC alters the affinity of this protein for the different vitamin B12 forms, leading to decreased stability and impaired homodimerization, a process likely relevant to its functional role. Our findings provide molecular insights into cblC pathogenesis and advance our understanding of MMACHC structure-function relationships.</p>","PeriodicalId":548,"journal":{"name":"European Biophysics Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing Metal Phosphide Solid-Electrolyte Interphase for Stable Lithium Metal Batteries Through Electrified Interface Optimization and Synergistic Conversion.","authors":"Jung Been Park, Changhoon Choi, Min Sang Kim, Hyeongbeom Kang, Eunji Kwon, Seungho Yu, Dong-Wan Kim","doi":"10.1007/s40820-025-01813-1","DOIUrl":"https://doi.org/10.1007/s40820-025-01813-1","url":null,"abstract":"<p><p>Regulating the nucleation and growth of Li metal is crucial for achieving stable high-energy-density Li metal batteries (LMBs) without dendritic Li growth, severe volume expansion, and \"dead Li\" accumulation. Herein, we present a modulation layer composed of porous SnP_0.94/CoP p-n heterojunction particles (SCP), synthesized applying the Kirkendall effect. The unique heterointerfaces in the SCP induce a fully ionized depletion region and built-in electric field. This provides strong Li affinity, additional adsorption sites, and facilitated electron transfer, thereby guiding dendrite-free Li nucleation/growth with a low Li deposition overpotential. Moreover, the strategic design of the SCP, accounting for its reaction with Li, yields electronically conductive Co, lithiophilic Li-Sn alloy, and ionic conductive Li₃P during progressive cycles. The mixed electronic and ionic conductor (MEIC) ensure the long-term stability of the SCP modulation layer. With this layer, the SCP@Li symmetric cell maintains a low overpotential for 750 cycles even at a high current density of 5 mA cm^-2. Additionally, the LiFePO₄//SCP@Li full cell achieves an imperceptible capacity decay of 0.03% per cycle for 800 cycles at 0.5 C. This study provides insight into MEIC heterostructures for high-performance LMBs.</p>","PeriodicalId":714,"journal":{"name":"Nano-Micro Letters","volume":"17 1","pages":"315"},"PeriodicalIF":26.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocytes Regulate Brain State Transitions.","authors":"Alexei Verkhratsky, Max Gippert, Vladimir Parpura","doi":"10.1007/s11064-025-04468-x","DOIUrl":"https://doi.org/10.1007/s11064-025-04468-x","url":null,"abstract":"<p><p>We celebrate the life of our close friend and collaborator, Arne Schousboe, by writing this prose of the role of astrocytes in distinct aspects of arousal. Most animals exhibit cyclic behavioural transitions between sleep and wakefulness. Highly interconnected and complex networks of neurones, which release neurotransmitters, particularly noradrenaline, that target astrocytes by volume transmission, support the arousal system. Astrocyte noradrenergic signalling pathways are intricately connected to energy metabolism, whereby noradrenaline stimulates metabolism and leads to changes in cellular morphology, which is consistent with the maturation, territorial reach and complexity of these glial cells. We briefly discuss historic hypotheses contributing to the ever-going notion that cellular morphology and function affect each other. The message is that astrocytes contribute to sleep-wake transitions through the regulation of homeostatic control; these glial cells are responsible for ionostasis, metabolism, biosynthesis and degradation of neurotransmitters and the regulation of microcirculation and interstitial fluid flow. By regulating brain homeostasis, astrocytes in turn affect neuronal activity in the context of sleep-arousal regulation. \"It's complicated.\"^® (Arne Schousboe, Denmark).</p>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"50 4","pages":"218"},"PeriodicalIF":3.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broadscale reconnaissance of coral reefs from citizen science and deep learning.","authors":"Christopher L Lawson, Kathryn M Chartrand, Chris M Roelfsema, Aruna Kolluru, Peter J Mumby","doi":"10.1007/s10661-025-14261-6","DOIUrl":"10.1007/s10661-025-14261-6","url":null,"abstract":"<p><p>Coral reef managers require various forms of data. While monitoring is typically the preserve of scientists, there is an increasing need to collect larger scale, up-to-date data to prioritise limited conservation resources. Citizen science combined with novel technology may achieve data collection at the required scale, but the accuracy and feasibility of new tools must be assessed. Here, we show that a citizen science program that collects large field-of-view benthic images and analyses them using a combination of deep learning and online citizen scientists can produce accurate benthic cover estimates of key coral groups. The deep learning and citizen scientist analysis methods had different but complementary strengths depending on coral category. When the best performing analysis method was used for each category in all images, mean estimates from 8086 images of percent benthic cover of branching Acropora, plating Acropora, and massive-form coral were ~ 99% accurate compared to expert assessment, and > 95% accurate at all coral cover ranges tested. Site-level accuracy of 95% was attainable with 18-80 images. Power analyses showed that up to 114 images per site were needed to detect a 10% absolute difference in coral cover per category (power = 0.8). However, estimates of 'all other coral' as a single category achieved 95% accuracy at only 60% of sites and for images with 10-30% coral cover. Overall, emerging technology and citizen science present an attainable tool for collecting inexpensive, widespread data that can complement higher resolution survey programs or be an accessible tool for locations with limited scientific or conservation resources.</p>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 7","pages":"814"},"PeriodicalIF":2.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piper Kadsura Extract and its Bioactive Components Attenuates Aβ_25-35-Induced Neurotoxicity by Modulating Glycolysis and Activating the SIRT1/PPARγ/GLUT1 Axis.","authors":"Kaili Ye, Mengnan Zeng, Beibei Zhang, Fengxiao Hao, Pengli Guo, Yuhan Zhang, Tong Liu, Hui Chen, Weisheng Feng, Xiaoke Zheng","doi":"10.1007/s11064-025-04433-8","DOIUrl":"https://doi.org/10.1007/s11064-025-04433-8","url":null,"abstract":"<p><p>Piper kadsura (Choisy) Ohwi, a traditional medicinal plant used in East Asia, is renowned for its anti-inflammatory and antioxidant properties. Its bioactive components, such as Hancinone and Futoquinol, show potential in treating neurodegenerative disorders like Alzheimer's disease (AD). Aim of the study: This study investigates the neuroprotective effects of Piper kadsura extract (PK) and its active components, Hancinone (C1) and Futoquinol (C2), in Aβ_25-35-induced AD models. PK, C1, and C2 were evaluated in Aβ_25-35-induced PC-12 and N9 cells, as well as a mouse model of AD. Cellular assays, Seahorse analysis, and molecular docking were used to explore glycolysis, oxidative stress, and apoptosis. Gut microbiota composition was analyzed via 16 S rDNA sequencing. PK, C1, and C2 significantly improved cell viability, restored glycolysis, and reduced oxidative stress by activating the SIRT1/PPARγ/GLUT1 pathway. PK also alleviated neuronal damage and enhanced cognitive performance in mice. Gut microbiota analysis revealed increased beneficial bacteria (e.g., Lactobacillus) and enriched glycolysis-related pathways. Piper kadsura and its components exhibit multifaceted neuroprotective effects by modulating energy metabolism, reducing oxidative stress, and regulating the gut-brain axis. These findings support the therapeutic potential of Piper kadsura in AD treatment.</p>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"50 4","pages":"216"},"PeriodicalIF":3.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the binding mechanism of 1,4-bis[(3-Piperidino)propanamido]anthracen-9,10-dione (1,4-BPAQ) to human telomeric G-quadruplexes: a multi-technique approach including spectroscopic, calorimetric and molecular docking insights.","authors":"Priya Kumari, Kumud Pandav, Anuradha Panwar, Shrikant Kukreti, Mala Nath, Ritu Barthwal, Surat Kumar","doi":"10.1007/s10822-025-00615-2","DOIUrl":"https://doi.org/10.1007/s10822-025-00615-2","url":null,"abstract":"<p><p>Current research suggests that anthraquinone compounds have ability to interact with G4 DNA, leading to its stabilization and potential use as telomerase inhibitors in human cells. In light of this, a series of experiments to investigate the interaction between the compound 1,4-bis[(3-Piperidino)propanamido]anthracen-9,10-dione (1,4-BPAQ) and human telomeric DNA sequences in solutions rich in K⁺ and Na⁺ solutions was conducted. Employing various biophysical techniques and titration studies, it was observed that the binding of 1,4-BPAQ to G4 sequences resulted in notable changes in absorbance, including hypochromicity followed by hyperchromicity. Furthermore, extensive fluorescence quenching (94%) was accompanied by shifts in absorbance maxima, emission wavelength, and change in ellipticity (at 265 nm and 290 nm) was found in CD spectra. The data analysis indicated possible stoichiometries of 0.5:1 and 1:1 for the drug-quadruplex DNA complexes. Presence of a red shift suggested partial stacking between bases as primary interaction mode. Interestingly, binding affinity values were moderately higher in K⁺-rich solution. In addition, a significant thermal stabilization effect of up to 25 °C in K⁺ environment, while no such stabilization was observed in Na⁺ solution upon ligand binding. Molecular docking studies revealed similar binding energies across all conformational variations, despite distinct contact patterns between the ligand and three different G4 DNA conformations (2HY9/2JPZ/143D). This research demonstrated the potential anticancer activity of 1,4-BPAQ through MTT assay, with apoptosis activity observed at lower concentrations (IC₅₀ = 5.25 µM) against HepG2 cancer cells. These structural findings may hold significance in the context of drug development for anti-cancer therapies.</p>","PeriodicalId":621,"journal":{"name":"Journal of Computer-Aided Molecular Design","volume":"39 1","pages":"37"},"PeriodicalIF":3.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranberry extract attenuates indomethacin-induced gastriculcer in rats via its potential atioxidant and anti-inflammatory effects.","authors":"Zaid Mahmood Abdul-Majeed, Mohammed Qasim Yahya Malallah A Al-Atrakji, Hayder Ridha-Salman","doi":"10.1007/s10735-025-10438-y","DOIUrl":"https://doi.org/10.1007/s10735-025-10438-y","url":null,"abstract":"<p><p>Indomethacin (IND) belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed for the treatment of rheumatoid diseases and linked to the development of gastric ulcers in many people. Cranberry is a rich source of polyphenols and flavonoids, which have powerful antioxidant and anti-inflammatory properties. The study aimed to evaluate the activity of cranberry aqueous extract on IND-induced gastric ulcers in albino rats. Twenty adult male rats were sequentially assigned to four groups of five each. The control group consumes distilled water (DW) orally for 15 days. The IND group received a single oral dosage (60 mg/kg) of IND. The omeprazole (OMP) group got 60 mg/kg of IND as a single oral dose and then 20 mg/kg/day of OMP for 15 days. The cranberry group was given a single dose of IND 60 mg/kg orally and 200 mg/kg/day of cranberry aqueous extract for 15 days. Rats were euthanized on day 16, and gastric tissues were removed for biochemical and histopathological evaluations. Cranberry extract considerably ameliorated the severity of IND-induced gastric ulcerations and fixed the histopathological alterations, including mucosal membrane necrosis, congestion, inflammatory cell penetration, and deteriorations of GIT. Furthermore, IND-exposed rats treated with cranberry extract exhibited dramatically lower serum levels of oxidative biomarkers like MDA and inflammatory biomarkers like TNF-α and IL-6, but higher levels of anti-oxidative biomarkers like SOD and GPx and anti-inflammatory biomarkers like IL-10. The bioactive flavonoids and polyphenols content of cranberry extract could account for its profound gastroprotective effects. The anti-oxidative and anti-inflammatory properties of cranberry extract could be a promising strategy for ameliorating the IND-aggravated gastrotoxicity.</p>","PeriodicalId":650,"journal":{"name":"Journal of Molecular Histology","volume":"56 4","pages":"206"},"PeriodicalIF":2.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational design of fused-ring-modified rhodamine chemosensors for salicylic acid detection: its mechanistic insights and biological application.","authors":"Mei-Hong Ge, A-Ling Tang, Feng Gao, Shuai Tan, Wei Niu, Xiang Zhou, Song Yang","doi":"10.1007/s11030-025-11261-z","DOIUrl":"https://doi.org/10.1007/s11030-025-11261-z","url":null,"abstract":"<p><p>Salicylic acid (SA) functions as a critical phytohormone coordinating developmental regulation and defense responses in plants. Understanding SA's regulatory roles in both homeostasis and stress adaptation necessitates advanced monitoring platforms. We designed six rhodamine probes (R1-R6) containing spirolactam or spirohydrazone bridges to systematically evaluate five-membered spiro structures for SA detection. Furthermore, through Fourier infrared experiments (FTIR) and density functional theory (DFT) calculations, we performed molecular orbital analysis to disclose the SA-responsive mechanism underlying the rhodamine ring-opening process induced by SA. Comparative analysis revealed that spirohydrazone-modified probes displayed enhanced fluorescence performance and improved molecular recognition specificity for SA. The optimized probe R2, incorporating a quinoline moiety, achieved exceptional sensing performance through synergistic hydrogen bonding and C-H…π interactions, demonstrating high selectivity, rapid response kinetics (< 30 s), and excellent sensitivity (LOD = 0.87 μM). Overall, this study successfully visualized endogenous SA distribution in living tomato root systems, establishing a novel design framework for acylhydrazone-based rhodamine sensors and elucidating the SA response mechanism through molecular dynamics simulations.</p>","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass spectrometry-based spatiotemporal characterization of lipids in early focal cerebral ischemia.","authors":"Weifeng Li, Tengrui Shi, Zijun Liao, Yuan Zhang, Wenlan Liu","doi":"10.1007/s00216-025-05981-2","DOIUrl":"https://doi.org/10.1007/s00216-025-05981-2","url":null,"abstract":"<p><p>Understanding spatial lipid alterations in the brain during the hyper-acute phase of acute ischemic stroke (AIS) is crucial for elucidating the underlying mechanisms of disease progression and therapeutic response. In this study, we employed an integrated approach combining matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and pseudo-targeted lipidomics to characterize lipid changes in the mice brain after 1 h, 2 h, and 3 h of middle cerebral artery occlusion (MCAO). Remarkably, MALDI-MSI detected significant lipid alterations in ischemic brain regions as early as 1 h post-MCAO, preceding visible tissue infarction by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Lipidomics analysis further revealed region-specific lipid alterations at this early time point, suggesting that lipid profiles may serve as more sensitive biomarkers of ischemic brain injury than conventional histopathological methods. Notably, both MSI and lipidomics analysis demonstrated consistent temporal progression of lipid changes. Significantly altered lipids exhibited a nearly identical increasing trend with prolonged ischemic duration, with the ischemic cortex showing the most pronounced lipid dysregulation. In conclusion, our findings demonstrate that MALDI-MSI coupled with lipidomics provides a comprehensive platform for mapping the dynamic lipid landscape in the ischemic brain during early AIS, with observed patterns well correlating with the expansion of tissue infarction.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}