Analytical Methods最新文献

Electrochemical determination of captopril using disposable graphite electrode modified with a molecularly imprinted film, accompanied by a ratiometric read-out 使用分子印迹薄膜修饰的一次性石墨电极电化学测定卡托普利，并伴有比率读出器

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-13 DOI: 10.1039/d4ay00724g

Mohamed Mohamoud El-Wekil, Khalid Alhazzani, Al-Montaser Bellah H. Ali, Alanazi AZ, Hossieny Ibrahim, Mahmoud Darweesh

{"title":"Electrochemical determination of captopril using disposable graphite electrode modified with a molecularly imprinted film, accompanied by a ratiometric read-out","authors":"Mohamed Mohamoud El-Wekil, Khalid Alhazzani, Al-Montaser Bellah H. Ali, Alanazi AZ, Hossieny Ibrahim, Mahmoud Darweesh","doi":"10.1039/d4ay00724g","DOIUrl":"https://doi.org/10.1039/d4ay00724g","url":null,"abstract":"In this research paper, a novel \"signal on-off\" ratiometric-based electrochemical platform was developed for the sensitive and selective detection of captopril. Ratiometric responses were achieved by fabricating molecularly-imprinted polymers (MIPs) on the surface of a graphite electrode (GE) decorated with nitrogen (N) and sulfur (S) co-doped porous carbon and silver nanoparticles (Ag). The MIP layer was formed via electropolymerization of copper coordinated with pyrrole-3-carboxylic acid (functional monomer). Silver nanoparticles (Ag) were incorporated to enhance conductivity, surface area, and to serve as an internal reference output. Upon the addition of captopril, there was a decrease in the anodic oxidation current of Ag+ at around 0.067 V, coupled with an increase in the oxidation current at 0.54 V (Ag-captopril complex). Under optimized conditions, the electrochemical responses (IAg-captopril/IAg) increased linearly with increasing captopril concentration in the range of 1-450 nM, with a detection limit (S/N=3) of 0.3 nM. The ratiometric-based MIP electrochemical platform (Cu-MIP/NS-PC@Ag/GE) was successfully applied to detect captopril in complex matrices such as tablets, serum, and urine samples. This platform holds promise for sensitive and selective detection of captopril in various practical applications.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A machine learning-driven SERS platform for precise detection and analysis of vascular calcification 用于精确检测和分析血管钙化的机器学习驱动型 SERS 平台

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-12 DOI: 10.1039/d4ay01061b

Wei Li, Zhilian You, Dawei Cao, Naifeng Liu

{"title":"A machine learning-driven SERS platform for precise detection and analysis of vascular calcification","authors":"Wei Li, Zhilian You, Dawei Cao, Naifeng Liu","doi":"10.1039/d4ay01061b","DOIUrl":"https://doi.org/10.1039/d4ay01061b","url":null,"abstract":"Vascular calcification (VC) significantly increases the incidence and mortality rates of cardiovascular diseases, severely threatening public health as a global issue. Currently, there are no effective methods to prevent and treat vascular calcification. This study proposes a machine learning-assisted surface-enhanced Raman scattering (SERS) technique for label-free, highly sensitive analysis of VC rat serum. We prepared gold nanobipyramid (GNBP) substrates using seed-mediated and liquid–liquid interface self-assembly methods and measured the SERS spectra of the serum. The collected spectral data were processed using a Principal Component Analysis (PCA)-Linear Discriminant Analysis (LDA) model to achieve effective sample differentiation. In this analysis model, GNBP substrates enabled rapid, sensitive, and label-free serum spectral detection, achieving classification accuracy, sensitivity, and specificity of 96.0%, and an AUC value of 0.98, significantly outperforming currently used machine learning methods. By analyzing the PCA loading plots, key spectral features that distinguished VC were successfully captured. This study demonstrates that combining SERS technology with machine learning provides a new method and foundation for real-time diagnosis and identification of VC, showcasing the significant advantages of GNBP substrates in high-sensitivity and high-specificity detection, potentially improving the early diagnosis and treatment of VC significantly.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel and useful methodology for the simultaneous analysis of multiclass contaminants in bovine fat 开发一种新颖实用的方法，用于同时分析牛脂肪中的多类污染物

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-12 DOI: 10.1039/d4ay00516c

Rodrigo Souza, Natalia Gérez García, Natalia Besil, Maria Veronica Cesio, Horacio Heinzen, Maria Lucia Pareja

{"title":"Development of a novel and useful methodology for the simultaneous analysis of multiclass contaminants in bovine fat","authors":"Rodrigo Souza, Natalia Gérez García, Natalia Besil, Maria Veronica Cesio, Horacio Heinzen, Maria Lucia Pareja","doi":"10.1039/d4ay00516c","DOIUrl":"https://doi.org/10.1039/d4ay00516c","url":null,"abstract":"The instrumental development of tandem mass spectrometers fosters the actual trend in the trace analysis of organic compounds to the development of methods that allow the analysis of contaminants of the most diverse origin in a single analytical sample. The multiclass methods are aligned with the Who´s One Health initiative while accomplishing the concepts of green chemistry. However, there are few reports of wide scope multiclass methods for the analysis of contaminants in this matrix. In this work, a method for the simultaneous determination of 62 compounds in bovine fat, was developed and validated following DG-SANTE/11813/2021 guidance. Liquid nitrogen milled fat was extracted with toluene and acetonitrile. Then a clean-up in a cryogenic bath, followed by dispersive solid phase extraction was performed. Residue determination was done using liquid chromatography for 44 compounds and gas chromatography for 18 compounds, both coupled to tandem mass spectrometry in MRM mode. The method was first developed and validated for two ectoparasiticides, then the scope was expanded for the analysis of 13 veterinary drugs and 49 pesticides. Recovery percentages were in the range of 60-134%, high matrix effect was observed in 50% of the scope of the method. Most compounds presented limits of quantification of 10 µg kg-1 in compliance with international requirements. The method was applied to monitor 49 commercial samples to evaluate its performance. Eighty percent of samples contained ethion and 10% had fluazuron, both within MRLs, highlighting the need for proper withdrawal times.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indirect detection of lead(II), cadmium(II) and mercury(II) on a microfluidic electrophoresis chip 在微流控电泳芯片上间接检测铅(II)、镉(II)和汞(II)

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-12 DOI: 10.1039/d4ay01174k

Shuai Yuan

{"title":"Indirect detection of lead(II), cadmium(II) and mercury(II) on a microfluidic electrophoresis chip","authors":"Shuai Yuan","doi":"10.1039/d4ay01174k","DOIUrl":"https://doi.org/10.1039/d4ay01174k","url":null,"abstract":"Water environments contaminated by heavy metal ions present significant challenges because these pollutants do not degrade naturally, leading to their gradual bioaccumulation in animals and plants, which ultimately poses an insurmountable threat to human health. Therefore, rapid and accurate detection of heavy metal ions in water is of great significance for environmental protection and disease prevention. In this work, we developed a novel method based on microfluidic electrophoresis coupled with indirect chemiluminescence for the immediate detection of Cd(II), Pb(II) and Hg(II) heavy metal ions. The displacement of the Co(II) ions within the chemiluminescence mixture by the above migrating sample cations caused a measurable reduction in the background signal. The results showed that the detection limits of Cd(II), Pb(II) and Hg(II) ions under the best detection conditions were 5.83 × 10−8 M, 5.38 × 10−8 M and 2.09 × 10−8 M, respectively, which were 1–2 orders of magnitude lower than those of the indirect UV method and 1 order of magnitude lower than that of the indirect laser induced detection method. This method can provide a possibility for the rapid detection of multiple heavy metal ions in actual water environments.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Preparation of Fluorescence Dual-Modality Nanosensor for Discrimination and Determination of Biothiols in Real Sample and Its Practical Detection Kit 用于鉴别和检测实际样品中生物硫醇的荧光双模态纳米传感器的制备及其实用检测试剂盒

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-12 DOI: 10.1039/d4ay01025f

İpek Ömeroğlu, VİLDAN ŞANKO, Ahmet Şenocak, Süreyya Oğuz Tümay

{"title":"The Preparation of Fluorescence Dual-Modality Nanosensor for Discrimination and Determination of Biothiols in Real Sample and Its Practical Detection Kit","authors":"İpek Ömeroğlu, VİLDAN ŞANKO, Ahmet Şenocak, Süreyya Oğuz Tümay","doi":"10.1039/d4ay01025f","DOIUrl":"https://doi.org/10.1039/d4ay01025f","url":null,"abstract":"Biothiols widely exist in living organisms and have a crucial function in the human body for maintaining redox balance. It is vital yet difficult to develop probes that can detect and distinguish biothiols at the same time. This study presented the use of a very sensitive dual-modality nanosensor, NBD-Nap@NCC, for the discrimination and determination of biothiols in the real sample and its practical application based on RGB analysis by smartphone. The sensitive nanosensor was successfully prepared by surface modification of nanocrystalline cellulose (NCC), combining NBD and naphthalene fluorophores. Due to the high electron-withdrawing behavior of the NBD group which led to the PET mechanism between fluorophores, the prepared NBD-Nap@NCC nanosensor has a very weak fluorescence response. After treatment with Hcy or Cys, NBD-Nap@NCC quickly provided remarkably and in different rates of fluorescence “turn-on” response in both the blue and green channels, which was attributable to naphthalene and NBD fluorophores as a result of inhibition of PET mechanism. However, after treatment with GSH, only a significant blue-channel emission that was attributed to naphthalene fluorophore was obtained, indicating the inhibition of the PET mechanism. Furthermore, the NCC platform improves sensitivity and selectivity by increasing surface area and the number of binding sites due to modification of the NBD group on the surface. The detection limit ranged between 0.910 to 1.150 mol.L-1 for biothiols with large dynamic response ranges. The quantity of the Hcy, Cys and GSH were successfully determined in real sample after the evaluation of accuracy by HPLC and spike/recovery analysis. Additionally, paper-based analysis kits were fabricated for the practical detection of biothiols by RGB changes which were determined via the smartphone application.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polar viscosity-sensitive fluorescent probe with large Stokes shifts for simultaneous imaging of lipid droplets and lysosomes in tobacco leaf vein cells and biological systems 具有大斯托克斯位移的极性粘度敏感荧光探针，用于同时成像烟草叶脉细胞和生物系统中的脂滴和溶酶体

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-12 DOI: 10.1039/d4ay01671h

Yuan He, Zhi-Hao Zhang, Long-Ke Li, Xun Ji, Guo-Yu Chen, Jian-Yong Wang

{"title":"A polar viscosity-sensitive fluorescent probe with large Stokes shifts for simultaneous imaging of lipid droplets and lysosomes in tobacco leaf vein cells and biological systems","authors":"Yuan He, Zhi-Hao Zhang, Long-Ke Li, Xun Ji, Guo-Yu Chen, Jian-Yong Wang","doi":"10.1039/d4ay01671h","DOIUrl":"https://doi.org/10.1039/d4ay01671h","url":null,"abstract":"Lipid droplets (LDs) and lysosomes were dynamic organelles present in most eukaryotic cells that were interconnected and worked closely together to ensure the smooth physiological activities of organisms. The interaction between lipid droplets and lysosomes was thought to play a role in the development of certain diseases. The polarity in different organelles may exhibit variations. Real-time monitoring of abnormal changes in polarity in lipid droplets and lysosomes was therefore of practical importance in understanding the mechanisms that lead to these diseases. The Nap-Lyso-Ph-OH probe was constructed according to the ICT mechanism and exhibited sensitivity to both polarity and viscosity. The probe exhibited low cytotoxicity, a large Stokes shift, excellent selectivity and photostability. The probe was successfully used for labelling and imaging of lipid droplets and lysosomes in imaging cells and zebrafish. Interestingly, we used tobacco seedling cells to explore the ability of Nap-Lyso-Ph-OH for imaging lipid droplet labelling in plant cells.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discrimination of serum samples of prostate cancer and benign prostatic hyperplasia with 1H-NMR metabolomics 利用 1H-NMR 代谢组学鉴别前列腺癌和良性前列腺增生的血清样本

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-12 DOI: 10.1039/d4ay01109k

Mohammed Zniber, Parastoo Vahdatiyekta, Tan-Phat Huynh

{"title":"Discrimination of serum samples of prostate cancer and benign prostatic hyperplasia with 1H-NMR metabolomics","authors":"Mohammed Zniber, Parastoo Vahdatiyekta, Tan-Phat Huynh","doi":"10.1039/d4ay01109k","DOIUrl":"https://doi.org/10.1039/d4ay01109k","url":null,"abstract":"Prostate cancer continues to be a prominent health concern for men globally. Current screening techniques, primarily the prostate-specific antigen (PSA) test and digital rectal examination (DRE), possess inherent limitations, with prostate biopsy being the definitive diagnostic procedure. The invasive nature of the biopsy and other drawbacks of current screening tests highlight the need for non-invasive and more accurate diagnostic methods. This study utilized 1H-NMR (Nuclear Magnetic Resonance) based serum metabolomics to differentiate between prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Serum samples from 40 PCa and 41 BPH patients were analysed using 1H-NMR spectroscopy. PepsNMR was utilized for preprocessing the raw NMR data, and the binned spectra were examined for patterns distinguishing PCa and BPH. Principal component analysis (PCA) showed a moderate separation between PCa and BPH, highlighting the distinct metabolic profiles of both conditions. Furthermore, a logistic regression model was developed, which demonstrated good performance in distinguishing between the two conditions. The results showed significant variance in multiple metabolites between PCa and BPH, such as isovaleric acid, ethylmalonic acid, formate, and glutamic acid. This research underlines the potential of 1H-NMR-based serum metabolomics as a promising tool for improved prostate cancer screening, offering an alternative to the limitations of current screening methods.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous boron-doped graphitic carbon nitride-based label-free electrochemical immunoassay of vascular endothelial cadherin 基于多孔掺硼石墨氮化碳的血管内皮凝集素无标记电化学免疫分析法

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-11 DOI: 10.1039/d4ay01112k

Xuan Wang, Mengting He, Rujie Yu, Liang Tan

{"title":"Porous boron-doped graphitic carbon nitride-based label-free electrochemical immunoassay of vascular endothelial cadherin","authors":"Xuan Wang, Mengting He, Rujie Yu, Liang Tan","doi":"10.1039/d4ay01112k","DOIUrl":"https://doi.org/10.1039/d4ay01112k","url":null,"abstract":"As a main connecting protein between endothelial cells, vascular endothelial cadherin (CD144) is involved in regulating vascular remodeling and maintaining vascular integrity. It is regarded as a marker of endothelial dysfunction and injury. Quantitative determination of CD144 is of importance in the pathology research, diagnosis and treatment of vascular diseases. A label-free electrochemical method for the immunoassay of CD144 was developed in this work. CD144 antibodies was assembled on glassy carbon electrode modified with porous boron-doped carbon nitride (B-GCN) and gold nanoparticles (AuNPs) in the presence of protein A. The binding of CD144 on the antibody-modified electrode induced serious steric hindrance, inhibiting the diffusion of ferri-/ferrocyanide from the bulk electrolyte to the electrode interface. The change of the differential pulse voltammetric response displayed a linear relationship with the concentration of CD144 between 0.500 and 400 ng mL-1. The new electrochemical sensor showed some good performances including good selectivity, high stability and satisfactory reproducibility. The cellular morphology observation and activity measurement showed that the dysfunction of vascular endothelial cells appeared in the presence of high-content NaCl. The electrochemical analysis reveals a positive correlation between the release amount of CD144 from the dysfunctional cells and the NaCl concentration in the growth medium.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Sensitive, Rapid and Cost-Effective RP-HPLC-UV Method for Detection and Quantification of Bedaquiline in Physiological fluid (pH 7.4). 一种灵敏、快速、经济高效的 RP-HPLC-UV 方法，用于检测和定量生理液（pH 值为 7.4）中的贝达喹啉。

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-11 DOI: 10.1039/d4ay01143k

Simisola Ayodele, Armorel Van Eyk, Pradeep Kumar, Yahya Essop Choonara

{"title":"A Sensitive, Rapid and Cost-Effective RP-HPLC-UV Method for Detection and Quantification of Bedaquiline in Physiological fluid (pH 7.4).","authors":"Simisola Ayodele, Armorel Van Eyk, Pradeep Kumar, Yahya Essop Choonara","doi":"10.1039/d4ay01143k","DOIUrl":"https://doi.org/10.1039/d4ay01143k","url":null,"abstract":"Bedaquiline, a highly lipophilic molecule, is used in the treatment regimen of multi-drug resistant tuberculosis. A rare complication of pulmonary tuberculosis is tuberculous pericarditis. Ex vivo studies utilizing animal pericardium can be used to investigate whether this drug is capable of diffusing across pericardial tissue into simulated pericardial fluid (pH 7.4) to indicate efficacy. For detection of bedaquiline in physiological fluid, a rapid, cost-effective and sensitive method is essential. The aim of this study was thus to develop and validate a simple and sensitive RP-HPLC-UV method for the detection and quantification of bedaquiline, encapsulated in a nanosystem, at pH 7.4 after permeation across excised pericardium. A HPLC Phenomenex Kinetex RPC18 column (150 x 4.6 mm, 5 µm) was utilized for analysis. The mobile phase consisted of 95:5 v/v (A: B), where (A) Methanol: Acetonitrile (85:15 v/v): (B) Triethylamine (1% v/v):0.15 mM KH2PO4 buffer (pH 7.4). Running conditions included the following: injection volume 20 µl, flow rate 1.0 ml.min-1, detection wavelength 275 nm, 25oC and running time of 5 min. Bedaquiline eluted as a single symmetrical peak at a retention time of 4.17 min. The method was found to be linear within the range of 1 - 50 μg.ml-1 (R2 = 1). The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.05 μg.ml-1 and 0.15 μg.ml-1, respectively (signal-to-noise ratio method). All validation parameters were found to be within acceptable limits (RSD<2%). The method was fast, reliable, accurate, reproducible, and transient for the detection of bedaquiline in simulated physiological fluid (pH 7.4). This method can thus be applied to easily detect bedaquiline in body fluids (pH 7.4) i.e. blood and pericardial fluid without the accuracy being impacted by ionization factors of the molecule.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photochemical degradation of antibiotics: real-time investigation by aerodynamic thermal breakup droplet ionization mass spectrometry 抗生素的光化学降解：空气动力热破裂液滴电离质谱法的实时研究

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-11 DOI: 10.1039/d4ay01459f

Dmitriy G. Sheven, Viktor Pervukhin

引用次数: 0