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Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice 螺旋乳杆菌通过调节小鼠肠道微生态减轻酒精性肝损伤
IF 5.7 2区 生物学
Microbial Biotechnology Pub Date : 2024-10-21 DOI: 10.1111/1751-7915.70016
Jiawen Lv, Guanjing Lang, Qiangqiang Wang, Wenlong Zhao, Ding Shi, Ziyuan Zhou, Yangfan Shen, He Xia, Shengyi Han, Lanjuan Li
{"title":"Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice","authors":"Jiawen Lv,&nbsp;Guanjing Lang,&nbsp;Qiangqiang Wang,&nbsp;Wenlong Zhao,&nbsp;Ding Shi,&nbsp;Ziyuan Zhou,&nbsp;Yangfan Shen,&nbsp;He Xia,&nbsp;Shengyi Han,&nbsp;Lanjuan Li","doi":"10.1111/1751-7915.70016","DOIUrl":"https://doi.org/10.1111/1751-7915.70016","url":null,"abstract":"<p>Previous reports have demonstrated that alcohol consumption significantly reduces the abundance of <i>Lactobacillus</i> in the gut. In this study, we selected five species of the genus <i>Lactobacillus</i>, commonly found in fermented foods, and acknowledged them as safe, edible, and effective in preventing or treating certain diseases, to evaluate their effects on alcoholic liver disease (ALD). By comparing the liver damage indices in each group, we found that the type strain of <i>Lactobacillus helveticus</i> (LH, ATCC 15009) had the most marked alleviating effect on ALD-induced liver injury. Furthermore, experiments combining microbiomics and metabolomics were conducted to explore the mechanisms underlying the hepatoprotective effects of LH. Finally, we discovered that LH mitigated ethanol-induced liver steatosis and inflammation in ALD mice by altering the structure and function of the gut microbiome, increasing intestinal levels of short-chain fatty acids (SCFAs), and enhancing gut barrier integrity. These findings suggest a potential strategy for the clinical management of patients with ALD.</p>","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Potential Application of Mung Bean (Vigna radiata L.) Protein in Plant-Based Food Analogs: A Review 绿豆(Vigna radiata L.)蛋白在植物基食品模拟物中的潜在应用:综述
Legume Science Pub Date : 2024-10-20 DOI: 10.1002/leg3.70011
Mohammad Tarahi
{"title":"The Potential Application of Mung Bean (Vigna radiata L.) Protein in Plant-Based Food Analogs: A Review","authors":"Mohammad Tarahi","doi":"10.1002/leg3.70011","DOIUrl":"https://doi.org/10.1002/leg3.70011","url":null,"abstract":"<p>The increasing demand for plant-based food products by consumers along with the growing global population requires the discovery of novel and sustainable protein sources to address environmental challenges and meet nutritional requirements. Among various plant proteins, mung bean protein (MBP) exhibits several unique characteristics that make it a valuable ingredient in the field of plant-based food analogs. This literature review aims to express the unique structure and composition of MBP, in addition to its physicochemical, functional, and nutritional properties. Furthermore, its potential applications in novel meat, dairy, and egg analogs are highlighted to meet the growing demand for sustainable, nutritious, and delicious plant-based food alternatives. Structurally, MBP consists of a complex arrangement of amino acids, forming a globular protein with distinct functional properties. Its composition is also rich in essential amino acids, particularly leucine and lysine, making it a promising protein source for plant-based diets. From a techno-functional perspective, MBP exhibits remarkable gelling, emulsifying, foaming, and binding properties, which are necessary for the development of stable emulsions, airy foams, firm gels, and cohesive textures in various plant-based food formulations. Moreover, MBP and its derivatives can possess notable bio-functional properties, including antioxidant activity and anti-inflammatory benefits, as well as cholesterol-lowering, anti-obesity, antidiabetic, antihypertensive, and anticancer effects. Consequently, the production of food analogs based on MBP not only improves the techno-functional attributes of the final products but also can promote consumer health and well-being.</p>","PeriodicalId":17929,"journal":{"name":"Legume Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/leg3.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cooking Time, Seed Darkening, and Iron and Zinc Concentrations of Selected Andean Genotypes of Common Bean 部分安第斯蚕豆基因型的蒸煮时间、种子变黑及铁和锌浓度
Legume Science Pub Date : 2024-10-20 DOI: 10.1002/leg3.70012
Swivia Hamabwe, Kuwabo Kuwabo, Carlos Urrea, Karen Cichy, Kelvin Kamfwa
{"title":"Cooking Time, Seed Darkening, and Iron and Zinc Concentrations of Selected Andean Genotypes of Common Bean","authors":"Swivia Hamabwe,&nbsp;Kuwabo Kuwabo,&nbsp;Carlos Urrea,&nbsp;Karen Cichy,&nbsp;Kelvin Kamfwa","doi":"10.1002/leg3.70012","DOIUrl":"https://doi.org/10.1002/leg3.70012","url":null,"abstract":"<p>Cooking time (CT), post-harvest darkening (PHD), and micronutrient content influence consumer preference of common bean (<i>Phaseolus vulgaris</i> L.) varieties. The objective of this study was to evaluate Andean genotypes for CT, PHD, and seed iron and zinc concentration. A total of 52 genotypes belonging to three market classes, namely, purple-speckled (Kabulangeti), yellows, and cranberry (sugar beans), were grown at the Golden Valley Agricultural Research Trust (GART) Farm and the Mpika Research Farm in Zambia and assessed for CT, PHD, and seed iron and zinc concentration. The fastest cooking genotype among all 52 genotypes was a yellow genotype, Y1612-5. Yellow genotypes generally cooked faster than the Kabulangeti and sugar types. Among the elite lines with Kabulangeti seed types, which is a dominant market class in Zambia, the elite line K175 had faster CT and higher iron and zinc concentration than the Kabulangeti landrace race currently available on the Zambian market. Kabulangeti and sugar genotypes showed regular darkening, whereas yellows did not darken. The yellow genotype Y1612-3 was particularly outstanding because of its unique combination of high concentrations of both iron and zinc. Therefore, it can be used to introgress these two essential minerals into variable genetic backgrounds. The significant variability and high to moderate heritability for CT (0.85) and iron (0.81) and zinc (0.58) concentration observed in the current study suggest that it is possible to make progress in breeding for faster cooking varieties that are rich in iron and zinc.</p>","PeriodicalId":17929,"journal":{"name":"Legume Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/leg3.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Antenna Place Codes for Reducing Sidelobes of SIAR and Frequency Diverse Array Sensors 天线位置编码对减少 SIAR 和频率多样化阵列传感器侧摆的影响
IF 1.1 4区 工程技术
IET Signal Processing Pub Date : 2024-10-20 DOI: 10.1049/2024/9458494
Pourya Yaghoubi Aliabad, Hossein Soleimani, Mohammad Soleimani
{"title":"The Effect of Antenna Place Codes for Reducing Sidelobes of SIAR and Frequency Diverse Array Sensors","authors":"Pourya Yaghoubi Aliabad,&nbsp;Hossein Soleimani,&nbsp;Mohammad Soleimani","doi":"10.1049/2024/9458494","DOIUrl":"https://doi.org/10.1049/2024/9458494","url":null,"abstract":"<div>\u0000 <p>Synthetic impulse and aperture radar (SIAR) is a technique that frequency diverse array (FDA) radars can imply in practice, thus overcoming some of their challenges. SIAR radars, used in various fields like transportation and defense, can detect the range, azimuth angle, elevation angle, and Doppler of the target with their 4D-matched filter and a single receiver. However, the challenge of high-amplitude sidelobes is a significant concern for researchers. They have attempted to reduce it through various approaches, including frequency code, range–angle coupling, and range–Doppler coupling, to accurately identify target characteristics. This paper presents the antenna place code (AP code) parameter as a significant factor in minimizing sidelobe amplitudes. The parameter specifies that, rather than having all antennas active, a certain number of antennas are active in each pulse repetition interval (PRI) to achieve a lower sidelobe. Researchers have found that using AP codes can effectively lower the amplitude of the range–angle sidelobe, the range–Doppler sidelobe, error coupling, the repetition of sidelobe strands, and the output of angle error for different target angles. All studies are conducted on a linear array for simplicity. The output of various AP codes is compared to the previously common uniform array.</p>\u0000 </div>","PeriodicalId":56301,"journal":{"name":"IET Signal Processing","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/2024/9458494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Ecosystem Nitrogen Cycling Reciprocates Between Land-Use Conversion and Its Reversal 全球生态系统氮循环在土地利用转换和逆转之间相互影响
IF 10.8 1区 环境科学与生态学
Global Change Biology Pub Date : 2024-10-19 DOI: 10.1111/gcb.17537
Yves Uwiragiye, Jing Wang, Yuanyuan Huang, Liangping Wu, Jiake Zhou, Yanhui Zhang, Meiqi Chen, Hang Jing, Yinfei Qian, Ahmed S. Elrys, Yi Cheng, Zucong Cai, Minggang Xu, Scott X. Chang, Christoph Müller
{"title":"Global Ecosystem Nitrogen Cycling Reciprocates Between Land-Use Conversion and Its Reversal","authors":"Yves Uwiragiye,&nbsp;Jing Wang,&nbsp;Yuanyuan Huang,&nbsp;Liangping Wu,&nbsp;Jiake Zhou,&nbsp;Yanhui Zhang,&nbsp;Meiqi Chen,&nbsp;Hang Jing,&nbsp;Yinfei Qian,&nbsp;Ahmed S. Elrys,&nbsp;Yi Cheng,&nbsp;Zucong Cai,&nbsp;Minggang Xu,&nbsp;Scott X. Chang,&nbsp;Christoph Müller","doi":"10.1111/gcb.17537","DOIUrl":"https://doi.org/10.1111/gcb.17537","url":null,"abstract":"<div>\u0000 \u0000 <p>Anthropogenic land-use practices influence ecosystem functions and the environment. Yet, the effect of global land-use change on ecosystem nitrogen (N) cycling remains unquantified despite that ecosystem N cycling plays a critical role in maintaining food security. Here, we analysed 2430 paired observations globally to show that converting natural to managed ecosystems increases ratios of autotrophic nitrification to ammonium immobilisation and nitrate to ammonium, but decreases soil immobilisation of mineral N, causing increased N losses via leaching and gaseous N emissions, such as nitrous oxide (e.g., via denitrification), resulting in a leaky N cycle. Changing land use from intensively managed to one that resembles natural ecosystems reversed N losses by 108% on average, resulting in a more conservative N cycle. Structural equation modelling revealed that changes in soil organic carbon, pH and carbon to N ratio were more important than changes in soil moisture content and temperature in predicting ecosystem N retention capacities following land-use conversion and its reversion. The hotspots of leaky N cycles were mostly in equatorial and tropical regions, as well as in Western Europe, the United States and China. Our results suggest that whether an ecosystem exhibits a conservative N cycle after land-use reversion depends on management practices.</p>\u0000 </div>","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inorganic Carbon Pools and Their Drivers in Grassland and Desert Soils 草地和沙漠土壤中的无机碳库及其驱动因素
IF 10.8 1区 环境科学与生态学
Global Change Biology Pub Date : 2024-10-19 DOI: 10.1111/gcb.17536
Longwei Dong, Jinzhi Ran, Jiali Luo, Lin Bai, Ying Sun, Muhammad Aqeel, Yahui Zhang, Xiaoting Wang, Qiajun Du, Junlan Xiong, Haiyang Gong, Qingqing Hou, Yan Deng, Rui Xia, Liang Wang, Fan Li, Chuancong Dong, Weigang Hu, Jie Peng, Ekaterina Filimonenko, Sulaiman Almwarai Alharbi, Jianxiao Zhu, Xiaogang Li, Chunjie Li, Jin-Sheng He, Karl J. Niklas, Yakov Kuzyakov, Jianming Deng
{"title":"Inorganic Carbon Pools and Their Drivers in Grassland and Desert Soils","authors":"Longwei Dong,&nbsp;Jinzhi Ran,&nbsp;Jiali Luo,&nbsp;Lin Bai,&nbsp;Ying Sun,&nbsp;Muhammad Aqeel,&nbsp;Yahui Zhang,&nbsp;Xiaoting Wang,&nbsp;Qiajun Du,&nbsp;Junlan Xiong,&nbsp;Haiyang Gong,&nbsp;Qingqing Hou,&nbsp;Yan Deng,&nbsp;Rui Xia,&nbsp;Liang Wang,&nbsp;Fan Li,&nbsp;Chuancong Dong,&nbsp;Weigang Hu,&nbsp;Jie Peng,&nbsp;Ekaterina Filimonenko,&nbsp;Sulaiman Almwarai Alharbi,&nbsp;Jianxiao Zhu,&nbsp;Xiaogang Li,&nbsp;Chunjie Li,&nbsp;Jin-Sheng He,&nbsp;Karl J. Niklas,&nbsp;Yakov Kuzyakov,&nbsp;Jianming Deng","doi":"10.1111/gcb.17536","DOIUrl":"10.1111/gcb.17536","url":null,"abstract":"<div>\u0000 \u0000 <p>Inorganic carbon is an important component of soil carbon stocks, exerting a profound influence on climate change and ecosystem functioning. Drylands account for approximately 80% of the global soil inorganic carbon (SIC) pool within the top 200 cm. Despite its paramount importance, the components of SIC and their contributions to CO<sub>2</sub> fluxes have been largely overlooked, resulting in notable gaps in understanding its distribution, composition, and responses to environmental factors across ecosystems, especially in deserts and temperate grasslands. Utilizing a dataset of 6011 samples from 173 sites across 224 million hectares, the data revealed that deserts and grasslands in northwestern China contain 20 ± 2.5 and 5 ± 1.3 petagrams of SIC in the top 100 cm, representing 5.5 and 0.76 times the corresponding soil organic carbon stock, respectively. Pedogenic carbonates (PIC), formed by the dissolution and re-precipitation of carbonates, dominated in grasslands, accounting for 60% of SIC with an area-weighted density of 3.4 ± 0.4 kg C m<sup>−2</sup> at 0–100 cm depth, while lithogenic carbonates (LIC), inherited from soil parent materials, prevailed in deserts, constituting 55% of SIC with an area-weighted density of 7.1 ± 1.0 kg C m<sup>−2</sup>. Soil parent materials and elevation determined the SIC stocks by regulating the formation and loss of LIC in deserts, whereas natural acidification, mainly induced by rhizosphere processes including cation uptake and H<sup>+</sup> release as well as precipitation, reduced SIC (mainly by PIC) in grasslands. Overall, the massive SIC pool underscores its irreplaceable role in maintaining the total carbon pool in drylands. This study sheds light on LIC and PIC and highlights the critical impact of natural acidification on SIC loss in grasslands.</p>\u0000 </div>","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Net Greenhouse Gas Balance in U.S. Croplands: How Can Soils Be Part of the Climate Solution?” 更正 "美国耕地的温室气体净平衡:土壤如何成为气候解决方案的一部分?
IF 10.8 1区 环境科学与生态学
Global Change Biology Pub Date : 2024-10-19 DOI: 10.1111/gcb.17538
{"title":"Correction to “Net Greenhouse Gas Balance in U.S. Croplands: How Can Soils Be Part of the Climate Solution?”","authors":"","doi":"10.1111/gcb.17538","DOIUrl":"10.1111/gcb.17538","url":null,"abstract":"<p>You, Y., Tian, H., Pan, S., Shi, H., Lu, C., Batchelor, W. D., Cheng, B., Hui, D., Kicklighter, D., Liang, X.-Z., Li, X., Melillo, J., Pan, N., Prior, S. A., &amp; Reilly, J. (2023). Net Greenhouse Gas Balance in U.S. Croplands: How Can Soils Be Part of the Climate Solution? Global Change Biology, 30, e17109. https://doi.org/10.1111/gcb.17109</p><p>In the article by You et al. (2023), we found an error in the unit of soil organic carbon (SOC) sequestration rate in Figure 2c. Specifically, the original unit was listed as g C/m<sup>2</sup>/year, but it should be g C/m<sup>2</sup>/experiment_duration. The data shown in Figure 2c represent the changes in SOC amount over the duration of the experimental period. In most of the papers we collected, the experimental duration for implementing specific agriculture practices (e.g., tillage) typically span multiple years (e.g., 5, 10 or 20 years). Consequently, these papers generally report changes in SOC amounts over the corresponding experimental period, rather than reporting an average annual SOC sequestration rate. Therefore, we compared our results (i.e., changes in SOC amount) with those papers over the same periods and experimental durations during model validation process.</p><p>To enhance comparability, we converted the original unit of observed SOC sequestration rates from g C/m<sup>2</sup>/experiment_duration to g C/m<sup>2</sup>/year and redrew Figure 2c. The main message of this article still upholds after correcting this mistake. The corrected version of Figure 2c is provided. Details of the experimental duration of these data points are also attached to this document (Table 1). Relevant changes and corrections related to Figure 2c made in the main text are also provided.</p><p>2.4 Model calibration, validation, and sensitivity analysis</p><p><b>Original text:</b> Overall, DLEM can well-simulate emissions of N<sub>2</sub>O and CH<sub>4</sub>, SOC sequestration rates, and SOC stocks compared with field observations from the metadata collection, in which RMSE (NRMSE) values were 0.16 g N m<sup>−2</sup> (9.6%), 1.5 g C m<sup>−2</sup> (4.4%), 156.9 g C m<sup>−2</sup> (19.3%), and 1929.1 g C m<sup>−2</sup> (17.6%), respectively, and the <i>R</i><sup>2</sup> values were 0.6, 0.91, 0.46, and 0.64, respectively (Figure 2).</p><p><b>Correct text:</b> Overall, DLEM can well-simulate emissions of N<sub>2</sub>O and CH<sub>4</sub>, SOC sequestration rates, and SOC stocks compared with field observations from the metadata collection, in which RMSE (NRMSE) values were 0.16 g N m<sup>−2</sup> (9.6%), 1.5 g C m<sup>−2</sup> (4.4%), 17.04 g C m<sup>−2</sup> (9.17%), and 1929.1 g C m<sup>−2</sup> (17.6%), respectively, and the <i>R</i><sup>2</sup> values were 0.6, 0.91, 0.44, and 0.64, respectively (Figure 2).</p><p>We apologize for this error.</p>","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/gcb.17538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of implementing stricter criteria for blood transfusion in patients with head and neck cancer undergoing free tissue transfer 对接受游离组织转移的头颈癌患者实施更严格输血标准的影响
IF 1.6 4区 医学
Laryngoscope Investigative Otolaryngology Pub Date : 2024-10-18 DOI: 10.1002/lio2.70021
Osama A. Hamdi MD, Deepa Danan MD, Amber Denner MD, Jeffrey R. Bellinger MD, Noah Thornton BS, David C. Shonka MD, Jonathan C. Garneau MD, Katherine Fedder MD, Mark J. Jameson MD, PhD, Eric M. Dowling MD
{"title":"Impact of implementing stricter criteria for blood transfusion in patients with head and neck cancer undergoing free tissue transfer","authors":"Osama A. Hamdi MD,&nbsp;Deepa Danan MD,&nbsp;Amber Denner MD,&nbsp;Jeffrey R. Bellinger MD,&nbsp;Noah Thornton BS,&nbsp;David C. Shonka MD,&nbsp;Jonathan C. Garneau MD,&nbsp;Katherine Fedder MD,&nbsp;Mark J. Jameson MD, PhD,&nbsp;Eric M. Dowling MD","doi":"10.1002/lio2.70021","DOIUrl":"https://doi.org/10.1002/lio2.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Recent literature studying the impact of blood transfusion on outcomes in patients with head and neck cancer (HNC) have shown that blood transfusions are associated with increased risk of death and higher wound infection rates. The purpose of this study was to implement a lower transfusion threshold while comparing outcomes of free flap patients following initiation of a new transfusion guideline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective study of all patients at a tertiary care academic center who underwent free tissue transfer after HNC resection between July 17, 2007 and June 7, 2021. Transfusion criteria were adjusted in 2014; the hematocrit threshold to transfuse was incrementally reduced from 30% in 2007 to 21% in 2017. The main outcomes of interest were overall survival (OS) and recurrence free survival (RFS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 346 patients met the criteria for inclusion in the study. Groups 1 (less strict protocol – 30%) and 2 (stricter protocol – 21%) consisted of 171 and 175 patients, respectively. Fewer units of packed red cells were transfused per patient in group 2 (0.26 vs. 2.87 in group 1, <i>p</i> &lt; .001). Group 1 was associated with worse OS (<i>p</i> = .01; hazard ratio [HR] = 1.7) and RFS (<i>p</i> &lt; .001; HR = 2.5). Comparing only patients with SCC between the two groups also demonstrated poorer OS (<i>p</i> = .01; HR = 1.8) and RFS (<i>p</i> = .006; HR = 2.1) in group 1.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In HNC patients undergoing free tissue transfer, stricter transfusion criteria with threshold hematocrit of 21% was associated with improved OS, RFS, and complication rates with no negative impact on free flap survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Masthead: (Small 42/2024) 桅顶:(小号 42/2024)
IF 13 2区 材料科学
Small Pub Date : 2024-10-18 DOI: 10.1002/smll.202470306
{"title":"Masthead: (Small 42/2024)","authors":"","doi":"10.1002/smll.202470306","DOIUrl":"10.1002/smll.202470306","url":null,"abstract":"","PeriodicalId":228,"journal":{"name":"Small","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202470306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Counterintuitive Trend of Intrusion Pressure with Temperature in the Hydrophobic Cu2(tebpz) MOF (Small 42/2024) 疏水性 Cu2(tebpz)MOF 中侵入压力随温度变化的反直觉趋势(小号 42/2024)
IF 13 2区 材料科学
Small Pub Date : 2024-10-18 DOI: 10.1002/smll.202470310
Sebastiano Merchiori, Andrea Le Donne, Ribhu Bhatia, Marta Alvelli, Jiang-Jing Yu, Xu-Dong Wu, Mian Li, Dan Li, Lukasz Scheller, Alexander R. Lowe, Monika Geppert-Rybczynska, Benjamin A. Trump, Andrey A. Yakovenko, Mirosław Chorążewski, Paweł Zajdel, Yaroslav Grosu, Simone Meloni
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