Wiley最新文献

{"title":"Toward ED Based Cardio Oncology Pathways From a Nationwide Arrhythmia Cohort","authors":"Yalcin Golcuk","doi":"10.1002/joa3.70167","DOIUrl":"https://doi.org/10.1002/joa3.70167","url":null,"abstract":"<p>The landmark study by Kobayashi and Kusano [<span>1</span>] provides invaluable insights into arrhythmia patterns among cancer patients using Japan's nationwide JROAD-DPC database. Despite the rising incidence of cardiovascular complications in oncology patients, few large-scale studies have examined arrhythmia profiles across cancer subtypes and treatment trajectories in real-world emergency settings. As emergency physicians (EPs) managing acute cardio-oncologic complications, we commend this study and wish to highlight three findings with critical implications for emergency care, along with opportunities to strengthen clinical translation.</p><p>The significantly higher rate of emergency admissions among cancer patients with arrhythmias (58.9% vs. 57.6% in non-cancer patients; <i>p</i> < 0.05) underscores a growing challenge for emergency departments (EDs). This finding aligns with global trends showing increasing cardiovascular emergencies related to malignancy due to aging populations and the widespread use of cardiotoxic therapies [<span>2</span>]. However, the underlying factors contributing to these admissions—whether related to arrhythmia severity, cancer progression, or gaps in outpatient care—remain insufficiently explored. Clarifying these drivers could enable the implementation of targeted interventions such as rapid-access cardio-oncology clinics or ED-based clinical triggers, including recurrent arrhythmia or recent chemotherapy exposure, for early cardiology consultation.</p><p>The predominance of atrial fibrillation or flutter (AF/AFL) among cancer-associated arrhythmias, comprising 70.6% of cases, has direct implications for acute management in the ED [<span>3</span>]. While the authors report lower anticoagulant use among cancer patients, EPs frequently face complex therapeutic dilemmas. Rhythm control may be constrained by QT-prolonging chemotherapies, and anticoagulation decisions must be cautiously balanced against risks of bleeding, especially in the context of thrombocytopenia or mucosal tumors. ED-specific algorithms would benefit from integrating oncology-informed variables such as current drug profiles, platelet counts, and malignancy characteristics to individualize AF management.</p><p>The observed frequencies of pneumonia (7.41%) and sepsis (2.26%) as clinical triggers for arrhythmia underscore the role of systemic inflammation in acute cardiac dysrhythmias. In the ED, febrile presentations in oncology patients often signal infection-related arrhythmogenic potential [<span>4</span>]. Embedding arrhythmia screening protocols, such as mandatory electrocardiograms for patients with febrile neutropenia, within sepsis bundles may support early detection of tachyarrhythmias and timely antimicrobial or hemodynamic intervention.</p><p>This study's use of nationwide claims data effectively captures broad epidemiologic trends; although coding limitations restrict the granularity of arrhythmia etiology and disease trajecto","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Obstructive Sleep Apnea on Cognition: An Analysis of Electroencephalography Microstates and Alpha Peak Frequency","authors":"Yan Wang,&nbsp;Ling Luo,&nbsp;Peilin Huang,&nbsp;Shaofan Jiang,&nbsp;Xiaodong Pan","doi":"10.1111/cns.70553","DOIUrl":"https://doi.org/10.1111/cns.70553","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Respiration-related sleep disorders such as obstructive sleep apnea (OSA) are risk factors for mild cognitive impairment and age-related neurocognitive deficits. Nearly 60% of patients with OSA suffer from a variety of impaired cognitive functions, including attention, working memory, and episodic memory, and are susceptible to mood disorders such as depression and anxiety. However, it remains largely unexplored regarding the features of the electroencephalography (EEG) microstates of these patients and the potential association between the EEG microstates and the cognitive impairments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>In this study, we performed polysomnography (PSG) on 70 patients who were recruited from the Department of Neurology and subsequently categorized into the OSA group (44 patients) and the non-OSA group (26 patients). We collected and analyzed their demographic information, blood and body fluid specimens, EEG alpha peak frequency, and EEG microstates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Compared with the non-OSA group, the OSA group reported more cases of comorbid anxiety symptoms (58.5% vs. 29%), and scored significantly lower in the word classification test. Of note, compared with the non-OSA counterparts, the OSA patients displayed markedly more microstate A, a significantly higher rate of B to A microstate conversion, and drastically lower Delta and Theta power at the F7-AV position.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings confirm that OSA may affect sleep quality and cognitive function by influencing EEG activity and microstates, which highlights a potential EEG network mechanism for OSA-induced cognitive impairment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thallium Isotopes Suggest the Global Deep Ocean Did Not Approach Modern Oxygenation During Cambrian Age 3 Metazoan Radiation","authors":"Jean N. R. Clemente,&nbsp;Haifeng Fan,&nbsp;Chadlin M. Ostrander,&nbsp;Hongjie Zhang,&nbsp;Hanjie Wen,&nbsp;Erik A. Sperling,&nbsp;Sune G. Nielsen","doi":"10.1111/gbi.70028","DOIUrl":"https://doi.org/10.1111/gbi.70028","url":null,"abstract":"<div>\u0000 \u0000 <p>The geologically rapid appearance of most extant animal groups in the Cambrian fossil record is often linked to enhanced ocean oxygenation. However, conflicting reconstructions of the Cambrian redox landscape make it difficult to determine the extent of ocean oxygenation during this significant biotic event, particularly regarding the redox state of the global deep ocean. In this study, we present authigenic thallium isotope compositions (ε²⁰⁵Tl_auth) for two shale sequences from South China (Qingjiang and Weng'an) that span the Cambrian Stage 2–3 boundary to the appearance of the Qingjiang biota, approximately 521–518 million years ago (Ma), a timeframe that chronicles a particularly rapid interval of metazoan diversification and radiation in the broader Cambrian explosion. If this event occurred amid modern-like extents of global ocean oxygenation, we would expect a significant increase in the global extent of seafloor Mn-oxide burial to drive lower ε²⁰⁵Tl_auth values near the modern open-ocean composition of −6‱. Instead, we observe broadly stable ε²⁰⁵Tl_auth values of around −3 to −4‱ in both studied sections. The lack of any significant Tl isotope shifts in our dataset argues against a short-term global ocean oxygenation event and suggests the global deep ocean was not characterized by modern extents of oxygenation 521–518 Ma. We reinterpret contemporaneous near-modern Mo and U isotope compositions to signal a relatively minor increase in marine oxygenation, likely limited to the continental shelves. However, ε²⁰⁵Tl_auth lower than the average isotopic composition of approximately −2‱ in Ediacaran shales suggests a shift to comparatively better-oxygenated conditions sometime between ~555 Ma and 521 Ma. If diversification at this time was linked to increased ocean oxygen levels, these changes were likely more dominant in the relatively shallow-water settings of continental shelves most densely populated by Cambrian animals and were incapable of dramatically altering seawater Tl isotope mass balance through seafloor Mn-oxide burial.</p>\u0000 </div>","PeriodicalId":173,"journal":{"name":"Geobiology","volume":"23 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Event-Triggered Based Adaptive Improved Terminal Sliding Mode Control of Multi-Manipulators System With Weak Communication Networks","authors":"Junxuan Luo,&nbsp;Fujie Wang,&nbsp;Shaoxiang Shi,&nbsp;Fang Guo,&nbsp;Yi Qin,&nbsp;Zhongye Xie,&nbsp;Ming Jiang","doi":"10.1049/cth2.70055","DOIUrl":"https://doi.org/10.1049/cth2.70055","url":null,"abstract":"<p>In this paper, an event-triggered adaptive improved terminal sliding mode controller is proposed for addressing the consensus tracking problem of multi-manipulators system under the weak communication networks. Firstly, an improved terminal sliding surface is designed to reduce the steady-state error of system. Then, by devising a variable-rate reaching law for sliding surface, the control chattering is greatly weakened. Furthermore, a trigger mechanism with time-varying threshold is incorporated into the designed controller to adjust the update frequency of the control law for conserving communication resources. This strikes a balance between tracking accuracy and resources conservation. Eventually, the tracking performance of the weak-connected system is greatly improved under the proposed algorithm. Based on Lyapunov stability theory, it is proven that the consensus tracking error of the system asymptotically converges to zero. Simulation results verify the effectiveness and performance improvement of the proposed scheme.</p>","PeriodicalId":50382,"journal":{"name":"IET Control Theory and Applications","volume":"19 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/cth2.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysing and Investigating the Effect of Heroin Use Disorder for the Changes of Distinguishing Features in Brain Signal Processing","authors":"Atefeh Tobieha,&nbsp;Neda Behzadfar,&nbsp;Mohammadreza Yousefi,&nbsp;Homayoun Mahdavi-Nasab,&nbsp;Ghazanfar Shahgholian","doi":"10.1049/smt2.70023","DOIUrl":"https://doi.org/10.1049/smt2.70023","url":null,"abstract":"<p>Heroin use disorder alters brain function, leading to significant changes in EEG signals. This study proposes a novel approach to identify distinguishing EEG features in heroin addicts and healthy individuals by integrating frequency and non-frequency domain features. The methodology consists of four main stages: (1) Preprocessing, where EEG signals undergo a 50 Hz notch filter and a Butterworth low-pass filter (0.4–45 Hz) to remove noise and artefacts; (2) Feature Extraction, in which both frequency-domain features (power spectral density in alpha, beta, theta, and delta bands) and non-frequency-domain features (approximate entropy, permutation entropy, wavelet entropy, and fractal dimensions of Katz and Petrosian) are computed; (3) Feature Selection, where the Davies–Bouldin index is employed to determine the most discriminative features, independent of the number of clusters; and (4) Analysis and Interpretation, which highlights that approximate entropy in the Cz channel and power spectral density in the upper alpha band in the O1 channel provide the highest discriminative power. Compared to previous studies that primarily rely on frequency-domain features, this approach captures both linear and nonlinear dynamics of EEG signals, leading to improved differentiation between addicted and healthy individuals. While the method demonstrates high accuracy, its sensitivity to EEG preprocessing and the need for larger datasets remain key considerations. The findings suggest that this framework can contribute to more effective addiction diagnosis and monitoring, with potential integration into machine learning-based EEG classification models.</p>","PeriodicalId":54999,"journal":{"name":"Iet Science Measurement & Technology","volume":"19 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/smt2.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds","authors":"Journal of Tissue Engineering and Regenerative Medicine","doi":"10.1155/term/9795348","DOIUrl":"https://doi.org/10.1155/term/9795348","url":null,"abstract":"<p>RETRACTION: T. S. Waris, S. T. Abbas Shah, A. Mehmood, et al., “Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds,” <i>Journal of Tissue Engineering and Regenerative Medicine</i> 2022 (2022): term.3295, https://doi.org/10.1002/term.3295.</p><p>The above article, published online on 4 March 2022 in Wiley Online Library (https://wileyonlinelibrary.com), has been retracted by agreement between the journal’s Chief Editor Catherine K. Kuo and John Wiley &amp; Sons Ltd.</p><p>The retraction has been agreed following an investigation of the concerns raised by <i>Mycosphaerella arachidis</i> on PubPeer [<span>1</span>], which identified unexpected similarities between multiple panels of Figure 6(a).</p><p>More specifically, the images depicting the wounds of animals in the Hep-W and Control-W groups after 20 days appear identical to the image of the T4-W group after 15 days. Further concerns have also been identified related to the similarity of two panels to images shown in Figure 7 from another publication by the author group, where they are attributed to a different experimental condition [<span>2</span>].</p><p>As a result of the investigation, the data and conclusions of this article are considered unreliable.</p><p>The authors disagree with this retraction.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2025 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/term/9795348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coastal Hypoxia in the Indian Ocean: Unraveling Drivers of Spatio-Temporal Variability","authors":"Fan Yang,&nbsp;Laure Resplandy,&nbsp;Yangyang Zhao,&nbsp;Sam Ditkovsky","doi":"10.1111/gcb.70378","DOIUrl":"https://doi.org/10.1111/gcb.70378","url":null,"abstract":"<p>Coastal hypoxia in the densely populated Indian Ocean regions has dramatic consequences for ecosystems and ecosystem services such as fisheries and coastal protection. However, inadequate understanding of the spatio-temporal variability of coastal hypoxia in the region, and its physical and biological drivers, poses a major challenge for anticipating these risks. Here we use <i>in-situ</i> observations and a high-resolution (1/12 degree) biophysical model of the Indian Ocean to map areas with heightened vulnerability to coastal hypoxia and identify the drivers of coastal oxygen dynamics. We find strong regional disparities in the mechanisms and temporal scales that govern coastal hypoxia: seasonal upwelling in the eastern Arabian Sea, interannual upwelling/downwelling linked to Indian Ocean Dipole events in the eastern Bay of Bengal, intraseasonal fluctuations introduced by coastal currents, Kelvin waves, and eddies along the western Bay of Bengal, and biologically driven oxygen variations at the mouth of major rivers in the northern Bay of Bengal (e.g., Ganges–Brahmaputra and Irrawaddy–Sittang Deltas). This basin-scale mapping identifies regions where intraseasonal hypoxia (e.g., western Bay of Bengal, river deltas) makes prediction of these events challenging and calls for intense monitoring, and regions where seasonal and interannual hypoxia (e.g., eastern Arabian Sea, eastern Bay of Bengal) facilitates the prevention of the adverse impacts on coastal ecosystems and their services.</p>","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":"31 8","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/gcb.70378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort.","authors":"Shanshan Yao, Megan M Marron, Samaneh Farsijani, Iva Miljkovic, George C Tseng, Ravi V Shah, Venkatesh L Murthy, Anne B Newman","doi":"10.1111/acel.70181","DOIUrl":"https://doi.org/10.1111/acel.70181","url":null,"abstract":"<p><p>Unintentional weight loss (UWL) is related to mortality and mobility limitation. Here, we aimed to develop a metabolite-based score for UWL and evaluate its prediction performance and explanation value for UWL-related health outcomes. Participants from the Health, Aging and Body Composition (Health ABC) study with available metabolomics and valid follow-ups were included (N = 2286). First, in the derivation group (N = 1200), 27 of the 77 metabolites associated with incident UWL (> 3% annual UWL vs. weight stable) were selected by LASSO-logistic regression. The UWL metabolite score was calculated as a weighted sum of these 27 standardized metabolites, with higher scores indicating greater UWL risk. We then examined the standardized UWL metabolite score against all-cause mortality and incident mobility limitation using Cox regression. Overall, older adults with a one-SD higher UWL metabolite score had higher risks for mortality (1.44 [1.36, 1.52]) and mobility limitation (1.23 [1.15, 1.32]). The score also improved mortality prediction beyond traditional risk factors. Similar results were observed in the hold-out test group (n = 1086). Furthermore, this score explained 28% of the UWL-mortality relationship and 22% of the UWL-mobility limitation relationship beyond lifestyle and medical history, respectively. The score also predicted higher mortality and mobility limitation among those with intentional weight loss and weight gain, demonstrating a good Out-Of-Distribution generalizability. This metabolomic characterization of UWL is predictive of key aging outcomes in the Health ABC participants and captures a substantial portion of the mortality and mobility limitation risks related to unintentional weight loss, further validating the importance of these metabolite signatures.</p>","PeriodicalId":119,"journal":{"name":"Aging Cell","volume":" ","pages":"e70181"},"PeriodicalIF":7.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-stretchable Transparent Hydrogels with Low Hydrophobic and Amphiphilic Monomers Using Asymmetric Crosslinker to Give Low Mechanical Hysteresis.","authors":"Hiroaki Yoshida, Takanori Maeno, Ryo Kawatani, Yumi Miyaji, Hiroharu Ajiro","doi":"10.1002/chem.202500778","DOIUrl":"https://doi.org/10.1002/chem.202500778","url":null,"abstract":"<p><p>Exploring a reasonable network design to develop highly stretchable hydrogels with over 1,000% extension is still a big challenge in the field of hydrogel chemistry and materials. Micellar copolymerization with hydrophobic monomers and surfactants/proteins is a well-studied approach to provide stretchable hydrogels with hydrophobic association domains as sacrificial bonds when subjected to large deformation, but some limitations, such as dose increase of such monomers and surfactant-free synthesis have not yet been well considered. In this study, we demonstrate a simple but powerful approach to produce transparent, ultra-stretchable hydrogels expressing more than 3,000% elongation by surfactant-free copolymerization of low hydrophobic monomer and amphiphilic monomer. We believe that this result offers wider availability of low hydrophobic groups in various water-containing polymer materials, including gels, micelles, etc.</p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e00778"},"PeriodicalIF":3.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLY-200, an oral pharmacologic duodenal exclusion drug, resulted in positive effects on glucose, lipids and bodyweight in patients with type 2 diabetes: Results of a randomized, double-blind placebo-controlled trial.","authors":"Christine L N Bryant, Kevin Colbert, Marcus Hompesch, SuZanne Chaves, Ashish Nimgaonkar, Mark S Fineman","doi":"10.1111/dom.16664","DOIUrl":"https://doi.org/10.1111/dom.16664","url":null,"abstract":"<p><strong>Aims: </strong>GLY-200 is an investigational oral polymeric drug designed to enhance the barrier function of gastrointestinal mucus as a non-invasive alternative to metabolic surgery. This study evaluated the safety, tolerability and pharmacodynamic effects of GLY-200 in patients with T2D.</p><p><strong>Materials and methods: </strong>This phase 2, placebo (PBO)-controlled, double-blind single-centre inpatient study (ClinicalTrials.gov, NCT05478525) enrolled patients (n = 51) aged 30-70 years with T2D (HbA1c ≥6.0% to <8.5%) on stable metformin ≥750 mg/day for ≥3 months. Patients received 14 days twice a day (BID) of 0.5, 1.0, or 2.0 g GLY-200 or PBO (1:1:1:1). The primary endpoint was safety and tolerability. Additional endpoints included changes in plasma glucose (secondary) and calories and lipid profiles (exploratory).</p><p><strong>Results: </strong>GLY-200 appeared safe and well tolerated. The most frequently related TEAEs in subjects treated with GLY-200 were constipation, nausea, diarrhoea and vomiting, all of which were mild. Improvements in fasting and postprandial glucose were observed. For 2.0 g Day 14 postprandial glucose post-standardized meal, mean absolute AUC_0-3HR difference from PBO was 178.33 mg/dL*hr (95% CI -327.16 to -29.50; p = 0.02); C_max difference was 50.88 mg/dL (-100.23 to -1.54; p = 0.04). Day 14 mean change from baseline fasting serum glucose in the 2.0 g group was -16.1 (SD 22.5) versus 12.1 (41.8) mg/dL in the PBO group. GLY-200 treatment also resulted in numerical reductions in food intake, modest decreases in body weight, and improvements in lipid profiles consistent with a duodenal exclusion mechanism.</p><p><strong>Conclusions: </strong>These results suggest duodenal exclusion is possible with an oral polymeric drug and support further development of GLY-200 for the treatment of T2D and obesity.</p>","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}