Wiley最新文献

{"title":"RETRACTION: MAEL Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Colorectal Cancer.","authors":"","doi":"10.1002/ijc.70739","DOIUrl":"10.1002/ijc.70739","url":null,"abstract":"<p><strong>Retraction: </strong>Q. Li, P. Wei, B. Huang, Y. Xu, X. Li, Y. Li, S. Cai, and D. Li, \"MAEL Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Colorectal Cancer,\" International Journal of Cancer 139, no. 11 (2016): 2502-2511, https://doi.org/10.1002/ijc.30388. The above article, published online on 30 July 2025 in Wiley Online Library (wileyonlinelibrary.com), and its erratum (https://doi.org/10.1002/ijc.33194), have been retracted by agreement between the journal Editor-in-Chief, Christoph Plass; the Union for International Cancer Control; and John Wiley & Sons Ltd. A third party reported on PubPeer [1] that images in Figure 3 were later published in another article by different authors [Jiang et al. 2018 (https://doi.org/10.1111/jcmm.13732)] and that Figure 1c(2) was also published in a separate article by different authors [Wu et al. 2018 (https://doi.org/10.7150/jca.26359)]. Further investigation by the publisher found that several lanes of the GAPDH bands in Figure 4a had been re-used and labeled as beta-actin in another article by some of the same authors [Li et al. 2018 (https://doi.org/10.7150/ijbs.24505)] and that there was evidence of duplication and splicing in Figures 2a and 3a. Additionally review by the editors found concerns about data handling that were not adequately addressed during peer review. Additionally, upon re-investigation, the authors' previous explanation for the erratum which replaced images in Figures 2d, 2g, and 2h was not considered satisfactory by either the editors or the publisher. The authors did not respond to an inquiry by the publisher. The retraction has been agreed to because the concerns over data handling, coupled with evidence that the authors have re-used data in a later article, fundamentally compromises the editors' confidence in the results in this article. The authors were informed of the retraction. REFERENCE: [1] Reese Richardson. Comments on \"MAEL expression links epithelial-mesenchymal transition and stem cell properties in colorectal cancer,\" PubPeer, July 2025. https://pubpeer.com/publications/E5633F92CB80ECA22A7893E2D6F840.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"220"},"PeriodicalIF":4.9,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Design and Initial Findings of a Natural History Study of Anal HPV and Associated Lesions Among Young Adult Women in Costa Rica\".","authors":"","doi":"10.1002/ijc.70757","DOIUrl":"10.1002/ijc.70757","url":null,"abstract":"","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"219"},"PeriodicalIF":4.9,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Comment on \"The Prognostic Potential of RNA in Stage II Colon Cancer: Insights From a Screened Multicenter Population-Based Cohort Study\".","authors":"Lasse S Kristensen, Ulrik Korsgaard, Henrik Hager","doi":"10.1002/ijc.70701","DOIUrl":"10.1002/ijc.70701","url":null,"abstract":"","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"3051-3052"},"PeriodicalIF":4.9,"publicationDate":"2026-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale Emergence of Pre-Harvest Sprouting in Cereals: From Seed Dormancy to Field-Level Resilience.","authors":"Deng-Ke Ma, Xiong Zhang, Wei Wang, A-Li Dai, Liu-Sheng Duan, Wei-Ming Tan","doi":"10.1111/pce.70852","DOIUrl":"10.1111/pce.70852","url":null,"abstract":"<p><p>Pre-harvest sprouting (PHS) represents a major threat to global food security under increasingly variable climatic conditions. Current understanding is largely derived from controlled laboratory studies, whereas field PHS is a multi-scale phenomenon resulting from interactions among genetic regulation, spike and grain traits, heterogeneous environmental conditions, and agronomic management. Our knowledge of PHS mechanisms under field conditions remains limited, and a systematic, integrated control framework is still lacking. In this review, we synthesise advances in the genetic architecture, physiological regulation, phenotypic determinants, and environmental factors of PHS in cereals, with emphasis on integrating multi-scale regulatory networks with environmental drivers. We particularly focus on laboratory-field discrepancies and how environmental heterogeneity influences grain quality deterioration and PHS outcomes under field conditions., and further evaluate current control strategies for PHS, including breeding, agronomic management, and chemical regulation, especially their limitations, environmental dependence, and associated trade-offs in practical application. Finally, we propose that future PHS control will require integrating field-relevant phenotypes, genotype × environment × management interactions, multi-scale predictive modelling, and decision-support systems to improve field-level resilience to PHS under increasingly variable climatic conditions.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"9770-9787"},"PeriodicalIF":6.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CsTBH-CsROP2 Module Regulates Waterlogging Tolerance via Auxin-Mediated Adventitious Root Formation in Cucumber.","authors":"Lei Sun, Fang Wang, Mingming Dong, Xi Zhao, Yaqi Zhang, Li Shan, Sen Li, Shuai Yin, Xinyue Ma, Tiantian Pei, Yingqi Shi, Zhigang Tang, Shaozhen He, Xingwang Liu, Huazhong Ren","doi":"10.1111/pce.70854","DOIUrl":"10.1111/pce.70854","url":null,"abstract":"<p><p>Cucumber (Cucumis sativus L.) requires frequent irrigation due to its shallow root system and high transpiration rate of the aboveground parts. However, it is also prone to waterlogging damage. Therefore, understanding its response to waterlogging is crucial for breeding waterlogging-tolerant varieties. Although Rho of Plants GTPases play well-established roles in regulating development and stress signalling, their functions in plant adaptation to waterlogging stress has yet to be fully elucidated. Here, we identified nine CsROP genes in the cucumber genome, which exhibit evolutionary diversification but retain conserved functional domains. Functional analysis revealed that CsROP2 acts as a negative regulator of adventitious root formation. It modulates auxin accumulation in hypocotyl vascular bundles, thereby suppressing adventitious root development and enhancing waterlogging sensitivity. The HD-Zip I transcription factor CsTBH directly binds the CsROP2 promoter and activates its expression. Our study uncovers a CsTBH-CsROP2 module that governs adventitious rooting and waterlogging tolerance by modulating auxin homeostasis. These findings provide new insights into the crosstalk between developmental programmes and stress signalling pathways and offer potential genetic targets for improving stress resilience in cucumber and other crops.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"9947-9969"},"PeriodicalIF":6.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The SlJAZ2/SlJAZ3 Dimer Acts as a Switch of the SlMYC2-SlPR2 Module to Regulate the Cf-19-Mediated Resistance of Tomatoes to Cladosporium fulvum.","authors":"Tong Pei, Xueli Jia, He Zhang, Dalong Li, Xiangyang Xu, Tingting Zhao","doi":"10.1111/pce.70873","DOIUrl":"10.1111/pce.70873","url":null,"abstract":"<p><p>Tomato leaf mold caused by Cladosporium fulvum (C. fulvum) is a devastating disease in tomato cultivation and production. The Cf gene confers resistance to C. fulvum. In our previous study, several JAZ family genes were found to be differentially expressed between resistant (Cf-19-mediated) and susceptible materials, especially SlJAZ3, whose expression was significantly upregulated during the Cf-19-mediated resistance response process. To explore the regulatory function of JAZ genes in this disease resistance system, this study focused on SlJAZ3 and found that both SlJAZ3 and its interacting protein SlJAZ2 can positively regulate the resistance response mediated by Cf-19. In addition, SlMYC2, as a positive regulator of the resistance response, can interact with SlJAZ2 (or SlJAZ3) and activate the expression of SlPR2. Notably, SlJAZ3 (or SlJAZ2) competitively binds to SlJAZ2 (or SlJAZ3), reducing its binding to SlMYC2, which helps to restore the transcriptional activation of the downstream defense gene SlPR2. Our findings reveal that the SlJAZ2/SlJAZ3 dimer regulates downstream signal transduction. This study has improved our understanding of Cf-mediated resistance and plant immune mechanisms, laying the foundation for the molecular improvement of tomato disease resistance and endows new significance to the formation of the JAZ-JAZ dimer.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"10133-10148"},"PeriodicalIF":6.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Changes in General and Central Adiposity and Subsequent Cardiometabolic Risk in Japanese Adults Undergoing Routine Health Screening.","authors":"Shinta Yamamoto, Hiroshi Okada, Tomohiro Shinozaki, Kenya Kasahara, Nozomi Kuramoto, Takahiro Ichikawa, Hanako Nakajima, Arata Sano, Yoshitaka Hashimoto, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi, Hiroaki Murata, Kazushiro Kurogi, Eri Tsuda, Naoki Yoshida, Masato Ito, Michiaki Fukui","doi":"10.1111/dom.71336","DOIUrl":"10.1111/dom.71336","url":null,"abstract":"<p><strong>Objective: </strong>Annual health screening provides repeated measurements of body mass index (BMI) and waist-based indices, but the implications of short-term changes in general and central adiposity for cardiometabolic risk remain unclear. We examined whether 1-year changes in BMI and waist-to-height ratio (WHtR) were associated with subsequent cardiometabolic outcomes and cardiovascular-kidney-metabolic (CKM) syndrome progression.</p><p><strong>Methods: </strong>We analysed longitudinal health examination data from 144 394 Japanese employees aged 40-74 years between 2008 and 2023. One-year changes in BMI and WHtR were calculated from two consecutive annual examinations, and outcomes were assessed during the following year. Outcomes included incident hypertension, dyslipidemia, hyperuricemia, diabetes, major adverse cardiovascular events, all-cause mortality, and CKM stage progression. Pooled logistic regression with natural cubic splines was used to assess nonlinear associations, with analyses stratified by baseline BMI or WHtR quartiles.</p><p><strong>Results: </strong>Increases in BMI and WHtR were consistently associated with higher risks of hypertension, dyslipidemia, hyperuricemia, and early CKM stage progression across baseline body size categories. For diabetes, increases in BMI and WHtR were associated with higher risk, whereas decreases were also associated with higher risk among leaner individuals. Associations with major adverse cardiovascular events were generally U-shaped. BMI loss was associated with higher mortality odds, although estimates were imprecise and potentially affected by reverse causation.</p><p><strong>Conclusions: </strong>One-year changes in BMI and WHtR were associated with subsequent cardiometabolic risk and CKM stage progression. Anthropometric changes, particularly weight loss, may serve as signals for further assessment rather than causal determinants of risk.</p>","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":"11343-11357"},"PeriodicalIF":6.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148965736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Adverse Event Reporting Patterns of Tirzepatide Versus Semaglutide: A Stratified Study of General and Healthcare Professional Cohorts in FAERS.","authors":"XingYu Liu, WenFang Wang","doi":"10.1111/dom.71373","DOIUrl":"10.1111/dom.71373","url":null,"abstract":"<p><strong>Background: </strong>Both the GLP-1 receptor agonist semaglutide and the novel dual GIP/GLP-1 receptor agonist tirzepatide have emerged as first-line therapeutic options for metabolic diseases. However, their real-world comparative safety profiles are difficult to interpret due to differential reporting composition in spontaneous reporting databases. This study compared their post-marketing adverse event (AE) reporting patterns and examined how reporter identity influences signal prominence.</p><p><strong>Methods: </strong>AE reports (May 2022-June 2026) from FAERS were analysed using ROR, PRR, information component (IC) and empirical Bayes geometric mean (EBGM); a signal required simultaneous four-method convergence; additionally, the Benjamini-Hochberg false discovery rate (FDR) procedure was used to ensure signal robustness against multiple testing. Head-to-head comparisons used the ratio of reporting odds ratios (RORR) with 95% CIs, run in parallel across general population and healthcare professional (HCP)-restricted subset, with sensitivity analyses by indication, seriousness, geography and calendar quarter.</p><p><strong>Results: </strong>A total of 151 654 tirzepatide and 64 987 semaglutide reports were analysed (HCP: 5.04% vs. 23.42%). Only semaglutide met four-method criteria for gastrointestinal (ROR 3.64) and metabolic (ROR 4.25) disorders in the general population (GI RORR 0.58, 95% CI 0.57-0.59). Pancreatitis signalled for both agents but attenuated to equivalence within T2DM (RORR 0.98, 95% CI 0.83-1.15). Diabetic ketoacidosis signalled exclusively for semaglutide in the HCP cohort (ROR 3.52); tirzepatide showed higher hypoglycaemia reporting (RORR 1.91, 95% CI 1.49-2.44). In the HCP cohort, tirzepatide GI ROR rose to 2.53 and semaglutide acquired eye disorder reporting signals (ROR 2.61). All sensitivity analyses (stratified by indication, seriousness, geography restriction and calendar quarter) confirmed directional stability of these comparative reporting patterns across subgroups.</p><p><strong>Conclusion: </strong>This FAERS-based analysis identifies distinct AE reporting patterns between tirzepatide and semaglutide that are sensitive to reporter type; all findings are hypothesis-generating and require confirmation with defined exposure denominators.</p>","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":"11721-11734"},"PeriodicalIF":6.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCRG1 Bridges Circadian Clock Regulation to Plant Developmental Transitions via Ubiquitin-Mediated Control.","authors":"Ran Chu, Jialin Wang, Zhen Wei","doi":"10.1111/pce.70918","DOIUrl":"10.1111/pce.70918","url":null,"abstract":"","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"10502-10504"},"PeriodicalIF":6.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pollen Carbonic Anhydrase Promotes Male Fertility Under Elevated Carbon Dioxide in Tomato.","authors":"Jianrong Lv, Haiming Ying, Chenxin Yue, Zhengran Zhao, Shurong Wu, Rui Deng, Wenshan Zai, Cunnian Fu, Huan Liu, Christine H Foyer, Kai Shi, Anran Wang","doi":"10.1111/pce.70919","DOIUrl":"10.1111/pce.70919","url":null,"abstract":"<p><p>Rising atmospheric CO₂ is a defining feature of climate change and profoundly influences plant growth and productivity. While the effects of elevated CO₂ on photosynthesis and vegetative biomass have been extensively studied, its direct impact on male reproductive development remains poorly understood. Here, we show that elevated CO₂ improves pollen vigour and performance in tomato (Solanum lycopersicum). Through genetic and molecular analyses, we identify β-type carbonic anhydrase 2 (βCA2) as a pollen-enriched CO₂ sensor required for this response. Loss of βCA2 abolishes the promoting effects of elevated CO₂ on fertility, whereas βCA2 overexpression mimics the high-CO₂ phenotype under ambient conditions. Further analyses revealed that βCA2 regulates downstream networks involved in vesicle trafficking and intracellular transport to promote pollen germination, alongside cellulose and pectin metabolism required for pollen intine remodelling. These findings suggest a potential link between βCA2-mediated CO₂ perception, intracellular transport and pollen intine remodelling. Our results uncover a dynamic, pollen-specific CO₂ response pathway that integrates intracellular transport with structural wall remodelling, providing new insights into how plants sustain male fertility under rising atmospheric CO₂.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"10520-10532"},"PeriodicalIF":6.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}