Wiley最新文献

{"title":"Cover Image, Volume 40, Issue 7","authors":"","doi":"10.1111/mice.13449","DOIUrl":"https://doi.org/10.1111/mice.13449","url":null,"abstract":"<p><b>The cover image</b> is based on the article <i>Multifidelity graph neural networks for efficient and accurate mesh-based partial differential equations surrogate modeling</i> by Negin Alemazkoor et al., https://doi.org/10.1111/mice.13312.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":156,"journal":{"name":"Computer-Aided Civil and Infrastructure Engineering","volume":"40 7","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/mice.13449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant chemotherapy in localized, resectable extremity and truncal soft tissue sarcoma and survival outcomes – A systematic review and meta-analysis of randomized controlled trials","authors":"Megan H. Goh BS,&nbsp;Marcos R. Gonzalez MD,&nbsp;Hillary M. Heiling PhD,&nbsp;Emanuele Mazzola PhD,&nbsp;Joseph J. Connolly BS,&nbsp;Edwin Choy MD PhD,&nbsp;Gregory M. Cote MD PhD,&nbsp;Dimitrios Spentzos MD MMSc,&nbsp;Santiago A. Lozano-Calderon MD PhD","doi":"10.1002/cncr.35792","DOIUrl":"https://doi.org/10.1002/cncr.35792","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The role of adjuvant chemotherapy in localized, resectable soft tissue sarcomas (STSs) remains controversial. Despite positive findings reported in previous meta-analyses, the majority of randomized controlled trials (RCTs) fail to show a meaningful benefit. We conducted an updated meta-analysis to reassess the role of adjuvant chemotherapy in treating localized, resectable STSs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature review was conducted to identify RCTs that compared local therapy (surgery with or without radiotherapy) to local therapy with adjuvant chemotherapy. Articles were independently reviewed, and risk of bias was assessed by two authors. The outcomes assessed were overall survival (OS) and disease-free survival (DFS). The meta-analysis was performed using a random effects model (to account for possible heterogeneity across studies) for survival endpoints with the inverse-variance method, in which each study is weighted with the inverse of the variance of its effect estimate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 19 RCTs comprising 2128 patients were included. Our study found that adjuvant chemotherapy improved OS (hazard ratio [HR], 0.80; <i>p</i> = .002) and DFS (HR, 0.78; <i>p</i> = .002). Doxorubicin-based monotherapy significantly improved OS (HR, 0.80; <i>p</i> = .01) and DFS (HR, 0.74; <i>p</i> = .0003), whereas doxorubicin-ifosfamide combined therapy did not significantly improve OS (HR, 0.78; <i>p</i> = .078) or DFS (HR, 0.94; <i>p</i> = .770). Doxorubicin-based ifosfamide combined therapy had moderate heterogeneity across studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study partially supports the benefit of adjuvant chemotherapy in the treatment of localized, resectable STSs. Nevertheless, because of the heterogeneity of STSs, the benefit and the risks of treatment with adjuvant chemotherapy need to be evaluated on an individual benefit–risk basis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":138,"journal":{"name":"Cancer","volume":"131 5","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radium levels in Brazil nuts: A review of the literature.","authors":"Christian Koeder, Markus Keller","doi":"10.1111/nbu.12717","DOIUrl":"10.1111/nbu.12717","url":null,"abstract":"<p><p>Brazil nuts are well known for their extraordinarily high selenium content. For this reason, they are frequently recommended as a kind of natural selenium 'supplement', particularly for certain population groups such as vegetarians and vegans in regions with low soil selenium levels. Typically, an intake of one or two Brazil nuts per day is recommended. Brazil nuts, however, also stand out from other nuts in terms of their high (albeit highly variable) radium content. The radium isotopes Ra-226 and Ra-228 emit alpha- and beta-radiation, with this type of radiation being particularly harmful when ingested. Consequently, it is important to consider radium levels in Brazil nuts before formulating recommendations for a long-term, daily intake of these nuts. To date, however, no comprehensive overview of radium levels in Brazil nuts has been published. Therefore, a literature review without time or language restrictions was conducted, including unpublished original data from Germany. The literature review (including the German data) indicated mean Ra-226 and Ra-228 levels of 49 (range: 17-205) mBq/g and 67 (range: 12-235) mBq/g, respectively. Assuming a consistent daily intake of one or two Brazil nuts, this would result in an effective dose of ~88-220 μSv/year. This level of exposure appears to be neither clearly harmful nor clearly harmless. As increased radioactivity exposure (at least at higher doses) is associated with increased cancer risk, randomised controlled trials assessing the effect of Brazil nuts on cancer risk biomarkers are needed.</p>","PeriodicalId":48536,"journal":{"name":"Nutrition Bulletin","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fats and cardiometabolic health-from public health to personalised nutrition: 'One for all' and 'all for one'.","authors":"Julie Anne Lovegrove","doi":"10.1111/nbu.12722","DOIUrl":"10.1111/nbu.12722","url":null,"abstract":"<p><p>This paper provides a summary of the 2023 British Nutrition Foundation Annual Lecture by Professor Julie Lovegrove. Professor Lovegrove is the head of the Hugh Sinclair Unit of Human Nutrition at the University of Reading. Professor Lovegrove, who was nominated for the BNF Prize for her outstanding contribution to nutritional sciences has published over 300 scientific papers and made a major contribution to establishing the relevance of dietary fat quality in the development and prevention of cardiometabolic disease.</p>","PeriodicalId":48536,"journal":{"name":"Nutrition Bulletin","volume":" ","pages":"132-141"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of macrophages in the pathogenesis of alcohol-associated liver disease.","authors":"Prakash Ramachandran, Frank Tacke","doi":"10.1097/HEP.0000000000000976","DOIUrl":"10.1097/HEP.0000000000000976","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"762-764"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S-pecial delivery: Implications of HBV surface antigen subviral particles carrying microRNA payloads.","authors":"Adam J Gehring","doi":"10.1097/HEP.0000000000001029","DOIUrl":"10.1097/HEP.0000000000001029","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"769-770"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning and digital pathology powers prediction of HCC development in steatotic liver disease.","authors":"Takuma Nakatsuka, Ryosuke Tateishi, Masaya Sato, Natsuka Hashizume, Ami Kamada, Hiroki Nakano, Yoshinori Kabeya, Sho Yonezawa, Rie Irie, Hanako Tsujikawa, Yoshio Sumida, Masashi Yoneda, Norio Akuta, Takumi Kawaguchi, Hirokazu Takahashi, Yuichiro Eguchi, Yuya Seko, Yoshito Itoh, Eisuke Murakami, Kazuaki Chayama, Makiko Taniai, Katsutoshi Tokushige, Takeshi Okanoue, Michiie Sakamoto, Mitsuhiro Fujishiro, Kazuhiko Koike","doi":"10.1097/HEP.0000000000000904","DOIUrl":"10.1097/HEP.0000000000000904","url":null,"abstract":"<p><strong>Background and aims: </strong>Identifying patients with steatotic liver disease who are at a high risk of developing HCC remains challenging. We present a deep learning (DL) model to predict HCC development using hematoxylin and eosin-stained whole-slide images of biopsy-proven steatotic liver disease.</p><p><strong>Approach and results: </strong>We included 639 patients who did not develop HCC for ≥7 years after biopsy (non-HCC class) and 46 patients who developed HCC <7 years after biopsy (HCC class). Paired cases of the HCC and non-HCC classes matched by biopsy date and institution were used for training, and the remaining nonpaired cases were used for validation. The DL model was trained using deep convolutional neural networks with 28,000 image tiles cropped from whole-slide images of the paired cases, with an accuracy of 81.0% and an AUC of 0.80 for predicting HCC development. Validation using the nonpaired cases also demonstrated a good accuracy of 82.3% and an AUC of 0.84. These results were comparable to the predictive ability of logistic regression model using fibrosis stage. Notably, the DL model also detected the cases of HCC development in patients with mild fibrosis. The saliency maps generated by the DL model highlighted various pathological features associated with HCC development, including nuclear atypia, hepatocytes with a high nuclear-cytoplasmic ratio, immune cell infiltration, fibrosis, and a lack of large fat droplets.</p><p><strong>Conclusions: </strong>The ability of the DL model to capture subtle pathological features beyond fibrosis suggests its potential for identifying early signs of hepatocarcinogenesis in patients with steatotic liver disease.</p>","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"976-989"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141069936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microchannel Liquid-Liquid Extraction of Crystal Violet (CV)","authors":"Jue Wang,&nbsp;Jia Yu,&nbsp;Hanhan Song,&nbsp;Yadong Zhang","doi":"10.1002/slct.202405498","DOIUrl":"https://doi.org/10.1002/slct.202405498","url":null,"abstract":"<p>Microchannel extraction technology was used to extract crystal violet (CV) from aqueous solutions with a T-type micromixer employed for phase mixing. The extractant di(2-ethylhexyl) phosphoric acid (D2EHPA) and the diluent (<i>n</i>-octanol) were used as the organic phase to extract CV from the aqueous phase. The experiment was conducted with a flow rate ratio of 1:1 for the aqueous and organic phases and investigated the effects of extractant concentration, initial aqueous phase <i>p</i>H, residence time, and mixing speed on the extraction efficiency of CV. The results showed that the extraction rate of CV can be changed by controlling the residence time and mixing speed. When the residence time was<span> </span>42.58 s, the extraction rate reached 99.39%. In batch extraction, the extraction rate of CV was 90.4% within 6 min, indicating that microchannel extraction had higher efficiency. As the phase mixing speed increased from 0.2 mL/min to 1.6 mL/min, the extraction efficiency decreased by 3.29%, although the overall volumetric mass transfer coefficient (<i>k</i>_La) slightly increased. In this study, the peak <i>k</i>_La value (0.728 s⁻¹) was 1 to 2 orders of magnitude higher than that of the batch extractor.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac energy metabolism is decreased in male volunteers with prediabetes and does not normalize during the day.","authors":"Vera H W de Wit-Verheggen, Jakob Wefers, Carlijn M E Remie, Patrick Schrauwen, Vera B Schrauwen-Hinderling, Tineke van de Weijer","doi":"10.14814/phy2.70242","DOIUrl":"10.14814/phy2.70242","url":null,"abstract":"<p><p>Type 2 diabetes mellitus is characterized by a low cardiac energy status (PCr/ATP ratio), but it is unknown whether this also applies to prediabetes. Since PCr/ATP is correlated with elevated free fatty acids (FFA), a potentially lower PCr/ATP might be secondary to elevated FFA. To investigate this, we determined PCr/ATP and FFA levels in volunteers with prediabetes at two time-points during the day. Eight male volunteers with prediabetes underwent a MRI/MRS scan to determine left ventricular ejection fraction (LVEF) and PCr/ATP ratio at 7 am and at 5 pm. For reference, these results were compared to eight non-insulin resistant overweight or obese volunteers. Myocardial energy status was lower in the volunteers with prediabetes (PCr/ATP 1.03 ± 0.08) compared to non-insulin resistant overweight or obese volunteers (PCr/ATP 1.22 ± 0.04, p < 0.05), but FFA were not significantly different between groups. LVEF was similar in the volunteers with prediabetes compared to healthy overweight and obese volunteers (p = 0.23). Volunteers with prediabetes have a lower myocardial energy status in the morning compared to healthy overweight and obese volunteers, while cardiac function remained normal. In addition, no differences between morning and evening measurements of cardiac energy status and function were found.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70242"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High school athletes' practical knowledge on where to find and order third-party tested nutritional supplements increases after education when compared to a control group.","authors":"Emily Dow, Kinta D Schott, Lindsay Morton, Hannah Lybbert, Kahyun Nam, Colin Shumate, Pamela Kulinna, Floris C Wardenaar","doi":"10.1111/nbu.12724","DOIUrl":"10.1111/nbu.12724","url":null,"abstract":"<p><p>To promote safe supplement use, athletes are advised to choose third-party tested (TPT) supplements to minimise doping risk. This study evaluated changes in knowledge on supplements in US high school athletes from a 2-week online supplement education programme. One group of sophomores (ED, n = 48) completed a Canvas course on safe supplement use, based on the Theory of Planned Behaviour, while the other group of freshmen (NOED, n = 38) did not. Participants completed questionnaires pre- and post-intervention to assess practical knowledge of finding and ordering TPT supplements, familiarity with World Anti-Doping Agency (WADA) banned substances and decision-making in supplement purchasing. Chi-Square and McNemar tests were applied with significance set at p ≤ 0.05. Pre-intervention no differences were found between groups (ages 14-17 years, 39.5% female) for any knowledge questions (p = 0.18). Post-intervention, ED participants were more likely to know where to find (58.3% vs. 39.5%, p = 0.041), and order (62.5% vs. 28.9%, p = 0.001) TPT supplements, and more athletes in ED (72.9%) than NOED (40.0%) reported deciding to purchase supplements themselves (p = 0.015). Parents were less influential in ED (75.0% vs. 92.1%, p = 0.019). Importantly, positive changes over time were larger for ED versus NOED in knowing where to find (28% vs. 13%, p = 0.04) and order (28% vs. 7%, p < 0.001) TPT supplements and WADA familiarity (19% vs. 5%, p = 0.01). Within-group changes showed ED improved on all practical knowledge questions (p = <0.001-0.008), whereas NOED only increased in knowing where to find TPT supplements (p = 0.003). These findings suggest an online educational programme may enhance practical knowledge of safe supplement use among high school athletes.</p>","PeriodicalId":48536,"journal":{"name":"Nutrition Bulletin","volume":" ","pages":"106-119"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}