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{"title":"Higher cost of gluten-free products compared to gluten-containing equivalents is mainly attributed to staple foods.","authors":"Eirini Bathrellou, Vasiliki Bountziouka, Despoina Lamprou, Evanthia Fragedaki, Eleftheria Papachristou, Frank Vriesekoop, Meropi D Kontogianni","doi":"10.1111/nbu.12716","DOIUrl":"10.1111/nbu.12716","url":null,"abstract":"<p><p>The high cost of gluten-free products (GFPs) is being discussed as a potential barrier to adherence to a gluten-free diet, rendering monitoring of their pricing an ongoing demand in a market subject to continuous fluctuations. The current study aimed to assess the current pricing status of GFPs in the Greek retail market, with a focus on differences between staple and non-staple foods. The retail price and packaging weight of all available GFPs and their gluten-containing (GCPs) counterparts of a GFP-shopping basket (formulated based on the results of a preceding online survey) were recorded by visiting one store of the five most popular reported supermarket chains. The food categories were grouped into staple (e.g. breads, pasta and flours) and non-staple (e.g. chips, sweets and sauces) foods. Adjusting for supermarket chain and product type, a quantile mixed regression model was applied to assess the extent to which median product price (per 100 g) differed between GFPs and GCPs. The unique products recorded were 1058 (of which 408 GFPs), with a total of 2165 retail price recordings. While the overall median price/100 g of GFPs was not found to be significantly different from that of GCPs, the median price of staple GFPs was estimated to be higher than staple GCPs (+€1.03 [95% CI: €0.93; €1.13] per 100 g), whilst that of non-staple GFPs was slightly lower (-€0.20 [95% CI: -€0.37; -€0.02] per 100 g). In conclusion, the persisting higher cost of staple GFPs suggests the need for ongoing financial support for people with coeliac disease.</p>","PeriodicalId":48536,"journal":{"name":"Nutrition Bulletin","volume":" ","pages":"44-51"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional intelligence in the food system: Combining food, health, data and AI expertise.","authors":"Danielle I McCarthy","doi":"10.1111/nbu.12729","DOIUrl":"10.1111/nbu.12729","url":null,"abstract":"<p><p>Transformative change is needed across the food system to improve health and environmental outcomes. As food, nutrition, environmental and health data are generated beyond human scale, there is an opportunity for technological tools to support multifactorial, integrated, scalable approaches to address the complexities of dietary behaviour change. Responsible technology could act as a mechanistic conduit between research, policy, industry and society, enabling timely, informed decision making and action by all stakeholders across the food system. Domain expertise in food, nutrition and health should always be integrated into both the development and continuous deployment of AI-powered nutritional intelligence (NI) to ensure it is responsible, accurate, safe, useable and effective. Dietary behaviours are complex and improving diet-related health outcomes requires socio-cultural-demographic considerations within the design and deployment of NI tools. This article describes existing examples of NI within the food system and future opportunities. Human-in-the-loop approaches with food, health and nutrition experts involved at all stages including data acquisition, processing, output validation and ongoing quality assurance are essential to ensure evidence-based practice. The same ethical considerations should apply in this domain as in any other (e.g. privacy, inclusivity, robustness, transparency and accountability) and responsible practice must encompass rigorous standards and alignment with regulatory frameworks. Critical today and in the future is accessibility to appropriate high-quality food compositional data sets, which include up-to-date information on commercially available products that reflect the constantly evolving food landscape to realise the potential of responsible AI to help address the existing food system challenges.</p>","PeriodicalId":48536,"journal":{"name":"Nutrition Bulletin","volume":" ","pages":"142-150"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NK-cell-elicited gasdermin-D-dependent hepatocyte pyroptosis induces neutrophil extracellular traps that facilitate HBV-related acute-on-chronic liver failure.","authors":"Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo","doi":"10.1097/HEP.0000000000000868","DOIUrl":"10.1097/HEP.0000000000000868","url":null,"abstract":"<p><strong>Background and aims: </strong>HBV infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF.</p><p><strong>Approach and results: </strong>We identified that pyroptosis represented the main cell death pattern in the liver of patients with HBV-related ACLF. Deficiency of MHC-I in HBV-reactivated hepatocytes activated cytotoxic NK cells, which in turn operated in a perforin/granzyme-dependent manner to trigger GSDMD/caspase-8-dependent pyroptosis of hepatocytes. Neutrophils selectively accumulated in the pyroptotic liver, and HMGB1 derived from the pyroptotic liver constituted an important factor triggering the generation of pathogenic extracellular traps in neutrophils (NETs). Clinically, elevated plasma levels of myeloperoxidase-DNA complexes were a promising prognostic biomarker for HBV-related ACLF. More importantly, targeting GSDMD pyroptosis-HMGB1 release in the liver abrogates NETs that intercept the development of HBV-related ACLF.</p><p><strong>Conclusions: </strong>Studying the mechanisms that selectively modulate GSDMD-dependent pyroptosis, as well as its immune landscapes, will provide a novel strategy for restoring the liver function of patients with HBV-related ACLF.</p>","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"917-931"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140304198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of glecaprevir/pibrentasvir for 8 weeks in the treatment of patients with acute hepatitis C: A single-arm retrospective study.","authors":"Stanislas Pol, Alexander J Thompson, Michelle Collins, Elisa Venier, Laurent Cotte, Montserrat Laguno Centeno, Jorge Mera, Thomas Reiberger, Margaret Burroughs, Dimitri G Semizarov, Alexandru M Iacob, Anne Welhaven, Linda M Fredrick, Joseph S Doyle","doi":"10.1097/HEP.0000000000000923","DOIUrl":"10.1097/HEP.0000000000000923","url":null,"abstract":"<p><strong>Background and aims: </strong>No direct-acting antiviral is currently approved for acute HCV infection, delaying treatment. We investigated the effectiveness and safety of 8-week glecaprevir/pibrentasvir (G/P) in patients with acute HCV infection.</p><p><strong>Approach and results: </strong>This noninterventional, single-arm, retrospective chart review was designed to enroll adults/adolescents with acute HCV infection. Analyses were conducted on a full analysis set (FAS; all enrolled) and modified FAS (FAS excluding nonvirologic failures). The primary end point (modified FAS) was sustained virologic response at posttreatment week 12 (SVR12) with superiority to 92.6% threshold determined by historic chronic HCV G/P SVR12 rates. Secondary end points (FAS) included SVR12, on-treatment virologic failure, posttreatment relapse, and reinfection. Adverse events and safety laboratory values were assessed.Overall, 202 adults were enrolled; in the modified FAS, 150/151 (99.3%; 95% CI: 96.3-99.9) achieved SVR12, demonstrating superiority to efficacy threshold. In the FAS, the SVR12 rate was 74.3% and the on-treatment virologic failure rate was 0%. Relapse and reinfection rates after the final treatment visit (FAS) were 0.5% and 3%, respectively; 39 patients had missing SVR12 data. No on-treatment alanine aminotransferase elevations > 3 × upper limit of normal with total bilirubin > 2 × upper limit of normal were reported. All 53 patients with alanine aminotransferase Grade ≥ 2 at baseline improved to Grade 0/1 on treatment. No adverse eventss of hepatic decompensation/failure or leading to G/P discontinuation occurred. Two patients had serious adverse events unrelated to G/P.</p><p><strong>Conclusions: </strong>Eight-week G/P therapy was effective and well-tolerated in patients with acute HCV infection. Data support further investigation of G/P in acute HCV to shorten care cascades, reduce transmission, and support HCV elimination.</p>","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"1006-1018"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141069940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-mediated circulating tumor cell evasion from natural killer cell killing through immune checkpoint CD155-TIGIT.","authors":"Yunfan Sun, Tong Li, Lin Ding, Jiyan Wang, Chen Chen, Te Liu, Yu Liu, Qian Li, Chuyu Wang, Ran Huo, Hao Wang, Tongtong Tian, Chunyan Zhang, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wenjing Yang, Beili Wang, Wei Guo","doi":"10.1097/HEP.0000000000000934","DOIUrl":"10.1097/HEP.0000000000000934","url":null,"abstract":"<p><strong>Background and aims: </strong>Circulating tumor cells (CTCs) are precursors of cancer metastasis. However, how CTCs evade immunosurveillance during hematogenous dissemination remains unclear.</p><p><strong>Approach and results: </strong>We identified CTC-platelet adhesions by single-cell RNA sequencing and multiplex immunofluorescence of blood samples from multiple cancer types. Clinically, CTC-platelet aggregates were associated with significantly shorter progression-free survival and overall survival in patients with HCC. In vitro, ex vivo, and in vivo assays demonstrated direct platelet adhesions gifted cancer cells with an evasive ability from NK cell killing by upregulating inhibitory checkpoint CD155 (PVR cell adhesion molecule), therefore facilitating distant metastasis. Mechanistically, CD155 was transcriptionally regulated by the FAK/JNK/c-Jun cascade in a platelet contact-dependent manner. Further competition assays and cytotoxicity experiments revealed that CD155 on CTCs inhibited NK-cell cytotoxicity only by engaging with immune receptor TIGIT, but not CD96 and DNAM1, another 2 receptors for CD155. Interrupting the CD155-TIGIT interactions with a TIGIT antibody restored NK-cell immunosurveillance on CTCs and markedly attenuated tumor metastasis.</p><p><strong>Conclusions: </strong>Our results demonstrated CTC evasion from NK-cell-mediated innate immunosurveillance mainly through immune checkpoint CD155-TIGIT, potentially offering an immunotherapeutic strategy for eradicating CTCs.</p>","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"791-807"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC.","authors":"Yujia Xia, Yu Wang, Qi Xiong, Jiayi He, Han Wang, Mozaffarul Islam, Xinyu Zhou, Alex Kim, Hongji Zhang, Hai Huang, Allan Tsung","doi":"10.1097/HEP.0000000000000762","DOIUrl":"10.1097/HEP.0000000000000762","url":null,"abstract":"<p><strong>Background and aims: </strong>Metabolic dysfunction-associated steatohepatitis (MASH) fibrosis is a reversible stage of liver disease accompanied by inflammatory cell infiltration. Neutrophils extrude a meshwork of chromatin fibers to establish neutrophil extracellular traps (NETs), which play important roles in inflammatory response regulation. Our previous work demonstrated that NETs promote HCC in MASH. However, it is still unknown if NETs play a role in the molecular mechanisms of liver fibrosis.</p><p><strong>Approach and results: </strong>Following 12 weeks of Western diet/carbon tetrachloride, MASH fibrosis was identified in C57BL/6 mice with increased NET formation. However, NET depletion using DNase I treatment or mice knocked out for peptidyl arginine deaminase type IV significantly attenuated the development of MASH fibrosis. NETs were demonstrated to induce HSCs activation, proliferation, and migration through augmented mitochondrial and aerobic glycolysis to provide additional bioenergetic and biosynthetic supplies. Metabolomic analysis revealed markedly an altered metabolic profile upon NET stimulation of HSCs that were dependent on arachidonic acid metabolism. Mechanistically, NET stimulation of toll-like receptor 3 induced cyclooxygenase-2 activation and prostaglandin E2 production with subsequent HSC activation and liver fibrosis. Inhibiting cyclooxygenase-2 with celecoxib reduced fibrosis in our MASH model.</p><p><strong>Conclusions: </strong>Our findings implicate NETs playing a critical role in the development of MASH hepatic fibrosis by inducing metabolic reprogramming of HSCs through the toll-like receptor 3/cyclooxygenase-2/cyclooxygenase-2 pathway. Therefore, NET inhibition may represent an attractive treatment target for MASH liver fibrosis.</p>","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"947-961"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139544890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kupffer cell diversity maintains liver function in alcohol-associated liver disease.","authors":"Kyo Sasaki, Sheetalnath Rooge, Sumedha Gunewardena, Janice Averilla Hintz, Priyanka Ghosh, Isabel Aranzazu Pulido Ruiz, Kyle Yuquimpo, Michael Schonfeld, Heer Mehta, Heather L Stevenson, Omar A Saldarriaga, Esteban Arroyave, Irina Tikhanovich, Ann L Wozniak, Steven A Weinman","doi":"10.1097/HEP.0000000000000918","DOIUrl":"10.1097/HEP.0000000000000918","url":null,"abstract":"<p><strong>Background and aims: </strong>Liver macrophages are heterogeneous and play an important role in alcohol-associated liver disease (ALD) but there is limited understanding of the functions of specific macrophage subsets in the disease. We used a Western diet alcohol (WDA) mouse model of ALD to examine the hepatic myeloid cell compartment by single cell RNAseq and targeted KC ablation to understand the diversity and function of liver macrophages in ALD.</p><p><strong>Approach and results: </strong>In the WDA liver, KCs and infiltrating monocytes/macrophages each represented about 50% of the myeloid pool. Five major KC clusters all expressed genes associated with receptor-mediated endocytosis and lipid metabolism, but most were predicted to be noninflammatory and antifibrotic with 1 minor KC cluster having a proinflammatory and extracellular matrix degradation gene signature. Infiltrating monocyte/macrophage clusters, in contrast, were predicted to be proinflammatory and profibrotic. In vivo, diphtheria toxin-based selective KC ablation during alcohol exposure resulted in a liver failure phenotype with increases in PT/INR and bilirubin, loss of differentiated hepatocyte gene expression, and an increase in expression of hepatocyte progenitor markers such as EpCAM, CK7, and Igf2bp3. Gene set enrichment analysis of whole-liver RNAseq from the KC-ablated WDA mice showed a similar pattern as seen in human alcoholic hepatitis.</p><p><strong>Conclusions: </strong>In this ALD model, KCs are anti-inflammatory and are critical for the maintenance of hepatocyte differentiation. Infiltrating monocytes/macrophages are largely proinflammatory and contribute more to liver fibrosis. Future targeting of specific macrophage subsets may provide new approaches to the treatment of liver failure and fibrosis in ALD.</p>","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"870-887"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5-Sulfosalicylic Acid Dihydrate-Catalyzed Multicomponent Synthesis of 3-(Arylamino)-Furan-2(5H)-ones","authors":"Dhananjay D. Gadge,&nbsp;Pramod S. Kulkarni","doi":"10.1002/slct.202405870","DOIUrl":"https://doi.org/10.1002/slct.202405870","url":null,"abstract":"<p>This study explores an efficient one-pot, three-component synthesis of highly functionalized furan-2(5<i>H</i>)-one molecules using 5-sulfosalicylic acid dihydrate (5-SSA) as an organocatalyst. The reaction involves dimethyl acetylenedicarboxylate, amines, and arylaldehyde in ethanol under mild conditions achieving high yields (80%–96%) with short reaction times. 5-SSA in 10 mol% loading proved to be a superior catalyst compared to other tested organocatalysts offering a green and practical approach to synthesizing furan-2(5<i>H</i>)-one molecules. The catalyst activates arylaldehyde through protonation enhancing the nucleophilic attack of enamine. Additionally, it assists in the cyclization step by stabilizing intermediates leading to efficient product formation. The scope of the reaction was further investigated with various substituted amines and aldehydes, showing good functional group tolerance. We characterized the synthesized compounds using FTIR, NMR, and HRMS techniques. This methodology offers an environmentally friendly and efficient route for synthesizing furan-2(5<i>H</i>)-one heterocyclic compounds.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing methods to measure the dispersion of breathing parameters during exercise testing: A simulation study based on real-life parameters from patients with dysfunctional breathing.","authors":"Léon Genecand, Cyril Jaksic, Roberto Desponds, Gaëtan Simian, Ivan Guerreiro, Sara Thorens, Marco Altarelli, Isabelle Frésard, Chloé Cantero, Aurélien Bringard, Antoine Beurnier, Pierantonio Laveneziana, David Montani, Anne Bergeron, Frédéric Lador, Pierre-Olivier Bridevaux","doi":"10.14814/phy2.70233","DOIUrl":"https://doi.org/10.14814/phy2.70233","url":null,"abstract":"<p><p>The dispersion of the tidal volume and of the breathing frequency have been used to diagnose dysfunctional breathing during cardio-pulmonary exercise testing. No validated methods to objectively describe this dispersion exist. We aimed to validate such a method. We used simulations based on real-life parameters. Moving standard deviation (MSD) and residuals from locally estimated scatterplot smoothing (LOESS) were evaluated. The precision and the bias of each tested method at rest and during exercise simulations, with and without sighs, were measured. For LOESS, a 2nd degree polynomial was used, and different spans were tested (LOESS₁, LOESS_0.75, and LOESS_0.5). For MSD, different number of points used for the calculation were tested (MSD₇, MSD₁₁, MSD₁₅, and MSD19). The LOESS method was globally more precise, had less bias, and was less influenced by the trend as compared to MSD in almost all simulations except for extremely low dispersion combined with extreme trends. LOESS_0.75 had intermediate bias and precision between LOESS_0.5 and LOESS₁ in all simulations. LOESS_0.75 is a method that combines high precision, low bias, and low influenceability of trends. It could be considered as the method of choice to evaluate the dispersion of breathing parameters during cardiopulmonary exercise testing.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70233"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AASLD Practice Guideline on noninvasive liver disease assessment of portal hypertension.","authors":"Richard K Sterling, Sumeet K Asrani, Deborah Levine, Andres Duarte-Rojo, Keyur Patel, Maria Isabel Fiel, Daniel H Leung, Bachir Taouli, Mouaz Alsawas, M Hassan Murad, Jonathan A Dranoff, Tamar H Taddei, Don C Rockey","doi":"10.1097/HEP.0000000000000844","DOIUrl":"10.1097/HEP.0000000000000844","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":" ","pages":"1060-1085"},"PeriodicalIF":12.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}