Wiley最新文献

{"title":"Understanding Ferruginous Versus Euxinic Conditions by Simulating Microbial Conditions in Meromictic Lakes","authors":"Vanessa M. Hawkins,&nbsp;Cody S. Sheik,&nbsp;Sergei Katsev","doi":"10.1111/gbi.70037","DOIUrl":"https://doi.org/10.1111/gbi.70037","url":null,"abstract":"<p>Ferruginous (iron-rich) conditions have been prominent in oceans throughout the Earth's geologic history but now are reliably found only in a handful of permanently stratified lakes. Microbially mediated iron reduction in such anoxic environments competes with sulfate reduction, which promotes euxinic (sulfide-rich) conditions. Besides the shared demand for organic compounds, the competition is fostered by the produced hydrogen sulfide, which may reduce iron oxides abiotically or co-precipitate with dissolved iron as iron sulfides. Understanding why some environments develop ferruginous rather than euxinic conditions (or vice versa), as well as the attendant effects on methanogenic fermentation, is key to understanding both modern and ancient anoxic ecosystems. Here, we reproduce biogeochemical distributions in multiple anoxic, low-sulfate, meromictic lakes around the world using a biomass-explicit reaction-transport model with a fixed set of metabolism-specific microbial parameters. The results suggest that sulfate reduction and methanogenesis are ubiquitous even in iron-rich systems, and are reflected in microbial surveys. Ferruginous conditions typically develop for surface sulfate concentrations below ≃100 μM. Interestingly, there seems to be a dearth of stably stratified water bodies where sulfate concentrations can persist in the medium-sulfate range of several hundred μM. Rather, when sulfur burial into the sediments becomes iron limited, sulfate tends to accumulate in the water column to much higher (mM) concentrations. A similar mechanism could be suggested to have operated in the variably sulfidic and ferruginous water columns of early oceans. Model simulations also reveal the previously underappreciated role of physical transport in shaping biogeochemical distributions, as minor variations in mixing rates can lead to large variations in microbial abundances. Model applicability across multiple lakes points to an encouraging possibility that geochemical patterns in complex biogeochemical systems may be described from a small number of thermodynamic and kinetic principles using a minimum of fitting parameters.</p>","PeriodicalId":173,"journal":{"name":"Geobiology","volume":"23 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/gbi.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatinine: A Muscle Metabolite as a Multifunctional Electrolyte Additive for Aqueous Zinc-Ion Batteries (Small Methods 10/2025)","authors":"Yusheng Lu,&nbsp;Yaming Jiang,&nbsp;Jinlan Yi,&nbsp;Yang Wei,&nbsp;Fei Wang,&nbsp;Shenghong Zhong,&nbsp;Yan Yu","doi":"10.1002/smtd.70057","DOIUrl":"https://doi.org/10.1002/smtd.70057","url":null,"abstract":"<p><b>Aqueous Zinc-Ion Batteries</b></p><p>In article number 2500188, Zhong, and co-workers demonstrated highly reversible AZIBs by introducing creatinine—a muscle metabolite—into the ZnSO₄ electrolyte. This eco-friendly, biocompatible organic molecule modifies the solvation structure of Zn²⁺ via its carbonyl group, adsorbs on the zinc anode to establish a water-deficient electric double layer, and promotes preferential Zn²⁺ deposition on the (002) crystallographic plane.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 10","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate Metabolism in Intervertebral Disc Degeneration: Unveiling Novel Mechanisms Through Bioinformatics","authors":"Haiyan Sun,&nbsp;Mingwei He,&nbsp;Jinlei Pang,&nbsp;Xiangfei Guo,&nbsp;Yansong Huo,&nbsp;Jun Ma","doi":"10.1002/jsp2.70126","DOIUrl":"https://doi.org/10.1002/jsp2.70126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intervertebral disc degeneration (IDD) is a widespread issue associated with chronic lumbar pain and disability. This study aimed to identify lactate metabolism-related genes in IDD and elucidate their mechanistic roles in disease progression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>IDD datasets were analyzed using R packages GEOquery, sva, and limma for data retrieval, batch correction, and normalization. Differential gene expression analysis identified significant genes between IDD and control groups, from which lactate metabolism-related differentially expressed genes (LMRDEGs) were derived. Relationships among the LMRDEGs were assessed using Spearman's correlation analysis, and functional enrichment was conducted using ClusterProfiler. Gene set enrichment analysis identified biological processes associated with IDD. Diagnostic models were assessed using receiver operating characteristic (ROC) curve. Immune cell infiltration and correlations with core genes were analyzed via the CIBERSORT algorithm. Regulatory networks were constructed, and reverse transcription quantitative polymerase chain reaction (RT-qPCR) was employed to validate the expression of hub LMRDEGs in IDD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1325 differentially expressed genes were identified, yielding seven LMRDEGs: <i>TGFβ2</i>, <i>GSR</i>, <i>MB</i>, <i>MMP2</i>, <i>SLC16A7</i>, <i>PER2</i>, and <i>STAT3</i>, which are enriched in blood circulation regulation and hypoxic response, as well as pathways like AGE–RAGE signaling in diabetic complications. ROC analysis indicated potential hub genes (<i>MMP2, MB, TGFβ2</i>, and <i>PER2</i>), while immune infiltration analysis uncovered significant variations in immune cell distribution. RT-qPCR confirmed <i>MMP2</i>, <i>MB</i>, and <i>SLC16A7</i> as molecular indicators reflecting lactate metabolism abnormalities in IDD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study clarifies how lactate metabolism contributes to IDD through molecular mechanisms and its interplay with immunological features, providing a theoretical basis for understanding the early pathogenesis of IDD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14876,"journal":{"name":"JOR Spine","volume":"8 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jsp2.70126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Disassembling Macroporous Metal–Organic Framework-Based Micromotors with Magnetically Controlled Motion for Sequential Drug Release (Small Methods 10/2025)","authors":"Javier Bujalance Fernández,&nbsp;Víctor de la Asunción-Nadal,&nbsp;Beatriz Jurado Sánchez,&nbsp;Alberto Escarpa","doi":"10.1002/smtd.70058","DOIUrl":"https://doi.org/10.1002/smtd.70058","url":null,"abstract":"<p><b>Sequential Drug Release</b></p><p>MOF-based magnetic micromotors self-degrade to release two drugs in a controlled and sequential manner at the acidic cancer cells media. The magnetic propulsion of the micromotors facilitates targeted delivery to pre-designated locations, enabling interaction with cancer cells in the culture medium. This approach allows for controlled binding, transport, and membrane rupture toward future in-vivo treatment of tumors. More in article number 2500724, Sánchez, Escarpa, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 10","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal-Free Multicomponent Upcycling of Polybutadiene to Sulfonamide-Functionalized Materials","authors":"Janna Jeschke,&nbsp;Jan Hobich,&nbsp;Hatice Mutlu","doi":"10.1002/marc.70082","DOIUrl":"https://doi.org/10.1002/marc.70082","url":null,"abstract":"<p><b>Back Cover</b>: From Commodity to Complexity: A metal-free, one-pot upcycling strategy transforms polybutadiene into sulfonamide-decorated polymers under mild conditions. The reaction combines backbone editing and side-chain diversification, yielding luminescent, functional materials with potential in sensing, biointerfaces, and post-modification chemistry. More details can be found in the Research Article by Hatice Mutlu an co-workers (DOI: 10.1002/marc.202500311).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"46 20","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/marc.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate-Driven Increase in Transmission of a Wildlife Malaria Parasite Over the Last Quarter Century","authors":"Angela Nicole Theodosopoulos,&nbsp;Fredrik Andreasson,&nbsp;Jane Jönsson,&nbsp;Johan Nilsson,&nbsp;Andreas Nord,&nbsp;Lars Råberg,&nbsp;Martin Stjernman,&nbsp;Ana Sofía Torres Lara,&nbsp;Jan-Åke Nilsson,&nbsp;Olof Hellgren","doi":"10.1111/gcb.70550","DOIUrl":"https://doi.org/10.1111/gcb.70550","url":null,"abstract":"<p>Climate warming is expected to influence the prevalence of vector-transmitted parasites. Understanding the extent to which this is ongoing, or has already occurred, requires empirical data from populations monitored over long periods of time, but these studies are sparse. Further, vector-disease research involving human health is often influenced by disease control efforts that supersede natural trends. By screening for malaria parasite infections in a wild population of blue tits (<i>Cyanistes caeruleus</i>) in Northern Europe, over a 26-year period, we tested whether prevalence and transmission changes were climate-driven. We found that all three malaria parasite genera occurring in blue tits (<i>Haemoproteus</i>, <i>Plasmodium</i>, and <i>Leucocytozoon</i>) have increased significantly in their prevalence and transmission over time. The most common parasite in the study, <i>Haemoproteus majoris</i>, increased in prevalence from 47% (1996) to 92% (2021), and this was a direct consequence of warmer temperatures elevating transmission. Climate window analyses revealed that elevated temperatures between May 9th and June 24th, a time period that overlaps with the host nestling period, were strongly positively correlated with <i>H. majoris</i> transmission in one-year-old birds. A warming climate during this narrow timeframe has had a demonstrable impact on parasite transmission, and this has favored an increase in the prevalence of parasites in wild birds in a temperate region of Europe. While more challenging to measure, similar implications of climate warming on human vector-disease systems might be occurring. It is therefore critical that we understand what specific aspects of malaria parasite development and transmission are most influenced by climate warming, for the benefit of human and wildlife health.</p>","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":"31 10","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/gcb.70550","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring Colour Centres of Host-Dopant Light Emitters by X-Ray Radiations (Small Methods 10/2025)","authors":"Weidian Li,&nbsp;Siyuan He,&nbsp;Wenfa Chen,&nbsp;Pin Lyu,&nbsp;Ying Liu,&nbsp;Jincheng Bao,&nbsp;Caixia Kan,&nbsp;Mingming Jiang,&nbsp;Shuiyan Cao,&nbsp;Yanpeng Liu","doi":"10.1002/smtd.70067","DOIUrl":"https://doi.org/10.1002/smtd.70067","url":null,"abstract":"<p><b>Light Emitters</b></p><p>In article number 2402180, Cao, Liu, and co-workers tailored the electroluminescence (EL) intensity and color coordinate of Ga-doped ZnO microwires by X-ray irradiation. DFT calculations suggest that the EL enhancement and tailored color presumably stem from the substitution of host Zn atoms by interstitial Ga dopant stimulated by high-energy X-ray, which indicates X-ray irradiation a potential post-treatment strategy for host-dopant light emitters toward practical applications.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 10","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoplasmonic Sensing of Heterogeneous Extracellular Vesicles: From Bulk to Single Vesicles (Small Methods 10/2025)","authors":"Yan Zhang,&nbsp;Chao Wang,&nbsp;Huilin Shao","doi":"10.1002/smtd.70052","DOIUrl":"https://doi.org/10.1002/smtd.70052","url":null,"abstract":"<p><b>Front Cover</b></p><p>In article number 2500097, Shao and co-workers present an articulate framework for nanoplasmonic sensing of extracellular vesicles (EVs), reviewing recent advances in size-matched technologies for bulk EV analysis and single-vesicle profiling. The article further provides an outlook on emerging opportunities, at the interface of biomarker discovery and technology innovation, to develop empowering nanoplasmonic EV platforms for personalized medicine.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 10","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin Modulates Copper Homeostasis Through NO Dependent Manner in Rice (Oryza sativa L.)","authors":"Jing Huang,&nbsp;Hao Yu Wang,&nbsp;Jia Qi Li,&nbsp;Ren Fang Shen,&nbsp;Lu Zheng,&nbsp;Xiao Fang Zhu","doi":"10.1111/jpi.70092","DOIUrl":"https://doi.org/10.1111/jpi.70092","url":null,"abstract":"<div>\u0000 \u0000 <p>Melatonin (MT) plays a critical role in regulating rice responses to heavy metal stress. However, the mechanism by which MT alleviates copper (Cu) toxicity in rice remains insufficiently understood. In this study, excessive Cu increased endogenous MT level in rice roots, accompanied by enhanced gene expression involved in MT biosynthesis, suggesting its role in Cu stress responses. Exogenous MT reduced Cu accumulation and restored root growth in rice under Cu stress, thereby mitigating Cu-induced phytotoxicity. Mechanistically, MT increased the root pectin content and its Cu retention, thereby reducing Cu influx into the cytoplasm. Additionally, exogenous MT upregulated the expression of <i>Heavy Metal ATPase 4</i> (<i>OsHMA4)</i> involved in vacuolar sequestration, as well as Cu efflux transporter genes <i>OsHMA6</i> and <i>OsHMA9</i>. Conversely, it downregulated the plasma membrane Cu uptake-associated genes <i>Copper Transporter</i> (<i>OsCOPT1</i>, <i>OsCOPT2</i>, and <i>OsCOPT3</i>), the vacuolar Cu exporter <i>OsCOPT7</i>, and the xylem loading transporter gene <i>OsHMA5,</i> thereby alleviating Cu toxicity in rice. Furthermore, MT elevated nitric oxide (NO) levels in root tips, and application of the exogenous NO scavenger, 2-(4-carboxyphenyl)−4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), attenuated the mitigative effect of MT on excess Cu-stressed rice. In summary, MT alleviates Cu toxicity by reducing Cu binding to root cell walls, thereby limiting Cu uptake and translocation from roots to shoots. This process may depend on NO accumulation and provides new insights into the molecular mechanisms underlying MT-induced Cu tolerance in rice.</p></div>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"77 6","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Microneedles by Pulsating In Situ Dried Electrostretching for Transdermal Drug Delivery (Small Methods 10/2025)","authors":"Ngoc Luan Mai,&nbsp;Yuen Yong,&nbsp;Thi Van Anh Hoang,&nbsp;Trung Hieu Vu,&nbsp;Hoai-Duc Vu,&nbsp;Van Canh Doan,&nbsp;Donglin Cai,&nbsp;Thien Xuan Dinh,&nbsp;Dzung Viet Dao,&nbsp;Van Thanh Dau","doi":"10.1002/smtd.70059","DOIUrl":"https://doi.org/10.1002/smtd.70059","url":null,"abstract":"<p><b>Transdermal Drug Delivery</b></p><p>In article number 2500183, Mai, Yong, Dau, and co-workers illustrate the mechanism of the state-of-the-art PIDES technique for microneedle fabrication. The novel method utilizes pulsed electrohydrodynamic force, generated through a parallel-plate electrode system, to transform polymeric droplets into microneedles, paving the way for next-generation transdermal drug delivery technologies.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 10","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}