Wiley最新文献

{"title":"Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy (Small 23/2025)","authors":"Lantian Wang,&nbsp;Zhaoyou Liu,&nbsp;Panpan Ji,&nbsp;Jiao Ma,&nbsp;Ke Mou,&nbsp;Tian Zhou,&nbsp;Yuan Liang,&nbsp;Bin Zhang,&nbsp;Mengying Wei,&nbsp;Guodong Yang,&nbsp;Wenqi Sun,&nbsp;Li Gong,&nbsp;Lijun Yuan","doi":"10.1002/smll.202570177","DOIUrl":"https://doi.org/10.1002/smll.202570177","url":null,"abstract":"<p><b>Immunotherapy</b></p><p>In article number 2405549, Wenqi Sun, Li Gong, Lijun Yuan, and co-workers have designed a nanodroplet for targeted PDL1 degradation in the tumor region. The nanodroplet is endowed with the capacities to accumulate in the ocean of tumor vessels and be visible by ultrasound, serving as a submarine. Moreover, ultrasound could launch the biorthogonal PD1 armed missiles on the “submarine”, and the missiles in turn lock onto PDL1 and destroy it to unleash anti-tumor immunity.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 23","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202570177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated Discovery of Solvation Structure Engineering for Stable Aqueous Rechargeable Zinc Batteries via Physics-Guided Bayesian Active Learning (Small 23/2025)","authors":"Minsu Kim,&nbsp;Minji Lee,&nbsp;Inyoung Choi,&nbsp;Jihye Oh,&nbsp;Sanga Paik,&nbsp;Areum Han,&nbsp;Sinae Lee,&nbsp;Hyerim Hwang,&nbsp;Jonggeol Na,&nbsp;Kwan Woo Nam","doi":"10.1002/smll.202570176","DOIUrl":"https://doi.org/10.1002/smll.202570176","url":null,"abstract":"<p><b>Aqueous Zinc Batteries</b></p><p>Aqueous zinc batteries, despite their advantages in safety and performance, suffer from water-based side reactions like hydrogen evolution and corrosion. In article number 2411632, Jonggeol Na, Kwan Woo Nam, and co-workers propose a novel electrolyte that enhances stability by suppressing these side reactions and maximizing performance through solvation structure optimization. In particular, it is noteworthy that only 26 experiments were conducted based on physics-guided Bayesian active learning.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 23","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202570176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Insights From Immunoreceptor Structures","authors":"T. Praveena,&nbsp;Jamie Rossjohn","doi":"10.1111/imr.70043","DOIUrl":"https://doi.org/10.1111/imr.70043","url":null,"abstract":"&lt;p&gt;Generation of immunity is a complex process orchestrated by various immune cells upon recognition of a diverse range of foreign molecules. It has two arms, namely innate and adaptive immunity. The former is the first responder that triggers a non-specific immune response and relies on various cells, including phagocytes, dendritic cells, and Natural Killer cells. The latter is an antigen-specific response and involves T cells and B cells. Innate immunity depends on pattern recognition receptors expressed on the surface of participating cells, including Toll-like receptors, Nod-like receptors, and C-type lectin receptors, whereas adaptive immunity involves specific cell surface receptors like T cell receptors and B antigen cell receptors.&lt;/p&gt;&lt;p&gt;The initial step in the adaptive immune response involves antigen-presenting cell binding, processing, and display of the antigens, which are then recognized by T and B cell antigen receptors, leading to the formation of antigen-receptor complexes on the cell surface. Decades of research have focused on understanding the intricate molecular-level details of this interaction, with the ultimate goal of designing therapeutics that target them. In this regard, structural biology has been an invaluable tool in providing the molecular blueprint of these ligand-receptor interactions.&lt;/p&gt;&lt;p&gt;In this special issue, 14 reviews have been written by leading research groups in the field. These detail the advancements emerging from structural studies, ranging from how T cell receptors (TCRs) become activated, antigen–antibody interactions, to understanding the SARS-CoV-2 receptor binding domain. This review addresses recent structural breakthroughs and concepts in T cell signaling and T cell biology, including unconventional T cells, namely γδ T cells, Mucosal-associated invariant T cells (MAIT cells), integrin receptors, and cytokine binding receptors. Collectively, a broad range of receptor-ligand interactions central to immunity are covered in this issue (Figure 1).&lt;/p&gt;&lt;p&gt;T cells play a crucial role in antigen-specific immune responses through their surface-expressed antigen receptors known as TCRs. They either belong to αβ or γδ T cell lineages, and comprise two chains with variable and constant domains that resemble an immunoglobulin architecture. In recent years, T cell-targeted therapies have shown promise for treating cancer, autoimmunity, and infectious diseases. Success in development of the therapeutics requires in-depth knowledge of receptor structure–function relationships as well as T cell biology. In line with this, Baker and his team [&lt;span&gt;1&lt;/span&gt;] highlight the importance of emerging TCRs that do not abide by the usual established recognition patterns based on structural information. Therefore, as TCR diversity continues to expand, it is paramount to have a thorough understanding of T cell immunity in order to fully harness the immunomodulatory potential of T cells. Davis and colleagues [&lt;span&gt;2&lt;/spa","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"332 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Feature: Unlocking the Potential of Tris(Pentafluorophenyl)Borane in Reductive Desulfurization of Thioamides With Silane","authors":"Pinaki Nad,&nbsp;Souvik Goswami,&nbsp;Hemanta K. Kisan,&nbsp;Arup Mukherjee","doi":"10.1002/chem.202583303","DOIUrl":"https://doi.org/10.1002/chem.202583303","url":null,"abstract":"<p><b>A B(C₆F₅)₃-catalyzed desulfurization</b> of thioamides in the presence of phenyl silane has been investigated. Interestingly, thioamides can undergo reduction via two pathways, viz., desulfurization and deamination. In their Research Article (DOI: 10.1002/chem.202500738), H. K. Kisan, A. Mukherjee and co-workers show that despite the possibilities of these two pathways, only one of them is operative selectively to provide the corresponding amines. In the same way, a car (thioamide) has the possibility to turn either right or left along the road; however, a policeman [B(C₆F₅)₃] helps the car to go in the right directions (desulfurization) to avoid the closed road on the left side.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":"31 33","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/chem.202583303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric Nanodroplet-Enhanced Ultrasound Surgery Combined with Immune Checkpoint Inhibition as a Cancer Therapy Platform (Small 23/2025)","authors":"Bar Glickstein,&nbsp;Mike Bismuth,&nbsp;Roni Gattegno,&nbsp;Tiran Bercovici,&nbsp;Oz Shaul,&nbsp;Ramona Aronovich,&nbsp;Galit Horn,&nbsp;Anat Globerson Levin,&nbsp;Yi Feng,&nbsp;Tali Ilovitsh","doi":"10.1002/smll.202570179","DOIUrl":"https://doi.org/10.1002/smll.202570179","url":null,"abstract":"<p>Cancer Therapy</p><p>In article number 2411474, Tali Ilovitsh and co-workers combine nanodroplet-mediated ultrasound surgery with checkpoint inhibition to enhance immunotherapy. Systemically injected nanodroplets accumulate in the tumor and are activated into cavitating gas bubbles using ultrasound imaging. Subsequent low-frequency ultrasound implodes the vaporized nanodroplets, inducing tumor fractionation and creating a T-cell–inflamed microenvironment. This approach integrates mechanical disruption with immune activation, addressing key barriers in solid tumor treatment.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 23","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202570179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Efficient Tri-Conductive Electrode for Ethane Direct Electrochemical Dehydrogenation on Proton Ceramic Electrolysis Cells (Small 23/2025)","authors":"Shixian Zhang,&nbsp;Wang Sun,&nbsp;Chunming Xu,&nbsp;Rongzheng Ren,&nbsp;Jinshuo Qiao,&nbsp;Zhenhua Wang,&nbsp;Kening Sun","doi":"10.1002/smll.202570182","DOIUrl":"https://doi.org/10.1002/smll.202570182","url":null,"abstract":"<p><b>Electrochemical Dehydrogenation</b></p><p>By optimizing the proton conductivity of anode with element doping Hf element enhanced electrochemical direct dehydrogenation of ethane to ethylene in proton ceramic electrolysis cell, achieving C₂H₆ conversion of 50.04% and C₂H₄ selectivity of ∼90% at 700°C. This work provides a new perspective for the conversion of light hydrocarbons to high value-added products. More in article number 2409452, Wang Sun, Kening Sun, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 23","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202570182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction (Adv. Sci. 22/2025)","authors":"Anqi Liu,&nbsp;Peng Peng,&nbsp;Changze Wei,&nbsp;Fanhui Meng,&nbsp;Xiaoyao Huang,&nbsp;Peisheng Liu,&nbsp;Siyuan Fan,&nbsp;Xinyue Cai,&nbsp;Meiling Wu,&nbsp;Zilin Xuan,&nbsp;Qing Liu,&nbsp;Xinyu Qiu,&nbsp;Zhenlai Zhu,&nbsp;Hao Guo","doi":"10.1002/advs.202570169","DOIUrl":"https://doi.org/10.1002/advs.202570169","url":null,"abstract":"<p><b>Apoptotic Vesicles-Based Cell-free Therapy</b></p><p>In article number 2407446, Hao Guo, Zhenlai Zhu, Xinyu Qiu, and colleagues introduce a novel therapeutic potential of apoptotic vesicles (ApoVs) for ameliorating hypersensitivity reactions through the induction of CD8⁺ T cell apoptosis. The cover illustrates that ApoVs derived from mesenchymal stem cells interact with CD8⁺ T cells via membrane fusion, triggering calcium influx, mitochondrial dysfunction, and ultimately apoptosis in CD8⁺ T cells. This study highlights the potential of products derived from apoptotic cells as a promising strategy for therapeutic applications in diseases involving CD8⁺ T cell-mediated pathologies. \u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 22","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge Distillation for Molecular Property Prediction: A Scalability Analysis (Adv. Sci. 22/2025)","authors":"Rahul Sheshanarayana,&nbsp;Fengqi You","doi":"10.1002/advs.202570174","DOIUrl":"https://doi.org/10.1002/advs.202570174","url":null,"abstract":"<p><b>Knowledge Distillation for Molecular Property Prediction</b></p><p>This illustration shows how AI distills rich molecular insights from complex teacher models into compact student models, enabling accurate, scalable prediction of both experimental and quantum mechanical properties—advancing molecular design and discovery across domains. More details can be found in article number 2503271 by Rahul Sheshanarayana and Fengqi You.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 22","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of Core-Shell Structured Magnetic Microwire with Desirable Properties for Multifunctional Applications (Small 23/2025)","authors":"Si-Da Jiang,&nbsp;Tatiana Eggers,&nbsp;Ongard Thiabgoh,&nbsp;Chen Wang,&nbsp;Jun-Tao Huo,&nbsp;Zhi-Liang Ning,&nbsp;Hong-Xian Shen,&nbsp;Jian-Fei Sun,&nbsp;Manh-Huong Phan","doi":"10.1002/smll.202570181","DOIUrl":"https://doi.org/10.1002/smll.202570181","url":null,"abstract":"<p><b>Microwires</b></p><p>In article number 2500455, Si-Da Jiang and co-workers produce innovative nanocrystal-core/amorphous-shell structure directly from as-quenched amorphous microwire (CoFe-Based) by using a multi-step direct current annealing technique. It possesses enhanced mechanical, soft magnetic and giant magneto-impedance properties that fulfil the requirements of the emerging sensor technologies. It can be applied to weak magnetic sensors and self-monitoring sensors.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 23","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202570181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Task-Evoked Theta Oscillation Dysregulation Underlies Attention Network Deficits in Left Temporal Lobe Drug-Resistant Epilepsy","authors":"Changqing Zhan,&nbsp;Qiao Wang,&nbsp;Wenyu Wang,&nbsp;Na Pan,&nbsp;Jieju Feng,&nbsp;Zonghan Yang,&nbsp;Shizao Fei,&nbsp;Zongsheng Chen,&nbsp;Yingnian Chen","doi":"10.1111/cns.70450","DOIUrl":"https://doi.org/10.1111/cns.70450","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study investigated the neural mechanisms of left temporal lobe drug-resistant epilepsy (DRE) with attention network dysfunction using the attention network test (ANT) and synchronous electroencephalography (EEG).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study enrolled three cohorts: 20 patients with left temporal lobe drug-resistant epilepsy (DRE group), 20 left temporal lobe drug-sensitive epilepsy (DSE group) patients, and 20 age-/sex-matched healthy controls (Ctrl group). Participants completed standardized ANT tasks while scalp EEG was recorded at a 1000 Hz sampling rate. We computed power spectral density (PSD) of neural oscillations from ANT-task EEG epochs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>DRE patients exhibited significantly impaired network efficiency across executive control (EC), alerting, and orienting networks. Compared to the Ctrl group, both DRE and DSE groups demonstrated reduced frontal theta PSDs in EC, alerting, and orienting networks (all <i>p</i> &lt; 0.001), with the DRE group showing greater deficits than the DSE group in the EC network (<i>p</i> &lt; 0.001). Additionally, Significant correlations emerged between frontal theta PSD and behavior in Ctrl (EC_{_effect}: <i>r</i> = −0.659, <i>p</i> = 0.002; Alerting_{_effect}: <i>r</i> = 0.690, <i>p</i> = 0.001; Orienting_{_effect}: <i>r</i> = 0.649, <i>p</i> = 0.002) and DSE (EC_{_effect}: <i>r</i> = −0.595, <i>p</i> = 0.006; Alerting_{_effect}: <i>r</i> = 0.592, <i>p</i> = 0.006; Orienting_{_effect}: <i>r</i> = 0.588, <i>p</i> = 0.006). In the DRE group, however, The theta band PSDs of the attention network show no significant correlation with behavioral response effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Drug-resistant epilepsy patients have dysfunctional attention network behavior and decreased theta band PSDs in the frontal lobe. It is possible that decreased theta oscillations in the frontal lobe may contribute to ANT behavior dysfunction in drug-resistant epilepsy patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 6","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}