Wiley最新文献

{"title":"Impact of the addition of antithymocyte globulin to post-transplantation cyclophosphamide in haploidentical transplantation with peripheral blood compared to post-transplantation cyclophosphamide alone: A retrospective study on behalf of the Cellular Therapy and Immunobiology Working Party of the European Society for Blood and Marrow Transplantation.","authors":"Antoine Capes, Jarl E Mooyaart, Didier Blaise, Stefania Bramanti, Mi Kwon, Mohamad Mohty, Patrice Chevallier, Jan Vydra, Péter Reményi, Edouard Forcade, Lucía López Corral, Maija Itälä-Remes, Ali Bazarbachi, Enrico Derenzini, Jorinde D Hoogenboom, Jürgen Kuball, Giorgia Battipaglia, Florent Malard, Annalisa Ruggeri","doi":"10.1111/bjh.70050","DOIUrl":"https://doi.org/10.1111/bjh.70050","url":null,"abstract":"<p><p>In the setting of haploidentical haematopoietic cell transplantation (HCT), post-transplant cyclophosphamide (PTCy) has dramatically reduced the incidence of graft-versus-host disease (GVHD) and non-relapse mortality. To further reduce GVHD incidence, the addition of antithymocyte globulin (ATG) to PTCy was evaluated in retrospective and non-comparative prospective studies showing promising results. We conducted a large retrospective analysis of the European Society for Blood and Marrow Transplantation (EBMT) registry to evaluate this approach. We analysed haploHCT with peripheral blood stem cells performed for haematological malignancies between 2014 and 2021. GVHD prophylaxis included either PTCy alone or PTCy+ATG. Four thousand five hundred and nineteen patients were analysed in the PTCy only group versus 675 with PTCy+ATG. Median follow-up was 29.80 months. In univariate analysis, 2-year GVHD-free, relapse-free survival (GRFS), relapse-free survival (RFS), overall survival (OS), cumulative incidence of relapse, non-relapse mortality (NRM) and chronic GvHD (cGVHD) were, respectively: 40.5% versus 37.5% (p = 0.098), 50.9% versus. 45.8% (p = 0.015), 56.9% versus 52.5% (p = 0.01), 24.2% versus 28.1% (p = 0.032), 25% versus 26.1% (p = 0.49) and 28.4% versus 18.5% (p < 0.001). aGVHD did not differ. After multivariable adjustment, OS and RFS were lower in the PTCy+ATG group: HR = 1.18 (p = 0.037) and HR = 1.18 (p = 0.027) and patients receiving PTCy+ATG had less cGVHD: HR = 0.68 (p = 0.004). In that retrospective analysis, the addition of ATG to PTCy for GVHD prophylaxis in haploHCT was associated with a reduction of cGVHD but also a worse OS and RFS.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ion-Pairing Assemblies of Polarized Charged Porphyrin.","authors":"Ryo Kitayama, Yohei Haketa, Yuto Maruyama, Masaki Fujita, Hiroki Tanaka, Hiroki Horita, Hiromitsu Maeda","doi":"10.1002/chem.202502225","DOIUrl":"https://doi.org/10.1002/chem.202502225","url":null,"abstract":"<p><p>A porphyrin Au^III complex comprising 5,10-penatafluorophenyl units was synthesized as a dipolar π-electronic cation. The π-electronic cation was combined with anions, including a bulky borate anion and planar π-electronic anions. The dipolar π-electronic cation formed crystal-state ion-pairing assemblies based on antiparallel stacking structures, which were stabilized by interionic dipole-dipole interactions.</p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e02225"},"PeriodicalIF":3.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opinion: Why Sex-Based Genomic Differentiation Should Not Be Overlooked in Population Genetics.","authors":"Yu-Chi Chen, Nikolas Vellnow, Justin J S Wilcox, Sahar Javaheri Tehrani, Toni I Gossmann","doi":"10.1111/mec.70061","DOIUrl":"https://doi.org/10.1111/mec.70061","url":null,"abstract":"<p><p>Sex-specific genomic differentiation is a crucial yet frequently overlooked factor in population genetics. In this opinion piece, we leverage the substantial genomic resources available for the great tit (Parus major), including population-scale data sets from many European populations, to investigate genomic differentiation between males and females. Unlike in some other species, where high-quality genome assemblies exist but broad population sampling is lacking, the great tit offers a unique opportunity to study sex-based differentiation at both the genomic and population level. We identify significant differentiation at an autosomal locus on chromosome 5, which we hypothesise originates from sex-linked variation present on the sex chromosomes (Z and potentially W). By referencing genomic data from other songbirds with well-assembled sex chromosomes, we illustrate how autosomal loci may exhibit high sequence similarity to sex-linked regions. Our analyses demonstrate that uneven sex ratios in sampled populations can substantially bias differentiation metrics (e.g., F_ST), potentially resulting in false-positive interpretations of adaptive differentiation. To mitigate such issues, we stress the importance of sex-aware study designs, including balanced sex sampling and explicitly incorporating sex as a covariate. Furthermore, while optimal study designs would include high-quality reference genomes from both sexes, we recommend, as a pragmatic and cost-effective alternative for labs with limited resources, generating a reference genome from the heterogametic sex (females in birds) to ensure both sex chromosomes are represented in mapping and analysis. Finally, we emphasise the need for rigorous validation of candidate loci to ensure accurate and biologically meaningful outcomes in evolutionary genomic studies.</p>","PeriodicalId":210,"journal":{"name":"Molecular Ecology","volume":" ","pages":"e70061"},"PeriodicalIF":3.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid Shear-Controlled Pro/Anti-Inflammatory Osteomodulatory Construct for Drug-Free Immune Activation Through Cationic Ion Channel Activation.","authors":"Keya Ganguly, Aayushi Randhawa, Sayan Deb Dutta, Jieun Lee, Youjin Seol, Mehran Mohammad Hossein Pour, Tejal V Patil, Rumi Acharya, Ki-Taek Lim","doi":"10.1002/adhm.202500404","DOIUrl":"https://doi.org/10.1002/adhm.202500404","url":null,"abstract":"<p><p>Effective bone regeneration requires the integration of immune and mechanical signals, which current biomaterials often fail to achieve. To address this, an immunomodulatory scaffold is developed combining 3D printing and electrospinning, designed to mimic the bone and periosteum. The scaffold features an outer electrospun nanofiber mat and an inner 3D-printed core, creating a biomimetic structure that facilitates the polarization of macrophages into pro-inflammatory (M1) and anti-inflammatory (M2) states under physiological fluid shear stress (FSS). RNA sequencing revealed the pivotal role of ion channels, particularly potassium channels, in the dynamic polarization of macrophages. The scaffold also supports mesenchymal stem cell-driven osteogenesis, establishing a synergistic environment for bone repair. This dual-function scaffold holds promise for enhancing tissue regeneration, especially in immune-compromised conditions, by integrating mechanotransduction and immune modulation within a single platform. Our findings provide a novel approach to overcoming the limitations of existing biomaterials and expanding their applications in regenerative medicine.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00404"},"PeriodicalIF":9.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Risk of Cerebral Arteriovenous Malformation Rupture during Pregnancy and Puerperium.","authors":"Haibin Zhang, Heze Han, Yuqing Jiao, Yahui Zhao, Li Ma, Ruinan Li, Zhipeng Li, Anqi Li, Kexin Yuan, Qinghui Zhu, Chengzhuo Wang, Yukun Zhang, Junlin Lu, Debin Yan, Dezhi Gao, Geng Guo, Xun Ye, Youxiang Li, Shibin Sun, Hao Wang, Yuanli Zhao, Yu Chen, Rong Wang, Limin Feng, Xiaolin Chen","doi":"10.1002/ana.70014","DOIUrl":"https://doi.org/10.1002/ana.70014","url":null,"abstract":"<p><strong>Objective: </strong>Cerebral arteriovenous malformations (AVM) pose a significant risk during pregnancy because of hormonal changes and increased hemodynamic stress. This study aims to assess the risk of AVM rupture during pregnancy and puerperium and to identify risk factors associated with rupture.</p><p><strong>Methods: </strong>This prospective cohort study included 588 women with AVMs and a history of pregnancy, enrolled from a nationwide registry in China between August 2011 and August 2021. A case-crossover design was used to compare rupture risk during pregnancy, puerperium, and non-pregnancy periods, adjusting for clinical and morphological factors. Multivariable logistic regression analysis identified independent risk factors.</p><p><strong>Results: </strong>The risk of AVM rupture was significantly higher during pregnancy compared to non-pregnancy periods (4.5% vs 1.6%; risk ratio [RR], 3.1; 95% confidence interval [CI], 2.3-4.2; p < 0.001). The risk was particularly elevated during the second and third trimesters. Key factors independently associated with increased rupture risk included adolescent or advanced-age pregnancy (adolescent ≤19 years or advanced ≥35 years, odds ratio [OR], 8.32; 95% CI, 2.09-28.12, p = 0.001), a history of AVM rupture before pregnancy (OR, 4.20; 95% CI, 1.37-11.40; p = 0.007), diffuse nidus (OR, 2.32; 95% CI, 1.07-5.12; p = 0.033), and multifetal pregnancy (OR 18.31; 95% CI, 1.14-293.27; p = 0.040).</p><p><strong>Interpretation: </strong>Pregnancy substantially increases the risk of AVM rupture, particularly during the second and third trimesters and compared to pre-first pregnancy periods. Risk factors such as adolescent or advanced-age pregnancy and multifetal pregnancy further increase the risk. These findings underscore the importance of tailored management during pregnancy for optimizing maternal and fetal outcomes. ANN NEUROL 2025.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion and Surface Effects on Sodium-Promoted MoS₂ Growth Observed in Operando.","authors":"Jehyun Oh, Yoonbeen Kang, Jae Hun Seol, Yong Hui Kim, Jinyoung Seo, Sang Uck Lee, Sang-Yong Ju","doi":"10.1002/smtd.202500813","DOIUrl":"https://doi.org/10.1002/smtd.202500813","url":null,"abstract":"<p><p>Understanding precursor diffusion and substrate interaction is key to advancing chemical vapor deposition (CVD) of transition metal dichalcogenides (TMCs), yet direct observation has remained a challenge due to limited real-time observation. Here, MoS₂ growth is directly monitored to investigate the kinetics and influence of the precursor/sodium droplet eutectic (SODE). Serving as a catalyst, SODE migrates from the basal plane to the edges and substrate interface, promoting growth and enabling grain translation and rotation. Kinetic analysis shows MoS₂ grows more readily on its own surface than on SiO₂, indicating a thermodynamic-kinetic interplay supported by density functional theory calculations. Notably, larger SODE droplets enhance such grain dynamics, while submicron-scale SODE exhibits extended diffusion, enabling uniform, large-area growth. These findings highlight the critical role of molten metal diffusion in growth continuity and provide new insights for optimizing scalable, cost-effective TMC fabrication.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e00813"},"PeriodicalIF":9.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized Reduced Graphene Oxide-Based Nanocomposite Hydrogels for Enhanced Osteogenesis in Bone Tissue Engineering.","authors":"George Mihail Vlăsceanu, Cătălina Ionela Zamfir, Cornel Baltă, Hildegard Herman, Alina Ciceu, Maria Alexandra Duma, Mariana Ioniță, Roxana-Cristina Popescu, Anca Hermenean","doi":"10.1002/adhm.202501941","DOIUrl":"https://doi.org/10.1002/adhm.202501941","url":null,"abstract":"<p><p>This study presents the development of nanocomposite hydrogels that integrate functionalized reduced graphene oxide (rGO) derivatives carboxylated (CBX) and aminated (AMN) in combination with gellan gum, gelatin, and cellulose nanofibrils (CNFs) to enhance osteogenesis for bone tissue engineering. Their synthesis involves ultrasound exfoliation, genipin crosslinking, and freeze-drying. Micro-computed tomography (µCT) reveals highly porous, interconnected architectures facilitating nutrient diffusion and cell infiltration. CBX/AMN scaffolds exhibit superior hydration capacity and a biphasic degradation profile. Spectroscopically, enhanced interfacial interactions were confirmed, contributing to the overall structural stability of the hydrogels. In vitro, all scaffolds are cytocompatible, sustain cell viability, and promote osteogenic differentiation consistent with adaptive cellmaterial interactions. Subcutaneous implantation in mice confirms scaffold biocompatibility, showing no signs of inflammation or foreign body response. Histological and immunofluorescence analyses reveal osteogenic potential, with enhanced mineralization and elevated expression of osteopontin and osteocalcin. µCT imaging of explants quantifies ectopic mineralization, spatial deposition patterns, and bone mineral density, correlating scaffold architecture and composition with osteogenic performance. These findings suggest that the synergistic integration of functionalized rGO, CNFs, and biopolymers results in scaffolds with enhanced structural and biological properties, highlighting their potential for design optimization and clinical translation in bone regenerative medicine.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01941"},"PeriodicalIF":9.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface Chemistry Stabilization by Esterification of Polypropylene Treated by Direct Fluorination.","authors":"Nicolas Suchet, Nicolas Batisse, Marc Dubois, Béatrice Guieu, Frédéric Sanquer","doi":"10.1002/cplu.202500128","DOIUrl":"https://doi.org/10.1002/cplu.202500128","url":null,"abstract":"<p><p>Direct fluorination, based on a gas/solid reaction with elemental fluorine F₂, is a surface treatment that is able to modify the superficial properties of polymers, like surface energy or tribological behavior. Nevertheless, side reactions occur with oxygen either present in the reactive molecular fluorine gas (F₂) or during a post-reaction when the sample is exposed to air atmosphere. A systematic study of the fluorination of polypropylene at different temperatures identifies the formation of acyl fluoride COF groups, coexisting with the fluorinated groups. COF groups evolve into carboxylic acid (COOH) groups during the first few hours after fluorination. Despite the presence of fluorine, the polar component of the surface energy increased. By introducing an esterification post-treatment of the COF groups with an alcohol in the gas phase after the fluorination step, it is possible to stabilize the surface chemistry and thus prevent its hydrolysis. Surfaces post-treated by this singular approach are less hydrophilic than their counterparts only treated by direct fluorination.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202500128"},"PeriodicalIF":2.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging reveals distinct cardiac benefits of dulaglutide versus dapagliflozin in a mouse model of glucotoxic cardiomyopathy.","authors":"Michael Joubert, Simon Ducheix, Xavier Prieur, Bertrand Cariou, Alain Manrique","doi":"10.1111/dom.70012","DOIUrl":"https://doi.org/10.1111/dom.70012","url":null,"abstract":"","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrothermal Carbonaceous Nanospheres as Emerging Candidates for High-Performance Chemi-Resistive NO₂ Gas Sensing.","authors":"Seonyeop Kim, Hossein Fattahimoghaddam, Yong-Wook Jeong, Jaehee Yeom, Tae Kyu An, Wonseok Lee, Yong Jin Jeong","doi":"10.1002/smtd.202501005","DOIUrl":"https://doi.org/10.1002/smtd.202501005","url":null,"abstract":"<p><p>Chemiresistive gas sensors have garnered increasing attention due to their critical role in environmental monitoring, industrial safety, and public health. Recently, metal-free carbon-based polymeric semiconductors have emerged as promising, offering advantages in processability, stability, and functional tunability. Building on this approach, hydrothermal carbonaceous nanospheres (HC-NSs) are designed as a new class of high-performance sensing materials for NO₂ detection. HC-NSs, synthesized via a one-step hydrothermal process, possess a conjugated sp²-hybridized carbon backbone decorated with oxygen-rich functional groups and exhibit a high specific surface area and mesoporous structure, offering abundant active sites and efficient gas diffusion pathways for enhanced sensing performance. These features endow the material with p-type semiconducting behavior and high surface reactivity, resulting in an impressive gas response of -74.4% toward 50 ppm NO₂ and a low detection limit of 80.6 ppb. Comparative analysis with benchmark tellurium nanowires highlights the superior sensitivity, selectivity, and environmental robustness of HC-NSs. The nanospheres maintain consistent sensing performance under wide-ranging humidity (20-80% RH) and elevated temperatures (up to 200 °C), demonstrating their resilience and reliability in diverse operating environments. The enhanced performance is attributed to the synergistic effects of oxygenated surface groups and sp² carbon network, which promote efficient NO₂ adsorption and charge transfer.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e01005"},"PeriodicalIF":9.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}