综合性期刊最新文献

{"title":"Cultural heritage in climate planning: An analysis of the Norwegian national climate documents and guidelines","authors":"Paloma Guzman","doi":"10.1016/j.culher.2025.05.003","DOIUrl":"10.1016/j.culher.2025.05.003","url":null,"abstract":"<div><div>Cultural heritage management is increasingly recognized as integral to climate action and sustainable development. Yet, limited research has explored how sociocultural elements are operationalized within coherent climate strategies. This paper proposes an analytical framework to evaluate the integration of cultural heritage within climate policy discourses, tested through a case study of twenty Norwegian national climate policy documents. Applying transformative approaches to climate governance, this study emphasizes cultural heritage management’s role in supporting systemic change. The framework identifies two primary shifts in policy discourse driven by cultural heritage paradigms: (1) integration across three stages—from visions and actions to monitoring—and (2) expanded sectoral collaboration, opening pathways for transformative governmental coordination. Findings reveal an evolution in cultural heritage’s role, from initial concerns about conservation conflicts due to climate impacts to recognizing cultural heritage as a sector requiring knowledge-building in adaptation strategies. The analysis further suggests an expanded view of cultural heritage’s contribution to the quality of life through shared sociocultural values, highlighting opportunities to extend its role from technical advisor to a strategic, relational actor within governance networks. By examining the case of Norway, this study concretizes entry points for cultural heritage’s potential as a catalyst for cross-sectoral collaboration, adaptive governance, and inclusive decision-making, setting a foundation for exploring local-level integration and interdisciplinary collaboration in sustainability governance.</div></div>","PeriodicalId":15480,"journal":{"name":"Journal of Cultural Heritage","volume":"74 ","pages":"Pages 35-47"},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma","authors":"Lanjuan Mi, Yan Cai, Ji Qi, Lishu Chen, Yuanyuan Li, Songyang Zhang, Haowen Ran, Qinghui Qi, Cheng Zhang, Huiran Wu, Shuailiang Cao, Haohao Huang, Dake Xiao, Xinzheng Wang, Bohan Li, Jiong Xie, Fangye Li, Qiuying Han, Qiulian Wu, Tao Li, Ailing Li, Jeremy N. Rich, Tao Zhou, Jianghong Man","doi":"10.1038/s41467-025-60228-z","DOIUrl":"https://doi.org/10.1038/s41467-025-60228-z","url":null,"abstract":"<p>Glioblastoma (GB) is a highly aggressive brain tumor resistant to chemoradiotherapy, largely due to glioma stem-like cells (GSCs) with robust DNA damage repair capabilities. Here we reveal that GSCs enhance their DNA repair capacity by activating non-homologous end-joining (NHEJ) through upregulation of the apoptosis antagonizing transcription factor (AATF), thereby promoting therapeutic resistance in GB. AATF interacts with XRCC4, a core NHEJ subunit, preventing its degradation via ubiquitin-mediated proteasomal processes. Upon DNA damage, AATF undergoes phosphorylation at Ser189 by ATM, leading to its dissociation from XRCC4 and rapid recruitment of XRCC4 to DNA break sites for efficient NHEJ repair. Moreover, AATF depletion or deficient AATF phosphorylation impedes NHEJ in GSCs, sensitizing GB xenografts to chemoradiotherapy. Additionally, elevated levels of AATF inform poor prognosis in GB patients. Collectively, our findings unveil a crucial role of AATF in XRCC4-mediated NHEJ repair, and underscore targeting AATF as a potential strategy to overcome GB resistance to chemoradiotherapy.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper-catalyzed enantioselective three-component radical 1,4-perfluoroalkylamination of 1,3-dienes","authors":"Xiaoyan Shangguan, Lihan Zhu, Yingzi Zhang, Yan Li, Qian Zhang","doi":"10.1038/s41467-025-60227-0","DOIUrl":"https://doi.org/10.1038/s41467-025-60227-0","url":null,"abstract":"<p>Catalytic enantioselective three-component aminative difunctionalization of readily available 1,3-dienes offers a straightforward methodology to fast access significant and complex chiral allylic amines. Nevertheless, compared to the widely studied two-component reactions, the three-component reactions, especially using anilines—very common bulk feedstock chemicals as aminating reagents are underdeveloped. More importantly, the limited examples of enantioselective three-component aminative difunctionalization of 1,3-dienes with anilines only showed 1,2-selectivity; and the corresponding 1,4-regioselectivity remains unknown. Here, we report a copper-catalyzed enantioselective radical three-component 1,4-perfluoroalkylamination of 1,3-dienes with anilines and perfluoroalkyl reagents, efficiently providing an array of valuable perfluoroalkylated chiral allylic amines in good to excellent yields with excellent enantioselectivity. Mechanistic investigations, including controlled experiments and DFT studies, elucidate the origination of the regioselectivity and enantioselectivity, and suggest a radical reaction pathway involving an asymmetric cross-coupling between allylic radical and copper-stabilized nitrogen radical species to construct C–N bond enantioselectively.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity","authors":"Alissa J. Trzeciak, Zong-Lin Liu, Mohamed Gatie, Adam S. Krebs, Waleska Saitz Rojas, Anya J. O’Neal, Ann K. Baako, Zhaoquan Wang, Justin Nelson, Isabella C. Miranda, Jazib Uddin, Allie Lipshutz, Jian Xie, Chou-Long Huang, Pedro H. V. Saavedra, Anna-Katerina Hadjantonakis, Michael Overholtzer, Michael S. Glickman, Arohan R. Subramanya, Thomas Vierbuchen, Jon Iker Etchegaray, Christopher D. Lucas, Christopher N. Parkhurst, Justin S. A. Perry","doi":"10.1038/s41467-025-59901-0","DOIUrl":"https://doi.org/10.1038/s41467-025-59901-0","url":null,"abstract":"<p>Tissue-resident macrophages (TRM) are critical for mammalian organismal development and homeostasis. Here we report that with-no-lysine 1 (WNK1) controls myeloid progenitor fate, with <i>Csf1r</i>^iCre-mediated <i>Wnk1</i> deletion in mice (WNK1-deficient mice) resulting in loss of TRMs and causing perinatal mortality. Mechanistically, absence of WNK1 or inhibition of WNK kinase activity disrupts macrophage colony-stimulating factor (M-CSF)-stimulated macropinocytosis, thereby blocking mouse and human progenitor and monocyte differentiation into macrophages and skewing progenitor differentiation into neutrophils. Treatment with PMA rescues macropinocytosis but not macrophage differentiation of WNK-inhibited progenitors, implicating that M-CSF-stimulated, macropinocytosis-induced activation of WNK1 is required for macrophage differentiation. Finally, M-CSF-stimulated macropinocytosis triggers WNK1 nuclear translocation and concomitant increased protein expression of interferon regulatory factor (IRF)8, whereas inhibition of macropinocytosis or WNK kinase activity suppresses IRF8 expression. Our results thus suggest that WNK1 and downstream IRF8-regulated genes are important for M-CSF/macropinocytosis-mediated regulation of myeloid cell lineage commitment during TRM development and homeostasis.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Archaeology field notebook","authors":"","doi":"10.1038/d41586-025-01579-x","DOIUrl":"https://doi.org/10.1038/d41586-025-01579-x","url":null,"abstract":"Digging for clues.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"89 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bed bugs boomed as the world’s first cities did","authors":"","doi":"10.1038/d41586-025-01644-5","DOIUrl":"https://doi.org/10.1038/d41586-025-01644-5","url":null,"abstract":"Genomic evidence suggests that the bloodsuckers might have been among the first urban insect pests.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"3 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘A funeral for our careers’: Trump’s science cuts spill onto Canadian turf","authors":"","doi":"10.1038/d41586-025-01439-8","DOIUrl":"https://doi.org/10.1038/d41586-025-01439-8","url":null,"abstract":"Researchers in Canada prepare for turbulence in the wake of US funding changes — but there’s a silver lining.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"58 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating small area population from health intervention campaign surveys and partially observed settlement data","authors":"Chibuzor Christopher Nnanatu, Amy Bonnie, Josiah Joseph, Ortis Yankey, Duygu Cihan, Assane Gadiaga, Hal Voepel, Thomas Abbott, Heather R. Chamberlain, Mercedita Tia, Marielle Sander, Justin Davis, Attila N. Lazar, Andrew J. Tatem","doi":"10.1038/s41467-025-59862-4","DOIUrl":"https://doi.org/10.1038/s41467-025-59862-4","url":null,"abstract":"<p>Effective governance requires timely and reliable small area population counts. Geospatial modelling approaches which utilise bespoke microcensus surveys and satellite-derived settlement maps and other spatial datasets have been developed to fill population data gaps in countries where censuses are outdated and incomplete. However, logistics and costs of microcensus surveys and tree canopy or cloud cover obscuring settlements in satellite images limit its wider applications in tropical rural settings. Here, we present a two-step Bayesian hierarchical modelling approach that can integrate routinely collected health intervention campaign data and partially observed settlement data to produce reliable small area population estimates. Reductions in relative error rates were 32–73% in a simulation study, and ~32% when applied to malaria survey data in Papua New Guinea. The results highlight the value of demographic data routinely collected through health intervention campaigns or household surveys for improving small area population estimates, and how biases introduced by satellite data limitations can be overcome.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"82 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary income inequality outweighs historic redlining in shaping intra-urban heat disparities in Los Angeles","authors":"Anamika Shreevastava, Glynn Hulley, Sai Prasanth, TC Chakraborty, Diego Ramos Aguilera, Kelly Twomey Sanders, Yi Yin","doi":"10.1038/s41467-025-59912-x","DOIUrl":"https://doi.org/10.1038/s41467-025-59912-x","url":null,"abstract":"<p>The roots of intra-urban heat disparity in the U.S. often trace back to historical discriminatory practices, such as redlining, which categorized neighborhoods by race or ethnicity. In this study, we compare the relative impacts of historic redlining and current income inequality on thermal disparities in Los Angeles. A key innovation of our work is the use of land surface temperature data from the ECOSTRESS instrument aboard the International Space Station, enabling us to capture diurnal trends in urban thermal disparities. Our findings reveal that present-day income inequality is a stronger predictor of heat burden than the legacy of redlining. Additionally, land surface temperature disparities exhibit a seasonal hysteresis effect, intensifying during extreme heat events by 5−7 °C. Sociodemographic analysis highlights that African-American and Hispanic populations in historically and economically disadvantaged areas are often the most vulnerable. Our findings suggest that while the legacy of redlining may persist, the present-day heat disparities are not necessarily an immutable inheritance, where targeted investments and interventions can pave the way for a more thermally just future for these communities.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The perfect storm for dust storms, thanks to global warming","authors":"","doi":"10.1038/d41586-025-01654-3","DOIUrl":"https://doi.org/10.1038/d41586-025-01654-3","url":null,"abstract":"Climate change is lengthening the gap between snowmelt and vegetation growth.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"35 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}