Science Advances最新文献

Spatial reorganization of object representations in high-level visual cortex distinguishes working memory from perception 高阶视觉皮层中物体表征的空间重组是工作记忆与知觉的区别

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08

Wanru Li, Jia Yang, Pinglei Bao

{"title":"Spatial reorganization of object representations in high-level visual cortex distinguishes working memory from perception","authors":"Wanru Li, Jia Yang, Pinglei Bao","doi":"","DOIUrl":"","url":null,"abstract":"<div >The visual system balances veridical object perception with flexible visual working memory (VWM), both engaging high-level visual regions. However, how these competing demands shape object-selective cortex (OSC) representations remains unclear. Here, we ask whether VWM inherits the spatial constraints observed in the OSC during perception or reorganizes representations to meet mnemonic demands. Using a matched task design and functional magnetic resonance imaging–based decoding, we systematically compared the localization of object-identity representations during perception and VWM. A robust dissociation emerged: Perception kept object information largely contralateral, whereas VWM produced robust ipsilateral representation even when memorizing bilateral items. These expanded representations exploited more than 90% of ipsilateral OSC vertices and could not be attributed to increased attentional span. Critically, the ipsilateral representations closely mirrored contralateral representations, implicating interhemispheric coordination in VWM. Together, these findings demonstrate that object VWM flexibly recruits distributed high-level visual cortex, with spatial reorganization distinguishing mnemonic flexibility from perceptual fidelity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 19","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curvature-programmed nitrate electroreduction via single-atom protrusions on quantum dots 量子点上单原子突起的曲率编程硝酸电还原

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08

Dong Chen, Shaoce Zhang, Dongchang He, Haifan Li, Xinru Yang, Di Yin, Mengxue Chen, Quan Quan, Yuxuan Zhang, Boxiang Gao, Yi Shen, Weijun Wang, Zenghui Wu, You Meng, SenPo Yip, Chun-Yuen Wong, Chunyi Zhi, Johnny C. Ho

{"title":"Curvature-programmed nitrate electroreduction via single-atom protrusions on quantum dots","authors":"Dong Chen, Shaoce Zhang, Dongchang He, Haifan Li, Xinru Yang, Di Yin, Mengxue Chen, Quan Quan, Yuxuan Zhang, Boxiang Gao, Yi Shen, Weijun Wang, Zenghui Wu, You Meng, SenPo Yip, Chun-Yuen Wong, Chunyi Zhi, Johnny C. Ho","doi":"","DOIUrl":"","url":null,"abstract":"<div >Local geometric constraints have a substantial influence on electronic structure renormalization, offering a promising approach to enhance single-atom catalysts (SACs) beyond traditional limits. Conventional SACs typically feature planar-confined sites, but three-dimensional configurations remain underexplored. This study introduces a “curvature-programming” strategy to drive electrochemical nitrate reduction by assembling FeCu dual single-atom protrusions on molybdenum carbide quantum dots (FeCu/MoCx-5 QDs). The high-curvature QDs and protruding geometries mimic active vertex sites, enhancing electric fields to polarize N─O bonds. This delivers nearly 100% NH3 Faradaic efficiency over a wide potential window (−0.1 to −0.4 V versus reversible hydrogen electrode), with an ultralow overpotential (300 mV) and energy consumption (7.52 Wh gNH3−1 mgcat−1). FeCu/MoCx-5 effectively reduces nitrate levels in wastewater, producing scalable (NH4)2SO4, thus integrating environmental remediation with renewable energy storage. This work provides a promising strategy for developing SACs for broader energy applications.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 19","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchical brain dynamics supporting visual perceptual transitions 支持视觉感知转换的分层大脑动力学

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08

Max Levinson, Alice E. Waitt, Katharina Duecker, Syanah C. Wynn, Ole Jensen, Sylvain Baillet

{"title":"Hierarchical brain dynamics supporting visual perceptual transitions","authors":"Max Levinson, Alice E. Waitt, Katharina Duecker, Syanah C. Wynn, Ole Jensen, Sylvain Baillet","doi":"","DOIUrl":"","url":null,"abstract":"<div >A longstanding debate in consciousness research concerns whether subjective perceptual experiences arise primarily from activity in sensory cortices or rely critically on inferences made in higher-order brain regions. We address this question using a compelling visual illusion (perceptual filling-in) that isolates neural processes underlying transitions from veridical to illusory conscious experience. Using whole-brain magnetoencephalographic imaging and rapid invisible frequency tagging, we tracked cortical dynamics during filling-in and assessed their modulation by microsaccadic eye movements, which are known to delay the illusion. We found that transitions in conscious perception involved two dissociable mechanisms: (i) boundary fading in visual cortex, reflected by increased excitability and reduced alpha-band activity, consistent with a shift in excitation-inhibition balance, and (ii) higher-order perceptual monitoring processes involving motor cortex, indexed by decreased high-alpha and beta-band activity. Microsaccades selectively reset both processes. These findings support a hierarchical framework in which visual and motor systems jointly shape transitions in conscious visual experience.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 19","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantio- and regioselective nickel/photoredox-catalyzed cross-electrophile coupling of benzylic aziridines with alkynyl bromides 对映和区域选择性镍/光氧化还原催化的苯基叠氮嘧啶与炔基溴的交叉亲电偶联

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08

Hongyan Lan, Zhao-Dong Xu, Zhuangzhi Shi, Lutz Ackermann, Dingyi Wang

引用次数: 0

Erratum for the Research Article "A splenic-targeted versatile antigen courier: iPSC wrapped in coalescent erythrocyte-liposome as tumor nanovaccine" by Y. Zhai et al. Y. Zhai等人的研究文章《一种脾脏靶向的多功能抗原信使：聚结红细胞脂质体包裹的iPSC作为肿瘤纳米疫苗》的勘误

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08 DOI: 10.1126/sciadv.aei1515

引用次数: 0

PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity. PARP2缺乏通过促进基因组不稳定性和抗肿瘤免疫来损害胰腺癌的进展。

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08 DOI: 10.1126/sciadv.adu8849

Neus Martínez-Bosch, Noemí Manero-Rupérez, Núria Vázquez-Bellón, Bennett Nickell-Hernández, Cristina Ventura-Blanch, Nura Lutfi, Carmen G Lechuga, Carlos Martínez, Mireia Moreno, Coral Ampurdanés, Etna Abad, Mar Iglesias, María Muñoz-Escribano, Ana Janic, Meritxell Rovira, Carmen Guerra, Gabriel A Rabinovich, José Yélamos, Pilar Navarro

{"title":"PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity.","authors":"Neus Martínez-Bosch, Noemí Manero-Rupérez, Núria Vázquez-Bellón, Bennett Nickell-Hernández, Cristina Ventura-Blanch, Nura Lutfi, Carmen G Lechuga, Carlos Martínez, Mireia Moreno, Coral Ampurdanés, Etna Abad, Mar Iglesias, María Muñoz-Escribano, Ana Janic, Meritxell Rovira, Carmen Guerra, Gabriel A Rabinovich, José Yélamos, Pilar Navarro","doi":"10.1126/sciadv.adu8849","DOIUrl":"https://doi.org/10.1126/sciadv.adu8849","url":null,"abstract":"Pancreatic cancer represents one of the most lethal tumors, characterized by an immunosuppressive microenvironment and a lack of cytotoxic immune cell infiltrates, which confer resistance to immunotherapy. Here, we demonstrate that deletion of poly(ADP-ribose) polymerase 2 (PARP2) in a Myc-driven mouse model of pancreatic cancer delays tumor progression and increases survival. Mechanistically, PARP2 loss induces enrichment of pathways associated with genomic instability and replicative stress, leading to increased γH2AX, chromosomal instability, and micronuclei accumulation. In addition to these tumor-intrinsic effects, PARP2 deletion reshapes the tumor microenvironment, promoting infiltration of cytotoxic T and natural killer cells while reducing immunosuppressive cell populations, enhancing antitumor cytotoxicity. These findings are recapitulated in a KrasG12D-driven orthotopic pancreatic ductal adenocarcinoma model. Collectively, our data support selective PARP2 inhibition as a promising therapeutic strategy for pancreatic cancer by impairing genome integrity and boosting antitumor immune response, thereby opening potential avenues for combating this devastating disease.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 19","pages":"eadu8849"},"PeriodicalIF":12.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein language models accurately predict polymorphic peptide-modulated NK cell receptor-HLA class I interaction strengths. 蛋白语言模型准确预测多态肽调节的NK细胞受体- hla I类相互作用强度。

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08 DOI: 10.1126/sciadv.aed3077

Abdallah AlShafey, Madeline Nelson, Mubasher Hassan, Andrzej Kloczkowski, William Ray, Salim I Khakoo, Jayajit Das

{"title":"Protein language models accurately predict polymorphic peptide-modulated NK cell receptor-HLA class I interaction strengths.","authors":"Abdallah AlShafey, Madeline Nelson, Mubasher Hassan, Andrzej Kloczkowski, William Ray, Salim I Khakoo, Jayajit Das","doi":"10.1126/sciadv.aed3077","DOIUrl":"https://doi.org/10.1126/sciadv.aed3077","url":null,"abstract":"Killer-cell immunoglobulin-like receptors (KIRs) are key determinants of natural killer cell function and are associated with the outcomes of infective, inflammatory, and neoplastic diseases. They form a polymorphic family of activating and inhibitory receptors that interact with polymorphic class I human leukocyte antigen (HLA-I) molecules. This interaction is dependent on the short peptides bound by the HLA-I molecules, including those derived from viruses and cancers. Identifying these peptides among the vast space of possible peptides based on the sequences of the interacting molecules can provide a valuable tool for developing personalized immunotherapy against infection and cancer. To address this challenge, we leveraged foundation protein language models and trained our model on available datasets for KIR-binding peptide-HLA complexes. Our tool generated excellent predictions with an area under receiver operator characteristic (AUROC) >0.8 for the majority of inhibitory KIRs and performed well (AUROC >0.7) for peptides generated during HIV and HCV infections. Our model holds substantial potential for advancing our understanding of immune regulation and the biophysical factors responsible for it, paving the way for KIR-specific therapeutic interventions.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 19","pages":"eaed3077"},"PeriodicalIF":12.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The anterior cingulate cortex modulates pupil-linked arousal. 前扣带皮层调节与瞳孔相关的觉醒。

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08 DOI: 10.1126/sciadv.adv5652

Nithik Chintalacheruvu, Anagha Kalelkar, Hector Alatriste-León, Joël Boutin, Vincent Breton-Provencher, Rafiq Huda

引用次数: 0

The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis. 胸膜实质纤维弹性增生图谱显示异常的细胞状态及其分区作为肺纤维化的替代路线图。

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08 DOI: 10.1126/sciadv.aeb5967

Jannik Ruwisch, Aurélie Cazes, Lena M Leiber, Raphaël Borie, Lavinia Neubert, Leonard Christian, Vincent Thomas de Montpréville, Adam Szmul, Farah Moussa, Stijn E Verleden, Svenja Gaedcke, Jan Hegermann, Jan Fuge, Matthias Ballmaier, Jan C Kamp, Mark Greer, Peter Braubach, Christopher Werlein, Fabius Ius, Theresa Graalmann, Kalil Aburahma, Laurens J De Sadeleer, Ryoko Egashira, Maximilian Ackermann, Daisuke Yamada, Marius M Hoeper, Christine Falk, Jens Gottlieb, Herbert B Schiller, Bart Vanaudenaerde, Benjamin Seeliger, Marie-Pierre Debray, Jean Francois Bernaudin, Lars Knudsen, Emmanuel Bergot, Joseph Jacob, Hervé Mal, Danny Jonigk, Sabine Dettmer, Pierre Mordant, Antje Prasse, Elie Fadel, Wim A Wuyts, Bruno Crestani, Naftali Kaminski, Aurélien Justet, Jonas C Schupp

{"title":"The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis.","authors":"Jannik Ruwisch, Aurélie Cazes, Lena M Leiber, Raphaël Borie, Lavinia Neubert, Leonard Christian, Vincent Thomas de Montpréville, Adam Szmul, Farah Moussa, Stijn E Verleden, Svenja Gaedcke, Jan Hegermann, Jan Fuge, Matthias Ballmaier, Jan C Kamp, Mark Greer, Peter Braubach, Christopher Werlein, Fabius Ius, Theresa Graalmann, Kalil Aburahma, Laurens J De Sadeleer, Ryoko Egashira, Maximilian Ackermann, Daisuke Yamada, Marius M Hoeper, Christine Falk, Jens Gottlieb, Herbert B Schiller, Bart Vanaudenaerde, Benjamin Seeliger, Marie-Pierre Debray, Jean Francois Bernaudin, Lars Knudsen, Emmanuel Bergot, Joseph Jacob, Hervé Mal, Danny Jonigk, Sabine Dettmer, Pierre Mordant, Antje Prasse, Elie Fadel, Wim A Wuyts, Bruno Crestani, Naftali Kaminski, Aurélien Justet, Jonas C Schupp","doi":"10.1126/sciadv.aeb5967","DOIUrl":"https://doi.org/10.1126/sciadv.aeb5967","url":null,"abstract":"Pleuroparenchymal fibroelastosis (PPFE) is a progressive interstitial lung disease (ILD) with defining histology of intra-alveolar fibrosis with septal elastosis (AFE), suggesting unique cellular disease processes. Here, we present a binational single-nucleus RNA sequencing atlas of PPFE, based on explanted lungs from 40 patients. Immunofluorescence microscopy, RNA in situ hybridization, micro-computed tomography (CT), and hierarchical phase-contrast (HiP) synchrotron CT provided spatial context. We identify PPFE-associated adventitial and elastofibrotic fibroblasts as key drivers of elastotic remodeling within an inflammatory microenvironment, maintained by immune cells forming tertiary lymphoid structures. Spatial mapping reveals an intriguing zonation of AFE, maintained by intercellular circuits between PPFE-associated cell types. Comparative analysis with idiopathic pulmonary fibrosis highlights CTHRC1+ fibrotic fibroblasts and aberrant basaloid cells as conserved profibrotic cellular machinery mediating collagen deposition across ILDs. This integrative atlas defines the cellular landscape of PPFE and dissects elastotic from fibrotic remodeling, providing a molecular rationale for niche-specific therapeutic strategies.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 19","pages":"eaeb5967"},"PeriodicalIF":12.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconfigurable second-harmonic generation via plasmonic nanoslits counteracting strain-induced suppression in monolayer MoS₂. 通过等离子体纳米狭缝抵消单晶硅中应变诱导抑制的可重构二次谐波产生。

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2026-05-08 DOI: 10.1126/sciadv.aed4575

Sobhagyam Sharma, Satyabrat Behera, Byung Hee Son, Gangseon Ji, Daehwan Park, Arunkumar Alagurasu, Mahsa Haddadi Moghaddam, Dai-Sik Kim, Seon Namgung, Yeong Hwan Ahn, Hyeong-Ryeol Park

{"title":"Reconfigurable second-harmonic generation via plasmonic nanoslits counteracting strain-induced suppression in monolayer MoS2.","authors":"Sobhagyam Sharma, Satyabrat Behera, Byung Hee Son, Gangseon Ji, Daehwan Park, Arunkumar Alagurasu, Mahsa Haddadi Moghaddam, Dai-Sik Kim, Seon Namgung, Yeong Hwan Ahn, Hyeong-Ryeol Park","doi":"10.1126/sciadv.aed4575","DOIUrl":"https://doi.org/10.1126/sciadv.aed4575","url":null,"abstract":"Second-harmonic generation (SHG) in monolayer transition-metal dichalcogenides is highly sensitive to mechanical strain, often leading to signal suppression under deformation. Here, we demonstrate reconfigurable SHG in monolayer MoS2 integrated with plasmonic nanoslits, where localized plasmonic fields counteract strain-induced suppression. The plasmonic nanoslits induce strong spatially localized field enhancement, yielding an SHG enhancement of up to 8000, estimated by normalizing the signal to the illumination area, relative to MoS2 on unpatterned Au films. Applying 1.2% compressive strain increases the SHG intensity by approximately threefold relative to the unstrained state, demonstrating effective strain-enabled modulation. Upon mechanical bending, the SHG response is reversibly modulated and remains stable after an initial preconditioning regime, retaining more than 95% of its initial intensity over repeated bending cycles. This strain-adaptive platform demonstrates robust cycling stability and provides a previously unexplored strategy for dynamically reconfigurable nonlinear metasurfaces, enabling applications in wearable sensors, tunable modulators, and compact frequency converters.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 19","pages":"eaed4575"},"PeriodicalIF":12.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0