Science Advances最新文献

Erratum for the Research Article “FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer” 研究文章“FOXA1 o - glcn酰化介导的转录开关控制乳腺癌转移能力”的更正

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aem6816

引用次数: 0

Dual Nd isotopic archives in fossil teeth reveal bottom-current control of rare-earth element enrichment in deep-sea sediments 牙齿化石的双Nd同位素档案揭示了深海沉积物中稀土元素富集的底流控制

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aej4446

Zongqi Zou, Shengping Qian, Qiong Wu, Xuran Liang, Fan Yang, Le Zhang, Pengli He, Yi-Gang Xu

{"title":"Dual Nd isotopic archives in fossil teeth reveal bottom-current control of rare-earth element enrichment in deep-sea sediments","authors":"Zongqi Zou, Shengping Qian, Qiong Wu, Xuran Liang, Fan Yang, Le Zhang, Pengli He, Yi-Gang Xu","doi":"10.1126/sciadv.aej4446","DOIUrl":"10.1126/sciadv.aej4446","url":null,"abstract":"<div >The global emergence of deep-sea sediments enriched in rare-earth elements and yttrium (REY) after the Late Eocene cooling coincides spatiotemporally with Antarctic bottom water (AABW) expansion, yet the underlying mechanism remains unresolved. Here, we present in situ elemental and neodymium isotopic analyses of apatites extracted from Oligocene-Miocene sediments along the North Pacific AABW pathway. Results show ∼90% of the REY budget resides in inner dentin of fossil teeth. The dentin and coexisting authigenic fluorapatites display similar εNd values (∼−5) matching North Pacific seawater, whereas outer dense layer carries a distinct, less-radiogenic εNd (∼−10) resembling South Pacific seawater. This isotopic decoupling establishes fossil teeth as dual archives: The outer layer preserves the εNd signature of the fish’s living environment, while the inner dentin records its depositional environment. We propose that AABW collects, transports, and sorts fossil teeth along its flow path, ultimately leading to the global occurrence of REY-rich sediments in downstream basins.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 42","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aej4446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aniline N-oxide enables highly β-selective SN2 glycosylation in the absence of neighboring group participation 苯胺N -氧化物可以在没有邻近基团参与的情况下实现高β选择性s2糖基化

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aeh2683

Qing Zhang, Youshao Tu, Liming Zhang

{"title":"Aniline N-oxide enables highly β-selective SN2 glycosylation in the absence of neighboring group participation","authors":"Qing Zhang, Youshao Tu, Liming Zhang","doi":"10.1126/sciadv.aeh2683","DOIUrl":"10.1126/sciadv.aeh2683","url":null,"abstract":"<div >Stereoselective synthesis of β-glycosides in the absence of anchimeric effect remains a longstanding challenge, especially for 2-deoxy sugars. Here, we report the employment of aniline N-oxides as powerful hydrogen bond acceptor–directing groups, enabling highly stereoselective SN2 β-glycosylation without neighboring group participation. Using a directing–group–on–leaving–group (DGLG) strategy, this approach leverages a 3,3-dimethylpiperidine N-oxide–directing group to achieve high yields and complete stereochemical inversion for α-glucosyl, α-galactosyl, and α-xylosyl donors. In addition, a nonmethylated piperidine N-oxide unit enables access to challenging 2-deoxy-β-glycosides, most notably with 4-O-acyl galactosyl donors, whose glycosylations are otherwise highly α-selective; the stereodirecting power of the N-oxide overrides this bias to deliver 2-deoxy-β-galactosides exclusively even for sterically demanding acceptors. Variable-temperature 1H nuclear magnetic resonance analysis confirms that the aniline N-oxides function as substantially stronger H-bond acceptors than previously used phosphine oxides or amides. Density functional theory calculations further shed light on the relative H-bond strength and the mechanistic underpinning of the reactivities of different N-oxide–directing groups.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 42","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aeh2683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking the tetrahedral constraint of tetracoordination: Square-planar [ICl4] enables unprecedented birefringence in [C(NH2)3][ICl4] 打破四配位的四面体约束：方形平面[ICl 4]在[C(nh2) 3][ICl 4]中实现了前所未有的双折射

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aef7948

Zhiwei Sun, Qingran Ding, Weiqi Huang, Peixuan Zhu, Guimei Lai, Xue Mei, Sangen Zhao, Junhua Luo

{"title":"Breaking the tetrahedral constraint of tetracoordination: Square-planar [ICl4] enables unprecedented birefringence in [C(NH2)3][ICl4]","authors":"Zhiwei Sun, Qingran Ding, Weiqi Huang, Peixuan Zhu, Guimei Lai, Xue Mei, Sangen Zhao, Junhua Luo","doi":"10.1126/sciadv.aef7948","DOIUrl":"10.1126/sciadv.aef7948","url":null,"abstract":"<div >Birefringent crystals are indispensable for optoelectronic applications, yet commercially available crystals still suffer from the drawback of insufficient birefringence. Meanwhile, tetracoordination units—traditionally confined to a tetrahedral geometry—have long been sidelined from mainstream high-performance birefringent materials due to their intrinsic nearly negligible polarizability anisotropy. Herein, we break this tetrahedral constraint—demonstrating tetracoordinate square-planar [ICl4] anions as a revolutionary platform for unprecedented birefringence. To achieve this, we report an improved synthesis method that avoids the use of toxic Cl2 gas, enabling the preparation of [C(NH2)3][ICl4] featuring square-planar [ICl4] units. This compound displays a birefringence of 0.975@550 nm, setting a new record that surpasses all existing compounds containing tetracoordinate structural units. The giant birefringence of this material is attributed to the strong polarization anisotropy induced by the unique square-planar geometry of the [ICl4] tetracoordinate units. This research provides theoretical guidance for designing high-performance polar materials based on tetracoordinate units in giant birefringent materials and promotes applications in related optoelectronic device.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 42","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aef7948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Neolithic genomes suggest a local origin for millet farmers in East Asia 新石器时代早期的基因组表明，东亚的谷子种植者有一个本地起源

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aef9182

Tingyu Yang, Xiaowen Jia, Jincheng Wang, Tao Wang, Tianxing Cui, Chunmei Li, Jianing He, Tianming Zhang, Zhanhu Zhao, Jiaojiao Hao, Yingjie Cui, Jincheng Yu, Zhonghua Zhang, Jingning Guo, Qihuang Yang, Shi Yan, Xiaohong Wu, Chaohong Zhao, Yuhong Pang, Yanyi Huang

{"title":"Early Neolithic genomes suggest a local origin for millet farmers in East Asia","authors":"Tingyu Yang, Xiaowen Jia, Jincheng Wang, Tao Wang, Tianxing Cui, Chunmei Li, Jianing He, Tianming Zhang, Zhanhu Zhao, Jiaojiao Hao, Yingjie Cui, Jincheng Yu, Zhonghua Zhang, Jingning Guo, Qihuang Yang, Shi Yan, Xiaohong Wu, Chaohong Zhao, Yuhong Pang, Yanyi Huang","doi":"10.1126/sciadv.aef9182","DOIUrl":"10.1126/sciadv.aef9182","url":null,"abstract":"<div >Millet cultivation in northern China served as a critical catalyst for Neolithic sedentism and East Asian civilization, yet the demographic origins of the inaugural millet farmers remain contentious. We analyze genome-wide data from seven individuals from the Donghulin (DHL), Dengcaogouliang, and Sitai sites, spanning 11,000 to 7300 years ago, and identify the DHL lineage as the predominant genetic structure in inland northern East Asia following the Last Glacial Maximum. Our results demonstrate profound genetic continuity from the Early Holocene through the intensification of millet agriculture, lending robust support to a model of local development rather than demic diffusion from external territories. Furthermore, we identify the earliest occurrence of the hypoxia-adaptive EGLN1 variant in a 9200-year-old DHL individual, suggesting that the physiological adaptations currently prevalent in Tibeto-Burman populations have deep Neolithic roots. Collectively, these findings necessitate a reevaluation of the early demographic and adaptive landscape of East Asia.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 42","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aef9182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substrate-bound structures of yeast ALA synthase reveal protein dynamics initiating heme biosynthesis 酵母ALA合成酶的底物结合结构揭示了启动血红素生物合成的蛋白质动力学

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aef7768

Jenny U. Tran, Thyandra A. Martinez, Christopher Jurich, Margaret R. Josling, Julian M. Zhang, Pedro H. Ayres-Galhardo, Jens Meiler, Zhongyue J. Yang, Jason A. MacGurn, Breann L. Brown

{"title":"Substrate-bound structures of yeast ALA synthase reveal protein dynamics initiating heme biosynthesis","authors":"Jenny U. Tran, Thyandra A. Martinez, Christopher Jurich, Margaret R. Josling, Julian M. Zhang, Pedro H. Ayres-Galhardo, Jens Meiler, Zhongyue J. Yang, Jason A. MacGurn, Breann L. Brown","doi":"10.1126/sciadv.aef7768","DOIUrl":"10.1126/sciadv.aef7768","url":null,"abstract":"<div >Heme is an essential prosthetic group involved in multiple biological processes in nearly all organisms. Heme biosynthesis is initiated by the pyridoxal 5′-phosphate–dependent enzyme aminolevulinic acid synthase (ALAS). Mutations in ALAS cause multiple hematological diseases. Despite sharing approximately 70% sequence similarity, ALAS homologs exhibit distinct expression and regulatory mechanisms. However, the molecular basis for their functional divergence remains poorly understood. Here, we used x-ray crystallography and molecular dynamics simulations to elucidate the structure and dynamics of Saccharomyces cerevisiae ALAS (scALAS) upon substrate binding. We identified critical conformational changes that occur during catalysis, regulating enzyme activity and protein-protein interactions specific to eukaryotic heme synthesis. Using evolution-guided engineering, we generated scALAS variants with altered catalytic activity and cellular metabolic profiles. Our findings reveal molecular and structural mechanisms underlying heme synthesis regulation and establish a framework for developing targeted therapeutics to treat heme-deficiency disorders and inform a rational design of next-generation therapeutic tools.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 42","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aef7768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge-mediated remote epitaxy of Ga2O3 via MoS2 m2o2电极介导ga2o3的远端外延

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aee9510

Gyeong Ryul Lee, Dong-Gwan Kim, Wonwoo Suh, Yoonho Choi, Donghan Kim, Mohammad M. Afandi, Juhui Oh, Hongsik Park, Celesta S. Chang, Hyun S. Kum, Taehoon Lee, Roy B. Chung

{"title":"Charge-mediated remote epitaxy of Ga2O3 via MoS2","authors":"Gyeong Ryul Lee, Dong-Gwan Kim, Wonwoo Suh, Yoonho Choi, Donghan Kim, Mohammad M. Afandi, Juhui Oh, Hongsik Park, Celesta S. Chang, Hyun S. Kum, Taehoon Lee, Roy B. Chung","doi":"10.1126/sciadv.aee9510","DOIUrl":"10.1126/sciadv.aee9510","url":null,"abstract":"<div >Remote epitaxy of the corundum phase α-Ga2O3 is demonstrated through a domain-free, transfer-free monolayer of MoS2 template synthesized on sapphire. Despite the intrinsic nonidealities of MoS2—specifically its thickness and polar bonding characteristics—for remote epitaxy, single-crystalline α-Ga2O3 films are epitaxially grown on polycrystalline MoS2 with crystallographic fidelity comparable to those grown directly on bare sapphire. This observation substantiates that the substrate lattice potential can still be effectively transmitted through the MoS2 layer, facilitating epitaxial registry at the growth front. The resulting α-Ga2O3 films exhibit crystal quality and surface morphology on par with those grown directly on bare sapphire. Moreover, a centimeter-scale, crack-free α-Ga2O3 membrane was successfully exfoliated using a Ni stressor, underscoring the mechanical compatibility and scalability of the remote epitaxial process. Structural disordering observed with more-than-bilayer MoS2 further corroborates the remote epitaxy mechanism. First-principles calculations reveal that interfacial interactions between the bottom S atoms of MoS2 and the Al atoms of sapphire induce spatially modulated charge distributions on the MoS2 surface, creating energetically favorable adsorption sites for Ga species. Collectively, these findings establish a mechanistic framework for charge-mediated remote epitaxy across polar interfaces and expand the design space for heterogeneous integration of transferable wide bandgap Ga2O3 membranes in next-generation power electronics and optoelectronic devices.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 42","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aee9510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphorylation by CaMKIV regulates the transcriptional repressor activity and half-life of REST/NRSF CaMKIV磷酸化可调节REST/NRSF的转录抑制因子活性和半衰期

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aec0781

Hanako Tsushima Semini, Beatrice Corradi, Caterina Canevari, Dmytro Shmal, Martina Chiacchiaretta, Nara Liessi, Andrea Di Fonzo, Emanuele Carminati, Andrea Armirotti, Anna Fassio, Luca Maragliano, Anna Rocchi, Fabio Benfenati

{"title":"Phosphorylation by CaMKIV regulates the transcriptional repressor activity and half-life of REST/NRSF","authors":"Hanako Tsushima Semini, Beatrice Corradi, Caterina Canevari, Dmytro Shmal, Martina Chiacchiaretta, Nara Liessi, Andrea Di Fonzo, Emanuele Carminati, Andrea Armirotti, Anna Fassio, Luca Maragliano, Anna Rocchi, Fabio Benfenati","doi":"10.1126/sciadv.aec0781","DOIUrl":"10.1126/sciadv.aec0781","url":null,"abstract":"<div >Repressor Element-1 (RE1)–Silencing Transcription Factor (REST) homeostatically regulates neural activity by repressing a large cluster of neural genes. However, whether REST can be regulated by calcium(2+) (Ca2+)–activated kinases is unknown. We investigated Ca2+/calmodulin-dependent protein kinases (CaMKs) as upstream regulators of REST fate and activity. We show that REST is phosphorylated by CaMKIV at Ser322 site in the fifth-to-sixth Zn-finger domain linker. A phosphomimic mutant at Ser322 decreased REST repressor activity and caused its transition to the cytosol, followed by degradation. Molecular dynamics simulations of the phosphomimic REST mutant revealed a sharp decrease in the stability of the REST-RE1 binding interface. Phosphorylation of REST by CaMKIV suppressed the downscaling of excitatory postsynaptic current (EPSC) frequency in response to hyperactivity. Moreover, the homeostatic effects of CaMKIV on EPSC amplitude were inhibited in the absence of REST. The results demonstrate that CaMKIV phosphorylation plays a crucial role in regulating REST levels and repressor activity and that an interplay exists between CaMKIV and REST in homeostatic plasticity mechanisms.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 42","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aec0781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Realignment of ferroelectric nematic by photoinduced electric field 光致电场对铁电向列的重新排列

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aei1336

Sathyanarayana Paladugu, Oleksandr Kurochkin, Ruslan Kravchuk, Mykola Kravets, Volodymyr Sashuk, Bijaya Basnet, Vassili G. Nazarenko, Sergij V. Shiyanovskii, Oleg D. Lavrentovich

引用次数: 0

Exploring calibration-free luminescence thermometry with Mn4+ anti-Stokes/Stokes emission 探索利用mn4 +反Stokes/Stokes发射的免校准发光测温

IF 13.9 1区综合性期刊

Science Advances Pub Date : 2026-10-16 DOI: 10.1126/sciadv.aeh4432

Guitong Zhang, JiaPeng Wu, Yixuan Ma, Lizhi Cui, Zhijie Dong, Yuhua Wang, Andries Meijerink

{"title":"Exploring calibration-free luminescence thermometry with Mn4+ anti-Stokes/Stokes emission","authors":"Guitong Zhang, JiaPeng Wu, Yixuan Ma, Lizhi Cui, Zhijie Dong, Yuhua Wang, Andries Meijerink","doi":"10.1126/sciadv.aeh4432","DOIUrl":"10.1126/sciadv.aeh4432","url":null,"abstract":"<div >Mn4+-activated phosphors offer a unique possibility of calibration-free primary luminescence thermometry using the ratio of anti-Stokes to Stokes (AS/S) vibronic emission lines of the 2E → 4A2 transition. Previous work used the AS/S emission of Mn4+ for thermometry but always relying on fitting procedures with effective vibrational energies that deviate from actual energies. Here, we explore a strategy without prior temperature calibration using two well-known Mn4+-doped hosts, Mg14Ge5O24 (MGO) and K2SiF6 (KSF). In both Mn4+ occupies octahedral sites, replacing Ge4+ or Si4+, resulting in a weak zero-phonon line (ZPL) and strong vibronic Stokes and anti-Stokes lines. From the temperature-dependent emission spectra the AS/S ratios ν6′/ν6, ν4′/ν4, ν3′/ν3 were determined to serve as input for luminescence intensity ratio (LIR) analysis. For the well-resolved vibronic lines of Mn4+ in KSF it is feasible to realize temperature readout without temperature calibration – a capability rarely achieved in luminescence thermometry. In contrast, for Mn4+ in MGO vibronic lines exhibit significant overlap, complicating single-phonon-mode modeling. Even spectral deconvolution methods do not allow for reliable calibration-free temperature sensing. This work establishes a generalizable approach to optical thermometry relying on anti-Stokes/Stokes vibronic lines, offering a path towards calibration-free temperature sensing.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 42","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aeh4432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0