Science Advances最新文献

HIV-1 manipulates CD96 on CD4+ T cells to subvert antiviral immunity HIV-1操纵CD4+ T细胞上的CD96来破坏抗病毒免疫

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adx7485

Sandra Dehn, Rabea Burkhard, Johanna Leyens, Tabea Kaiser, Simone Brandimarte, Dinah Heiligensetzer, Herwig Koppensteiner, Baubak Bajoghli, Stephan Hailfinger, Karin Schilbach, Michael Schindler

{"title":"HIV-1 manipulates CD96 on CD4+ T cells to subvert antiviral immunity","authors":"Sandra Dehn, Rabea Burkhard, Johanna Leyens, Tabea Kaiser, Simone Brandimarte, Dinah Heiligensetzer, Herwig Koppensteiner, Baubak Bajoghli, Stephan Hailfinger, Karin Schilbach, Michael Schindler","doi":"10.1126/sciadv.adx7485","DOIUrl":"10.1126/sciadv.adx7485","url":null,"abstract":"<div >HIV-1 evades immune responses by modulating plasma membrane receptors. Using a flow cytometry–based screening, we profiled 332 surface receptors on HIV-1–infected primary CD4<sup>+</sup> T cells and identified 23 down-regulated receptors, including known targets such as CD4, MHCI, CCR7, and CD62L. CD96, an inhibitory natural killer (NK) cell receptor poorly studied in human CD4<sup>+</sup> T cells, was markedly down-regulated. This modulation, mediated by the viral proteins Nef and Vpu, surpassed that of other NK-associated receptors such as CD155 and NTB-A and is conserved across lentiviruses. CD96<sup>Hi</sup> CD4<sup>+</sup> T cells exhibited a proinflammatory T<sub>H</sub>1/T<sub>H</sub>17 phenotype characterized by IFN-γ and IL-17 secretion and displayed impaired migration in vivo. Furthermore, CD96 ligation enhanced IFN-γ release upon viral peptide stimulation and promoted the secretion of T<sub>H</sub>1/T<sub>H</sub>17-associated cytokines. Our findings suggest that CD96 regulates antiviral immune responses and maintains proinflammatory properties in CD4<sup>+</sup> T cells. Thus, its down-regulation represents a previously unknown HIV-1 immune evasion strategy, with implications for exploiting CD96 as immunotherapeutic target.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx7485","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive superposition compound eyes for perceptions under distinct light levels 适应叠加复眼在不同光照水平下的感知

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.ady2069

Heng Jiang, Chi Chung Tsoi, Yao Chai, Weixing Yu, Chi-Hung Tang, Yu Du, Zuankai Wang, Huaping Jia, Xuming Zhang

{"title":"Adaptive superposition compound eyes for perceptions under distinct light levels","authors":"Heng Jiang, Chi Chung Tsoi, Yao Chai, Weixing Yu, Chi-Hung Tang, Yu Du, Zuankai Wang, Huaping Jia, Xuming Zhang","doi":"10.1126/sciadv.ady2069","DOIUrl":"10.1126/sciadv.ady2069","url":null,"abstract":"<div >Optical superposition natural compound eyes (OSNCEs) allow circadian insects to thrive in varying light conditions thanks to their unique anatomical structures. This provides a blueprint for optical superposition artificial compound eyes (OSACEs) that can adapt to different illumination intensities. However, OSACEs have received limited research attention until recently, with most studies focusing on apposition compound eyes that operate only in bright light. In this work, we accurately replicate the anatomical features and the ganglia adjustments of OSNCEs using lensed plastic optical fibers as artificial ommatidia. As the core part of this work, we implement a spatial approach alongside a temporal approach derived from both hardware and algorithms to accommodate lighting variations of up to 1000 times while still maintaining high image quality such as 180° field of view, minimal distortion, nearly infinite depth of field, and ultrafast motion detection. These adaptive biomimetic features make the OSACE very promising for surveillance, virtual reality, and unmanned aerial vehicles.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady2069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient energy transfer in a hybrid organic-inorganic van der Waals heterostructure 有机-无机杂化范德华异质结构的有效能量传递

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adw3969

Xiaoqing Chen, Huijuan Zhao, Ruixiang Fei, Chun Huang, Jingsi Qiao, Cheng Sun, Haiming Zhu, Li Zhan, Zehua Hu, Songlin Li, Li Yang, Zemin Tang, Lianhui Wang, Yi Shi, Wei Ji, Jian-Bin Xu, Li Gao, Xuetao Gan, Xinran Wang

{"title":"Efficient energy transfer in a hybrid organic-inorganic van der Waals heterostructure","authors":"Xiaoqing Chen, Huijuan Zhao, Ruixiang Fei, Chun Huang, Jingsi Qiao, Cheng Sun, Haiming Zhu, Li Zhan, Zehua Hu, Songlin Li, Li Yang, Zemin Tang, Lianhui Wang, Yi Shi, Wei Ji, Jian-Bin Xu, Li Gao, Xuetao Gan, Xinran Wang","doi":"10.1126/sciadv.adw3969","DOIUrl":"10.1126/sciadv.adw3969","url":null,"abstract":"<div >Two-dimensional (2D) materials offer strong light-matter interaction and design flexibility beyond bulk semiconductors, but an intrinsic limit is the low absorption imposed by the atomic thickness. A long-sought-after goal is to achieve complementary absorption enhancement through energy transfer (ET) to break this limit. However, it is found challenging due to the competing charge transfer (CT) process and lack of resonance in exciton states. Here, we report highly efficient ET in a 2D hybrid organic-inorganic heterostructure (HOIST) of Me-PTCDI/WS<sub>2</sub>. Resonant ET is observed leading to enhanced WS<sub>2</sub> photoluminescence (PL) by 124 times. We identify Dexter exchange between the Frenkel state in donor and an excited 2<i>s</i> state in acceptor as the main ET mechanism, as supported by density functional theory calculations. We further demonstrate ET-enhanced phototransistor devices with enhanced responsivity by nearly 1000 times without sacrificing the response time. Our results expand the understanding of interlayer relaxation processes in 2D materials and open opportunities in optoelectronic devices.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw3969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging port state measures to combat illegal, unreported, and unregulated fishing 利用港口国措施打击非法、未报告和无管制捕鱼

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.ads1592

Elizabeth R. Selig, Colette C. C. Wabnitz, Shinnosuke Nakayama, Jaeyoon Park, Richard Barnes, Robert Blasiak, Dawn Borg-Costanzi, Bronwen Golder, Jean-Baptiste Jouffray, Jim Leape, Jessica L. Decker Sparks

{"title":"Leveraging port state measures to combat illegal, unreported, and unregulated fishing","authors":"Elizabeth R. Selig, Colette C. C. Wabnitz, Shinnosuke Nakayama, Jaeyoon Park, Richard Barnes, Robert Blasiak, Dawn Borg-Costanzi, Bronwen Golder, Jean-Baptiste Jouffray, Jim Leape, Jessica L. Decker Sparks","doi":"10.1126/sciadv.ads1592","DOIUrl":"10.1126/sciadv.ads1592","url":null,"abstract":"<div >Illegal, unreported, and unregulated (IUU) fishing threatens the sustainability of fisheries and communities dependent on them. The Port State Measures Agreement (PSMA) is a key tool for combatting IUU fishing by foreign fleets, requiring standardized inspections, information sharing, and port denial. Using satellite data, we characterized how PSMA has affected high seas vessel behavior and identify opportunities to strengthen its impact. PSMA adoption has increased travel distances to the nearest ports in States not Party to PSMA and channeled more fishing effort to domestic and PSMA Party ports. However, domestic fishing fleets need greater attention because they constituted 66% of port visits in 2021. Among reflagged vessels, we also found a 30% increase in visits to PSMA ports by vessels shifting to domestic flags after PSMA entered into force, allowing them to avoid PSMA requirements for foreign vessels. Our results highlight the centrality of implementing consistent, effective port State measures across foreign and domestic fleets to address IUU fishing risks.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads1592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning– and multilayer molecular network–assisted screening hunts fentanyl compounds 机器学习和多层分子网络辅助筛选芬太尼化合物

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adw2799

Changzhi Shi, Wanli Li, Yang Wang, Xi Chen, Meixiang Yu, Hai Zhang, Zecang You, Maoyong Song, Xiaojun Deng, Mingliang Fang

{"title":"Machine learning– and multilayer molecular network–assisted screening hunts fentanyl compounds","authors":"Changzhi Shi, Wanli Li, Yang Wang, Xi Chen, Meixiang Yu, Hai Zhang, Zecang You, Maoyong Song, Xiaojun Deng, Mingliang Fang","doi":"10.1126/sciadv.adw2799","DOIUrl":"10.1126/sciadv.adw2799","url":null,"abstract":"<div >Fentanyl and its analogs are a global concern, making their accurate identification essential for public health. Here, we introduce Fentanyl-Hunter, a screening platform that uses a machine learning classifier and multilayer molecular network to select and annotate fentanyl compounds using mass spectrometry (MS). Our classification model, based on 772 fentanyl spectra and spectral binning feature engineering, achieved an <i>F</i><sub>1</sub> score of 0.868 ± 0.02. The multilayer network, based on spectral similarity and paired mass distances, covers more than 87% of known fentanyls. Fentanyl-Hunter identified fentanyl members in biological and environmental samples. During biotransformation, 35 metabolites from four widely consumed fentanyl derivatives were identified. Norfentanyl was the major fentanyl compound in wastewater. Retrospective screening of these biomarkers across more than 605,000 MS files in public datasets revealed fentanyl, sufentanil, norfentanyl, or remifentanil acid in more than 250 samples from eight major countries, indicating the potential widespread presence of fentanyl.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw2799","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robotic micromanipulation for patterned and complex organoid biofabrication 机器人显微操作模式和复杂的类器官生物制造

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adz0808

Mingsi Tong, Gang Huang, Songlin Zhuang, Xinghu Yu, Delin Hu, Weiyang Lin, Yang Wu, Yuchen Chen, Shijia Cheng, Meng Jiang, Li Zhang, Huijun Gao

{"title":"Robotic micromanipulation for patterned and complex organoid biofabrication","authors":"Mingsi Tong, Gang Huang, Songlin Zhuang, Xinghu Yu, Delin Hu, Weiyang Lin, Yang Wu, Yuchen Chen, Shijia Cheng, Meng Jiang, Li Zhang, Huijun Gao","doi":"10.1126/sciadv.adz0808","DOIUrl":"10.1126/sciadv.adz0808","url":null,"abstract":"<div >Organoids have emerged as powerful models for recapitulating tissue physiology and pathology in biomedical research. However, the need for consistent and complex manufacturing of organoids remains a challenge. The absence of standardization and quality control of cells dispersed within extracellular matrices impedes the widespread application of organoids. Here, we introduce a micromanipulation platform that effectively constrains cell distribution to enable patterned and complex organoid biofabrication. This system integrates multidimensional cell sense technology to provide real-time feedback, enabling adaptive fluid dynamics control that robustly compensates for seeding-induced nonlinear fluidic perturbations. Through this closed-loop control, the micromanipulation platform effectively restrains the spatial distribution of multiple cell types, promoting consistent self-assembly. Using this platform, we have successfully achieved programmable organoid manufacturing as well as the construction of assembloids composed of multiple cell types that better mimic mature organ microenvironments. This supports advancements in organoid-based biomechanism discovery, drug screening, and other organoid-related investigations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz0808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Planetary Health Diet and risk of mortality and chronic diseases: Results from US NHANES, UK Biobank, and a meta-analysis 行星健康饮食与死亡和慢性病风险：来自美国NHANES、英国生物银行和荟萃分析的结果

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adq5147

Yuanyuan Wang, Da Pan, Chen Zhang, Dengfeng Xu, Yifei Lu, Shiyu Yin, Pei Wang, Jiayue Xia, Junhui Yu, Lirong Dong, Guiju Sun

引用次数: 0

Repurposing polyethylene terephthalate plastic waste to capture carbon dioxide 重新利用聚对苯二甲酸乙二醇酯塑料废物来捕获二氧化碳

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adv5906

Margarita Poderyte, Rodrigo Lima, Peter Illum Golbækdal, Dennis Wilkens Juhl, Kathrine L. Olesen, Niels Chr. Nielsen, Arianna Lanza, Ji-Woong Lee

{"title":"Repurposing polyethylene terephthalate plastic waste to capture carbon dioxide","authors":"Margarita Poderyte, Rodrigo Lima, Peter Illum Golbækdal, Dennis Wilkens Juhl, Kathrine L. Olesen, Niels Chr. Nielsen, Arianna Lanza, Ji-Woong Lee","doi":"10.1126/sciadv.adv5906","DOIUrl":"10.1126/sciadv.adv5906","url":null,"abstract":"<div >Polyethylene terephthalate (PET) is a ubiquitous polymer with a lack of viable waste management solutions besides mechanical recycling, incineration, and landfilling. Herein, we demonstrate a chemical upcycling of PET waste into materials for CO<sub>2</sub> capture via aminolysis. The aminolysis reaction products—a bis-aminoamide (BAETA) and oligomers—exhibit high CO<sub>2</sub> capture capacity up to 3.4 moles per kilogram as a stand-alone organic solid material. BAETA shows strong chemisorption featuring high selectivity for CO<sub>2</sub> capture from flue gas (5 to 20% CO<sub>2</sub>) and ambient air (~400 parts per million CO<sub>2</sub>) under humid conditions. Our thermally stable material (>250°C) enables CO<sub>2</sub> capture at high temperatures (up to 170°C) for multiple cycles. Scalability of the material production was demonstrated by performing aminolysis of untreated consumer waste PET of 1 kilogram. Our approach introduces a simple and straightforward solution that can address both plastic waste and carbon dioxide, offering a potential pathway toward net negative emissions.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv5906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of ketonyl C-glycosides from designed glycosyl sulfides and styrenes by a radical pathway 设计的糖基硫化物和苯乙烯自由基法制备酮基c -糖苷

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.ady2175

Weidong Shang, Yanan Hu, Yang He, Dawen Niu, Weimin Li

{"title":"Preparation of ketonyl C-glycosides from designed glycosyl sulfides and styrenes by a radical pathway","authors":"Weidong Shang, Yanan Hu, Yang He, Dawen Niu, Weimin Li","doi":"10.1126/sciadv.ady2175","DOIUrl":"10.1126/sciadv.ady2175","url":null,"abstract":"<div >Ketonyl <i>C</i>-glycosides, a vital subclass of alkyl <i>C</i>-glycosides, play essential roles in drug discovery, biochemistry, and materials sciences. However, a practical strategy that merges bench-stable glycosyl donors with styrenes—a ubiquitous class of synthetic building blocks—remains elusive. Herein, we report a simple and general approach for synthesizing ketonyl <i>C</i>-glycosides. The transformation uses designed glycosyl sulfides as air- and moisture-stable precursors to glycosyl radicals, styrenes as aglycone sources, and dimethyl sulfoxide as both an oxidant and solvent, proceeding under photoredox catalysis. Glycosyl radicals are generated from glycosyl sulfides via efficient unimolecular homolytic substitution. This approach obviates harsh conditions for donor activation and the use of activated aglycone precursors, accommodating extensive functional groups and heterocycles. The reaction also exhibits high stereoselectivity across various glycosyl units. Demonstrating synthetic versatility, this method enables efficient access to diverse drug-sugar conjugates and complex <i>C</i>-glycopeptidomimetics. Mechanistic studies reveal key intermediates, suggesting a radical-polar crossover pathway. This study offers a broadly applicable approach to valuable sugar-containing structures.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady2175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational design of potent and selective binders of BAK and BAX BAK和BAX强效和选择性结合剂的计算设计

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adt4170

Stephanie Berger, Erinna F. Lee, Tiffany J. Harris, Sharon Tran, Asim K. Bera, Lauren Arguinchona, Alex Kang, Banumathi Sankaran, Sila Kasapgil, Michelle S. Miller, Sean Smyth, Mariam Lutfi, Rachel T. Uren, Ruth M. Kluck, Peter M. Colman, Walter D. Fairlie, Peter E. Czabotar, David Baker, Richard W. Birkinshaw

{"title":"Computational design of potent and selective binders of BAK and BAX","authors":"Stephanie Berger, Erinna F. Lee, Tiffany J. Harris, Sharon Tran, Asim K. Bera, Lauren Arguinchona, Alex Kang, Banumathi Sankaran, Sila Kasapgil, Michelle S. Miller, Sean Smyth, Mariam Lutfi, Rachel T. Uren, Ruth M. Kluck, Peter M. Colman, Walter D. Fairlie, Peter E. Czabotar, David Baker, Richard W. Birkinshaw","doi":"10.1126/sciadv.adt4170","DOIUrl":"10.1126/sciadv.adt4170","url":null,"abstract":"<div >Potent and selective binders of the key proapoptotic proteins BAK and BAX have not been described. We use computational protein design to generate high affinity binders of BAK and BAX with greater than 100-fold specificity for their target. Both binders activate their targets when at low concentration, driving pore formation, but inhibit membrane permeabilization when in excess. Crystallography shows that the BAK binder induces BAK unfolding, exposing the α6 helix and BH3 domain. Together, these data suggest that upon binding, BAK or BAX unfold; at high binder concentrations, self-association of the partially folded BAK or BAX proteins is blocked and the membrane remains intact, whereas at low concentrations, dimers form, and the membrane ruptures. Our designed binders modulate apoptosis via direct, specific interactions with BAK and BAX and reveal that for therapeutic strategies targeting BAK and BAX, inhibition requires saturating binder concentrations at the site of action.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt4170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0