Science Advances最新文献

Aging activates escape of the silent X chromosome in the female mouse hippocampus.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.ads8169

Margaret Gadek, Cayce K Shaw, Samira Abdulai-Saiku, Rowan Saloner, Francesca Marino, Dan Wang, Luke W Bonham, Jennifer S Yokoyama, Barbara Panning, Bérénice A Benayoun, Kaitlin B Casaletto, Vijay Ramani, Dena B Dubal

{"title":"Aging activates escape of the silent X chromosome in the female mouse hippocampus.","authors":"Margaret Gadek, Cayce K Shaw, Samira Abdulai-Saiku, Rowan Saloner, Francesca Marino, Dan Wang, Luke W Bonham, Jennifer S Yokoyama, Barbara Panning, Bérénice A Benayoun, Kaitlin B Casaletto, Vijay Ramani, Dena B Dubal","doi":"10.1126/sciadv.ads8169","DOIUrl":"10.1126/sciadv.ads8169","url":null,"abstract":"Women live longer than men and exhibit less cognitive aging. The X chromosome contributes to sex differences, as females harbor an inactive X (Xi) and active X (Xa), in contrast to males with only an Xa. Thus, reactivation of silent Xi genes may contribute to sex differences. We use allele-specific, single-nucleus RNA sequencing to show that aging remodels transcription of the Xi and Xa across hippocampal cell types. Aging preferentially changed gene expression on the X's relative to autosomes. Select genes on the Xi underwent activation, with new escape across cells including in the dentate gyrus, critical to learning and memory. Expression of the Xi escapee Plp1, a myelin component, was increased in the aging hippocampus of female mice and parahippocampus of women. AAV-mediated Plp1 elevation in the dentate gyrus of aging male and female mice improved cognition. Understanding how the Xi may confer female advantage could lead to novel targets that counter brain aging and disease in both sexes.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eads8169"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between hormone therapy use and tau accumulation in brain regions vulnerable to Alzheimer's disease.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.adt1288

Gillian T Coughlan, Zoe Rubinstein, Hannah Klinger, Kelly A Lopez, Stephaine Hsieh, Rory Boyle, Mabel Seto, Diana Townsend, Danielle Mayblyum, Emma Thibault, Heidi I L Jacobs, Michelle Farrell, Jennifer S Rabin, Kate Papp, Rebecca Amariglio, Suzanne Baker, Cristina Lois, Dorene Rentz, Julie Price, Aaron Schultz, Michael Properzi, Keith Johnson, Reisa Sperling, Rachel F Buckley

{"title":"Associations between hormone therapy use and tau accumulation in brain regions vulnerable to Alzheimer's disease.","authors":"Gillian T Coughlan, Zoe Rubinstein, Hannah Klinger, Kelly A Lopez, Stephaine Hsieh, Rory Boyle, Mabel Seto, Diana Townsend, Danielle Mayblyum, Emma Thibault, Heidi I L Jacobs, Michelle Farrell, Jennifer S Rabin, Kate Papp, Rebecca Amariglio, Suzanne Baker, Cristina Lois, Dorene Rentz, Julie Price, Aaron Schultz, Michael Properzi, Keith Johnson, Reisa Sperling, Rachel F Buckley","doi":"10.1126/sciadv.adt1288","DOIUrl":"10.1126/sciadv.adt1288","url":null,"abstract":"Elucidating the downstream impact of exogenous hormones on the aging brain will have far-reaching consequences for understanding why Alzheimer's disease (AD) predominates in women almost twofold over men. We tested the extent to which menopausal hormone therapy (HT) use is associated with later-life amyloid-β (Aβ) and tau accumulation using PET on N = 146 baseline clinically normal women, aged 51 to 89 years. Women were scanned over a 4.5-year (SD, 2.1; range, 1.3 to 10.4) and 3.5-year (SD, 1.5; range, 1.2 to 8.1) period for Aβ and tau, respectively, ~14 years after the initiation of HT. In older women (aged >70 years), HT users exhibited faster regional tau accumulation relative to non-users, localized to the entorhinal cortex and the inferior temporal and fusiform gyri, with an indirect effect of HT on cognitive decline through regional tau accumulation. In younger women (aged <70 years), HT associations with tau accumulation were negligible. Findings are relevant for optimizing menopausal treatment guidelines.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eadt1288"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of ferroelectricity in an antiferromagnetic vanadium trichloride monolayer.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.ado6538

Jinghao Deng, Deping Guo, Yao Wen, Shuangzan Lu, Hui Zhang, Zhengbo Cheng, Zemin Pan, Tao Jian, Dongyu Li, Hao Wang, Yusong Bai, Zhilin Li, Wei Ji, Jun He, Chendong Zhang

{"title":"Evidence of ferroelectricity in an antiferromagnetic vanadium trichloride monolayer.","authors":"Jinghao Deng, Deping Guo, Yao Wen, Shuangzan Lu, Hui Zhang, Zhengbo Cheng, Zemin Pan, Tao Jian, Dongyu Li, Hao Wang, Yusong Bai, Zhilin Li, Wei Ji, Jun He, Chendong Zhang","doi":"10.1126/sciadv.ado6538","DOIUrl":"10.1126/sciadv.ado6538","url":null,"abstract":"A reduced dimensionality of multiferroic materials is highly desired for device miniaturization, but the coexistence of ferroelectricity and magnetism at the two-dimensional limit is yet to be conclusively demonstrated. Here, we used a NbSe2 substrate to break both the C3 rotational and inversion symmetries in monolayer VCl3 and, thus, introduced exceptional in-plane ferroelectricity into a two-dimensional magnet. Scanning tunneling spectroscopy directly visualized ferroelectric domains and manipulated their domain boundaries in monolayer VCl3, where coexisting antiferromagnetic order with canted magnetic moments was verified by vibrating sample magnetometer measurements. Our density functional theory calculations highlight the crucial role that highly directional interfacial Cl-Se interactions play in breaking the symmetries and, thus, in introducing in-plane ferroelectricity, which was further verified by examining an ML-VCl3/graphene sample. Our work demonstrates an approach to manipulate the ferroelectric states in monolayered magnets through van der Waals interfacial interactions.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eado6538"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.adt5619

Cristina Ballesteros, María Paternina-Die, Magdalena Martínez-García, Gonzalo López-Montoya, Inés Noguero, Manuel Desco, Oscar Vilarroya, Daniel Martín de Blas, Susana Carmona

{"title":"Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala.","authors":"Cristina Ballesteros, María Paternina-Die, Magdalena Martínez-García, Gonzalo López-Montoya, Inés Noguero, Manuel Desco, Oscar Vilarroya, Daniel Martín de Blas, Susana Carmona","doi":"10.1126/sciadv.adt5619","DOIUrl":"10.1126/sciadv.adt5619","url":null,"abstract":"Childbirth is a life-changing event in a mother's life. While the transition to motherhood has recently been recognized as one of the most neuroplastic periods in adulthood, no study has yet explored whether the hippocampus and amygdala change during the peripartum in relation to childbirth experience and perinatal depression symptoms. In this longitudinal neuroimaging study, we assessed 88 first-time gestational mothers in late pregnancy and early postpartum and 30 nulliparous control women. We used optimized high-resolution MRI scans to quantify volumetric changes in the hippocampus and amygdala, along with their substructures. We found that increases in depression symptoms during the peripartum were positively correlated with changes in the right amygdala. A more challenging birth experience was associated with bilateral increases in hippocampal volume. These findings show that studying the neuroanatomical changes during the transition to motherhood can inform not only about adaptive processes but also about potential vulnerabilities, highlighting the importance of tracking perinatal experiences to enhance women's health.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eadt5619"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.adr7012

Andy Hinojo-Perez, Jodene Eldstrom, Ying Dou, Allan Marinho-Alcara, Michaela A Edmond, Alicia de la Cruz, Marta E Perez Rodriguez, Maykelis Diaz-Solares, Derek M Dykxhoorn, David Fedida, Rene Barro-Soria

{"title":"The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating.","authors":"Andy Hinojo-Perez, Jodene Eldstrom, Ying Dou, Allan Marinho-Alcara, Michaela A Edmond, Alicia de la Cruz, Marta E Perez Rodriguez, Maykelis Diaz-Solares, Derek M Dykxhoorn, David Fedida, Rene Barro-Soria","doi":"10.1126/sciadv.adr7012","DOIUrl":"10.1126/sciadv.adr7012","url":null,"abstract":"KCNQ2 channel subunits form part of the M-current and underlie one of the major potassium currents throughout the human nervous system, regulating resting membrane potentials, shaping action potentials, and impeding repetitive neuronal firing. However, how individual subunits within tetramers control channel functionality remains unresolved. Here, we investigate (i) whether opening of KCNQ2 channels requires a concerted step or can result from independent subunit activation and (ii) how individual subunits regulate gate opening and conductance. The E140R mutation in the S2 segment prevents activated voltage sensor conformations, but concatemeric constructs containing up to three E140R subunits retain KCNQ2-like currents. The underlying single-channel currents show subconductance levels resulting from limitations in inner gate dimensions, determined by the number of activated subunits and their spatial arrangement. Channel opening is allosteric and requires activation of only a single subunit, which can accentuate the influence of clinically relevant heterozygous mutations at threshold voltages.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eadr7012"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epstein-Barr virus infection promotes T cell dysregulation in a humanized mouse model of multiple sclerosis.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.adu5110

Jessica R Allanach, Naomi M Fettig, Blair K Hardman, Ariel R Rosen, Vina Fan, Cynthia Chung, Erin J Goldberg, Zachary J Morse, Iryna Shanina, Galina Vorobeychik, Lisa C Osborne, Marc S Horwitz

{"title":"Epstein-Barr virus infection promotes T cell dysregulation in a humanized mouse model of multiple sclerosis.","authors":"Jessica R Allanach, Naomi M Fettig, Blair K Hardman, Ariel R Rosen, Vina Fan, Cynthia Chung, Erin J Goldberg, Zachary J Morse, Iryna Shanina, Galina Vorobeychik, Lisa C Osborne, Marc S Horwitz","doi":"10.1126/sciadv.adu5110","DOIUrl":"10.1126/sciadv.adu5110","url":null,"abstract":"Latent infection with Epstein-Barr virus (EBV) is a strong risk factor for the development of multiple sclerosis (MS), although the underlying mechanisms remain unclear. To investigate this association, we induced experimental autoimmune encephalomyelitis (EAE) in immunodeficient mice reconstituted with peripheral blood mononuclear cells (PBMCs) from individuals with or without a history of EBV infection and/or relapsing MS (RRMS). HuPBMC EAE mice generated from EBV-seronegative healthy donors were less susceptible to developing severe neurological symptoms than healthy EBV-seropositive and RRMS donor groups. Donor EBV seropositivity and RRMS diagnosis were associated with a significant increase in the number of central nervous system (CNS) infiltrating effector T cells due to enhanced proliferation of proinflammatory T cells and limited expansion of regulatory T cells. The data indicate that a history of EBV infection, further compounded by a diagnosis of RRMS, promotes T cell-mediated xenogeneic CNS disease in a humanized mouse model of MS.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eadu5110"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.adr9395

Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang

{"title":"GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint.","authors":"Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang","doi":"10.1126/sciadv.adr9395","DOIUrl":"10.1126/sciadv.adr9395","url":null,"abstract":"As a member of the proton-sensing GPCR receptors, GPR132 plays a crucial role in regulating immune cell functions, but the mechanism by which GPR132 affects natural killer (NK) cells has not yet been reported. Here, RNA-seq displayed that the expression of GPR132 was reduced in activated NK cells, and the proportion of mature NK cells in GPR132-/- mice was substantially increased compared to WT mice, with stronger anti-melanoma capabilities. Further investigation indicates that GPR132-deficient NK92 cells expressed more GzmB and IFN-γ and exhibited stronger cytotoxicity. Mechanically, GPR132 regulates NK cell function through the CSK/ZAP70/NF-κB signaling axis. Down-regulation of GPR132 weakens the inhibition of NK cell function by lactate, thereby enhancing the functional execution of CAR-NK cells against colorectal cancer. These results highlight the previously unrecognized role of GPR132 in the regulation of NK cell function and that inhibition of GPR132 provided an updated insight for NK cell therapy.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eadr9395"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.adu0577

Masahiro Naganuma, Tomoya Kujirai, Haruhiko Ehara, Tamami Uejima, Tomoko Ito, Mie Goto, Mari Aoki, Masami Henmi, Sayako Miyamoto-Kohno, Mikako Shirouzu, Hitoshi Kurumizaka, Shun-Ichi Sekine

{"title":"Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome.","authors":"Masahiro Naganuma, Tomoya Kujirai, Haruhiko Ehara, Tamami Uejima, Tomoko Ito, Mie Goto, Mari Aoki, Masami Henmi, Sayako Miyamoto-Kohno, Mikako Shirouzu, Hitoshi Kurumizaka, Shun-Ichi Sekine","doi":"10.1126/sciadv.adu0577","DOIUrl":"10.1126/sciadv.adu0577","url":null,"abstract":"The metazoan transcription elongation complex (EC) of RNA polymerase II (RNAPII) generally stalls between the transcription start site and the first (+1) nucleosome. This promoter-proximal pausing involves negative elongation factor (NELF), 5,6-dichloro-1-β-d-ribobenzimidazole sensitivity-inducing factor (DSIF), and transcription elongation factor IIS (TFIIS) and is critical for subsequent productive transcription elongation. However, the detailed pausing mechanism and the involvement of the +1 nucleosome remain enigmatic. Here, we report cryo-electron microscopy structures of ECs stalled on nucleosomal DNA. In the absence of TFIIS, the EC is backtracked/arrested due to conflicts between NELF and the nucleosome. We identified two alternative binding modes of NELF, one of which reveals a critical contact with the downstream DNA through the conserved NELF-E basic helix. Upon binding with TFIIS, the EC progressed to the nucleosome to establish a paused EC with a partially unwrapped nucleosome. This paused EC strongly restricts EC progression further downstream. These structures illuminate the mechanism of RNAPII pausing/stalling at the +1 nucleosome.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eadu0577"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two paradoxes in women's well-being.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.adt1646

Caspar Kaiser, Naomi Muggleton, Edika Quispe-Torreblanca, Jan-Emmanuel De Neve

引用次数: 0

A natural biomimetic prosthetic hand with neuromorphic tactile sensing for precise and compliant grasping.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-07 Epub Date: 2025-03-05 DOI: 10.1126/sciadv.adr9300

Sriramana Sankar, Wen-Yu Cheng, Jinghua Zhang, Ariel Slepyan, Mark M Iskarous, Rebecca J Greene, Rene DeBrabander, Junjun Chen, Arnav Gupta, Nitish V Thakor

{"title":"A natural biomimetic prosthetic hand with neuromorphic tactile sensing for precise and compliant grasping.","authors":"Sriramana Sankar, Wen-Yu Cheng, Jinghua Zhang, Ariel Slepyan, Mark M Iskarous, Rebecca J Greene, Rene DeBrabander, Junjun Chen, Arnav Gupta, Nitish V Thakor","doi":"10.1126/sciadv.adr9300","DOIUrl":"10.1126/sciadv.adr9300","url":null,"abstract":"The human hand's hybrid structure combines soft and rigid anatomy to provide strength and compliance for versatile object grasping. Tactile sensing by skin mechanoreceptors enables precise and dynamic manipulation. Attempts to replicate the human hand have fallen short of a true biomimetic hybrid robotic hand with tactile sensing. We introduce a natural prosthetic hand composed of soft robotic joints and a rigid endoskeleton with three independent neuromorphic tactile sensing layers inspired by human physiology. Our innovative design capitalizes on the strengths of both soft and rigid robots, enabling the hybrid robotic hand to compliantly grasp numerous everyday objects of varying surface textures, weight, and compliance while differentiating them with 99.69% average classification accuracy. The hybrid robotic hand with multilayered tactile sensing achieved 98.38% average classification accuracy in a texture discrimination task, surpassing soft robotic and rigid prosthetic fingers. Controlled via electromyography, our transformative prosthetic hand allows individuals with upper-limb loss to grasp compliant objects with precise surface texture detection.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 10","pages":"eadr9300"},"PeriodicalIF":11.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0