Science Advances最新文献_第2页

Skillful multiyear prediction of flood frequency along the US Northeast Coast using a high-resolution modeling system 使用高分辨率建模系统对美国东北海岸洪水频率进行多年预测

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.ads4419

Liping Zhang, Thomas L. Delworth, Vimal Koul, Andrew Ross, Charles Stock, Xiaosong Yang, Fanrong Zeng, Andrew Wittenberg, Jian Zhao, Qinxue Gu, Shouwei Li

{"title":"Skillful multiyear prediction of flood frequency along the US Northeast Coast using a high-resolution modeling system","authors":"Liping Zhang, Thomas L. Delworth, Vimal Koul, Andrew Ross, Charles Stock, Xiaosong Yang, Fanrong Zeng, Andrew Wittenberg, Jian Zhao, Qinxue Gu, Shouwei Li","doi":"10.1126/sciadv.ads4419","DOIUrl":"10.1126/sciadv.ads4419","url":null,"abstract":"<div >Using tide gauge (TG) observations, we identify pronounced multidecadal fluctuations in sea level along the US Northeast Coast (USNEC) superimposed on a long-term increasing trend. This multidecadal sea level variability, largely arising from fluctuations in the buoyancy-driven Atlantic meridional overturning circulation (AMOC), substantially modulates the frequency of flood occurrences along the USNEC and serves as a source of multiyear predictability. Using an initialized dynamical downscaling decadal prediction system with a <sup>1</sup>/<sub>12</sub>° ocean resolution, we demonstrate that flood frequency along the USNEC can be predicted on multiyear to decadal timescales. The long-term increasing trend in flood frequency, mainly driven by increasing greenhouse gases and associated radiative forcing changes, can be predicted a decade ahead. Furthermore, detrended flood frequency along the USNEC exhibits prediction skill for up to 3 years, as verified by TG observation. This multiyear prediction skill is achieved using prediction models that are initialized from our best estimate of observed AMOC.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads4419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unidirectional molecular rotary motor with remotely switchable rotation direction 单向分子旋转马达，可远程切换旋转方向

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.adt8008

Kamil Szychta, Wojciech Danowski, Joanna Jankowska

引用次数: 0

Oxide semiconductor in a neuromorphic chromaticity communication loop for extreme environment exploration 用于极端环境探索的神经形态色度通信环路中的氧化物半导体

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.adu3576

Shangda Qu, Qianbo Yu, Chengpeng Jiang, Taoyu Zou, Honghuan Xu, Longlong Zhang, Mengze Tao, Qingshan Zhu, Song Zhang, Cong Geng, Mingjian Yuan, Yong-Young Noh, Wentao Xu

{"title":"Oxide semiconductor in a neuromorphic chromaticity communication loop for extreme environment exploration","authors":"Shangda Qu, Qianbo Yu, Chengpeng Jiang, Taoyu Zou, Honghuan Xu, Longlong Zhang, Mengze Tao, Qingshan Zhu, Song Zhang, Cong Geng, Mingjian Yuan, Yong-Young Noh, Wentao Xu","doi":"10.1126/sciadv.adu3576","DOIUrl":"10.1126/sciadv.adu3576","url":null,"abstract":"<div >Space exploration, particularly in the extreme space environment, has gained increasing attention. Networked robots capable of real-time environmental perception and autonomous collaboration offer a promising alternative for executing complex precision tasks. Consequently, achieving local reliable communication and preparing irradiation-tolerant materials are essential. Here, we demonstrate a cephalopod-inspired neuromorphic loop that enables chromaticity communication between individual near-sensor processing units. A programmatically aligned aluminum zinc oxide nanofiber array was fabricated and used as conductive channels that can withstand prolonged (~10<sup>4</sup> seconds) and high-dose (~5 × 10<sup>15</sup> ions per square centimeter) proton irradiation. The neuromorphic loop, with capabilities in environmental perception, event-driven processing, adaptive learning, and chromaticity communication, enables the self-driven collaboration of robotic hands based on tactile feedback and ensures reliable mobile links for drone flight control. This work pioneers a direction in neuromorphic visible light communication and marks important progress in the field of biomimetic intelligence.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu3576","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of bacterial operons during genome-wide stresses is influenced by premature terminations and internal promoters 细菌操纵子在全基因组胁迫过程中的动力学受到过早终止和内部启动子的影响

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.adl3570

Rahul Jagadeesan, Suchintak Dash, Cristina S. D. Palma, Ines S. C. Baptista, Vatsala Chauhan, Jarno Mäkelä, Andre S. Ribeiro

{"title":"Dynamics of bacterial operons during genome-wide stresses is influenced by premature terminations and internal promoters","authors":"Rahul Jagadeesan, Suchintak Dash, Cristina S. D. Palma, Ines S. C. Baptista, Vatsala Chauhan, Jarno Mäkelä, Andre S. Ribeiro","doi":"10.1126/sciadv.adl3570","DOIUrl":"10.1126/sciadv.adl3570","url":null,"abstract":"<div >Bacterial gene networks have operons, each coordinating several genes under a primary promoter. Half of the operons in <i>Escherichia coli</i> have been reported to also contain internal promoters. We studied their role during genome-wide stresses targeting key transcription regulators, RNA polymerase (RNAP) and gyrase. Our results suggest that operons’ responses are influenced by stress-related changes in premature elongation terminations and internal promoters’ activity. Globally, this causes the responses of genes in the same operon to differ with the distance between them in a wave-like pattern. Meanwhile, premature terminations are affected by positive supercoiling buildup, collisions between elongating and promoter-bound RNAPs, and local regulatory elements. We report similar findings in <i>E. coli</i> under other stresses and in evolutionarily distant bacteria <i>Bacillus subtilis</i>, <i>Corynebacterium glutamicum</i>, and <i>Helicobacter pylori</i>. Our results suggest that the strength, number, and positioning of operons’ internal promoters might have evolved to compensate for premature terminations, providing distal genes similar response strengths.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adl3570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection 绵羊是日本脑炎病毒的扩增宿主，增加了人类感染的风险

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.ads7441

Hailong Zhang, Dan Li, Jiayang Zheng, Jingyue Bao, Zhiliang Wang, Yafeng Qiu, Ke Liu, Zongjie Li, Beibei Li, Donghua Shao, Juxiang Liu, Zhiyong Ma, Jianchao Wei

{"title":"Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection","authors":"Hailong Zhang, Dan Li, Jiayang Zheng, Jingyue Bao, Zhiliang Wang, Yafeng Qiu, Ke Liu, Zongjie Li, Beibei Li, Donghua Shao, Juxiang Liu, Zhiyong Ma, Jianchao Wei","doi":"10.1126/sciadv.ads7441","DOIUrl":"10.1126/sciadv.ads7441","url":null,"abstract":"<div >The transmission cycle of Japanese encephalitis virus (JEV), involving pigs and birds as amplifying hosts and mosquitoes as vectors, was elucidated in the 1950s. However, factors contributing to this cycle remain unclear. Here, sheep were infected with a JEV strain isolated from sheep exhibiting neurological symptoms. The results revealed that sheep are susceptible to JEV infection and develop viremia, with levels and duration comparable to those observed in pigs, a known JEV-amplifying host. Mosquitoes fed viremic sheep blood showed an infection rate of 40.6 to 57.1%. These findings indicate that sheep can serve as amplifying hosts for JEV, potentially contributing to JEV transmission and increasing the public health risk of human infections. We propose an alternative, sheep-associated rural domestic JEV transmission cycle, which may be prevalent in specific regions where sheep are bred but pigs are not. This cycle exists along with the well-known pig-associated rural domestic and bird-associated wild cycles.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads7441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila Hsc70-4：果蝇dsRNA内化的一个意想不到的中介

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.adv1286

Sabrina J. Fletcher, Eugenia S. Bardossy, Lorena Tomé-Poderti, Thomas Moss, Vanesa Mongelli, Lionel Frangeul, Hervé Blanc, Yann Verdier, Joelle Vinh, Shaeri Mukherjee, Maria-Carla Saleh

{"title":"Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila","authors":"Sabrina J. Fletcher, Eugenia S. Bardossy, Lorena Tomé-Poderti, Thomas Moss, Vanesa Mongelli, Lionel Frangeul, Hervé Blanc, Yann Verdier, Joelle Vinh, Shaeri Mukherjee, Maria-Carla Saleh","doi":"10.1126/sciadv.adv1286","DOIUrl":"10.1126/sciadv.adv1286","url":null,"abstract":"<div >The small interfering RNA pathway is the primary antiviral defense mechanism in invertebrates and plants. This systemic mechanism relies on the recognition, transport, and internalization of double-stranded RNA (dsRNA). Our aim was to identify cell surface proteins that bind extracellular dsRNA and mediate its internalization in <i>Drosophila</i> cells. We used coimmunoprecipitation coupled with proteomics analysis and found that silencing heat shock cognate protein 70-4 (Hsc70-4), a constitutively expressed heat shock protein, impairs dsRNA internalization. Unexpectedly, despite lacking a predicted transmembrane domain, Hsc70-4 localizes to the cell membrane via lipid interactions. Antibody blocking experiments revealed an extracellular domain on Hsc70-4 that is essential for dsRNA internalization. Intriguingly, this dsRNA-specific binding capacity of Hsc70-4 functions independently of its chaperone activity. These findings not only highlight Hsc70-4 as a previously uncharacterized and essential component in the dsRNA internalization process but also offer promising insights for advancing RNA interference–based technologies to combat pests and vector-borne diseases.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv1286","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustofluidic spin control for 3D particle manipulation in droplets 液滴中三维粒子操纵的声流自旋控制

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.adx0269

Chuyi Chen, Yuyang Gu, Joseph Rufo, Jinxin Zhang, Kaichun Yang, Ying Chen, Luke P. Lee, Tony Jun Huang

{"title":"Acoustofluidic spin control for 3D particle manipulation in droplets","authors":"Chuyi Chen, Yuyang Gu, Joseph Rufo, Jinxin Zhang, Kaichun Yang, Ying Chen, Luke P. Lee, Tony Jun Huang","doi":"10.1126/sciadv.adx0269","DOIUrl":"10.1126/sciadv.adx0269","url":null,"abstract":"<div >The rotation of objects and corresponding dynamic systems plays a critical role in applications ranging from microscale droplet-based biochemical assays to nanoscale fluid transport and targeted drug delivery. However, directly observing and controlling these rotational phenomena across these different scales remains a challenge. Here, we introduce an acoustofluidic spinning control method that dynamically guides particles into three-dimensional, periodic spatial patterns within a droplet. Using surface acoustic waves, we induce internal streaming that generates centrifugal forces counteracted by surface tension, leading to the formation of rotating Stokes waves along the droplet’s equator. We show that fluid motion inside the droplet couples with these rotating waves, giving rise to a controllable superimposed helical particle orbit. These findings provide a platform for controlled rotational flows with potential applications in droplet-based microfluidics, biochemical processing, and tunable particle transport in lab-on-a-chip systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx0269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreasing importance of carbon-climate feedbacks in the Southern Ocean in a warming climate 在气候变暖的情况下，南大洋碳-气候反馈的重要性正在下降

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.adr3589

Tereza Jarníková, Corinne Le Quéré, Steven Rumbold, Colin Jones

引用次数: 0

Single rhenium atoms on nanomagnetite: Probing the recharge process that controls the fate of rhenium in the environment 纳米磁铁矿上的单个铼原子：探索控制环境中铼命运的充电过程

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.adq3650

Rongrong Ding, Carolina Guida, Carolyn I. Pearce, Elke Arenholz, Jean-Marc Grenèche, Alexandre Gloter, Andreas C. Scheinost, Kristina O. Kvashnina, Kaifeng Wang, Alejandro Fernandez-Martinez, Yang Mu, Kevin M. Rosso, Laurent Charlet

{"title":"Single rhenium atoms on nanomagnetite: Probing the recharge process that controls the fate of rhenium in the environment","authors":"Rongrong Ding, Carolina Guida, Carolyn I. Pearce, Elke Arenholz, Jean-Marc Grenèche, Alexandre Gloter, Andreas C. Scheinost, Kristina O. Kvashnina, Kaifeng Wang, Alejandro Fernandez-Martinez, Yang Mu, Kevin M. Rosso, Laurent Charlet","doi":"10.1126/sciadv.adq3650","DOIUrl":"10.1126/sciadv.adq3650","url":null,"abstract":"<div >Understanding the redox transitions that control rhenium geochemistry is central to paleoredox and geochronology studies, as well as predicting the fate of chemically similar hazardous oxyanions in the environment such as pertechnetate. However, detailed mechanistic information regarding rhenium redox transitions in anoxic systems is scarce. Here, we performed a comprehensive laboratory study of rhenium redox transitions on variably oxidized magnetite nanoparticle surfaces. Through high-end spectroscopic and microscopic tools, we propose an abiotic transition pathway in which aqueous iron(II) ions in the presence of pure or preoxidized magnetite serve as an electron source to reduce rhenium(VII) to individual rhenium(IV) atoms or small polynuclear species on nanoparticle surfaces. Notably, iron(II) ions recharged preoxidized magnetite nanoparticles exhibit a maghemite core and a magnetite shell, challenging the traditional core-shell magnetite-maghemite model. This study provides a fundamental understanding of redox processes governing rhenium fate and transport in the environment and enables an improved basis for predicting its speciation in geochemical systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq3650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual DNA demethylation mechanisms implement epigenetic memory driven by the pioneer factor PAX7 双DNA去甲基化机制实现由先驱因子PAX7驱动的表观遗传记忆

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-16 DOI: 10.1126/sciadv.adu6632

Juliette Harris, Alexandre Mayran, Arthur Gouhier, Yves Gauthier, Nawal Hajj Sleiman, Samir Merabet, Michael Dukatz, Pavel Bashtrykov, Albert Jeltsch, Haig Djambazian, Shu-Huang Chen, Aurelio Balsalobre, Jacques Drouin

{"title":"Dual DNA demethylation mechanisms implement epigenetic memory driven by the pioneer factor PAX7","authors":"Juliette Harris, Alexandre Mayran, Arthur Gouhier, Yves Gauthier, Nawal Hajj Sleiman, Samir Merabet, Michael Dukatz, Pavel Bashtrykov, Albert Jeltsch, Haig Djambazian, Shu-Huang Chen, Aurelio Balsalobre, Jacques Drouin","doi":"10.1126/sciadv.adu6632","DOIUrl":"10.1126/sciadv.adu6632","url":null,"abstract":"<div >Pioneer transcription factors have the unique ability to open chromatin at enhancers to implement new cell fates. They also provide epigenetic memory through demethylation of enhancer DNA, but the underlying mechanisms remain unclear. We now show that the pioneer paired box 7 (PAX7) triggers DNA demethylation using two replication-dependent mechanisms, including direct PAX7 interaction with the E3 ubiquitin-protein ligase (UHRF1)-DNA methyltransferase 1 (DNMT1) complex that is responsible for DNA methylation maintenance. PAX7 binds to UHRF1 and prevents its interaction with DNMT1, thus blocking activation of its enzyme activity. The ten-eleven translocation DNA dioxygenase (TET) DNA demethylases also contribute to the replication-dependent loss of DNA methylation. Thus, PAX7 hijacks UHRF1 to block activation of DNMT1 after replication, leading to loss of DNA methylation by dilution, and the process is assisted by the action of TET demethylases.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu6632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0