Science Advances最新文献_第2页

Mechanotransduction governs CD40 function and underlies X-linked hyper-IgM syndrome 机械传导控制着 CD40 的功能，是 X 连锁高 IgM 综合征的基础

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adl5815

Hyun-Kyu Choi, Stefano Travaglino, Matthias Münchhalfen, Richard Görg, Zhe Zhong, Jintian Lyu, David M. Reyes-Aguilar, Jürgen Wienands, Ankur Singh, Cheng Zhu

{"title":"Mechanotransduction governs CD40 function and underlies X-linked hyper-IgM syndrome","authors":"Hyun-Kyu Choi, Stefano Travaglino, Matthias Münchhalfen, Richard Görg, Zhe Zhong, Jintian Lyu, David M. Reyes-Aguilar, Jürgen Wienands, Ankur Singh, Cheng Zhu","doi":"10.1126/sciadv.adl5815","DOIUrl":"10.1126/sciadv.adl5815","url":null,"abstract":"<div >B cell maturation depends on cognate interactions between the T and B cells. Upon interaction with CD40 ligand (CD40L) on T cells, CD40 delivers costimulatory signals alongside B cell antigen receptor (BCR) signaling to regulate affinity maturation and antibody class switch. Mutations affecting CD40-CD40L interactions cause abnormal antibody responses in immunodeficiencies known as X-linked hyper-IgM syndrome (X-HIgM). Here, we study the CD40-mediated mechanotransduction in B cells, which likely occurs during their physical contacts with T cells. We found that CD40 forms catch bond with CD40L that lasts longer at larger forces, both B and T cells exert tension on CD40-CD40L bonds, and force enhances CD40 signaling and antibody class switch. X-HIgM CD40L mutations impair catch bond formation, suppress endogenous tension, and reduce force-enhanced CD40 signaling, leading to deficiencies in antibody class switch. Our findings highlight the role of mechanotransduction in CD40 function and provide insights into the mechanisms underlying X-HIgM syndrome.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adl5815","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The HDAC6 inhibitor AVS100 (SS208) induces a pro-inflammatory tumor microenvironment and potentiates immunotherapy HDAC6 抑制剂 AVS100 (SS208) 能诱导促炎性肿瘤微环境并增强免疫疗法的效果

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adp3687

Damian Kovalovsky, Satish Noonepalle, Manasa Suresh, Dileep Kumar, Michael Berrigan, Nithya Gajendran, Sumit Upadhyay, Anelia Horvath, Allen Kim, David Quiceno-Torres, Karthik Musunuri, Alejandro Villagra

{"title":"The HDAC6 inhibitor AVS100 (SS208) induces a pro-inflammatory tumor microenvironment and potentiates immunotherapy","authors":"Damian Kovalovsky, Satish Noonepalle, Manasa Suresh, Dileep Kumar, Michael Berrigan, Nithya Gajendran, Sumit Upadhyay, Anelia Horvath, Allen Kim, David Quiceno-Torres, Karthik Musunuri, Alejandro Villagra","doi":"10.1126/sciadv.adp3687","DOIUrl":"10.1126/sciadv.adp3687","url":null,"abstract":"<div >Histone deacetylase 6 (HDAC6) inhibition is associated with an increased pro-inflammatory tumor microenvironment and antitumoral immune responses. Here, we show that the HDAC6 inhibitor AVS100 (SS208) had an antitumoral effect in SM1 melanoma and CT26 colon cancer models and increased the efficacy of anti–programmed cell death protein 1 treatment, leading to complete remission in melanoma and increased response in colon cancer. AVS100 treatment increased pro-inflammatory tumor-infiltrating macrophages and CD8 effector T cells with an inflammatory and T cell effector gene signature. Acquired T cell immunity and long-term protection were evidenced as increased immunodominant T cell clones after AVS100 treatment. Last, AVS100 showed no mutagenicity, toxicity, or adverse effects in preclinical good laboratory practice studies, part of the package that has led to US Food and Drug Administration clearance of an investigational new drug application for initiating clinical trials. This would be a first-in-human combination therapy of pembrolizumab with HDAC6 inhibition for locally advanced or metastatic solid tumors.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp3687","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechano-gradients drive morphogen-noise correction to ensure robust patterning 机械梯度驱动形态发生器噪声校正，确保稳健的图案形成

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adp2357

Kana Aoki, Taiki Higuchi, Yuki Akieda, Kotone Matsubara, Yasuyuki Ohkawa, Tohru Ishitani

引用次数: 0

Archaeal type six secretion system mediates contact-dependent antagonism 古细菌六型分泌系统介导依赖接触的拮抗作用

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adp7088

Tobias Zachs, Jessie James L. Malit, Jingwei Xu, Alexandra Schürch, Shamphavi Sivabalasarma, Phillip Nußbaum, Sonja-Verena Albers, Martin Pilhofer

{"title":"Archaeal type six secretion system mediates contact-dependent antagonism","authors":"Tobias Zachs, Jessie James L. Malit, Jingwei Xu, Alexandra Schürch, Shamphavi Sivabalasarma, Phillip Nußbaum, Sonja-Verena Albers, Martin Pilhofer","doi":"10.1126/sciadv.adp7088","DOIUrl":"10.1126/sciadv.adp7088","url":null,"abstract":"<div >Microbial communities are shaped by cell-cell interactions. Although archaea are often found in associations with other microorganisms, the mechanisms structuring these communities are poorly understood. Here, we report on the structure and function of haloarchaeal contractile injection systems (CISs). Using a combination of functional assays and time-lapse imaging, we show that <i>Halogeometricum borinquense</i> exhibits antagonism toward <i>Haloferax volcanii</i> by inducing cell lysis and inhibiting proliferation. This antagonism is contact-dependent and requires a functional CIS, which is encoded by a gene cluster that is associated with toxin-immunity pairs. Cryo–focused ion beam milling and imaging by cryo–electron tomography revealed that these CISs are bound to the cytoplasmic membrane, resembling the bacterial type six secretion systems (T6SSs). We show that related T6SS gene clusters are conserved and expressed in other haloarchaeal strains, which exhibit antagonistic behavior. Our data provide a mechanistic framework for understanding how archaea may shape microbial communities and affect the food webs they inhabit.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp7088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B cell adapter for PI 3-kinase (BCAP) coordinates antigen internalization and trafficking through the B cell receptor PI 3-激酶的 B 细胞适配器 (BCAP) 协调抗原内化和通过 B 细胞受体的运输

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adp1747

Jonathan Lagos, Ursula Holder, Sara Sagadiev, Andrea Montiel-Armendariz, Lucy Z. Li, Chandrashekhar Pasare, Baidong Hou, Jessica A. Hamerman, Mridu Acharya

{"title":"B cell adapter for PI 3-kinase (BCAP) coordinates antigen internalization and trafficking through the B cell receptor","authors":"Jonathan Lagos, Ursula Holder, Sara Sagadiev, Andrea Montiel-Armendariz, Lucy Z. Li, Chandrashekhar Pasare, Baidong Hou, Jessica A. Hamerman, Mridu Acharya","doi":"10.1126/sciadv.adp1747","DOIUrl":"10.1126/sciadv.adp1747","url":null,"abstract":"<div >B cell adapter for PI 3-kinase (BCAP) is an adaptor molecule associated with signaling through multiple immune receptors, including the B cell receptor (BCR). However, B cell–intrinsic role of BCAP in antibody responses is unclear. We investigated the role of BCAP in B cell response to viral particles and found a previously unidentified mechanism by which BCAP regulates antigen-specific responses. B cell–specific deletion of BCAP in mice leads to decreases in antigen-specific responses through defects in BCR-antigen endocytosis. BCAP is necessary to orchestrate actin reorganization around the antigen for efficient endocytosis through BCR and intracellular processing of antigens. Therefore, loss of BCAP from B cells leads to defects in antigen endocytosis, hampering the propagation of antigen-derived signals and decreasing the ability of B cells to present antigens to T cells. Thus, our study clarifies how BCAP regulates B cell responses to complex antigens and elucidates that antigen positioning inside B cells determines different B cell activation outcomes.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp1747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological cost of antibiotic resistance: Insights from a ribosome variant in bacteria 抗生素耐药性的生理代价：细菌核糖体变异的启示

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adq5249

Eun Chae Moon, Tushar Modi, Dong-yeon D. Lee, Danis Yangaliev, Jordi Garcia-Ojalvo, S. Banu Ozkan, Gürol M. Süel

{"title":"Physiological cost of antibiotic resistance: Insights from a ribosome variant in bacteria","authors":"Eun Chae Moon, Tushar Modi, Dong-yeon D. Lee, Danis Yangaliev, Jordi Garcia-Ojalvo, S. Banu Ozkan, Gürol M. Süel","doi":"10.1126/sciadv.adq5249","DOIUrl":"10.1126/sciadv.adq5249","url":null,"abstract":"<div >Antibiotic-resistant ribosome variants arise spontaneously in bacterial populations; however, their impact on the overall bacterial physiology remains unclear. We studied the naturally arising antibiotic-resistant L22* ribosome variant of <i>Bacillus subtilis</i> and identified a Mg<sup>2+</sup>-dependent physiological cost. Coculture competition experiments show that Mg<sup>2+</sup> limitation hinders the growth of the L22* variant more than the wild type (WT), even under antibiotic pressure. This growth disadvantage of L22* cells is not due to lower ribosome abundance but rather due to reduced intracellular Mg<sup>2+</sup> levels. Coarse-grained elastic-network modeling of ribosome conformational dynamics suggests that L22* ribosomes associate more tightly with Mg<sup>2+</sup> when compared to WT. We combined the structural modeling and experimental measurements in a steady-state model to predict cellular adenosine 5′-triphosphate (ATP) levels, which also depend on Mg<sup>2+</sup>. Experiments confirmed a predicted ATP drop in L22* cells under Mg<sup>2+</sup> limitation, while WT cells were less affected. Intracellular competition for a finite Mg<sup>2+</sup> pool can thus suppress the establishment of an antibiotic-resistant ribosome variant.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq5249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H2S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response H 2 S-Prdx4 轴减轻高尔基体应激反应，增强肿瘤反应性 T 细胞免疫治疗反应

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adp1152

Nathaniel Oberholtzer, Paramita Chakraborty, Mohamed Faisal Kassir, James Dressman, Satyajit Das, Stephanie Mills, Susana Comte-Walters, Monika Gooz, Seungho Choi, Rasesh Y. Parikh, Zacharia Hedley, Silvia Vaena, Reid DeMass, Gina Scurti, Martin Romeo, Vamsi K. Gangaraju, Stefano Berto, Elizabeth Hill, Lauren E. Ball, Anand S. Mehta, Eduardo N. Maldonado, Michael I. Nishimura, Besim Ogretmen, Shikhar Mehrotra

{"title":"H2S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response","authors":"Nathaniel Oberholtzer, Paramita Chakraborty, Mohamed Faisal Kassir, James Dressman, Satyajit Das, Stephanie Mills, Susana Comte-Walters, Monika Gooz, Seungho Choi, Rasesh Y. Parikh, Zacharia Hedley, Silvia Vaena, Reid DeMass, Gina Scurti, Martin Romeo, Vamsi K. Gangaraju, Stefano Berto, Elizabeth Hill, Lauren E. Ball, Anand S. Mehta, Eduardo N. Maldonado, Michael I. Nishimura, Besim Ogretmen, Shikhar Mehrotra","doi":"10.1126/sciadv.adp1152","DOIUrl":"10.1126/sciadv.adp1152","url":null,"abstract":"<div >The role of tumor microenvironment (TME)–associated inadequate protein modification and trafficking due to insufficiency in Golgi function, leading to Golgi stress, in the regulation of T cell function is largely unknown. Here, we show that disruption of Golgi architecture under TME stress, identified by the decreased expression of GM130, was reverted upon treatment with hydrogen sulfide (H<sub>2</sub>S) donor GYY4137 or overexpressing cystathionine β-synthase (CBS), an enzyme involved in the biosynthesis of endogenous H<sub>2</sub>S, which also promoted stemness, antioxidant capacity, and increased protein translation, mediated in part by endoplasmic reticulum–Golgi shuttling of Peroxiredoxin-4. In in vivo models of melanoma and lymphoma, antitumor T cells conditioned ex vivo with exogenous H<sub>2</sub>S or overexpressing CBS demonstrated superior tumor control upon adoptive transfer. Further, T cells with high Golgi content exhibited unique metabolic and glycation signatures with enhanced antitumor capacity. These data suggest that strategies to mitigate Golgi network stress or using Golgi<sup>hi</sup> tumor-reactive T cells can improve tumor control upon adoptive transfer.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp1152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamical control of nanoscale electron density in atomically thin n-type semiconductors via nano-electric pulse generator 通过纳米电脉冲发生器动态控制原子薄 n 型半导体中的纳米级电子密度

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adr0492

Sujeong Kim, Hyeongwoo Lee, Seonhye Eom, Gangseon Ji, Soo Ho Choi, Huitae Joo, Jinhyuk Bae, Ki Kang Kim, Hyeong-Ryeol Park, Kyoung-Duck Park

{"title":"Dynamical control of nanoscale electron density in atomically thin n-type semiconductors via nano-electric pulse generator","authors":"Sujeong Kim, Hyeongwoo Lee, Seonhye Eom, Gangseon Ji, Soo Ho Choi, Huitae Joo, Jinhyuk Bae, Ki Kang Kim, Hyeong-Ryeol Park, Kyoung-Duck Park","doi":"10.1126/sciadv.adr0492","DOIUrl":"10.1126/sciadv.adr0492","url":null,"abstract":"<div >Controlling electron density in two-dimensional semiconductors is crucial for both comprehensive understanding of fundamental material properties and their technological applications. However, conventional electrostatic doping methods exhibit limitations, particularly in addressing electric field–induced drift and subsequent diffusion of electrons, which restrict nanoscale doping. Here, we present a tip-induced nanospectroscopic electric pulse modulator to dynamically control nanoscale electron density, thereby facilitating precise measurement of nano-optoelectronic behaviors within a MoS<sub>2</sub> monolayer. The tip-induced electric pulse enables nanoscale modulation of electron distribution as a function of electric pulse width. We simultaneously investigate spatially altering photoluminescence quantum yield at the nanoscale region. We model the extent of electron depletion region, confirming a minimum doping region with a radius of ∼265 nanometers for a 30-nanosecond pulse width. Our approach paves the way for engineering local electron density and in situ nano-optical characterization in two-dimensional materials, enabling an in-depth understanding of doping-dependent nano-optoelectronic phenomena.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr0492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing 细胞对细胞外基质粘性能量耗散的反应超过了高刚性感应

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adf9758

Carla Huerta-López, Alejandro Clemente-Manteca, Diana Velázquez-Carreras, Francisco M. Espinosa, Juan G. Sanchez, Álvaro Martínez-del-Pozo, María García-García, Sara Martín-Colomo, Andrea Rodríguez-Blanco, Ricardo Esteban-González, Francisco M. Martín-Zamora, Luis I. Gutierrez-Rus, Ricardo Garcia, Pere Roca-Cusachs, Alberto Elosegui-Artola, Miguel A. del Pozo, Elías Herrero-Galán, Pablo Sáez, Gustavo R. Plaza, Jorge Alegre-Cebollada

{"title":"Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing","authors":"Carla Huerta-López, Alejandro Clemente-Manteca, Diana Velázquez-Carreras, Francisco M. Espinosa, Juan G. Sanchez, Álvaro Martínez-del-Pozo, María García-García, Sara Martín-Colomo, Andrea Rodríguez-Blanco, Ricardo Esteban-González, Francisco M. Martín-Zamora, Luis I. Gutierrez-Rus, Ricardo Garcia, Pere Roca-Cusachs, Alberto Elosegui-Artola, Miguel A. del Pozo, Elías Herrero-Galán, Pablo Sáez, Gustavo R. Plaza, Jorge Alegre-Cebollada","doi":"10.1126/sciadv.adf9758","DOIUrl":"10.1126/sciadv.adf9758","url":null,"abstract":"<div >The mechanics of the extracellular matrix (ECM) determine cell activity and fate through mechanoresponsive proteins including Yes-associated protein 1 (YAP). Rigidity and viscous relaxation have emerged as the main mechanical properties of the ECM steering cell behavior. However, how cells integrate coexisting ECM rigidity and viscosity cues remains poorly understood, particularly in the high-stiffness regime. Here, we have exploited engineered stiff viscoelastic protein hydrogels to show that, contrary to current models of cell-ECM interaction, substrate viscous energy dissipation attenuates mechanosensing even when cells are exposed to higher effective rigidity. This unexpected behavior is however readily captured by a pull-and-hold model of molecular clutch–based cell mechanosensing, which also recapitulates opposite cellular response at low rigidities. Consistent with predictions of the pull-and-hold model, we find that myosin inhibition can boost mechanosensing on cells cultured on dissipative matrices. Together, our work provides general mechanistic understanding on how cells respond to the viscoelastic properties of the ECM.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adf9758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust generation of intrinsic C points with magneto-optical bound states in the continuum 利用连续体中的磁光束缚态稳健生成固有 C 点

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.ads0157

Wenjing Lv, Haoye Qin, Zengping Su, Chengzhi Zhang, Jiongpeng Huang, Yuzhi Shi, Bo Li, Patrice Genevet, Qinghua Song

{"title":"Robust generation of intrinsic C points with magneto-optical bound states in the continuum","authors":"Wenjing Lv, Haoye Qin, Zengping Su, Chengzhi Zhang, Jiongpeng Huang, Yuzhi Shi, Bo Li, Patrice Genevet, Qinghua Song","doi":"10.1126/sciadv.ads0157","DOIUrl":"10.1126/sciadv.ads0157","url":null,"abstract":"<div >C points, circular polarization in momentum space, play crucial roles in chiral wave manipulations. However, conventional approaches of achieving intrinsic C points using photonic crystals with broken symmetries suffer from a low <i>Q</i> factor and high sensitivity to structural geometry, rendering them fragile and susceptible to perturbations and disorders. We report magneto-optical (MO) bound states in the continuum (BICs) with a symmetry-preserved planar photonic crystal. We achieve intrinsic C points at Γ point that are robust against variation in both structural geometry and external magnetic field. MO coupling between two modes induces Zeeman splitting, leading to MO BICs and quasi-BICs with circular eigenstates for high-<i>Q</i> chiral responses. Furthermore, switchable C point handedness and circular dichroism are enabled by reversing the magnetic field. These findings unveil BICs and quasi-BICs with circular eigenstates and on-demand control of C points, paving the way for advanced chiral wave manipulation with enhanced light-matter interaction.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads0157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0