Science Advances最新文献_第10页

Using optical skyrmions to assess vectorial adaptive optics capabilities in the presence of complex aberrations 在复杂像差存在的情况下，使用光学天空来评估矢量自适应光学能力

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-03 DOI: 10.1126/sciadv.adv7904

Yifei Ma, Zimo Zhao, Yuanxing Shen, Binguo Chen, An Aloysius Wang, Yuxi Cai, Ji Qin, Runchen Zhang, Yunqi Zhang, Jiahe Cui, Bangshan Sun, Jiawen Li, Yuzhu Shi, Liangyu Deng, Honghui He, Lin Luo, Yonghong He, Yun Zhang, Ben Dai, Daniel J. Royston, Steve J. Elston, Stephen M. Morris, Martin J. Booth, Chao He

{"title":"Using optical skyrmions to assess vectorial adaptive optics capabilities in the presence of complex aberrations","authors":"Yifei Ma, Zimo Zhao, Yuanxing Shen, Binguo Chen, An Aloysius Wang, Yuxi Cai, Ji Qin, Runchen Zhang, Yunqi Zhang, Jiahe Cui, Bangshan Sun, Jiawen Li, Yuzhu Shi, Liangyu Deng, Honghui He, Lin Luo, Yonghong He, Yun Zhang, Ben Dai, Daniel J. Royston, Steve J. Elston, Stephen M. Morris, Martin J. Booth, Chao He","doi":"10.1126/sciadv.adv7904","DOIUrl":"10.1126/sciadv.adv7904","url":null,"abstract":"<div >With the growing use of optical polarization in applications ranging from communications to medical diagnoses, adaptive correction of complex vectorial aberrations in optical systems has become an increasingly important area of research. However, research to date has focused primarily on phase and retardance aberrations, whereas another major source of aberration—diattenuation—remains largely unexplored. Unlike the others, diattenuation affects intensity in addition to phase and polarization, limiting the intrinsic correction capability of adaptive systems. In this work, we propose the use of optical skyrmions to probe diattenuation-aberrated systems and provide metrics that characterize the performance of vectorial adaptive optics (V-AO), with theoretical and experimental validations. Based on the probed results, we demonstrate V-AO correction under real-world aberrations for complex media imaging and analyze correction strategies to optimize measurements in aberrated polarimetric systems. This work paves the way for high-dimensional aberration correction, introduces a previously unidentified use of optical skyrmions, and provides insights that will aid the development of vectorial measurement systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv7904","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1′-Cyanocytidine-5′-isobutyryl is a potent SARS-CoV-2 inhibitor in culture and infected Syrian hamsters 1′-Cyanocytidine-5′- isobutyyl在培养和感染的叙利亚仓鼠中是有效的SARS-CoV-2抑制剂

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-03 DOI: 10.1126/sciadv.adz5913

Franck Amblard, Mahesh Kasthuri, Julia C. LeCher, Sijia Tao, Ramyani De, Rana Abdelnabi, Ingrid Marko, Longhu Zhou, Chengwei Li, Junxing Shi, Shu Ling Goh, Jessica Downs-Bowen, Leda Bassit, Selwyn Hurwitz, Keivan Zandi, Tamara McBrayer, Birgit Weynand, Kenneth A. Johnson, Johan Neyts, Raymond F. Schinazi

{"title":"1′-Cyanocytidine-5′-isobutyryl is a potent SARS-CoV-2 inhibitor in culture and infected Syrian hamsters","authors":"Franck Amblard, Mahesh Kasthuri, Julia C. LeCher, Sijia Tao, Ramyani De, Rana Abdelnabi, Ingrid Marko, Longhu Zhou, Chengwei Li, Junxing Shi, Shu Ling Goh, Jessica Downs-Bowen, Leda Bassit, Selwyn Hurwitz, Keivan Zandi, Tamara McBrayer, Birgit Weynand, Kenneth A. Johnson, Johan Neyts, Raymond F. Schinazi","doi":"10.1126/sciadv.adz5913","DOIUrl":"10.1126/sciadv.adz5913","url":null,"abstract":"<div >The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 epidemic is relatively under control due to the rapid development and deployment of vaccines and a few drugs. However, challenges persist, as new variants and issues with vaccine durability may compromise their effectiveness. Here, we report the discovery and evaluation of 1′-cyanocytidine (CNC), a nontoxic, next-generation nucleoside analog that displays submicromolar inhibition of SARS-CoV-2 replication in various cell and 3D HAE-ALI primary culture systems. Intracellularly, CNC is metabolized to its active 5′-triphosphate form (CNC-TP), targeting the viral RNA–dependent RNA polymerase. Pre–steady-state kinetic analysis revealed CNC-TP is a reversible, competitive inhibitor. The 5′-isobutyryl ester prodrug of CNC (CN<i>iBu</i>C), which rapidly converts to CNC in mouse and hamster plasma, substantially reduced viral RNA levels and lung infectious virus titers in a Syrian hamster model after intraperitoneal and oral dosing. With favorable pharmacokinetics, bioavailability, and safety profiles, CNC and CN<i>iBu</i>C represent promising candidates for SARS-CoV-2 therapy.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz5913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limited phosphate resources are efficiently allocated to each organ by the PHR1-EIN3/EIL1 module to coordinate their establishment 有限的磷酸盐资源通过PHR1-EIN3/EIL1模块有效地分配到各个器官，以协调它们的建立

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-03 DOI: 10.1126/sciadv.adw7727

Fu-Huan Yu, Cheng-yue Gu, Yi-Bo Wang, Xin-Rong Mu, Qin-Xin Bao, Na Sai, Yonghua Yang, Jinliang Qi, Minkai Yang, Lai-Sheng Meng

{"title":"Limited phosphate resources are efficiently allocated to each organ by the PHR1-EIN3/EIL1 module to coordinate their establishment","authors":"Fu-Huan Yu, Cheng-yue Gu, Yi-Bo Wang, Xin-Rong Mu, Qin-Xin Bao, Na Sai, Yonghua Yang, Jinliang Qi, Minkai Yang, Lai-Sheng Meng","doi":"10.1126/sciadv.adw7727","DOIUrl":"10.1126/sciadv.adw7727","url":null,"abstract":"<div >Phosphate (Pi) is an essential nutrient that frequently limits plant growth because of its low availability in soils, especially during early seedling development in <i>Arabidopsis</i>. Under Pi-deficient conditions, etiolated seedlings exhibit elongated hypocotyls, shortened roots, and small, pale cotyledons—a morphological adaptation that enhances light-foraging capacity. However, how Pi is strategically distributed among these organs to optimize seedling establishment remains unclear. We here identify a PHR1-EIN3/EIL1 regulatory module that directs minimal Pi resources to suppress root elongation and cotyledon expansion or to accelerate greening, promoting Pi conservation. This mechanism prioritizes hypocotyl elongation to improve light acquisition. In contrast, under sufficient Pi supply, hypocotyl and root growth is promoted along with cotyledon enlargement, while greening is delayed. Thus, the PHR1-EIN3/EIL1 module enables efficient allocation of limited Pi to maximize hypocotyl elongation for light foraging during early seedling establishment while strategically restricting Pi usage in other organs to enhance overall survival.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal regulatory T cells persist into adulthood across multiple tissues with high enrichment in the skin 新生儿调节性T细胞在多个组织中持续存在到成年，在皮肤中高度富集

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-03 DOI: 10.1126/sciadv.adx8037

Morgane Hilaire, Angélina Mimoun, Léonie Cagnet, Rémy Villette, Aristeidis Roubanis, Hugo Sentenac, Benoît L. Salomon

{"title":"Neonatal regulatory T cells persist into adulthood across multiple tissues with high enrichment in the skin","authors":"Morgane Hilaire, Angélina Mimoun, Léonie Cagnet, Rémy Villette, Aristeidis Roubanis, Hugo Sentenac, Benoît L. Salomon","doi":"10.1126/sciadv.adx8037","DOIUrl":"10.1126/sciadv.adx8037","url":null,"abstract":"<div >Foxp3<sup>+</sup> regulatory T cells (T<sub>regs</sub>) reside in both lymphoid and nonlymphoid organs, where they play a crucial role in immune tolerance and tissue homeostasis. In mice, T<sub>regs</sub> begin colonizing these tissues shortly after birth, contributing to long-term immune response regulation therein. However, the kinetics of T<sub>reg</sub> generation across different tissues remains unclear. Here, we investigate T<sub>reg</sub> ontogeny from birth to adulthood in various tissues. In lymphoid organs, the adult T<sub>reg</sub> pool is continuously replenished with cells generated at different ages. In contrast, the skin retains a large fraction of T<sub>regs</sub> that colonize the tissue during the neonatal period, with minimal turnover in adulthood. The liver, lungs, and colon exhibit intermediate T<sub>reg</sub> renewal dynamics. Notably, neonatal T<sub>regs</sub> that persist into adulthood display a more activated phenotype and express markers associated with tissue-resident T<sub>regs</sub> and type 2 immunity. Our findings reveal tissue-specific differences in T<sub>reg</sub> generation kinetics and highlight a major phenotypic shift between neonatal and adult-derived T<sub>regs</sub>.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx8037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent and early 20th century destabilization of the subpolar North Atlantic recorded in bivalves 最近和20世纪初记录在双壳类动物中的北大西洋亚极地的不稳定

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-03 DOI: 10.1126/sciadv.adw3468

Beatriz Arellano-Nava, Timothy M. Lenton, Chris A. Boulton, Sarah Holmes, James Scourse, Paul G. Butler, David J. Reynolds, Tamara Trofimova, Pierre Poitevin, Alejandro Román-González, Paul R. Halloran

{"title":"Recent and early 20th century destabilization of the subpolar North Atlantic recorded in bivalves","authors":"Beatriz Arellano-Nava, Timothy M. Lenton, Chris A. Boulton, Sarah Holmes, James Scourse, Paul G. Butler, David J. Reynolds, Tamara Trofimova, Pierre Poitevin, Alejandro Román-González, Paul R. Halloran","doi":"10.1126/sciadv.adw3468","DOIUrl":"10.1126/sciadv.adw3468","url":null,"abstract":"<div >Climate change risks triggering abrupt weakening in two climatically important North Atlantic Ocean circulation elements, the subpolar gyre and the Atlantic Meridional Overturning Circulation (AMOC). Loss of AMOC stability has been inferred from slowing recovery of temperature and salinity fluctuations over time. However, observational datasets, constructed from records with sparse spatial and temporal coverage, may introduce substantial biases in stability indicators. Alternative records are therefore needed for reliable stability assessments. Here, using bivalve-derived environmental reconstructions, we show that the subpolar North Atlantic has experienced two destabilization episodes over the past ~150 years. The first preceded the rapid circulation changes associated with the 1920s North Atlantic regime shift, suggesting that a tipping point may have been crossed in the early 20th century. The second and stronger destabilization began around 1950 and continues to the present, supporting evidence of recent stability loss and suggesting that the region is moving toward a tipping point.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw3468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable mechanical metastructures modeling polydomain materials 可编程机械元结构建模多域材料

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-03 DOI: 10.1126/sciadv.adz9811

Yifan Yang, Xiaoliang Zhang, Ting Wang, Xinqi Lin, Fan Xu

{"title":"Programmable mechanical metastructures modeling polydomain materials","authors":"Yifan Yang, Xiaoliang Zhang, Ting Wang, Xinqi Lin, Fan Xu","doi":"10.1126/sciadv.adz9811","DOIUrl":"10.1126/sciadv.adz9811","url":null,"abstract":"<div >The orientation and distribution of microscopic units in polydomain materials contribute to their functionality and performance. However, within bulk materials from traditional synthesis and modeling, achieving flexible and precise arrangements of the microscopic units is challenging, which restricts the capabilities to fully understand and manipulate their polydomain-based properties. Here, we present a metastructure to mimic both mesoscale phase change and macroscopic mechanical properties of polydomain materials such as liquid crystal elastomers, which achieves unprecedented tunability over domain structures through the rational design of unit cells and their spatial arrangements. These metastructure system is used to explore and directly visualize the complex mesoscale topological deformation mechanisms hidden at molecular scales, providing fundamental insights into the mechanical properties of these materials. Beyond mimicking known polydomain materials, we demonstrate functionalities including mechanical encoding/decoding and programmable shape morphing. Our results establish a framework for understanding and designing topology-tunable functional polydomain materials.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz9811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Padlock-designed MOFs triggers an “avalanche effect” to enhance apoptosis and suppress metastasis in central nervous system lymphoma 挂锁设计的mof触发“雪崩效应”，以促进中枢神经系统淋巴瘤的细胞凋亡和抑制转移

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-03 DOI: 10.1126/sciadv.adv2647

Ying Gong, Zhongguo Zhou, Tianxing Xu, Fulin Liu, Anmei Chen, Liang Zou, Tao Jiang, Yi Shi, Yang-Bao Miao

{"title":"Padlock-designed MOFs triggers an “avalanche effect” to enhance apoptosis and suppress metastasis in central nervous system lymphoma","authors":"Ying Gong, Zhongguo Zhou, Tianxing Xu, Fulin Liu, Anmei Chen, Liang Zou, Tao Jiang, Yi Shi, Yang-Bao Miao","doi":"10.1126/sciadv.adv2647","DOIUrl":"10.1126/sciadv.adv2647","url":null,"abstract":"<div >The increasing incidence of central nervous system lymphoma (CNSL) is hindered by the blood-brain barrier and costly prolonged drug development. To overcome these obstacles, we developed a carboplatin lock-designed MOF (Pt-MOFs@Glu) targeting intestinal macrophages for brain-directed drug transport. Single-cell RNA sequencing analyses revealed that intestinal macrophages migrate to the brain in response to chemokines. Building on this insight, Pt-MOFs@Glu was designed to engage these cells for precise delivery. Comprising carboplatin, pyrazine-quinoxaline, and β-glucan, the system induces an “avalanche effect” in the CNSL microenvironment, promoting tumor apoptosis and inhibiting metastasis. Combining pyrazine-quinoxaline to lock carboplatin and β-glucan to boost targeting, immunity, and oral absorption, the system enables ROS-triggered drug release, efficiently crosses the gastrointestinal tract and BBB, and synergizes chemo-immunotherapy to enhance therapeutic efficacy. This approach redefines CNSL treatment by harnessing the gut-brain axis, offering a transformative pathway to overcoming therapeutic barriers and improving patient outcomes.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv2647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct measurement of Tan’s contact in a one-dimensional Lieb-Liniger gas 在一维利布-利尼格气体中直接测量Tan的接触

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-03 DOI: 10.1126/sciadv.adv3727

Qi Huang, Hepeng Yao, Xuzong Chen, Laurent Sanchez-Palencia

引用次数: 0

Relative sea level projections constrained by historical trends at tide gauge sites 潮汐测量站历史趋势约束下的相对海平面预测

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-01 DOI: 10.1126/sciadv.ado4506

Mahé Perrette, Matthias Mengel

{"title":"Relative sea level projections constrained by historical trends at tide gauge sites","authors":"Mahé Perrette, Matthias Mengel","doi":"10.1126/sciadv.ado4506","DOIUrl":"10.1126/sciadv.ado4506","url":null,"abstract":"<div >Assessing the impacts of future relative sea level rise requires projections consistent with historical observations. However, existing projections often do not align with past data, complicating adaptation planning, impact assessments, and communication. We present a spatial Bayesian model that generates local projections at tide gauge sites from historical records. The model integrates tide gauges, GPS, and satellite altimetry with past and future constraints on mountain glaciers, polar ice sheets, thermal expansion, ocean circulation, land water storage, and glacial history. By separating unforced ocean variability from long-term trends, we provide posterior estimates of sea level change and vertical land motion. The inclusion of local constraints reduces uncertainty in near-term local projections while producing global median projections and uncertainty ranges similar to those in the Sixth Assessment Report (AR6) of the Intergovernmental Panel on Climate Change (IPCC). The model enables projections of local relative sea level rise for any given global temperature trajectory, illustrated with three IPCC AR6 Working Group III pathways.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ado4506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual selection drives sex difference in adult life expectancy across mammals and birds 性选择导致哺乳动物和鸟类成年预期寿命的性别差异

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-01 DOI: 10.1126/sciadv.ady8433

Johanna Staerk, Dalia A. Conde, Morgane Tidière, Jean-François Lemaître, András Liker, Balázs Vági, Samuel Pavard, Mathieu Giraudeau, Simeon Q. Smeele, Orsolya Vincze, Victor Ronget, Rita da Silva, Zjef Pereboom, Mads F. Bertelsen, Jean-Michel Gaillard, Tamás Székely, Fernando Colchero

{"title":"Sexual selection drives sex difference in adult life expectancy across mammals and birds","authors":"Johanna Staerk, Dalia A. Conde, Morgane Tidière, Jean-François Lemaître, András Liker, Balázs Vági, Samuel Pavard, Mathieu Giraudeau, Simeon Q. Smeele, Orsolya Vincze, Victor Ronget, Rita da Silva, Zjef Pereboom, Mads F. Bertelsen, Jean-Michel Gaillard, Tamás Székely, Fernando Colchero","doi":"10.1126/sciadv.ady8433","DOIUrl":"10.1126/sciadv.ady8433","url":null,"abstract":"<div >Across human cultures and historical periods, women, on average, live longer than men, a pattern best understood from a comparative evolutionary perspective. Here, we analyzed adult life expectancy in 528 mammal and 648 bird species in zoos. Like humans, 72% of mammals exhibited a female life expectancy advantage, while 68% of birds showed a male advantage, as expected from the harmful effects of sex chromosomes described by the heterogametic sex hypothesis. Yet, sex differences varied widely. In zoos, we found strong evidence that this variation generally correlated with both the mating system and sexual size dimorphism. Although with weaker evidence, the patterns remained consistent in populations from the wild, with an even larger effect of the mating system. Thus, even in zoos, where environmental pressures are largely reduced, precopulatory sexual selection seems to play a fundamental role in shaping sex differences in life expectancy in mammals and birds.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady8433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0