Science Advances最新文献_第10页

Open or closed: pH modulation and calcification by foraminifera 开放或封闭：pH调节和有孔虫钙化

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-02 DOI: 10.1126/sciadv.adq8425

Daniel François, Gert-Jan Reichart, Lennart J. de Nooijer

{"title":"Open or closed: pH modulation and calcification by foraminifera","authors":"Daniel François, Gert-Jan Reichart, Lennart J. de Nooijer","doi":"10.1126/sciadv.adq8425","DOIUrl":"10.1126/sciadv.adq8425","url":null,"abstract":"<div >Marine calcifying organisms precipitate their shells either in equilibrium with seawater or under strict biological control. Here, we show that these two options represent two ends of a spectrum. In species with a more “closed” system, rates of H<sup>+</sup> removal and Ca<sup>2+</sup> uptake are high and exceed the amount of ions required for calcification. This explains the relatively low Mg/Ca of the calcite of this species by dilution of the [Mg<sup>2+</sup>] in the calcifying fluid. Conversely, in species with a more open system, the H<sup>+</sup> and Ca<sup>2+</sup> fluxes are lower, with more seawater exchanged between the environment and calcifying fluid, explaining the relatively high Mg/Ca in these foraminifera. In either of these species, mitochondria were found to be located at the site where the Ca<sup>2+</sup>/H<sup>+</sup> exchange takes place and the mitochondrial density aligned with the rate of pumping. These findings highlight the crucial role of transmembrane transporters and mitochondria in foraminifera calcification and explain the species-specific elemental signatures.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq8425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic evidence for behavioral adaptation of herding dogs 牧羊犬行为适应的基因组证据

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adp4591

Hankyeol Jeong, Elaine A. Ostrander, Jaemin Kim

{"title":"Genomic evidence for behavioral adaptation of herding dogs","authors":"Hankyeol Jeong, Elaine A. Ostrander, Jaemin Kim","doi":"10.1126/sciadv.adp4591","DOIUrl":"10.1126/sciadv.adp4591","url":null,"abstract":"<div >Herding dogs exhibit a distinct constellation of behaviors marked by inherent instinct and motor skills that manipulate and guide livestock in response to instructive commands and cues. Comparison of the whole-genome sequences of herding and nonherding breeds reveals signatures of positive selection associated with pathways underlying social interaction and cognitive functions. Of the strong selective sweep signals, haplotypes within ephrin type-B receptor 1 (<i>EPHB1</i>), which is linked to locomotor hyperactivity and spatial memory, show evidence of segregation within breed lineages for the conformation versus working lines of border collies and introgression with a genetically and geographically distant herding breed of Entlebucher mountain dogs. We show that a working line–specific haplotype of <i>EPHB1</i> is associated with elevated levels of chase-bite motor patterns based on a well-validated behavior survey. These findings indicate that functional selection has shaped the genetic architecture of herding breeds, which may relate to their proficiency in addressing diverse tasks and challenges in maintaining control over the herd.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp4591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes 克隆造血与不同的类风湿关节炎表型相关

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adt9846

Emil Hiitola, Juuso Korhonen, Heidi Kokkonen, Jukka Koskela, Matti Kankainen, Milla Alakuijala, Aoxing Liu, Sofie Lundgren, Paavo Häppölä, Henrikki Almusa, Pekka Ellonen, Paula Savola, Tiina Kelkka, Marjatta Leirisalo-Repo, Riitta Koivuniemi, Ritva Peltomaa, Laura Pirilä, Pia Isomäki, Markku Kauppi, Oili Kaipiainen-Seppänen, Inna Starskaia, Anniina T. Virtanen, Riitta Lahesmaa, Olli Silvennoinen, FinnGen, Giulio Genovese, Andrea Ganna, Solbritt Rantapää-Dahlqvist, Satu Mustjoki, Mikko Myllymäki

{"title":"Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes","authors":"Emil Hiitola, Juuso Korhonen, Heidi Kokkonen, Jukka Koskela, Matti Kankainen, Milla Alakuijala, Aoxing Liu, Sofie Lundgren, Paavo Häppölä, Henrikki Almusa, Pekka Ellonen, Paula Savola, Tiina Kelkka, Marjatta Leirisalo-Repo, Riitta Koivuniemi, Ritva Peltomaa, Laura Pirilä, Pia Isomäki, Markku Kauppi, Oili Kaipiainen-Seppänen, Inna Starskaia, Anniina T. Virtanen, Riitta Lahesmaa, Olli Silvennoinen, FinnGen, Giulio Genovese, Andrea Ganna, Solbritt Rantapää-Dahlqvist, Satu Mustjoki, Mikko Myllymäki","doi":"10.1126/sciadv.adt9846","DOIUrl":"10.1126/sciadv.adt9846","url":null,"abstract":"<div >Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation in nonmalignant conditions, its relationship with rheumatoid arthritis (RA) remains unknown. We analyzed CHIP mutations in RA using two population-level cohorts and patients with newly diagnosed RA. CHIP was associated with prevalent RA in 10,089 FINRISK study participants with whole-exome sequencing (OR, 2.06; <i>P</i> = 0.029) and in the FinnGen cohort (<i>n</i> = 520,210; OR, 1.49; <i>P</i> < 0.001) using single-nucleotide polymorphism array–based CHIP annotation. In FinnGen, CHIP was also associated with inferior overall survival in participants with RA (<i>P</i> = 0.013). In newly diagnosed RA (<i>n</i> = 573), <i>DNMT3A</i>-mutated seropositive patients had increased inflammatory markers and disease activity compared with patients without CHIP. In contrast, <i>TET2</i> mutations were enriched in seronegative RA (<i>P</i> = 0.009). Our findings provide further evidence for the context-dependent association between CHIP and inflammation, with potential therapeutic implications.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt9846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis 可吸入肌成纤维细胞靶向纳米颗粒协同治疗肺纤维化

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adv9571

Zhike Chen, Jian Yang, Qiang Zhang, Weibiao Zeng, Yi Liu, Wenxuan Hu, Linfu Chen, Jingjing Shen, Yu Miao, Zhisheng Xiao, Zhiqiang Wu, He Wang, Hui Shen, Cheng Ding, Qian Chen, Jun Zhao, Yang Yang

{"title":"Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis","authors":"Zhike Chen, Jian Yang, Qiang Zhang, Weibiao Zeng, Yi Liu, Wenxuan Hu, Linfu Chen, Jingjing Shen, Yu Miao, Zhisheng Xiao, Zhiqiang Wu, He Wang, Hui Shen, Cheng Ding, Qian Chen, Jun Zhao, Yang Yang","doi":"10.1126/sciadv.adv9571","DOIUrl":"10.1126/sciadv.adv9571","url":null,"abstract":"<div >Pulmonary fibrosis (PF) is a life-threatening interstitial lung disease, characterized by excessive fibroblast activation and collagen deposition, leading to progressive pulmonary function decline and limited therapeutic efficacy. Here, the inhalable, myofibroblast-targeted, and pH-responsive liposomes (FL-NI) were developed for effective codelivery of nintedanib, a mainstream antifibrotic drug in clinic, and siIL11, a small interfering RNA that silences the key profibrosis cytokine IL-11. Notably, FL-NI achieved a 117.8% increase in pulmonary drug delivery by noninvasive inhalation and a 71.5% increase in delivery specifically to fibroblast activation protein–positive myofibroblasts while reducing nonspecific immune cell and epithelial uptake by 29.8 and 55.8%, respectively. The accurate inhalation codelivery of nintedanib and siIL11 into myofibroblasts achieved synergistic effects, effectively enhanced myofibroblast deactivation, reduced pathological collagen deposition by 50.8%, and promoted epithelial tissue repair. FL-NI remodeled the aberrant immune microenvironment without inducing systemic toxicities. Therefore, this work demonstrated the notable potential for this pluripotent strategy for improving PF outcomes and its promising clinical translation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv9571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photonic quasicrystal of spin angular momentum 具有自旋角动量的光子准晶体

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adv3938

Min Lin, Xinxin Gou, Zhenwei Xie, Aiping Yang, Luping Du, Xiaocong Yuan

{"title":"Photonic quasicrystal of spin angular momentum","authors":"Min Lin, Xinxin Gou, Zhenwei Xie, Aiping Yang, Luping Du, Xiaocong Yuan","doi":"10.1126/sciadv.adv3938","DOIUrl":"10.1126/sciadv.adv3938","url":null,"abstract":"<div >Quasicrystals, characterized by long-range order without translational symmetry, have catalyzed transformative advances in various fields, including optics in terms of field quasicrystals. To our knowledge, we present the first demonstration of photonic quasicrystals formed by spin angular momentum, unveiling previously unidentified spin-orbit coupling effects absent in traditional field quasicrystals. A de Bruijn tiling like theoretical framework was built elucidating the formation mechanism of spin quasicrystals for diverse symmetries. Moreover, the configurations of these spin textures can be manipulated through the adjustments of the wavefronts, among which phason-like discontinuous dynamics is observed and quantitatively measured. Unlike optical quasicrystals shaped by electromagnetic fields, these spin-governed quasicrystals exhibit quasi-periodic properties of kinematic parameters, extending their potential applications to other physical systems. These findings hold promise for advancements in optical trapping, quasicrystal fabrication, and optical encryption systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv3938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultralow-pressure mechanical-motion switching of ferroelectric polarization 铁电极化的超低压机械运动开关

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adr5337

Baoyu Wang, Xin He, Jianjun Luo, Yitong Chen, Zhixiang Zhang, Ding Wang, Shangui Lan, Peijian Wang, Xun Han, Yuda Zhao, Zheng Li, Huan Hu, Yang Xu, Zhengdong Luo, Weijin Hu, Bowen Zhu, Jian Sun, Yan Liu, Genquan Han, Xixiang Zhang, Bin Yu, Kai Chang, Fei Xue

{"title":"Ultralow-pressure mechanical-motion switching of ferroelectric polarization","authors":"Baoyu Wang, Xin He, Jianjun Luo, Yitong Chen, Zhixiang Zhang, Ding Wang, Shangui Lan, Peijian Wang, Xun Han, Yuda Zhao, Zheng Li, Huan Hu, Yang Xu, Zhengdong Luo, Weijin Hu, Bowen Zhu, Jian Sun, Yan Liu, Genquan Han, Xixiang Zhang, Bin Yu, Kai Chang, Fei Xue","doi":"10.1126/sciadv.adr5337","DOIUrl":"10.1126/sciadv.adr5337","url":null,"abstract":"<div >Ferroelectric polarization switching, achieved by mechanical forces, enables the storage of stress information in ferroelectrics and holds promise for human interface applications. The prevailing mechanical approach is locally induced flexoelectricity with large strain gradients. However, this approach usually requires huge mechanical forces, which greatly impede device applications. Here, we report an approach of using triboelectric effect to mechanically, reversibly switch ferroelectric polarization across α-In<sub>2</sub>Se<sub>3</sub> ferroelectric memristors. Through contact electrification and electrostatic induction effects, triboelectric units are used to sensitively detect mechanical forces and generate electrical voltage pulses to trigger α-In<sub>2</sub>Se<sub>3</sub> resistance switching. We realize multilevel resistance states under different mechanical forces, by which a neuromorphic stress system is demonstrated. Notably, we achieve the reversal of α-In<sub>2</sub>Se<sub>3</sub> ferroelectric polarization with a record-low mechanical force of ~10 kilopascals and even with tactile touches. Our work provides a fundamental but pragmatic strategy for creating mechanical tactile ferroelectric memory devices.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr5337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triple cross-electrophile coupling enabled by palladium/norbornene cooperative catalysis 钯/降冰片烯协同催化实现三重交叉亲电偶联

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adu4573

Jinxiang Ye, Lifang Qi, Shuang Deng, Dandan Wang, Hengjiang Cong, Xiaotian Qi, Qianghui Zhou, Hong-Gang Cheng

{"title":"Triple cross-electrophile coupling enabled by palladium/norbornene cooperative catalysis","authors":"Jinxiang Ye, Lifang Qi, Shuang Deng, Dandan Wang, Hengjiang Cong, Xiaotian Qi, Qianghui Zhou, Hong-Gang Cheng","doi":"10.1126/sciadv.adu4573","DOIUrl":"10.1126/sciadv.adu4573","url":null,"abstract":"<div >Cross-electrophile coupling (XEC) is a powerful strategy for forming C–C bonds in synthetic organic chemistry. While XEC reactions between two electrophiles are well established, those involving three distinct electrophiles have remained underdeveloped. Herein, we report an intriguing formal triple XEC enabled by palladium/norbornene cooperative catalysis. Readily available aryl iodides, alkyl/aryl bromides, and propargyl esters are used as the distinct electrophilic coupling partners, leading to the synthesis of a diverse array of tetrasubstituted allenes. In particular, the challenging asymmetric formal triple XEC has also been realized through palladium/chiral norbornene cooperative catalysis, which uses the sterically hindered 2,6-disubstituted aryl bromides as the arylating reagents to prepare tetrasubstituted allenes bearing an axially chiral biaryl unit. Density functional theory calculations reveal that the selection of propargyl esters as electrophilic terminating reagents is key to the success of this reaction because it enables a thermodynamically favored pathway for reaction termination involving alkyne insertion followed by β-O elimination.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu4573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Brillouin photonics in thin-film lithium niobate 铌酸锂薄膜中的集成布里渊光子

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adv4022

Kaixuan Ye, Hanke Feng, Randy te Morsche, Chuangchuang Wei, Yvan Klaver, Akhileshwar Mishra, Zheng Zheng, Akshay Keloth, Ahmet Tarık Işık, Zhaoxi Chen, Cheng Wang, David Marpaung

{"title":"Integrated Brillouin photonics in thin-film lithium niobate","authors":"Kaixuan Ye, Hanke Feng, Randy te Morsche, Chuangchuang Wei, Yvan Klaver, Akhileshwar Mishra, Zheng Zheng, Akshay Keloth, Ahmet Tarık Işık, Zhaoxi Chen, Cheng Wang, David Marpaung","doi":"10.1126/sciadv.adv4022","DOIUrl":"10.1126/sciadv.adv4022","url":null,"abstract":"<div >Stimulated Brillouin scattering (SBS) is revolutionizing low-noise lasers and microwave photonics. However, a scalable and efficient integrated platform for Brillouin photonics has remained elusive. Here, we leverage the well-established thin-film lithium niobate (TFLN) platform to address these long-standing limitations. We report two distinct SBS processes on this platform, driven by surface acoustic wave (SAW) with 20-megahertz linewidth or bulk acoustic waves with a linewidth 200 times broader. Exploiting the strong SAW SBS gain, we demonstrate a narrowband internal net gain amplifier overcoming propagation losses. In addition, we achieve a stimulated Brillouin laser in TFLN, featuring a tuning range exceeding 20 nanometers and enabling high-purity radio frequency signal generation with an intrinsic linewidth of 9 hertz. Furthermore, we develop a programmable, multifunctional integrated Brillouin microwave photonic processor capable of notch filtering, bandpass filtering, or true time delay. This work bridges SBS with advanced TFLN technologies such as high-speed modulators and wideband optical frequency combs, unlocking new paradigms for integrated Brillouin photonics.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv4022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Massive experimental quantification allows interpretable deep learning of protein aggregation 大量的实验量化允许对蛋白质聚集进行可解释的深度学习

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adt5111

Mike Thompson, Mariano Martín, Trinidad Sanmartín Olmo, Chandana Rajesh, Peter K. Koo, Benedetta Bolognesi, Ben Lehner

引用次数: 0

Mortise-tenon–shaped memristors for scientific computing 科学计算用榫卯形忆阻器

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-30 DOI: 10.1126/sciadv.adu3309

Weiqi Dang, Yu Shen, Wei Wei, Chen Pan, Fanqiang Chen, Gong-Jie Ruan, Yan Luo, Ying Guo, Qiuyang Tan, Jingwen Shi, Xing-Jian Yangdong, Sicheng Chen, Cong Wang, Yongqin Xie, Zai-Zheng Yang, Pengfei Wang, Shuang Wang, Li Zhong, Shaobo Cheng, Chao Zhu, Bin Cheng, Shi-Jun Liang, Feng Miao

{"title":"Mortise-tenon–shaped memristors for scientific computing","authors":"Weiqi Dang, Yu Shen, Wei Wei, Chen Pan, Fanqiang Chen, Gong-Jie Ruan, Yan Luo, Ying Guo, Qiuyang Tan, Jingwen Shi, Xing-Jian Yangdong, Sicheng Chen, Cong Wang, Yongqin Xie, Zai-Zheng Yang, Pengfei Wang, Shuang Wang, Li Zhong, Shaobo Cheng, Chao Zhu, Bin Cheng, Shi-Jun Liang, Feng Miao","doi":"10.1126/sciadv.adu3309","DOIUrl":"10.1126/sciadv.adu3309","url":null,"abstract":"<div >In-memory computing hardware based on memristors has emerged as a promising option for scientific computing due to its large-scale parallel data processing capability. However, the nonuniformity issue of the memristors renders the practical deployment of in-memory computing hardware complex, requiring peripheral circuits to ensure the accuracy of scientific computing, thereby resulting in increased power consumption. Here, we present a mortise-tenon–shaped (MTS) memristor with ultrahigh uniformity by introducing a mortise-shaped h-BN flake on the HfO<sub>2</sub> switching layer. The MTS memristor exhibits ultrasmall cycle-to-cycle (~2.5%) and device-to-device (~6.9%) variations compared to the HfO<sub>2</sub> memristor without the MTS structure. Furthermore, we use the MTS memristors to build a partial differential equation solver and demonstrate a convergence speed of solving the Poisson equation five times faster than the solver based on the traditional HfO<sub>2</sub> memristors. This work provides a promising approach for notably reducing the hardware resources required for fast and high-accuracy scientific computing.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 18","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu3309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0