Science Advances最新文献_第10页

Blurring the lines between printed machines and living robots. 模糊了印刷机器和活生生的机器人之间的界限。

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 Epub Date: 2025-07-16 DOI: 10.1126/sciadv.aea2482

Robert K Katzschmann, Thomas J K Buchner

引用次数: 0

Acoustic technologies for the orchestration of cellular functions for therapeutic applications 用于细胞功能协调的声学技术

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adu4759

Ye He, Jianping Xia, John D. H. Mai, Neil Upreti, Luke P. Lee, Tony Jun Huang

{"title":"Acoustic technologies for the orchestration of cellular functions for therapeutic applications","authors":"Ye He, Jianping Xia, John D. H. Mai, Neil Upreti, Luke P. Lee, Tony Jun Huang","doi":"10.1126/sciadv.adu4759","DOIUrl":"10.1126/sciadv.adu4759","url":null,"abstract":"<div >Mechanical forces constantly stimulate cellular functions and influence their response behaviors. Similar to how an orchestra’s music synchronizes an audience, acoustic technologies have emerged as precise, contact-free tools to study cellular responses. These platforms generate forces at appropriate length and frequency scales, enabling precise interactions with cells. Recent advancements highlight their potential for regulating cellular functions, revealing both therapeutic promise and the need for further biochemical exploration. This review summarizes the progress in using acoustic technologies to orchestrate cellular functions in vitro through mechanical stimulation. We first introduce the main categories of acoustic platforms and their working principles in cellular research. Subsequently, we explore the fundamental mechanisms linking acoustics to specific cellular interactions. We then review recent applications of these technologies in precisely modulating cellular functions for therapeutic purposes. Last, we discuss strategies to enhance their performance and efficacy, along with their potential integration with other biomedical tools.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu4759","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Temporally programmed STING nanoadjuvant delivery unlocks synergistic chemotherapy-induced antitumor immunity 暂时编程的STING纳米佐剂递送解锁协同化疗诱导的抗肿瘤免疫

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adw0797

Zimeng Yang, Hengzhi Liu, Shuo Li, Zhaochu Xu, Wenxiao Li, Yubo Liu, Qingzhi Lv, Hongzhuo Liu, Zhonggui He, Yongjun Wang

{"title":"Temporally programmed STING nanoadjuvant delivery unlocks synergistic chemotherapy-induced antitumor immunity","authors":"Zimeng Yang, Hengzhi Liu, Shuo Li, Zhaochu Xu, Wenxiao Li, Yubo Liu, Qingzhi Lv, Hongzhuo Liu, Zhonggui He, Yongjun Wang","doi":"10.1126/sciadv.adw0797","DOIUrl":"10.1126/sciadv.adw0797","url":null,"abstract":"<div >Stimulator of interferon genes (STING) agonists have attracted notable attention for their potent immune activation capabilities. However, their clinical application is hindered by systemic toxicity and delivery inefficiencies. We addressed these challenges by developing a lymph node–targeted STING agonist nanoadjuvant (Mn/MSA-2@Lipo) combined with a temporally optimized delivery strategy. Mn/MSA-2@Lipo uses manganese ions to amplify STING pathway activation while achieving efficient lymph node accumulation and antigen presentation. We first induced immunogenic cell death (ICD) through chemotherapy to release tumor antigens, followed by the administration of the nanoadjuvant at an optimized time interval, the approach effectively synchronizes dendritic cell (DC) antigen uptake and maturation. This combination therapy notably enhanced antitumor immunity in melanoma and breast cancer models, achieving complete tumor regression and inducing long-lasting immune memory, all while demonstrating an excellent safety profile. Our findings highlight the critical importance of delivery timing optimization, offering a promising strategy for the clinical translation of STING agonists and the design of advanced immunotherapies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw0797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconfigurable high-dimensional synthetic photonic lattices 可重构高维合成光子晶格

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adw7198

Haiqi Huang, Zhuochen Du, Kun Liao, Xiaoyong Hu, Qihuang Gong

{"title":"Reconfigurable high-dimensional synthetic photonic lattices","authors":"Haiqi Huang, Zhuochen Du, Kun Liao, Xiaoyong Hu, Qihuang Gong","doi":"10.1126/sciadv.adw7198","DOIUrl":"10.1126/sciadv.adw7198","url":null,"abstract":"<div >Reconfigurable high-dimensional synthetic photonic lattices offer a promising platform for exploring the dynamic evolution of complex physical systems in high-dimensional spaces. However, the realization of reconfigurable high-dimensional synthetic lattices remains a notable challenge to date. Here, we propose a strategy for realizing dimensionally scalable temporal-domain synthetic photonic lattices, which enables independent control over both the phase and intensity of the signal light at each lattice site and time step within a high-dimensional space. By introducing multiple link rings to realize coupling between site rings, this strategy facilitates the exploration of a wide range of complex physical phenomena. We experimentally validate this proposed strategy in an optical fiber ring system, demonstrating nonreciprocal couplings up to three-dimensional space, topological funnel states, and periodic non-Hermitian temporal modulation to two-dimensional space. Moreover, we theoretically discuss the Weyl surfaces in five-dimensional space. This work provides a platform for exploring high-dimensional physics and paves the way for simulating complex systems, such as quantum many-body models.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A wearable device for continuous immunoassay-based monitoring of C-peptide in interstitial fluid 一种可穿戴设备，用于基于免疫分析的间质液中c肽的连续监测

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adw2182

Shengbo Chen, Ziyu Guo, Boxi Lu, Mengsi Sun, Saijie Wang, Shunhang Li, Yizhou Jiang, Qiwu Wei, Dou Wang, Xingyu Jiang

{"title":"A wearable device for continuous immunoassay-based monitoring of C-peptide in interstitial fluid","authors":"Shengbo Chen, Ziyu Guo, Boxi Lu, Mengsi Sun, Saijie Wang, Shunhang Li, Yizhou Jiang, Qiwu Wei, Dou Wang, Xingyu Jiang","doi":"10.1126/sciadv.adw2182","DOIUrl":"10.1126/sciadv.adw2182","url":null,"abstract":"<div >C-peptide is a critical biomarker for evaluating pancreatic β cell function and managing diabetes. However, conventional methods such as enzyme-linked immunosorbent assay are limited by lengthy processing times and the necessity for invasive sample collection. This study introduces a regenerable, portable, and wearable device for minimally invasive, real-time monitoring of C-peptide in dermal interstitial fluid (ISF). The device uses a microneedle array and negative pressure extraction for ISF collection. A double-antibody sandwich approach was used to detect C-peptide, and an antibody regeneration strategy was applied to remove bound antigen-antibody complexes, thereby achieving repeatable detection, enabling at least 10 detection assays on the same chip with negligible signal attenuation. The compact design features a skin contact area of only 3 cm by 5.4 cm and excellent biocompatibility. Integrated with a mobile app, the device provides real-time concentration reading. Mouse and rabbit tests confirm effective ISF sampling and monitoring accuracy, demonstrating its potential for at-home diabetes management and broader wearable biosensing applications.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw2182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Seismic imaging reveals a strain-partitioned sliver and nascent megathrust at an incipient subduction zone in the northeast Pacific 地震成像显示，在东北太平洋的一个早期俯冲带上，有一条应变分割的银条和新生的巨型逆冲构造

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adt3003

Collin C. Brandl, Lindsay L. Worthington, Emily C. Roland, Maureen A. L. Walton, Mladen R. Nedimović, Andrew C. Gase, Olumide Adedeji, Jose Castillo Castellanos, Benjamin J. Phrampus, Michael G. Bostock, Kelin Wang, Sarah Jaye Oliva

{"title":"Seismic imaging reveals a strain-partitioned sliver and nascent megathrust at an incipient subduction zone in the northeast Pacific","authors":"Collin C. Brandl, Lindsay L. Worthington, Emily C. Roland, Maureen A. L. Walton, Mladen R. Nedimović, Andrew C. Gase, Olumide Adedeji, Jose Castillo Castellanos, Benjamin J. Phrampus, Michael G. Bostock, Kelin Wang, Sarah Jaye Oliva","doi":"10.1126/sciadv.adt3003","DOIUrl":"10.1126/sciadv.adt3003","url":null,"abstract":"<div >The Queen Charlotte plate boundary (QCPB), a transform separating the Pacific and North American plates, accommodates ~55 millimeters per year of motion, is a source of large earthquakes in the northeast Pacific, and may be a modern site of subduction initiation. The southern QCPB experiences oblique convergence, showcased by the 1949 magnitude (<i>M</i>) 8.1 strike-slip earthquake and the 2012 <i>M</i>7.8 tsunamigenic thrust earthquake, both offshore Haida Gwaii, British Columbia. We present seismic reflection images of the southern QCPB, which constrain the crustal structure in unprecedented detail. The Queen Charlotte Terrace is underthrust by oceanic crust topped by a throughgoing, low-angle plate-boundary thrust, which ruptured in the 2012 earthquake. The Queen Charlotte Terrace is analogous to strain-partitioned, thin-skinned forearc slivers seen at oblique subduction zones, captured between a localized plate-boundary thrust and a mature strike-slip fault. Our imaging suggests that the system rapidly evolved from distributed to partitioned strain and is currently an incipient subduction zone.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt3003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Superstructural phase transitions in polymer-grafted nanooctahedra 聚合物接枝纳米八面体的超结构相变

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adw2740

Baixu Zhu, Jun Chen, Ruipeng Li, Jarett Ren, Yi Wang, Yaxu Zhong, Yang Liu, Akira Yasuhara, Mayu Kakefuda, Yoshitaka Aoyama, Thi Vo, Xingchen Ye

{"title":"Superstructural phase transitions in polymer-grafted nanooctahedra","authors":"Baixu Zhu, Jun Chen, Ruipeng Li, Jarett Ren, Yi Wang, Yaxu Zhong, Yang Liu, Akira Yasuhara, Mayu Kakefuda, Yoshitaka Aoyama, Thi Vo, Xingchen Ye","doi":"10.1126/sciadv.adw2740","DOIUrl":"10.1126/sciadv.adw2740","url":null,"abstract":"<div >Superlattices of polyhedral nanocrystals exhibit emergent properties defined by their structural arrangements, but native nanocrystal ligands often limit their programmability. Polymeric ligands address this limitation by enabling tunable nanocrystal softness through modifications of polymer molecular weight and grafting density. Here, we investigate phase transitions in polymer-grafted nanooctahedra by varying polymer length, nanocrystal size, truncation, and ligand density. In two-dimensional superlattices, longer polymers or smaller nanooctahedra induce a transition from orientationally ordered to hexagonal rotator lattices. In three-dimensional superlattices, increasing polymer length drives transitions from Minkowski to body-centered cubic and plastic hexagonal close-packed phases, while higher grafting densities further enable transitions to simple hexagonal phases. Polymer brush and thermodynamic perturbation theories, supported by Monte Carlo simulations, uncover the entropic and enthalpic forces that govern these transitions. This work highlights the versatility of polymer-grafted anisotropic nanocrystals as building blocks for designing hierarchical superstructures and metamaterials with customizable properties.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw2740","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement-induced photonic topological insulators 测量诱导光子拓扑绝缘体

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adx0595

Quancheng Liu, Weijie Liu, Yuechen Jia, Klaus Ziegler, Andrea Alù, Feng Chen

{"title":"Measurement-induced photonic topological insulators","authors":"Quancheng Liu, Weijie Liu, Yuechen Jia, Klaus Ziegler, Andrea Alù, Feng Chen","doi":"10.1126/sciadv.adx0595","DOIUrl":"10.1126/sciadv.adx0595","url":null,"abstract":"<div >Topological order in photonics, defined by pseudo-spin degrees of freedom, is traditionally static. By contrast, a unique quantum effect is that measurements alter system states. The convergence of these foundational concepts—measurement and topology—remains unexplored. Here, we demonstrate that topological order can be dynamically modified by repeated measurements. By fabricating a photonic lattice composed of an array of contiguous waveguides and incorporating 16,800 appended waveguide segments as discrete, nonindependent units, we established a classical-wave platform simulating the backaction from measurements and observed measurement-induced topological order in photonic lattices. Beyond topology, we further demonstrate that measurements can universally control the lattice by tailoring its Hilbert space and validate experimentally. Our study not only offers a quantum approach to dynamically tailor topological order but also unveils measurements as a powerful universal control tool, paving the way to on-chip topological materials and measurement-induced control over photonic systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx0595","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image-based inference of tumor cell trajectories enables large-scale cancer progression analysis 基于图像的肿瘤细胞轨迹推断使大规模的癌症进展分析成为可能

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adv9466

Yang Liu, Ling Cai, Ruichen Rong, Shidan Wang, Liwei Jia, Peiran Quan, Qin Zhou, Guanghua Xiao, Yang Xie

{"title":"Image-based inference of tumor cell trajectories enables large-scale cancer progression analysis","authors":"Yang Liu, Ling Cai, Ruichen Rong, Shidan Wang, Liwei Jia, Peiran Quan, Qin Zhou, Guanghua Xiao, Yang Xie","doi":"10.1126/sciadv.adv9466","DOIUrl":"10.1126/sciadv.adv9466","url":null,"abstract":"<div >Current approaches to estimating cell trajectories, tumor progression dynamics, and cell population diversity of tumor microenvironment often depend on single-cell RNA sequencing, which is costly and resource intensive. To address this limitation, we developed an artificial intelligence (AI) model that leverages cell morphology features and histological spatial organization to classify tumor cell differentiation status, infer cell dynamic trajectories, and quantify tumor progression from hematoxylin and eosin (H&E)–stained whole-slide images. In three independent lung adenocarcinoma cohorts, our AI-based model accurately predicted cell differential status and provided quantifiable measures of tumor progression that were prognostic of patient survival. Spatial transcriptomic integrative analyses revealed cell components and gene signatures enriched in different cell differentiation statuses. Bulk transcriptomic analyses revealed that fast-progressing tumors exhibit up-regulated cell cycle pathways, while slow-progressing tumors retain characteristics of normal lung epithelium. This cost-effective method enables large-scale analysis of tumor progression dynamics using routinely collected pathology slides and provides insights into intratumor heterogeneity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv9466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A shallow mantle source for the Chang’e 5 lavas reveals how top-down heating prolonged lunar magmatism 嫦娥五号熔岩的浅层地幔来源揭示了自上而下的加热是如何延长月球岩浆活动的

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adr1486

Stephen M. Elardo, Kim A. Cone, Matthew A. Siegler, Samuel J. Williams, Richard M. Palin

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