Science Advances最新文献

{"title":"Hepatic NMNAT1 is required to defend against alcohol-associated fatty liver disease.","authors":"Qinchao Ding, Feiwei Cao, Hui Zhuge, Shanglei Lai, Wenjing Cao, Haibin Wei, Rui Guo, Jiannan Qiu, Qing Song, Liuhua Pei, Chaolan Li, Caijuan Si, Zhaoli Sun, Zhenyuan Song, Xiaobing Dou, Songtao Li","doi":"10.1126/sciadv.adt6195","DOIUrl":"10.1126/sciadv.adt6195","url":null,"abstract":"<p><p>Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1), a nicotinamide adenine dinucleotide (NAD⁺) synthetase in Preiss-Handler and salvage pathways, governs nuclear NAD⁺ homeostasis. This study investigated the role of NMNAT1 in alcohol-associated liver disease (ALD). Decreased NMNAT1 expression and activity were observed in the liver of patients with alcohol-associated hepatitis and either liver or primary hepatocytes from ALD mice. F-box and WD repeat domain containing 7 (FBXW7)-regulated interferon regulatory factor 1 (IRF1) ubiquitination degradation contributed to the alcohol-inhibited NMNAT1 transcriptional level. Hepatic NMNAT1 knockout aggravated alcohol-induced hepatic NAD⁺ decline and further hepatic steatosis and liver injury. Metabolomics and transcriptomics interaction revealed that the cysteine sulfinic acid decarboxylase (CSAD)-regulated taurine pathway was involved in NMNAT1-disrupted hepatic lipid metabolism in ALD. Hepatic CSAD overexpression or taurine supply attenuated hepatic NMNAT1 knockout-aggravated ALD. Hepatic NMNAT1 loss inhibited NMN-protected ALD. Replenishing hepatic NMNAT1 reversed liver lipid accumulation in ALD mice. These findings identified NMNAT1 as a promising therapeutic target for ALD.</p>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":"eadt6195"},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micrometer-scale-thick quantum-dot LEDs with notably enhanced stability and ultrahigh brightness","authors":"Zinan Chen,&nbsp;Cuixia Yuan,&nbsp;Shuming Chen","doi":"","DOIUrl":"","url":null,"abstract":"<div >The thickness of quantum-dot light-emitting diodes (QLEDs) is typically limited to around 100 nm, which could lead to the formation of short-circuit paths that ultimately reduce the device performance. Here, we develop micrometer-scale-thick QLEDs by using extremely conductive ZnMgO as an electron transport layer. With a H₂O-regulated doping method, the electron concentration of the ZnMgO film is greatly increased, which results not only in the ohmic injection but also in the trap-free electron transport. As a result, micrometer-scale-thick QLEDs, with thickness of more than 10 times that of standard QLEDs, are achieved. The demonstrated micrometer-thick red QLEDs not only can be directly built on various substrates such as Cu slabs, Ag nanowire–coated substrate, Al foils, and printing papers but also can exhibit a notably enhanced <i>T</i>₉₀ life span over 11,000 hours at 1000 candelas per square meter and an ultrahigh brightness of 3,941,000 candelas per square meter, which represent 5.03- and 4.36-fold improvements over those of conventional QLEDs.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads7770","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed surfactants for stabilizing and controlling water transport in double emulsions","authors":"Eunseo Kim,&nbsp;Jongsun Yoon,&nbsp;Jong Dae Jang,&nbsp;Heemuk Oh,&nbsp;Hyomin Lee","doi":"","DOIUrl":"","url":null,"abstract":"<div >Double emulsions, comprising an aqueous droplet enclosed within an oil shell, hold great potential as versatile microcompartments for a variety of applications. However, their widespread utility is often limited by inherent instability and uncontrolled water transport. In this study, we use droplet microfluidics to prepare double emulsions with uniform thin oil shells stabilized by mixed surfactant systems. By combining monomeric and polymeric surfactants, we demonstrate that polymeric surfactants enhance stability by preventing oil shell drainage, while monomeric surfactants substantially increase water transport above a critical concentration, albeit reducing the emulsion lifespan. Swelling kinetics experiments, coupled with small-angle neutron scattering analysis, reveal that interface-controlled water transport occurs via mixed reverse micelle solubilization. This study provides valuable insights into designing double emulsions with optimized surfactant compositions, enabling enhanced stability and tunable water transport, with potential applications across food, cosmetics, and drug delivery systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv7043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered CD4 TCR T cells with conserved high-affinity TCRs targeting NY-ESO-1 for advanced cellular therapies in cancer","authors":"Margaux Saillard,&nbsp;Mara Cenerenti,&nbsp;Patrick Reichenbach,&nbsp;Philippe Guillaume,&nbsp;Ziyang Su,&nbsp;Morteza Hafezi,&nbsp;Julien Schmidt,&nbsp;Julien Cesbron,&nbsp;Raphaël Genolet,&nbsp;Lise Queiroz,&nbsp;Julien Racle,&nbsp;Jean Villard,&nbsp;Raffaele Renella,&nbsp;Olivier Michielin,&nbsp;Vincent Zoete,&nbsp;Jean-Paul Rivals,&nbsp;Melita Irving,&nbsp;Daniel E. Speiser,&nbsp;Alexandre Harari,&nbsp;David Gfeller,&nbsp;Olivier Adotevi,&nbsp;Francesco Ceppi,&nbsp;George Coukos,&nbsp;Pedro Romero,&nbsp;Camilla Jandus","doi":"","DOIUrl":"","url":null,"abstract":"<div >While cancer immunotherapy has primarily focused on CD8 T cells, CD4 T cells are increasingly recognized for their role in antitumor immunity. The <i>HLA-DRB3*02:02</i> allele is found in 50% of Caucasians. In this study, we screened <i>HLA-DRB3*02:02</i> patients with melanoma for tumor-specific CD4 T cells and identified robust New York esophageal squamous cell carcinoma 1 (NY-ESO-1)_123–137/<i>HLA-DRB3*02:02</i> CD4 T cell activity in both peripheral blood and tumor tissue. By analyzing NY-ESO-1_123–137/<i>HLA-DRB3*02:02</i>–restricted CD4 T cell clones, we uncovered an unexpectedly high cytotoxicity, strong T helper 1 polarization, and recurrent αβ T cell receptor (TCRαβ) usage across patients and anatomical sites. These responses were also present in other NY-ESO-1–expressing cancers. TCRs from these clones, when transduced into primary CD4 T cells, showed direct antitumor efficacy both in vitro and in vivo. Our findings suggest that these TCRs are promising for adoptive T cell transfer therapy, enabling broader targeting of NY-ESO-1–expressing adult and pediatric cancers in clinical settings.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu5754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase 2/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX/COVID-12 vaccine.","authors":"Constantino López-Macías, Martha Torres, Brenda Armenta-Copca, Niels H Wacher, Arturo Galindo-Fraga, Laura Castro-Castrezana, Andrea Alicia Colli-Domínguez, Edgar Cervantes-Trujano, Isabel Erika Rucker-Joerg, Fernando Lozano-Patiño, Juan José Rivera-Alcocer, Abraham Simón-Campos, Efrén Alberto Sánchez-Campos, Rafael Aguirre-Rivero, Alejandro José Muñiz-Carvajal, Luis Del Carpio-Orantes, Francisco Márquez-Díaz, Tania Rivera-Hernández, Alejandro Torres-Flores, Luis Ramírez-Martínez, Georgina Paz-De la Rosa, Oscar Rojas-Martínez, Alejandro Suárez-Martínez, Gustavo Peralta-Sánchez, Claudia Carranza, Esmeralda Juárez, Horacio Zamudio-Meza, Laura E Carreto-Binaghi, Mercedes Viettri, Damaris Romero-Rodríguez, Andrea Palencia, David Sarfati-Mizrahi, Weina Sun, Héctor Elías Chagoya-Cortés, Felipa Castro-Peralta, Peter Palese, Florian Krammer, Adolfo García-Sastre, Bernardo Lozano-Dubernard","doi":"10.1126/sciadv.adq2887","DOIUrl":"10.1126/sciadv.adq2887","url":null,"abstract":"<p><p>Low- and middle-income countries face substantial challenges in immunizing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including high costs, limited access, and insufficient local manufacturing. To address these issues, we developed and locally manufactured the AVX/COVID-12 vaccine using a cost-effective Newcastle disease virus LaSota platform to express a stabilized SARS-CoV-2 spike protein (HexaPro-S). We evaluated the AVX/COVID-12 vaccine in a phase 2/3 parallel-group, double-blind, active-controlled, noninferiority trial with 4056 volunteers, demonstrating its safety, good tolerability, and ability to induce neutralizing antibodies against ancestral SARS-CoV-2 and the Omicron BA.2 and BA.5 variants. It also stimulated interferon-γ-producing CD8⁺ T cells and met the World Health Organization's noninferiority criteria compared to AZ/ChAdOx-1-S. No vaccinated participants experienced severe disease, hospitalization, or death. These findings support the use of AVX/COVID-12 as a booster to help achieve and maintain population immunity while addressing global inequities in vaccine distribution, and it has been approved for adult booster use in Mexico.</p>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":"eadq2887"},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible multichannel muscle impedance sensors for collaborative human-machine interfaces","authors":"Junwei Li,&nbsp;Kunlin Wu,&nbsp;Jingcheng Xiao,&nbsp;Tianyu Chen,&nbsp;Xudong Yang,&nbsp;Jie Pan,&nbsp;Yu Chen,&nbsp;Yifan Wang","doi":"","DOIUrl":"","url":null,"abstract":"<div >The demand for advanced human-machine interfaces (HMIs) highlights the need for accurate measurement of muscle contraction states. Traditional methods, such as electromyography, cannot measure passive muscle contraction states, while optical and ultrasonic techniques suffer from motion artifacts due to their rigid transducers. To overcome these limitations, we developed a flexible multichannel electrical impedance sensor (FMEIS) for noninvasive detection of skeletal muscle contractions. By applying an imperceptible current, the FMEIS can target multiple deep muscles by capturing electric-field ripples generated by their contractions. With an ultrathin profile (~220 micrometers), a low elastic modulus (212.8 kilopascals) closely matching human skin, and engineered adhesive sensor surfaces, the FMEIS conforms nicely to human skin with minimized motion artifacts. The FMEIS achieved high accuracy in both hand gesture recognition and muscle force prediction using machine learning models. With demonstrated performance across multiple HMI applications, including human-robot collaboration, exoskeleton control, and virtual surgery, FMEIS shows great potential for future real-time collaborative HMI systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv3359","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anisotropic strain relaxation-induced directional ultrafast carrier dynamics in RuO2 films","authors":"Seung Gyo Jeong,&nbsp;In Hyeok Choi,&nbsp;Seungjun Lee,&nbsp;Jin Young Oh,&nbsp;Sreejith Nair,&nbsp;Jae Hyuck Lee,&nbsp;Changyoung Kim,&nbsp;Ambrose Seo,&nbsp;Woo Seok Choi,&nbsp;Tony Low,&nbsp;Jong Seok Lee,&nbsp;Bharat Jalan","doi":"","DOIUrl":"","url":null,"abstract":"<div >Ultrafast light-matter interactions inspire potential functionalities in picosecond optoelectronic applications. However, achieving directional carrier dynamics in metals remains challenging due to strong carrier scattering within a multiband environment, typically expected for isotropic carrier relaxation. In this study, we demonstrate epitaxial RuO₂/TiO₂ (110) heterostructures grown by hybrid molecular beam epitaxy to engineer polarization selectivity of ultrafast light-matter interactions via anisotropic strain engineering. Combining spectroscopic ellipsometry, x-ray absorption spectroscopy, and optical pump-probe spectroscopy, we revealed the strong anisotropic transient optoelectronic response at an excitation energy of 1.58 eV in strain-engineered RuO₂/TiO₂ (110) heterostructures along both in-plane [001] and [1<span><math><mstyle><mover><mn>1</mn><mo>¯</mo></mover></mstyle></math></span> 0] crystallographic directions. Theoretical analysis identifies strain-induced modifications in band nesting as the underlying mechanism for enhanced anisotropic carrier relaxation observed at this excitation energy. These findings establish epitaxial strain engineering as a powerful tool for tuning anisotropic optoelectronic responses with near-infrared excitations in metallic systems, paving the way for next-generation polarization-sensitive ultrafast optoelectronic devices.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantum sensing of broadband spin dynamics and magnon transport in antiferromagnets","authors":"Alex L. Melendez,&nbsp;Shekhar Das,&nbsp;Francisco Ayala Rodriguez,&nbsp;I-Hsuan Kao,&nbsp;Wenhao Liu,&nbsp;Archibald J. Williams,&nbsp;Bing Lv,&nbsp;Joshua Goldberger,&nbsp;Shubhayu Chatterjee,&nbsp;Simranjeet Singh,&nbsp;P. Chris Hammel","doi":"","DOIUrl":"","url":null,"abstract":"<div >Optical detection of magnetic resonance using quantum spin sensors (QSSs) provides a spatially local and sensitive technique to probe spin dynamics in magnets. However, its utility as a probe of antiferromagnetic resonance (AFMR) remains an open question. We report the experimental demonstration of optically detected AFMR in layered van der Waals antiferromagnets (AFM) up to frequencies of 24 gigahertz. We leverage QSS spin relaxation due to low-frequency magnetic field fluctuations arising from collective dynamics of magnons excited by the uniform AFMR mode. First, through AFMR spectroscopy, we characterize the intrinsic exchange fields and magnetic anisotropies of the AFM. Second, using the localized sensitivity of the QSS, we demonstrate magnon transport over tens of micrometers. Last, we find that optical detection efficiency increases with increasing frequency. This showcases the dual capabilities of QSS as detectors of high-frequency magnetization dynamics and magnon transport, paving the way for understanding and controlling the magnetism of antiferromagnets.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu9381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain relaxation in halide perovskites via 2D/3D perovskite heterojunction formation","authors":"Dongtao Liu,&nbsp;Jinxin Bi,&nbsp;Weidong Xu,&nbsp;Kieran W. P. Orr,&nbsp;Fei Wang,&nbsp;Xueping Liu,&nbsp;Aobo Ren,&nbsp;Jing Zhang,&nbsp;Steven Hinder,&nbsp;Bowei Li,&nbsp;Xiaoguang Luo,&nbsp;Yonglong Shen,&nbsp;Hanlin Hu,&nbsp;Guosheng Shao,&nbsp;Samuel D. Stranks,&nbsp;Lei Su,&nbsp;Wei Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<div >Applying mechanical strain and strain engineering to halide perovskites has endowed them with intriguing properties. However, an in-depth understanding of mechanical strain, including residual strain in halide perovskites, remains incomplete, coupled with the critical challenge of decoupling strain effects from other interferences. Here, we examine the relaxation of residual tensile strain in three-dimensional (3D) halide perovskites through 2D/3D perovskite heterojunction formation. The 2D perovskite induces structural fragmentation in 3D perovskites, facilitating plastic relaxation of tensile strain. By isolating extrinsic crystalline phase interference and exciton-related optical disturbances, we observe that 3D perovskites retain high crystallinity only with moderate tensile strain relaxation. This moderate relaxation enhances optoelectronic properties in 3D perovskites, including broadened band-to-band absorption and prolonged charge carrier lifetime, markedly contributing to an increase in the maximum attainable power conversion efficiency in photovoltaic devices. Our findings outline conditions for strain relaxation that optimize optoelectronic properties, advancing strain engineering in halide perovskites.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu3459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain relaxation in halide perovskites via 2D/3D perovskite heterojunction formation.","authors":"Dongtao Liu, Jinxin Bi, Weidong Xu, Kieran W P Orr, Fei Wang, Xueping Liu, Aobo Ren, Jing Zhang, Steven Hinder, Bowei Li, Xiaoguang Luo, Yonglong Shen, Hanlin Hu, Guosheng Shao, Samuel D Stranks, Lei Su, Wei Zhang","doi":"10.1126/sciadv.adu3459","DOIUrl":"10.1126/sciadv.adu3459","url":null,"abstract":"<p><p>Applying mechanical strain and strain engineering to halide perovskites has endowed them with intriguing properties. However, an in-depth understanding of mechanical strain, including residual strain in halide perovskites, remains incomplete, coupled with the critical challenge of decoupling strain effects from other interferences. Here, we examine the relaxation of residual tensile strain in three-dimensional (3D) halide perovskites through 2D/3D perovskite heterojunction formation. The 2D perovskite induces structural fragmentation in 3D perovskites, facilitating plastic relaxation of tensile strain. By isolating extrinsic crystalline phase interference and exciton-related optical disturbances, we observe that 3D perovskites retain high crystallinity only with moderate tensile strain relaxation. This moderate relaxation enhances optoelectronic properties in 3D perovskites, including broadened band-to-band absorption and prolonged charge carrier lifetime, markedly contributing to an increase in the maximum attainable power conversion efficiency in photovoltaic devices. Our findings outline conditions for strain relaxation that optimize optoelectronic properties, advancing strain engineering in halide perovskites.</p>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":"eadu3459"},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}