Science Advances最新文献_第9页

Live-cell quantification reveals viscoelastic regulation of synapsin condensates by α-synuclein 活细胞定量显示α-突触核蛋白对突触蛋白凝聚物的粘弹性调节

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.ads7627

Huan Wang, Christian Hoffmann, Johannes V. Tromm, Xiao Su, Jordan Elliott, Han Wang, Mengying Deng, Conor McClenaghan, Jean Baum, Zhiping P. Pang, Dragomir Milovanovic, Zheng Shi

{"title":"Live-cell quantification reveals viscoelastic regulation of synapsin condensates by α-synuclein","authors":"Huan Wang, Christian Hoffmann, Johannes V. Tromm, Xiao Su, Jordan Elliott, Han Wang, Mengying Deng, Conor McClenaghan, Jean Baum, Zhiping P. Pang, Dragomir Milovanovic, Zheng Shi","doi":"10.1126/sciadv.ads7627","DOIUrl":"10.1126/sciadv.ads7627","url":null,"abstract":"<div >Synapsin and α-synuclein represent a growing list of condensate-forming proteins where the material states of condensates are directly linked to cellular functions (e.g., neurotransmission) and pathology (e.g., neurodegeneration). However, quantifying condensate material properties in living systems has been a substantial challenge. Here, we develop micropipette aspiration and whole-cell patch-clamp (MAPAC), a platform that allows direct material quantification of condensates in live cells. We find 10,000-fold variations in the viscoelasticity of synapsin condensates, regulated by the partitioning of α-synuclein, a marker for synucleinopathies. Through in vitro reconstitutions, we identify multiple molecular factors that distinctly regulate the viscosity, interfacial tension, and maturation of synapsin condensates, confirming the cellular roles of α-synuclein. Overall, our study provides unprecedented quantitative insights into the material properties of neuronal condensates and reveals a crucial role of α-synuclein in regulating condensate viscoelasticity. Furthermore, we envision MAPAC applicable to study a broad range of condensates in vivo.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads7627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A METTL3-NFE2L3 axis mediates tumor stemness and progression in lung adenocarcinoma METTL3-NFE2L3轴介导肺腺癌的肿瘤干性和进展

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.adt7682

Yue Zhao, Lei Zhang, Lang Xia, Haoran E, Tao Wang, Huinan Lu, Hezhong Chen, Yunlang She, Hao Tang, Junqi Wu, Deping Zhao, Chang Chen

{"title":"A METTL3-NFE2L3 axis mediates tumor stemness and progression in lung adenocarcinoma","authors":"Yue Zhao, Lei Zhang, Lang Xia, Haoran E, Tao Wang, Huinan Lu, Hezhong Chen, Yunlang She, Hao Tang, Junqi Wu, Deping Zhao, Chang Chen","doi":"10.1126/sciadv.adt7682","DOIUrl":"10.1126/sciadv.adt7682","url":null,"abstract":"<div >The progression of lung adenocarcinoma is primarily driven by cancer stem cells (CSCs), which have self-renewal capabilities and confer resistance to therapies, including neoadjuvant treatments combining chemotherapy and immune checkpoint inhibitors. In this study, we identified that OV6<sup>+</sup> tumor cells exhibit stem-like characteristics and are notably enriched in patients with non–major pathological response, closely associated with resistance to combination therapies. Hypoxia and HIF1α were found to drive the formation of OV6<sup>+</sup> CSCs. METTL3, a methyltransferase, was revealed as a critical regulator of OV6<sup>+</sup> CSCs by stabilizing NFE2L3 messenger RNA via an <i>N</i><sup>6</sup>-methyladenosine–dependent manner, thereby up-regulating NFE2L3 and activating the intrinsic WNT signaling pathway essential for maintaining stemness. OV6<sup>+</sup> tumor cells promoted M2 macrophage infiltration and the formation of an immunosuppressive tumor microenvironment (TME). Targeting METTL3 effectively eliminated OV6<sup>+</sup> CSCs and suppressed tumor progression. Moreover, the combination of STM2457 with cisplatin overcame chemoresistance, remodeled the TME, and provided promising insights for enhancing the efficacy of neoadjuvant combination therapies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt7682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity 慢性BCR信号在衰老和自身免疫过程中无能B细胞向年龄相关B细胞分化中的关键作用

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.adt8199

Keisuke Imabayashi, Yutaro Yada, Kazuhiko Kawata, Motoki Yoshimura, Takeshi Iwasaki, Akemi Baba, Akihito Harada, Koichi Akashi, Hiroaki Niiro, Yoshihiro Baba

{"title":"Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity","authors":"Keisuke Imabayashi, Yutaro Yada, Kazuhiko Kawata, Motoki Yoshimura, Takeshi Iwasaki, Akemi Baba, Akihito Harada, Koichi Akashi, Hiroaki Niiro, Yoshihiro Baba","doi":"10.1126/sciadv.adt8199","DOIUrl":"10.1126/sciadv.adt8199","url":null,"abstract":"<div >Age-associated B cells (ABCs) with autoreactive properties accumulate with age and expand prematurely in autoimmune diseases. However, the mechanisms behind ABC generation and maintenance remain poorly understood. We show that continuous B cell receptor (BCR) signaling is essential for ABC development from anergic B cells in aged and autoimmune mice. ABCs exhibit constitutive BCR activation, with surface BCRs being internalized. Notably, anergic B cells, but not nonautoreactive B cells, contributed to ABC formation in these models. Anergic B cells also showed a greater propensity for in vitro differentiation into ABCs, which was inhibited by the expression of the transcription factor Nr4a1. Bruton’s tyrosine kinase (Btk), a key BCR signaling component, was constitutively activated in ABCs from aged and autoimmune mice as well as patients with lupus. Inhibiting Btk reduced ABC numbers and ameliorated the pathogenicity of lupus mice. Our findings reveal critical mechanisms underlying ABC development and offer previously unrecognized therapeutic insights for autoimmune diseases.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt8199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging 线粒体功能障碍引起的代谢重布线促进mtorc1依赖性骨骼衰老

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.ads1842

Kristina Bubb, Julia Etich, Kristina Probst, Tanvi Parashar, Maximilian Schuetter, Frederik Dethloff, Susanna Reincke, Janica L. Nolte, Marcus Krüger, Ursula Schlötzer-Schrehard, Julian Nüchel, Constantinos Demetriades, Patrick Giavalisco, Jan Riemer, Bent Brachvogel

{"title":"Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging","authors":"Kristina Bubb, Julia Etich, Kristina Probst, Tanvi Parashar, Maximilian Schuetter, Frederik Dethloff, Susanna Reincke, Janica L. Nolte, Marcus Krüger, Ursula Schlötzer-Schrehard, Julian Nüchel, Constantinos Demetriades, Patrick Giavalisco, Jan Riemer, Bent Brachvogel","doi":"10.1126/sciadv.ads1842","DOIUrl":"10.1126/sciadv.ads1842","url":null,"abstract":"<div >Decline of mitochondrial respiratory chain (mtRC) capacity is a hallmark of mitochondrial diseases. Patients with mtRC dysfunction often present reduced skeletal growth as a sign of premature cartilage degeneration and aging, but how metabolic adaptations contribute to this phenotype is poorly understood. Here we show that, in mice with impaired mtRC in cartilage, reductive/reverse TCA cycle segments are activated to produce metabolite-derived amino acids and stimulate biosynthesis processes by mechanistic target of rapamycin complex 1 (mTORC1) activation during a period of massive skeletal growth and biomass production. However, chronic hyperactivation of mTORC1 suppresses autophagy-mediated organelle recycling and disturbs extracellular matrix secretion to trigger chondrocytes death, which is ameliorated by targeting the reductive metabolism. These findings explain how a primarily beneficial metabolic adaptation response required to counterbalance the loss of mtRC function, eventually translates into profound cell death and cartilage tissue degeneration. The knowledge of these dysregulated key nutrient signaling pathways can be used to target skeletal aging in mitochondrial disease.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads1842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cocrystals combining order and correlated disorder via colloidal crystal engineering with DNA 利用DNA胶体晶体工程实现有序和相关无序的共晶结合

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.adu4919

Yuanwei Li, Wenjie Zhou, Yuan Zhou, Ho Fung Cheng, Byeongdu Lee, Xiaobing Hu, Eric W. Roth, Vinayak P. Dravid, Sharon C. Glotzer, Chad A. Mirkin

{"title":"Cocrystals combining order and correlated disorder via colloidal crystal engineering with DNA","authors":"Yuanwei Li, Wenjie Zhou, Yuan Zhou, Ho Fung Cheng, Byeongdu Lee, Xiaobing Hu, Eric W. Roth, Vinayak P. Dravid, Sharon C. Glotzer, Chad A. Mirkin","doi":"10.1126/sciadv.adu4919","DOIUrl":"10.1126/sciadv.adu4919","url":null,"abstract":"<div >Colloidal cocrystallization enables the formation of multicomponent materials with unique physicochemical properties, yet the role of nanoparticle (NP) shape and specific ligand interactions to cocrystallize anisotropic and isotropic NPs, with order and correlated disorder, remains underexplored. Here, geometry-inspired strategies along with programmable DNA interactions are combined to achieve structural control of colloidal cocrystal assemblies. Coassembling polyhedral and spherical NPs with complementary DNA yields two classes of cocrystals: one where both components order, and another where polyhedral NPs form a periodic lattice, while spherical NPs remain disordered but spatially correlated with polyhedral edges and corners. The size ratio of the building blocks can be used to control the ordering of spherical NPs—smaller octahedral-to-sphere size ratios favor fully ordered cocrystals. Molecular dynamics simulations further elucidate the role of NP shapes and dimensions in the structural outcome of the cocrystal. This work provides a framework for deliberately targeting and accessing crystals with exotic multicomponent structures.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu4919","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local suppression by link rewiring reveals discontinuous percolation transitions 链路重新布线的局部抑制揭示了不连续的渗透过渡

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.adt0355

Young Sul Cho

引用次数: 0

Inefficient melt mixing below a fast-spreading ridge revealed by Hess Deep lower gabbros (ODP Leg 147 and IODP Expedition 345) 在赫斯深下辉长岩显示的快速扩张脊下的低效熔体混合（ODP第147号和IODP第345次考察）

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.adu2044

Valentin Basch, Alessio Sanfilippo, Felix Genske, Mischa Böhnke, Alberto Zanetti, Andreas Stracke

{"title":"Inefficient melt mixing below a fast-spreading ridge revealed by Hess Deep lower gabbros (ODP Leg 147 and IODP Expedition 345)","authors":"Valentin Basch, Alessio Sanfilippo, Felix Genske, Mischa Böhnke, Alberto Zanetti, Andreas Stracke","doi":"10.1126/sciadv.adu2044","DOIUrl":"10.1126/sciadv.adu2044","url":null,"abstract":"<div >The oceanic crust crystallizes from melts formed within a heterogeneous mantle source, which is mostly composed of variably depleted peridotites and recycled crust. Yet, the compositional variability of this mantle source and the progressive aggregation of heterogeneous melts during extraction are poorly constrained. Here, we show that in situ isotopic analyses in gabbros formed at the East Pacific Rise retain substantially greater Sr-Nd-Hf isotopic heterogeneity than basalts erupted along the fast-spreading ridge. This implies that melt aggregation during migration through the upper mantle and lower crust is inefficient, even at magmatically productive spreading ridges; efficient melt mixing likely occurs in the overlying axial melt lens. Local isotopic heterogeneity of Hess Deep gabbros indicates incomplete mixing of primary melts produced from variably depleted peridotites and oceanic crust recycled at least 1.5 billion years ago. The isotopic heterogeneity recorded in lower gabbros further substantiates that basalt compositions reflect only part of the compositional spectrum of melts passing through the ridge plumbing system.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu2044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoprene deters insect herbivory by priming plant hormone responses 异戊二烯通过引发植物激素反应来阻止昆虫的食草性

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.adu4637

Abira Sahu, Mohammad Golam Mostofa, Yuan Xu, Bianca M. Serda, James O’Keefe, Thomas D. Sharkey

{"title":"Isoprene deters insect herbivory by priming plant hormone responses","authors":"Abira Sahu, Mohammad Golam Mostofa, Yuan Xu, Bianca M. Serda, James O’Keefe, Thomas D. Sharkey","doi":"10.1126/sciadv.adu4637","DOIUrl":"10.1126/sciadv.adu4637","url":null,"abstract":"<div >Isoprene, emitted by some plants, deters insect herbivory. However, the associated biochemical and physiological responses that confer herbivory resistance remain unknown. We used engineered isoprene-emitting (IE) and non-emitting (NE) control tobacco plants to interpret isoprene-mediated defense against herbivory in plants. Hornworm larvae raised on IE plants exhibited stunted growth compared to those raised on NE plants. Worms preferred to feed on NE rather than IE leaves, indicating deterrent effects of isoprene on insect feeding. Worm feeding induced a greater increase in jasmonic acid (JA), a crucial hormone for insect resistance, in IE leaves compared to that in NE leaves. Assimilation rates were stably maintained in IE plants, suggesting a protective role of isoprene in preserving photosynthetic efficiency during insect herbivory. Wound-induced increase in isoprene emission correlated with the elevation of key metabolites of the isoprene biosynthesis pathway. Our results highlight JA-priming functions of isoprene and provide insights into isoprene-mediated defense against insect herbivory.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu4637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustained mTORC1 activation in activated T cells impairs vaccine responses in older individuals 激活T细胞中mTORC1的持续激活会损害老年人的疫苗应答

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.adt4881

Xiaorong Lin, Yanhua Du, Shuo Kan, Junjie Chen, Yunxue Yin, Linlin Li, Jingwen Chen, Wenrong Jiang, Wenqiang Cao, Chulwoo Kim, Liang Chen, Shiwen Wang, Jorg J. Goronzy, Jun Jin

{"title":"Sustained mTORC1 activation in activated T cells impairs vaccine responses in older individuals","authors":"Xiaorong Lin, Yanhua Du, Shuo Kan, Junjie Chen, Yunxue Yin, Linlin Li, Jingwen Chen, Wenrong Jiang, Wenqiang Cao, Chulwoo Kim, Liang Chen, Shiwen Wang, Jorg J. Goronzy, Jun Jin","doi":"10.1126/sciadv.adt4881","DOIUrl":"10.1126/sciadv.adt4881","url":null,"abstract":"<div >T cell aging contributes to the lower vaccine efficacy in older adults, yet the molecular mechanism remains elusive. Here, we show the density of initially responding naïve CD4<sup>+</sup> T cells is instructive in T follicular helper (TFH) cell fate decisions and declines with age. A lower number of initially responding cells did not affect TFH differentiation at peak responses after immunization but accounted for an increased contraction phase manifesting as a larger loss of CXCR5 expression. Mechanistically, cells activated at a lower initial density had more sustained mammalian target of rapamycin complex 1 (mTORC1) activities that impair CXCR5 maintenance. YAP-dependent regulation of SLC7A5 involved in the cell density–dependent regulation of mTORC1 activities and TFH loss. Old mice fed with a leucine-restricted diet after peak responses showed smaller TFH loss and improved humoral immune responses. Attenuating mTORC1 signaling after peak response is a strategy to boost vaccine responses in older individuals.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt4881","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress 线粒体基因表达的空间分析揭示了胁迫下的动态翻译中心和重塑

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-04-18 DOI: 10.1126/sciadv.ads6830

Adam Begeman, John A. Smolka, Ahmad Shami, Tejashree Pradip Waingankar, Samantha C. Lewis

{"title":"Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress","authors":"Adam Begeman, John A. Smolka, Ahmad Shami, Tejashree Pradip Waingankar, Samantha C. Lewis","doi":"10.1126/sciadv.ads6830","DOIUrl":"10.1126/sciadv.ads6830","url":null,"abstract":"<div >Protein- and RNA-rich bodies contribute to the spatial organization of gene expression in the cell and are also sites of quality control critical to cell fitness. In most eukaryotes, mitochondria harbor their own genome, and all steps of mitochondrial gene expression co-occur within a single compartment—the matrix. Here, we report that processed mitochondrial RNAs are consolidated into micrometer-scale translation hubs distal to mitochondrial DNA transcription and RNA processing sites in human cells. We find that, during stress, mitochondrial messenger and ribosomal RNA are sequestered in mesoscale bodies containing mitoribosome components, concurrent with suppression of active translation. Stress bodies are triggered by proteotoxic stress downstream of double-stranded RNA accumulation in cells lacking unwinding activity of the highly conserved helicase SUPV3L1/SUV3. We propose that the spatial organization of nascent polypeptide synthesis into discrete domains serves to throttle the flow of genetic information to support recovery of mitochondrial quality control.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 16","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads6830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0