Science Advances最新文献_第9页

Mitochondrial elongation impairs breast cancer metastasis 线粒体伸长阻碍乳腺癌转移

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adm8212

Lucía Minarrieta, Matthew G. Annis, Yannick Audet-Delage, Hellen Kuasne, Alain Pacis, Catherine St-Louis, Alexander Nowakowski, Marco Biondini, Mireille Khacho, Morag Park, Peter M. Siegel, Julie St-Pierre

{"title":"Mitochondrial elongation impairs breast cancer metastasis","authors":"Lucía Minarrieta, Matthew G. Annis, Yannick Audet-Delage, Hellen Kuasne, Alain Pacis, Catherine St-Louis, Alexander Nowakowski, Marco Biondini, Mireille Khacho, Morag Park, Peter M. Siegel, Julie St-Pierre","doi":"10.1126/sciadv.adm8212","DOIUrl":"10.1126/sciadv.adm8212","url":null,"abstract":"<div >Mitochondrial dynamics orchestrate many essential cellular functions, including metabolism, which is instrumental in promoting cancer growth and metastatic progression. However, how mitochondrial dynamics influences metastatic progression remains poorly understood. Here, we show that breast cancer cells with low metastatic potential exhibit a more fused mitochondrial network compared to highly metastatic cells. To study the impact of mitochondrial dynamics on metastasis, we promoted mitochondrial elongation in metastatic breast cancer cells by individual genetic deletion of three key regulators of mitochondrial fission (Drp1, Fis1, Mff) or by pharmacological intervention with leflunomide. Omics analyses revealed that mitochondrial elongation causes substantial alterations in metabolic pathways and processes related to cell adhesion. In vivo, enhanced mitochondrial elongation by loss of mitochondrial fission mediators or treatment with leflunomide notably reduced metastasis formation. Furthermore, the transcriptomic signature associated with elongated mitochondria correlated with improved clinical outcome in patients with breast cancer. Overall, our findings highlight mitochondrial dynamics as a potential therapeutic target in breast cancer.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adm8212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Inability to pursue nonrigid motion produces instability of spatial perception 无法追求非刚性运动会导致空间感知不稳定

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adp6204

Krischan Koerfer, Tamara Watson, Markus Lappe

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Luck, skill, and depth of competition in games and social hierarchies 游戏和社会等级中的运气、技能和竞争深度

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adn2654

Maximilian Jerdee, M. E. J. Newman

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Anthropogenic warming has ushered in an era of temperature-dominated droughts in the western United States 人类活动导致的气候变暖使美国西部进入了以气温为主的干旱时代

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adn9389

Yizhou Zhuang, Rong Fu, Joel Lisonbee, Amanda M. Sheffield, Britt A. Parker, Genoveva Deheza

{"title":"Anthropogenic warming has ushered in an era of temperature-dominated droughts in the western United States","authors":"Yizhou Zhuang, Rong Fu, Joel Lisonbee, Amanda M. Sheffield, Britt A. Parker, Genoveva Deheza","doi":"10.1126/sciadv.adn9389","DOIUrl":"10.1126/sciadv.adn9389","url":null,"abstract":"<div >Historically, meteorological drought in the western United States (WUS) has been driven primarily by precipitation deficits. However, our observational analysis shows that, since around 2000, rising surface temperature and the resulting high evaporative demand have contributed more to drought severity (62%) and coverage (66%) over the WUS than precipitation deficit. This increase in evaporative demand during droughts, mostly attributable to anthropogenic warming according to analyses of both observations and climate model simulations, is the main cause of the increased drought severity and coverage. The unprecedented 2020–2022 WUS drought exemplifies this shift in drought drivers, with high evaporative demand accounting for 61% of its severity, compared to 39% from precipitation deficit. Climate model simulations corroborate this shift and project that, under the fossil-fueled development scenario (SSP5-8.5), droughts like the 2020–2022 event will transition from a one-in-more-than-a-thousand-year event in the pre-2022 period to a 1-in-60-year event by the mid-21st century and to a 1-in-6-year event by the late-21st century.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adn9389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptic-like plasticity in 2D nanofluidic memristor from competitive bicationic transport 二维纳米流体忆阻器中类似突触的可塑性来自竞争性双向传输

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adr1531

Yechan Noh, Alex Smolyanitsky

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Single-step synthesis of shaped polymeric particles using initiated chemical vapor deposition in liquid crystals 利用液晶中的引发化学气相沉积技术一步合成异形聚合物颗粒

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adp5573

Apoorva Jain, Soumyamouli Pal, Shiqi Li, Nicholas L. Abbott, Rong Yang

{"title":"Single-step synthesis of shaped polymeric particles using initiated chemical vapor deposition in liquid crystals","authors":"Apoorva Jain, Soumyamouli Pal, Shiqi Li, Nicholas L. Abbott, Rong Yang","doi":"10.1126/sciadv.adp5573","DOIUrl":"10.1126/sciadv.adp5573","url":null,"abstract":"<div >We elucidate a previously unknown synthesis pathway that leads to polymeric nanospheres, orientation-controlled microgels, or microspheroids via single-step polymerization of divinylbenzene (DVB) using initiated chemical vapor deposition (iCVD) in liquid crystals (LC). iCVD supplies vapor-phase reactants continuously, avoiding the critical limitation of reactant-induced disruption of LC structure that has plagued past LC-templated polymerization processes. LC is leveraged as a real-time display of the polymerization conditions and particle emergence, captured using an in situ long–focal range microscope. Detailed image analysis unravels key LC-guided mechanisms during polymerization. pDVB forms nanospheres due to poor solubilization by nematic LC. The nanospheres partition to the LC-solid interface and further assemble into microgel clusters whose orientation is guided by the LC molecular alignment. On further polymerization, microgel clusters transition to microspheroids that resemble liquid drops. We identify key energetic factors that guide trajectories along the synthesis pathway, providing the fundamental basis of a framework for engineering particle synthesis with shape control.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp5573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A normative framework dissociates need and motivation in hypothalamic neurons 规范框架将下丘脑神经元中的需求和动机区分开来

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.ado1820

Kyu Sik Kim, Young Hee Lee, Jong Won Yun, Yu-Been Kim, Ha Young Song, Joon Seok Park, Sang-Ho Jung, Jong-Woo Sohn, Ki Woo Kim, HyungGoo R. Kim, Hyung Jin Choi

{"title":"A normative framework dissociates need and motivation in hypothalamic neurons","authors":"Kyu Sik Kim, Young Hee Lee, Jong Won Yun, Yu-Been Kim, Ha Young Song, Joon Seok Park, Sang-Ho Jung, Jong-Woo Sohn, Ki Woo Kim, HyungGoo R. Kim, Hyung Jin Choi","doi":"10.1126/sciadv.ado1820","DOIUrl":"10.1126/sciadv.ado1820","url":null,"abstract":"<div >Physiological needs evoke motivational drives that produce natural behaviors for survival. In previous studies, the temporally intertwined dynamics of need and motivation have made it challenging to differentiate these two components. On the basis of classic homeostatic theories, we established a normative framework to derive computational models for need-encoding and motivation-encoding neurons. By combining the model-based predictions and naturalistic experimental paradigms, we demonstrated that agouti-related peptide (AgRP) and lateral hypothalamic leptin receptor (LH<sup>LepR)</sup> neuronal activities encode need and motivation, respectively. Our model further explains the difference in the dynamics of appetitive behaviors induced by optogenetic stimulation of AgRP or LH<sup>LepR</sup> neurons. Our study provides a normative modeling framework that explains how hypothalamic neurons separately encode need and motivation in the mammalian brain.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ado1820","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Comparing Shor and Steane error correction using the Bacon-Shor code 使用培根-肖尔代码比较肖尔和斯泰恩纠错法

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adp2008

Shilin Huang, Kenneth R. Brown, Marko Cetina

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Ocean weather systems on icy moons, with application to Enceladus 冰卫星上的海洋天气系统，并应用于土卫二

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adn6857

Yixiao Zhang, Wanying Kang, John Marshall

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Tailored ultrasound propagation in microscale metamaterials via inertia design 通过惯性设计实现微尺度超材料中的定制超声波传播

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-06 DOI: 10.1126/sciadv.adq6425

Rachel Sun, Jet Lem, Yun Kai, Washington DeLima, Carlos M. Portela

{"title":"Tailored ultrasound propagation in microscale metamaterials via inertia design","authors":"Rachel Sun, Jet Lem, Yun Kai, Washington DeLima, Carlos M. Portela","doi":"10.1126/sciadv.adq6425","DOIUrl":"10.1126/sciadv.adq6425","url":null,"abstract":"<div >The quasi-static properties of micro-architected (meta)materials have been extensively studied over the past decade, but their dynamic responses, especially in acoustic metamaterials with engineered wave propagation behavior, represent a new frontier. However, challenges in miniaturizing and characterizing acoustic metamaterials in high-frequency (megahertz) regimes have hindered progress toward experimentally implementing ultrasonic-wave control. Here, we present an inertia design framework based on positioning microspheres to tune responses of 3D microscale metamaterials. We demonstrate tunable quasi-static stiffness by up to 75% and dynamic longitudinal-wave velocities by up to 25% while maintaining identical material density. Using noncontact laser-based dynamic experiments of tunable elastodynamic properties and numerical demonstrations of spatio-temporal ultrasound wave propagation, we explore the tunable static and elastodynamic property relation. This design framework expands the quasi-static and dynamic metamaterial property space through simple geometric changes, enabling facile design and fabrication of metamaterials for applications in medical ultrasound and analog computing.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq6425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0