Science Advances最新文献_第9页

Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones 衰老干细胞群的多组学鉴定对软骨下骨关节炎的进展和治疗至关重要

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adu2294

Pei Lin Li, Jie Tang, Xiao Tong Li, Shi Rong Zhao, Run Xiang Xu, Zhi Dong Zhao, Zhong Li Li, Zhi Ling Li, Bo Feng Yin, Fu Hao Yu, Chu Tse Wu, Heng Zhu

{"title":"Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones","authors":"Pei Lin Li, Jie Tang, Xiao Tong Li, Shi Rong Zhao, Run Xiang Xu, Zhi Dong Zhao, Zhong Li Li, Zhi Ling Li, Bo Feng Yin, Fu Hao Yu, Chu Tse Wu, Heng Zhu","doi":"10.1126/sciadv.adu2294","DOIUrl":"10.1126/sciadv.adu2294","url":null,"abstract":"<div >Osteoarthritis (OA) is a challenging degenerative joint disease with limited treatment options. Subchondral bone plays a critical role in maintaining joint homeostasis and influencing OA progression. Here, we investigated the role of senescence in mesenchyme-derived stem/progenitor cells (MDSPCs) during OA progression, aiming to identify potential therapeutic targets. Histopathological evaluations and bioinformatic analyses of OA samples from both humans and mice revealed that EGFR<sup>+</sup> MDSPCs and EREG<sup>+</sup> macrophages constitute a senescent skeletal unit within the osteoarthritic articular subchondral bone. In vitro and in vivo experiments demonstrated that EREG promotes senescence and excessive osteogenesis in EGFR<sup>+</sup> MDSPCs. Moreover, interference with <i>Ereg</i> expression, via adeno-associated virus–mediated <i>Ereg</i> knockdown or genetic knockout in mice, significantly suppressed senescence of EGFR<sup>+</sup> MDSPCs in subchondral bone and alleviated both pathological sclerosis and pain in OA mice. Our findings indicate that MDSPC senescence in the subchondral bone is a key event driving OA progression, offering a valuable reference point to develop innovative therapeutic strategies for OA.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu2294","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology 内源性逆转录病毒样蛋白招募UBQLN2来胁迫颗粒并塑造其功能生物学

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adu6354

Harihar M. Mohan, Martin G. Fernandez, Camellia Huang, Rita Lin, Jaimie H. Ryou, Donald Seyfried, Nikolas Grotewold, Anna J. Barget, Alexandra M. Whiteley, Venkatesha Basrur, Shyamal Mosalaganti, Henry L. Paulson, Lisa M. Sharkey

{"title":"Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology","authors":"Harihar M. Mohan, Martin G. Fernandez, Camellia Huang, Rita Lin, Jaimie H. Ryou, Donald Seyfried, Nikolas Grotewold, Anna J. Barget, Alexandra M. Whiteley, Venkatesha Basrur, Shyamal Mosalaganti, Henry L. Paulson, Lisa M. Sharkey","doi":"10.1126/sciadv.adu6354","DOIUrl":"10.1126/sciadv.adu6354","url":null,"abstract":"<div >The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. Here, we show that UBQLN2, a ubiquitin-proteasome shuttle factor implicated in neurodegenerative diseases, is regulated by the linked actions of two retrovirus-like proteins, retrotransposon gag-like 8 (RTL8) and paternally expressed gene 10 (PEG10). RTL8 confers on UBQLN2 the ability to complex with and regulate PEG10. PEG10, a core component of stress granules, drives the recruitment of UBQLN2 to stress granules under various stress conditions but can only do so when RTL8 is present. Changes in UBQLN2, RTL8, or PEG10 levels further remodel the kinetics of stress granule disassembly and translation recovery. PEG10 also alters overall stress granule composition by incorporating select extracellular vesicle proteins. Within stress granules, PEG10 forms virus-like particles, underscoring the structural heterogeneity of this class of biomolecular condensates. Together, these results reveal an unexpected link between pathways of cellular proteostasis and endogenous retrovirus-like proteins.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu6354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Architecture mechanics mediated osteogenic progression in bone regeneration of artificial scaffolds 建筑力学介导人工支架骨再生的成骨进程

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adv8804

Si-Yu Long, Ya-Jun Fu, Zheng-Min Zhang, Rui Tang, Peng Yu, Wei Yang

{"title":"Architecture mechanics mediated osteogenic progression in bone regeneration of artificial scaffolds","authors":"Si-Yu Long, Ya-Jun Fu, Zheng-Min Zhang, Rui Tang, Peng Yu, Wei Yang","doi":"10.1126/sciadv.adv8804","DOIUrl":"10.1126/sciadv.adv8804","url":null,"abstract":"<div >Scaffold architecture exerts a considerable influence on the osteogenic effect through stress transmission, as the deformation of scaffolds alters the mechanical microenvironment of cells adhering to scaffold surface. Despite extensive research on bone regeneration influenced by scaffold architecture, present studies have not addressed the biological mechanism underlying scaffold architecture-induced stress stimulation (SASS) on cells yet, posing a great challenge in revealing the biomechanical cues between scaffold architecture and osteogenic progression. Therefore, graphite, fullerene, and diamond scaffolds with gradient stress stimulation to cells after deformation were prepared. The cellular biomechanical mechanisms of SASS through single-cell RNA sequencing indicated that architectures providing SASS can induce the enrichment of focal adhesion and osteogenic differentiation pathways of bone mesenchymal stem cells and balance bone resorption of osteoclasts and bone formation of osteoblasts. Besides, SASS enhances bone regeneration for repairing critical-sized defects in vivo. These results provide insights for artificial bone scaffold design and clarify the biomechanical cues between SASS and osteogenic progression.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv8804","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical control of single-atom dynamics in plasmonic nanogaps 等离子体纳米隙中单原子动力学的光学控制

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adx3216

Paul Kerner, Rakesh Arul, Damien Thompson, Jeremy J. Baumberg, Bart de Nijs

{"title":"Optical control of single-atom dynamics in plasmonic nanogaps","authors":"Paul Kerner, Rakesh Arul, Damien Thompson, Jeremy J. Baumberg, Bart de Nijs","doi":"10.1126/sciadv.adx3216","DOIUrl":"10.1126/sciadv.adx3216","url":null,"abstract":"<div >Observing and controlling dynamics of single atoms in ambient conditions is challenging when using conventional atomic-scale techniques due to their invasive character. Here, such control is achieved optically, by confining pulses of visible light within extreme plasmonic nanogaps, where they rapidly create (“write”) an adatom on one facet surface. Such adatoms are shown to be storable in ambient conditions for at least a week in the dark and are observed (“read”) using low-intensity surface-enhanced Raman spectroscopy (SERS). Writing at higher optical intensities stabilizes the atomic protrusion through light-induced local restructuring, which imposes a higher energy barrier for its return into the metal surface. Fluctuations in these “picocavity” SERS spectra show that while adatom movement is significantly slower under low light intensities, ambient thermal energy still enables them to explore the surrounding energetic landscape. Optical control over single metal atom dynamics opens promising avenues for next-generation microelectronics, atomic-scale imaging, and catalysis.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx3216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nicotinamide boosts oocyte quantity and quality by promoting N4-acetylation modification in lupus mice 烟酰胺通过促进狼疮小鼠n4乙酰化修饰提高卵母细胞数量和质量

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adu0955

Yun Xie, Chuanchuan Zhou, Qi Guo, Yingchun Guo, Jiayi Guo, Lina Chen, Xiaoping Liu, Yanyan Zeng, Qiqi Liang, Taibao Wu, Jiawen Liu, Xiaoyan Liang

{"title":"Nicotinamide boosts oocyte quantity and quality by promoting N4-acetylation modification in lupus mice","authors":"Yun Xie, Chuanchuan Zhou, Qi Guo, Yingchun Guo, Jiayi Guo, Lina Chen, Xiaoping Liu, Yanyan Zeng, Qiqi Liang, Taibao Wu, Jiawen Liu, Xiaoyan Liang","doi":"10.1126/sciadv.adu0955","DOIUrl":"10.1126/sciadv.adu0955","url":null,"abstract":"<div >Patients with systemic lupus erythematosus (SLE) often have decreased fertility. Gene translation is crucial to oocyte meiosis and development. However, it remains unclear how SLE affects this process. Here, we used single-cell transcriptome and translatome sequencing to uncover a notable disruption in protein translation in oocytes from SLE mice, associated with the <i>N</i><sup>4</sup>-acetylcytidine (ac<sup>4</sup>C) modification. Inhibition of ac<sup>4</sup>C levels in vitro substantially reduced oocyte translation efficiency. Notably, through trace-cell ac<sup>4</sup>C-RNA immunoprecipitation (acRIP) sequencing, we mapped the ac<sup>4</sup>C landscape in SLE mouse oocytes and found that deficient ac<sup>4</sup>C modification substantially impaired the translation of <i>Zygote arrest 1</i>. Furthermore, we demonstrated that nicotinamide treatment notably and safely improved the quantity and quality of oocytes in SLE mice by enhancing ac<sup>4</sup>C modification levels. Our findings highlight the essential role of <i>N</i>- acetyltransferase 10 (NAT10)-mediated ac<sup>4</sup>C modification in abnormal oocyte development in SLE and suggest that nicotinamide holds promise for improving fertility in patients with SLE.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu0955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteolytic-resistant self-assembling peptide nanofibers combat specific bacterial infections via trap and kill 抗蛋白水解自组装肽纳米纤维通过诱捕和杀伤来对抗特定的细菌感染

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adx0153

Weikang Yu, Mengyi Zhao, Xu Guo, Xiangwan Wang, Jiajun Wang, Yinfeng Lyu, Anshan Shan

{"title":"Proteolytic-resistant self-assembling peptide nanofibers combat specific bacterial infections via trap and kill","authors":"Weikang Yu, Mengyi Zhao, Xu Guo, Xiangwan Wang, Jiajun Wang, Yinfeng Lyu, Anshan Shan","doi":"10.1126/sciadv.adx0153","DOIUrl":"10.1126/sciadv.adx0153","url":null,"abstract":"<div >The rise in global antibiotic resistance highlights the urgent need for effective antimicrobial agents. Antimicrobial peptides (AMPs) offer a potential solution to combat bacterial resistance. However, key challenges remain in addressing the limitations of current peptide drugs and biomaterials, such as narrow action modes, poor protease stability, and challenges in pathogen-specific targeting. This study introduces a series of multifunctional AMPs by integrating self-assembling systems. By regulating the length of cationic amino acid side chains, the optimized peptide Nhar was identified as a triple-functional candidate with the potential to solve these limitations. In aqueous solutions, Nhar self-assembles into nanofibers that trap pathogens, prevent their spread, and selectively kill Gram-positive bacteria. Nhar demonstrates remarkable protease resistance, retaining antimicrobial activity even under protease conditions (10 milligrams per milliliter). It induces bacterial death primarily through membrane disruption and multiple synergistic mechanisms. In a <i>Staphylococcus aureus</i>–induced mouse bacteremia model, Nhar showed promising therapeutic potential. This work offers important insights for developing multifunctional antimicrobial therapies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx0153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ternary Schottky-p-n heterojunction strategy for enhancing photothermal dry reforming of methane 促进甲烷光热干重整的三元Schottky-p-n异质结策略

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adv5078

Qingqing Zhang, Ziyu Chen, Yutao Ye, Chang Xu, Cong Liu, Xiaoming Cao, Jinlong Zhang, Juying Lei, Ziwei Ye, Lingzhi Wang

{"title":"Ternary Schottky-p-n heterojunction strategy for enhancing photothermal dry reforming of methane","authors":"Qingqing Zhang, Ziyu Chen, Yutao Ye, Chang Xu, Cong Liu, Xiaoming Cao, Jinlong Zhang, Juying Lei, Ziwei Ye, Lingzhi Wang","doi":"10.1126/sciadv.adv5078","DOIUrl":"10.1126/sciadv.adv5078","url":null,"abstract":"<div >Breaking the trade-off between activity and stability in catalysts for dry reforming of methane has long remained a huge challenge. Here, we demonstrate a ternary Schottky-p-n (TSPN) heterojunction strategy based on Ni-NiO-Sr<sub>2</sub>Nb<sub>2</sub>O<sub>7</sub> (NiO<i><sub>x</sub></i>/SNO) for photothermal dry reforming of methane. This approach achieves a stable syngas production rate of 10.54 moles per gram per hour, with a light-to-fuel efficiency of 28.3% and a CH<sub>4</sub> turnover frequency of 18 per second at 500°C generated by concentrated light irradiation. This low-temperature, high-rate activity benefits from the photoaccelerated CH<sub>4</sub>-to-H<sub>2</sub> process facilitated by the synergistic effect of NiO and Ni<sup>0</sup>. Furthermore, the light-induced spatial separation of dual reduction sites for CO<sub>2</sub> reduction (SNO) and H<sub>2</sub> evolution (Ni<sup>0</sup>) suppresses the reverse water-gas shift (RWGS) reaction, ensuring continuous supply of active oxygen and improving reaction stability. This finding is expected to substantially promote low-temperature photothermal catalytic technology in enhancing the selective conversion efficiency of C<sub>1</sub> molecules.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv5078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crustal faulting drives biological redox cycling in the deep subsurface 地壳断裂驱动深层地下生物氧化还原循环

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adx5372

Xiao Wu, Jianxi Zhu, Hongmei Yang, Yiping Yang, Xiaoju Lin, Xiaoliang Liang, Mang Lin, Barbara Sherwood Lollar, Kurt O. Konhauser, Hongping He

{"title":"Crustal faulting drives biological redox cycling in the deep subsurface","authors":"Xiao Wu, Jianxi Zhu, Hongmei Yang, Yiping Yang, Xiaoju Lin, Xiaoliang Liang, Mang Lin, Barbara Sherwood Lollar, Kurt O. Konhauser, Hongping He","doi":"10.1126/sciadv.adx5372","DOIUrl":"10.1126/sciadv.adx5372","url":null,"abstract":"<div >In the deep biosphere, where surface-derived substrates are depleted, microbial communities rely on redox pairs generated through water-rock reactions to sustain metabolism. A notable example of this is the production of hydrogen gas (H<sub>2</sub>) and oxidants from rock fracturing. However, the potential interactions between these initial redox pairs and a key subsurface element—iron (Fe)—remain underexplored. Here, we simulated radical-induced water splitting to investigate the formation and evolution of redox gradients. Our results show that in the presence of Fe, ferrous iron (Fe<sup>2+</sup>) was marginally oxidized to ferric iron (Fe<sup>3+</sup>) by low concentrations of oxidants, whereas Fe<sup>3+</sup> was efficiently reduced back to Fe<sup>2+</sup> by reactive hydrogen atoms (•H). We propose that crustal faulting can generate various redox pairs and drive Fe redox cycling, thereby providing a sustained energy source for subsurface life on Earth and potentially on other planetary bodies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx5372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Present-day Earth mantle structure set up by crustal pollution of the basal magma ocean 现今地幔结构是由基底岩浆海洋的地壳污染所建立的

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.adu2072

Maxim D. Ballmer, Rob J. Spaargaren, Ananya Mallik, Antonio Manjón-Cabeza Córdoba, Miki Nakajima, Kenny Vilella

{"title":"Present-day Earth mantle structure set up by crustal pollution of the basal magma ocean","authors":"Maxim D. Ballmer, Rob J. Spaargaren, Ananya Mallik, Antonio Manjón-Cabeza Córdoba, Miki Nakajima, Kenny Vilella","doi":"10.1126/sciadv.adu2072","DOIUrl":"10.1126/sciadv.adu2072","url":null,"abstract":"<div >The crystallization of a global magma ocean during early terrestrial planet evolution and the subsequent segregation of a longer-lived “basal magma ocean” (BMO) atop the core set up the evolution of the mantle-atmosphere system. Although seismic evidence for a BMO exists on present-day Mars and the Moon, the Earth’s BMO is (near-)completely solidified. Seismically observed “large low-velocity provinces” (LLVPs) are thought to have resulted from the canonical “fractional” style of BMO crystallization. However, we show using thermodynamic modeling that BMO fractional crystallization yields lowermost-mantle densities much higher than those of LLVPs. In turn, pollution of the BMO by progressive addition of recycled basaltic crust and related “reactive crystallization” can reconcile LLVP volumes, densities, and compositions. This model also makes testable predictions of the compositions of “ultralow-velocity zones,” enigmatic deep Earth seismic domains, and possible BMO remnants. The critical role of crustal pollution elucidates the survival of a BMO on Mars, but implies an Earth-like fate for any Venusian BMO.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu2072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi 气候对感染和未感染伯氏疏螺旋体的蜱有不同的影响

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-18 DOI: 10.1126/sciadv.ads2181

Heather Broughton, Arielle Crews, Marie Lilly, Samantha Sambado, Jordan Salomon, Alexandra Lawrence, Kacie Ring, Jacoby Clark, Grace Shaw, Shannon Summers, Angie Nakano, Andrea Swei

{"title":"Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi","authors":"Heather Broughton, Arielle Crews, Marie Lilly, Samantha Sambado, Jordan Salomon, Alexandra Lawrence, Kacie Ring, Jacoby Clark, Grace Shaw, Shannon Summers, Angie Nakano, Andrea Swei","doi":"10.1126/sciadv.ads2181","DOIUrl":"10.1126/sciadv.ads2181","url":null,"abstract":"<div >Climate change continues to alter the behavior and distribution of species worldwide, with major ramifications for the transmission and risk of infectious diseases, including those caused by zoonotic vector-borne pathogens. This study explores the potential implications of climate change for one such pathogen, <i>Borrelia burgdorferi</i> (the causative agent of human Lyme disease), in <i>Ixodes pacificus</i> ticks of the far-western United States. Nymphal tick infection prevalence and density are compared against several metrics for climate, while also accounting for habitat fragmentation, mammalian species richness, and rodent tick burden to eliminate confounding variables. Findings show that climate extremes, such as those forecast with climate change, correlate with a reduction in <i>B. burgdorferi</i> prevalence in nymphal ticks despite nominal impacts on uninfected tick density, contrasting traditional hypotheses that these changes will increase vector-borne pathogens.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 29","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads2181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0