Science AdvancesPub Date : 2025-10-03DOI: 10.1126/sciadv.adx1178
Daniel X. Zhang, Michail N. Isupov, Rebecca M. Davies, Sabine Schwarzer, Mathew McLaren, William S. Stuart, Vicki A. M. Gold, Hanna M. Oksanen, Tessa E. F. Quax, Bertram Daum
{"title":"Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail","authors":"Daniel X. Zhang, Michail N. Isupov, Rebecca M. Davies, Sabine Schwarzer, Mathew McLaren, William S. Stuart, Vicki A. M. Gold, Hanna M. Oksanen, Tessa E. F. Quax, Bertram Daum","doi":"10.1126/sciadv.adx1178","DOIUrl":"10.1126/sciadv.adx1178","url":null,"abstract":"<div >While archaeal viruses show a stunning diversity of morphologies, many bear a notable resemblance to tailed bacterial phages. This raises fundamental questions: Do all tailed viruses share a common origin and do they infect their hosts in similar ways? Answering these questions requires high-resolution structural insights, yet no complete atomic models of archaeal viruses have been available. Here, we present the near-atomic resolution structure of Haloferax tailed virus 1 (HFTV1), an archaeal virus thriving in extreme salinity. Using cryo–electron microscopy, we resolve the architecture and assembly of all structural proteins and capture conformational transitions associated with DNA ejection. Our data reveal genome spooling within the capsid and identify putative receptor-binding and catalytic sites for host recognition and infection. These findings uncover key mechanisms of archaeal virus assembly, principles of virus-host interactions, and evolutionary links connecting archaeal, bacterial, and eukaryotic viruses.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx1178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Revealing atomic-scale switching pathways in van der Waals ferroelectrics","authors":"Xinyan Li, Kenna Ashen, Chuqiao Shi, Nannan Mao, Saagar Kolachina, Kaiwen Yang, Tianyi Zhang, Sajid Husain, Ramamoorthy Ramesh, Jing Kong, Xiaofeng Qian, Yimo Han","doi":"10.1126/sciadv.adw3295","DOIUrl":"10.1126/sciadv.adw3295","url":null,"abstract":"<div >Two-dimensional (2D) van der Waals (vdW) materials hold the potential for ultrascaled ferroelectric (FE) devices due to their silicon compatibility and robust polarization down to atomic scale. However, the inherently weak vdW interactions enable facile sliding between layers, introducing complexities beyond those encountered in conventional ferroelectric materials and presenting substantial challenges in uncovering intricate switching pathways. Here, we combine atomic-resolution imaging under in situ electrical biasing conditions with first-principles calculations to unravel the atomic-scale switching mechanisms in SnSe, a vdW group IV monochalcogenide. Our results uncover the coexistence of a consecutive 90° switching pathway and a direct 180° switching pathway from antiferroelectric (AFE) to FE order in this vdW system. Atomic-scale investigations and strain analysis reveal that the switching processes simultaneously induce interlayer sliding and compressive strain, while the lattice remains coherent despite the presence of multidomain structures. These findings elucidate vdW ferroelectric switching dynamics at atomic scale and lay the foundation for the rational design of 2D ferroelectric nanodevices.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw3295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systematic evolution of superconducting pairing strength and Seebeck coefficients in correlated infinite-layer La1–xSrxNiO2","authors":"Motoki Osada, Shusaku Imajo, Yuji Seki, Kousuke Ishida, Tsutomu Nojima, Kohei Fujiwara, Koichi Kindo, Yusuke Nomura, Atsushi Tsukazaki","doi":"10.1126/sciadv.adv6488","DOIUrl":"10.1126/sciadv.adv6488","url":null,"abstract":"<div >The recently found superconducting infinite-layer nickelates offer a unique platform to explore an exotic pairing mechanism in multiband systems toward high-temperature superconductivity and associated rich quantum phases, contrasting with cuprates. Here, we show that infinite-layer (La,Sr)NiO<sub>2</sub> exhibits strong-coupling superconductivity, resilient to in-plane magnetic fields exceeding 47 tesla at optimal doping—more than twice the Pauli limit for conventional Bardeen-Cooper-Schrieffer superconductors. This violation becomes pronounced toward the underdoped regime, implying an intriguing evolution of pairing glue. The unexpected observation of positive Seebeck coefficients in this regime indicates the presence of nontrivial electron correlations. Furthermore, our comprehensive investigation across the superconducting dome reveals that the evolution of (thermo)electric normal-state properties—specifically, the sign changes of the Hall and Seebeck coefficients—coincides with the evolution of superconducting anisotropy and pairing strength. This demonstrates a definitive link between electron correlations and strong-coupling superconductivity in (La,Sr)NiO<sub>2</sub>, contributing to a unified framework for understanding unconventional superconductivity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv6488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-03DOI: 10.1126/sciadv.adu2973
Hiroki Yoshida, Hikaru Takeda, Jian Yan, Yui Kanemori, Brenden R. Ortiz, Yuzki M. Oey, Stephen D. Wilson, Marcin Konczykowski, Kota Ishihara, Takasada Shibauchi, Minoru Yamashita
{"title":"Observation of anomalous thermal Hall effect in a Kagome superconductor","authors":"Hiroki Yoshida, Hikaru Takeda, Jian Yan, Yui Kanemori, Brenden R. Ortiz, Yuzki M. Oey, Stephen D. Wilson, Marcin Konczykowski, Kota Ishihara, Takasada Shibauchi, Minoru Yamashita","doi":"10.1126/sciadv.adu2973","DOIUrl":"10.1126/sciadv.adu2973","url":null,"abstract":"<div >Broken time-reversal symmetry (TRS) in superconductors can induce not only spontaneous magnetization by the finite angular momentum of Cooper pairs but also the anomalous thermal Hall effects (ATHEs), whose detection has been extremely challenging. Here, we report the successful observation of an ATHE developing below the superconducting transition temperature at zero magnetic field in the kagome-lattice superconductor CsV<sub>3</sub>Sb<sub>5</sub>. This finding is verified by the absence of a signal in a conventional type-II superconductor using the same setup and by ruling out the trapped-vortex effects through micro-Hall array measurements. Both the temperature dependence and the magnitude of the observed anomalous thermal Hall conductivity are quite different from those expected for the quantized thermal edge current of an intrinsic ATHE but consistent with extrinsic impurity-induced ATHEs in chiral superconductivity. Our study of ATHE offers an alternative approach to probe TRS breaking in the superconducting states.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu2973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-03DOI: 10.1126/sciadv.adt5419
Alexander D. Meyer, Sandra Mendoza Guerrero, Natalie E. Dean, Kathryn B. Anderson, Steven T. Stoddard, T. Alex Perkins
{"title":"Predictability of infectious disease outbreak severity: Chikungunya as a case study","authors":"Alexander D. Meyer, Sandra Mendoza Guerrero, Natalie E. Dean, Kathryn B. Anderson, Steven T. Stoddard, T. Alex Perkins","doi":"10.1126/sciadv.adt5419","DOIUrl":"10.1126/sciadv.adt5419","url":null,"abstract":"<div >A single pathogen can cause outbreaks of varying size and duration in different populations. Anticipating severe outbreaks would facilitate public health preparedness, but the extent to which this is possible is unclear. We conducted a data-driven investigation into the predictability of outbreak severity, using chikungunya virus (CHIKV) as a case study. For mosquito-transmitted viruses like CHIKV, the potential for severe outbreaks is often assessed using climate-based estimates of the basic reproduction number, <span><math><mrow><msub><mi>R</mi><mn>0</mn></msub></mrow></math></span> . We derived a large set of <span><math><mrow><msub><mi>R</mi><mn>0</mn></msub></mrow></math></span> estimates for CHIKV by fitting a mechanistic model to data from 86 chikungunya outbreaks. These <span><math><mrow><msub><mi>R</mi><mn>0</mn></msub></mrow></math></span> estimates were weakly predicted by climatic and other factors. Among deterministic drivers of outbreak severity, the contribution of <span><math><mrow><msub><mi>R</mi><mn>0</mn></msub></mrow></math></span> was comparable to that of generation interval length, transmission distance, and population network structure. While aspects of chikungunya outbreak severity are predictable, innovative approaches are needed that look beyond the impacts of climate on <span><math><mrow><msub><mi>R</mi><mn>0</mn></msub></mrow></math></span>.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt5419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-03DOI: 10.1126/sciadv.adw3856
Alexander Guthmann, Felix Lang, Louisa Marie Kienesberger, Sian Barbosa, Artur Widera
{"title":"Floquet engineering of Feshbach resonances in ultracold gases","authors":"Alexander Guthmann, Felix Lang, Louisa Marie Kienesberger, Sian Barbosa, Artur Widera","doi":"10.1126/sciadv.adw3856","DOIUrl":"10.1126/sciadv.adw3856","url":null,"abstract":"<div >Scattering resonances are fundamental to many areas of physics, occurring across a wide range of energy scales. In ultracold quantum gases, magnetic Feshbach resonances have transformed quantum many-body research by enabling precise interaction control between atoms. Here, we demonstrate unprecedented control to engineer Feshbach resonances at tunable positions via Floquet driving in a lithium-6 (^{6}Li) atom gas, achieved through strong magnetic field modulation at megacycles per second frequencies. This periodic modulation creates scattering resonances whenever dressed molecular levels cross the atomic threshold. By adding a second modulation at twice the base frequency, we tune the asymmetry of resonance loss profiles and suppress two-body losses from Floquet heating. This technique enhances control over atomic interactions, expanding possibilities for quantum simulations of complex systems and studies of exotic quantum phases.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw3856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-03DOI: 10.1126/sciadv.adw7376
Valentina Cianfanelli, Monica Nanni, Samantha Corrà, Sofia Mauri, David Sumpton, Sergio Lilla, Rossella De Cegli, Matteo Bordi, Giacomo Milletti, Caterina Ferraina, Arnaldur Hall, Michele Petraroia, Valentina Clausi, Ezio Giorda, Marco Scarsella, Alessandra Barbiera, Giulia Cadeddu, Marco Colasanti, Tiziana Persichini, Kenji Maeda, Apolinar Maya-Mendoza, Jiri Bartek, Chiara Di Malta, Franco Locatelli, Sara Zanivan, Shehab Ismail, Elena Ziviani, Francesco Cecconi
{"title":"The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis","authors":"Valentina Cianfanelli, Monica Nanni, Samantha Corrà, Sofia Mauri, David Sumpton, Sergio Lilla, Rossella De Cegli, Matteo Bordi, Giacomo Milletti, Caterina Ferraina, Arnaldur Hall, Michele Petraroia, Valentina Clausi, Ezio Giorda, Marco Scarsella, Alessandra Barbiera, Giulia Cadeddu, Marco Colasanti, Tiziana Persichini, Kenji Maeda, Apolinar Maya-Mendoza, Jiri Bartek, Chiara Di Malta, Franco Locatelli, Sara Zanivan, Shehab Ismail, Elena Ziviani, Francesco Cecconi","doi":"10.1126/sciadv.adw7376","DOIUrl":"10.1126/sciadv.adw7376","url":null,"abstract":"<div >Mitochondrial homeostasis relies on a tight balance between mitochondrial biogenesis and degradation. Although mitophagy is one of the main pathways involved in the clearance of damaged or old mitochondria, its coordination with mitochondrial biogenesis is poorly characterized. Here, by unbiased approaches including last-generation liquid chromatography coupled to mass spectrometry and transcriptomics, we identify the protein phosphatase PP2A-B55α/PPP2R2A as a Parkin-dependent regulator of mitochondrial number. Upon mitochondrial damage, PP2A-B55α determines the amplitude of mitophagy induction and execution by regulating both early and late mitophagy events. A few minutes after the insult, ULK1 is released from the inhibitory regulation of PP2A-B55α, whereas 2 to 4 hours later, PP2A-B55α promotes the nuclear translocation of TFEB, the master regulator of autophagy and lysosome genes, to support mitophagy execution. Moreover, PP2A-B55α controls a transcriptional program of mitochondrial biogenesis by stabilizing the Parkin substrate and PGC-1α inhibitor PARIS. PP2A-B55α targeting rescues neurodegenerative phenotypes in a fly model of Parkinson’s disease, thus suggesting potential therapeutic application.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-03DOI: 10.1126/sciadv.ady3258
James S. Pierce, David A. D. Evans, Dana E. Polomski, Nasrrddine Youbi, Mohamed A. Mediany, Jihane Ounar, Rachid Oukhro, M. Ahmed Boumehdi, Justin V. Strauss, C. Brenhin Keller, Andres Gärtner, Maria Ovtcharova, Jörn-Frederik Wotzlaw, Ulf Linnemann
{"title":"Magnetostratigraphic constraints on the late Ediacaran paleomagnetic enigma","authors":"James S. Pierce, David A. D. Evans, Dana E. Polomski, Nasrrddine Youbi, Mohamed A. Mediany, Jihane Ounar, Rachid Oukhro, M. Ahmed Boumehdi, Justin V. Strauss, C. Brenhin Keller, Andres Gärtner, Maria Ovtcharova, Jörn-Frederik Wotzlaw, Ulf Linnemann","doi":"10.1126/sciadv.ady3258","DOIUrl":"10.1126/sciadv.ady3258","url":null,"abstract":"<div >Paleogeography of the Ediacaran Period has remained poorly understood because of paleomagnetic studies commonly yielding perplexing or conflicting data. Here, we report new magnetostratigraphic data from the Ediacaran Ouarzazate Group in the Anti-Atlas Mountains of Morocco, which have primary magnetizations supported by a positive conglomerate test and stratigraphically consistent directions within volcanic units across multiple localities. Comprehensive magnetostratigraphic sampling shows highly variable directions, consistent with a rapidly changing geomagnetic field along a longitudinally preferred band. High-precision geochronology constrains the geomagnetic variability to ~568 to 562 million years and suggests rates that are likely too rapid for true polar wander or plate tectonic interpretations. Comparison of igneous- and sedimentary-derived data, using a new statistical approach combining Bingham and Fisher distributions, indicates a high-inclination paleomagnetic direction that is compatible with independent evidence for regional glaciation. Our analysis produces a late Ediacaran paleogeographic reconstruction that is consistent with paleomagnetic and geologic constraints.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady3258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-03DOI: 10.1126/sciadv.adz7406
Jie Shen, Antoine Cornet, Alberto Ronca, Eloi Pineda, Fan Yang, Jean-Luc Garden, Gael Moiroux, Gavin Vaughan, Marco di Michiel, Gaston Garbarino, Fabian Westermeier, Celine Goujon, Murielle Legendre, Jiliang Liu, Daniele Cangialosi, Beatrice Ruta
{"title":"Linking the pressure dependence of the structure and thermal stability to α- and β-relaxations in metallic glasses","authors":"Jie Shen, Antoine Cornet, Alberto Ronca, Eloi Pineda, Fan Yang, Jean-Luc Garden, Gael Moiroux, Gavin Vaughan, Marco di Michiel, Gaston Garbarino, Fabian Westermeier, Celine Goujon, Murielle Legendre, Jiliang Liu, Daniele Cangialosi, Beatrice Ruta","doi":"10.1126/sciadv.adz7406","DOIUrl":"10.1126/sciadv.adz7406","url":null,"abstract":"<div >Glasses derive their functional properties from complex relaxation dynamics that remain enigmatic under extreme conditions. Although the temperature dependence of these relaxation processes is well established, their behavior under high-pressure conditions remains poorly understood due to substantial experimental difficulties. In this study, we use cutting-edge experimental techniques to probe the pressure evolution of the relaxation spectrum in a Zr<sub>46.8</sub>Ti<sub>8.2</sub>Cu<sub>7.5</sub>Ni<sub>10</sub>Be<sub>27.5</sub> metallic glass across gigapascal pressure ranges. Our findings reveal two distinct relaxation mechanisms under high pressure: In the β-relaxation regime, compression drives the system with reduced atomic mobility and enhanced structural disorder, without appreciable density changes. Conversely, α-relaxation under pressure promotes density-driven structural ordering that improves thermal stability. Notably, the transition between these regimes occurs at a constant <i>T</i>/<i>T</i><sub>g,P</sub> ratio, independent of applied pressure. These results provide crucial insights for decoupling the competing structural and relaxation contributions to glass stability, establishing a systematic framework for tailoring glass properties through controlled thermomechanical processing.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 40","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz7406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}