Science Advances最新文献_第8页

Harnessing huge data from pregnancy natural experiments

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adw6818

Michelle Oyen

引用次数: 0

Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adr9916

Hongli Wang, Heather K. Ortega, Emma B. Kelly, Jonathan Indajang, Neil K. Savalia, Samira Glaeser-Khan, Jiesi Feng, Yulong Li, Alfred P. Kaye, Alex C. Kwan

{"title":"Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making","authors":"Hongli Wang, Heather K. Ortega, Emma B. Kelly, Jonathan Indajang, Neil K. Savalia, Samira Glaeser-Khan, Jiesi Feng, Yulong Li, Alfred P. Kaye, Alex C. Kwan","doi":"10.1126/sciadv.adr9916","DOIUrl":"10.1126/sciadv.adr9916","url":null,"abstract":"<div >Norepinephrine (NE) and acetylcholine (ACh) are crucial for learning and decision-making. In the cortex, NE and ACh are released transiently at specific sites along neuromodulatory axons, but how the spatiotemporal patterns of NE and ACh signaling link to behavioral events is unknown. Here, we use two-photon microscopy to visualize neuromodulatory signals in the premotor cortex (medial M2) as mice engage in a competitive matching pennies game. Spatially, NE signals are more segregated with choice and outcome encoded at distinct locations, whereas ACh signals can multiplex and reflect different behavioral correlates at the same site. Temporally, task-driven NE transients were more synchronized and peaked earlier than ACh transients. To test functional relevance, we stimulated neuromodulatory signals using optogenetics to find that NE, but not ACh, increases the animals’ propensity to explore alternate options. Together, the results reveal distinct subcellular spatiotemporal patterns of ACh and NE transients during decision-making in mice.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr9916","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage-targeted Mms6 mRNA-lipid nanoparticles promote locomotor functional recovery after traumatic spinal cord injury in mice

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.ads2295

Chunyan Fu, Xiaoqin Jin, Kangfan Ji, Ke Lan, Xingjia Mao, Zhaobo Huang, Jian Chen, Fengdong Zhao, Pengfei Li, Xuefei Hu, Liwen Sun, Ning Lu, Jinjie Zhong, Yingying Chen, Linlin Wang

{"title":"Macrophage-targeted Mms6 mRNA-lipid nanoparticles promote locomotor functional recovery after traumatic spinal cord injury in mice","authors":"Chunyan Fu, Xiaoqin Jin, Kangfan Ji, Ke Lan, Xingjia Mao, Zhaobo Huang, Jian Chen, Fengdong Zhao, Pengfei Li, Xuefei Hu, Liwen Sun, Ning Lu, Jinjie Zhong, Yingying Chen, Linlin Wang","doi":"10.1126/sciadv.ads2295","DOIUrl":"10.1126/sciadv.ads2295","url":null,"abstract":"<div >Traumatic spinal cord injury (SCI) causes severe central nervous system damage. M2 macrophages within the lesion are crucial for SCI recovery. Our previous research revealed that M2 macrophages transfected with magnetotactic bacteria–derived <i>Mms6</i> gene can resist ferroptosis and enhance SCI recovery. To address the limitations of M2 macrophage transplantation, we developed lipid nanoparticles (LNPs) encapsulating <i>Mms6</i> mRNA targeting macrophages (<i>Mms6</i> mRNA-PS/LNPs). The targeting efficiency and therapeutic effect of these LNPs in SCI mice were evaluated. Intravenous administration of <i>Mms6</i> mRNA-PS/LNPs delivered more <i>Mms6</i> mRNAs to lesion-site macrophages than those in the <i>Mms6</i> mRNA-LNP group, which resulted in enhancing motor function recovery, reducing lesion area and scar formation, and promoting neuronal survival and nerve fiber repair. These effects were nullified when macrophages were depleted. These findings suggest that macrophage-targeted delivery of <i>Mms6</i> mRNA is a promising therapeutic strategy for promoting spinal cord repair and motor function recovery in patients with traumatic SCI.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads2295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy and postpartum dynamics revealed by millions of lab tests

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adr7922

Alon Bar, Ron Moran, Netta Mendelsohn-Cohen, Yael Korem Kohanim, Avi Mayo, Yoel Toledano, Uri Alon

{"title":"Pregnancy and postpartum dynamics revealed by millions of lab tests","authors":"Alon Bar, Ron Moran, Netta Mendelsohn-Cohen, Yael Korem Kohanim, Avi Mayo, Yoel Toledano, Uri Alon","doi":"10.1126/sciadv.adr7922","DOIUrl":"10.1126/sciadv.adr7922","url":null,"abstract":"<div >Pregnancy and delivery involve dynamic alterations in many physiological systems. However, the physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human population. Here, we present the dynamics of 76 lab tests based on a cross-sectional analysis of 44 million measurements from over 300,000 pregnancies. We analyzed each test at weekly intervals from 20 weeks preconception to 80 weeks postpartum, providing detailed temporal profiles. About half of the tests take 3 months to a year to return to baseline postpartum, highlighting the physiological load of childbirth. The precision of the data revealed effects of preconception supplements, overshoots after delivery and intricate temporal responses to changes in blood volume and renal filtration rate. Pregnancy complications—gestational diabetes, preeclampsia, and postpartum hemorrhage—showed distinct dynamical changes. These results provide a comprehensive dynamic portrait of the systems physiology of pregnancy.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr7922","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing cancer therapeutic efficacy in vivo using [2H7]glucose deuterium metabolic imaging

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adr0568

Mario C. Chang, Vinay R. Malut, Rohit Mahar, Anna Rushin, Marc A. McLeod, Geraldine L. Pierre, Indu R. Malut, Stephen J. Staklinski, Max E. Glanz, Mukundan Ragavan, Gaurav Sharma, Manoj Madheswaran, Arshee Badar, Aparna D. Rao, Brian K. Law, Michael S. Kilberg, James H. P. Collins, Vikram D. Kodibagkar, James A. Bankson, Ralph J. DeBerardinis, Matthew E. Merritt

{"title":"Assessing cancer therapeutic efficacy in vivo using [2H7]glucose deuterium metabolic imaging","authors":"Mario C. Chang, Vinay R. Malut, Rohit Mahar, Anna Rushin, Marc A. McLeod, Geraldine L. Pierre, Indu R. Malut, Stephen J. Staklinski, Max E. Glanz, Mukundan Ragavan, Gaurav Sharma, Manoj Madheswaran, Arshee Badar, Aparna D. Rao, Brian K. Law, Michael S. Kilberg, James H. P. Collins, Vikram D. Kodibagkar, James A. Bankson, Ralph J. DeBerardinis, Matthew E. Merritt","doi":"10.1126/sciadv.adr0568","DOIUrl":"10.1126/sciadv.adr0568","url":null,"abstract":"<div >Metabolic imaging produces powerful visual assessments of organ function in vivo. Current techniques can be improved by safely increasing metabolic contrast. The gold standard, 2-[<sup>18</sup>F]fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging, is limited by radioactive exposure and sparse assessment of metabolism beyond glucose uptake and retention. Deuterium magnetic resonance imaging (DMRI) with [6,6-<sup>2</sup>H<sub>2</sub>]glucose is nonradioactive, achieves tumor metabolic contrast, but can be improved by enriched contrast from deuterated water (HDO) based imaging. Here, we developed a DMRI protocol employing [<sup>2</sup>H<sub>7</sub>]glucose. Imaging <sup>2</sup>H-signal and measuring HDO production in tumor-bearing mice detected differential glucose utilization across baseline tumors, tumors treated with vehicle control or anti-glycolytic BRAFi and MEKi therapy, and contralateral healthy tissue. Control tumors generated the most <sup>2</sup>H-signal and HDO. To our knowledge this is the first application of DMRI with [<sup>2</sup>H<sub>7</sub>]glucose for tumoral treatment monitoring. This approach demonstrates HDO as a marker of tumor glucose utilization and suggests translational capability in humans due to its safety, noninvasiveness, and suitability for serial monitoring.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr0568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sub-wavelength optical lattice in 2D materials

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adv2023

Supratik Sarkar, Mahmoud Jalali Mehrabad, Daniel G. Suárez-Forero, Liuxin Gu, Christopher J. Flower, Lida Xu, Kenji Watanabe, Takashi Taniguchi, Suji Park, Houk Jang, You Zhou, Mohammad Hafezi

{"title":"Sub-wavelength optical lattice in 2D materials","authors":"Supratik Sarkar, Mahmoud Jalali Mehrabad, Daniel G. Suárez-Forero, Liuxin Gu, Christopher J. Flower, Lida Xu, Kenji Watanabe, Takashi Taniguchi, Suji Park, Houk Jang, You Zhou, Mohammad Hafezi","doi":"10.1126/sciadv.adv2023","DOIUrl":"10.1126/sciadv.adv2023","url":null,"abstract":"<div >Recently, light-matter interaction has been vastly expanded as a control tool for inducing and enhancing many emergent nonequilibrium phenomena. However, conventional schemes for exploring such light-induced phenomena rely on uniform and diffraction-limited free-space optics, which limits the spatial resolution and the efficiency of light-matter interaction. Here, we overcome these challenges using metasurface plasmon polaritons (MPPs) to form a sub-wavelength optical lattice. Specifically, we report a “nonlocal” pump-probe scheme where MPPs are excited to induce a spatially modulated AC Stark shift for excitons in a monolayer of MoSe<sub>2</sub>, several microns away from the illumination spot. We identify nearly two orders of magnitude reduction for the required modulation power compared to the free-space optical illumination counterpart. Moreover, we demonstrate a broadening of the excitons’ linewidth as a robust signature of MPP-induced periodic sub-diffraction modulation. Our results will allow exploring power-efficient light-induced lattice phenomena below the diffraction limit in active chip-compatible MPP architectures.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv2023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphorylation at serine-260 of Toc33 is essential for chloroplast biogenesis

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adu4054

Yuan-Chi Chien, Gyeong Mee Yoon

引用次数: 0

Making continental crust on water-bearing terrestrial planets

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.ads6746

Justine Bernadet, Anastassia Y. Borisova, Martin Guitreau, Oleg G. Safonov, Paul Asimow, Anne Nédélec, Wendy A. Bohrson, Svetlana A. Kosova, Philippe de Parseval

{"title":"Making continental crust on water-bearing terrestrial planets","authors":"Justine Bernadet, Anastassia Y. Borisova, Martin Guitreau, Oleg G. Safonov, Paul Asimow, Anne Nédélec, Wendy A. Bohrson, Svetlana A. Kosova, Philippe de Parseval","doi":"10.1126/sciadv.ads6746","DOIUrl":"10.1126/sciadv.ads6746","url":null,"abstract":"<div >The debate about early Earth differentiation focuses on the processes responsible for the formation of protocrust(s) and continental crust of felsic (SiO<sub>2</sub> ≥ 55 weight %) composition. One aspect of this debate is how Hadean zircons fit into an ultramafic environment. On the basis of experiments, thermodynamic modeling, and elemental partitioning, we show that felsic melts could have been generated by shallow interaction between primordial serpentinized peridotite and basaltic magmas on Earth and Mars. On the basis of the hafnium isotopic evolution of Hadean detrital zircons worldwide, we infer that these interactions allowed for the formation of extensive Hadean felsic crust (4.4 to 4.5 billion years ago), which, in turn, would account for up to 50% of the present continental crustal mass. A similar process may have occurred on Mars. The serpentinized protocrust had a dual role in the primitive planetary environment: to provide ingredients for the continental crust and to enable life to emerge on water-bearing terrestrial planets.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads6746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoelectronics-enabled reservoir computing hardware for real-time robotic controls

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adu2663

Mingze Chen, Xiaoqiu An, Seung Jun Ki, Xirong Liu, Nihal Sekhon, Artyom Boyarov, Anushka Acharya, Justin Tawil, Maxwell Bederman, Xiaogan Liang

{"title":"Nanoelectronics-enabled reservoir computing hardware for real-time robotic controls","authors":"Mingze Chen, Xiaoqiu An, Seung Jun Ki, Xirong Liu, Nihal Sekhon, Artyom Boyarov, Anushka Acharya, Justin Tawil, Maxwell Bederman, Xiaogan Liang","doi":"10.1126/sciadv.adu2663","DOIUrl":"10.1126/sciadv.adu2663","url":null,"abstract":"<div >Traditional robotic vehicle control algorithms, implemented on digital devices with firmware, result in high power consumption and system complexity. Advanced control systems based on different device physics are essential for the advancement of sophisticated robotic vehicles and miniature mobile robots. Here, we present a nanoelectronics-enabled analog control system mimicking conventional controllers’ dynamic responses for real-time robotic controls, substantially reducing training cost, power consumption, and footprint. This system uses a reservoir computing network with interconnected memristive channels made from layered semiconductors. The network’s nonlinear switching and short-term memory characteristics effectively map input sensory signals to high-dimensional data spaces, enabling the generation of motor control signals with a simply trained readout layer. This approach minimizes software and analog-to-digital conversions, enhancing energy and resource efficiency. We demonstrate this system with two control tasks: rover target tracking and drone lever balancing, achieving similar performance to traditional controllers with ~10-microwatt power consumption. This work paves the way for ultralow-power edge computing in miniature robotic systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu2663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adt3142

Suowen Xu, Zhenghong Liu, Tian Tian, Wenqi Zhao, Zhihua Wang, Monan Liu, Mengyun Xu, Fanshun Zhang, Zhidan Zhang, Meijie Chen, Yanjun Yin, Meiming Su, Wenxiang Fang, Wenhao Pan, Shiyong Liu, Min-dian Li, Peter J. Little, Danielle Kamato, Songyang Zhang, Dongdong Wang, Stefan Offermanns, John R. Speakman, Jianping Weng

{"title":"The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21","authors":"Suowen Xu, Zhenghong Liu, Tian Tian, Wenqi Zhao, Zhihua Wang, Monan Liu, Mengyun Xu, Fanshun Zhang, Zhidan Zhang, Meijie Chen, Yanjun Yin, Meiming Su, Wenxiang Fang, Wenhao Pan, Shiyong Liu, Min-dian Li, Peter J. Little, Danielle Kamato, Songyang Zhang, Dongdong Wang, Stefan Offermanns, John R. Speakman, Jianping Weng","doi":"10.1126/sciadv.adt3142","DOIUrl":"10.1126/sciadv.adt3142","url":null,"abstract":"<div >Obesity is a debilitating global pandemic with a huge cost on health care due to it being a major underlying risk factor for several diseases. Therefore, there is an unmet medical need for pharmacological interventions to curb obesity. Here, we report that halofuginone, a Food and Drug Administration–approved anti-scleroderma and antiprotozoal drug, is a promising anti-obesity agent in preclinical mouse and pig models. Halofuginone suppressed food intake, increased energy expenditure, and resulted in weight loss in diet-induced obese mice while also alleviating insulin resistance and hepatic steatosis. Using molecular and pharmacological tools with transcriptomics, we identified that halofuginone increases fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) levels via activating integrated stress response. Using <i>Gdf15</i> and <i>Fgf21</i> knockout mice, we show that both hormones are necessary to elicit anti-obesity changes. Together, our study reports the beneficial metabolic effects of halofuginone and underscores its utility in treating obesity and its associated metabolic complications, which merits clinical assessment.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt3142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0