Science Advances最新文献_第8页

Planetary Health Diet and risk of mortality and chronic diseases: Results from US NHANES, UK Biobank, and a meta-analysis 行星健康饮食与死亡和慢性病风险：来自美国NHANES、英国生物银行和荟萃分析的结果

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adq5147

Yuanyuan Wang, Da Pan, Chen Zhang, Dengfeng Xu, Yifei Lu, Shiyu Yin, Pei Wang, Jiayue Xia, Junhui Yu, Lirong Dong, Guiju Sun

引用次数: 0

Repurposing polyethylene terephthalate plastic waste to capture carbon dioxide 重新利用聚对苯二甲酸乙二醇酯塑料废物来捕获二氧化碳

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adv5906

Margarita Poderyte, Rodrigo Lima, Peter Illum Golbækdal, Dennis Wilkens Juhl, Kathrine L. Olesen, Niels Chr. Nielsen, Arianna Lanza, Ji-Woong Lee

{"title":"Repurposing polyethylene terephthalate plastic waste to capture carbon dioxide","authors":"Margarita Poderyte, Rodrigo Lima, Peter Illum Golbækdal, Dennis Wilkens Juhl, Kathrine L. Olesen, Niels Chr. Nielsen, Arianna Lanza, Ji-Woong Lee","doi":"10.1126/sciadv.adv5906","DOIUrl":"10.1126/sciadv.adv5906","url":null,"abstract":"<div >Polyethylene terephthalate (PET) is a ubiquitous polymer with a lack of viable waste management solutions besides mechanical recycling, incineration, and landfilling. Herein, we demonstrate a chemical upcycling of PET waste into materials for CO<sub>2</sub> capture via aminolysis. The aminolysis reaction products—a bis-aminoamide (BAETA) and oligomers—exhibit high CO<sub>2</sub> capture capacity up to 3.4 moles per kilogram as a stand-alone organic solid material. BAETA shows strong chemisorption featuring high selectivity for CO<sub>2</sub> capture from flue gas (5 to 20% CO<sub>2</sub>) and ambient air (~400 parts per million CO<sub>2</sub>) under humid conditions. Our thermally stable material (>250°C) enables CO<sub>2</sub> capture at high temperatures (up to 170°C) for multiple cycles. Scalability of the material production was demonstrated by performing aminolysis of untreated consumer waste PET of 1 kilogram. Our approach introduces a simple and straightforward solution that can address both plastic waste and carbon dioxide, offering a potential pathway toward net negative emissions.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv5906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of ketonyl C-glycosides from designed glycosyl sulfides and styrenes by a radical pathway 设计的糖基硫化物和苯乙烯自由基法制备酮基c -糖苷

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.ady2175

Weidong Shang, Yanan Hu, Yang He, Dawen Niu, Weimin Li

{"title":"Preparation of ketonyl C-glycosides from designed glycosyl sulfides and styrenes by a radical pathway","authors":"Weidong Shang, Yanan Hu, Yang He, Dawen Niu, Weimin Li","doi":"10.1126/sciadv.ady2175","DOIUrl":"10.1126/sciadv.ady2175","url":null,"abstract":"<div >Ketonyl <i>C</i>-glycosides, a vital subclass of alkyl <i>C</i>-glycosides, play essential roles in drug discovery, biochemistry, and materials sciences. However, a practical strategy that merges bench-stable glycosyl donors with styrenes—a ubiquitous class of synthetic building blocks—remains elusive. Herein, we report a simple and general approach for synthesizing ketonyl <i>C</i>-glycosides. The transformation uses designed glycosyl sulfides as air- and moisture-stable precursors to glycosyl radicals, styrenes as aglycone sources, and dimethyl sulfoxide as both an oxidant and solvent, proceeding under photoredox catalysis. Glycosyl radicals are generated from glycosyl sulfides via efficient unimolecular homolytic substitution. This approach obviates harsh conditions for donor activation and the use of activated aglycone precursors, accommodating extensive functional groups and heterocycles. The reaction also exhibits high stereoselectivity across various glycosyl units. Demonstrating synthetic versatility, this method enables efficient access to diverse drug-sugar conjugates and complex <i>C</i>-glycopeptidomimetics. Mechanistic studies reveal key intermediates, suggesting a radical-polar crossover pathway. This study offers a broadly applicable approach to valuable sugar-containing structures.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady2175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational design of potent and selective binders of BAK and BAX BAK和BAX强效和选择性结合剂的计算设计

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adt4170

Stephanie Berger, Erinna F. Lee, Tiffany J. Harris, Sharon Tran, Asim K. Bera, Lauren Arguinchona, Alex Kang, Banumathi Sankaran, Sila Kasapgil, Michelle S. Miller, Sean Smyth, Mariam Lutfi, Rachel T. Uren, Ruth M. Kluck, Peter M. Colman, Walter D. Fairlie, Peter E. Czabotar, David Baker, Richard W. Birkinshaw

{"title":"Computational design of potent and selective binders of BAK and BAX","authors":"Stephanie Berger, Erinna F. Lee, Tiffany J. Harris, Sharon Tran, Asim K. Bera, Lauren Arguinchona, Alex Kang, Banumathi Sankaran, Sila Kasapgil, Michelle S. Miller, Sean Smyth, Mariam Lutfi, Rachel T. Uren, Ruth M. Kluck, Peter M. Colman, Walter D. Fairlie, Peter E. Czabotar, David Baker, Richard W. Birkinshaw","doi":"10.1126/sciadv.adt4170","DOIUrl":"10.1126/sciadv.adt4170","url":null,"abstract":"<div >Potent and selective binders of the key proapoptotic proteins BAK and BAX have not been described. We use computational protein design to generate high affinity binders of BAK and BAX with greater than 100-fold specificity for their target. Both binders activate their targets when at low concentration, driving pore formation, but inhibit membrane permeabilization when in excess. Crystallography shows that the BAK binder induces BAK unfolding, exposing the α6 helix and BH3 domain. Together, these data suggest that upon binding, BAK or BAX unfold; at high binder concentrations, self-association of the partially folded BAK or BAX proteins is blocked and the membrane remains intact, whereas at low concentrations, dimers form, and the membrane ruptures. Our designed binders modulate apoptosis via direct, specific interactions with BAK and BAX and reveal that for therapeutic strategies targeting BAK and BAX, inhibition requires saturating binder concentrations at the site of action.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt4170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis 用于移植中靶向抗体去除的声流系统：实现小体积治疗性单采

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.ady3262

Zhiteng Ma, Riley Kahan, Jianping Xia, Mengxi Wu, Brandon Lu, Emeraghi David, Ye He, Ying Chen, Jessica F. Liu, Mingyuan Liu, Haojun Xu, Linda Stempora, Nader Abraham, Ruoyu Zhong, Kaichun Yang, Ke Jin, Ke Li, Min Zhang, Qian Wu, Andrew Barbas, Jean Kwun, Luke P. Lee, Tony Jun Huang, Eileen T. Chambers

{"title":"Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis","authors":"Zhiteng Ma, Riley Kahan, Jianping Xia, Mengxi Wu, Brandon Lu, Emeraghi David, Ye He, Ying Chen, Jessica F. Liu, Mingyuan Liu, Haojun Xu, Linda Stempora, Nader Abraham, Ruoyu Zhong, Kaichun Yang, Ke Jin, Ke Li, Min Zhang, Qian Wu, Andrew Barbas, Jean Kwun, Luke P. Lee, Tony Jun Huang, Eileen T. Chambers","doi":"10.1126/sciadv.ady3262","DOIUrl":"10.1126/sciadv.ady3262","url":null,"abstract":"<div >Antibody-mediated rejection is a leading cause of allograft failure and mortality in pediatric solid organ transplant recipients. Current apheresis systems require large blood volumes and are primarily designed for adults, making them unsuitable for children and small animals. These systems often indiscriminately remove both harmful and protective antibodies, increasing the risk of complications such as life-threatening infections. To address this critical need, we developed acoustofluidic-based system for targeted antibody removal in transplantation (A-START). A-START is engineered to handle small blood volumes and has demonstrated efficacy in preclinical small animal trials. In a sensitized rodent skin transplantation model, A-START only demands 240 microliters of blood, selectively removing donor-specific alloantibodies (DSAs) while preserving protective antibodies, such as tetanus antibodies. A-START retains ~95% of beneficial antibodies and achieves a 60% improvement in DSA removal compared to conventional methods. These findings highlight the transformative potential of A-START as a promising, reliable, scalable solution for improving outcomes in pediatric transplantation and treating antibody-mediated diseases.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady3262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-powered automated model construction for patient-specific CFD simulations of aortic flows 人工智能驱动的自动模型构建，用于特定患者的主动脉流CFD模拟

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adw2825

Pan Du, Delin An, Chaoli Wang, Jian-Xun Wang

{"title":"AI-powered automated model construction for patient-specific CFD simulations of aortic flows","authors":"Pan Du, Delin An, Chaoli Wang, Jian-Xun Wang","doi":"10.1126/sciadv.adw2825","DOIUrl":"10.1126/sciadv.adw2825","url":null,"abstract":"<div >Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and time-consuming, limiting their clinical applications. This study introduces a deep-learning framework that automates the creation of simulation-ready vascular models from medical images. The framework integrates a segmentation module for accurate voxel-based vessel delineation with a surface deformation module that performs anatomically consistent and unsupervised surface refinements guided by medical image data. The integrated pipeline addresses key limitations of existing methods, enhancing geometric accuracy and computational efficiency. Evaluated on public datasets, it achieves state-of-the-art segmentation performance while substantially reducing manual effort and processing time. The resulting vascular models exhibit anatomically accurate and visually realistic geometries, effectively capturing both primary vessels and intricate branching patterns. In conclusion, this work advances the scalability and reliability of image-based computational modeling, facilitating broader applications in clinical and research settings.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw2825","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral edge state control of thermoelectric effects 热电效应的手性边缘状态控制

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.ady9006

William Huynh, Boliang Liu, Simon Munyan, Sina Ahadi, Susanne Stemmer

{"title":"Chiral edge state control of thermoelectric effects","authors":"William Huynh, Boliang Liu, Simon Munyan, Sina Ahadi, Susanne Stemmer","doi":"10.1126/sciadv.ady9006","DOIUrl":"10.1126/sciadv.ady9006","url":null,"abstract":"<div >Thermoelectric responses in two-dimensional electron gases subjected to magnetic fields have the potential to provide unique information about quasiparticle statistics. In this study, we show that chiral edge states play a key role in thermoelectric Hall bar measurements by completely controlling the direction of the internal thermal gradient. To this end, we perform measurements of the magnetothermoelectric responses of cadmium arsenide quantum wells. The magnetothermoelectric responses in the quantum Hall regime agree with theoretical predictions if one considers the role of chiral edge states, which flow in opposite directions on either side of the Hall bar and establish an internal temperature gradient that is perpendicular to the externally applied thermal gradient. We show that the results are self-consistent within this picture under different measurement conditions. We discuss potential applications of the findings, such as in nanoscale control of local temperature gradients and thermoelectric effects along with the characterization of other topological systems with chiral edges states.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady9006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myo-inositol is a key regulator of avian metabolism: From mechanisms to seasonal behavior 肌醇是鸟类代谢的关键调节剂：从机制到季节行为

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adv2794

Adi Domer, Tyler R. Misraje, Dianna Xing, B. Gabriela Arango, Giovanna Selleghin-Veiga, Ammon Corl, Rauri C. K. Bowie, Jimmy A. McGuire, Karen L. Sweazea, José Pablo Vázquez-Medina, Robert Dudley

{"title":"Myo-inositol is a key regulator of avian metabolism: From mechanisms to seasonal behavior","authors":"Adi Domer, Tyler R. Misraje, Dianna Xing, B. Gabriela Arango, Giovanna Selleghin-Veiga, Ammon Corl, Rauri C. K. Bowie, Jimmy A. McGuire, Karen L. Sweazea, José Pablo Vázquez-Medina, Robert Dudley","doi":"10.1126/sciadv.adv2794","DOIUrl":"10.1126/sciadv.adv2794","url":null,"abstract":"<div >Being naturally hyperglycemic and insulin insensitive, birds maintain plasma glucose levels twice as high as mammals of similar size. Recent evidence suggests that perturbation of myo-inositol (MI) plays a role in mammalian hyperglycemic regulation. Using an integrative approach, we identify a fundamental role of MI in avian metabolism. We show that MI transporters are highly conserved across birds and that dietary MI reduces fat accumulation in Anna’s hummingbirds. MI consumption by hummingbirds varies with seasonal changes in body mass, consistent with a regulatory role. Furthermore, MI enhances fatty acid oxidation in avian cells, via effects on pyruvate-dehydrogenase complexes, indicating a role in mitochondrial fuel selection. Our findings underscore the importance of MI in avian metabolism, offering insights into their evolutionary adaptations in the context of insulin insensitivity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv2794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic control of electron correlations in photodoped charge-transfer insulators 光掺杂电荷转移绝缘体中电子相关性的动态控制

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adx5676

Thomas C. Rossi, Nicolas Tancogne-Dejean, Malte Oppermann, Michael Porer, Arnaud Magrez, Rajesh V. Chopdekar, Yayoi Takamura, Urs Staub, Renske M. van der Veen, Angel Rubio, Majed Chergui

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Bone health: Age-related changes in diaphyseal structural properties among European Holocene humans during the last 9000 years 骨骼健康：在过去9000年中，欧洲全新世人类骨干结构特性的年龄相关变化

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-05 DOI: 10.1126/sciadv.adx7981

Vladimír Sládek, Martin Hora, Cara Wall-Scheffler, Michal Struška, Margit Berner

{"title":"Bone health: Age-related changes in diaphyseal structural properties among European Holocene humans during the last 9000 years","authors":"Vladimír Sládek, Martin Hora, Cara Wall-Scheffler, Michal Struška, Margit Berner","doi":"10.1126/sciadv.adx7981","DOIUrl":"10.1126/sciadv.adx7981","url":null,"abstract":"<div >Age-related deterioration in bone strength among Western humans has been linked with sedentary lifestyles, but the effect remains debatable. We evaluated aging of diaphyseal strength and cortical bone loss in a European Holocene sample of 1881 adult humeri, femora, and tibiae. Diaphyseal aging did not differ between Early and Late Holocene adults, despite their differences in physical activity. Adult diaphyseal aging was accompanied by the disproportionate rate between a faster increase in the medullary area and an absent or marginal increase in the total area. This indicates that subperiosteal apposition did not fully biomechanically compensate for the medullary expansion. Diaphyseal strength remained unchanged through age in female femora and male diaphyses but declined in female humeri and tibiae. We highlight the importance of postnatal growth to compensate for adult medullary expansion. Diaphyseal aging is critical for the upper limbs, as humeri are more sensitive to aging than femora and tibiae.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx7981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0