Science Advances最新文献_第8页

Volatility-driven learning in human infants 人类婴儿的波动驱动学习

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adu2014

Francesco Poli, Tommaso Ghilardi, Jana H. M. Bersee, Rogier B. Mars, Sabine Hunnius

{"title":"Volatility-driven learning in human infants","authors":"Francesco Poli, Tommaso Ghilardi, Jana H. M. Bersee, Rogier B. Mars, Sabine Hunnius","doi":"10.1126/sciadv.adu2014","DOIUrl":"10.1126/sciadv.adu2014","url":null,"abstract":"<div >Adapting to change is a fundamental feature of human learning, yet its developmental origins remain elusive. We developed an experimental and computational approach to track infants’ adaptive learning processes via pupil size, an indicator of tonic and phasic noradrenergic activity. We found that 8-month-old infants’ tonic pupil size mirrored trial-by-trial fluctuations in environmental volatility, while phasic pupil responses revealed that infants used this information to dynamically optimize their learning. This adaptive strategy resulted in successful task performance, as evidenced by anticipatory looking toward correct target locations. The ability to estimate volatility varied significantly across infants, and these individual differences were related to infant temperament, indicating early links between cognitive adaptation and emotional responsivity. These findings demonstrate that infants actively adapt to environmental change, and that early differences in this capacity may have profound implications for long-term cognitive and psychosocial development.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu2014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of magma differentiation in optimizing the fluid-assisted extraction of copper to generate large porphyry-type deposits 岩浆分异在优化流体助提铜生成大型斑岩型矿床中的作用

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adr8464

Shunda Yuan, Anthony E. Williams-Jones, Robert J. Bodnar, Panlao Zhao, Zoltán Zajacz, I-Ming Chou, Jingwen Mao

{"title":"The role of magma differentiation in optimizing the fluid-assisted extraction of copper to generate large porphyry-type deposits","authors":"Shunda Yuan, Anthony E. Williams-Jones, Robert J. Bodnar, Panlao Zhao, Zoltán Zajacz, I-Ming Chou, Jingwen Mao","doi":"10.1126/sciadv.adr8464","DOIUrl":"10.1126/sciadv.adr8464","url":null,"abstract":"<div >Porphyry copper deposits (PCDs) are the main source of copper globally, with the metals transported in and deposited from aqueous magmatic fluids. Processes that define the volume of magma and concentration of copper in the magma required to form PCDs, however, are not well understood. Here, we present the results of quantitative modeling of the behavior of Cu and Cl during magma evolution in the upper crust. We show that fractional crystallization is the most important process promoting efficient Cu extraction, and that high concentrations of Cu in the ore-forming hydrothermal fluids can be reached with moderate Cl concentrations. Unusually high concentrations of Cl and Cu in the magma and large magma volumes are not required. Arc magmas of modest volume (<10<sup>3</sup> km<sup>3</sup>) and modest initial Cu and Cl concentrations can generate large PCDs, if a sufficient mass of magmatic fluid is exsolved at an advanced stage of crystallization.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr8464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Widespread presence of bone marrow–like hematopoietic stem cell niche in invertebrate skeletons 骨髓样造血干细胞生态位在无脊椎动物骨骼中的广泛存在

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adw0958

Shanshan Lian, Naina Hu, Xiaomei Chen, Xiaoting Dai, Xuan Zhu, Runyu Qiao, Sinuo Liu, Yuan Lu, Fengmei Zhang, Fengzhi Sun, Zhongqi Pu, Zujing Yang, Runjia Xu, Hao Wang, Liang Zhao, Qiang Xing, Shoujie Li, Wei Wang, Bo Dong, Lingling Zhang, Jingjie Hu, Jing Wang, Zhenmin Bao, Shi Wang

{"title":"Widespread presence of bone marrow–like hematopoietic stem cell niche in invertebrate skeletons","authors":"Shanshan Lian, Naina Hu, Xiaomei Chen, Xiaoting Dai, Xuan Zhu, Runyu Qiao, Sinuo Liu, Yuan Lu, Fengmei Zhang, Fengzhi Sun, Zhongqi Pu, Zujing Yang, Runjia Xu, Hao Wang, Liang Zhao, Qiang Xing, Shoujie Li, Wei Wang, Bo Dong, Lingling Zhang, Jingjie Hu, Jing Wang, Zhenmin Bao, Shi Wang","doi":"10.1126/sciadv.adw0958","DOIUrl":"10.1126/sciadv.adw0958","url":null,"abstract":"<div >Skeletal harboring of hematopoietic stem cells (HSCs) is generally considered as vertebrate-specific innovation during water-to-land transition. However, this long-standing view has not been rigorously evaluated as hematopoietic sites remain poorly understood in most invertebrate groups. We report, to our knowledge, the first discovery of abundant HSCs in adult mollusk shells, an invertebrate hematopoietic niche resembling vertebrate bone marrow (BM). Cell-lineage analysis and functional assays reveal the developmental origin of HSCs during larval shell formation and their participation in hemocyte-mediated shell regeneration and soft-body blood supply. Widespread skeleton-related HSC-like cells are found in diverse invertebrate groups and bony fish group, suggesting skeletons as a universal niche for animal HSCs and HSC-skeleton association preceding vertebrate water-to-land transition. Comparison of invertebrate and vertebrate skeletal HSCs enables the macroevolutionary profiling of a core-set of animal HSC regulators. Our findings would boost fundamental paradigm shifts for hematopoiesis and stem cell research in invertebrates and provide the redefined understanding of vertebrate BM evolution and water-to-land transition.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw0958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics 细胞膜上的外部应变通过膜接触点传递到内质网，改变细胞的能量学

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.ads6132

Ziming Chen, Peilin Chen, Jiayue Li, Euphemie Landao-Bassonga, John Papadimitriou, Junjie Gao, Delin Liu, Andrew Tai, Jinjin Ma, David Lloyd, Brendan F. Kennedy, Ming Hao Zheng

{"title":"External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics","authors":"Ziming Chen, Peilin Chen, Jiayue Li, Euphemie Landao-Bassonga, John Papadimitriou, Junjie Gao, Delin Liu, Andrew Tai, Jinjin Ma, David Lloyd, Brendan F. Kennedy, Ming Hao Zheng","doi":"10.1126/sciadv.ads6132","DOIUrl":"10.1126/sciadv.ads6132","url":null,"abstract":"<div >Mechanotransduction is essential for living cells to adapt to their extracellular environment. However, it is unclear how the biophysical adaptation of intracellular organelles responds to mechanical stress or how these adaptive changes affect cellular homeostasis. Here, using the tendon cell as a mechanosensitive cell type within a bioreactor, we show that the tension of the plasma membrane (PM) and the endoplasmic reticulum (ER) adaptively increases in response to repetitive external stimuli. Depletion of stromal interaction molecule 1 (STIM1), the highest expressed PM-ER tether protein, interfered with mechanotransduction from the PM to the ER, and affected the ER tension. We found that an optimized mechanical strain increased ER tension in a homeostatic manner, but excessive strain resulted in ER expansion, as well as activating ER stress. Last, we showed that changes in ER tension were linked with ER-mitochondria interactions and associated with cellular energetics and function. Together, these findings identify a PM-ER mechanotransduction mechanism that dose-dependently regulates cellular metabolism.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads6132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light field–controlled PHz currents in intrinsic metals 本征金属中的光场控制PHz电流

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adv5406

Beatrix Fehér, Václav Hanus, Weiwei Li, Zsuzsanna Pápa, Judit Budai, Pallabi Paul, Adriana Szeghalmi, Zilong Wang, Matthias F. Kling, Péter Dombi

{"title":"Light field–controlled PHz currents in intrinsic metals","authors":"Beatrix Fehér, Václav Hanus, Weiwei Li, Zsuzsanna Pápa, Judit Budai, Pallabi Paul, Adriana Szeghalmi, Zilong Wang, Matthias F. Kling, Péter Dombi","doi":"10.1126/sciadv.adv5406","DOIUrl":"10.1126/sciadv.adv5406","url":null,"abstract":"<div >Oriented electric currents in metals are routinely driven by applying an external electric potential. Although the response of electrons to the external electric fields occurs within attoseconds, conventional electronics do not use this speed potential. Ultrashort laser pulses with controlled shapes of electric fields that switch direction at petahertz frequencies open perspectives for driving currents in metals. Light field–driven currents were demonstrated in various media including dielectrics, semiconductors, and topological insulators. Now, our research question is whether we can drive and control orders of magnitude more charge carriers in metals enabling ultrafast switching with practically low-energy, picojoule-level pulses. Here, we demonstrate the interaction of light with nanometer-thick metallic layers, which leads to a generation of light field–controlled electric currents. We show that the implantation of metallic layers into a dielectric matrix leads to up to 40 times increase of the sensitivity in contrast to a bare dielectric, decreasing the intensity threshold for lightwave electronics.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv5406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3 心肌细胞衍生的YOD1通过去泛素化和稳定STAT3促进病理性心肌肥大

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adu8422

Bozhi Ye, Wante Lin, Yucheng Jiang, Zhaozheng Zheng, Yanhong Jin, Diyun Xu, Yingjie Liao, Zhihan Jia, Jiaji Chen, Gaojun Wu, Peiren Shan, Guang Liang

{"title":"Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3","authors":"Bozhi Ye, Wante Lin, Yucheng Jiang, Zhaozheng Zheng, Yanhong Jin, Diyun Xu, Yingjie Liao, Zhihan Jia, Jiaji Chen, Gaojun Wu, Peiren Shan, Guang Liang","doi":"10.1126/sciadv.adu8422","DOIUrl":"10.1126/sciadv.adu8422","url":null,"abstract":"<div >Identifying previously unknown targets for pathological cardiac hypertrophy and understanding its mechanisms are crucial. Here, we observed that the deubiquitinating enzyme YOD1 was moderately elevated in human hypertrophic myocardium and mouse models. Cardiomyocyte-specific knockout of YOD1 reduced Ang II– and TAC-induced cardiac hypertrophy. Subsequently, we used multiple proteomic analyses to identify and confirm STAT3 as a substrate protein for YOD1. Mechanistically, our findings revealed that the C155 site of YOD1 removes K48-linked ubiquitin chains from K97 on STAT3, stabilizing STAT3 levels and enhancing its nuclear translocation in cardiomyocytes under Ang II stimulation. Notably, inhibiting STAT3 reversed the antihypertrophic effects of YOD1 deficiency in Ang II–challenged mice. In addition, pharmacological inhibition of YOD1 mitigated Ang II–induced pathological ventricular remodeling in mice. This study clarifies the role of YOD1 and introduces a previously unidentified YOD1-STAT3 axis in regulating pathological cardiac hypertrophy, providing valuable insights for drug development targeting this condition.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu8422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling human crowd dynamics through the foot tracking of pedestrians 通过跟踪行人的脚步来揭示人群动态

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adw2688

Yi Ma, Zhipan Niu, Meng Shi, Wei Xie, Zuoan Hu, Yidong Wei, Tian Zeng, Eric Wai Ming Lee

{"title":"Unraveling human crowd dynamics through the foot tracking of pedestrians","authors":"Yi Ma, Zhipan Niu, Meng Shi, Wei Xie, Zuoan Hu, Yidong Wei, Tian Zeng, Eric Wai Ming Lee","doi":"10.1126/sciadv.adw2688","DOIUrl":"10.1126/sciadv.adw2688","url":null,"abstract":"<div >Movement of pedestrian crowds is ubiquitous in human society. However, it is unclear what dynamical regimes pedestrian crowds can exhibit at different crowd densities, how pedestrians move in these different dynamical regimes, and in which dynamical regime the movement synchronization of pedestrians is most likely to occur. Here, we conducted a unidirectional crowd movement experiment, in which we tracked the movement of pedestrian crowds through foot tracking. We find experimentally that pedestrian crowds can exhibit three distinct dynamical regimes (free regime, slow-moving regime, and jammed regime) depending on the crowd density. In the free regime, pedestrians’ movement is not constrained; in the slow-moving regime, pedestrians’ speed is constrained, but pedestrians’ movement direction in each step is not influenced; and in the jammed regime, both pedestrians’ speed and movement direction in each step are constrained. We also demonstrate that pedestrians are most likely to synchronize their movements spontaneously at the onset of jamming. Our findings provide important insights into crowd dynamics.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw2688","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Headward incision of large rivers in response to glacial sea level fall 由于冰川海平面下降，大河向上游切割

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adr5446

Zhongping Lai, Yuexin Liu, Ziyuan Wu, Yantian Xu, Zibin Fang, David R. Montgomery

引用次数: 0

Earliest evidence of rice cultivation in Remote Oceania: Ritual use by the first islanders in the Marianas 3500 years ago 遥远的大洋洲最早的水稻种植证据：3500年前马里亚纳群岛第一批岛民的仪式使用

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adw3591

Mike T. Carson, Weiwei Wang, Xiujia Huan, Siqi Dong, Hsiao-chun Hung, Zhenhua Deng

{"title":"Earliest evidence of rice cultivation in Remote Oceania: Ritual use by the first islanders in the Marianas 3500 years ago","authors":"Mike T. Carson, Weiwei Wang, Xiujia Huan, Siqi Dong, Hsiao-chun Hung, Zhenhua Deng","doi":"10.1126/sciadv.adw3591","DOIUrl":"10.1126/sciadv.adw3591","url":null,"abstract":"<div >Rice was a staple crop in the ancestral Austronesian regions of Taiwan and Island Southeast Asia, but it was unknown in any of the Pacific Islands at the time of European encounters, with the exception of the unique case of Guam and the Mariana Islands. Through multiple methodologies, including phytolith analysis, micro–computed tomography scanning, and thin-section petrography, this recent research confirms the presence of abundant rice husk and leaf phytoliths adhering to red-slipped pottery (“Marianas Red”) at the Ritidian Site Complex in Guam, dated by radiocarbon to 3500 to 3100 years ago. This study addresses the long-standing question of whether the first Pacific Islanders transported rice with them from the Philippines across 2300 kilometers of open sea, representing the longest known ocean voyage of the time. During this early period, rice was restricted to special ritual events in the Marianas. The early voyage apparently was planned with provisions of rice at 3500 years ago.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw3591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro and in vivo evaluation of chemically synthesized, receptor-biased interleukin-4 and photocaged variants 体外和体内评价化学合成，受体偏向的白介素-4和光笼子变异

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-25 DOI: 10.1126/sciadv.adw9755

Mamiko Ninomiya, Cecilie Egholm, Daniel Breu, Onur Boyman, Jeffrey W. Bode

{"title":"In vitro and in vivo evaluation of chemically synthesized, receptor-biased interleukin-4 and photocaged variants","authors":"Mamiko Ninomiya, Cecilie Egholm, Daniel Breu, Onur Boyman, Jeffrey W. Bode","doi":"10.1126/sciadv.adw9755","DOIUrl":"10.1126/sciadv.adw9755","url":null,"abstract":"<div >Interleukin-4 (IL-4) plays a central role in type 2 immune responses. Despite its potential use for allergic and autoimmune diseases, its pleiotropic receptor binding complicates selective targeting of IL-4 signaling pathways. We developed a chemical synthesis of (i) IL-4 variants with atomically tailored side-chain modifications that deter specific receptor interactions and (ii) conditionally activatable IL-4 variants uncaged with 365-nanometer light. In primary cell studies, different variants elicited selective STAT5 or STAT6 phosphorylation in lymphocytes or neutrophils. In murine studies, photocaged IL-4 suppressed inflammation only upon UV irradiation, demonstrating precise on demand control. We accomplished the synthesis and folding of IL-4, a hydrophobic cytokine with three disulfide bonds, using the alpha-ketoacid–hydroxylamine (KAHA) ligation to assemble three segments. We introduced further conjugations, including PEGylation for half-life extension, through orthogonal ligations enabled by functionalized amino acid building blocks. This work highlights the flexibility of chemical protein synthesis to produce therapeutically valuable cytokines, including receptor-biased and spatiotemporally activatable IL-4 variants.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw9755","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0