Science Advances最新文献_第7页

In situ evidence for serpentinization within the Máaz formation, Jezero crater, Mars 火星耶泽洛陨石坑Máaz地层内蛇纹石化的现场证据

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adr8793

Nicholas J. Tosca, Michael M. Tice, Joel A. Hurowitz, David A. K. Pedersen, Jesper Henneke, Lucia Mandon, Francis M. McCubbin, Oliver Ross, Po-Yen Tung, Richard J. Harrison, An Li, Mariek E. Schmidt, Tanya V. Kizovski, Yang Liu, Lisa Mayhew, Michael W. M. Jones, Josh Labrie, Scott Davidoff, Abigail C. Allwood, Olivier Beyssac, Adrian Brown, Morgan Cable, Jade Comellas, Benton C. Clark, Adrian E. Galvin, Briony Horgan, Christopher M. Heirwegh, Peter Nemere, Brendan J. Orenstein, Cathy Quantin-Nataf, Clément Royer, Allan Treiman, Lawrence A. Wade, Roger Wiens, Austin P. Wright

{"title":"In situ evidence for serpentinization within the Máaz formation, Jezero crater, Mars","authors":"Nicholas J. Tosca, Michael M. Tice, Joel A. Hurowitz, David A. K. Pedersen, Jesper Henneke, Lucia Mandon, Francis M. McCubbin, Oliver Ross, Po-Yen Tung, Richard J. Harrison, An Li, Mariek E. Schmidt, Tanya V. Kizovski, Yang Liu, Lisa Mayhew, Michael W. M. Jones, Josh Labrie, Scott Davidoff, Abigail C. Allwood, Olivier Beyssac, Adrian Brown, Morgan Cable, Jade Comellas, Benton C. Clark, Adrian E. Galvin, Briony Horgan, Christopher M. Heirwegh, Peter Nemere, Brendan J. Orenstein, Cathy Quantin-Nataf, Clément Royer, Allan Treiman, Lawrence A. Wade, Roger Wiens, Austin P. Wright","doi":"10.1126/sciadv.adr8793","DOIUrl":"10.1126/sciadv.adr8793","url":null,"abstract":"<div >As both a source of atmospheric H<sub>2</sub> and a sink for liquid water, the serpentinization of olivine-bearing rocks is widely thought to have influenced the long-term evolution of the early martian atmosphere and hydrosphere. However, the mechanisms, timing, and global importance of this process are unconstrained, in part because the remnants of ancient serpentinizing systems have not been examined in situ. New geochemical and mineralogical data from multiple instruments aboard the Mars 2020 Perseverance rover record serpentinization and associated H<sub>2</sub> production in ancient igneous rocks of the Máaz formation, exposed on the Jezero crater floor. These data, combined with petrogenetic constraints, indicate that serpentinization may have been driven by devolatilization of magmatic H<sub>2</sub>O, highlighting a potential link between H<sub>2</sub> production and the style and tempo of magmatism within the ancient martian crust.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr8793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Universal dimensions of visual representation 视觉表现的普遍维度

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adw7697

Zirui Chen, Michael F. Bonner

{"title":"Universal dimensions of visual representation","authors":"Zirui Chen, Michael F. Bonner","doi":"10.1126/sciadv.adw7697","DOIUrl":"10.1126/sciadv.adw7697","url":null,"abstract":"<div >Do visual neural networks learn brain-aligned representations because they share architectural constraints and task objectives with biological vision or because they share universal features of natural image processing? We characterized the universality of hundreds of thousands of representational dimensions from networks with different architectures, tasks, and training data. We found that diverse networks learn to represent natural images using a shared set of latent dimensions, despite having highly distinct designs. Next, by comparing these networks with human brain representations measured with functional magnetic resonance imaging, we found that the most brain-aligned representations in neural networks are those that are universal and independent of a network’s specific characteristics. Each network can be reduced to fewer than 10 of its most universal dimensions with little impact on its representational similarity to the brain. These results suggest that the underlying similarities between artificial and biological vision are primarily governed by a core set of universal representations that are convergently learned by diverse systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell analysis of the decidua unveils the mechanism of anti-inflammatory exosomes for chorioamnionitis in nonhuman primates 蜕膜的单细胞分析揭示了非人类灵长类动物绒毛膜羊膜炎的抗炎外泌体机制

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adp0467

Seung Hyun Jang, Hojun Choi, Eun Mi Lee, Seung-Bin Yoon, Hye-Jung Kim, Cheolhyoung Park, Jae Kyung Won, Seung Han Shin, Ji-Su Kim, Chan-Wook Park, Heon Yung Gee, Chulhee Choi

{"title":"Single-cell analysis of the decidua unveils the mechanism of anti-inflammatory exosomes for chorioamnionitis in nonhuman primates","authors":"Seung Hyun Jang, Hojun Choi, Eun Mi Lee, Seung-Bin Yoon, Hye-Jung Kim, Cheolhyoung Park, Jae Kyung Won, Seung Han Shin, Ji-Su Kim, Chan-Wook Park, Heon Yung Gee, Chulhee Choi","doi":"10.1126/sciadv.adp0467","DOIUrl":"10.1126/sciadv.adp0467","url":null,"abstract":"<div >The effectiveness of exosomes engineered to carry a dominantly active variant of inhibitor α of nuclear factor κB (NF-κB) (IκBα), super-repressor IκB (srIκB), that inhibits the expression of NF-κB in various animal models of inflammatory diseases has been demonstrated. In this study, we used a lipopolysaccharide (LPS)–induced chorioamnionitis model in pregnant nonhuman primates to explore the therapeutic potential and mode of action of srIκB-loaded exosomes (Exo-srIκBs). Intraamniotic injection of LPS induced infiltration of BCL2A1-positive neutrophils and CD68-positive macrophages in the extraplacental membranes, causing fetal lung injury. Conversely, administration of Exo-srIκB via intraamniotic and intravenous routes (6.9 × 10<sup>10</sup> and 4 × 10<sup>11</sup> particle numbers, respectively) ameliorated these effects. Single-cell RNA sequencing of the decidua and bulk RNA sequencing of the choriodecidua highlighted that Exo-srIκB treatment mitigated LPS-induced inflammatory pathways, particularly in macrophages, leading to a cascade effect on neutrophils through NF-κB signaling inhibition. These findings underscore the potential of Exo-srIκB as a therapeutic strategy for chorioamnionitis.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp0467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2 ppe71 -esx - esxy - ppe38位点的缺失驱动结核分枝杆菌谱系的适应性转录反应和高毒力2

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adw5194

Benjamin Koleske, Courtney Schill, Saranathan Rajagopalan, Somnath Shee, Yazmin B. Martinez-Martinez, Manish Gupta, Jessica Shen, William R. Jacobs Jr., William R. Bishai

{"title":"Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2","authors":"Benjamin Koleske, Courtney Schill, Saranathan Rajagopalan, Somnath Shee, Yazmin B. Martinez-Martinez, Manish Gupta, Jessica Shen, William R. Jacobs Jr., William R. Bishai","doi":"10.1126/sciadv.adw5194","DOIUrl":"10.1126/sciadv.adw5194","url":null,"abstract":"<div ><i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) is remarkable for its immense global disease burden and low mutation rate. Despite strong selective pressure, <i>M.tb</i> shows frequent deletions at the <i>PPE71</i>–<i>38</i> locus, most notably in hypervirulent L2 Beijing strains. Here, we show that loss of the <i>PPE71</i>–<i>38</i> locus causes increased stress response gene expression and increased triglyceride levels. In addition, we demonstrate that reintroduction of <i>PPE71</i> into the L2 strain HN878 suppresses the baseline elevation of these transcripts, while overexpression of <i>PPE71</i> increases the localization of PE_PGRS proteins and lipoproteins to the <i>M.tb</i> outer mycomembrane. Mouse infection confirmed the hypervirulence of the <i>PPE71</i>–<i>38</i> deletion strain and conversely showed that <i>PPE71</i> overexpression attenuates <i>M.tb</i>. Our results indicate that loss of <i>PPE71</i>–<i>38</i> is sufficient to drive an adaptive transcriptional response seen in <i>M.tb</i> L2 strains that likely contributes to the hypervirulence of this lineage.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw5194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast and robust visual object recognition in young children 快速鲁棒的幼儿视觉物体识别

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.ads6821

Vladislav Ayzenberg, Sukran Bahar Sener, Kylee Novick, Stella F. Lourenco

引用次数: 0

LHX2 regulates dendritic morphogenesis in layer II/III neurons of the neocortex LHX2调节新皮层II/III层神经元的树突形态发生

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.ado1384

Mahima Bose, Sreenath Ravindran, Sanjna Kumari, Achintya Srivastava, Archana Iyer, Binita Vedak, Ishita Talwar, Rishikesh Narayanan, Shubha Tole

{"title":"LHX2 regulates dendritic morphogenesis in layer II/III neurons of the neocortex","authors":"Mahima Bose, Sreenath Ravindran, Sanjna Kumari, Achintya Srivastava, Archana Iyer, Binita Vedak, Ishita Talwar, Rishikesh Narayanan, Shubha Tole","doi":"10.1126/sciadv.ado1384","DOIUrl":"10.1126/sciadv.ado1384","url":null,"abstract":"<div >In the mammalian neocortex, the two hemispheres communicate via the corpus callosum. We investigated mechanisms regulating dendritic arbors and spines of callosal neurons. The transcription factor LIM Homeodomain 2 (<i>Lhx2</i>), a key regulator of cortical development, is expressed in postmitotic layer II/III neurons and their progenitors. Loss of <i>Lhx2</i> in either population caused similar but distinct phenotypes: reduced dendritic arbors, altered spine morphology, and changed electrophysiological properties. Morphometric defects were more severe when <i>Lhx2</i> was disrupted in progenitors and were recapitulated by its specific loss in basal progenitors. <i>Lhx2</i> loss in progenitors aberrantly up-regulated <i>Neurog2</i> in postmitotic neurons, and <i>Neurog2</i> knockdown partially rescued the phenotype. Loss of <i>Lhx2</i> at either stage also up-regulated Wnt signaling pathway genes. The mutant phenotype was mimicked by constitutive activation of β-CATENIN in postmitotic neurons. Our findings reveal previously unidentified LHX2-dependent mechanisms of dendritic morphogenesis, highlighting its temporally dynamic and diverse roles in neocortical development.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ado1384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnesium microspheres for enhanced transarterial chemoembolization therapy of hepatocellular carcinoma: From animal models to a pilot clinical study 镁微球增强肝细胞癌经动脉化疗栓塞治疗：从动物模型到初步临床研究

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adv0885

Fei Gong, Liyun Zheng, Jiachen Xu, Yumin Wu, Qiutong Jin, Jiaqi Lu, Zifan Pei, Zhongwei Zhao, Minjiang Chen, Jianfei Tu, Shiji Fang, Weiqian Chen, Kailu Wei, Nailin Yang, Chuntao Gong, Fazong Wu, Yeyu Zhang, Caifang Ni, Liang Cheng, Zhuang Liu, Jiansong Ji

{"title":"Magnesium microspheres for enhanced transarterial chemoembolization therapy of hepatocellular carcinoma: From animal models to a pilot clinical study","authors":"Fei Gong, Liyun Zheng, Jiachen Xu, Yumin Wu, Qiutong Jin, Jiaqi Lu, Zifan Pei, Zhongwei Zhao, Minjiang Chen, Jianfei Tu, Shiji Fang, Weiqian Chen, Kailu Wei, Nailin Yang, Chuntao Gong, Fazong Wu, Yeyu Zhang, Caifang Ni, Liang Cheng, Zhuang Liu, Jiansong Ji","doi":"10.1126/sciadv.adv0885","DOIUrl":"10.1126/sciadv.adv0885","url":null,"abstract":"<div >Transarterial chemoembolization (TACE) has been extensively used in clinic to treat unresectable hepatocellular carcinoma (HCC). Herein, magnesium microspheres (Mg MSs) were used as embolic devices to enhance lipiodol-mediated TACE. After being dispersed in lipiodol and injected into tumors, Mg MSs would continuously generate hydrogen and magnesium hydroxide, which could neutralize the acidic tumor microenvironment, restore exhausted CD8<sup>+</sup> T cells, reverse immunosuppression, and trigger specific T cell–mediated antitumor responses, synergistically resulting in inhibited tumor growth. As demonstrated in a rabbit orthotopic liver cancer model, artery infusion of Mg MS–dispersed lipiodol offered greatly enhanced therapeutic outcome compared to lipiodol-based or polymeric-bead–based TACE. In a pilot clinical study, among 15 eligible patients with HCC, 11 patients achieved complete response and 3 patients achieved partial responses without unexpected treatment-related adverse events during the 1 to 3 months’ follow-up. The objective response rate of Mg-enhanced TACE was ~93.3% in this small-scale trial, much higher than that of current TACE therapies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv0885","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient and wavelength-tunable second-harmonic generation toward the green gap 面向绿隙的高效波长可调谐二次谐波产生

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adw2781

Zhiquan Yuan, Jinhao Ge, Peng Liu, Bohan Li, Mingxiao Li, Jin-Yu Liu, Yan Yu, Hao-Jing Chen, John Bowers, Kerry Vahala

{"title":"Efficient and wavelength-tunable second-harmonic generation toward the green gap","authors":"Zhiquan Yuan, Jinhao Ge, Peng Liu, Bohan Li, Mingxiao Li, Jin-Yu Liu, Yan Yu, Hao-Jing Chen, John Bowers, Kerry Vahala","doi":"10.1126/sciadv.adw2781","DOIUrl":"10.1126/sciadv.adw2781","url":null,"abstract":"<div >Achieving compact and efficient visible laser sources is crucial for a wide range of applications. However, traditional semiconductor laser technology faces difficulties in producing high-brightness green light, leaving a “green gap” in wavelength coverage. Second-harmonic generation (SHG) offers a promising alternative by converting near-infrared sources to visible wavelengths with high efficiency and spectral purity. Here, we demonstrate efficient and tunable SHG within the green spectrum using a high-<i>Q</i> Si<sub>3</sub>N<sub>4</sub> microresonator. On-chip green power as high as 5.3 milliwatts is generated with a conversion efficiency of 141% per watt (absolute 7.9%). A space-charge grating induced by the photogalvanic effect realizes reconfigurable grating numbers and flexible wavelength tuning over a range of 2.6 terahertz. In addition, grating formation dynamics and competition are observed. These findings underscore the potential of Si<sub>3</sub>N<sub>4</sub> as a robust, integrative platform for on-chip, tunable green light sources.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw2781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous two-color imaging with a dual-channel miniscope in freely behaving mice 用双通道显微镜同时对行为自由的小鼠进行双色成像

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adr6470

Zhe Dong, Yu Feng, Keziah Diego, Austin M. Baggetta, Brian M. Sweis, Zachary T. Pennington, Sophia I. Lamsifer, Yosif Zaki, Federico Sangiuliano, Paul A. Philipsberg, Denisse Morales-Rodriguez, Daniel Kircher, Paul Slesinger, Tristan Shuman, Daniel Aharoni, Denise J. Cai

{"title":"Simultaneous two-color imaging with a dual-channel miniscope in freely behaving mice","authors":"Zhe Dong, Yu Feng, Keziah Diego, Austin M. Baggetta, Brian M. Sweis, Zachary T. Pennington, Sophia I. Lamsifer, Yosif Zaki, Federico Sangiuliano, Paul A. Philipsberg, Denisse Morales-Rodriguez, Daniel Kircher, Paul Slesinger, Tristan Shuman, Daniel Aharoni, Denise J. Cai","doi":"10.1126/sciadv.adr6470","DOIUrl":"10.1126/sciadv.adr6470","url":null,"abstract":"<div >Miniaturized fluorescence microscopes (miniscopes) enable imaging of calcium events from a large population of neurons in freely behaving animals. Traditionally, miniscopes have only been able to record from a single fluorescence wavelength. Here, we present an open-source dual-channel miniscope that simultaneously records two wavelengths in freely behaving animals. To enable simultaneous acquisition of two fluorescent wavelengths, we incorporated two CMOS sensors into a single miniscope. To validate our dual-channel miniscope, we imaged hippocampal CA1 region that co-expressed a dynamic calcium indicator (GCaMP) and a static nuclear signal (dTomato) while mice ran on a linear track. Our results suggest that, even when neurons were registered across days using dTomato signals, hippocampal spatial coding changes over time. In conclusion, our dual-channel miniscope enables imaging of two fluorescence wavelengths with minimal cross-talk between the two channels, opening the doors to a multitude of previously inaccessible experimental possibilities.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr6470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-inorganic metafabric scintillators for conformally flexible and wearable x-ray detection and imaging 用于保形柔性和可穿戴x射线探测和成像的全无机超织物闪烁体

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-06-27

Li Xu, Peng Ran, Wenqian Zhou, Yu Jia, Jianyong Yu, Yang (Michael) Yang, Yang Si

{"title":"All-inorganic metafabric scintillators for conformally flexible and wearable x-ray detection and imaging","authors":"Li Xu, Peng Ran, Wenqian Zhou, Yu Jia, Jianyong Yu, Yang (Michael) Yang, Yang Si","doi":"","DOIUrl":"","url":null,"abstract":"<div >Traditional scintillators rely on rigid inorganic matrices with high-<i>Z</i> elements, whose mechanical inflexibility restricts applications in multiple scenarios. Developing an efficient scintillator that combines inorganic properties with flexibility is a desirable yet highly challenging goal. We pioneered an inorganic metafabric scintillator paradigm through self-sustained slip system engineering, transforming brittle all-inorganic scintillation materials into ductile textile architectures, yielding intrinsically conformally flexible scintillators that adhere seamlessly to complex, curved surfaces. The ultimate all-inorganic scintillator delivers near-unity quantum yield, with scintillation output more than 10 times higher than that of previous polymer matrix–based flexible scintillators. Using these metafabric scintillators, a multimodal x-ray interactive wearable platform (X-Wear) was developed, and their applications in body-centered flexible detection and imaging, mobile health, visual radiation monitoring, and breathable radiation shielding were successfully demonstrated. This work offers a previously undefined paradigm for a scintillator system design strategy that maintains the high performance of inorganic scintillators while adding the functionality of being conformally flexible and wearable of fabrics.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv5537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0