Science Advances最新文献_第7页

Synthesis of Ti4Au3C3 and its derivative trilayer goldene through chemical exfoliation

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adt7999

Yuchen Shi, Shun Kashiwaya, Jun Lu, Martin Dahlqvist, Davide G. Sangiovanni, Vladyslav Rogoz, Martin Magnuson, Grzegorz Greczynski, Mike Andersson, Johanna Rosen, Lars Hultman

{"title":"Synthesis of Ti4Au3C3 and its derivative trilayer goldene through chemical exfoliation","authors":"Yuchen Shi, Shun Kashiwaya, Jun Lu, Martin Dahlqvist, Davide G. Sangiovanni, Vladyslav Rogoz, Martin Magnuson, Grzegorz Greczynski, Mike Andersson, Johanna Rosen, Lars Hultman","doi":"10.1126/sciadv.adt7999","DOIUrl":"10.1126/sciadv.adt7999","url":null,"abstract":"<div >Achieving large two-dimensional (2D) sheets of any metal is challenging due to their tendency to coalescence or cluster into 3D shapes. Recently, single-atom-thick gold sheets, termed goldene, was reported. Here, we ask if goldene can be extended to include multiple layers. The answer is yes, and trilayer goldene is the magic number, for reasons of electronegativity. Experiments are made to synthesize the atomically laminated phase Ti<sub>4</sub>Au<sub>3</sub>C<sub>3</sub> through substitutional intercalation of Si layers in Ti<sub>4</sub>SiC<sub>3</sub> for Au. Density functional theory calculations suggest that it is energetically favorable to insert three layers of Au into Ti<sub>4</sub>SiC<sub>3</sub>, compared to inserting a monolayer, a bilayer, or more than three layers. Isolated trilayer goldene sheets, ~100 nanometers wide and 6.7 angstroms thick, were obtained by chemically etching the Ti<sub>4</sub>C<sub>3</sub> layers from Ti<sub>4</sub>Au<sub>3</sub>C<sub>3</sub> templates. Furthermore, trilayer goldene is found in both <i>hcp</i> and <i>fcc</i> forms, where the <i>hcp</i> is ~50 milli–electron volts per atom more stable at room temperature from ab initio molecular dynamic simulations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt7999","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.ads4441

Kasey L. Brida, Emily T. Jorgensen, Robert A. Phillips III, Catherine E. Newman, Jennifer J. Tuscher, Emily K. Morring, Morgan E. Zipperly, Lara Ianov, Kelsey D. Montgomery, Madhavi Tippani, Thomas M. Hyde, Kristen R. Maynard, Keri Martinowich, Jeremy J. Day

{"title":"Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward","authors":"Kasey L. Brida, Emily T. Jorgensen, Robert A. Phillips III, Catherine E. Newman, Jennifer J. Tuscher, Emily K. Morring, Morgan E. Zipperly, Lara Ianov, Kelsey D. Montgomery, Madhavi Tippani, Thomas M. Hyde, Kristen R. Maynard, Keri Martinowich, Jeremy J. Day","doi":"10.1126/sciadv.ads4441","DOIUrl":"10.1126/sciadv.ads4441","url":null,"abstract":"<div >Drugs of abuse activate defined neuronal populations in reward structures such as the nucleus accumbens (NAc), which promote the enduring synaptic, circuit, and behavioral consequences of drug exposure. While the molecular and cellular effects arising from experience with drugs like cocaine are increasingly well understood, mechanisms that dictate NAc neuronal recruitment remain unknown. Here, we leveraged unbiased single-nucleus transcriptional profiling and targeted in situ detection to identify <i>Reln</i> (encoding the secreted glycoprotein, Reelin) as a marker of cocaine-activated neuronal populations within the rat NAc. A CRISPR interference approach enabling selective <i>Reln</i> knockdown in the adult NAc altered expression of calcium signaling genes, promoted a transcriptional trajectory consistent with loss of cocaine sensitivity, and decreased MSN excitability. Behaviorally, <i>Reln</i> knockdown prevented cocaine locomotor sensitization, abolished cocaine place preference memory, and decreased cocaine self-administration behavior. These results identify Reelin as a critical mechanistic link between neuronal activation and cocaine-induced behavioral adaptations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads4441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilization

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adp5782

Samuel Petshow, Azariah Coblentz, Andrew M. Hamilton, Dipannita Sarkar, Margarita Anisimova, Juan C. Flores, Karen Zito

{"title":"Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilization","authors":"Samuel Petshow, Azariah Coblentz, Andrew M. Hamilton, Dipannita Sarkar, Margarita Anisimova, Juan C. Flores, Karen Zito","doi":"10.1126/sciadv.adp5782","DOIUrl":"10.1126/sciadv.adp5782","url":null,"abstract":"<div >Synaptic Rho guanosine triphosphatase (GTPase) guanine nucleotide exchange factors (RhoGEFs) play vital roles in regulating the activity-dependent neuronal plasticity that is critical for learning. Ephexin5, a RhoGEF implicated in the etiology of Alzheimer’s disease and Angelman syndrome, was originally reported in neurons as a RhoA-specific GEF that negatively regulates spine synapse density. Here, we show that Ephexin5 activates both RhoA and Cdc42 in the brain. Furthermore, using live imaging of GTPase biosensors, we demonstrate that Ephexin5 regulates activity-dependent Cdc42, but not RhoA, signaling at single synapses. The selectivity of Ephexin5 for Cdc42 activation is regulated by tyrosine phosphorylation, which is regulated by neuronal activity. Last, in contrast to Ephexin5’s role in negatively regulating synapse density, we show that, downstream of neuronal activity, Ephexin5 positively regulates synaptic growth and stabilization. Our results support a model in which plasticity-inducing neuronal activity regulates Ephexin5 tyrosine phosphorylation, driving Ephexin5-mediated activation of Cdc42 and the spine structural growth and stabilization vital for learning.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp5782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrabright difuranfluoreno-dithiophen polymers for enhanced afterglow imaging of atherosclerotic plaques

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.ads4646

Zhe Li, Hui Cao, Youjuan Wang, Shiyi Liao, Xu Li, Baode Chen, Xiaosha Wang, Lihui Jiang, Yingping Zou, Xiao-bing Zhang, Guosheng Song

{"title":"Ultrabright difuranfluoreno-dithiophen polymers for enhanced afterglow imaging of atherosclerotic plaques","authors":"Zhe Li, Hui Cao, Youjuan Wang, Shiyi Liao, Xu Li, Baode Chen, Xiaosha Wang, Lihui Jiang, Yingping Zou, Xiao-bing Zhang, Guosheng Song","doi":"10.1126/sciadv.ads4646","DOIUrl":"10.1126/sciadv.ads4646","url":null,"abstract":"<div >Cardiovascular diseases, including stroke driven by atherosclerosis, remain a leading global health concern. Current diagnostic imaging modalities such as magnetic resonance imaging fail to characterize oxidative stress within atherosclerotic plaques. Here, we introduce difuranfluoreno-dithiophen–based polymers designed for afterglow imaging, offering ultrabright luminescence, ultralow-power excitation (0.087 milliwatts per square centimeter), and ultrashort acquisition times (0.01 seconds). Through a molecular engineering strategy, we have optimized polymers for enhanced reactive oxygen species (ROS) generation capability, ROS capturing capability, and fluorescence quantum yield, resulting in an increase in afterglow intensity (~130-fold) compared to commonly used 2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylenevinylene polymer (MEHPPV). Additionally, we have developed ratiometric afterglow nanoparticles doped with oxidative stress–responsive molecules, enabling imaging of oxidative stress markers in atherosclerotic plaque. This approach provides a tool for cardiovascular imaging and diagnostics, which is conducive to the auxiliary diagnosis and risk stratification of atherosclerosis.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads4646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stealth and deception: Adaptive motion camouflage in hunting broadclub cuttlefish

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adr3686

Matteo Santon, Jolyon Troscianko, Charlie D. Heatubun, Martin J. How

引用次数: 0

NAT10 and N4-acetylcytidine restrain R-loop levels and related inflammatory responses

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.ads6144

Turja K. Debnath, Nathan S. Abell, Yi-Ru Li, Sravan K. Devanathan, Enrique Navedo, Blerta Xhemalçe

{"title":"NAT10 and N4-acetylcytidine restrain R-loop levels and related inflammatory responses","authors":"Turja K. Debnath, Nathan S. Abell, Yi-Ru Li, Sravan K. Devanathan, Enrique Navedo, Blerta Xhemalçe","doi":"10.1126/sciadv.ads6144","DOIUrl":"10.1126/sciadv.ads6144","url":null,"abstract":"<div ><i>N</i><sup>4</sup>-acetylcytidine (ac<sup>4</sup>C) is deposited on diverse RNAs by <i>N</i>-acetyltransferase 10 (NAT10), a protein with high biological relevance for aging and cancer. We performed a comprehensive survey of ac<sup>4</sup>C using metabolic labeling, sodium cyanoborohydride chemical treatment coupled to next-generation sequencing (NGS), and ac<sup>4</sup>C antibody–based cell and molecular biology techniques. Our analysis shows that NAT10-dependent ac<sup>4</sup>C-acetylation is robust in rRNA and specific tRNAs but low/spurious in mRNA. It also revealed an inflammatory signature and mutagenesis at transcriptionally active sites in NAT10-KO cells. This finding led us to explore the role of NAT10 in R-loops, which were recently linked to APOBEC3B-mediated mutagenesis. Our analysis showed that R-loops are ac<sup>4</sup>C-acetylated in a NAT10-dependent manner. Furthermore, NAT10 restrains the levels of R-loops at a subset of differentially expressed genes in a catalytic activity–dependent manner. Together with cellular biology data showing ac<sup>4</sup>C-modified RNA in endosomal structures, we propose that increased levels of ac<sup>4</sup>C-unmodified RNAs, likely derived from R-loops, in endosomal structures induce inflammatory responses.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads6144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring microvascular changes over time with a repositionable 3D ultrasonic capacitive micromachined row-column sensor

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adr6449

Cyprien Blanquart, Léa Davenet, Julien Claisse, Mallorie Giroud, Audren Boulmé, Edgard Jeanne, Mickaël Tanter, Mafalda Correia, Thomas Deffieux

{"title":"Monitoring microvascular changes over time with a repositionable 3D ultrasonic capacitive micromachined row-column sensor","authors":"Cyprien Blanquart, Léa Davenet, Julien Claisse, Mallorie Giroud, Audren Boulmé, Edgard Jeanne, Mickaël Tanter, Mafalda Correia, Thomas Deffieux","doi":"10.1126/sciadv.adr6449","DOIUrl":"10.1126/sciadv.adr6449","url":null,"abstract":"<div >eHealth devices, including smartwatches and smart scales, have the potential to transform health care by enabling continuous, real-time monitoring of vital signs over extended periods. Existing technologies, however, lack comprehensive monitoring of the microvascular network, which is linked to conditions such as diabetes, hypertension, and small vessel diseases. This study introduces an ultrasound approach using a capacitive micromachined ultrasound transducer row-column array for continuous, ultrasensitive three-dimensional (3D) Doppler imaging of microvascular changes such as hemodynamic variations or vascular remodeling. In vitro tests and in vivo studies with healthy volunteers demonstrated the sensor’s ability to image the 3D microvascular network at high resolution over different timescales with automatic registration and to detect microvascular changes with high sensitivity. Integrating this technology into wearable devices could, one day, enhance understanding, monitoring, and possibly early detection of microvascular-related health conditions.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr6449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin-interfaced multimodal sensing and tactile feedback system as enhanced human-machine interface for closed-loop drone control

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adt6041

Chunki Yiu, Yiming Liu, Wooyoung Park, Jian Li, Xingcan Huang, Kuanming Yao, Yuyu Gao, Guangyao Zhao, Hongwei Chu, Jingkun Zhou, Dengfeng Li, Hu Li, Binbin Zhang, Lung Chow, Ya Huang, Qingsong Xu, Xinge Yu

{"title":"Skin-interfaced multimodal sensing and tactile feedback system as enhanced human-machine interface for closed-loop drone control","authors":"Chunki Yiu, Yiming Liu, Wooyoung Park, Jian Li, Xingcan Huang, Kuanming Yao, Yuyu Gao, Guangyao Zhao, Hongwei Chu, Jingkun Zhou, Dengfeng Li, Hu Li, Binbin Zhang, Lung Chow, Ya Huang, Qingsong Xu, Xinge Yu","doi":"10.1126/sciadv.adt6041","DOIUrl":"10.1126/sciadv.adt6041","url":null,"abstract":"<div >Unmanned aerial vehicles have undergone substantial development and market growth recently. With research focusing on improving control strategies for better user experience, feedback systems, which are vital for operator awareness of surroundings and flight status, remain underdeveloped. Current bulky manipulators also hinder accuracy and usability. Here, we present an enhanced human-machine interface based on skin-integrated multimodal sensing and feedback devices for closed-loop drone control. This system captures hand gestures for intuitive, rapid, and precise control. An integrated tactile actuator array translates the drone’s posture into two-dimensional tactile information, enhancing the operator’s perception of the flight situation. Integrated obstacle detection and neuromuscular electrical stimulation–based force feedback system enable collision avoidance and flight path correction. This closed-loop system combines intuitive controls and multimodal feedback to reduce training time and cognitive load while improving flight stability, environmental awareness, and the drone’s posture. The use of stretchable electronics also addresses wearability and bulkiness issues in traditional systems, advancing human-machine interface design.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt6041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning the rules of peptide self-assembly through data mining with large language models

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adv1971

Zhenze Yang, Sarah K. Yorke, Tuomas P. J. Knowles, Markus J. Buehler

{"title":"Learning the rules of peptide self-assembly through data mining with large language models","authors":"Zhenze Yang, Sarah K. Yorke, Tuomas P. J. Knowles, Markus J. Buehler","doi":"10.1126/sciadv.adv1971","DOIUrl":"10.1126/sciadv.adv1971","url":null,"abstract":"<div >Peptides are ubiquitous and important biomolecules that self-assemble into diverse structures. Although extensive research has explored the effects of chemical composition and exterior conditions on self-assembly, a systematic study consolidating these data to uncover global rules is lacking. In this work, we curate a peptide assembly database through a combination of manual processing by human experts and large language model–assisted literature mining. As a result, we collect over 1000 experimental data entries with information about peptide sequence, experimental conditions, and corresponding self-assembly phases. Using the data, machine learning models are developed, demonstrating excellent accuracy (>80%) in assembly phase classification. Moreover, we fine-tune a GPT model for peptide literature mining with the developed dataset, which markedly outperforms the pretrained model in extracting information from academic publications. This workflow can improve efficiency when exploring potential self-assembling peptide candidates, through guiding experimental work, while also deepening our understanding of the governing mechanisms.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv1971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrobiological implications of the stability and reactivity of peptide nucleic acid (PNA) in concentrated sulfuric acid

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-26 DOI: 10.1126/sciadv.adr0006

Janusz J. Petkowski, Sara Seager, Maxwell D. Seager, William Bains, Nittert Marinus, Mael Poizat, Chad Plumet, Jim van Wiltenburg, Ton Visser, Martin Poelert

{"title":"Astrobiological implications of the stability and reactivity of peptide nucleic acid (PNA) in concentrated sulfuric acid","authors":"Janusz J. Petkowski, Sara Seager, Maxwell D. Seager, William Bains, Nittert Marinus, Mael Poizat, Chad Plumet, Jim van Wiltenburg, Ton Visser, Martin Poelert","doi":"10.1126/sciadv.adr0006","DOIUrl":"10.1126/sciadv.adr0006","url":null,"abstract":"<div >Recent renewed interest regarding the possibility of life in the Venusian clouds has led to new studies on organic chemistry in concentrated sulfuric acid. However, life requires complex genetic polymers for biological function. Therefore, finding suitable candidates for genetic polymers stable in concentrated sulfuric acid is a necessary first step to establish that biologically functional macromolecules can exist in this environment. We explore peptide nucleic acid (PNA) as a candidate for a genetic-like polymer in a hypothetical sulfuric acid biochemistry. PNA hexamers undergo between 0.4 and 28.6% degradation in 98% (w/w) sulfuric acid at ~25°C, over the span of 14 days, depending on the sequence, but undergo complete solvolysis above 80°C. Our work is the first key step toward the identification of a genetic-like polymer that is stable in this unique solvent and further establishes that concentrated sulfuric acid can sustain a diverse range of organic chemistry that might be the basis of a form of life different from Earth’s.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0