Science Advances最新文献

{"title":"Enterococcus faecalis biofilm rewires neutrophil metabolism to suppress antimicrobial activity","authors":"Haris Antypas,&nbsp;Ronni Anderson Gonçalves da Silva,&nbsp;Geneve Kang Xin Wong,&nbsp;Cui Liang,&nbsp;Logeshwari Muthualagu Natarajan,&nbsp;Rachel Jing Wen Tan,&nbsp;Cheryl Jia Yi Neo,&nbsp;Siu Ling Wong,&nbsp;Kimberly A. Kline","doi":"10.1126/sciadv.aej4153","DOIUrl":"10.1126/sciadv.aej4153","url":null,"abstract":"<div ><i>Enterococcus faecalis</i> is an opportunistic pathogen that persists in biofilm-associated infections despite robust neutrophil recruitment. How <i>E. faecalis</i> evades neutrophils remains poorly understood. Here, we investigated how <i>E. faecalis</i> biofilms alter effector functions in human neutrophils and a murine wound infection model. We found that <i>E. faecalis</i> biofilm suppresses neutrophil extracellular trap (NET) formation, bacterial engulfment, and neutrophil-mediated control of biofilm growth. This suppression is partly driven by production of lactic acid through the lactate dehydrogenases (LDHs) of <i>E. faecalis</i>, which acidifies the extracellular environment, lowers neutrophil intracellular pH, and disrupts glycolysis, the tricarboxylic acid cycle, and the oxidative pentose phosphate pathway. In a murine wound infection model, loss of LDH increased neutrophil recruitment and NETosis<i>.</i> We also found that high bacterial density, a defining feature of biofilms, suppresses NETosis through a lactic acid–independent mechanism. Collectively, these findings identify biofilm immune evasion strategies mediated by bacterial metabolism and the high-density structural organization of biofilm-associated bacteria.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aej4153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CREBBP loss drives immune evasion by epigenetically silencing STING and MHC-I in small cell lung cancer","authors":"Qing Gao,&nbsp;Kehong Wei,&nbsp;Deshen Pan,&nbsp;Chaoliang Xu,&nbsp;Yufei Xi,&nbsp;Yan Zhang,&nbsp;Arnaud Augert,&nbsp;David MacPherson,&nbsp;Deshui Jia","doi":"10.1126/sciadv.aef1693","DOIUrl":"10.1126/sciadv.aef1693","url":null,"abstract":"<div >Most small cell lung cancers (SCLCs) exhibit low immunogenicity and intrinsic resistance to immunotherapy, yet the underlying mechanisms remain poorly understood. Here, we identify <i>CREBBP</i> loss, a frequent genetic alteration in SCLC, as a key suppressor of tumor cell-intrinsic immune responses that drives an immune-cold tumor microenvironment in <i>Rb1/Trp53</i>-driven autochthonous mouse models. Consistently, <i>Crebbp</i> deletion promotes immune escape in syngeneic SCLC models. Mechanistically, <i>Crebbp</i> loss suppresses <i>Sting</i> and major histocompatibility complex class-I expression by reducing histone H3 acetylation. Notably, HDAC inhibition restores histone acetylation, reactivates these silenced genes, and induces tumor cell-intrinsic immune responses. Moreover, pharmacological HDAC inhibition synergizes with immune checkpoint blockade to suppress tumor growth in both <i>Crebbp</i>-mutant and <i>Crebbp</i>-wild-type SCLCs, with a more prominent effect in <i>Crebbp</i>-mutant tumors. Collectively, these findings establish <i>CREBBP</i> loss as a key mechanism of immune evasion and immunotherapy resistance in SCLC, highlighting HDAC inhibition as a promising strategy to enhance immunotherapy efficacy.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aef1693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vortex-mediated spin current injection into two-dimensional superconductor NbSe2","authors":"Meng Yang,&nbsp;Xiaolong Yin,&nbsp;Jingjing Liu,&nbsp;Yifeng Chen,&nbsp;Qinwu Gao,&nbsp;Hongxing Zhu,&nbsp;Danni Huang,&nbsp;Lang Chen,&nbsp;Shuo-Ying Yang,&nbsp;Junxue Li","doi":"10.1126/sciadv.aeh1582","DOIUrl":"10.1126/sciadv.aeh1582","url":null,"abstract":"<div >Injection of pure spin current into superconductors remains a major challenge in superconducting spintronics. Previous studies have primarily focused on spin-polarized quasiparticles and spin-triplet supercurrents, while vortices—ubiquitous topological defects in type-II superconductors—have been theoretically proposed as alternative carriers of spin angular momentum, yet direct experimental evidence is still lacking. Here, we report the vortex-mediated spin current injection in NbSe₂/LiAl₂Fe₃O₈(LAFO) bilayer, an Ising superconductor/ferrimagnetic insulator heterostructure. Under an out-of-plane temperature gradient and an in-plane magnetic field, the NbSe₂/LAFO bilayer shows a pronounced thermoelectric peak near the upper critical magnetic field, which has the opposite sign to the conventional vortex Nernst signal observed in a single-layer NbSe₂. The sign reversal suggests that the vortex flow induced by spin current injection is opposite to the flow driven by the temperature gradient, which is consistent with theoretical mechanisms including spin-vorticity transmutation and the inverse vortex spin Hall effect. By mapping the field–temperature phase diagram, we reveal that the spin current injection occurs exclusively in the vortex liquid phase of NbSe₂. Absence of the thermoelectric signal above the superconducting transition temperature further rules out the quasiparticle contribution. Our results establish vortices as efficient carriers of spin information in superconductors, opening a new route towards vortex-mediated superconducting spintronic devices.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aeh1582","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemically encoded pH-tunable covalent adhesion by a bacterial thioester domain","authors":"Yuki Tokunaga,&nbsp;Ryo Matsunaga,&nbsp;Hiroko Kozuka-Hata,&nbsp;Masaaki Oyama,&nbsp;Kouhei Tsumoto","doi":"10.1126/sciadv.aeg7646","DOIUrl":"10.1126/sciadv.aeg7646","url":null,"abstract":"<div >Thioester domains (TEDs) represent a family of bacterial adhesin domains that mediate covalent anchoring to target ligands via an intramolecular thioester bond. Although the broad distribution of TEDs among Gram-positive bacteria suggests a critical functional role, the biological significance of this covalent mechanism remains unclear. In this study, we demonstrated that TED-mediated covalent anchoring is reversible and that its equilibrium is regulated by pH. Specifically, SfbI-TED from group A <i>Streptococcus</i> binds tightly to fibrinogen at physiological pH, whereas mild acidification to pH 6.0 induces rapid dissociation of the complex. Thermodynamic analyses indicated that this pH responsiveness is largely dictated by the intrinsic pH sensitivity of the thioester-mediated acyl transfer reaction conserved within TEDs, rather than by surface residues specific to individual TEDs. Similar pH-dependent behavior was observed in phylogenetically distinct TEDs, suggesting that pH-responsive adhesion is likely to be a broadly shared feature of TED-containing adhesins across Gram-positive bacteria.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aeg7646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A phosphorylation-gated GAPDH-MAPK6-LBD1 module controls drought-responsive transcription","authors":"Zihang He,&nbsp;Zhibo Wang,&nbsp;Caiqiu Gao,&nbsp;Xiaoyu Ji,&nbsp;Yucheng Wang","doi":"10.1126/sciadv.aek0125","DOIUrl":"10.1126/sciadv.aek0125","url":null,"abstract":"<div >Drought adaptation requires rapid spatial reorganization of signaling proteins to reprogram stress-responsive transcription, yet how phosphorylation coordinates this process remains unclear. Here we aimed to define how phosphorylation-gated protein relocalization regulates a BpLBD1-centered drought pathway in <i>Betula platyphylla</i> (birch). Drought activated two kinase branches: BpAGC phosphorylated BpMAPK6 at Ser318 within a cryptic nuclear localization signal, promoting importin α recognition, whereas BpCKII phosphorylated BpGAPDH at Thr109, Thr270, Ser279 and Thr298, promoting importin β recognition. Dual phosphorylation enabled coordinated nuclear accumulation of BpMAPK6 and BpGAPDH. In the nucleus, phosphorylated BpGAPDH acted as a scaffold-like adaptor coupling BpMAPK6 to BpLBD1, enabling BpMAPK6-mediated phosphorylation of BpLBD1 at Ser29. This weakened BpLBD1 binding to the <i>BpMYB123</i> promoter, reduced expression of the drought-sensitivity regulator <i>BpMYB123</i>, and de-repressed drought-responsive genes such as <i>BpRD29B</i>. Disrupting <i>BpGAPDH</i> or BpLBD1 Ser29 phosphorylation compromised drought tolerance. Thus, a phospho-spatial GAPDH-MAPK6-LBD1 switch couples nuclear protein assembly to drought-responsive transcription.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aek0125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological dynamics related to perception, action, and language in schizophrenia","authors":"Hsi T. Wei,&nbsp;Dominic Boutet,&nbsp;Rukun Dou,&nbsp;Jessica Ahrens,&nbsp;Nadia Zeramdini,&nbsp;Alban Voppel,&nbsp;Fernando Gonzales-Aste,&nbsp;Fatme Abboud,&nbsp;Sylvain Baillet,&nbsp;Lena Palaniyappan","doi":"10.1126/sciadv.aeh5819","DOIUrl":"10.1126/sciadv.aeh5819","url":null,"abstract":"<div >Schizophrenia disrupts both how people perceive the world and how they express and act on their thoughts, yet these symptoms are usually studied separately. Using magnetoencephalography during multisensory and motor tasks, we tested whether reduced event-related beta-band (15 to 30 hertz) modulation, a signal implicated in predictive control, provides a candidate neural marker across these domains. Compared to healthy individuals, patients showed diminished beta changes during sensory processing and movement completion, suggesting reduced flexibility in updating internal models. This neural pattern covaried with audiovisual simultaneity-judgment behavior, disorganized natural speech, and greater clinical severity. These findings suggest that distributed beta modulation may serve as a candidate cross-domain marker associated with perceptual, motor, and language disturbances in schizophrenia, motivating future studies that directly test predictive updating mechanisms.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aeh5819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple allosteric sites allow for synergistic enhancement of GPCR signaling","authors":"Kai Wang,&nbsp;Snezana T. Dimova,&nbsp;John N. Hanson,&nbsp;Abhishek Thakur,&nbsp;Youwei Xu,&nbsp;Yini Liu,&nbsp;Amy E. Moritz,&nbsp;Alexander Goldberg,&nbsp;Bing Xie,&nbsp;Jayachandra Rayadurgam,&nbsp;Feijun Wang,&nbsp;Ashley N. Nilson,&nbsp;Kathryn D. Luderman,&nbsp;R. Benjamin Free,&nbsp;Wen Hu,&nbsp;Jian Zhang,&nbsp;H. Eric Xu,&nbsp;Kevin J. Frankowski,&nbsp;Yue Wang,&nbsp;Lei Shi,&nbsp;David R. Sibley,&nbsp;Youwen Zhuang","doi":"10.1126/sciadv.aeh3401","DOIUrl":"10.1126/sciadv.aeh3401","url":null,"abstract":"<div >Allosteric modulation of G protein–coupled receptors (GPCRs) offers promising therapeutic opportunities. Although multiple allosteric binding sites have been identified in GPCRs, whether and how these spatially distinct sites cooperate to regulate receptor activation remain poorly understood. Here, we elucidate the molecular mechanism of cooperative multisite allostery in the dopamine D1 receptor (D1R). We developed two novel D1R positive allosteric modulators (PAMs), UNC9815 and UNC10062, and used cryo–electron microscopy to structurally identify two previously uncharacterized D1R allosteric sites occupied by UNC9815/UNC10062 and another D1R PAM, BMS-A1. Both sites localize to the transmembrane helix (TM) 1 to 7 interface as vertically adjacent allosteric pockets organized in a spatially complementary manner. Our structures demonstrate the simultaneous binding of the chemically distinct PAMs (LY3154207, BMS-A1, and UNC9815/UNC10062) in three nonoverlapping pockets. Concurrent engagement of all three allosteric sites produces pronounced functional cooperativity, increasing dopamine potency by &gt;1000-fold, thereby demonstrating that coordinated multisite modulation can achieve substantial pharmacological amplification beyond the limits imposed by single PAM administration. Molecular dynamics (MD) simulations revealed that multisite PAM engagement restricts intracellular loop 3 dynamics and stabilizes the TM7-NPxxY activation motif, effects not achieved by binding of LY3154207 alone, thereby biasing the receptor toward a more stabilized active conformation, and may also improve agonist potency by stabilizing extracellular loop 2. Together, these findings establish the structural framework for cooperative multisite allostery in a GPCR, revealing how distributed allosteric sites act in concert to amplify receptor activation and providing a conceptual foundation for developing innovative GPCR allosteric therapeutics.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aeh3401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High ambipolar mobility fluorinated MXene for ultrasensitive biosensing transistors","authors":"Yang Yue,&nbsp;Junhong Zhao,&nbsp;Xuejun Wang,&nbsp;Yanan Tang,&nbsp;Yunqi Liu,&nbsp;Dacheng Wei","doi":"10.1126/sciadv.aeg5289","DOIUrl":"10.1126/sciadv.aeg5289","url":null,"abstract":"<div >Transition metal carbides and nitrides (MXenes) are emerging as transformative materials for bioelectronics. However, the advancement of MXene-based field-effect transistor (FET) biosensors is hindered by the lack of high-quality aqueous-stable materials and the low signal transduction efficiency intrinsic to their metallic nature. To address these issues, we report an ultrasensitive biosensing platform enabled by an in-situ fluorination strategy of MXene. By substituting unstable oxygen-containing terminations with chemically stable fluorine terminations in a mild reaction, we synthesized high-quality fluorinated MXene with the record-breaking ambipolar field-effect mobility (μ_p = 10.42 cm² V⁻¹ s⁻¹, μ_n = 30.23 cm² V⁻¹ s⁻¹). The highly electronegative fluorinated interface suppresses interfacial electrical double-layer capacitance, boosting signal transduction efficiency. Consequently, the platform achieves the lowest limit of detection (LOD) of 0.26 fg ml⁻¹ for <i>Mycobacterium tuberculosis</i> antigen MPT64 among MXene FETs up to date, accompanied by a high current response of 35.02% at LOD. Clinical validation across 126 serum samples demonstrated a diagnostic accuracy of 97.6% with a detection time of 38 s, exhibiting the high-performance and reliable biosensing in complex physiological environments.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aeg5289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Furan fatty acids reprogram hepatic lipid metabolism via acyl-CoA conjugates in obesity","authors":"Matias M. Vazquez,&nbsp;Sonia R. Salvatore,&nbsp;Pascal Rowart,&nbsp;Sumit Kumar Anand,&nbsp;Nicole Colussi,&nbsp;Marco Fazzari,&nbsp;Aidan R. Cole,&nbsp;Cristina Espinosa-Diez,&nbsp;Soma Jobbagy,&nbsp;Jia-Jun Liu,&nbsp;Jianhua Luo,&nbsp;Delphine Gomez,&nbsp;Silvia Liu,&nbsp;Carsten Skarke,&nbsp;Fiona M. Bello,&nbsp;Michael J. Jurczak,&nbsp;Kacey J. Prentice,&nbsp;Michael B. Wheeler,&nbsp;Mohamed Trebak,&nbsp;Nicholas K.H. Khoo,&nbsp;Oren Rom,&nbsp;Fei Chang,&nbsp;Francisco J. Schopfer","doi":"10.1126/sciadv.aeg5357","DOIUrl":"10.1126/sciadv.aeg5357","url":null,"abstract":"<div >Dietary fish oil (FO) and omega-3 fatty acids are associated with cardiometabolic benefits, yet their molecular mediators remain incompletely defined. Furan fatty acids (FuFAs), a distinct lipid class enriched in FO, have emerged as potential regulators of metabolic health. Here, we identify and quantify FuFA species in prescription omega-3 formulations and natural fish oils, and synthesize structurally engineered analogs designed to isolate antioxidant activity and β-oxidation susceptibility from FuFA bioactivity. In a diet-induced obesity mouse model, both natural and synthetic FuFAs reduced fat accumulation and inflammatory markers, while 11U3-2M additionally produced significant improvement in glucose tolerance, dyslipidemia, and hepatic steatosis. The superior activity of 11U3-2M reflects the stable accumulation of its acyl-CoA conjugate that activates peroxisome proliferator-activated receptor alpha (PPARα) signaling and allosterically inhibits acetyl-CoA carboxylases (ACCs) to reprogram hepatic lipid metabolism. These findings position FuFAs as functional dietary lipids contributing to fish oil’s metabolic effects and define fatty acid structural determinants that govern hepatic metabolic activity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aeg5357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-soft organic electrochemical diodes based on asymmetric active layers for signal isolation in deformable electronics","authors":"Sehyun Kim,&nbsp;Minji Kim,&nbsp;Haechan Park,&nbsp;Kihyun Sim,&nbsp;Jihyeon Jang,&nbsp;Yerin Kim,&nbsp;Jinyeong Park,&nbsp;Donghyung Shin,&nbsp;Myeonghyeon Na,&nbsp;Kyoseung Sim","doi":"10.1126/sciadv.aei3178","DOIUrl":"10.1126/sciadv.aei3178","url":null,"abstract":"<div >All-soft electronics have emerged as a promising platform for deformable and human-centric systems, yet the development of mechanically compliant diodes remains a major challenge due to limitations in material compatibility, device architecture, and stable operation under deformation. Electrochemical approaches offer a viable route to address this challenge by enabling bulk, low-voltage charge modulation in soft materials without relying on rigid junction interfaces. Here, we report, to the best of our knowledge, the first all-soft organic electrochemical diode (OECD) based on an asymmetric active-layer geometry. The device incorporates a transfer-printed ultrathin ion-gel interface that preserves conformal coverage and the active electrochemical architecture under strain. The device achieves high rectification through polarity-dependent electrochemical potential redistribution, with a rectification ratio of up to 2.23 × 10⁴ at ±1 V and stable operation under tensile strains of up to 30% and repeated mechanical deformation. This ion-gel-based architecture preserves the electrochemical asymmetry required for diode operation while maintaining structural integrity under strain. Beyond the individual device, the all-soft OECD enables deformable rectifiers and logic gates and functions as a key signal-isolation element that suppresses cross-talk in a deformable pressure-sensing array. These results establish an electrochemical diode platform that combines mechanical deformability, high rectification performance, and circuit-level compatibility, providing a pathway toward fully deformable and integrated human-centric electronic systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 43","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.aei3178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}