Science Advances最新文献_第6页

Direct approach to high-resolution, square-lattice alternating nanodot array by breaking hexagonal symmetry of block copolymer spheres 通过打破嵌段共聚物球的六边形对称性直接实现高分辨率、方晶格交替纳米点阵列

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adx1235

Seong Eun Kim, Gabriella P. Irianti, Hyunwoo Kim, Vikram Thapar, Hyeongoo Kim, Jungki Ryu, Su-Mi Hur, So Youn Kim

{"title":"Direct approach to high-resolution, square-lattice alternating nanodot array by breaking hexagonal symmetry of block copolymer spheres","authors":"Seong Eun Kim, Gabriella P. Irianti, Hyunwoo Kim, Vikram Thapar, Hyeongoo Kim, Jungki Ryu, Su-Mi Hur, So Youn Kim","doi":"10.1126/sciadv.adx1235","DOIUrl":"10.1126/sciadv.adx1235","url":null,"abstract":"<div >Expanding the morphological spectrum of block copolymer (BCP) self-assembly remains a notable challenge in BCP-based bottom-up nanofabrication. We present a simple method to fabricate unconventional yet crucial structures of sphere-forming BCPs in thin films using solvent vapor. By precisely controlling solvent uptake, we transform the final lattice structure of spheres, modifying the thermodynamically stable lattice of BCPs. Molecular dynamics simulations reveal that increased solvent uptake elongates the spheres, raising interfacial energy and causing sphere splitting. The additional layers generated from the sphere splitting present a nonconventional lattice, typically not observed in thin films. Using these structures, we fabricate bimetallic nanodot arrays, where two different metal components are positioned alternatingly. This array exhibits higher catalytic activities compared to the homometallic nanopatterns, with the ultralow mass of noble metals below 300 nanograms per square centimeter, highlighting their potential as electrochemical catalyst platforms.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx1235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance reversible adhesive from PET waste for underwater, structural, and pressure-sensitive applications 从PET废料中提取的高性能可逆粘合剂，适用于水下、结构和压敏应用

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adw1288

Mary K. Danielson, Bobby G. Sumpter, Zoriana Demchuk, Catalin Gainaru, Chuyi Pan, Tomonori Saito, Md Anisur Rahman

{"title":"High-performance reversible adhesive from PET waste for underwater, structural, and pressure-sensitive applications","authors":"Mary K. Danielson, Bobby G. Sumpter, Zoriana Demchuk, Catalin Gainaru, Chuyi Pan, Tomonori Saito, Md Anisur Rahman","doi":"10.1126/sciadv.adw1288","DOIUrl":"10.1126/sciadv.adw1288","url":null,"abstract":"<div >Developing versatile, tough, and sustainable adhesives that function effectively in both wet and dry environments is a major challenge. Here, we report a bioinspired design for versatile, tough, and reversible adhesives upcycled from consumer poly(ethylene terephthalate) (PET) waste. Our approach uses solvent-free, room-temperature dynamic cross-linking of deconstructed PET macromonomers with a diacetoacetate cross-linker, generating a dynamic, vinylogous urethane–bonded, amphiphilic adhesive. Tunable cross-linker concentration and amphiphilicity yield versatile adhesives suitable for underwater, structural, and pressure-sensitive applications on diverse substrates. Our adhesive exhibits high lap-shear strength and work of debonding under both wet and dry conditions, outperforming common commercial adhesives. The dynamic bonds enable thermal repair, on-demand multicycle debonding/rebonding, facile removal, and chemical recycling. Our strategy of transforming plastic waste into versatile, tough, and reversible adhesives offers a sustainable solution for both plastic waste management and next-generation adhesive design while also providing a commercially viable pathway for valorizing plastic waste.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw1288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption 胶质瘤血管系统全脑全景图的构建揭示了肿瘤的异质性和血脑屏障的破坏

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adw8330

Chenxi Huang, Xiaohong Xin, Xiaoxu Hao, Shilin Zhou, Zongneng Xie, Lijuan He, Xiaoliang Li, Yu Zhang, Hongyu Sun, Jiwen Zhang, Xiaochuan Zhang, Xianzhen Yin

{"title":"Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption","authors":"Chenxi Huang, Xiaohong Xin, Xiaoxu Hao, Shilin Zhou, Zongneng Xie, Lijuan He, Xiaoliang Li, Yu Zhang, Hongyu Sun, Jiwen Zhang, Xiaochuan Zhang, Xianzhen Yin","doi":"10.1126/sciadv.adw8330","DOIUrl":"10.1126/sciadv.adw8330","url":null,"abstract":"<div >Vasculature-induced tumor tissue heterogeneity impedes predicable drug distribution and presents notable challenges for optimizing nanoparticle (NP)–based drug delivery. However, mesoscopic-scale tumor heterogeneity across entire brain remains poorly characterized. To address this, we integrated micro-optical sectioning tomography (MOST) with high-precision three-dimensional (3D) reconstruction analysis to map pathological features of orthotopic glioma at submicron resolution across whole mice brain. Our findings uncovered significant heterogeneity in glioma invasiveness, vasculature, and compensatory angiogenesis while precisely delineating NP distribution throughout the tumor. Notably, early-stage glioma co-opted and migrated 680-micrometer upstream along the main cerebral artery within 4 days after glioma implantation. Blood-brain barrier permeability gradually increased during glioma progression, enabling NP penetrated via large-diameter vessels instead being restricted to capillaries. This work establishes a multiscale, high-resolution, 3D atlas of glioma heterogeneity and NP distribution, and bridges mesoscopic structural complexity to functional drug delivery barriers, advancing strategies to enhance oncotherapy precision in heterogeneous brain tumors.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw8330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tandem reaction-adsorption separation of perfluorinated cyclopropane/propane mixtures 串联反应-吸附分离全氟环丙烷/丙烷混合物

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adt9498

Xinxin Li, Weiwei Zhang, Guang Miao, Zhikang Wu, Xingjie Wang, Xuan Wei, Zewei Liu, Hao Tang, Cuiting Yang, Jing Xiao

引用次数: 0

Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways 代谢组织源性柠檬酸生物材料通过柠檬酸介导的信号通路协调骨再生

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.ady2862

Hui Xu, Xinyu Tan, Ethan Gerhard, Hao Zhang, Rohitraj Ray, Yuqi Wang, Sri-Rajasekhar Kothapalli, Elias B. Rizk, April D. Armstrong, Su Yan, Jian Yang

{"title":"Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways","authors":"Hui Xu, Xinyu Tan, Ethan Gerhard, Hao Zhang, Rohitraj Ray, Yuqi Wang, Sri-Rajasekhar Kothapalli, Elias B. Rizk, April D. Armstrong, Su Yan, Jian Yang","doi":"10.1126/sciadv.ady2862","DOIUrl":"10.1126/sciadv.ady2862","url":null,"abstract":"<div >Bone regeneration requires coordinated anabolic and catabolic signaling, yet the interplay between mammalian target of rapamycin complex 1 (mTORC1) and adenosine monophosphate–activated protein kinase (AMPK) pathways remains unclear. This study reveals that citrate, glutamine, and magnesium synergistically activate both pathways via calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2)– and protein kinase B (Akt)–dependent signaling, bypassing the traditional adenosine monophosphate (AMP)/adenosine triphosphate (ATP) sensing mechanism. This dual activation supports sustained energy metabolism during osteogenesis and challenges the canonical antagonism between mTORC1 and AMPK. We developed CitraBoneQMg, a citrate-based biomaterial incorporating these components via one-pot synthesis. CitraBoneQMg provides sustained release, photoluminescent and photoacoustic imaging capabilities, and tunable mechanical properties. In vitro, it promotes osteogenesis by enhancing alkaline phosphatase (ALP) activity, osteogenic gene expression, and calcium deposition. In vivo, it accelerates bone regeneration in a rat calvarial defect model while promoting anti-inflammatory and neuroregenerative responses. We define this integrated effect as “metabotissugenesis,” offering a metabolically optimized approach to orthopedic biomaterial design.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady2862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the success and failure of online political debate: Experimental evidence using large language models 理解在线政治辩论的成败：使用大型语言模型的实验证据

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adv7864

Tobias Heide-Jørgensen, Gregory Eady, Anne Rasmussen

{"title":"Understanding the success and failure of online political debate: Experimental evidence using large language models","authors":"Tobias Heide-Jørgensen, Gregory Eady, Anne Rasmussen","doi":"10.1126/sciadv.adv7864","DOIUrl":"10.1126/sciadv.adv7864","url":null,"abstract":"<div >Online political debate is frequently lamented for being toxic, partisan, and counterproductive. However, we know little about how core elements of political debate (justification, tone, willingness to compromise, and partisanship) affect its quality. Using text-based treatments experimentally manipulated with a large language model, we test how these elements causally affect the quality of open-text responses about issues important to the US and UK public. We find substantial evidence that differences in justification, tone, and willingness to compromise, but not partisanship, affect the quality of subsequent discourse. Combined, these elements increase the probability of high-quality responses by roughly 1.6 to 2 times and substantially increase openness to alternative viewpoints. Despite the ability to bring about substantial changes in discourse quality, we find no evidence of changes in political attitudes themselves. Our findings demonstrate how adapting approaches to online debate can foster healthy democratic interactions but have less influence on changing minds.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv7864","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodiversity-friendly landscapes: A paradox for conservation? 生物多样性友好型景观：保护的悖论？

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adt9564

Eliane Seraina Meier, Alexander Indermaur, Eva Knop

{"title":"Biodiversity-friendly landscapes: A paradox for conservation?","authors":"Eliane Seraina Meier, Alexander Indermaur, Eva Knop","doi":"10.1126/sciadv.adt9564","DOIUrl":"10.1126/sciadv.adt9564","url":null,"abstract":"<div >Human-induced global change may cause the sixth mass extinction of species. The moderate success of patch-scale biodiversity conservation measures has led to the concept of creating biodiversity-friendly landscapes. However, these landscapes potentially present a paradox: They may increase local biodiversity and thereby strengthen biotic resistance of native communities to global change winners, i.e., species that thrive under global change, such as invasive alien species or temperature- or nutrient-tolerant species. However, they may also improve landscape-scale habitat conditions, such as habitat connectivity, which facilitates the dispersal of global change winners, thereby accelerating biodiversity loss. Despite increasing investment in biodiversity-friendly landscapes, this paradox and underlying processes remain largely unquantified. We analyzed 2050 repeated, systematic vegetation surveys across the Swiss farmland and found the hypothesized facilitating and inhibitory effects on global change winners, but, overall, the inhibitory effects were stronger. This supports the call for a shift from patch-scale conservation to landscape-wide strategies to stop the ongoing decline of farmland biodiversity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt9564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidden white and black feather layers enhance plumage coloration in tanagers and other songbirds 隐藏的白色和黑色羽毛层增强了manager和其他鸣禽的羽毛颜色

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adw5857

Rosalyn M. Price-Waldman, Jarome R. Ali, Allison J. Shultz, Benedict G. Hogan, Mary Caswell Stoddard

{"title":"Hidden white and black feather layers enhance plumage coloration in tanagers and other songbirds","authors":"Rosalyn M. Price-Waldman, Jarome R. Ali, Allison J. Shultz, Benedict G. Hogan, Mary Caswell Stoddard","doi":"10.1126/sciadv.adw5857","DOIUrl":"10.1126/sciadv.adw5857","url":null,"abstract":"<div >Birds are renowned for their diverse and colorful plumage. Here, we demonstrate that vibrant plumage in the tanager genus <i>Tangara</i> is substantially intensified by a “hidden” layer of achromatic (white or black) plumage concealed beneath the outermost colorful layer. Using hyperspectral imaging, multispectral photography, microspectrophotometry, reflectance spectrophotometry, and optical modeling, we show that hidden white and black feather layers are systematically distributed on the body to enhance the brightness and saturation of carotenoid-pigmented and structurally colored plumage, respectively, by increasing or decreasing the amount of backscattered light that interacts with pigments or nanostructures. We compare male and female coloration and show that sexual dichromatism in some <i>Tangara</i> carotenoid plumage stems primarily from white layers in males and black layers in females rather than from differences in carotenoid pigmentation. Last, we find that white and black hidden feather layers are widespread in colorful passerines. Hidden feather layers likely play a previously overlooked but critical role in colorful plumage evolution in birds.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw5857","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary escalation in an exceptionally preserved Cambrian biota from the Grand Canyon (Arizona, USA) 大峡谷（美国亚利桑那州）保存完好的寒武纪生物群的进化升级

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adv6383

Giovanni Mussini, James W. Hagadorn, Anne E. Miller, Karl E. Karlstrom, Rhydian Evans, Carol E. Dehler, Salvador Bastien, Nicholas J. Butterfield

{"title":"Evolutionary escalation in an exceptionally preserved Cambrian biota from the Grand Canyon (Arizona, USA)","authors":"Giovanni Mussini, James W. Hagadorn, Anne E. Miller, Karl E. Karlstrom, Rhydian Evans, Carol E. Dehler, Salvador Bastien, Nicholas J. Butterfield","doi":"10.1126/sciadv.adv6383","DOIUrl":"10.1126/sciadv.adv6383","url":null,"abstract":"<div >Exceptionally preserved fossil assemblages, or Konservat-Lagerstätten, open direct windows on non-biomineralized faunas that chronicle the Cambrian radiation of animal phyla. However, these assemblages do not typically capture the well-oxygenated, resource-rich environments sustaining most metazoan diversity in modern marine systems. We describe exceptionally preserved and articulated carbonaceous mesofossils from the middle Cambrian (~507 to 502 million years) Bright Angel Formation of the Grand Canyon (Arizona, USA). This biota preserves probable algal and cyanobacterial photosynthesizers together with a range of functionally sophisticated metazoan consumers: suspension-feeding crustaceans, substrate-scraping molluscs, and morphologically exotic priapulids with complex filament-bearing teeth, convergent on modern microphagous forms. The Grand Canyon’s extensive ichnofossil and sedimentological records show that these phylogenetically and functionally derived taxa occupied highly habitable shallow-marine environments, sustaining higher levels of benthic activity than broadly coeval macrofossil Konservat-Lagerstätten. These data suggest that evolutionary escalation in resource-rich Cambrian shelf settings was an important driver of the assembly of later Phanerozoic ecologies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv6383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective engagement of prefrontal VIP neurons in reversal learning 前额叶VIP神经元在逆向学习中的选择性参与

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adt4945

Jee Hyun Yi, Young Ju Yoon, Huijeong Jeong, Seo Yeon Choe, Min Whan Jung

{"title":"Selective engagement of prefrontal VIP neurons in reversal learning","authors":"Jee Hyun Yi, Young Ju Yoon, Huijeong Jeong, Seo Yeon Choe, Min Whan Jung","doi":"10.1126/sciadv.adt4945","DOIUrl":"10.1126/sciadv.adt4945","url":null,"abstract":"<div >To gain insights into neural mechanisms enabling behavioral adaptations to complex and multidimensional environmental dynamics, we examined roles of vasoactive intestinal polypeptide (VIP)–expressing neurons in mouse medial prefrontal cortex (mPFC) in probabilistic reversal learning. Behaviorally, manipulating VIP neuronal activity left probabilistic classical conditioning unaffected but severely impaired reversal learning. Physiologically, conditioned cue-associated VIP neuronal responses changed abruptly after encountering an unexpected reward. They also conveyed strong reward prediction error signals during behavioral reversal, but not before or after, unlike pyramidal neurons that consistently conveyed error signals throughout all phases. Furthermore, the signal’s persistence across trials correlated with reversal learning duration. These results suggest that mPFC VIP neurons play crucial roles in rapid reversal learning, but not in gradual value updating under stable probabilistic contingencies, by monitoring salient deviations from ongoing environmental contingencies and imposing error-correction signals during behavioral adjustments. These findings shed light on the intricate cortical circuit dynamics underpinning behavioral flexibility in complex, multifaceted environments.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt4945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0