Science Advances最新文献

{"title":"Supramolecular hydrogel actuators with reprogrammable magnetic orientation by locally mediated viscoelasticity and pinning force","authors":"Chuan Wei Zhang,&nbsp;Xing Peng Hao,&nbsp;Weifeng Zou,&nbsp;Zhixin Zhu,&nbsp;Jia Yu Hu,&nbsp;Li Xin Hou,&nbsp;Si Rui Xu,&nbsp;Zhen Luo,&nbsp;Yichen Yan,&nbsp;Andrea Sarabia,&nbsp;Andrea Litwak,&nbsp;Shili Xu,&nbsp;Zhi Jian Wang,&nbsp;Ximin He,&nbsp;Qiang Zheng,&nbsp;Zi Liang Wu","doi":"","DOIUrl":"","url":null,"abstract":"<div >Magnetic soft actuators with reprogrammable deformations have gained substantial attention due to their adaptability for various applications. However, achieving precise and local reorientation of magnetic particles remains challenging. Here, we present a strategy to locally tailor the viscoelasticity of magnetic supramolecular hydrogels, facilitate reorientation of the embedded magnetic particles, and enable reprogrammable magnetoactuated deformation and locomotion of the composite gels. The magnetic hydrogels are facilely prepared by mixing neodymium-iron-boron particles with an aqueous poly(acrylic acid–<i>co</i>–acrylamide) solution, which spontaneously forms supramolecular network with carboxylic–ferric ion coordinates as physical cross-links. This network enables dynamic control of viscoelasticity by localized laser heating, which reduces the pinning force of gel matrix and allows for reorientation of magnetic particles under a modest magnetic field. We demonstrate that the same hydrogel sheet can be reprogrammed to exhibit various complex deformations and locomotion. This versatile approach to developing magnetic hydrogels with adaptive responses offers exciting potential for soft robotics and biomedical devices.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw0500","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Past intrusion of Circumpolar Deep Water in the Ross Sea: Impacts on the ancient Ross Ice Shelf","authors":"Chiara Pambianco,&nbsp;Alessio Nogarotto,&nbsp;Mathia Sabino,&nbsp;Lucilla Capotondi,&nbsp;Francesca Battaglia,&nbsp;Federico Giglio,&nbsp;Gesine Mollenhauer,&nbsp;Jens Hefter,&nbsp;Alessio Di Roberto,&nbsp;Simon T. Belt,&nbsp;Enrico Pochini,&nbsp;Francesco Muschitiello,&nbsp;Andrea Geniram,&nbsp;Ester Colizza,&nbsp;Giulia Giorgetti,&nbsp;Fiorenza Torricella,&nbsp;Tommaso Tesi","doi":"","DOIUrl":"","url":null,"abstract":"<div >The Ross Ice Shelf, Antarctica’s largest by area, may face increased instability under future warming, threatening the Antarctic Ice Sheet. Understanding its past response to climate change is critical for anticipating future sea-level rise. We present a multi-proxy reconstruction of ocean and cryosphere conditions in the Ross Sea over the past 40,000 years. Our data show that warm Circumpolar Deep Water reached the JOIDES Trough in the western Ross Sea shortly after the Last Glacial Maximum, coinciding with the retreat of an ancestral ice shelf. This oceanic warming aligns with a southward shift of both the westerly and easterly wind belts, indicating a large-scale atmospheric mechanism driving regional ocean changes. The timing and nature of these processes reveal the tight coupling between atmospheric circulation, ocean heat transport, and ice shelf dynamics. These interactions led to reduced ice shelf extent, highlighting the role of ocean-atmosphere coupling in the Pacific sector of the Southern Ocean during deglaciation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt7075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing neurovascular coupling at a high spatial and temporal resolution in the living human retina","authors":"Pierre Senée,&nbsp;Léa Krafft,&nbsp;Inès Loukili,&nbsp;Daniela Castro Farias,&nbsp;Olivier Thouvenin,&nbsp;Michael Atlan,&nbsp;Michel Paques,&nbsp;Serge Meimon,&nbsp;Pedro Mecê","doi":"","DOIUrl":"","url":null,"abstract":"<div >Neurovascular coupling (NVC) regulates local blood flow in response to neuronal activity, yet its precise characterization at the capillary level has been hindered by the lack of a noninvasive, high-resolution imaging method. Here, we introduce the adaptive optics rolling slit ophthalmoscope, a unique noninvasive, label-free, high-speed, cellular-resolution clinical imaging system for assessing retinal NVC in the living human eye. Using an off-axis phase contrast approach combined with camera-based confocal slit gating, our method provides large field-of-view imaging of arterial and venular walls, enabling the study of vascular dynamics with unprecedented spatiotemporal precision. Our findings highlight that this level of precision is essential for accurately distinguishing NVC-driven vasodilation from spontaneous fluctuations, such as vasomotion and the cardiac cycle. By bridging the gap between fundamental neurovascular research and clinical applications, this approach offers a powerful tool for neuroscience research and early disease detection and monitoring of neurodegenerative and vascular disorders.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx2941","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VIRMA-mediated m6A modification regulates forebrain formation through modulating ribosome biogenesis","authors":"Min Wu,&nbsp;Xiaoli Wu,&nbsp;Haifeng Sun,&nbsp;Wen Wang,&nbsp;Leyi Zhang,&nbsp;Xia Liu,&nbsp;Yifan Zhang,&nbsp;Xinning Zhang,&nbsp;Jun Liu,&nbsp;Bin Shen,&nbsp;Tao Zhou","doi":"","DOIUrl":"","url":null,"abstract":"<div ><i>N</i>⁶-Methyladenosine (m⁶A) modification plays crucial roles in tissue development and homeostasis. However, the mechanisms underlying cellular adaptation of m⁶A modification and their impact on protein synthesis machinery remain unclear. VIRMA, the largest and evolutionarily conserved core of the m⁶A methyltransferase complex, is highly expressed in the embryonic brain and various cancers. Here, we demonstrate that VIRMA-mediated m⁶A modification is essential for active ribosome biogenesis. VIRMA depletion destabilizes the entire writer complex and reduces m⁶A levels, leading to decreased proliferation and increased apoptosis of neural progenitor/stem cells, ultimately causing severe forebrain developmental defects. Mechanistically, VIRMA depletion impairs ribosome biogenesis by inhibiting mRNA decay, triggering a p53-dependent stress response and compromising global protein synthesis. These findings extend to some cancer cells, suggesting a potential conservation of this mechanism. Overall, our study reveals the critical role of m⁶A in adapting protein synthesis machinery during brain development.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq9643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upgrading biocrude oil into sustainable aviation fuel using zeolite-supported iron-molybdenum carbide nanocatalysts","authors":"Siying Yu,&nbsp;Haozhen He,&nbsp;Sabrina Summers,&nbsp;Zhibin Yang,&nbsp;Buchun Si,&nbsp;Runnan Gao,&nbsp;Anran Song,&nbsp;Joshua Heyne,&nbsp;Yuanhui Zhang,&nbsp;Hong Yang","doi":"","DOIUrl":"","url":null,"abstract":"<div >Food waste is an underdeveloped source for production of sustainable aviation fuel (SAF). Now, there is no certified conversion process of food waste for SAF by American Society for Testing and Materials (ASTM). We report the use of zeolite-supported molybdenum carbide nanocatalysts in upgrading biocrudes, produced from food wastes through HTL, into SAF precursors. Our data show a complete removal of oxygen from the biocrude through hydrodeoxygenation and a higher heating value of 46.5 MJ/kg, which is comparable to that of Jet A (46.1 MJ/kg). The prescreening tests (tier alpha and beta) show the average carbon number of the distillation cut (150° to 230°C) of upgraded fuel is 10.6, close to the value of 11.4 for average conventional jet fuel, and the specifications of properties including surface tension, viscosity, heating value, flash point, and freezing point were found to meet the standards of SAF. The metal carbide nanocatalysts were reusable in upgrading tests, and the activity of deoxygenation was retained.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu5777","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for the Research Article \"ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication\" by D. Wang <i>et al</i>.","authors":"","doi":"10.1126/sciadv.adz5386","DOIUrl":"10.1126/sciadv.adz5386","url":null,"abstract":"","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":"eadz5386"},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5.","authors":"Wen-An Wang, Evandro Ferrada, Christoph Klimek, Tanja Osthushenrich, Aidan MacNamara, Tabea Wiedmer, Giulio Superti-Furga","doi":"10.1126/sciadv.adx3011","DOIUrl":"10.1126/sciadv.adx3011","url":null,"abstract":"<p><p>Citrate is an essential metabolite playing critical roles in metabolism and as a neuromodulator during cellular differentiation and development. Mutations in the human citrate transporter SLC13A5, highly expressed in neurons, have been associated with a debilitating form of epileptic encephalopathy. In this study, we used deep mutational scanning to reveal the effect of 90% of all possible single missense variants on the structure and function of SLC13A5. Computational analyses and a detailed experimental validation of 38 variants revealed an accuracy of 86% and provided mechanistic interpretations for deleterious mutations, including the effect on protein stability, trafficking, and citrate transport. Analyses of blood citrate concentration from individuals enrolled in the UK Biobank study supported our analyses. The results illustrate an unbiased mutational landscape of the citrate transporter, illuminate mechanisms of pathogenicity, and offer a platform for the analysis of specific variants as well as opportunities for the future development of intervention strategies.</p>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":"eadx3011"},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways of blue carbon export from kelp and seagrass beds along the Atlantic coast of Nova Scotia","authors":"Kira A. Krumhansl,&nbsp;Katherine C. Lee,&nbsp;Yongxing Ma,&nbsp;Yongsheng Wu,&nbsp;Thomas H. A. Baker,&nbsp;Melisa C. Wong,&nbsp;Kumiko Azetsu-Scott,&nbsp;Wendy C. Gentleman","doi":"","DOIUrl":"","url":null,"abstract":"<div >Coastal vegetated ecosystems are recognized for their role in cycling and storing carbon in the world’s oceans (i.e., blue carbon); however, high uncertainty in carbon sequestration rates is partly due to an absence of studies estimating carbon export to the deep sea. We modeled export from nearshore kelp forests and seagrass beds, showing variability by orders of magnitude across spatial scales (3 to hundreds of kilometers), kelp and seagrass species, seasons, and carbon forms, raising caution in using generalized export rates in blue carbon accounting. Our results also show rapid (20 to 30 days) and extensive export of neutrally buoyant dissolved organic carbon particles to the shelf break (up to 44% within 90 days), contrasting sinking particulate organic carbon particles that largely remained within 100-meter water depth in the nearshore. These results improve estimates of carbon sequestration by blue carbon ecosystems and reveal contrasting patterns of export relative to other regions of the globe.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw1952","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual charge density wave introduced by the Janus structure in monolayer vanadium dichalcogenides","authors":"Ziqiang Xu,&nbsp;Yan Shao,&nbsp;Chun Huang,&nbsp;Chao Zhu,&nbsp;Genyu Hu,&nbsp;Shihao Hu,&nbsp;Zhi-Lin Li,&nbsp;Xiaoyu Hao,&nbsp;Yanhui Hou,&nbsp;Teng Zhang,&nbsp;Liwei Liu,&nbsp;Jin-An Shi,&nbsp;Chen Liu,&nbsp;Jia-Ou Wang,&nbsp;Wu Zhou,&nbsp;Jiadong Zhou,&nbsp;Wei Ji,&nbsp;Yeliang Wang,&nbsp;Chendong Zhang,&nbsp;Jingsi Qiao,&nbsp;Hong-Jun Gao,&nbsp;Xu Wu","doi":"","DOIUrl":"","url":null,"abstract":"<div >As a fundamental structural feature, the symmetry of materials determines the exotic quantum properties in transition metal dichalcogenides (TMDs) with charge density waves (CDWs). The Janus structure, an artificially constructed lattice, provides an opportunity to tune the electronic structures and their associated behavior, such as CDW states. However, limited by the difficulties in atomic-level fabrication and material stability, the experimental visualization of the CDW states in two-dimensional (2D) TMDs with Janus structure is still rare. Here, using surface selenization of VTe₂, we fabricated monolayer Janus VTeSe. With scanning tunneling microscopy, we observed and characterized an unusual <span><math><mrow><msqrt><mn>13</mn></msqrt><mo>×</mo><msqrt><mn>13</mn></msqrt></mrow></math></span> CDW state with threefold rotational symmetry breaking. Combined with theoretical calculations, we find that this CDW state can be attributed to the magnetic-involved charge modulation in the Janus VTeSe, rather than the conventional electron-phonon coupling. Our findings provide a promising platform for studying the CDW states and artificially tuning the electronic properties of the 2D TMDs toward the related fundamental and applied studies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq4406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase 2/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX/COVID-12 vaccine","authors":"Constantino López-Macías,&nbsp;Martha Torres,&nbsp;Brenda Armenta-Copca,&nbsp;Niels H. Wacher,&nbsp;Arturo Galindo-Fraga,&nbsp;Laura Castro-Castrezana,&nbsp;Andrea Alicia Colli-Domínguez,&nbsp;Edgar Cervantes-Trujano,&nbsp;Isabel Erika Rucker-Joerg,&nbsp;Fernando Lozano-Patiño,&nbsp;Juan José Rivera-Alcocer,&nbsp;Abraham Simón-Campos,&nbsp;Efrén Alberto Sánchez-Campos,&nbsp;Rafael Aguirre-Rivero,&nbsp;Alejandro José Muñiz-Carvajal,&nbsp;Luis del Carpio-Orantes,&nbsp;Francisco Márquez-Díaz,&nbsp;Tania Rivera-Hernández,&nbsp;Alejandro Torres-Flores,&nbsp;Luis Ramírez-Martínez,&nbsp;Georgina Paz-De la Rosa,&nbsp;Oscar Rojas-Martínez,&nbsp;Alejandro Suárez-Martínez,&nbsp;Gustavo Peralta-Sánchez,&nbsp;Claudia Carranza,&nbsp;Esmeralda Juárez,&nbsp;Horacio Zamudio-Meza,&nbsp;Laura E. Carreto-Binaghi,&nbsp;Mercedes Viettri,&nbsp;Damaris Romero-Rodríguez,&nbsp;Andrea Palencia,&nbsp;David Sarfati-Mizrahi,&nbsp;Weina Sun,&nbsp;Héctor Elías Chagoya-Cortés,&nbsp;Felipa Castro-Peralta,&nbsp;Peter Palese,&nbsp;Florian Krammer,&nbsp;Adolfo García-Sastre,&nbsp;Bernardo Lozano-Dubernard","doi":"","DOIUrl":"","url":null,"abstract":"<div >Low- and middle-income countries face substantial challenges in immunizing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including high costs, limited access, and insufficient local manufacturing. To address these issues, we developed and locally manufactured the AVX/COVID-12 vaccine using a cost-effective Newcastle disease virus LaSota platform to express a stabilized SARS-CoV-2 spike protein (HexaPro-S). We evaluated the AVX/COVID-12 vaccine in a phase 2/3 parallel-group, double-blind, active-controlled, noninferiority trial with 4056 volunteers, demonstrating its safety, good tolerability, and ability to induce neutralizing antibodies against ancestral SARS-CoV-2 and the Omicron BA.2 and BA.5 variants. It also stimulated interferon-γ–producing CD8⁺ T cells and met the World Health Organization’s noninferiority criteria compared to AZ/ChAdOx-1-S. No vaccinated participants experienced severe disease, hospitalization, or death. These findings support the use of AVX/COVID-12 as a booster to help achieve and maintain population immunity while addressing global inequities in vaccine distribution, and it has been approved for adult booster use in Mexico.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 26","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq2887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}