Science Advances最新文献_第6页

Interleukin-4 modulates type I interferon to augment antitumor immunity 白细胞介素-4调节I型干扰素增强抗肿瘤免疫

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adt3618

Hannah V. Newnes, Jesse D. Armitage, Anthony C. Buzzai, Emma de Jong, Katherine M. Audsley, Samantha A. Barnes, Shamini Srinivasan, Michael Serralha, Vanessa S. Fear, Belinda B. Guo, Matt E. Jones, Alistair R. R. Forrest, Bree Foley, Phil K. Darcy, Paul A. Beavis, Anthony Bosco, Jason Waithman

{"title":"Interleukin-4 modulates type I interferon to augment antitumor immunity","authors":"Hannah V. Newnes, Jesse D. Armitage, Anthony C. Buzzai, Emma de Jong, Katherine M. Audsley, Samantha A. Barnes, Shamini Srinivasan, Michael Serralha, Vanessa S. Fear, Belinda B. Guo, Matt E. Jones, Alistair R. R. Forrest, Bree Foley, Phil K. Darcy, Paul A. Beavis, Anthony Bosco, Jason Waithman","doi":"10.1126/sciadv.adt3618","DOIUrl":"10.1126/sciadv.adt3618","url":null,"abstract":"<div >Despite advances in immunotherapy, metastatic melanoma remains a considerable therapeutic challenge due to the complexity of the tumor microenvironment. Intratumoral type I interferon (IFN-I) has long been associated with improved clinical outcomes. However, several IFN-I subtypes can also paradoxically promote tumor growth in some contexts. We investigated this further by engineering murine B16 melanoma cells to overexpress various IFN-I subtypes, where a spectrum of outcomes was observed. Characterization of these tumors by RNA sequencing revealed a tumor immune phenotype, where potent IFN-I signaling concomitant with diminished type 2 inflammation failed to confer durable tumor control. T cell–mediated rejection of these tumors was restored by introducing interleukin-4 (IL-4) into the tumor microenvironment, either through ectopic expression or in a preclinical adoptive T cell therapy model. Collectively, our findings highlight the IFN-I/IL-4 axis in promoting antitumor immunity, which could be harnessed to target and stratify solid tumors that are nonresponsive to frontline therapies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt3618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerating ion transport in polycrystalline conductors: On pores and grain boundaries 多晶导体中加速离子输运：关于孔隙和晶界

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adt7795

Erica Truong, Sawankumar V. Patel, Haoyu Liu, Yudan Chen, Valentina Lacivita, Chi Zhang, Ifeoluwa P. Oyekunle, Islamiyat Ojelade, Yongkang Jin, Brendon T. Jones, Lincoln J. Miara, Vinayak P. Dravid, Hanwei Gao, Ryounghee Kim, Yan Wang, Yan-Yan Hu

{"title":"Accelerating ion transport in polycrystalline conductors: On pores and grain boundaries","authors":"Erica Truong, Sawankumar V. Patel, Haoyu Liu, Yudan Chen, Valentina Lacivita, Chi Zhang, Ifeoluwa P. Oyekunle, Islamiyat Ojelade, Yongkang Jin, Brendon T. Jones, Lincoln J. Miara, Vinayak P. Dravid, Hanwei Gao, Ryounghee Kim, Yan Wang, Yan-Yan Hu","doi":"10.1126/sciadv.adt7795","DOIUrl":"10.1126/sciadv.adt7795","url":null,"abstract":"<div >Polycrystalline ion conductors are widely used as solid electrolytes in energy storage technologies. However, they often exhibit poor ion transport across grain boundaries and pores. This work demonstrates that strategically tuning the mesoscale microstructures, including pore size, pore distribution, and chemical compositions of grain boundaries, can improve ion transport. Using LiTa<sub>2</sub>PO<sub>8</sub> as a case study, we have shown that the combination of LiF as a sintering agent with Hf<sup>4+</sup> implantation improves grain-grain contact, resulting in smaller, evenly distributed pores, reduced chemical contrast, and minimized nonconductive impurities. A suite of techniques has been used to decouple the effects of LiF and Hf<sup>4+</sup>. Specifically, LiF modifies particle shape and breaks large pores into smaller ones, while Hf<sup>4+</sup> addresses the chemical mismatches between grains and grain boundaries. Consequently, this approach achieves nearly two orders of magnitude improvement in ion conduction. Tuning mesoscale structures offers a cost-effective method for enhancing ion transport in polycrystalline systems and has notable implications for synthesizing high-performance ionic materials.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt7795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant room-temperature terahertz photothermoelectric response mediated by hot carriers at the metal-semimetal interfaces 金属-半金属界面上热载流子介导的巨大室温太赫兹光热电响应

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adv0768

Miao Cai, Jinhua Zhang, Yuanbo Chen, Liang Hong, Jingjing Fu, Xingguo Zheng, Yifan Yao, Shichen Zhang, Yinjun Liu, Boyu Dong, Shu Chen, Ping Li, Guanjun You, Junwen Zhang, Xuguang Guo, Yiming Zhu, Songlin Zhuang

{"title":"Giant room-temperature terahertz photothermoelectric response mediated by hot carriers at the metal-semimetal interfaces","authors":"Miao Cai, Jinhua Zhang, Yuanbo Chen, Liang Hong, Jingjing Fu, Xingguo Zheng, Yifan Yao, Shichen Zhang, Yinjun Liu, Boyu Dong, Shu Chen, Ping Li, Guanjun You, Junwen Zhang, Xuguang Guo, Yiming Zhu, Songlin Zhuang","doi":"10.1126/sciadv.adv0768","DOIUrl":"10.1126/sciadv.adv0768","url":null,"abstract":"<div >The hot-carrier photothermoelectric (PTE) effect in two-dimensional materials can be used to develop room-temperature, fast, and sensitive detectors for microwave, terahertz, and far-infrared radiations. Here, we present a van der Waals semimetal PtSe<sub>2</sub> terahertz detector and find a giant terahertz PTE response mediated by hot carriers at the metal-PtSe<sub>2</sub> interfaces. The detector demonstrates an excellent zero-bias responsivity of 0.62 ampere per watt (A/W), a low-noise equivalent power of 19.6 picowatt per square root of hertz (pW/Hz<sup>1/2</sup>), and a fast response time of 4.5 nanosecond (ns) at 0.1 terahertz (THz). The metal doping effect and asymmetric terahertz heating play vital roles in the hot-carrier PTE response at the metal-semimetal interfaces. Moreover, scanning photocurrent mapping shows that the short-wave zero-bias photoresponse is closely localized to the metal-semimetal interfaces, further revealing the metal doping effect. The bias-dependent photocurrent indicates that the short-wave photoresponse still originates from the PTE effect and the photovoltaic response is negligible. Our results provide important guidance for developing high performance semimetal detectors.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv0768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The big impact of small quakes on tectonic tremor synchronization 小地震对构造地震同步的大影响

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adu7173

Gaspard Farge, Emily E. Brodsky

引用次数: 0

Phalangeal cortical bone distribution reveals different dexterous and climbing behaviors in Australopithecus sediba and Homo naledi 指骨皮质骨分布揭示了南方古猿sediba和纳莱迪人不同的灵巧和攀爬行为

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adt1201

Samar M. Syeda, Christopher J. Dunmore, Matthew M. Skinner, Lee R. Berger, Steven E. Churchill, Bernhard Zipfel, Tracy L. Kivell

{"title":"Phalangeal cortical bone distribution reveals different dexterous and climbing behaviors in Australopithecus sediba and Homo naledi","authors":"Samar M. Syeda, Christopher J. Dunmore, Matthew M. Skinner, Lee R. Berger, Steven E. Churchill, Bernhard Zipfel, Tracy L. Kivell","doi":"10.1126/sciadv.adt1201","DOIUrl":"10.1126/sciadv.adt1201","url":null,"abstract":"<div >The evolution of the human hand is marked by a transition from a hand primarily used for locomotion to one primarily used for dexterous manipulation. The hand skeletons of Plio-Pleistocene hominins have different mosaics of human-like features associated with enhanced dexterity and ape-like features associated with locomotor hand use. However, the functional relevance of the ape-like features is debated, particularly due to a lack of complete and associated hand remains. Here, we investigate the internal phalangeal cortical structure of the nearly complete <i>Australopithecus sediba</i> MH2 hand and <i>Homo naledi</i> hand 1 to provide both insight into the manual behaviors of these fossil hominins and functional clarity regarding the mosaic features found within their hands. The phalangeal cortical structure demonstrates diversity in Plio-Pleistocene hand use, with <i>A. sediba</i> and <i>H. naledi</i> each indicating different dexterous abilities and different climbing strategies, supporting the functional importance of the ape-like features.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt1201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of dopaminergic medication and specific pathway alterations in idiopathic and PRKN/PINK1-mediated Parkinson’s disease 多巴胺能药物治疗和特定通路改变在特发性和PRKN/ pink1介导的帕金森病中的作用

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adp7063

Alexander Balck, Max Borsche, Philip Campbell, Xi Luo, John Harvey, Theresa Brückmann, Charlotte Ludwig, Amy Harms, Katja Lohmann, Emmeline Brown, Huw R. Morris, Anthony H. Schapira, Thomas Hankemeier, Ronan Fleming, Silke Szymczak, Christine Klein

{"title":"The role of dopaminergic medication and specific pathway alterations in idiopathic and PRKN/PINK1-mediated Parkinson’s disease","authors":"Alexander Balck, Max Borsche, Philip Campbell, Xi Luo, John Harvey, Theresa Brückmann, Charlotte Ludwig, Amy Harms, Katja Lohmann, Emmeline Brown, Huw R. Morris, Anthony H. Schapira, Thomas Hankemeier, Ronan Fleming, Silke Szymczak, Christine Klein","doi":"10.1126/sciadv.adp7063","DOIUrl":"10.1126/sciadv.adp7063","url":null,"abstract":"<div >Parkinson’s disease (PD) is the second most common neurodegenerative disease, with a rapidly increasing prevalence worldwide. Biomarkers monitoring state and progression are urgently needed, and metabolomics from easily accessible biofluids holds the potential to elucidate pathophysiological underpinnings in PD. Several studies suggested metabolomic differences between patients and controls, but findings are controversial, and independent replication is scarce. We thus applied state-of-the-art, large-scale metabolomics in patients with idiopathic and monogenic PD and controls from two independent samples, analyzed by a strict meta-analysis approach. Thereby, we (i) debunked that <span>l</span>-Dopa medication and not disease status causes the most substantial metabolomic differences and (ii) identified polyamine metabolism alterations, partly, but not entirely associated with <span>l</span>-Dopa treatment. Furthermore, we found explorative but robust evidence for alterations in endocannabinoid metabolites; detected lipid metabolism alterations, highlighting potential crosslinks with alpha-synuclein pathology; and provided evidence for a metabolomic signature for the role of oxidative damage in patients with <i>PRKN</i>- and <i>PINK1</i>-linked PD.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp7063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-cost robotic manipulation of live microtissues for cancer drug testing 用于癌症药物测试的活体显微组织的低成本机器人操作

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.ads1631

Ivan Stepanov, Noah R. Gottshall, Alireza Ahmadianyazdi, Daksh Sinha, Ethan J. Lockhart, Tran N. H. Nguyen, Sarmad Hassan, Lisa F. Horowitz, Raymond S. Yeung, Taranjit S. Gujral, Albert Folch

{"title":"Low-cost robotic manipulation of live microtissues for cancer drug testing","authors":"Ivan Stepanov, Noah R. Gottshall, Alireza Ahmadianyazdi, Daksh Sinha, Ethan J. Lockhart, Tran N. H. Nguyen, Sarmad Hassan, Lisa F. Horowitz, Raymond S. Yeung, Taranjit S. Gujral, Albert Folch","doi":"10.1126/sciadv.ads1631","DOIUrl":"10.1126/sciadv.ads1631","url":null,"abstract":"<div >The scarcity of human biopsies available for drug testing is a paramount challenge for developing therapeutics, disease models, and personalized treatments. Microtechnologies that combine the microscale manipulation of tissues and fluids offer the exciting possibility of miniaturizing both disease models and drug testing workflows on scarce human biopsies. Unfortunately, these technologies presently require microfluidic devices or robotic dispensers that are not widely accessible. We have rapidly prototyped an inexpensive platform based on an off-the-shelf robot that can microfluidically manipulate live microtissues into/out of culture plates without using complicated accessories such as microscopes or pneumatic controllers. The robot integrates complex functions with a simple, cost-effective, and compact construction, allowing placement inside a tissue culture hood for sterile workflows. We demonstrated a proof-of-concept cancer drug evaluation workflow of potential clinical utility using patient tumor biopsies with multiple drugs on 384-well plates. Our user-friendly, low-cost platform promises to make drug testing of microtissues broadly accessible to pharmaceutical, clinical, and biological laboratories.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads1631","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crustal to mantle melt storage during the evolution of Hawaiian volcanoes 夏威夷火山演化过程中地壳到地幔的融水储存

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adu9332

Esteban Gazel, Kyle Dayton, Wenwei Liang, Junlin Hua, Kendra J. Lynn, Julia E. Hammer

{"title":"Crustal to mantle melt storage during the evolution of Hawaiian volcanoes","authors":"Esteban Gazel, Kyle Dayton, Wenwei Liang, Junlin Hua, Kendra J. Lynn, Julia E. Hammer","doi":"10.1126/sciadv.adu9332","DOIUrl":"10.1126/sciadv.adu9332","url":null,"abstract":"<div >As the Pacific Plate migrates over the mantle plume below Hawaiʻi, magma flux decreases, resulting in changes in eruptive volume, style, and composition. It is thought that melt storage becomes deeper and ephemeral with the transition from highly voluminous tholeiitic (shield stage) to the less voluminous alkaline (post-shield and rejuvenation stages) magmatism. To quantitatively test this, we applied high-precision fluid inclusion barometry via Raman spectroscopy to samples from representative volcanoes of different evolutionary stages. This suggests an evolution from shield-stage shallow magma storage (~1 to 2 kilometers) for Kīlauea to a post-shield stage that includes crustal magma storage within the volcanic edifice (~2 kilometers) and deeper storage below the Moho (~20 to 27 kilometers) for Haleakalā. The rejuvenation stage (Diamond Head) displays mantle-dominated storage (~22 to 30 kilometers). High melt fluxes likely form stable conduits from the mantle to a shallow reservoir in the shield volcanoes. As melt flux decreases, the Moho becomes the boundary controlling melt stagnation and evolution.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu9332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of visible-wavelength aurora on Mars 探测火星上可见波长的极光

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.ads1563

Elise W. Knutsen, Timothy H. McConnochie, Mark Lemmon, Chris Donaldson, Raymond Francis, Carey Legett, Shayla B. Viet, Lauriane Soret, Daniel Toledo, Victor Apéstigue, Olivier Witasse, Franck Montmessin, Rebecca Jolitz, Nicolas M. Schneider, Leslie Tamppari, Agnès Cousin, Roger C. Wiens, Sylvestre Maurice, James F. Bell III, Olivier Forni, Jeremie Lasue, Paolo Pilleri, Tanguy Bertrand, Priya Patel, Susanne Schröder, Shannon Curry, Christina O. Lee, Ali Rahmati

{"title":"Detection of visible-wavelength aurora on Mars","authors":"Elise W. Knutsen, Timothy H. McConnochie, Mark Lemmon, Chris Donaldson, Raymond Francis, Carey Legett, Shayla B. Viet, Lauriane Soret, Daniel Toledo, Victor Apéstigue, Olivier Witasse, Franck Montmessin, Rebecca Jolitz, Nicolas M. Schneider, Leslie Tamppari, Agnès Cousin, Roger C. Wiens, Sylvestre Maurice, James F. Bell III, Olivier Forni, Jeremie Lasue, Paolo Pilleri, Tanguy Bertrand, Priya Patel, Susanne Schröder, Shannon Curry, Christina O. Lee, Ali Rahmati","doi":"10.1126/sciadv.ads1563","DOIUrl":"10.1126/sciadv.ads1563","url":null,"abstract":"<div >Mars hosts various auroral processes despite the planet’s tenuous atmosphere and lack of a global magnetic field. To date, all aurora observations have been at ultraviolet wavelengths from orbit. We describe the discovery of green visible-wavelength aurora, originating from the atomic oxygen line at 557.7 nanometers, detected with the SuperCam and Mastcam-Z instruments on the Mars 2020 Perseverance rover. Near–real-time simulations of a Mars-directed coronal mass ejection (CME) provided sufficient lead-time to schedule an observation with the rover. The emission was observed 3 days after the CME eruption, suggesting that the aurora was induced by particles accelerated by the moving shock front. To our knowledge, detection of aurora from a planetary surface other than Earth has never been reported, nor has visible aurora been observed at Mars. This detection demonstrates that auroral forecasting at Mars is possible, and that during events with higher particle precipitation, or under less dusty atmospheric conditions, aurorae will be visible to future astronauts.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads1563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global disparities in indoor wildfire-PM2.5 exposure and mitigation costs 室内野火- pm2.5暴露和缓解成本的全球差异

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.ads4360

Dongjia Han, Yongxuan Guo, Jianghao Wang, Bin Zhao

{"title":"Global disparities in indoor wildfire-PM2.5 exposure and mitigation costs","authors":"Dongjia Han, Yongxuan Guo, Jianghao Wang, Bin Zhao","doi":"10.1126/sciadv.ads4360","DOIUrl":"10.1126/sciadv.ads4360","url":null,"abstract":"<div >Wildfires have become more frequent and severe, and evidence showed that exposure to wildfire-caused PM<sub>2.5</sub> (fire-PM<sub>2.5</sub>) is associated with adverse health effects. Fire-PM<sub>2.5</sub> exposure occurs mainly indoors, where people spend most of their time. As an effective and timely approach of mitigating indoor PM<sub>2.5</sub> pollution, air purifiers incur notable associated costs. However, the long-term global population exposure to indoor fire-PM<sub>2.5</sub> and the economic burden of using air purifiers remain unknown. Here, we estimated the indoor fire-PM<sub>2.5</sub> concentration and the cost of reducing indoor PM<sub>2.5</sub> exposure, along with the extra cost incurred because of fire-PM<sub>2.5</sub>, at a resolution of 0.5° by 0.5° globally during 2003 to 2022. Our findings revealed 1009 million individuals exposed to at least one substantial indoor wildfire-air pollution day per year. We identified pronounced socioeconomic disparities in the costs of mitigating indoor PM<sub>2.5</sub> exposure, with low-income countries bearing a disproportionately higher economic burden, emphasizing the critical need for addressing these disparities.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads4360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0