Science Advances最新文献_第6页

ASPL couples the assembly of stress granules with their VCP-mediated disassembly ASPL将应力颗粒的组装与vcp介导的拆卸耦合在一起

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.ady3735

Gautam Pareek, Dongfang Li, Bo Wang, Jinjun Wu, Brian D. Freibaum, Joseph L. Basalla, Tharun Selvam Mahendran, Anurag Singh, Amanda Nourse, Honghu Quan, Ravi Kalathur, Mitra S. Rana, Brian Maxwell, Yong-Dong Wang, James Messing, Yonghui Ni, Stanley Pounds, Rachayata Dharmat, Jingjun Lu, Xiujie Li-Harms, Alexandre F. Carisey, Shondra M. Pruett-Miller, J. Paul Taylor, Priya Banerjee, Hong Joo Kim, Mondira Kundu

{"title":"ASPL couples the assembly of stress granules with their VCP-mediated disassembly","authors":"Gautam Pareek, Dongfang Li, Bo Wang, Jinjun Wu, Brian D. Freibaum, Joseph L. Basalla, Tharun Selvam Mahendran, Anurag Singh, Amanda Nourse, Honghu Quan, Ravi Kalathur, Mitra S. Rana, Brian Maxwell, Yong-Dong Wang, James Messing, Yonghui Ni, Stanley Pounds, Rachayata Dharmat, Jingjun Lu, Xiujie Li-Harms, Alexandre F. Carisey, Shondra M. Pruett-Miller, J. Paul Taylor, Priya Banerjee, Hong Joo Kim, Mondira Kundu","doi":"10.1126/sciadv.ady3735","DOIUrl":"10.1126/sciadv.ady3735","url":null,"abstract":"<div >Stress granules (SGs) are dynamic RNA-protein assemblies that form in response to cellular stress and must be efficiently disassembled to restore normal cell function. Valosin-containing protein (VCP), an enzyme implicated in neurodegenerative diseases, is essential for SG disassembly, but whether and how this process is coordinated with SG assembly remains unclear. Here, we identify the VCP cofactor, Alveolar soft part sarcoma locus (ASPL) as a key regulator linking SG assembly and disassembly. ASPL promotes SG assembly by facilitating biomolecular condensation of Ras guanosine triphosphatase–activating protein-binding protein (G3BP) and stabilizing its interactions with other SG proteins. ASPL also facilitates phosphorylation and activation of VCP by UNC-51-like kinases 1 and 2 (ULK1/2), enabling G3BP extraction and efficient SG disassembly. Pathogenic VCP mutations that disrupt ASPL binding impair SG disassembly, a defect rescued by phosphomimetic mutations or ASPL depletion. Our findings suggest that disruptions in the ASPL-VCP interaction uncouple SG assembly and disassembly, representing a potential mechanism underlying VCP-associated neurodegenerative diseases.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady3735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Earthquake frequency-magnitude distribution at Mount Etna sheds light on magma ascent in the volcano’s plumbing system 埃特纳火山的地震频率-震级分布揭示了火山管道系统中的岩浆上升

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.adx9873

Marco Firetto Carlino, Rosalia Lo Bue, Matteo Taroni, Mauro Coltelli, Flavio Cannavò, Ornella Cocina, Graziella Barberi, Luciano Scarfì

{"title":"Earthquake frequency-magnitude distribution at Mount Etna sheds light on magma ascent in the volcano’s plumbing system","authors":"Marco Firetto Carlino, Rosalia Lo Bue, Matteo Taroni, Mauro Coltelli, Flavio Cannavò, Ornella Cocina, Graziella Barberi, Luciano Scarfì","doi":"10.1126/sciadv.adx9873","DOIUrl":"10.1126/sciadv.adx9873","url":null,"abstract":"<div >Active volcanoes in densely populated areas are generally monitored through geological observations, geophysical, and geochemical data, which provide information on magma movement in the uppermost crust, allowing only short-term predictions of volcanic activity. However, deep magma recharge processes remain poorly understood. Here, we show that temporal variations in the slope of earthquake frequency-magnitude distribution (<i>b</i> value) at Mount Etna, a proxy for crustal stress changes, can track magma movements from deep to shallow crustal levels. Analyzing two decades of seismicity (2005–2024) across three crustal sectors, we distinguished magma recharge from the mantle, its transfer and storage at intermediate depths, and final ascent to the surface. Moreover, we found that <i>b</i> value time variations can precede geochemical anomalies from magma ascent and its eruption by a few months. Our results suggest that <i>b</i> value monitoring could have anticipated volcanic crises, supporting its integration into multiparametric surveillance systems for medium and long-term volcano monitoring.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx9873","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-dimensional shrinking electronics on freestanding and freeform curvilinear surfaces 在独立和自由曲面上的三维收缩电子学

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.aea8051

Yangbo Yuan, Dongliang Chen, Jianyu Li, Bowen Li, Abu Musa Abdullah, Fatema Tuz Zohra, Wanqing Zhang, Xianzhe Zhang, Xin Xin, Mohammad Ali Amidian, Ankan Dutta, Feifei Shi, Huanyu Cheng

引用次数: 0

Dust devil migration patterns reveal strong near-surface winds across Mars 尘暴的迁移模式揭示了火星上强烈的近地表风

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.adw5170

Valentin T. Bickel, Miguel Almeida, Matthew Read, Antonia Schriever, Daniela Tirsch, Ernst Hauber, Klaus Gwinner, Nicolas Thomas, Thomas Roatsch

{"title":"Dust devil migration patterns reveal strong near-surface winds across Mars","authors":"Valentin T. Bickel, Miguel Almeida, Matthew Read, Antonia Schriever, Daniela Tirsch, Ernst Hauber, Klaus Gwinner, Nicolas Thomas, Thomas Roatsch","doi":"10.1126/sciadv.adw5170","DOIUrl":"10.1126/sciadv.adw5170","url":null,"abstract":"<div >Dust devil migration is a direct expression of the dynamics of the lowermost martian atmosphere. These dynamics are responsible for dust lifting and atmospheric injection, a vital part of the dust cycle that governs modern Mars’ weather and climate. Here, we use deep learning and two decades’ worth of orbital images to track the global, diurnal, and seasonal migration patterns of dust devils across Mars, providing a distributed characterization of the dynamics of near-surface winds. Across Mars, derived wind stresses systematically exceed those predicted by global circulation models and frequently surpass the threshold required to initiate particle saltation and the lifting of dust. We identify instances of fast-moving dust devils, indicating strong near-surface winds, that are colocated with large-scale dust lifting events and storms. Our observations show that strong near-surface winds are abundant on Mars and play an important role in atmospheric dust sourcing, directly informing more accurate models of Mars’ atmosphere, weather, and climate.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw5170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ligand-receptor interactions induce and mediate regulatory functions of BATF3+ B cells 配体-受体相互作用诱导和介导BATF3 + B细胞的调节功能

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.adx9917

Hui Yan, Rui Wang, Suryavathi Viswanadhapalli, Christian Cervantes, Funan He, Shuai Wu, Azad Khosh, Weiwei Luo, Jingwei Wang, Maria J. Fernandez, Uday P. Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E. Rivera, Harshita B. Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R. Sareddy, Hong Zan, Yue Li, Exing Wang, Evelien M. Bunnik, Guangming Zhong, Christopher A. Hunter, Ross M. Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J. Curiel, Yan Xiang, Ratna K. Vadlamudi, Paolo Casali, Zhenming Xu

{"title":"Ligand-receptor interactions induce and mediate regulatory functions of BATF3+ B cells","authors":"Hui Yan, Rui Wang, Suryavathi Viswanadhapalli, Christian Cervantes, Funan He, Shuai Wu, Azad Khosh, Weiwei Luo, Jingwei Wang, Maria J. Fernandez, Uday P. Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E. Rivera, Harshita B. Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R. Sareddy, Hong Zan, Yue Li, Exing Wang, Evelien M. Bunnik, Guangming Zhong, Christopher A. Hunter, Ross M. Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J. Curiel, Yan Xiang, Ratna K. Vadlamudi, Paolo Casali, Zhenming Xu","doi":"10.1126/sciadv.adx9917","DOIUrl":"10.1126/sciadv.adx9917","url":null,"abstract":"<div >B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27–IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 interaction–mediated self-targeting, these cells promoted B cell PD-L1 expression and immune evasion. Mechanistically, <i>Il27</i> and <i>Cxcl10</i> transcription was induced by synergizing Toll-like receptor (TLR) and CD40 signals and driven by coinduced transcription factor BATF3, which directly targeted these genes. By applying a discovery framework focusing on regulatory cells, our findings expand the recognized scope of B cell regulatory functions.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx9917","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses 内源性p21水平通过抑制过量和受限的新生DNA合成来保护基因组的稳定性

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.adw4618

Nicolás L. Calzetta, Sabrina F. Mansilla, Candelaria Mares Ahlers, Agostina P. Bertolin, Lilen I. Caimi, Sofía Venerus Arbilla, Jingkun Zeng, Lisa Wiesmüller, Vanesa Gottifredi

{"title":"Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses","authors":"Nicolás L. Calzetta, Sabrina F. Mansilla, Candelaria Mares Ahlers, Agostina P. Bertolin, Lilen I. Caimi, Sofía Venerus Arbilla, Jingkun Zeng, Lisa Wiesmüller, Vanesa Gottifredi","doi":"10.1126/sciadv.adw4618","DOIUrl":"10.1126/sciadv.adw4618","url":null,"abstract":"<div >The rate of DNA synthesis is crucial for full DNA duplication. We report a key role of p21 in controlling this rate. During normal replication, p21 promotes nascent DNA synthesis alongside the DNA polymerase iota (Pol ι)/p53 complex. When p21 is down-regulated but detectable, nascent DNA tracks are longer and discontinuous and rely on primase and DNA polymerase (PrimPol). With the complete elimination of p21, nascent DNA tracks become shorter and continuous and depend on Pol kappa (κ). Endogenous p21 levels are critical for genomic stability, as both PrimPol- and Pol κ–mediated syntheses can induce chromosomal instability. The residual expression of p21 in p53-null cells influences the involvement of PrimPol or Pol κ in nascent DNA synthesis and subsequent chromosomal instability. Our results demonstrate that endogenous levels of p21 in cycling cells, insufficient for cyclin-dependent kinase inhibition, prevent genomic instability through proliferating cell nuclear antigen binding (PCNA), limiting PrimPol and Pol κ’s role in nascent DNA synthesis.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw4618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stiffness reprogrammable magnetorheological metamaterials inspired by spine for multibit visual mechanical information processing 基于脊柱的多比特视觉机械信息处理的刚度可编程磁流变超材料

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.ady8430

Congcong Lou, Xinyu Lian, Huaxia Deng, Bing Liu, Shilong Duan, Yunpu Zhao, Xinglong Gong

{"title":"Stiffness reprogrammable magnetorheological metamaterials inspired by spine for multibit visual mechanical information processing","authors":"Congcong Lou, Xinyu Lian, Huaxia Deng, Bing Liu, Shilong Duan, Yunpu Zhao, Xinglong Gong","doi":"10.1126/sciadv.ady8430","DOIUrl":"10.1126/sciadv.ady8430","url":null,"abstract":"<div >Embedding information processing into mechanical metamaterials is conductive to constructing multifunctional mechanical systems, which has unique advantages to provide information processing platforms in extreme environments. However, achieving high-density, reprogrammable, and visually readable information processing in most mechanical metamaterials remains a challenge. Here, we report a multibit programming spine structure strategy to create a magnetorheological metamaterial with high-density, reprogrammable, and visually readable information encoding capacities. Inspired by spine features, the magnetorheological spine beams, exhibiting substantial stiffness variation by bistable transition, meticulously conceived the stiffness reprogrammable magnetorheological metamaterial (SRMM). The SRMM exhibits a large stiffness conversion capability (40-fold) and high-density information encoding performance (10-bit). Coupling with the mechanoluminescent materials, the mechanical information achieves visualization conveniently, which is attributed to the conversion of the stiffness data into optical signals through optical energy level transitions. Such stiffness-based magnetorheological metamaterial offers expansive information encoding spaces, stable operation capabilities, and convenient readout approaches, advancing mechanical information processing system design for extreme environments.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady8430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in C. elegans 通过碱化秀丽隐杆线虫的一对胶质细胞，ClC阴离子通道的缺失增加了寿命、健康寿命和抗逆性

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.ady1027

Lei Wang, Enrique I. Oliver, Dario L. D’Urso, Bianca Graziano, Laura Bianchi

引用次数: 0

Photoactivatable immunostimulatory nanoengineered microalgae for boosting cascade-activated antitumor immunity 光激活免疫刺激纳米微藻增强级联激活抗肿瘤免疫

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.adw4212

Shuiling Chen, Ming Li, Yu Zhang, Yushu Dong, Jinying Wu, Lixiang Li, Xing Guo, Xia Liu, Jianwen Hou, Shaobing Zhou

{"title":"Photoactivatable immunostimulatory nanoengineered microalgae for boosting cascade-activated antitumor immunity","authors":"Shuiling Chen, Ming Li, Yu Zhang, Yushu Dong, Jinying Wu, Lixiang Li, Xing Guo, Xia Liu, Jianwen Hou, Shaobing Zhou","doi":"10.1126/sciadv.adw4212","DOIUrl":"10.1126/sciadv.adw4212","url":null,"abstract":"<div >Limited tumor immunogenicity and the profoundly immunosuppressive tumor microenvironment (TME) pose major challenges to effective cancer immunotherapy. Herein, we present a photoactivatable immunostimulator based on nanoengineered microalgae (PCC@AuNP) to simultaneously enhance tumor immunogenicity and remodel the TME. Mechanistically, photocatalytically generated hydrogen induces robust immunogenic cell death by triggering severe endoplasmic reticulum stress and mitochondrial dysfunction. Concurrently, photosynthetic oxygen production and photocatalytic lactic acid depletion collaboratively alleviate immunosuppression within the TME, thereby enhancing cytotoxic T lymphocyte activity by reducing the infiltration of immunosuppressive cells and promoting the repolarization of tumor-associated macrophages from the M2 to the M1 phenotype. In vivo studies demonstrate that PCC@AuNP not only eradicates primary tumors but also elicits potent systemic antitumor immunity against distant lesions, without observable toxicity to healthy tissues. Collectively, this innovative PCC@AuNP platform offers a safe and effective therapeutic strategy, heralding a pioneering era of cascade-augmented gas-driven cancer immunotherapy with superior precision and biosafety.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw4212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generating theranostic bacteria by depositing a protective visual therapeutic nanocoating via in situ sequential mineralization 通过原位顺序矿化沉积保护性视觉治疗纳米涂层，产生治疗性细菌

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-10-08 DOI: 10.1126/sciadv.ady9183

Shixiong Chen, Beibei Sun, Lingling Lin, Xinxin Zhao, Yan Zhou, Feng Wu, Huilin Zhao, Jinyao Liu

{"title":"Generating theranostic bacteria by depositing a protective visual therapeutic nanocoating via in situ sequential mineralization","authors":"Shixiong Chen, Beibei Sun, Lingling Lin, Xinxin Zhao, Yan Zhou, Feng Wu, Huilin Zhao, Jinyao Liu","doi":"10.1126/sciadv.ady9183","DOIUrl":"10.1126/sciadv.ady9183","url":null,"abstract":"<div >Oral bacteriotherapy is increasingly exploited but faces challenges in simultaneously monitoring treatment process and achieving desirable efficacy. Here, we develop theranostic bacteria by depositing a protective visual therapeutic nanocoating via in situ sequential mineralization. Using two-step metal ion adsorption and nucleation, bacterial surface is successively mineralized with an inner manganese dioxide/ferric oxide nanoparticle layer and an outer calcium carbonate layer. Upon ingestion, the outer layer neutralizes gastric acid through double-decomposition reaction, protecting bacterial viability and the inner layer. During intestinal passage, the inner layer enables T1/T2 dual-mode magnetic resonance imaging for real-time tracking, whereas the lesion-triggered release of manganese ions allows T1 single-mode pathological detection. The inner layer also exhibits superoxide dismutase and catalase activities, synergizing therapeutic effects with bacteria. Further supported by satisfactory performances in two murine models of <i>Salmonella</i>-induced colitis and apolipoprotein E–deficient atherosclerosis, this work provides a platform to generate innovative theranostic agents for advanced bacteriotherapy.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady9183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0