Science Advances最新文献_第6页

Mechanism of high-temperature superconductivity in compressed H2-molecular–type hydride

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adt9411

Pengye Liu, Quan Zhuang, Qiang Xu, Tian Cui, Zhao Liu

{"title":"Mechanism of high-temperature superconductivity in compressed H2-molecular–type hydride","authors":"Pengye Liu, Quan Zhuang, Qiang Xu, Tian Cui, Zhao Liu","doi":"10.1126/sciadv.adt9411","DOIUrl":"10.1126/sciadv.adt9411","url":null,"abstract":"<div >The discovery of compressed atomic-type hydrides offers a promising avenue toward achieving room-temperature superconductivity, but it necessitates extremely high pressures to completely dissociate hydrogen molecules to release free electrons. Here, we report a remarkable finding of compressed H<sub>2</sub>-molecular–type hydride CaH<sub>14</sub> exhibiting an unusual transition temperature (<i>T</i><sub>c</sub>) of 204.0 kelvin. The peculiarity of its electronic structure lies in the pronounced emergence of near-free electrons, which manifest metallic bonding, but molecular hydrogen fragments persist. This finding indicates that the necessary condition for superconducting transition is forming the Fermi sea with Cooper pairs rather than the monatomic hydrogen. Notably, the formation mechanism of free electrons can be effectively explained by the finite-depth potential wells model. Intriguingly, this H<sub>2</sub>-molecular–type hydride can downgrade the required pressure to 80 gigapascal while maintaining a high <i>T</i><sub>c</sub> of 84 kelvin, well above the liquid-nitrogen temperature. Our study has established a high-temperature superconducting paradigm and opened the prospect for achieving high-<i>T</i><sub>c</sub> superconductors in H<sub>2</sub>-molecular–type hydrides at low pressure.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt9411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steroid hormone levels vary with sex, aging, lifestyle, and genetics

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adu6094

Léa G. Deltourbe, Jamie Sugrue, Elizabeth Maloney, Florian Dubois, Anthony Jaquaniello, Jacob Bergstedt, Etienne Patin, Lluis Quintana-Murci, Molly A. Ingersoll, Darragh Duffy, Milieu Intérieur Consortium

{"title":"Steroid hormone levels vary with sex, aging, lifestyle, and genetics","authors":"Léa G. Deltourbe, Jamie Sugrue, Elizabeth Maloney, Florian Dubois, Anthony Jaquaniello, Jacob Bergstedt, Etienne Patin, Lluis Quintana-Murci, Molly A. Ingersoll, Darragh Duffy, Milieu Intérieur Consortium","doi":"10.1126/sciadv.adu6094","DOIUrl":"10.1126/sciadv.adu6094","url":null,"abstract":"<div >Steroid hormone levels vary greatly among individuals, between sexes, with age, and across health and disease. What drives variance in steroid hormones and how they vary in individuals over time are not well studied. To address these questions, we measured 17 steroid hormones in a sex-balanced cohort of 949 healthy donors aged 20 to 69 years. We investigated associations between steroid levels and biological sex, age, clinical and demographic data, genetics, and plasma proteomics. Steroid hormone levels were strongly affected by sex and age, and a high number of lifestyle habits. Key observations were the broad impact of hormonal birth control in female donors and the relationship with smoking in male donors. In a 10-year follow-up study, we identified significant associations between steroid hormone levels and health status only in male donors. These observations highlight biological and lifestyle parameters affecting steroid hormones, and underlie the importance of considering sex, age, and potentially gendered behaviors in the treatment of hormone-related diseases.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu6094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perturbed cell fate decision by schizophrenia-associated AS3MTd2d3 isoform during corticogenesis

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adp8271

Seunghyun Kim, Youngsik Woo, Dahun Um, Inseop Chun, Su-Jin Noh, Hyeon Ah Ji, Namyoung Jung, Bon Seong Goo, Jin Yeong Yoo, Dong Jin Mun, Tran Diem Nghi, Truong Thi My Nhung, Seung Hyeon Han, Su Been Lee, Wonhyeok Lee, Jonghyeok Yun, Ki Hurn So, Dae-Kyum Kim, Hyunsoo Jang, Yeongjun Suh, Jong-Cheol Rah, Seung Tae Baek, Ki-Jun Yoon, Min-Sung Kim, Tae-Kyung Kim, Sang Ki Park

{"title":"Perturbed cell fate decision by schizophrenia-associated AS3MTd2d3 isoform during corticogenesis","authors":"Seunghyun Kim, Youngsik Woo, Dahun Um, Inseop Chun, Su-Jin Noh, Hyeon Ah Ji, Namyoung Jung, Bon Seong Goo, Jin Yeong Yoo, Dong Jin Mun, Tran Diem Nghi, Truong Thi My Nhung, Seung Hyeon Han, Su Been Lee, Wonhyeok Lee, Jonghyeok Yun, Ki Hurn So, Dae-Kyum Kim, Hyunsoo Jang, Yeongjun Suh, Jong-Cheol Rah, Seung Tae Baek, Ki-Jun Yoon, Min-Sung Kim, Tae-Kyung Kim, Sang Ki Park","doi":"10.1126/sciadv.adp8271","DOIUrl":"10.1126/sciadv.adp8271","url":null,"abstract":"<div >The neurodevelopmental theory of schizophrenia emphasizes early brain development in its etiology. Genome-wide association studies have linked schizophrenia to genetic variations of <i>AS3MT</i> (arsenite methyltransferase) gene, particularly the increased expression of AS3MT<sup>d2d3</sup> isoform. To investigate the biological basis of this association with schizophrenia pathophysiology, we established a transgenic mouse model (AS3MT<sup>d2d3</sup>-Tg) ectopically expressing AS3MT<sup>d2d3</sup> at the cortical neural stem cells. AS3MT<sup>d2d3</sup>-Tg mice exhibited enlarged ventricles and deficits in sensorimotor gating and sociability. Single-cell and single-nucleus RNA sequencing analyses of AS3MT<sup>d2d3</sup>-Tg brains revealed cell fate imbalances and altered excitatory neuron composition. AS3MT<sup>d2d3</sup> localized to centrosome, disrupting mitotic spindle orientation and differentiation in developing neocortex and organoids, in part through NPM1 (Nucleophosmin 1). The structural analysis identified that hydrophobic residues exposed in AS3MT<sup>d2d3</sup> are critical for its pathogenic function. Therefore, our findings may help to explain the early pathological features of schizophrenia.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp8271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational capacity of life in relation to the universe

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adt4623

Philip Kurian

{"title":"Computational capacity of life in relation to the universe","authors":"Philip Kurian","doi":"10.1126/sciadv.adt4623","DOIUrl":"10.1126/sciadv.adt4623","url":null,"abstract":"<div >As physical systems, all life in the universe processes information according to physical laws. Estimates for the computational capacity of living systems generally assume that the fundamental information-processing unit is the Hodgkin-Huxley neuron, thereby excluding aneural organisms. Assuming the laws of quantum mechanics, the relativistic speed limit set by light, a universe at critical mass-energy density, and a recent experimental demonstration of single-photon superradiance in cytoskeletal protein fibers at thermal equilibrium, it is conjectured that the number of elementary logical operations that can have been performed by all eukaryotic life in the history of Earth, which is shown to be approximately equal to the ratio of the age of the universe to the Planck time, is about the square root of the number by the entire observable universe from the beginning. The existence of ultraviolet-excited <span><math><mrow><mrow><mo>∣</mo><mspace></mspace><mi>W</mi><mspace></mspace><mo>〉</mo></mrow></mrow></math></span> states in these protein fibers, operating within two orders of magnitude of the Margolus-Levitin speed limit, motivates state-of-the-art performance comparisons with contemporary quantum computers.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt4623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophoretic digital colorimetry integrated with electrochemical sweat sensor

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adu2142

Daeun Sung, Seunghun Han, Sumin Kim, Heeseok Kang, Bon Jekal, Giheon Kim, Jaewon Kim, Minki Hong, Gyounghwan Moon, Sungeun Kim, Yerim Lee, Suk-Won Hwang, Hyoyoung Jeong, Yong-Sang Ryu, Sungbong Kim, Jahyun Koo

{"title":"Electrophoretic digital colorimetry integrated with electrochemical sweat sensor","authors":"Daeun Sung, Seunghun Han, Sumin Kim, Heeseok Kang, Bon Jekal, Giheon Kim, Jaewon Kim, Minki Hong, Gyounghwan Moon, Sungeun Kim, Yerim Lee, Suk-Won Hwang, Hyoyoung Jeong, Yong-Sang Ryu, Sungbong Kim, Jahyun Koo","doi":"10.1126/sciadv.adu2142","DOIUrl":"10.1126/sciadv.adu2142","url":null,"abstract":"<div >Recent advancements in wearable sweat sensors, which use standardized electrochemical and colorimetric mechanisms, offer holistic representation of health status for users. However, the constraints of standardized sweat sensors present ongoing challenges to realization of personalized health management. This study presents an electrocolorimetric (EC) platform that enables the reversible and multiple-time use of colorimetric data visualization using electrophoretic display (EPD). This platform represents the application of low-power EPD in epidermal sweat sensor, evaluated through CIELAB-based methodology which is the first systematic evaluation tool of wearable display performance. Moreover, our platform has been demonstrated in human exercise trials for its ability to detect the lactate threshold (LT). This digital colorimetric system has the potential to play a pivotal role by integrating various health monitoring biomarkers. While providing real-time, continuous, and adjustable range information with high sensitivity, this platform validates its extensive probability as a next-generation wearable epidermal sensor.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu2142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WWC1 mutation drives dopamine dysregulation and synaptic imbalance in Tourette’s syndrome

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adr4588

Junkai Lv, Shiqi Liang, Pengwei Qin, Xinlu Liu, Xiangyu Ge, Yiqing Guo, Shili Xia, Wei Jing, Youming Lu, Tongmei Zhang, Hao Li

{"title":"WWC1 mutation drives dopamine dysregulation and synaptic imbalance in Tourette’s syndrome","authors":"Junkai Lv, Shiqi Liang, Pengwei Qin, Xinlu Liu, Xiangyu Ge, Yiqing Guo, Shili Xia, Wei Jing, Youming Lu, Tongmei Zhang, Hao Li","doi":"10.1126/sciadv.adr4588","DOIUrl":"10.1126/sciadv.adr4588","url":null,"abstract":"<div >Tourette’s syndrome (TS) is a major neurodevelopmental disorder characterized by childhood-onset motor and vocal tics. A W88C mutation in <i>WWC1</i> gene is a notable risk factor for TS, but the underlying molecular mechanisms remain unclear due to the lack of suitable animal models. Here, we generate a mutant mouse line with human W88C mutation (W88C<sup>Mut</sup> mice), which exhibits behavioral deficits similar to those observed in patients with TS, including repetitive motor behaviors and sensorimotor gating abnormalities. The W88C mutation leads to the degradation of kidney and brain (KIBRA) protein via a proteasomal pathway, evokes dopamine release in the dorsal striatum, and disrupts synaptic function through the dysregulation of Hippo pathway. Neuron-specific overexpression of wild-type <i>WWC1</i> rescues synaptic and behavioral phenotypes in W88C<sup>Mut</sup> mice. Together, this study not only provides a valuable mouse model for studying TS but also offers fresh insights into the molecular and synaptic mechanisms underlying neurodevelopmental abnormalities in TS.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr4588","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.ads2086

Delia Ricolo, Jordi Casanova, Panagiotis Giannios

引用次数: 0

Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.ads6573

Brendan McKee, Samere Abolghasemzade, Ting-Ching Wang, Kajol Harsh, Simran Kaur, Ryan Blanchard, Krishna Belraj Menon, Mohammad Mohajeri, Richard B. Dickinson, Tanmay P. Lele

{"title":"Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions","authors":"Brendan McKee, Samere Abolghasemzade, Ting-Ching Wang, Kajol Harsh, Simran Kaur, Ryan Blanchard, Krishna Belraj Menon, Mohammad Mohajeri, Richard B. Dickinson, Tanmay P. Lele","doi":"10.1126/sciadv.ads6573","DOIUrl":"10.1126/sciadv.ads6573","url":null,"abstract":"<div >Cell migration through narrow spaces is essential in wound healing and metastatic spread of cancer. Cells must deform the large nucleus to fit through constricting channels. To understand the role of the nuclear lamina in limiting cell migration through constrictions, we imaged it in cells migrating through periodic constricting channels in a microdevice. The lamina underwent cycles of wrinkling and smoothing as the nucleus changed from an irregular, rounded shape in the wide channel regions between constrictions to a smooth, hourglass shape as the nucleus passed through the center of a constriction. The laminar surface area of nuclei within constrictions was measured to be at or above the computationally predicted threshold area for the nuclear volume. The channels excluded control nuclei that had insufficient excess surface area, but not nuclei lacking lamin A/C. Thus, the excess surface area of the nuclear lamina enables cell migration through constricting channels.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads6573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural basis for the pore-forming activity of a complement-like toxin

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adt2127

Bronte A. Johnstone, Michelle P. Christie, Riya Joseph, Craig J. Morton, Hamish G. Brown, Eric Hanssen, Tristan C. Sanford, Hunter L. Abrahamsen, Rodney K. Tweten, Michael W. Parker

{"title":"Structural basis for the pore-forming activity of a complement-like toxin","authors":"Bronte A. Johnstone, Michelle P. Christie, Riya Joseph, Craig J. Morton, Hamish G. Brown, Eric Hanssen, Tristan C. Sanford, Hunter L. Abrahamsen, Rodney K. Tweten, Michael W. Parker","doi":"10.1126/sciadv.adt2127","DOIUrl":"10.1126/sciadv.adt2127","url":null,"abstract":"<div >Pore-forming proteins comprise a highly diverse group of proteins exemplified by the membrane attack complex/perforin (MACPF), cholesterol-dependent cytolysin (CDC), and gasdermin superfamilies, which all form gigantic pores (>150 angstroms). A recently found family of pore-forming toxins, called CDC-like proteins (CDCLs), are wide-spread in gut microbes and are a prevalent means of antibacterial antagonism. However, the structural aspects of how CDCLs assemble a pore remain a mystery. Here, we report the crystal structure of a proteolytically activated CDCL and cryo–electron microscopy structures of a prepore-like intermediate and a transmembrane pore providing detailed snapshots across the entire pore-forming pathway. These studies reveal a sophisticated array of regulatory features to ensure productive pore formation, and, thus, CDCLs straddle the MACPF, CDC, and gasdermin lineages of the giant pore superfamilies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt2127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-03-28 DOI: 10.1126/sciadv.adu1710

Andrey A. Parkhitko, Valentin Cracan

{"title":"Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases","authors":"Andrey A. Parkhitko, Valentin Cracan","doi":"10.1126/sciadv.adu1710","DOIUrl":"10.1126/sciadv.adu1710","url":null,"abstract":"<div >Metabolic dysregulation represents one of the major driving forces in aging. Although multiple genetic and pharmacological manipulations are known to extend longevity in model organisms, aging is a complex trait, and targeting one’s own genes may be insufficient to prevent age-dependent deterioration. An alternative strategy could be to use enzymes from other species to reverse age-associated metabolic changes. In this review, we discuss a set of enzymes from lower organisms that have been shown to affect various metabolic parameters linked to age-related processes. These enzymes include modulators of steady-state levels of amino acids (METase, ASNase, and ADI), NADPH/NADP<sup>+</sup> and/or reduced form of coenzyme Q (CoQH<sub>2</sub>)/CoQ redox potentials (NDI1, AOX, <i>Lb</i>NOX, TPNOX, <i>Ec</i>STH, RquA, LOXCAT, Grubraw, and ScURA), GSH (StGshF), mitochondrial membrane potential (mtON and mito-dR), or reactive oxygen species (DAAO and KillerRed-SOD1). We propose that leveraging non-mammalian enzymes represents an untapped resource that can be used to delay aging and age-related diseases.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 13","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu1710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0