Science Advances最新文献_第5页

Broadband and efficient third-harmonic generation from black phosphorus–hybrid plasmonic metasurfaces in the mid-infrared 中红外黑磷混合等离子体超表面宽带高效三次谐波产生

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adt3772

Song Zhu, Wenduo Chen, Tugba Temel, Fakun Wang, Xiaodong Xu, Ruihuan Duan, Tingting Wu, Xuan Mao, Congliao Yan, Jianbo Yu, Chongwu Wang, Yuhao Jin, Jieyuan Cui, Jinghao Li, Dora Juan Juan Hu, Zheng Liu, Robert T. Murray, Yu Luo, Qi Jie Wang

{"title":"Broadband and efficient third-harmonic generation from black phosphorus–hybrid plasmonic metasurfaces in the mid-infrared","authors":"Song Zhu, Wenduo Chen, Tugba Temel, Fakun Wang, Xiaodong Xu, Ruihuan Duan, Tingting Wu, Xuan Mao, Congliao Yan, Jianbo Yu, Chongwu Wang, Yuhao Jin, Jieyuan Cui, Jinghao Li, Dora Juan Juan Hu, Zheng Liu, Robert T. Murray, Yu Luo, Qi Jie Wang","doi":"10.1126/sciadv.adt3772","DOIUrl":"10.1126/sciadv.adt3772","url":null,"abstract":"<div >Black phosphorus (BP), with a mid-infrared (MIR) bandgap of 0.34 eV, presents itself as a promising material for MIR nonlinear optical applications. We report the realization of MIR third-harmonic generation (THG) in both BP and BP-hybrid plasmonic metasurfaces (BPM). BP exhibits a high third-order nonlinear susceptibility (<span><math><mrow><msup><mi>χ</mi><mrow><mo>(</mo><mn>3</mn><mo>)</mo></mrow></msup></mrow></math></span>) exceeding 10<sup>−18</sup> m<sup>2</sup>/V<sup>2</sup> in the MIR region with a maximum value of 1.55 × 10<sup>−17</sup> m<sup>2</sup>/V<sup>2</sup> at 5000 nm. The BP flake achieves a THG conversion efficiency of 1.4 × 10<sup>−5</sup>, surpassing that of other 2D materials by over one order of magnitude. To further enhance this nonlinear performance, a BPM is designed and fabricated to achieve a two-order-of-magnitude enhancement in THG, leading to a record conversion efficiency of 6.5 × 10<sup>−4</sup>, exceeding the performance of previously reported metasurfaces by more than one order of magnitude. These findings establish BP as a promising platform for next-generation MIR nonlinear optical devices.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt3772","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A roadmap for safe, regulation-compliant Living Labs for AI and digital health development 为人工智能和数字健康发展制定安全、符合法规的生活实验室路线图

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adv7719

Stephen Gilbert, Rebecca Mathias, Anett Schönfelder, Magdalena Wekenborg, Julia Steinigen-Fuchs, Anja Dillenseger, Tjalf Ziemssen

引用次数: 0

Identification and characterization of the de novo methyltransferases for eukaryotic N6-methyladenine (6mA) 真核n6 -甲基腺嘌呤（6mA）从头甲基转移酶的鉴定与表征

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adq4623

Ting Cheng, Jiachen Zhang, Haicheng Li, Jinghan Diao, Wenxin Zhang, Junhua Niu, Takayuki Kawaguchi, Jun-ichi Nakayama, Kensuke Kataoka, Shan Gao

{"title":"Identification and characterization of the de novo methyltransferases for eukaryotic N6-methyladenine (6mA)","authors":"Ting Cheng, Jiachen Zhang, Haicheng Li, Jinghan Diao, Wenxin Zhang, Junhua Niu, Takayuki Kawaguchi, Jun-ichi Nakayama, Kensuke Kataoka, Shan Gao","doi":"10.1126/sciadv.adq4623","DOIUrl":"10.1126/sciadv.adq4623","url":null,"abstract":"<div ><i>N</i><sup>6</sup>-methyladenine (6mA) is an intensively investigated epigenetic modification in eukaryotes. 6mA is maintained through semiconservative transmission during DNA replication, but the identity of de novo methyltransferase (MTase) catalyzing its establishment remains unknown. Here, we identified MT-A70 family proteins AMT2 and AMT5 as the de novo MTases responsible for 6mA establishment, using the unique sexual reproduction process of the unicellular eukaryote <i>Tetrahymena thermophila</i>. Deletion of <i>AMT2</i> and <i>AMT5</i> led to a substantial decrease in 6mA levels in the progeny macronucleus, resulting in an altered gene expression pattern and a substantial decline in the survival rate of sexual progenies. Additionally, the maintenance MTase AMT1 could exhibit a much diminished de novo methylation activity in cells lacking AMT2 and AMT5. Our study delineated the establishment-maintenance pathway of 6mA and underscored the biological importance of de novo methylation, revealing a notable parallel between 6mA and the classical 5-methylcytosine in eukaryotes.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq4623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant cell–inspired colon-targeted cargo delivery systems with dual-triggered release mechanisms 具有双触发释放机制的植物细胞启发结肠靶向货物输送系统

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adt2653

Anran Mao, Anna C. Gebhard, Nazanin Z. Ezazi, Aseem Salhotra, Anastasia V. Riazanova, Ravi Shanker, Lars Wågberg, Line Hagner Nielsen, Anna J. Svagan

{"title":"Plant cell–inspired colon-targeted cargo delivery systems with dual-triggered release mechanisms","authors":"Anran Mao, Anna C. Gebhard, Nazanin Z. Ezazi, Aseem Salhotra, Anastasia V. Riazanova, Ravi Shanker, Lars Wågberg, Line Hagner Nielsen, Anna J. Svagan","doi":"10.1126/sciadv.adt2653","DOIUrl":"10.1126/sciadv.adt2653","url":null,"abstract":"<div >Plant cells represent smart cargo carriers with great socioeconomic potential in oral drug delivery applications. The two exterior barriers, featuring a rigid cell wall and a dense plasma membrane, are unique with complementary structural, mechanical, and chemical properties. Current strategies for producing therapeutic drugs within plant cells for oral delivery are efficient, but largely limited to recombinant pharmaceutical proteins, and involve complex genetic modification of plants. To address this, we engineer plant cell–inspired delivery systems with cellulose nanofiber–based shells and lipid layers through a bottom-up assembly strategy, which offers greater flexibility to encapsulate nonprotein compounds and nanoparticles. Notably, the layered shell structure resists degradation in acidic environments, and two barriers respond differently to external stimuli in simulated gastrointestinal medium, resulting in size-dependent dual-triggered release mechanisms. The cytocompatibility was shown by incubation with Caco-2 cells. Our results open avenues for developing next generation of bioinspired oral delivery systems for multisite-specific gastrointestinal release in a low-cost and sustainable manner.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt2653","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal focused ultrasound lesion location in essential tremor 特发性震颤的最佳超声病灶定位

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adp0532

Melissa M. J. Chua, Alfredo Morales Pinzon, Clemens Neudorfer, Patrick R. Ng, Sarah E. Blitz, Garance M. Meyer, Konstantin Butenko, Till A. Dembek, Alexandre Boutet, Andrew Z. Yang, Michael Schwartz, Jürgen Germann, Nir Lipsman, Andres Lozano, Fardad Behzadi, Nathan J. McDannold, John D. Rolston, Charles R. G. Guttmann, Michael D. Fox, G. Rees Cosgrove, Andreas Horn

{"title":"Optimal focused ultrasound lesion location in essential tremor","authors":"Melissa M. J. Chua, Alfredo Morales Pinzon, Clemens Neudorfer, Patrick R. Ng, Sarah E. Blitz, Garance M. Meyer, Konstantin Butenko, Till A. Dembek, Alexandre Boutet, Andrew Z. Yang, Michael Schwartz, Jürgen Germann, Nir Lipsman, Andres Lozano, Fardad Behzadi, Nathan J. McDannold, John D. Rolston, Charles R. G. Guttmann, Michael D. Fox, G. Rees Cosgrove, Andreas Horn","doi":"10.1126/sciadv.adp0532","DOIUrl":"10.1126/sciadv.adp0532","url":null,"abstract":"<div >Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is an effective treatment for medically refractory essential tremor. We investigate ablation sites and potential tracts associated with optimal tremor control and side effects based on the analysis of 351 cases from three international hospitals. Lesions were segmented on day 1 thin-cut T2 axial images, mapped to standard Montreal Neurological Institute space, and used to derive probabilistic maps and tracts associated with tremor improvement and side effects. Lesioning of a specific subregion within the ventral intermediate nucleus and the cerebellothalamic tract was associated with optimal tremor improvements. Some lesion locations and tracts were associated with differential side effects. Overlaps with the optimal tremor improvement sites accounted for variance in clinical improvements in out-of-sample cases. Efficacy of this location was further confirmed by test-retest cases that underwent two MRgFUS procedures. We identify and validate a target area for optimal tremor control and sites of avoidance associated with side effects.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp0532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introducing the “other” type of DNA methylation 介绍“其他”类型的DNA甲基化

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adx6879

Matthias Bochtler

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A spectrum of tectonic processes at coronae on Venus revealed by gravity and topography 由重力和地形揭示的金星日冕构造过程的光谱

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adt5932

Gael Cascioli, Anna J. P. Gülcher, Erwan Mazarico, Suzanne E. Smrekar

{"title":"A spectrum of tectonic processes at coronae on Venus revealed by gravity and topography","authors":"Gael Cascioli, Anna J. P. Gülcher, Erwan Mazarico, Suzanne E. Smrekar","doi":"10.1126/sciadv.adt5932","DOIUrl":"10.1126/sciadv.adt5932","url":null,"abstract":"<div >Coronae on Venus are key to understanding the planet’s geodynamics. Their formation is often linked to plume-lithosphere interactions, with some coronae showing signs of plate boundary-like processes such as subduction. However, the low resolution of Venus gravity data limits detailed analysis of these features. Using 3D geodynamic models, we predict gravity signals under various plume-induced corona formation scenarios. Comparing these predictions to observations, we show that combining topography and gravity data is more effective for understanding dynamic processes than using topography alone. Of the 75 resolved coronae, gravity indicates buoyant mantle material beneath 52. We predict a range of plume-lithosphere interactions and activity stages across these coronae. Moreover, we find that the limited resolution of the Magellan gravity field can obscure gravity signatures otherwise indicative of plume activity. The upcoming VERITAS mission will greatly improve gravity resolution, which will resolve 427 coronae, enhancing our understanding of Venus’ lithospheric structure and geodynamics.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt5932","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pixelation of perovskite quantum wire thin films with 0.18-μm features and 63,500-ppi pixel density 0.18-μm特征和63,500-ppi像素密度的钙钛矿量子线薄膜的像素化

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adu3840

Qianpeng Zhang, Xiaofei Sun, Guanyu Chen, Zichao Ma, Daquan Zhang, Yu Zhou, Xiao Qiu, Beitao Ren, Yucheng Ding, Swapnadeep Poddar, Wenying Tang, Hualiang Lv, Xiaoliang Mo, Zhiyong Fan

{"title":"Pixelation of perovskite quantum wire thin films with 0.18-μm features and 63,500-ppi pixel density","authors":"Qianpeng Zhang, Xiaofei Sun, Guanyu Chen, Zichao Ma, Daquan Zhang, Yu Zhou, Xiao Qiu, Beitao Ren, Yucheng Ding, Swapnadeep Poddar, Wenying Tang, Hualiang Lv, Xiaoliang Mo, Zhiyong Fan","doi":"10.1126/sciadv.adu3840","DOIUrl":"10.1126/sciadv.adu3840","url":null,"abstract":"<div >Halide perovskite materials excel in broad optoelectronic applications, and there is an urgent demand to develop perovskite-based integrated optoelectronic devices. However, the limitations posed by the incompatibility of perovskite thin film with wet lithography greatly hinder its potential in many important applications, including ultrahigh-density displays, high-resolution image sensors, high-density memristors, and integrated photonic circuitry. To tackle this bottleneck problem, we develop the self-aligned close-spaced sublimation growth of perovskite quantum wires and demonstrate 0.18-micrometer feature size perovskite patterns, meanwhile achieving a pixel density of 63,500 pixels per inch, the highest reported for perovskite. We showcase pixelation of perovskite quantum wires with color conversion films, addressing the need for full-color microdisplays. In addition, we demonstrate these films on curved substrates, holding promise for near-eye microdisplays. Processes shown here can also apply to other perovskite devices such as high-resolution displays, image sensing, and memristor arrays.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu3840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress-engineered ultra-broadband spectrometers 应力工程超宽带光谱仪

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adu4225

Gongyuan Zhang, Tom Albrow-Owen, Wenjun Peng, Xin Liang, Xianming Zhang, Pan Wang, Dawei Di, Shurong Dong, Jikui Luo, Guo Wang, Hongfeng Mu, Qian Zhao, Xuhan Guo, Qi Jie Wang, Tawfique Hasan, Zongyin Yang

{"title":"Stress-engineered ultra-broadband spectrometers","authors":"Gongyuan Zhang, Tom Albrow-Owen, Wenjun Peng, Xin Liang, Xianming Zhang, Pan Wang, Dawei Di, Shurong Dong, Jikui Luo, Guo Wang, Hongfeng Mu, Qian Zhao, Xuhan Guo, Qi Jie Wang, Tawfique Hasan, Zongyin Yang","doi":"10.1126/sciadv.adu4225","DOIUrl":"10.1126/sciadv.adu4225","url":null,"abstract":"<div >The evolution of miniaturized spectroscopic tools is pivotal for expanding the application of spectral data across scientific, industrial, and consumer domains. Recent advancements in computationally augmented systems have dramatically reduced device form factors toward those compatible with consumer tech integration. However, for a commercial reality, most applications demand operation across visible to short-wave infrared (SWIR) range. In this regard, existing miniaturized devices are either constrained by physical properties; use complex, costly, or unscalable fabrication techniques; or require multiple components to address separate parts of the spectrum. Here, we report on a low-cost, visible to SWIR, miniaturized spectrometer design enabled by a mass-producible, nonlithographic method of engineering planar dispersive elements from widely available plastics. By deforming shape memory epoxies, we encode spectral information, which is processed by a complementary metal oxide semiconductor sensor array and reconstructed via algorithms. This design offers broadband capability from 400 to 1600 nanometers and enables line-scanning spectral imaging, paving the way for affordable spectrometers.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu4225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving symmetric snap-through buckling via designed magnetic actuation 通过设计磁致动实现对称卡扣

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-05-14 DOI: 10.1126/sciadv.adw1259

Yingchao Zhang, Weicheng Huang, Mingchao Liu, Jing Yu, Huajian Gao

{"title":"Achieving symmetric snap-through buckling via designed magnetic actuation","authors":"Yingchao Zhang, Weicheng Huang, Mingchao Liu, Jing Yu, Huajian Gao","doi":"10.1126/sciadv.adw1259","DOIUrl":"10.1126/sciadv.adw1259","url":null,"abstract":"<div >Symmetric snap-through buckling, although both theoretically achievable and practically advantageous, has remained rare in bistable systems, with most studies favoring asymmetric snapping due to its lower energy barrier. Previous observations of symmetric snapping have been limited to high loading rates. In this work, we present a universal strategy to achieve symmetric snapping under quasi-static conditions by designing magnetization (M)–interface patterns that effectively suppress asymmetric modes. A simplified theoretical model demonstrates that this behavior results from the interplay between pitchfork and saddle-node bifurcations, with predictions validated through simulations and experiments using hard magnetic elastomers. Resisting forces generated by multiple M-interfaces counteract asymmetric snapping, enabling distinct symmetric configurations. Extending this approach to higher-order symmetric snapping, we uncover a quasi-linear scaling law between critical fields and snapping order. These findings establish a robust framework for designing snapping systems with enhanced control and predictability, as demonstrated by a mechanical-magnetic snapping switch, paving the way for advanced applications in precision engineering and magnetic-mechanical actuation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw1259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0