Science AdvancesPub Date : 2025-10-08DOI: 10.1126/sciadv.adq8390
Sarang Mahajan, Susobhan Das, Suhel Tamboli, Sanyukta Pandey, Anindya S. Bhattacharjee, Meenakshi Pardasani, Priyadharshini Srikanth, Shruti D. Marathe, Avi Adlakha, Lavanya Ranjan, Nixon M. Abraham
{"title":"Mouse olfactory system acts as anemo-detector and anemo-discriminator","authors":"Sarang Mahajan, Susobhan Das, Suhel Tamboli, Sanyukta Pandey, Anindya S. Bhattacharjee, Meenakshi Pardasani, Priyadharshini Srikanth, Shruti D. Marathe, Avi Adlakha, Lavanya Ranjan, Nixon M. Abraham","doi":"10.1126/sciadv.adq8390","DOIUrl":"10.1126/sciadv.adq8390","url":null,"abstract":"<div >Airflow detection while smelling is a fundamental requirement for olfaction, yet the mechanisms underlying such multimodal processing in the olfactory system remain unknown. We report here that mice can accurately discriminate airflow in the absence of whiskers. Modulated sniffing and refined calcium signaling in the olfactory bulb inhibitory network during olfactory anemo-discriminations confirmed the orthonasal airflow information processing. Genetic perturbation of AMPAR function and optogenetic control bidirectionally shifted the anemo-discrimination learning pace, with contrasting phenotypes observed for odor learning, engagement of inhibitory circuits, and setting the optimal inhibition level for stimulus refinement. Enhanced learning caused by multimodal odor-airflow stimuli at subthreshold levels confirmed the heightened olfactory perception by mechanical stimuli. Our results thus explain the multimodality of olfaction and reveal the unexplored dimensionality of odor perception.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq8390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-08DOI: 10.1126/sciadv.ady3689
Bin Cai, Jingwei Xu, Erik H. Collet, Ellen Aarts, Leo Luo, Alexander Leitner, Takashi Ishikawa, Pedro Beltrao, Chad G. Pearson, Martin Pilhofer, Michal Wieczorek
{"title":"Structure and assembly of the A-C linker connecting microtubule triplets in centrioles","authors":"Bin Cai, Jingwei Xu, Erik H. Collet, Ellen Aarts, Leo Luo, Alexander Leitner, Takashi Ishikawa, Pedro Beltrao, Chad G. Pearson, Martin Pilhofer, Michal Wieczorek","doi":"10.1126/sciadv.ady3689","DOIUrl":"10.1126/sciadv.ady3689","url":null,"abstract":"<div >Centriole assembly involves the coordination of centriolar modules. One module is the A-C linker, an enigmatic protein assembly connecting the A-microtubule of one microtubule triplet to the C-microtubule of the neighboring triplet. Here, we integrated biochemistry, multiscale cryo–electron microscopy, and AlphaFold modeling to investigate the architecture of the centriole. Using an improved centriole isolation method, we determined the structure of the A-C linker bound to microtubule triplets, which revealed how the A-C linker cross-links microtubules and integrates with the B-C junction. We found marked changes in the structure and composition of the A-C linker that correlate with the presence of other centriolar modules, including the pinhead, cartwheel, and inner scaffold. Our findings show that the A-C linker is a highly integrated component of the centriole whose polymorphism may orchestrate the assembly of spatially distinct centriolar modules, and provide a framework for dissecting the biology of centrioles.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady3689","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-08DOI: 10.1126/sciadv.adw4153
Elena Levi-D’Ancona, Emily M. Walker, Jie Zhu, Yamei Deng, Vaibhav Sidarala, Ava M. Stendahl, Emma C. Reck, Belle A. Henry-Kanarek, Anne C. Lietzke, Biaoxin Chai, Mabelle B. Pasmooij, Dre L. Hubers, Venkatesha Basrur, Sankar Ghosh, Linsey Stiles, Alexey I. Nesvizhskii, Orian S. Shirihai, Scott A. Soleimanpour
{"title":"TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy","authors":"Elena Levi-D’Ancona, Emily M. Walker, Jie Zhu, Yamei Deng, Vaibhav Sidarala, Ava M. Stendahl, Emma C. Reck, Belle A. Henry-Kanarek, Anne C. Lietzke, Biaoxin Chai, Mabelle B. Pasmooij, Dre L. Hubers, Venkatesha Basrur, Sankar Ghosh, Linsey Stiles, Alexey I. Nesvizhskii, Orian S. Shirihai, Scott A. Soleimanpour","doi":"10.1126/sciadv.adw4153","DOIUrl":"10.1126/sciadv.adw4153","url":null,"abstract":"<div >Innate immune signaling is activated in immunometabolic diseases, including type 2 diabetes, yet its impact on glucose homeostasis is controversial. Here, we report that the E3 ubiquitin ligase TRAF6 integrates innate immune signals following diet-induced obesity to promote glucose homeostasis through the induction of mitophagy. Whereas TRAF6 was dispensable for pancreatic β cell function at baseline, TRAF6 was pivotal for insulin secretion, mitochondrial respiration, and mitophagy following metabolic stress in mouse and human islets. TRAF6 was critical for the recruitment and function of the ubiquitin-mediated (Parkin-dependent) mitophagy machinery. Glucose intolerance induced by TRAF6 deficiency following metabolic stress was reversed by concomitant Parkin deficiency by relieving obstructions in receptor-mediated (Parkin-independent) mitophagy. Our results establish that TRAF6 is vital for traffic through Parkin-mediated mitophagy and implicates TRAF6 in the cross-regulation of ubiquitin- and receptor-mediated mitophagy. Together, we illustrate that β cells engage innate immune signaling to adaptively respond to a diabetogenic environment.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw4153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-08DOI: 10.1126/sciadv.adz8940
Shuo Zhang, Haocheng Yong, Jinhao Zhang, Zhiping Chai, Xingxing Ke, Zisheng Zong, Han Ding, Zhuang Zhang, Kan Li, Zhigang Wu
{"title":"Mechanically strengthened silicone-based origami structures via hierarchical interfacial shrink fitting","authors":"Shuo Zhang, Haocheng Yong, Jinhao Zhang, Zhiping Chai, Xingxing Ke, Zisheng Zong, Han Ding, Zhuang Zhang, Kan Li, Zhigang Wu","doi":"10.1126/sciadv.adz8940","DOIUrl":"10.1126/sciadv.adz8940","url":null,"abstract":"<div >Soft structured materials—e.g., silicone-based elastomer, capable of programmable morphologies and mechanical strength—are promising for high-performance structure construction in metamaterials and soft robots. However, once prototyped, polydimethylsiloxane (PDMS)–based silicone elastomer is limited in mechanical strength and programmable spatial construction due to the flexible polymer matrix and mismatched interface with other materials. We propose a mechanically strengthened PDMS-based origami structure (MSOS) via polymethyl methacrylate (PMMA)/acetone solution swelling. The planar elastomer precursor can be swollen-folded into programmable spatial construction based on mechanically strengthened creases during solvent diffusion and de-gelatinization. This strengthened crease is induced by a hierarchical shrink-fitting based on solute molecular chain insertion and a seamless coupling interface between elastomer microstructures and solidified PMMA. We present a programmable MSOS to support a load more than 58,100 times of its own weight and a pillbug-inspired ringbot to resist heavy impact. Our work provides a strategy toward customized mechanically strengthened soft material for developing functional structural architectures and soft origami robots.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz8940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atmospheric water cluster–catalyzed formation of nitroaromatics as a secondary aerosol source","authors":"Haiping Xiong, Xiaoyu Liu, Chongwen Sun, Xiangyu Zhang, Xinming Wang, Jingxin Lin, Likun Xue, Xiaomin Sun, Xiaona Shang, Fangfang Ma, Hongbin Xie, Jingwen Chen, Gang Yan, Jiangbin Shu, Hongbo Fu, Lin Wang, Yinon Rudich, Christian George, Abdelwahid Mellouki, Defeng Zhao, Xinke Wang, Hartmut Herrmann, Jianmin Chen","doi":"10.1126/sciadv.adv7805","DOIUrl":"10.1126/sciadv.adv7805","url":null,"abstract":"<div >Nitroaromatic compounds (NACs) are an abundant class of compounds in atmospheric particulate matter, exerting considerable impacts on air quality, climate, and public health. They are typically derived from secondary formation, which is generated through atmospheric chemical reactions involving precursor compounds, such as phenolic compounds. However, information on NAC formation mechanisms remains limited. Here, we found that particulate-phase NAC concentrations were notably affected by relative humidity (RH) in field observations. Smog chamber experiments indicated that RH could influence NAC formation via changes in gaseous water concentration, rather than solely through aerosol liquid water content. Theoretical calculations further clarified that water clusters (WCs), formed from gaseous water, can notably lower reaction energy barriers along the NAC formation pathway, rendering this pathway competitive under atmospheric conditions. Hence, we propose a potential mechanism in which WCs catalyze NAC formation, offering a previously unidentified perspective on atmospheric secondary aerosol formation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv7805","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comprehensive analog signal processing platform enabled by acoustic charge transport in two-dimensional materials","authors":"Yueyi Sun, Siming Liu, Jiefei Zhu, Dexing Liu, Jiwei Chen, Yingjie Luo, Yihong Sun, Min Zhang, Mansun Chan, Cary Y. Yang, Changjian Zhou","doi":"10.1126/sciadv.ady7476","DOIUrl":"10.1126/sciadv.ady7476","url":null,"abstract":"<div >Miniaturized, low-loss analog signal processing is crucial for next-generation wireless communication and sensing. Although two-dimensional acoustic charge transport (2D-ACT) devices integrating 2D field-effect transistors (FETs) with surface acoustic waves (SAWs) have substantial potential, previous work has been confined to dc operation, limiting real-time applications. Here, we present a hybrid platform that enables comprehensive dc and ac analog signal processing within a 2D-ACT device. By synergistically integrating 2D-FET and SAW components, our system achieves real-time subwavelength carrier monitoring and ac signal manipulation. ac measurements further elucidate mechanisms of dc acoustoelectric current generation. Notably, by controlling the phase and intensity of counter-propagating SAWs, we demonstrate analog signal addition and subtraction capabilities not previously realized in 2D-ACT devices. This platform establishes a benchmark for compact, low-loss ACT devices in ac signal processing, representing a notable advance for acoustoelectric technologies and 2D material systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady7476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-08DOI: 10.1126/sciadv.adx2628
Shaomei Lin, Zhe Cui, Hao Li, Kun Wang, Kerui Li, Qinghong Zhang, Yaogang Li, Chengran Du, Chengyi Hou, Hongzhi Wang
{"title":"Plasma-enhanced electronic textiles for energy harvesting","authors":"Shaomei Lin, Zhe Cui, Hao Li, Kun Wang, Kerui Li, Qinghong Zhang, Yaogang Li, Chengran Du, Chengyi Hou, Hongzhi Wang","doi":"10.1126/sciadv.adx2628","DOIUrl":"10.1126/sciadv.adx2628","url":null,"abstract":"<div >Electrostatic energy harvesting and storage technologies for next-generation wearable devices are typically constrained by slow carrier dynamics and dielectric polarization delays. Here, we developed a plasma-enabled energy textile (PEET) by emulating the carrier transport mechanism in lightning return strokes. By engineering plasma-treated discharge microchannels, our design enables direct conduction current generation through cascading ionization, overcoming the efficiency limitations of conventional polarization-dependent systems. Under 2-hertz mechanical excitation, the PEET achieves a current density of 2.5 amperes per square centimeter, an average power output of 4.46 watts per square meter per hertz, and an energy conversion efficiency of 19%—two orders of magnitude higher than conventional electrostatic energy harvesting technologies, e.g., triboelectric, piezoelectric, and capacitive systems. This work represents a transformative advance in electrostatic energy harvesting, enabling efficient and scalable wearable energy solutions.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx2628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-08DOI: 10.1126/sciadv.ady1386
Rui Zhang, Yanlong Li, Yawei Li, Huanhuan Ma, Chunyang Zuo, Jing Yang, Yizan Ma, Jie Kong, Xun Wei, Longfu Zhu, Alice Y. Cheung, Xianlong Zhang, Ling Min
{"title":"Polyploidization-driven formation of the GhRALF30L gene cluster confers basal thermotolerance in cotton male reproductive organs via GhFERA1/GhCAPA1","authors":"Rui Zhang, Yanlong Li, Yawei Li, Huanhuan Ma, Chunyang Zuo, Jing Yang, Yizan Ma, Jie Kong, Xun Wei, Longfu Zhu, Alice Y. Cheung, Xianlong Zhang, Ling Min","doi":"10.1126/sciadv.ady1386","DOIUrl":"10.1126/sciadv.ady1386","url":null,"abstract":"<div >High-temperature stress in plant stamens frequently causes male sterility, limiting crop yields. Gene duplication resulting from polyploidization offers insights into plant adaptation to environmental stress. Here, we reveal that extensive duplication of <i>GhRALF30L</i>, which encodes an intrinsically disordered small peptide, contributes to thermotolerance in cotton male reproductive organs. Polyploidization has driven the formation of 23 <i>GhRALF30L</i> genes in allotetraploid cotton, whereas only four or five homologs are identified in its two diploid ancestors. Expression and functional analyses confirm that <i>GhRALF30L</i> regulates thermotolerance in a dosage-dependent manner, with reduced dosage decreasing heat resistance. Under heat stress, GhRALF30L interacts with GhFERA1/GhCAPA1 and enhances their condensation at the plasma membrane, which activates heat stress responses by up-regulating the expression of heat shock factors (<i>HSFs</i>), heat shock proteins (<i>HSPs</i>), and reactive oxygen species scavenging genes. Our findings demonstrate that the <i>GhRALF30L</i> gene cluster, resulting from polyploidization, confers thermotolerance through facilitating the condensation of GhFERA1/GhCAPA1.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady1386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Replacing cholesterol and PEGylated lipids with zwitterionic ionizable lipids in LNPs for spleen-specific mRNA translation","authors":"Yu Zhao, Zhen Tian, Jialiang Wang, Meng Cui, Zeyu Cao, Pingchuan Liu, Ruoxin Li, Simian Cai, Yuping Hu, Yufei Ma, Erica Wagner, Amy Laflin, Wenchao Gu, Yanru Cui, Chenjue Tang, Herbert Fountain, Ruixuan Wang, Shaoyi Jiang","doi":"10.1126/sciadv.ady6460","DOIUrl":"10.1126/sciadv.ady6460","url":null,"abstract":"<div >The spleen is emerging as a key vaccination target. However, existing lipid nanoparticles (LNPs) primarily accumulate in the liver, limiting their efficacy in vaccine therapy. The cholesterol in current LNP formulations promotes their uptake by hepatocytes, while the polyethylene glycol-modified (PEGylated) lipids induce PEG immunogenicity, further reducing the efficacy in the setting of repeated administrations. We develop a three-component (ThrCo) LNP by replacing cholesterol and PEGylated lipids in Pfizer-BioNTech LNPs with zwitterionic pyridine carboxybetaine (PyCB) ionizable lipids (ILs), achieving ~70% lower liver accumulation and a 4.5-fold increase in spleen-specific mRNA translation. PyCB ILs enhance LNP hydrophilicity, stabilizing the outer membrane to compensate for cholesterol removal. PyCB groups also exhibit strong protonation at endosomal pH, facilitating mRNA translation. The zwitterionic surface of ThrCo LNP reduces protein adsorption, thereby preventing the accelerated blood clearance effect caused by PEGylated lipids following repeated administrations. Thus, ThrCo LNP–based vaccines efficiently deliver mRNA to splenic antigen-presenting cells, boosting immune responses and improving therapeutic outcomes.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady6460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-08DOI: 10.1126/sciadv.ady1944
Zichen Zhang, Yu Gong, Xin-Yu Su, Yujiao Deng, Rui Du, Chun-Li Li, Yan Wang, Xing-Lei Song, Qin Jiang, Ying Li, Yujin Jian, Xiaoping Tong, Guang-Hai Wang, Jun Chen, Tian-Le Xu, Ming-Gang Liu, Fan Jiang
{"title":"Dysfunction of the paraventricular thalamus–prelimbic cortex circuit underlies maternal separation–induced deficits in contagious pain","authors":"Zichen Zhang, Yu Gong, Xin-Yu Su, Yujiao Deng, Rui Du, Chun-Li Li, Yan Wang, Xing-Lei Song, Qin Jiang, Ying Li, Yujin Jian, Xiaoping Tong, Guang-Hai Wang, Jun Chen, Tian-Le Xu, Ming-Gang Liu, Fan Jiang","doi":"10.1126/sciadv.ady1944","DOIUrl":"10.1126/sciadv.ady1944","url":null,"abstract":"<div >Contagious pain is considered one of the most common forms of emotional contagion observed in animal models. Nevertheless, little is known about the precise neural mechanisms governing the regulation of contagious pain in response to diverse environmental stressors. Here, we report that early life maternal separation (MS) precipitates impairments in the pain contagion between familiar partners. Specifically, we identify the indispensable role of glutamatergic projections from the paraventricular thalamus (PVT) to the prelimbic cortex (PrL) for the development of vicarious pain hypersensitivity. MS dampens activation of the PVT → PrL pathway during social interactions between observer and painful demonstrator. Augmenting the excitability or activity of the PVT → PrL circuit through chemogenetic interventions or tactile stimulation resembling social touch significantly ameliorates the MS-evoked contagious pain deficits. Collectively, our findings delineate a neural circuitry substrate underlying the loss of contagious pain stemming from MS and propose a potential therapeutic avenue for mitigating empathic impairments associated with early life adversity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady1944","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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