In-body current path manipulation with minimal attenuation

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-07-23 DOI:10.1126/sciadv.adx5922

Donghyeon Kang, Byung-Joon Park, Joon-Ha Hwang, Young-Jun Kim, So-Hee Kim, Hyun Woo Kim, Ki Jun Yu, Jinyoung Jeon, Hyeon Yeong Lee, Youngwook Chung, Soo Hyun Nam, Byung-Ok Choi, Sang-Woo Kim

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Abstract

Wireless power transfer–based neuromodulation has emerged as a promising alternative to battery-powered implants. However, its practical application is hindered by limited therapeutic efficacy resulting from low power transfer efficiency, shallow penetration depth, and safety concerns. In this study, we report an in-body current path manipulation and concentration for advanced targeted neuromodulation, overcoming the limitations of conventional technologies. By implanting a focusing electrode, we were able to direct the triboelectric current, which has a low frequency and high impedance generated by human movement, toward the target area, with the concentrated current exhibiting minimal attenuation regardless of the electrode size, implantation site, and depth. Applying our technology to modulate damaged neural systems confirmed therapeutic efficacy and validated safety, demonstrating its potential for next-generation targeted neuromodulation.

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最小衰减的体内电流路径操纵

基于无线能量传输的神经调节已经成为电池供电植入物的一种很有前途的替代方案。然而，由于功率传输效率低、穿透深度浅以及安全问题，其治疗效果有限，阻碍了其实际应用。在这项研究中，我们报道了一种体内电流路径操纵和集中用于高级靶向神经调节，克服了传统技术的局限性。通过植入聚焦电极，我们能够将由人体运动产生的低频高阻抗摩擦电流定向到目标区域，无论电极尺寸、植入位置和深度如何，集中电流都表现出最小的衰减。应用我们的技术来调节受损的神经系统，证实了治疗效果和安全性，展示了下一代靶向神经调节的潜力。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.