Science Advances最新文献_第4页

Superconductivity in compressed quasi−one-dimensional face-sharing hexagonal perovskite chalcogenides 压缩准一维共面六方钙钛矿硫系化合物的超导性

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-12 DOI: 10.1126/sciadv.adv1894

Feng Ke, Shanyuan Niu, Jiajia Feng, Ketao Yin, Minkyung Han, Hong Yang, Bai Yang Wang, Anna Celeste, Chunjing Jia, Bin Chen, Lin Wang, Harold Y. Hwang, Yongjun Tian, Wendy L. Mao, Yu Lin

{"title":"Superconductivity in compressed quasi−one-dimensional face-sharing hexagonal perovskite chalcogenides","authors":"Feng Ke, Shanyuan Niu, Jiajia Feng, Ketao Yin, Minkyung Han, Hong Yang, Bai Yang Wang, Anna Celeste, Chunjing Jia, Bin Chen, Lin Wang, Harold Y. Hwang, Yongjun Tian, Wendy L. Mao, Yu Lin","doi":"10.1126/sciadv.adv1894","DOIUrl":"10.1126/sciadv.adv1894","url":null,"abstract":"<div >Oxide perovskite superconductors typically feature stacks of metal-oxygen octahedra or planar blocks connected through corners, forming three-dimensional (3D) or 2D layered structures. Here, we find a group of quasi-1D superconducting materials among hexagonal perovskite chalcogenides with face-sharing connectivity. Resistance and magnetization measurements demonstrate anisotropic superconductivity in compressed barium titanium trisulfide (BaTiS<sub>3</sub>) at a low hole carrier concentration of (1.6 ± 0.1) × 10<sup>21</sup> per cubic centimeter, with the highest superconducting temperature (<i>T</i><sub>c</sub>) reaching ~9.3 kelvin. Synchrotron x-ray diffraction indicates that the superconducting phase retains a hexagonal perovskite structure consisting of quasi-1D infinite titanium hexasulfide chains. Density functional theory calculations, combined with the observed decrease in the maximum <i>T</i><sub>c</sub> from ~9.3 to ~6.2 kelvin upon substituting sulfur with selenium, suggest that electron-phonon interactions play a key role in the pairing mechanism of superconducting BaTiX<sub>3</sub> (X = sulfur and selenium). Our study offers a quasi-1D platform with face-sharing metal-chalcogen octahedra for understanding the mechanism of emerging electronic states in perovskite materials.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv1894","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLL to Richter syndrome: Integrating network strategies with experiments elucidating disease drivers and personalized therapies 里希特综合征的CLL：整合网络策略与阐明疾病驱动因素和个性化治疗的实验。

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-12 DOI: 10.1126/sciadv.adu7705

Julia Maier, Julian D. Schwab, Silke D. Werle, Ralf Marienfeld, Stephan Stilgenbauer, Peter Möller, Nensi Ikonomi, Hans A. Kestler

{"title":"CLL to Richter syndrome: Integrating network strategies with experiments elucidating disease drivers and personalized therapies","authors":"Julia Maier, Julian D. Schwab, Silke D. Werle, Ralf Marienfeld, Stephan Stilgenbauer, Peter Möller, Nensi Ikonomi, Hans A. Kestler","doi":"10.1126/sciadv.adu7705","DOIUrl":"10.1126/sciadv.adu7705","url":null,"abstract":"<div >Chronic lymphocytic leukemia (CLL) is a common neoplasm that carries the risk of transformation into Richter’s syndrome (RS), a highly aggressive B cell lymphoma with poor prognosis. Limited availability of animal models and cell lines hinders understanding of transformation mechanisms. Addressing this gap, we established the first in silico dynamic model of the disease. Our methodology integrates mathematical logic modeling with experimental data to identify disease drivers, mechanisms, and potential therapeutic targets. We validated the model by comparing the model’s readout with experimental data from different biological levels, such as single-cell RNA sequencing analyses and a CLL/RS patient formalin-fixed paraffin-embedded (FFPE) tissue cohort. Our analyses identified BMI1 proto-oncogene and TP53 loss as key RS progression regulators. In addition, we performed an in silico target screening to identify promising target combinations in a personalized fashion. Through the synergy of mathematical modeling with experimental readouts, our model provides a complementary approach to investigate the process of CLL transformation to RS.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu7705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living with temperature changes: Salicylic acid at the crossroads of plant immunity and temperature resilience 适应温度变化：水杨酸在植物免疫和温度恢复能力的十字路口

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-10 DOI: 10.1126/sciadv.ady3327

Wei Li, Guoqing Sun, Wentao Yang, Naiyi Lin, Kaihuai Li, Fengquan Liu, Ming Chang (常明)

引用次数: 0

CD8+HLA-DR+CD27+ T cells define a population of naturally occurring regulatory precursors in humans CD8+HLA-DR+CD27+ T细胞定义了人类自然发生的调节前体群体

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-10 DOI: 10.1126/sciadv.adw1702

Huidong Guo, Bixia Wang, Zhigui Wu, Qi Zhang, Xinya Jiang, Fangqing Zhang, Jingrui Zhou, Shuang Fan, Yang Zhou, Zheng-Li Xu, Yu Wang, Xiang-Yu Zhao, Xiao-Jun Huang

{"title":"CD8+HLA-DR+CD27+ T cells define a population of naturally occurring regulatory precursors in humans","authors":"Huidong Guo, Bixia Wang, Zhigui Wu, Qi Zhang, Xinya Jiang, Fangqing Zhang, Jingrui Zhou, Shuang Fan, Yang Zhou, Zheng-Li Xu, Yu Wang, Xiang-Yu Zhao, Xiao-Jun Huang","doi":"10.1126/sciadv.adw1702","DOIUrl":"10.1126/sciadv.adw1702","url":null,"abstract":"<div >Regulatory T<sub>reg</sub> cells are essential for immune homeostasis. While CD4 T<sub>reg</sub> cells are well characterized, CD8 T<sub>reg</sub> cells remain less understood and are primarily observed in pathological or experimental contexts. Here, we identify a naturally occurring CD8 regulatory precursor T<sub>rp</sub> cell at the steady state, defined by a CD8<sup>+</sup>HLA-DR<sup>+</sup>CD27<sup>+</sup> phenotype and a transcriptome resembling CD4 T<sub>reg</sub> cells. Multiomics analyses reveal activation of <i>TCF7</i> and costimulatory and co-inhibitory molecules in CD8 T<sub>rp</sub> cells. CD8 T<sub>rp</sub> cells suppress T cell expansion in vitro and in vivo. In a humanized xenogeneic graft-versus-host disease (GVHD) model, they dampen T cell activation, alleviate GVHD pathology, and prolong survival without impairing antileukemia activity. Mechanistically, CD8 T<sub>rp</sub> cells promote immune regulation by inducing FOXP3 expression in both CD4 T<sub>reg</sub> cells and themselves. Their expansion also correlates with immune homeostasis restoration post–allogeneic stem cell transplantation. These findings establish CD8 T<sub>rp</sub> cells as a naturally occurring regulatory precursor population that promotes transplantation tolerance.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw1702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational assembly of 3D network materials and electronics through tensile buckling 通过拉伸屈曲合理组装三维网络材料和电子元件

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-10 DOI: 10.1126/sciadv.adz0718

Xiaonan Hu, Zhi Liu, Zhenjia Tang, Shiwei Xu, Zhangming Shen, Yue Xiao, Youzhou Yang, Renheng Bo, Shuheng Wang, Wenbo Pang, Yihui Zhang

{"title":"Rational assembly of 3D network materials and electronics through tensile buckling","authors":"Xiaonan Hu, Zhi Liu, Zhenjia Tang, Shiwei Xu, Zhangming Shen, Yue Xiao, Youzhou Yang, Renheng Bo, Shuheng Wang, Wenbo Pang, Yihui Zhang","doi":"10.1126/sciadv.adz0718","DOIUrl":"10.1126/sciadv.adz0718","url":null,"abstract":"<div >Bioinspired network designs are widely exploited in biointegrated electronics and tissue engineering because of their high stretchability, imperfection insensitivity, high permeability, and biomimetic J-shaped stress-strain responses. However, the fabrication of three-dimensionally (3D) architected electronic devices with ordered constructions of network microstructures remains challenging. Here, we introduce the tensile buckling of stacked multilayer precursors as a unique route to 3D network materials with regularly distributed 3D microstructures. A data-driven topology optimization framework enables efficient search of the optimal 2D precursor pattern that maximizes out-of-plane dimension of the resulting 3D network material. Computational and experimental results demonstrate rational assembly of optimal multilayer precursor structures into well-architected 3D network materials with an evident interlayer separation. The resulting 3D network materials offer anisotropic, tunable J-shaped stress-strain curves, which can be tailored to reproduce stress-strain responses of biological tissues. Demonstration of reconfigurable volumetric 3D display suggests rich application opportunities in biointegrated electronics and tissue scaffolds.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz0718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of PTDSS1 in tumor cells improves immunogenicity and response to anti–PD-1 therapy 肿瘤细胞中PTDSS1的缺失改善了免疫原性和对抗pd -1治疗的反应

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-10 DOI: 10.1126/sciadv.adx8134

Jielin Liu, Shelley Herbrich, Sreyashi Basu, Yulong Chen, Ashwat Nagarajan, Swetha Anandhan, Sangeeta Goswami, Liangwen Xiong, Baoxiang Guan, Padmanee Sharma

{"title":"Loss of PTDSS1 in tumor cells improves immunogenicity and response to anti–PD-1 therapy","authors":"Jielin Liu, Shelley Herbrich, Sreyashi Basu, Yulong Chen, Ashwat Nagarajan, Swetha Anandhan, Sangeeta Goswami, Liangwen Xiong, Baoxiang Guan, Padmanee Sharma","doi":"10.1126/sciadv.adx8134","DOIUrl":"10.1126/sciadv.adx8134","url":null,"abstract":"<div ><i>PTDSS1</i> (phosphatidylserine synthase 1) encodes an enzyme that facilitates production of phosphatidylserine (PS), which mediates a global immunosuppressive signal. Here, based on in vivo CRISPR screen, we identified PTDSS1 as a target to improve anti–PD-1 therapy. Depletion of <i>Ptdss1</i> in tumor cells increased expression of interferon-γ (IFN-γ)–regulated genes, including <i>B2m</i>, <i>Cxcl9</i>, <i>Cxcl10</i>, and <i>Stat1</i>, even in the absence of IFN-γ stimulation in vitro. Loss of <i>Ptdss1</i> in tumor cells also led to increased expression of MHC-I, enhanced cytotoxicity of CD8<sup>+</sup> T cells, and increased frequency of an iNOS<sup>+</sup> myeloid subset. A gene signature derived from the iNOS<sup>+</sup> myeloid cell subset correlated with clinical benefit in patients treated with anti–PD-1 therapy. Moreover, genetic and pharmacological inhibition of <i>Ptdss1</i> in different tumor models improved anti–PD-1 therapy. Together, our results provide insights on a therapeutic strategy for overcoming immunosuppression by inhibiting PTDSS1 and provide rationale for development of a combination immunotherapy strategy composed of PTDSS1 inhibition plus PD-1 blockade.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx8134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Locusts adopt IP3 as a second messenger for olfactory signal transduction 蝗虫采用IP3作为嗅觉信号转导的第二信使

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-10 DOI: 10.1126/sciadv.ads1352

Jing Yang, Helen He, Shijie Dong, Jing Lv, Lili Cheng, Qiaoqiao Yu, Le Kang, Xiaojiao Guo

{"title":"Locusts adopt IP3 as a second messenger for olfactory signal transduction","authors":"Jing Yang, Helen He, Shijie Dong, Jing Lv, Lili Cheng, Qiaoqiao Yu, Le Kang, Xiaojiao Guo","doi":"10.1126/sciadv.ads1352","DOIUrl":"10.1126/sciadv.ads1352","url":null,"abstract":"<div >Insects, unlike vertebrates, use heteromeric complexes of odorant receptors and co-receptors for olfactory signal transduction. However, the secondary messengers involved in this process are largely unknown. Here, we use the olfactory signal transduction of the aggregation pheromone 4-vinylanisole (4VA) as a model to address this question. When locusts detect 4VA, the pheromone is transported by OBP10 and OBP13 to the OR35–Orco receptor complex, thereby activating downstream pathways in the antenna. A pivotal downstream molecule, the lipid-binding protein Clvs2, facilitates phosphatidylinositol 4,5-bisphosphate transportation across the cytolemma, providing more substrates for inositol trisphosphate (IP<sub>3</sub>) production. PLCe1, a biosynthetic enzyme, boosts IP<sub>3</sub> levels in the antennal lobe of the brain. IP<sub>3</sub> is responsible for converting chemical signals from the antenna into neural signals, confirming IP<sub>3</sub> as a secondary messenger in olfaction perception instead of GPCR in locusts. These findings elucidate the universal function of IP<sub>3</sub> in olfactory signal perception, shedding light on the key nodes of insect olfactory signal transduction.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads1352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

North Pacific meridional mode has larger impacts on El Niño evolution than the March Madden-Julian Oscillation 北太平洋经向模态对El Niño演化的影响大于3月麦登-朱利安涛动

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-10 DOI: 10.1126/sciadv.adv8621

Yu Liang, Shang-Ping Xie, Alexey Fedorov, Stephen G. Yeager

{"title":"North Pacific meridional mode has larger impacts on El Niño evolution than the March Madden-Julian Oscillation","authors":"Yu Liang, Shang-Ping Xie, Alexey Fedorov, Stephen G. Yeager","doi":"10.1126/sciadv.adv8621","DOIUrl":"10.1126/sciadv.adv8621","url":null,"abstract":"<div >The El Niño–Southern Oscillation (ENSO) is a key driver of global climate variability. Early-season westerly wind bursts (WWBs) have long been suggested to be important for ENSO evolution and diversity, with the Madden-Julian Oscillation (MJO) among the main sources of WWBs. However, MJO’s contribution to ENSO evolution has been difficult to quantify. Here, using an ensemble hindcast approach specifically designed to isolate internal atmospheric variability, we evaluate the influences of March MJO on subsequent ENSO development. Our results show that the March MJO, under favorable background conditions, by itself has limited impacts on ENSO due to weak equatorial air-sea coupling in spring. In comparison, the North Pacific Oscillation–induced meridional mode exerts a more sustained influence on ENSO evolution. A cyclonic circulation anomaly over Hawaii, associated with the Pacific-North American pattern, also plays a role. These findings suggest that March MJO activity alone may not be a reliable predictor for ENSO evolution, but underscore the importance of North Pacific atmospheric variability.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv8621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression 单细胞多组和空间分析揭示了1型糖尿病进展的胰腺细胞类型特异性基因调控程序

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-10 DOI: 10.1126/sciadv.ady0080

Rebecca Melton, Sara Jimenez, Weston Elison, Luca Tucciarone, Abigail Howell, Gaowei Wang, Denise Berti, Elisha Beebe, Michael Miller, Chun Zeng, Carolyn McGrail, Kennedy VanderStel, Katha Korgaonkar, Ruth Elgamal, Hannah Mummey, Joshua Chiou, Emily Griffin, Irina Kusmartseva, Mark Atkinson, Sebastian Preissl, Fabian J. Theis, Maike Sander, Kyle J. Gaulton

{"title":"Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression","authors":"Rebecca Melton, Sara Jimenez, Weston Elison, Luca Tucciarone, Abigail Howell, Gaowei Wang, Denise Berti, Elisha Beebe, Michael Miller, Chun Zeng, Carolyn McGrail, Kennedy VanderStel, Katha Korgaonkar, Ruth Elgamal, Hannah Mummey, Joshua Chiou, Emily Griffin, Irina Kusmartseva, Mark Atkinson, Sebastian Preissl, Fabian J. Theis, Maike Sander, Kyle J. Gaulton","doi":"10.1126/sciadv.ady0080","DOIUrl":"10.1126/sciadv.ady0080","url":null,"abstract":"<div >Cell type–specific regulatory programs that drive type 1 diabetes (T1D) in the pancreas are poorly understood. Here, we performed single-nucleus multiomics and spatial transcriptomics in up to 32 nondiabetic (ND), autoantibody-positive (AAB<sup>+</sup>), and T1D pancreas donors. Genomic profiles from 853,005 cells mapped to 12 pancreatic cell types, including multiple exocrine subtypes. β, Acinar, and other cell types, and related cellular niches, had altered abundance and gene activity in T1D progression, including distinct pathways altered in AAB<sup>+</sup> compared to T1D. We identified epigenomic drivers of gene activity in T1D and AAB<sup>+</sup> which, combined with genetic association, revealed causal pathways of T1D risk including antigen presentation in β cells. Last, single-cell and spatial profiles together revealed widespread changes in cell-cell signaling in T1D including signals affecting β cell regulation. Overall, these results revealed drivers of T1D in the pancreas, which form the basis for therapeutic targets for disease prevention.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady0080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermodal microwave-to-optical transduction using silicon-on-sapphire optomechanical ring resonator 利用蓝宝石上硅光机械环形谐振器的多模态微波光转导

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-09-10 DOI: 10.1126/sciadv.adx6485

I-Tung Chen, Nicholas S. Yama, Haoqin Deng, Qixuan Lin, Yue Yu, Abhi Saxena, Arka Majumdar, Kai-Mei C. Fu, Mo Li

{"title":"Intermodal microwave-to-optical transduction using silicon-on-sapphire optomechanical ring resonator","authors":"I-Tung Chen, Nicholas S. Yama, Haoqin Deng, Qixuan Lin, Yue Yu, Abhi Saxena, Arka Majumdar, Kai-Mei C. Fu, Mo Li","doi":"10.1126/sciadv.adx6485","DOIUrl":"10.1126/sciadv.adx6485","url":null,"abstract":"<div >Optomechanical and electro-optomechanical systems have emerged as one of the most promising approaches for quantum microwave-to-optical transduction to interconnect distributed quantum modalities for scaling the quantum systems. These systems use suspended structures to increase mode overlap and mitigate loss to achieve high efficiency. However, the suspended design’s poor heat dissipation under strong drive limits the ultimate efficiency. Here, we demonstrate an unsuspended optomechanical ring resonator (OMR) based on the silicon-on-sapphire (SOS) platform for microwave-to-optical frequency conversion. The OMR achieves a triply resonant optical-to-optical conversion with an enhanced coupling rate <i>G<sub>b</sub></i> = 3.6 gigahertz per square-root milliwatt at a peak conversion efficiency of 1.2% with 3.6-milliwatt microwave drive power and a microwave-to-optical conversion efficiency of 1.5 × 10<sup>−5</sup> at 10-milliwatt optical drive power. Our results show that the unsuspended SOS platform, which mitigates the thermal effect and is compatible with superconducting qubits, is a promising platform for optomechanical circuitry and quantum transduction.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 37","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx6485","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0