Science Advances最新文献_第4页

Interfacial charge transfer and its impact on transport properties of LaNiO 3 /LaFeO 3 superlattices 界面电荷转移及其对 LaNiO 3 /LaFeO 3 超晶格传输特性的影响

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adq6687

Le Wang, Zhifei Yang, Krishna Prasad Koirala, Mark E. Bowden, John W. Freeland, Peter V. Sushko, Cheng-Tai Kuo, Scott A. Chambers, Chongmin Wang, Bharat Jalan, Yingge Du

{"title":"Interfacial charge transfer and its impact on transport properties of LaNiO 3 /LaFeO 3 superlattices","authors":"Le Wang, Zhifei Yang, Krishna Prasad Koirala, Mark E. Bowden, John W. Freeland, Peter V. Sushko, Cheng-Tai Kuo, Scott A. Chambers, Chongmin Wang, Bharat Jalan, Yingge Du","doi":"10.1126/sciadv.adq6687","DOIUrl":"https://doi.org/10.1126/sciadv.adq6687","url":null,"abstract":"Charge transfer or redistribution at oxide heterointerfaces is a critical phenomenon, often leading to remarkable properties such as two-dimensional electron gas and interfacial ferromagnetism. Despite studies on LaNiO 3 /LaFeO 3 superlattices and heterostructures, the direction and magnitude of the charge transfer remain debated, with some suggesting no charge transfer due to the high stability of Fe 3+ (3d 5 ). Here, we synthesized a series of epitaxial LaNiO 3 /LaFeO 3 superlattices and demonstrated partial (up to ~0.5 e − /interface unit cell) charge transfer from Fe to Ni near the interface, supported by density functional theory simulations and spectroscopic evidence of changes in Ni and Fe oxidation states. The electron transfer from LaFeO 3 to LaNiO 3 and the subsequent rearrangement of the Fe 3d band create an unexpected metallic ground state within the LaFeO 3 layer, strongly influencing the in-plane transport properties across the superlattice. Moreover, we establish a direct correlation between interfacial charge transfer and in-plane electrical transport properties, providing insights for designing functional oxide heterostructures with emerging properties.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"38 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-line tempering eliminates the domain boundary in perovskite single crystals for high–energy resolution ionizing radiation detectors 在线回火消除了用于高能量分辨率电离辐射探测器的过氧化物单晶中的畴边界

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adq6866

Xueying Yang, Yilong Song, Lixiang Wang, Yuan Sun, Bowen Jin, Jing Wang, Hui Liu, Yujie Yang, Qianqian Lin, Yanjun Fang, Qingfeng Dong

{"title":"In-line tempering eliminates the domain boundary in perovskite single crystals for high–energy resolution ionizing radiation detectors","authors":"Xueying Yang, Yilong Song, Lixiang Wang, Yuan Sun, Bowen Jin, Jing Wang, Hui Liu, Yujie Yang, Qianqian Lin, Yanjun Fang, Qingfeng Dong","doi":"10.1126/sciadv.adq6866","DOIUrl":"https://doi.org/10.1126/sciadv.adq6866","url":null,"abstract":"Metal halide perovskite single crystals (SCs) emerge as a promising candidate for ionizing radiation detection. The realization of top-performing radiation detectors typically relies on careful crystal selection from broad candidate groups, as residual strain remains unavoidable during the SC growth process, which often leads to the formation of ferroelastic domains with varied orientations. Here, we introduce an in-line tempering strategy to alleviate microstrain and homogenize the domain orientation across methylammonium lead iodide (MAPbI 3 ) perovskite SCs. The progressive strain relief during the phase transition in situ, demonstrated by the removal of ferroelastic domain walls, substantially enhances the crystallinity and the optoelectronic properties of the MAPbI 3 SCs. As a result, the gamma-ray energy spectrum detector leveraging these strain-relaxed SCs achieves an energy resolution of 7.2% at 59.5 keV for a 241 Am gamma-ray source, and the 25-pixel device performs highly uniformly with concentrated current distribution, which paves the way for its implementation in high-resolution radiation spectroscopy.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"51 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-12-13 Epub Date: 2024-12-11 DOI: 10.1126/sciadv.adr4399

Na Chen, Jing Xi, Na Du, Ruichen Shen, Rui Zhao, Wei He, Tianhuang Peng, Yanbing Yang, Yun Zhang, Lilei Yu, Weihong Tan, Quan Yuan

{"title":"Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction.","authors":"Na Chen, Jing Xi, Na Du, Ruichen Shen, Rui Zhao, Wei He, Tianhuang Peng, Yanbing Yang, Yun Zhang, Lilei Yu, Weihong Tan, Quan Yuan","doi":"10.1126/sciadv.adr4399","DOIUrl":"10.1126/sciadv.adr4399","url":null,"abstract":"Programming precise and specific microbial intraspecies or interspecies interaction would be powerful for microbial metabolic regulation, signal pathway mechanism understanding, and therapeutic application. However, it is still of great challenge to develop a simple and universal method to artificially encode the microbial interactions without interfering with the intrinsic cell metabolism. Here, we proposed an extensible and flexible framework nucleic acid strategy for encoding the specific and precise microbial interactions upon self-assembly. With this spatial manipulation tool, we propose the microbial spatial heterogeneity and short-range interaction mechanism that the microbial assembly facilitates the gene expressions of the surface sensors including flagella and pili in Pseudomonas aeruginosa, leading to a more sensitive response to quorum sensing. The microbial interaction programming strategy proposed in this work is expected to provide a powerful and designable nanoplatform for better understanding of distance-dependent bacterial communication networks.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"10 50","pages":"eadr4399"},"PeriodicalIF":11.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecularly tailorable metal oxide clusters ensured robust interfacial connection in inverted perovskite solar cells.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-12-13 Epub Date: 2024-12-11 DOI: 10.1126/sciadv.adq1150

Fengzhu Li, Chaowei Zhao, Yanxun Li, Zhen Zhang, Xiaofeng Huang, Yuefeng Zhang, Jie Fang, Tieyuan Bian, Zhiyuan Zeng, Jun Yin, Alex K-Y Jen

{"title":"Molecularly tailorable metal oxide clusters ensured robust interfacial connection in inverted perovskite solar cells.","authors":"Fengzhu Li, Chaowei Zhao, Yanxun Li, Zhen Zhang, Xiaofeng Huang, Yuefeng Zhang, Jie Fang, Tieyuan Bian, Zhiyuan Zeng, Jun Yin, Alex K-Y Jen","doi":"10.1126/sciadv.adq1150","DOIUrl":"10.1126/sciadv.adq1150","url":null,"abstract":"Interfacial recombination and ion migration between perovskite and electron-transporting materials have been the persisting challenges in further improving the efficiency and stability of perovskite solar cells (PVSCs). Here, we design a series of molecularly tailorable clusters as an interlayer that can simultaneously enhance the interaction with C60 and perovskite. These clusters have precisely controlled structures, decent charge carrier mobility, considerable solubility, suitable energy levels, and functional ligands, which can help passivate perovskite surface defects, form a uniform capping net to immobilize C60, and build a robust coupling between perovskite and C60. The target inverted PVSCs achieve an impressive power conversion efficiency (PCE) of 25.6% without the need for additional surface passivation. Crucially, the unencapsulated device displays excellent stability under light, heat, and bias, maintaining 98% of its initial PCE after 1500 hours of maximum power point tracking. These results show great promise in the development of advanced interfacial materials for highly efficient perovskite photovoltaics.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"10 50","pages":"eadq1150"},"PeriodicalIF":11.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perceptual constancy for an odor is acquired through changes in primary sensory neurons.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-12-13 Epub Date: 2024-12-11 DOI: 10.1126/sciadv.ado9205

Mark Conway, Merve Oncul, Kate Allen, Zongqian Zhang, Jamie Johnston

引用次数: 0

The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-12-13 Epub Date: 2024-12-11 DOI: 10.1126/sciadv.adp7444

Pooja Patel, Arielys Mendoza, Daniel Ramirez, Dexter Robichaux, Jeffery D Molkentin, Jason Karch

{"title":"The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.","authors":"Pooja Patel, Arielys Mendoza, Daniel Ramirez, Dexter Robichaux, Jeffery D Molkentin, Jason Karch","doi":"10.1126/sciadv.adp7444","DOIUrl":"10.1126/sciadv.adp7444","url":null,"abstract":"The mitochondrial permeability transition pore (mPTP) is implicated in cardiac ischemia-reperfusion (I/R) injury. During I/R, elevated mitochondrial Ca2+ triggers mPTP opening, leading to necrotic cell death. Although nonessential regulators of this pore are characterized, the molecular identity of the pore-forming component remains elusive. Two of these genetically verified regulators are cyclophilin D (CypD) and the adenine nucleotide translocase (ANT) family. We investigated the ANT/CypD relationship in mPTP dynamics and I/R injury. Despite lacking all ANT isoforms, Ca2+-dependent mPTP opening persisted in cardiac mitochondria but was desensitized. This desensitization conferred resistance to I/R injury in ANT-deficient mice. CypD is hypothesized to trigger mPTP opening through isomerization of ANTs at proline-62. To test this, we generated mice that expressed a P62A mutated version of ANT1. These mice showed similar mPTP dynamics and I/R sensitivity as the wild type, indicating that P62 is dispensable for CypD regulation. Together, these data indicate that the ANT family contributes to mPTP opening independently of CypD.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"10 50","pages":"eadp7444"},"PeriodicalIF":11.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The frontiers of chemical imaging.

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-12-13 Epub Date: 2024-12-11 DOI: 10.1126/sciadv.adu9069

Ji-Xin Cheng, Warren S Warren

引用次数: 0

The recombination efficiency of the bacterial integron depends on the mechanical stability of the synaptic complex

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-13 DOI: 10.1126/sciadv.adp8756

Ekaterina Vorobevskaia, Céline Loot, Didier Mazel, Michael Schlierf

{"title":"The recombination efficiency of the bacterial integron depends on the mechanical stability of the synaptic complex","authors":"Ekaterina Vorobevskaia, Céline Loot, Didier Mazel, Michael Schlierf","doi":"10.1126/sciadv.adp8756","DOIUrl":"https://doi.org/10.1126/sciadv.adp8756","url":null,"abstract":"Multiple antibiotic resistances are a major global health threat. The predominant tool for adaptation in Gram-negative bacteria is the integron. Under stress, it rearranges gene cassettes to offer an escape using the tyrosine recombinase IntI, recognizing folded DNA hairpins, the attC sites. Four recombinases and two attC sites form the synaptic complex. Yet, for unclear reasons, the recombination efficiency varies greatly. Here, we established an optical tweezers force spectroscopy assay to probe the synaptic complex stability and revealed, for seven combinations of attC sites, significant variability in the mechanical stability. We found a strong correlation between mechanical stability and recombination efficiency of attC sites in vivo, indicating a regulatory mechanism from the DNA structure to the macromolecular complex stability. Taking into account known forces during DNA metabolism, we propose that the variation of the integron in vivo recombination efficiency is mediated by the synaptic complex stability. We anticipate that further recombination processes are also affected by their corresponding mechanical stability.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-13 DOI: 10.1126/sciadv.adf8405

Xiaofeng Xu, Minxi Fang, Lixia Chen, Hao Huang, Zhong-Min Dai, Junlin Yang, Mengsheng Qiu

{"title":"Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation","authors":"Xiaofeng Xu, Minxi Fang, Lixia Chen, Hao Huang, Zhong-Min Dai, Junlin Yang, Mengsheng Qiu","doi":"10.1126/sciadv.adf8405","DOIUrl":"https://doi.org/10.1126/sciadv.adf8405","url":null,"abstract":"Proper axonal myelination and function of the vertebrate central nervous system rely largely on the timely differentiation of oligodendrocytes (OLs), yet key regulatory factors remain enigmatic. Our study reveals neural zinc finger (Nzf2) as a crucial orchestrator that controls the timing of OL differentiation both during development and myelin repair, contrasting with its previously suggested role in direct myelin gene regulation. Nzf2 ablation delays the onset of OL differentiation, while hyperactivation stimulates OL differentiation both during development and remyelination. Using RNA-seq and ChIP-seq, we pinpoint Nkx2.2 as a critical downstream target of Nzf2. Specific binding of Nzf2 in the Nkx2.2 gene locus inhibits histone deacetylation by disrupting the HDAC1 repressor complex and reducing deacetylase activity. Furthermore, Nzf2 overrides the inhibitory Notch signaling to initiate OL differentiation. Thus, we propose that the Notch-Nzf2-Nkx2.2 axis is a vital component of OL differentiation timing mechanism, suggesting Nzf2 as a potential therapeutic target for stimulating OL differentiation and boosting myelin repair in demyelinating diseases.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"84 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-13 DOI: 10.1126/sciadv.adm7928

Shuyi Li, Zhi-Cheng Yao, Hanzhi Wang, Jonathan A. Ecker, Mary O. Omotoso, Jaechan Lee, Jiayuan Kong, Hexiang Feng, Worarat Chaisawangwong, Si-Sim Kang, Sydney R. Shannon, Natalie K. Livingston, Joan G. Bieler, Shweta Singh, Maya L. Zhang, Pilar O’Neal, Emily Ariail, Benjamin Biggs, John W. Hickey, Hai-Quan Mao, Jonathan P. Schneck

{"title":"Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy","authors":"Shuyi Li, Zhi-Cheng Yao, Hanzhi Wang, Jonathan A. Ecker, Mary O. Omotoso, Jaechan Lee, Jiayuan Kong, Hexiang Feng, Worarat Chaisawangwong, Si-Sim Kang, Sydney R. Shannon, Natalie K. Livingston, Joan G. Bieler, Shweta Singh, Maya L. Zhang, Pilar O’Neal, Emily Ariail, Benjamin Biggs, John W. Hickey, Hai-Quan Mao, Jonathan P. Schneck","doi":"10.1126/sciadv.adm7928","DOIUrl":"https://doi.org/10.1126/sciadv.adm7928","url":null,"abstract":"Tissue-resident memory T (T RM ) cells preferentially reside in peripheral tissues, serving as key players in tumor immunity and immunotherapy. The lack of effective approaches for expanding T RM cells and delivering these cells in vivo hinders the exploration of T RM cell–mediated cancer immunotherapy. Here, we report a nanoparticle artificial antigen-presenting cell (nano-aAPC) ex vivo expansion approach and an in vivo delivery system for T RM cells. Using the nano-aAPC platform, we expanded functional antigen-specific murine and human T RM -like CD8 + T cells ex vivo. We also developed an injectable macroporous hyaluronic acid (HA) hydrogel to deliver T RM -like cells. T RM -like cells delivered in the optimized HA hydrogel trigger robust local and systemic antitumor immunity and show synergistic effects with anti–PD-1 treatment. Our findings suggest that nano-aAPC–induced T RM -like cells, coupled with a hydrogel delivery system, offer an efficient way to advance the understanding of T RM cell–mediated cancer therapy.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"119 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0