Science Advances最新文献_第4页

Role of HAUS7 as a DOCK3 binding partner in facilitating axon regeneration HAUS7作为DOCK3结合伙伴在促进轴突再生中的作用

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adq7105

Naoki Kiyota, Youichi Shinozaki, Xiaoli Guo, Atsuko Kimura, Kazuto Kawamura, Euido Nishijima, Sari Honda, Chikako Harada, Toru Nakazawa, Kazuhiko Namekata, Takayuki Harada

{"title":"Role of HAUS7 as a DOCK3 binding partner in facilitating axon regeneration","authors":"Naoki Kiyota, Youichi Shinozaki, Xiaoli Guo, Atsuko Kimura, Kazuto Kawamura, Euido Nishijima, Sari Honda, Chikako Harada, Toru Nakazawa, Kazuhiko Namekata, Takayuki Harada","doi":"10.1126/sciadv.adq7105","DOIUrl":"10.1126/sciadv.adq7105","url":null,"abstract":"<div >The molecular mechanisms involved in reconstructing the eye-to-brain connection and functional recovery following optic nerve damage remain unclear. This study revealed that HAUS augmin-like complex subunit 7 (HAUS7) is a molecule that binds to dedicator of cytokinesis 3 (DOCK3), a regulator of neurotrophic factor signaling and axon regeneration. We observed a distribution pattern of HAUS7 expression, suggesting that neuronal HAUS7 is transported from the cell body to the growth cone under the control of DOCK3. In addition, phosphorylation of DOCK3 at Y562 by tropomyosin receptor kinase B signaling leads to the dissociation of HAUS7, which is considered an important step for microtubule assembly. Deletion of <i>Haus7</i> in mice significantly reduced microtubule formation and axon regeneration following optic nerve crush (ONC). Transcriptome analysis suggested that HAUS7 levels decrease in glaucoma and after the ONC, while retinal ganglion cells actively regenerating their axons express high levels of HAUS7. In summary, HAUS7 is a binding partner of DOCK3 necessary for axon elongation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq7105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Correlation of metal anode reversibility with solvation chemistry and interfacial electron transfer in aqueous electrolytes 金属阳极可逆性与水溶液中溶剂化化学和界面电子转移的关系

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adx8413

Yunpei Zhu, Simil Thomas, Tairan Wang, Xianrong Guo, Yizhou Wang, Chen Liu, S. Mani Sarathy, Xixiang Zhang, Osman M. Bakr, Omar F. Mohammed, Husam N. Alshareef

{"title":"Correlation of metal anode reversibility with solvation chemistry and interfacial electron transfer in aqueous electrolytes","authors":"Yunpei Zhu, Simil Thomas, Tairan Wang, Xianrong Guo, Yizhou Wang, Chen Liu, S. Mani Sarathy, Xixiang Zhang, Osman M. Bakr, Omar F. Mohammed, Husam N. Alshareef","doi":"10.1126/sciadv.adx8413","DOIUrl":"10.1126/sciadv.adx8413","url":null,"abstract":"<div >Reversible electrodeposition of metals is a crucial route to developing high-energy and rechargeable batteries. However, uncontrolled and nonplanar morphological evolution and parasitic reactions at the metal anodes are fundamental barriers to realizing full reversibility. Here, using aqueous electrochemistry as a probe, we develop multiscale characterization tools that can precisely determine the root cause of these morphological instabilities and parasitic reactions. Our analysis indicates that these issues are fundamentally from the free water molecules in aqueous electrolytes, leading to low reversibility of metal anodes. We therefore demonstrate a straightforward and effective strategy, based on modulating the solute anions in aqueous electrolytes, to suppress free water molecule concentration in conventional aqueous electrolytes. A proof of concept is demonstrated using a Zn metal anode, which shows unprecedented reversibility and stability in conventional aqueous electrolytes with structure-making anions under a harsh condition of 10 milliampere hours per square centimeter. This work unlocks an alternative angle to develop sustainable electrolytes for cost-efficient, practical battery chemistries.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx8413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Erratum for the Research Article “Gradient double-twisted Bouligand structural design for high impact resistance over a wide range of loading velocities” by S.-M. Wen et al. 研究文章《在大加载速度范围内抗高冲击的梯度双扭布利甘结构设计》的勘误。温等人。

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.aea0930

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Thermoresponsive antioxidant metal-free carbon nanodot hydrogel: An effective therapeutic approach for ocular surface disease 热响应性抗氧化无金属碳纳米点水凝胶：眼表疾病的有效治疗方法

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adt8775

Mei Yang, Xin Chen, Zhongxing Chen, Nan Zhao, Zhenhai Zeng, Xiaomin Huang, Zheng Li, Jiawei Li, Guoli Zhao, Manli Deng, Zhilin Zou, Hongxian Pan, Aodong Chen, Tingting Chen, Yue Wu, Xueyu Fu, Qimanguli Saiding, Na Kong, Wei Tao, Xingtao Zhou, Jinhai Huang

{"title":"Thermoresponsive antioxidant metal-free carbon nanodot hydrogel: An effective therapeutic approach for ocular surface disease","authors":"Mei Yang, Xin Chen, Zhongxing Chen, Nan Zhao, Zhenhai Zeng, Xiaomin Huang, Zheng Li, Jiawei Li, Guoli Zhao, Manli Deng, Zhilin Zou, Hongxian Pan, Aodong Chen, Tingting Chen, Yue Wu, Xueyu Fu, Qimanguli Saiding, Na Kong, Wei Tao, Xingtao Zhou, Jinhai Huang","doi":"10.1126/sciadv.adt8775","DOIUrl":"10.1126/sciadv.adt8775","url":null,"abstract":"<div >Oxidative stress, an imbalance between the body’s oxidative and antioxidant systems, contributes markedly to the development of numerous ocular surface diseases, particularly dry eye disease (DED). Effective elimination or reduction of reactive oxygen species (ROS) can halt disease progression and alleviate symptoms. This study presents an innovative thermoresponsive, metal-free carbon nanodot (CD) hydrogel, termed F-CD hydrogel, which exhibits potent neutralization capabilities against multiple free radicals, including OH·, O<sub>2</sub><sup>−</sup>·, and ·DPPH. This hydrogel demonstrates remarkable antioxidant, anti-inflammatory, and antiapoptotic capacity, effectively relieving DED symptoms by eliminating ROS at their source. Furthermore, its thermosensitive characteristics enhance the adherence of CDs to the ocular surface. In mouse models of DED, the F-CD hydrogel accelerates epithelial repair, thickens the corneal epithelium, promotes tear secretion, and boosts goblet cell count by up-regulating protective genes while suppressing those promoting apoptosis and oxidative stress. Coupled with its excellent biocompatibility and reduced administration frequency and treatment duration, the F-CD hydrogel emerges as a promising therapeutic approach for DED.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt8775","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neanderthals, hypercarnivores, and maggots: Insights from stable nitrogen isotopes 尼安德特人、超级食肉动物和蛆：来自稳定氮同位素的见解

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adt7466

Melanie M. Beasley, Julie J. Lesnik, John D. Speth

{"title":"Neanderthals, hypercarnivores, and maggots: Insights from stable nitrogen isotopes","authors":"Melanie M. Beasley, Julie J. Lesnik, John D. Speth","doi":"10.1126/sciadv.adt7466","DOIUrl":"10.1126/sciadv.adt7466","url":null,"abstract":"<div >Reconstructions of Eurasian Neanderthal diets based on stable nitrogen isotope ratios (δ<sup>15</sup>N) typically place hominins at the top of the food web, together with, or above, hypercarnivores, such as lions and wolves. We suggest that these high δ<sup>15</sup>N values may, in part, reflect the regular consumption of <sup>15</sup>N-enriched fly larvae (maggots) occurring in stored animal foods. The ethnohistoric record contains countless examples of Indigenous peoples routinely consuming putrefied animal foods with maggots. Here, we report the results of δ<sup>15</sup>N bulk analyses of fly larvae of three families (Diptera: Brachycera: Calliphoridae, Piophilidae, and Stratiomyidae) collected from putrefying carcasses. Putrefaction led to modest changes in the initial muscle tissue δ<sup>15</sup>N values that ranged from −0.6 to 7.7‰. Much greater δ<sup>15</sup>N values ranging from 5.4 to 43.2‰ were observed in the fly larvae associated with putrefaction. We suggest that frequent consumption of animal foods laced with maggots should be considered as a contributor to the high δ<sup>15</sup>N values observed in Late Pleistocene hominins.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt7466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Starfish-inspired tube feet for temporary and switchable underwater adhesion and transportation 海星启发的管脚，用于临时和可切换的水下粘附和运输

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adx3539

Hyemin Lee, Yerin Ryu, Yejin Oh, Chorong Kim, Yoonjin Lee, Hyewon Choi, Jaekyoung Kim, Ji Hoon Kim, Jiwan Kang, Keun Park, Kevin T. Turner, Shu Yang, Hyunsik Yoon

{"title":"Starfish-inspired tube feet for temporary and switchable underwater adhesion and transportation","authors":"Hyemin Lee, Yerin Ryu, Yejin Oh, Chorong Kim, Yoonjin Lee, Hyewon Choi, Jaekyoung Kim, Ji Hoon Kim, Jiwan Kang, Keun Park, Kevin T. Turner, Shu Yang, Hyunsik Yoon","doi":"10.1126/sciadv.adx3539","DOIUrl":"10.1126/sciadv.adx3539","url":null,"abstract":"<div >Temporary and reversible underwater adhesion is important for a number of robotic applications, including picking up objects, facilitating locomotion in confined environments, and attaching to surfaces during periods of observation. Here, we present a starfish-inspired tube foot composed of a soft hydrogel mouth and a rigid stem, fabricated by integrating two serially bonded cylindrical components with distinct mechanical properties. Upon swelling, the initially straight hydrogel cylinder undergoes a selective shape transformation into a soft, cupped pad that deforms to stretch and spread upon contact, enabling effective adhesion to target surfaces. During detachment, a vacuum is formed within the tube, leading to strong underwater adhesion. The artificial tube feet show high adhesion hysteresis, autonomous release by external stimuli, and immediate detachment by pneumatic actuation with integrated system. The temporary underwater adhesive inspired by the tube feet of starfish enables functionality in underwater robotics and is demonstrated through underwater manipulation of rocks.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx3539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Ultrahigh-resolution solid-state NMR for high–molecular weight proteins on GHz-class spectrometers 高分子量蛋白质在ghz级光谱仪上的超高分辨率固态核磁共振

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adx6016

Songlin Wang, Thirupathi Ravula, John A. Stringer, Peter L. Gor’kov, Owen A. Warmuth, Christopher G. Williams, Alex F. Thome, Leonard J. Mueller, Chad M. Rienstra

{"title":"Ultrahigh-resolution solid-state NMR for high–molecular weight proteins on GHz-class spectrometers","authors":"Songlin Wang, Thirupathi Ravula, John A. Stringer, Peter L. Gor’kov, Owen A. Warmuth, Christopher G. Williams, Alex F. Thome, Leonard J. Mueller, Chad M. Rienstra","doi":"10.1126/sciadv.adx6016","DOIUrl":"10.1126/sciadv.adx6016","url":null,"abstract":"<div >Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique with broad impact across the physical and life sciences, and ultrahigh field (UHF), gigahertz-class NMR spectrometers offer exceptional performance, including superior resolution and sensitivity. In solid-state NMR (SSNMR), resolution is primarily constrained by instrumentation rather than molecular tumbling, making it well suited for studying large and complex systems. To fully leverage UHF magnets for SSNMR, it is essential to eliminate line broadening arising from magnetic field drift and couplings among the nuclear spins. We address these challenges using external <sup>2</sup>H lock to compensate for the field drift and long-observation-window band-selective homonuclear decoupling to suppress <sup>13</sup>C homonuclear couplings. We achieve better than 0.2–parts per million resolution in proteins up to 144 kilodalton, enabling unique site resolution for more than 500 amide backbone pairs in two-dimensional experiments. This exceeds the resolution available from solution NMR for large biological molecules, greatly expanding the potential of gigahertz-class NMR for research in life sciences.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx6016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multienergy x-ray detection and imaging enabled by working voltage regulating unipolar carrier collection in perovskite detectors 在钙钛矿探测器中通过工作电压调节单极载流子收集实现多能x射线探测和成像

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.ads2995

Yuwei Li, Xin Wang, Yijing Ding, Jingda Zhao, Shilin Liu, Yubing Xu, Qi Cheng, Ziyu Wei, Damian Chinedu Onwudiwe, Byung Seong Bae, Mehmet Ertuğrul, Ying Zhu, Wenbo Ma, Yang (Michael) Yang, Wei Lei, Xiaobao Xu

{"title":"Multienergy x-ray detection and imaging enabled by working voltage regulating unipolar carrier collection in perovskite detectors","authors":"Yuwei Li, Xin Wang, Yijing Ding, Jingda Zhao, Shilin Liu, Yubing Xu, Qi Cheng, Ziyu Wei, Damian Chinedu Onwudiwe, Byung Seong Bae, Mehmet Ertuğrul, Ying Zhu, Wenbo Ma, Yang (Michael) Yang, Wei Lei, Xiaobao Xu","doi":"10.1126/sciadv.ads2995","DOIUrl":"10.1126/sciadv.ads2995","url":null,"abstract":"<div >Multienergy x-ray imaging can provide additional substance information beyond morphology in conventional energy-integration imaging. The predominant approach, single photon counting, sets stringent requirements on low x-ray flux and signal discrimination and prolongs imaging time. Here, we report on the design of unipolar n-i-n perovskite detectors for multienergy x-ray imaging. Systematic characterization validates electrons dominating carrier dynamics in detectors, and the distribution of generated electrons varies as x-ray energy along its penetrating direction, whereas working voltage can manipulate electron drift length, ensuring their selective collection for x-ray energy discrimination. Our multienergy imaging array adopts high-flux x-ray in a normal imaging system and realizes fast 4-energy-bins x-ray images. By introducing the σ(<i>E<sub>i</sub></i>)/σ(<i>E<sub>j</sub></i>)-related multienergy digital subtraction algorithm, the images successfully distinguish the substance of targets side by side or by stacking, representing a notable advancement over conventional energy-integration imaging technique.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads2995","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic history of Scythia Scythia的遗传史

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.ads8179

Tatiana V. Andreeva, Anna D. Soshkina, Fedor E. Gusev, Alexandra B. Malyarchuk, Gleb S. Dotsenko, Natalia A. Dudko, Maria Yu. Plotnikova, Svetlana S. Kunizheva, Andrey D. Manakhov, Tatiana V. Ustkachkintseva, Maria S. Protasova, Semyon A. Volodin, Alexandra P. Buzhilova, Yuriy D. Razuvaev, Natalia Ya. Berezina, Yakov B. Berezin, Anatoly R. Kantorovich, Vladimir E. Maslov, Dmitry G. Barinov, Maria V. Dobrovolskaya, Evgeny I. Rogaev

{"title":"Genetic history of Scythia","authors":"Tatiana V. Andreeva, Anna D. Soshkina, Fedor E. Gusev, Alexandra B. Malyarchuk, Gleb S. Dotsenko, Natalia A. Dudko, Maria Yu. Plotnikova, Svetlana S. Kunizheva, Andrey D. Manakhov, Tatiana V. Ustkachkintseva, Maria S. Protasova, Semyon A. Volodin, Alexandra P. Buzhilova, Yuriy D. Razuvaev, Natalia Ya. Berezina, Yakov B. Berezin, Anatoly R. Kantorovich, Vladimir E. Maslov, Dmitry G. Barinov, Maria V. Dobrovolskaya, Evgeny I. Rogaev","doi":"10.1126/sciadv.ads8179","DOIUrl":"10.1126/sciadv.ads8179","url":null,"abstract":"<div >Great Scythia was the ancient Greek name for the area stretching from the northern Black Sea coast to the Middle Don. Using high-quality genomic data generated from 131 ancient individuals from Great Scythia and neighboring regions of the Bronze Age and the Iron Age, we established the genetic structure of the Scythians, revealing their diverse origin with major European Bronze Age ancestral components, and genetic traces of migration and invasions. We uncovered relationships between Scythians, including elite Scythians. Substantial endogamy in the Scythian clan was found. We examined Scythians’ phenotypes and medical-genetic background and found a harmful gene mutation causing fructose intolerance. This ancient “Scythian” mutation has spread throughout West Eurasia and has become the most prevalent genetic cause of fructose intolerance in contemporary European populations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads8179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine 腹侧苍白部谷氨酸能厌恶网络编码对可卡因的戒断和再暴露

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-23 DOI: 10.1126/sciadv.adu6074

Liran A. Levi, Kineret Inbar, Esti Tseiger, Yonatan M. Kupchik

{"title":"A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine","authors":"Liran A. Levi, Kineret Inbar, Esti Tseiger, Yonatan M. Kupchik","doi":"10.1126/sciadv.adu6074","DOIUrl":"10.1126/sciadv.adu6074","url":null,"abstract":"<div >Relapse to drugs of abuse can occur after long periods of abstinence. The ventral pallidum (VP) is central to drug addiction, and its glutamatergic neurons (VP<sub>Glu</sub>), whose activation drives aversion, inhibit drug seeking. However, it remains unknown whether these neurons encode the abstinence from and relapse to drugs. We show here that VP<sub>Glu</sub> projections specifically to the aversion-related lateral habenula (LHb) and ventral tegmental area gabaergic (VTA<sub>GABA</sub>) neurons show plasticity induced by abstinence from and reexposure to cocaine or cocaine cues. Both these pathways potentiate during abstinence and restore baseline values upon drug reexposure but with different plasticity mechanisms. Last, inhibiting the VP<sub>Glu</sub> → LHb pathway enhances cocaine preference after abstinence, while inhibiting the VP<sub>Glu</sub> → VTA pathway shows variable effects. These findings establish an aversive circuit orchestrated by VP<sub>Glu</sub> neurons encoding long-term abstinence-driven changes that may contribute to drug relapse.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu6074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0