Science Advances最新文献_第4页

Single-cell–level digital twins for preterm birth prevention strategies 单细胞水平的数字双胞胎用于早产预防策略

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aed2741

Jakob Einhaus, Peter Neidlinger, Olivier Fondeur, Masaki Sato, Sasha Anronikov, Kotaro Miyazaki, Antoine Maechler, Jonas N. Amar, Kazuo Ando, Valentin Badea, Dyani K. Gaudilliere, Maximilian Sabayev, Dorien Feyaerts, Maïgane Diop, Amy S. Tsai, Amelie Cambriel, Edward A. Ganio, Romain Lagarde, Emmeline O’Kelly, Ina A. Stelzer, Julien Hedou, Ronald J. Wong, Yair J. Blumenfeld, Deirdre J. Lyell, Gary M. Shaw, Tomiko T. Oskotsky, Marina Sirota, Linda C. Giudice, David K. Stevenson, Nima Aghaeepour, Brice Gaudilliere

{"title":"Single-cell–level digital twins for preterm birth prevention strategies","authors":"Jakob Einhaus, Peter Neidlinger, Olivier Fondeur, Masaki Sato, Sasha Anronikov, Kotaro Miyazaki, Antoine Maechler, Jonas N. Amar, Kazuo Ando, Valentin Badea, Dyani K. Gaudilliere, Maximilian Sabayev, Dorien Feyaerts, Maïgane Diop, Amy S. Tsai, Amelie Cambriel, Edward A. Ganio, Romain Lagarde, Emmeline O’Kelly, Ina A. Stelzer, Julien Hedou, Ronald J. Wong, Yair J. Blumenfeld, Deirdre J. Lyell, Gary M. Shaw, Tomiko T. Oskotsky, Marina Sirota, Linda C. Giudice, David K. Stevenson, Nima Aghaeepour, Brice Gaudilliere","doi":"10.1126/sciadv.aed2741","DOIUrl":"https://doi.org/10.1126/sciadv.aed2741","url":null,"abstract":"Digital twin models can accelerate therapeutic development by enabling low-risk testing of candidate interventions. In preterm labor (PTL), a major pregnancy complication where clinical trials face ethical and financial barriers, digital twins are especially valuable for evaluating new therapies targeting immune dysfunctions driving PTL. Yet, current models lack single-cell resolution, limiting detection of cell type–specific mechanisms, off-target effects, and the design of personalized interventions. We present Simulated Immunome Modeling of Clinical Outcomes (SIMCO), a single-cell–level digital twin framework that models immunomodulatory treatment effects on the timing of labor using immunome-wide, single-cell simulations. SIMCO’s digital twins are trained and validated on a newly generated mass cytometry atlas of the pregnant immunome exposed to nine candidate drugs preselected for PTL prevention. Applying SIMCO to an independent cohort of pregnant individuals, we simulate treatment effects on gestational length, screening for candidate drugs that delay labor timing and providing system-level mechanistic insight for each drug candidate. Tetrahydrofolate and the combination of aspirin and lansoprazole emerged as top candidates for PTL prevention, delaying labor onset primarily through enhanced mTOR signaling in innate immune cells and attenuated JAK/STAT signaling in naïve CD4 + T cells.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"13 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anomalous phonon selection rules and Raman optical activity in RuO 2 ruo2中异常声子选择规则和拉曼光学活度

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aeh0887

Di Cheng, Ao Wu, Hui Pan, Yu-Peng Zhu, Shizhuo Luo, King Yau Yip, Wei Zhang, Ariando Ariando, Chang Liu, Jian-Sheng Wang, Xinwei Li

{"title":"Anomalous phonon selection rules and Raman optical activity in RuO 2","authors":"Di Cheng, Ao Wu, Hui Pan, Yu-Peng Zhu, Shizhuo Luo, King Yau Yip, Wei Zhang, Ariando Ariando, Chang Liu, Jian-Sheng Wang, Xinwei Li","doi":"10.1126/sciadv.aeh0887","DOIUrl":"https://doi.org/10.1126/sciadv.aeh0887","url":null,"abstract":"Breakdown of selection rules and emergence of optical activity in Raman spectroscopy typically signal symmetry-breaking events essential for understanding novel phases of solids. Here, we apply our recently developed rotational anisotropy Raman spectroscopy technique to single-crystal ruthenium dioxide—a compound of recent interest as a candidate workhorse material for altermagnetism yet whose magnetic ground state remains under intense debate. Our data reveal a salient breakdown of selection rules for zone-center phonons, accompanied by clear splitting in the angle-dependent polarimetry plots for the two opposite helicity-nonconserving circularly polarized scattering channels. These observations provide definitive evidence of a previously overlooked symmetry-breaking event, involving either spatial or time-reversal symmetry. In either scenario, the underlying mechanism is likely a bulk hidden order parameter, potentially involving multipole moments of Ruthenium(IV) set by the local crystal field environment. Our work demonstrates how subtle symmetry-breaking events can manifest through lattice dynamics and calls for renewed experimental and theoretical efforts to map the phase diagram of ruthenium dioxide as a system poised near quantum phase transition boundaries.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"19 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Submesoscale feedback suppresses marine heatwaves 亚中尺度反馈抑制海洋热浪

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aei4624

Jihai Dong, Wenjin Sun, Baylor Fox-Kemper, Zhiyou Jing, Changming Dong

引用次数: 0

Observations show increased nitrate in coastal cloud droplet residuals from large-particle activation and N 2 O 5 hydrolysis 观测结果表明，大颗粒活化和n2o水解使沿海云滴残留物中硝酸盐含量增加

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aei3465

Abigail S. Williams, Lynn M. Russell, Sanghee Han, Veronica Z. Berta, Jeramy L. Dedrick, Teresa Campos, Lauren T. Robinson, Rachel Y.-W. Chang, Ryan N. Farley, Allison C. Aiken, Cynthia H. Twohy, Michael J. Wheeler, Jeremy J. B. Wentzell, John Liggio

{"title":"Observations show increased nitrate in coastal cloud droplet residuals from large-particle activation and N 2 O 5 hydrolysis","authors":"Abigail S. Williams, Lynn M. Russell, Sanghee Han, Veronica Z. Berta, Jeramy L. Dedrick, Teresa Campos, Lauren T. Robinson, Rachel Y.-W. Chang, Ryan N. Farley, Allison C. Aiken, Cynthia H. Twohy, Michael J. Wheeler, Jeremy J. B. Wentzell, John Liggio","doi":"10.1126/sciadv.aei3465","DOIUrl":"https://doi.org/10.1126/sciadv.aei3465","url":null,"abstract":"Clouds change the chemical composition of aerosols, yet observations characterizing these processes are quite limited. Ground-based in-cloud measurements in coastal Southern California show that the highest nitrate to sulfate ratio (2.5 ± 1.7) in droplet residuals is near cloud base where cloud liquid water content and droplet number concentration are below the observed 20th percentile. The number size distribution of nitrate-rich particles peaks at a larger diameter than sulfate-rich particles, supporting growth to droplets of nitrate-rich particles at lower supersaturations than for sulfate-rich particles. Nitrate mass concentrations are up to three times higher in-cloud compared to pre-cloud and correlated with statistically significant reductions in ozone concentrations, consistent with contributions from in-cloud nitrate formation by N 2 O 5 hydrolysis. This study provides quantitative relationships of cloud properties to nitrate production in droplet residuals and associated ozone reduction, illustrating the impacts of aqueous reactions in clouds.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"2 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How high-pressure ices on large ocean worlds can support habitability: The compatibility of amino acids into ice VI and VII 大型海洋世界上的高压冰如何支持可居住性：氨基酸与冰VI和冰VII的相容性

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aec2045

Jihua Hao, Can Liu, Feixiang Liu, Chengtao Zhang, Javed Akhter Mondal, Christopher R. Glein, Herve Cardon, Gilles Montagnac, Xiaobin Cao, Isabelle Daniel

{"title":"How high-pressure ices on large ocean worlds can support habitability: The compatibility of amino acids into ice VI and VII","authors":"Jihua Hao, Can Liu, Feixiang Liu, Chengtao Zhang, Javed Akhter Mondal, Christopher R. Glein, Herve Cardon, Gilles Montagnac, Xiaobin Cao, Isabelle Daniel","doi":"10.1126/sciadv.aec2045","DOIUrl":"https://doi.org/10.1126/sciadv.aec2045","url":null,"abstract":"Water oceans in large icy moons and exoplanets are isolated from the rocky interior by thick layers of high-pressure ice, which hinder the direct release of nutrients and organics derived from water-rock interaction to the ocean. Possible uptake of these bio-essential compounds into high-pressure ice phases could regulate their availability in the ocean, but this process is poorly constrained. Here, we measured partition coefficients of glycine and alanine into ices VI and VII under elevated temperature-pressure conditions using a diamond-anvil cell. We observed moderate compatibility of glycine and alanine with partition coefficients: K p ,glycine = 0.14 and 0.40 in ices VI and VII, respectively; K p ,alanine = 0.21 and 0.35 in ices VI and VII, respectively. First-principles calculations suggested that amino acids could be incorporated into high-pressure ice’s lattice via cogrowth. Compatibility of amino acids into high-pressure ices would favor their transport in large extraterrestrial oceans, opening an avenue to habitability.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"13 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct chalcophile-element inheritance from subducted continental crust in metasomatized mantle 交代地幔中俯冲大陆地壳明显的亲铜元素继承

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aeh0254

Zaicong Wang, Xiang Wang, Haijin Xu, Junbo Zhang, Frances Elaine Jenner, Stephen Foley, Liang Ma, Kang Chen, Jiyao Sun, Keqing Zong, Yongsheng Liu, Jianwei Li, Junfeng Zhang, Zhaochu Hu

{"title":"Distinct chalcophile-element inheritance from subducted continental crust in metasomatized mantle","authors":"Zaicong Wang, Xiang Wang, Haijin Xu, Junbo Zhang, Frances Elaine Jenner, Stephen Foley, Liang Ma, Kang Chen, Jiyao Sun, Keqing Zong, Yongsheng Liu, Jianwei Li, Junfeng Zhang, Zhaochu Hu","doi":"10.1126/sciadv.aeh0254","DOIUrl":"https://doi.org/10.1126/sciadv.aeh0254","url":null,"abstract":"Subduction recycles surface materials into the mantle and shapes its chemical evolution. Whether continental subduction leaves chalcophile-element imprints in the mantle that differ from those of oceanic subduction remains poorly understood. Here, we show that primitive basaltic magmas from the North China Craton exhibit pronounced copper depletion, silver enrichment, and low copper/silver (200 to 1200), together with continental crust–like trace element patterns and radiogenic-isotope compositions. These features contrast sharply with those of the convective mantle, mid-ocean ridge basalts, and oceanic arc basalts, and reflect chemical signatures inherited from subducted continental crust and retained over geological timescales in metasomatized domains of a relatively cold lithospheric mantle. Coupled lead enrichment and unradiogenic lead-isotope signatures further identify metasomatized mantle as an important reservoir of Earth’s unradiogenic lead. Our results reveal distinct modes of chalcophile-element recycling and mantle inheritance during continental and oceanic subduction, with broad implications for mantle chemical evolution and the critical-metal fertility of continental lithosphere.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"75 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpreting the Hall effect of highly doped conducting polymers 解释高掺杂导电聚合物的霍尔效应

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aej6501

Yingqiao Ma, Xinglong Ren, Juncheng Fan, Sebastiaan Hoek, Henning Sirringhaus

{"title":"Interpreting the Hall effect of highly doped conducting polymers","authors":"Yingqiao Ma, Xinglong Ren, Juncheng Fan, Sebastiaan Hoek, Henning Sirringhaus","doi":"10.1126/sciadv.aej6501","DOIUrl":"https://doi.org/10.1126/sciadv.aej6501","url":null,"abstract":"Accurate determination of carrier density and mobility is fundamental to understanding the transport physics of conducting polymers and optimizing their performance. However, Hall effect measurements, widely used for determining carrier concentrations in other materials, have been of limited use for conducting polymers. Applying the conventional Hall coefficient expression ( <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" display=\"inline\" overflow=\"scroll\"> <mml:mrow> <mml:msub> <mml:mi>R</mml:mi> <mml:mi mathvariant=\"normal\">H</mml:mi> </mml:msub> <mml:mo>=</mml:mo> <mml:msup> <mml:mrow> <mml:mo stretchy=\"true\">[</mml:mo> <mml:msub> <mml:mi>n</mml:mi> <mml:mi mathvariant=\"normal\">H</mml:mi> </mml:msub> <mml:mi>q</mml:mi> <mml:mo stretchy=\"true\">]</mml:mo> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> ) consistently yields unphysically high carrier densities in heavily doped polymers. Here, we resolve this problem using a quasi–one-dimensional (Q1D) tight-binding model of the band structure of uniaxially aligned polymer films to analyze the p-type to n-type transition in the Hall effect observed upon increased doping. Our Q1D framework achieves excellent agreement between Hall-derived carrier densities and other independent measurements over a wide doping range. Our findings indicate that the transport physics of aligned polymers is governed by the topology of a single Q1D band within a simple band-filling framework and establish Hall measurements as a powerful tool for studying their charge transport physics.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"237 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonic metamaterial at MHz frequencies using microstructured glass 利用微结构玻璃在兆赫频率下制造超声波超材料

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aef0666

Oscar Demeulenaere, Nikita Ustimenko, Athanasios G. Athanassiadis, Lovish Gulati, Carsten Rockstuhl, Peer Fischer

{"title":"Ultrasonic metamaterial at MHz frequencies using microstructured glass","authors":"Oscar Demeulenaere, Nikita Ustimenko, Athanasios G. Athanassiadis, Lovish Gulati, Carsten Rockstuhl, Peer Fischer","doi":"10.1126/sciadv.aef0666","DOIUrl":"https://doi.org/10.1126/sciadv.aef0666","url":null,"abstract":"Acoustic metamaterials enhance traditional material properties, providing opportunities to shape sound fields in applications ranging from biomedical imaging and clinical therapy to nondestructive testing. However, at the megahertz frequency range, only a few metamaterial architectures exist. They are often highly attenuating or difficult to manufacture and generally provide limited control. Here, we introduce a megahertz-frequency ultrasonic metamaterial based on laser-engraved glass. By structuring metavoxels with different engraving patterns, we define an anisotropic metamaterial exhibiting local variations in the sound speed of up to 20% compared to unstructured glass and losses 100× lower than in comparable three-dimensional–printed metamaterials. We use this metamaterial to define a library of standard elements that can be modularly combined to shape complex-patterned ultrasonic fields. Our experiments are supported by a theoretical model, which provides additional insights into the microstructural origin of the metamaterial behavior and opens the door to designing tailored ultrasound fields and responses.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"20 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential sex-dependent responses of circulating steroid hormones and cortical gene expression in a traumatic brain injury model 创伤性脑损伤模型中循环类固醇激素和皮质基因表达的性别依赖性差异反应

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aei5171

Amberlyn Simmons, Sierra F. Wilferd, Sofia Campagnuolo, Veronica Pena, Heather Bimonte-Nelson, Jason Newbern, Rachael W. Sirianni, Christopher L. Plaisier, Sarah E. Stabenfeldt

{"title":"Differential sex-dependent responses of circulating steroid hormones and cortical gene expression in a traumatic brain injury model","authors":"Amberlyn Simmons, Sierra F. Wilferd, Sofia Campagnuolo, Veronica Pena, Heather Bimonte-Nelson, Jason Newbern, Rachael W. Sirianni, Christopher L. Plaisier, Sarah E. Stabenfeldt","doi":"10.1126/sciadv.aei5171","DOIUrl":"https://doi.org/10.1126/sciadv.aei5171","url":null,"abstract":"Accumulating evidence supports sex differences in traumatic brain injury (TBI) outcomes. However, the underlying processes that lead to sex differences are not well understood. TBI results in the initiation of molecular and cellular responses that facilitate the progression of neurodegeneration. Little is known about how the circulating hormone profile is altered in response to TBI and whether sex differences in endocrine responses might shape secondary injury pathologies. Using intact male and female mice in a preclinical TBI model, we assessed changes in plasma hormone concentrations and cortical gene expression at 24 and 72 hours after TBI. We demonstrate that males and females exhibit sex-specific alterations in circulating levels of testosterone, androstenedione, estradiol, and dehydroepiandrosterone (DHEA) in response to TBI. We also identified sex differences in the expression of genes that are involved in immune responses and tissue remodeling after injury. Moreover, we report divergent circulating hormone and gene expression correlations between sexes.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"89 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building digital pregnancies from the single cell up 从单细胞开始构建数字怀孕

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2026-10-21 DOI: 10.1126/sciadv.aen0211

Adrienne K. Scott

引用次数: 0