Science Advances最新文献_第4页

Circularly polarized thermal emission driven by chiral flatbands in monoclinic metasurfaces 单斜超表面中手性平带驱动的圆极化热发射

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adw0986

Kaili Sun, Bingxiong Yang, Yangjian Cai, Yuri Kivshar, Zhanghua Han

{"title":"Circularly polarized thermal emission driven by chiral flatbands in monoclinic metasurfaces","authors":"Kaili Sun, Bingxiong Yang, Yangjian Cai, Yuri Kivshar, Zhanghua Han","doi":"10.1126/sciadv.adw0986","DOIUrl":"10.1126/sciadv.adw0986","url":null,"abstract":"<div >Achieving circularly polarized thermal emissions with high spatiotemporal coherence using planar structures has long been considered to be elusive. Here, we use nonlocal metasurfaces with monoclinic lattices that break mirror symmetry to efficiently achieve circularly polarized thermal emissions with both high temporal and spatial coherence. We design a chiral metasurface based on waveguide arrays with periodically shifted segments that have a saddle-shaped chiral and high-<i>Q</i> dispersion band. The parabolic shape along one direction ensures minimum involvement of spatial/Fourier components at each frequency, thereby achieving circularly polarized thermal emission with high spatial coherence. Meanwhile, the flatband behavior along the other direction allows the use of a slot-shaped spatial filter and a mid-infrared lens to collect emissions from large-area metasurfaces, thus improving power collection efficiency without affecting temporal coherence. Our experiments demonstrate circularly polarized thermal emissions with high temporal coherence (<i>Q</i> > 200) and very large circular dichroism (~0.8).</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 31","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw0986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration 初级纤毛GPR161的机械敏感性驱动神经元的跳跃式迁移

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adx3846

Théo Paillard, Ada Allam, Mohamed Doulazmi, Mathieu Hautefeuille, Coralie Fouquet, Liza Sarde, Julie Stoufflet, Salima Messaoudi, Nathalie Spassky, Stéphane Nédélec, Isabelle Dusart, Alain Trembleau, Isabelle Caillé

引用次数: 0

A wearable spatiotemporal controllable ultrasonic device with amyloid-β disaggregation for continuous Alzheimer’s disease therapy 一种用于阿尔茨海默病持续治疗的淀粉样蛋白-β分解可穿戴时空可控超声装置

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adw1732

Faxing Zou, Yibiao Liu, Yong Luo, Tailin Xu

{"title":"A wearable spatiotemporal controllable ultrasonic device with amyloid-β disaggregation for continuous Alzheimer’s disease therapy","authors":"Faxing Zou, Yibiao Liu, Yong Luo, Tailin Xu","doi":"10.1126/sciadv.adw1732","DOIUrl":"10.1126/sciadv.adw1732","url":null,"abstract":"<div >The rising prevalence of Alzheimer’s disease (AD) due to an aging population has made the search for effective treatments more urgent than ever. Previous studies have demonstrated that continuous ultrasound can depolymerize amyloid proteins, offering potential relief from AD. In this study, we present a portable, fully integrated wearable ultrasound system designed to promote amyloid protein depolymerization. The system comprises a flexible honeycomb ultrasonic array patch, a flexible printed circuit, and an interactive terminal control system to facilitate the treatment process. Our results demonstrate that the system effectively reduces amyloid proteins in the brain, improves cognitive function in a familial Alzheimer’s disease (FAD) mouse model, enhances microglial phagocytosis of amyloid-β plaques, and shifts microglia polarization from M1 to M2. These changes contribute to a mitigated inflammatory environment in the brain. This innovative approach may pave the way for noninvasive, personalized treatments for AD, potentially transforming therapeutic strategies in neurodegenerative disorders.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 31","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw1732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology– and adhesion–dual biomimetic nanovaccine boosts antigen cross-presentation through subcellular transport regulation 形态和粘附双重仿生纳米疫苗通过亚细胞运输调节促进抗原交叉递呈

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adx6732

Zhenyu Wang, Huimin Zhou, Qianyi Su, Qinyu Qiu, Wenjia Deng, Miaomiao Zhang, Zhiyong Xu, Jiaxin Li, Jisheng Xiao, Xiaopin Duan

{"title":"Morphology– and adhesion–dual biomimetic nanovaccine boosts antigen cross-presentation through subcellular transport regulation","authors":"Zhenyu Wang, Huimin Zhou, Qianyi Su, Qinyu Qiu, Wenjia Deng, Miaomiao Zhang, Zhiyong Xu, Jiaxin Li, Jisheng Xiao, Xiaopin Duan","doi":"10.1126/sciadv.adx6732","DOIUrl":"10.1126/sciadv.adx6732","url":null,"abstract":"<div >In situ tumor vaccines have immense potential for immunotherapy because they generate whole tumor–derived antigens (TDAs) to activate antitumor immune responses. However, the rapid degradation and clearance of the released TDAs severely hinder subsequent antigen presentation and the final efficacy of the in situ vaccine. Here, we synthesized gold nanoxanthium coated with polydopamine (AuNX-PDA) to mimic the morphological and biological adhesion properties of xanthium and mussels, respectively. AuNX-PDA facilitated effective absorption of released TDAs after near-infrared II photothermal treatment and delivery of the absorbed TDAs to the endoplasmic reticulum and Golgi apparatus of dendritic cells for cross-presentation, thereby activating CD8<sup>+</sup> T cells for efficient tumor-specific immunity. The nanovaccine (NV) significantly inhibited irradiated primary tumors and nonirradiated distant tumors by producing robust antitumor immune responses in B16F10 melanoma and 4T1 breast cancer mouse models. These findings highlight the potency of morphology– and adhesion–dual biomimetic NVs in whole-tumor vaccine therapy.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 31","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx6732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paleoseismic activity in the moon’s Taurus-Littrow valley inferred from boulder falls and landslides 月球上的金牛座-利特罗山谷的古地震活动是从巨石坠落和滑坡中推断出来的

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adu3201

Thomas R. Watters, Nicholas C. Schmerr

引用次数: 0

Ambient catalyst-free conversion of methane to methanol by water radical cations 水自由基在无催化剂环境下将甲烷转化为甲醇

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adw0584

Xiaoping Zhang, Rui Su, Minmin Duan, Xuwen Chen, Bin Jia, Konstantin Chingin, Roman Balabin, Jiang Wang, Wenbo Zhang, Xinglei Zhang, Huanwen Chen

{"title":"Ambient catalyst-free conversion of methane to methanol by water radical cations","authors":"Xiaoping Zhang, Rui Su, Minmin Duan, Xuwen Chen, Bin Jia, Konstantin Chingin, Roman Balabin, Jiang Wang, Wenbo Zhang, Xinglei Zhang, Huanwen Chen","doi":"10.1126/sciadv.adw0584","DOIUrl":"10.1126/sciadv.adw0584","url":null,"abstract":"<div >Methane combustion contributes 30% to global warming, making its conversion to cleaner chemicals a critical challenge. Here, we report a catalyst-free ambient conversion of methane to methanol with a remarkable yield exceeding 650 millimoles per hour and a high conversion rate of ~35%, achieved using in situ–generated water dimer radical cations, <span><math><mrow><msubsup><mrow><mo>(</mo><msub><mi>H</mi><mn>2</mn></msub><mi>O</mi><mo>)</mo></mrow><mn>2</mn><mrow><mo>+</mo><mo>·</mo></mrow></msubsup></mrow></math></span> , in a specially designed batch reactor operating under mild conditions. In a single run, the reactor was typically operated for 10 minutes. The atom efficiency for hydrogen in our approach for methanol synthesis is ~67%. Hydrogen gas is the by-product, produced at a rate of over 2 millimoles per hour. Compared to the previously reported catalytic methods, our production yields are up by between 10<sup>2</sup> and 10<sup>6</sup> times depending on the literature method. This breakthrough enables clean, energy-efficient methane conversion without unwanted oxidation by-products, offering substantial environmental and economic benefits beyond combustion.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 31","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw0584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature extremes impact mortality and morbidity differently 极端温度对死亡率和发病率的影响不同

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adr3070

Carlos F. Gould, Sam Heft-Neal, Alexandra K. Heaney, Eran Bendavid, Christopher W. Callahan, Mathew V. Kiang, Josh Graff Zivin, Marshall Burke

{"title":"Temperature extremes impact mortality and morbidity differently","authors":"Carlos F. Gould, Sam Heft-Neal, Alexandra K. Heaney, Eran Bendavid, Christopher W. Callahan, Mathew V. Kiang, Josh Graff Zivin, Marshall Burke","doi":"10.1126/sciadv.adr3070","DOIUrl":"10.1126/sciadv.adr3070","url":null,"abstract":"<div >Increased temperature-related mortality is expected to significantly contribute to future economic damages from climate change, with declines in cold-related deaths outweighed by increases in heat-related deaths. While temperature-mortality relationships are well-documented, the effects of climate change on morbidity are less understood. Using data on emergency department (ED) visits, hospital admissions, mortality, and daily temperatures across California from 2006 to 2017, we find distinct differences in the temperature-response functions of these health outcomes, influenced by age distribution and underlying causes of morbidity and mortality. These differential responses fundamentally shape the burden of future climate change: We project that while future warming will increase ED visits, mortality will decrease due to fewer cold extremes. These results underscore the need to quantify temperature-morbidity responses to fully understand and anticipate the health impacts of climate change and suggest that local declines in mortality due to warming can mask economically meaningful increases in temperature-driven morbidity and health care utilization.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 31","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr3070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking bioturbation through time: The evolution of the marine sedimentary mixed and transition layers 随时间跟踪生物扰动：海相沉积混合层和过渡层的演化

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adu7719

Lidya G. Tarhan, Kate H. Pippenger, Alison T. Cribb, Michelle Zill, William Phelps, Mary L. Droser, David J. Bottjer, Matthew E. Clapham

{"title":"Tracking bioturbation through time: The evolution of the marine sedimentary mixed and transition layers","authors":"Lidya G. Tarhan, Kate H. Pippenger, Alison T. Cribb, Michelle Zill, William Phelps, Mary L. Droser, David J. Bottjer, Matthew E. Clapham","doi":"10.1126/sciadv.adu7719","DOIUrl":"10.1126/sciadv.adu7719","url":null,"abstract":"<div >The physical, biogeochemical, and ecological properties of the modern seafloor are extensively shaped by the activities of burrowing and sediment-mixing animals, processes collectively known as bioturbation. Bioturbation is primarily recorded by homogenized sediments of the seafloor mixed layer and the underlying transition layer of discrete burrows. Although these two zones can be readily measured today, there has been limited understanding of how the mixed and transition layers evolved over the Phanerozoic since animals first began to extensively colonize the seafloor. Here, we provide a record for the depths of the sedimentary mixed and transition layers through the Phanerozoic. We find that although deepening of the sediment mixed layer spanned hundreds of millions of years, a deep transition layer was established as early as the Cambrian and did not further deepen until the Mesozoic—trajectories reflecting evolutionary radiations, changes in nutrient cycling, and alleviation of oxygen stress.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 31","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu7719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose metformin requires brain Rap1 for its antidiabetic action 低剂量二甲双胍的降糖作用需要脑Rap1

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adu3700

Hsiao-Yun Lin, Weisheng Lu, Yanlin He, Yukiko Fu, Kentaro Kaneko, Peimeng Huang, Ana B. De la Puente-Gomez, Chunmei Wang, Yongjie Yang, Feng Li, Yong Xu, Makoto Fukuda

{"title":"Low-dose metformin requires brain Rap1 for its antidiabetic action","authors":"Hsiao-Yun Lin, Weisheng Lu, Yanlin He, Yukiko Fu, Kentaro Kaneko, Peimeng Huang, Ana B. De la Puente-Gomez, Chunmei Wang, Yongjie Yang, Feng Li, Yong Xu, Makoto Fukuda","doi":"10.1126/sciadv.adu3700","DOIUrl":"10.1126/sciadv.adu3700","url":null,"abstract":"<div >Metformin is the most commonly prescribed antidiabetes drug, yet its precise mechanism of action remains controversial. Previous studies have suggested that metformin acts peripherally by reducing hepatic glucose output and altering gut functions. Here, we report a neural mechanism via the small guanosine triphosphatase Ras-related protein 1 (Rap1). Mice with forebrain-specific <i>Rap1</i> knockout exhibited resistance to the antidiabetic effects of low-dose metformin while remaining sensitive to other antidiabetic agents. Centrally administered metformin inhibited brain Rap1 and reduced hyperglycemia. Conversely, forced activation of brain Rap1 increased glycemia and abolished the glycemic effect of metformin. Metformin activated a specific subset of neurons in the ventromedial hypothalamic nucleus (VMH) that requires Rap1. Both loss-of-function and gain-of-function studies suggest that VMH Rap1 is indispensable for the antidiabetic effects of metformin. These findings highlight the VMH Rap1 pathway as a critical mediator of metformin action.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 31","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu3700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood nutritional stress and later-life health outcomes in medieval England: Evidence from incremental dentine analysis 中世纪英格兰儿童营养压力和晚年健康结果：来自增量牙质分析的证据

IF 12.5 1区综合性期刊

Science Advances Pub Date : 2025-07-30 DOI: 10.1126/sciadv.adw7076

Sharon N. DeWitte, Julia Beaumont, Brittany S. Walter, Jacqueline R. Towers, Emily J. Brennan

{"title":"Childhood nutritional stress and later-life health outcomes in medieval England: Evidence from incremental dentine analysis","authors":"Sharon N. DeWitte, Julia Beaumont, Brittany S. Walter, Jacqueline R. Towers, Emily J. Brennan","doi":"10.1126/sciadv.adw7076","DOIUrl":"10.1126/sciadv.adw7076","url":null,"abstract":"<div >Numerous studies have revealed links between prenatal/early-life stress and elevated morbidity and risks of mortality later in life. Given the number of subsistence crises in medieval England, this study uses stable isotopic, demographic, and paleopathological data from human skeletal remains (<i>n</i> = 275) to assess associations between early-life nutritional stress and health outcomes before, during, and after the Black Death in London and rural Lincolnshire approximately 1000 to 1540 CE. Our results suggest that survivors of early-life nutritional stress were resilient with respect to causes of death in childhood, adolescence, and early adulthood. Ultimately, however, early-life nutritional stress was associated with the presence of skeletal biomarkers of stress and elevated mortality in middle and late adulthood in the medieval period, consistent with models from developmental biology. We find that the prevalence of nutritional stress increased before the Black Death and decreased afterward. Understanding the long-term consequences of early-life nutritional stress can offer insights on the health trajectories of historical populations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 31","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0