Science Advances最新文献_第3页

Disentangling the intertwined orders in a magnetic kagome metal 解缠在一起的顺序在磁性kagome金属

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adt2195

Ji Seop Oh, Ananya Biswas, Mason L. Klemm, Hengxin Tan, Yaofeng Xie, Bin Gao, Makoto Hashimoto, Donghui Lu, Binghai Yan, Pengcheng Dai, Robert J. Birgeneau, Ming Yi

{"title":"Disentangling the intertwined orders in a magnetic kagome metal","authors":"Ji Seop Oh, Ananya Biswas, Mason L. Klemm, Hengxin Tan, Yaofeng Xie, Bin Gao, Makoto Hashimoto, Donghui Lu, Binghai Yan, Pengcheng Dai, Robert J. Birgeneau, Ming Yi","doi":"10.1126/sciadv.adt2195","DOIUrl":"10.1126/sciadv.adt2195","url":null,"abstract":"<div >Intertwined orders appear when multiple orders are strongly interacting, and kagome metals have emerged as new platforms to explore exotic phases. FeGe has been found to develop a charge density wave (CDW) order within magnetic phase, suggesting an intricate interplay of the lattice, charge, and spin degrees of freedom. Recently, postgrowth annealing has been proposed to tune the CDW order from long-range to complete suppression, offering a tuning knob for the CDW order. Here, by comparing the electronic structures of FeGe subjected to different annealing conditions and distinct CDW properties, we report spectral evolution associated with the lattice and spin degrees of freedom. We find band evolution linked to a spin density wave (SDW) order present in both samples with and without CDW order, and another evolution connected to the lattice distortions that onset with the long-range CDW order and revert with the SDW order. Our results reveal a rare competitive cooperation of the lattice, spin, and charge in FeGe.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt2195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delving into LLM-assisted writing in biomedical publications through excess vocabulary 通过过量的词汇钻研法学硕士辅助的生物医学出版物写作

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adt3813

Dmitry Kobak, Rita González-Márquez, Emőke-Ágnes Horvát, Jan Lause

引用次数: 0

Reinvented sodium anode by creating a metal-bulk storage matrix with an expanded 3D plating/stripping mechanism 通过创建具有扩展3D电镀/剥离机制的金属散装存储矩阵，重新发明了钠阳极

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adw5701

Chutao Wang, Kun Wang, Hongbin Ni, Congcong Du, Xiaoting Yin, Jingmin Fan, Ruming Yuan, Yuxin Tang, Jiawei Yan, Mingsen Zheng, Quanfeng Dong

{"title":"Reinvented sodium anode by creating a metal-bulk storage matrix with an expanded 3D plating/stripping mechanism","authors":"Chutao Wang, Kun Wang, Hongbin Ni, Congcong Du, Xiaoting Yin, Jingmin Fan, Ruming Yuan, Yuxin Tang, Jiawei Yan, Mingsen Zheng, Quanfeng Dong","doi":"10.1126/sciadv.adw5701","DOIUrl":"10.1126/sciadv.adw5701","url":null,"abstract":"<div >Direct metal anodes are plating/stripping processes without a supporting framework and bulk ion conductivity; they are the electrodes susceptible to collapse and limiting the electrochemical reaction to the two-dimensional surface. The focus of this era is mostly on building a solid electrolyte interface (SEI). However, simply building protective layers cannot address essential issues; a thorough transformation of the metal electrode bulk is critical. We propose a reconstructed sodium metal anode (RSMA) by implanting an activatable ion-conductive network to the bulk. NaPF<sub>6</sub> will be activated with an electrolyte to conduct ions and form an anion-derived SEI. Conductive polymers become the supporting skeleton; thus, the RSMA has a metal-bulk storage matrix and an expanded three-dimensional plating/stripping mechanism and permits the homogeneous deposition/dissolution of Na<sup>+</sup> in high dimensions. Last, RSMA symmetric cells were stably cycled for 2700 hours and achieved a 100% depth of discharge. RSMA||PB cells can achieve 10-coulomb cycling and a proof-of-concept pouch cell energy density of 367 watt-hours per kilogram.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw5701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional disparities in US media coverage of archaeology research 美国媒体对考古研究报道的地区差异

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adt5435

Bridget Alex, Jenny Ji, Rowan Flad

引用次数: 0

Optical tweeze-sectioning microscopy for 3D imaging and manipulation of suspended cells 用于悬浮细胞三维成像和操作的光学镊子切片显微镜

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adx3900

Xing Li, Dan Dan, Siarhei Zavatski, Wenyu Gao, Qiang Zhang, Yuan Zhou, Jia Qian, Yanlong Yang, Xianghua Yu, Shaohui Yan, Xiaohao Xu, Olivier J. F. Martin, Baoli Yao

{"title":"Optical tweeze-sectioning microscopy for 3D imaging and manipulation of suspended cells","authors":"Xing Li, Dan Dan, Siarhei Zavatski, Wenyu Gao, Qiang Zhang, Yuan Zhou, Jia Qian, Yanlong Yang, Xianghua Yu, Shaohui Yan, Xiaohao Xu, Olivier J. F. Martin, Baoli Yao","doi":"10.1126/sciadv.adx3900","DOIUrl":"10.1126/sciadv.adx3900","url":null,"abstract":"<div >Optical manipulation and detection of biological particulates are crucial procedures in biophotonics. Optical sectioning (OS) opens the avenue to three-dimensional (3D) microscopy, but nonoptical approaches, including sample adhesion and mechanical scanning, have always been required in this technique, rendering it impossible to image suspended cells. Here, we develop optical tweeze-sectioning microscopy by coupling structured illumination microscopy (SIM) with holographic optical tweezers (HOTs). By sculpting light in HOTs, we demonstrate that the position fluctuations of suspended yeast cells can be optically squeezed to tens of nanometers, which is sufficient for the implementation of OS with SIM. Sample scanning is achieved through optical delivery of the cells, instead of translation stages as in the conventional way. Our work presents an all-optical solution for OS, broadening its application to nonadherent, suspended cells. It further furnishes the original technique that enables both SIM-based 3D imaging and optical manipulation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx3900","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses FAF2是过氧化物酶体稳态和饱和脂质反应的双功能调节剂

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adu9104

Choah Kim, Katlyn R. Gabriel, Dylan Boone, Matthew R. Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B. Pablo, Anna Greka

{"title":"FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses","authors":"Choah Kim, Katlyn R. Gabriel, Dylan Boone, Matthew R. Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B. Pablo, Anna Greka","doi":"10.1126/sciadv.adu9104","DOIUrl":"10.1126/sciadv.adu9104","url":null,"abstract":"<div >Exposure to saturated fatty acids (SFAs), such as palmitic acid, can lead to cellular metabolic dysfunction known as lipotoxicity. Although canonical adaptive metabolic processes like lipid storage or desaturation are known cellular responses to saturated fat exposure, the link between SFA metabolism and organellar biology remains an area of active inquiry. We performed a genome-wide CRISPR knockout screen in human epithelial cells to identify modulators of SFA toxicity. The screen revealed peroxisomal proteins, especially those that affect ether lipid synthesis, as important regulators of lipotoxicity. We identified Fas-associated factor family member 2 (FAF2) as a critical bifunctional coregulator of peroxisomal and fatty acid biology. We further demonstrated the requirement of the ubiquitin-regulatory X (UBX) and UAS thioredoxin-like domains of FAF2 for peroxisomal protein abundance and SFA-induced cellular stress. Our work highlights the role of FAF2 in regulating peroxisomal abundance and function and the peroxisome as a key organelle in the cellular response to SFAs.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu9104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ evidence for serpentinization within the Máaz formation, Jezero crater, Mars 火星耶泽洛陨石坑Máaz地层内蛇纹石化的现场证据

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adr8793

Nicholas J. Tosca, Michael M. Tice, Joel A. Hurowitz, David A. K. Pedersen, Jesper Henneke, Lucia Mandon, Francis M. McCubbin, Oliver Ross, Po-Yen Tung, Richard J. Harrison, An Li, Mariek E. Schmidt, Tanya V. Kizovski, Yang Liu, Lisa Mayhew, Michael W. M. Jones, Josh Labrie, Scott Davidoff, Abigail C. Allwood, Olivier Beyssac, Adrian Brown, Morgan Cable, Jade Comellas, Benton C. Clark, Adrian E. Galvin, Briony Horgan, Christopher M. Heirwegh, Peter Nemere, Brendan J. Orenstein, Cathy Quantin-Nataf, Clément Royer, Allan Treiman, Lawrence A. Wade, Roger Wiens, Austin P. Wright

{"title":"In situ evidence for serpentinization within the Máaz formation, Jezero crater, Mars","authors":"Nicholas J. Tosca, Michael M. Tice, Joel A. Hurowitz, David A. K. Pedersen, Jesper Henneke, Lucia Mandon, Francis M. McCubbin, Oliver Ross, Po-Yen Tung, Richard J. Harrison, An Li, Mariek E. Schmidt, Tanya V. Kizovski, Yang Liu, Lisa Mayhew, Michael W. M. Jones, Josh Labrie, Scott Davidoff, Abigail C. Allwood, Olivier Beyssac, Adrian Brown, Morgan Cable, Jade Comellas, Benton C. Clark, Adrian E. Galvin, Briony Horgan, Christopher M. Heirwegh, Peter Nemere, Brendan J. Orenstein, Cathy Quantin-Nataf, Clément Royer, Allan Treiman, Lawrence A. Wade, Roger Wiens, Austin P. Wright","doi":"10.1126/sciadv.adr8793","DOIUrl":"10.1126/sciadv.adr8793","url":null,"abstract":"<div >As both a source of atmospheric H<sub>2</sub> and a sink for liquid water, the serpentinization of olivine-bearing rocks is widely thought to have influenced the long-term evolution of the early martian atmosphere and hydrosphere. However, the mechanisms, timing, and global importance of this process are unconstrained, in part because the remnants of ancient serpentinizing systems have not been examined in situ. New geochemical and mineralogical data from multiple instruments aboard the Mars 2020 Perseverance rover record serpentinization and associated H<sub>2</sub> production in ancient igneous rocks of the Máaz formation, exposed on the Jezero crater floor. These data, combined with petrogenetic constraints, indicate that serpentinization may have been driven by devolatilization of magmatic H<sub>2</sub>O, highlighting a potential link between H<sub>2</sub> production and the style and tempo of magmatism within the ancient martian crust.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr8793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Universal dimensions of visual representation 视觉表现的普遍维度

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adw7697

Zirui Chen, Michael F. Bonner

{"title":"Universal dimensions of visual representation","authors":"Zirui Chen, Michael F. Bonner","doi":"10.1126/sciadv.adw7697","DOIUrl":"10.1126/sciadv.adw7697","url":null,"abstract":"<div >Do visual neural networks learn brain-aligned representations because they share architectural constraints and task objectives with biological vision or because they share universal features of natural image processing? We characterized the universality of hundreds of thousands of representational dimensions from networks with different architectures, tasks, and training data. We found that diverse networks learn to represent natural images using a shared set of latent dimensions, despite having highly distinct designs. Next, by comparing these networks with human brain representations measured with functional magnetic resonance imaging, we found that the most brain-aligned representations in neural networks are those that are universal and independent of a network’s specific characteristics. Each network can be reduced to fewer than 10 of its most universal dimensions with little impact on its representational similarity to the brain. These results suggest that the underlying similarities between artificial and biological vision are primarily governed by a core set of universal representations that are convergently learned by diverse systems.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell analysis of the decidua unveils the mechanism of anti-inflammatory exosomes for chorioamnionitis in nonhuman primates 蜕膜的单细胞分析揭示了非人类灵长类动物绒毛膜羊膜炎的抗炎外泌体机制

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adp0467

Seung Hyun Jang, Hojun Choi, Eun Mi Lee, Seung-Bin Yoon, Hye-Jung Kim, Cheolhyoung Park, Jae Kyung Won, Seung Han Shin, Ji-Su Kim, Chan-Wook Park, Heon Yung Gee, Chulhee Choi

{"title":"Single-cell analysis of the decidua unveils the mechanism of anti-inflammatory exosomes for chorioamnionitis in nonhuman primates","authors":"Seung Hyun Jang, Hojun Choi, Eun Mi Lee, Seung-Bin Yoon, Hye-Jung Kim, Cheolhyoung Park, Jae Kyung Won, Seung Han Shin, Ji-Su Kim, Chan-Wook Park, Heon Yung Gee, Chulhee Choi","doi":"10.1126/sciadv.adp0467","DOIUrl":"10.1126/sciadv.adp0467","url":null,"abstract":"<div >The effectiveness of exosomes engineered to carry a dominantly active variant of inhibitor α of nuclear factor κB (NF-κB) (IκBα), super-repressor IκB (srIκB), that inhibits the expression of NF-κB in various animal models of inflammatory diseases has been demonstrated. In this study, we used a lipopolysaccharide (LPS)–induced chorioamnionitis model in pregnant nonhuman primates to explore the therapeutic potential and mode of action of srIκB-loaded exosomes (Exo-srIκBs). Intraamniotic injection of LPS induced infiltration of BCL2A1-positive neutrophils and CD68-positive macrophages in the extraplacental membranes, causing fetal lung injury. Conversely, administration of Exo-srIκB via intraamniotic and intravenous routes (6.9 × 10<sup>10</sup> and 4 × 10<sup>11</sup> particle numbers, respectively) ameliorated these effects. Single-cell RNA sequencing of the decidua and bulk RNA sequencing of the choriodecidua highlighted that Exo-srIκB treatment mitigated LPS-induced inflammatory pathways, particularly in macrophages, leading to a cascade effect on neutrophils through NF-κB signaling inhibition. These findings underscore the potential of Exo-srIκB as a therapeutic strategy for chorioamnionitis.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp0467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2 ppe71 -esx - esxy - ppe38位点的缺失驱动结核分枝杆菌谱系的适应性转录反应和高毒力2

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2025-07-02 DOI: 10.1126/sciadv.adw5194

Benjamin Koleske, Courtney Schill, Saranathan Rajagopalan, Somnath Shee, Yazmin B. Martinez-Martinez, Manish Gupta, Jessica Shen, William R. Jacobs Jr., William R. Bishai

{"title":"Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2","authors":"Benjamin Koleske, Courtney Schill, Saranathan Rajagopalan, Somnath Shee, Yazmin B. Martinez-Martinez, Manish Gupta, Jessica Shen, William R. Jacobs Jr., William R. Bishai","doi":"10.1126/sciadv.adw5194","DOIUrl":"10.1126/sciadv.adw5194","url":null,"abstract":"<div ><i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) is remarkable for its immense global disease burden and low mutation rate. Despite strong selective pressure, <i>M.tb</i> shows frequent deletions at the <i>PPE71</i>–<i>38</i> locus, most notably in hypervirulent L2 Beijing strains. Here, we show that loss of the <i>PPE71</i>–<i>38</i> locus causes increased stress response gene expression and increased triglyceride levels. In addition, we demonstrate that reintroduction of <i>PPE71</i> into the L2 strain HN878 suppresses the baseline elevation of these transcripts, while overexpression of <i>PPE71</i> increases the localization of PE_PGRS proteins and lipoproteins to the <i>M.tb</i> outer mycomembrane. Mouse infection confirmed the hypervirulence of the <i>PPE71</i>–<i>38</i> deletion strain and conversely showed that <i>PPE71</i> overexpression attenuates <i>M.tb</i>. Our results indicate that loss of <i>PPE71</i>–<i>38</i> is sufficient to drive an adaptive transcriptional response seen in <i>M.tb</i> L2 strains that likely contributes to the hypervirulence of this lineage.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw5194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0