Science Advances最新文献_第3页

Decoding the interplay between m6A modification and stress granule stability by live-cell imaging 通过活细胞成像解码 m 6 A 修饰与应力颗粒稳定性之间的相互作用

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-15 DOI: 10.1126/sciadv.adp5689

Qianqian Li, Jian Liu, Liping Guo, Yi Zhang, Yanwei Chen, Huijuan Liu, Hongyu Cheng, Lin Deng, Juhui Qiu, Ke Zhang, Wee Siong Sho Goh, Yingxiao Wang, Qin Peng

{"title":"Decoding the interplay between m6A modification and stress granule stability by live-cell imaging","authors":"Qianqian Li, Jian Liu, Liping Guo, Yi Zhang, Yanwei Chen, Huijuan Liu, Hongyu Cheng, Lin Deng, Juhui Qiu, Ke Zhang, Wee Siong Sho Goh, Yingxiao Wang, Qin Peng","doi":"10.1126/sciadv.adp5689","DOIUrl":"10.1126/sciadv.adp5689","url":null,"abstract":"<div ><i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A)–modified mRNAs and their cytoplasmic reader YTHDFs are colocalized with stress granules (SGs) under stress conditions, but the interplay between m<sup>6</sup>A modification and SG stability remains unclear. Here, we presented a spatiotemporal m<sup>6</sup>A imaging system (SMIS) that can monitor the m<sup>6</sup>A modification and the translation of mRNAs with high specificity and sensitivity in a single live cell. SMIS showed that m<sup>6</sup>A-modified reporter mRNAs dynamically enriched into SGs under arsenite stress and gradually partitioned into the cytosol as SG disassembled. SMIS revealed that knockdown of YTHDF2 contributed to SG disassembly, resulting in the fast redistribution of mRNAs from SGs and rapid recovery of stalled translation. The mechanism is that YTHDF2 can regulate SG stability through the interaction with G3BP1 in m<sup>6</sup>A-modified RNA-dependent manner. Our results suggest a mechanism for the interplay between m<sup>6</sup>A modification and SG through YTHDF2 regulation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp5689","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frailty or resilience? Hazard-based and cumulative phenotype approaches to discerning signals of health inequality in medieval London 虚弱还是复原力？用基于危害和累积表型的方法辨别中世纪伦敦健康不平等的信号

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adq5703

Samantha L. Yaussy, Kathryn E. Marklein, Sharon N. DeWitte, Douglas E. Crews

{"title":"Frailty or resilience? Hazard-based and cumulative phenotype approaches to discerning signals of health inequality in medieval London","authors":"Samantha L. Yaussy, Kathryn E. Marklein, Sharon N. DeWitte, Douglas E. Crews","doi":"10.1126/sciadv.adq5703","DOIUrl":"10.1126/sciadv.adq5703","url":null,"abstract":"<div >Bioarchaeology uses human skeletal remains to reconstruct varied experiences of individuals and populations in the past, including patterns of health across time periods and cultural contexts. In the past three decades, bioarchaeological studies have highlighted the concept of “frailty,” operationalizing it as increased risk of mortality or cumulative phenotypes. Using data from medieval London cemeteries, we integrate these two approaches to frailty in past populations. First, we estimate the risks of mortality and survivorship (hazard and survival analyses) associated with 10 biomarkers and use these results to construct population-specific frailty and resilience indices. Then, we apply the indices to adult individuals to explore frailty and resilience differentials between males and females in medieval London. Findings suggest that the male-female morbidity-mortality paradox observed in modern populations may not have existed in this context, which may be explained by preferential cultural buffering of men in this patriarchal, urban setting.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq5703","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme wind events responsible for an outsized role in shelf-basin exchange around the southern tip of Greenland 在格陵兰岛南端陆架-盆地交换过程中发挥巨大作用的极端风力事件

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adp9266

Arthur Coquereau, Nicholas P. Foukal, Kjetil Våge

引用次数: 0

Rubbery organic frameworks (ROFs) toward ultrapermeable CO2-selective membranes 橡胶有机框架（ROFs）用于超渗透二氧化碳选择性膜

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adq5024

Marius Sandru, Marie Prache, Thomas Macron, Lidia Căta, Mehmet Göktuğ Ahunbay, May-Britt Hägg, Guillaume Maurin, Mihail Barboiu

{"title":"Rubbery organic frameworks (ROFs) toward ultrapermeable CO2-selective membranes","authors":"Marius Sandru, Marie Prache, Thomas Macron, Lidia Căta, Mehmet Göktuğ Ahunbay, May-Britt Hägg, Guillaume Maurin, Mihail Barboiu","doi":"10.1126/sciadv.adq5024","DOIUrl":"10.1126/sciadv.adq5024","url":null,"abstract":"<div >The capture of CO<sub>2</sub> is of high interest in our society representing an essential tool to mitigate man-made climate warming. Membrane technology applied for CO<sub>2</sub> capture offers several advantages in terms of energy savings, simple operation, and easy scale-up. Glassy membranes are associated with low gas permeability that negatively affect on their industrial implementation. Oppositely, rubbery membranes offer high permeability, but their selectivity is low. Here we report rubbery organic frameworks (ROFs) combining the high permeability of soft matrices with the high sieving selectivity of molecular frameworks. The best performing membranes provide a CO<sub>2</sub>/N<sub>2</sub> selectivity up to 104 with a CO<sub>2</sub> permeability up to 1000 Barrer, representing relevant performances for industrial implementation. Water vapors have a positive effect on CO<sub>2</sub> permeability, and the CO<sub>2</sub>/N<sub>2</sub> selectivity is higher than in dry conditions, as most of CO<sub>2</sub> gas emissions are present in fully humidified gas streams. The synergetic high permeability/selectivity performances are superior to that observed with current state-of-the-art polymeric membranes.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq5024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nearly terrestrial D/H for comet 67P/Churyumov-Gerasimenko 67P/丘留莫夫-格拉西缅科彗星的近地D/H

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adp2191

Kathleen E. Mandt, Jacob Lustig-Yaeger, Adrienn Luspay-Kuti, Peter Wurz, Dennis Bodewits, Stephen A. Fuselier, Olivier Mousis, Steven M. Petrinec, Karlheinz J. Trattner

引用次数: 0

Fractional change of scattering and absorbing aerosols contributes to Northern Hemisphere Hadley circulation expansion 散射和吸收气溶胶的分数变化有助于北半球哈德利环流扩张

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adq9716

Tong Ying, Jing Li, Qiang Fu, Guanyu Liu, Lu Zhang, Yan Xia, Yongyun Hu

引用次数: 0

Experience-dependent, sexually dimorphic synaptic connectivity defined by sex-specific cadherin expression 由性别特异性粘连蛋白表达确定的经验依赖性、性别双态突触连接性

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adq9183

Chien-Po Liao, Maryam Majeed, Oliver Hobert

{"title":"Experience-dependent, sexually dimorphic synaptic connectivity defined by sex-specific cadherin expression","authors":"Chien-Po Liao, Maryam Majeed, Oliver Hobert","doi":"10.1126/sciadv.adq9183","DOIUrl":"10.1126/sciadv.adq9183","url":null,"abstract":"<div >Early-life experience influences subsequent maturation and function of the adult brain, sometimes even in a sex-specific manner, but underlying molecular mechanisms are poorly understood. We describe here how juvenile experience defines sexually dimorphic synaptic connectivity in the adult <i>Caenorhabditis elegans</i> nervous system. Starvation of juvenile males disrupts serotonin-dependent activation of the CREB transcription factor in a nociceptive sensory neuron, PHB. CREB acts through a cascade of transcription factors to control expression of an atypical cadherin protein, FMI-1/Flamingo/CELSR. During postembryonic development, FMI-1 promotes and maintains synaptic connectivity of PHB to a command interneuron, AVA, in both sexes, but a serotonin-dependent transcriptional regulatory cassette antagonizes FMI-1 expression in males, thereby establishing sexually dimorphic connectivity between PHB and AVA. A critical regulatory node is the CREB-target LIN-29, a Zn finger transcription factor that integrates four layers of information: sexual specificity, past experience, time and cell-type specificity. Our findings provide the mechanistic details of how an early juvenile experience defines sexually dimorphic synaptic connectivity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq9183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unambiguous discrimination of general quantum operations 对一般量子操作的明确判别

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adq2529

Weizhou Cai, Jing-Ning Zhang, Ziyue Hua, Weiting Wang, Xiaoxuan Pan, Xinyu Liu, Yuwei Ma, Ling Hu, Xianghao Mu, Haiyan Wang, Yipu Song, Chang-Ling Zou, Luyan Sun

{"title":"Unambiguous discrimination of general quantum operations","authors":"Weizhou Cai, Jing-Ning Zhang, Ziyue Hua, Weiting Wang, Xiaoxuan Pan, Xinyu Liu, Yuwei Ma, Ling Hu, Xianghao Mu, Haiyan Wang, Yipu Song, Chang-Ling Zou, Luyan Sun","doi":"10.1126/sciadv.adq2529","DOIUrl":"10.1126/sciadv.adq2529","url":null,"abstract":"<div >The discrimination of quantum operations has long been an intriguing challenge, with theoretical research notably advancing our understanding of the quantum features in discriminating quantum objects. This challenge is closely related to the discrimination of quantum states, and proof-of-principle demonstrations of the latter have already been realized using optical photons. However, the experimental demonstration of discriminating general quantum operations, including both unitary and nonunitary operations, has remained elusive. In general quantum systems, especially those with high dimensions, the preparation of arbitrary quantum states and the implementation of arbitrary quantum operations and generalized measurements are nontrivial tasks. Here, we experimentally demonstrate the optimal unambiguous discrimination of up to six displacement operators and the unambiguous discrimination of nonunitary quantum operations. Our results demonstrate powerful tools for experimental research in quantum information processing and are expected to stimulate a wide range of valuable applications in the field of quantum sensing.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq2529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Channel width modulates the permeability of DNA origami–based nuclear pore mimics 通道宽度调节基于 DNA 折纸的核孔模拟物的通透性

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adq8773

Qingzhou Feng, Martin Saladin, Chunxiang Wu, Eason Cao, Wei Zheng, Amy Zhang, Pushpanjali Bhardwaj, Xia Li, Qi Shen, Larisa E. Kapinos, Toshiya Kozai, Malaiyalam Mariappan, C. Patrick Lusk, Yong Xiong, Roderick Y. H. Lim, Chenxiang Lin

{"title":"Channel width modulates the permeability of DNA origami–based nuclear pore mimics","authors":"Qingzhou Feng, Martin Saladin, Chunxiang Wu, Eason Cao, Wei Zheng, Amy Zhang, Pushpanjali Bhardwaj, Xia Li, Qi Shen, Larisa E. Kapinos, Toshiya Kozai, Malaiyalam Mariappan, C. Patrick Lusk, Yong Xiong, Roderick Y. H. Lim, Chenxiang Lin","doi":"10.1126/sciadv.adq8773","DOIUrl":"10.1126/sciadv.adq8773","url":null,"abstract":"<div >Nucleoporins (nups) in the nuclear pore complex (NPC) form a selective barrier that suppresses the diffusion of most macromolecules while enabling rapid transport of nuclear transport receptor (NTR)–bound cargos. Recent studies have shown that the NPC may dilate and constrict, but how altering the NPC diameter affects its selective barrier properties remains unclear. Here, we build DNA nanopores with programmable diameters and nup arrangements to model the constricted and dilated NPCs. We find that Nup62 proteins form a dynamic cross-channel barrier impermeable to hepatitis B virus (HBV) capsids when grafted inside 60-nm-wide nanopores but not in 79-nm pores, where Nup62 cluster locally. Furthermore, importin-β1 substantially changes the dynamics of Nup62 assemblies and facilitates the passage of HBV capsids through the 60-nm NPC mimics containing Nup62 and Nup153. Our study shows that transport channel width is critical to the permeability of nup barriers and underscores NTRs’ role in dynamically remodeling nup assemblies and mediating the nuclear entry of viruses.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq8773","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ediacaran origin and Ediacaran-Cambrian diversification of Metazoa 埃迪卡拉纪起源和埃迪卡拉-寒武纪元古宙的多样化

IF 11.7 1区综合性期刊

Science Advances Pub Date : 2024-11-13 DOI: 10.1126/sciadv.adp7161

Emily Carlisle, Zongjun Yin, Davide Pisani, Philip C. J. Donoghue

{"title":"Ediacaran origin and Ediacaran-Cambrian diversification of Metazoa","authors":"Emily Carlisle, Zongjun Yin, Davide Pisani, Philip C. J. Donoghue","doi":"10.1126/sciadv.adp7161","DOIUrl":"10.1126/sciadv.adp7161","url":null,"abstract":"<div >The timescale of animal diversification has been a focus of debate over how evolutionary history should be calibrated to geologic time. Molecular clock analyses have invariably estimated a Cryogenian or Tonian origin of animals while unequivocal animal fossils first occur in the Ediacaran. However, redating of key Ediacaran biotas and the discovery of several Ediacaran crown-Metazoa prompt recalibration of molecular clock analyses. We present revised fossil calibrations and use them in molecular clock analyses estimating the timescale of metazoan evolutionary history. Integrating across uncertainties including phylogenetic relationships, clock model, and calibration strategy, we estimate Metazoa to have originated in the early Ediacaran, Eumetazoa in the middle Ediacaran, and Bilateria in the upper Ediacaran, with many crown-phyla originating across the Ediacaran-Cambrian interval or elsewise fully within the Cambrian. These results are in much closer accord with the fossil record, coinciding with marine oxygenation, but they reject a literal reading of the fossil record.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adp7161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0