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Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription Hippo信号通过调控YAP和TEAD的核行为和DNA结合时间来控制转录
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adw4974
Benjamin Kroeger, Samuel A. Manning, Varshini Mohan, Jieqiong Lou, Guizhi Sun, Sara Lamont, Alex J. McCann, Mathias Francois, Jose M. Polo, Elizabeth Hinde, Kieran F. Harvey
{"title":"Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription","authors":"Benjamin Kroeger,&nbsp;Samuel A. Manning,&nbsp;Varshini Mohan,&nbsp;Jieqiong Lou,&nbsp;Guizhi Sun,&nbsp;Sara Lamont,&nbsp;Alex J. McCann,&nbsp;Mathias Francois,&nbsp;Jose M. Polo,&nbsp;Elizabeth Hinde,&nbsp;Kieran F. Harvey","doi":"10.1126/sciadv.adw4974","DOIUrl":"10.1126/sciadv.adw4974","url":null,"abstract":"<div >Over the past two decades, genetic and proteomic screens have identified the Hippo pathway as a complex signaling network that controls tissue growth and human cancer. Despite these advances, our understanding of how Hippo signaling regulates transcription is less clear. To address this, we used live microscopy to study the nuclear behavior of the major Hippo pathway transcription effectors, YAP and TEADs. We reveal that TEADs are a major determinant of YAP DNA binding and nuclear mobility, while YAP minorly influences TEADs. YAP and TEAD1 associate with DNA for longer periods in cells with intrinsically low Hippo pathway activity and upon acute Hippo pathway perturbation. TEAD1 binds the genome on a broad range of timescales, and this is extended substantially in nuclear condensates. Last, a cancer-associated YAP fusion protein exhibits substantially different biophysical behavior than either YAP or TEAD1. Thus, we reveal that Hippo signaling regulates transcription, in part, by influencing the DNA binding times of YAP and TEADs.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw4974","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unprecedented continental drying, shrinking freshwater availability, and increasing land contributions to sea level rise 前所未有的大陆干旱,淡水资源的减少,以及不断增加的陆地对海平面上升的贡献
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adx0298
Hrishikesh A. Chandanpurkar, James S. Famiglietti, Kaushik Gopalan, David N. Wiese, Yoshihide Wada, Kaoru Kakinuma, John T. Reager, Fan Zhang
{"title":"Unprecedented continental drying, shrinking freshwater availability, and increasing land contributions to sea level rise","authors":"Hrishikesh A. Chandanpurkar,&nbsp;James S. Famiglietti,&nbsp;Kaushik Gopalan,&nbsp;David N. Wiese,&nbsp;Yoshihide Wada,&nbsp;Kaoru Kakinuma,&nbsp;John T. Reager,&nbsp;Fan Zhang","doi":"10.1126/sciadv.adx0298","DOIUrl":"10.1126/sciadv.adx0298","url":null,"abstract":"<div >Changes in terrestrial water storage (TWS) are a critical indicator of freshwater availability. We use NASA GRACE/GRACE-FO data to show that the continents have undergone unprecedented TWS loss since 2002. Areas experiencing drying increased by twice the size of California annually, creating “mega-drying” regions across the Northern Hemisphere. While most of the world’s dry/wet areas continue to get drier/wetter, dry areas are now drying faster than wet areas are wetting. Changes in TWS are driven by high-latitude water losses, intense Central American/European droughts, and groundwater depletion, which accounts for 68% of TWS loss over non-glaciated continental regions. “Continental drying” is having profound global impacts. Since 2002, 75% of the population lives in 101 countries that have been losing freshwater water. Furthermore, the continents now contribute more freshwater to sea level rise than the ice sheets, and drying regions now contribute more than land glaciers and ice caps. Urgent action is required to prepare for the major impacts of results presented.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx0298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A general leaving group assisted strategy for synthesis of pentafluorosulfanyl allylic compounds 合成五氟磺胺基烯丙基化合物的一般离去基辅助策略
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adw8408
Hui-Yi Yang, Hai-Bao Du, Yong-Ping Bai, Ya-Hui Ding, Yi-Fan Ma, Gang Wu, Ning Zhang, Nathaniel K. Szymczak, Shuo Guo
{"title":"A general leaving group assisted strategy for synthesis of pentafluorosulfanyl allylic compounds","authors":"Hui-Yi Yang,&nbsp;Hai-Bao Du,&nbsp;Yong-Ping Bai,&nbsp;Ya-Hui Ding,&nbsp;Yi-Fan Ma,&nbsp;Gang Wu,&nbsp;Ning Zhang,&nbsp;Nathaniel K. Szymczak,&nbsp;Shuo Guo","doi":"10.1126/sciadv.adw8408","DOIUrl":"10.1126/sciadv.adw8408","url":null,"abstract":"<div >Fluorine-containing allyl compounds are prevalent in drugs and bioactive molecules. Here, we report a straightforward and efficient radical pentafluorosulfanylation of allyl sulfones using sulfur chloride pentafluoride (SF<sub>5</sub>Cl) to synthesize structurally diverse pentafluorosulfanyl allylic compounds. This transformation exhibits excellent functional group tolerance and achieves an impressive isolated yield of up to 98% in just 1 minute under ultraviolet light. Mechanistic studies suggest that the sulfonyl group acts as a free radical leaving group, with the capability of abstracting the chlorine atom from SF<sub>5</sub>Cl. This radical chain propagation pathway facilitates the rapid regeneration of the sulfur pentafluoride radical, resulting in a notably high quantum yield. Moreover, this light-driven radical pentafluorosulfanylation simplifies the synthetic pathway to modify complex and bioactive molecules. In addition, the drug-modified pentafluorosulfanyl compounds exhibited promising effects in inhibiting cancer cell proliferation, both in vitro and in vivo. Therefore, this protocol provides a practical synthetic route to radical pentafluorosulfanylation, highlighting its potential in drug discovery.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw8408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA damage response pathway regulates Nrf2 in response to oxidative stress DNA损伤反应通路调控Nrf2对氧化应激的响应
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adu9555
Xiao-You Jiang, Qi-Qiang Guo, Shan-Shan Wang, Ran Guo, Yu Zou, Jing-Wei Liu, Yan-Ling Feng, Yang Guo, Yu-Han Li, Xi-Yan Liu, Xin-Yue Zhang, Shuang Hao, Xiao-Xu Wu, Meng-Han Li, Ao Liu, Chun-Lu Li, Wen-Dong Guo, Hong-De Xu, Xiao-Yu Song, Toren Finkel, Liu Cao
{"title":"DNA damage response pathway regulates Nrf2 in response to oxidative stress","authors":"Xiao-You Jiang,&nbsp;Qi-Qiang Guo,&nbsp;Shan-Shan Wang,&nbsp;Ran Guo,&nbsp;Yu Zou,&nbsp;Jing-Wei Liu,&nbsp;Yan-Ling Feng,&nbsp;Yang Guo,&nbsp;Yu-Han Li,&nbsp;Xi-Yan Liu,&nbsp;Xin-Yue Zhang,&nbsp;Shuang Hao,&nbsp;Xiao-Xu Wu,&nbsp;Meng-Han Li,&nbsp;Ao Liu,&nbsp;Chun-Lu Li,&nbsp;Wen-Dong Guo,&nbsp;Hong-De Xu,&nbsp;Xiao-Yu Song,&nbsp;Toren Finkel,&nbsp;Liu Cao","doi":"10.1126/sciadv.adu9555","DOIUrl":"10.1126/sciadv.adu9555","url":null,"abstract":"<div >Nrf2 acts as a transcriptional master regulator to orchestrate antioxidant responses and maintain redox balance. However, the cellular pathway for translating oxidative stress signals into Nrf2-dependent antioxidant responses remain incompletely understood. Here, we show that reactive oxygen species (ROS) function as signaling molecules in modulating Nrf2’s stability and transcriptional activity by activating the DNA damage response (DDR) signaling pathway. When activated, CHK2 phosphorylates the autophagy adaptor protein p62 at serine-349, promoting its interaction with Keap1 and disrupting the Keap1-Nrf2 interaction, thereby inhibiting Nrf2 ubiquitination–dependent degradation. In addition, CHK2 directly phosphorylates Nrf2 at serine-566/serine-577, enhancing its transcriptional activity and antioxidant capacity. Consistent with these effects, <i>Chk2</i><sup>−/−</sup> mice show impaired expression of Nrf2 and its downstream antioxidant target genes, along with more severe renal tissue damage in an ROS-dependent model of renal ischemia/reperfusion injury. Our study reveals a direct mechanism linking the DDR signaling pathway to ROS-triggered Nrf2-dependent antioxidant responses, providing critical insight into cellular protection against oxidative stress–induced damage.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu9555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonchromatin regulatory functions of the histone variant H2A.B in SWI/SNF genomic deposition 组蛋白变体H2A的非染色质调控功能。B在SWI/SNF基因组沉积
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adx1568
Xuanzhao Jiang, Jiayu Wen, Mary L. Nelson, Yasmin Dijkwel, Bradley Cairns, Uta-Maria Bauer, Gene Hart-Smith, Tatiana A. Soboleva, David J. Tremethick
{"title":"Nonchromatin regulatory functions of the histone variant H2A.B in SWI/SNF genomic deposition","authors":"Xuanzhao Jiang,&nbsp;Jiayu Wen,&nbsp;Mary L. Nelson,&nbsp;Yasmin Dijkwel,&nbsp;Bradley Cairns,&nbsp;Uta-Maria Bauer,&nbsp;Gene Hart-Smith,&nbsp;Tatiana A. Soboleva,&nbsp;David J. Tremethick","doi":"10.1126/sciadv.adx1568","DOIUrl":"10.1126/sciadv.adx1568","url":null,"abstract":"<div >The replacement of canonical histones with their variant forms enables the dynamic and context-dependent regulation of the mammalian genome. Histone variants also play key roles in various pathological processes including malignancies. Among these, the aberrant expression of the testis-specific histone variant H2A.B contributes to the pathogenesis of Hodgkin lymphoma. The multifunctionality of histone variants is regulated by their posttranslational modifications (PTMs). However, the PTMs of H2A.B and their functional implications are unknown. Here, we demonstrate that the Amino terminus of H2A.B serves as a central hub for a diverse range of gene regulatory protein-protein interactions, orchestrated by phosphorylation and arginine methylation. This includes a mechanism whereby non–chromatin-bound H2A.B associates with SWI/SNF, which limits its access to the genome. Last, we identify phosphorylated H2A.B as a previously uncharacterized marker of active RNA polymerase II transcription start sites. These findings elucidate a central role for H2A.B in genome regulation and highlight the importance of its PTMs in modulating its multifunctional roles.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx1568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3 基因工程模拟软骨细胞纳米平台通过阻断IL-1β和恢复sirtuin-3来减轻骨关节炎
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adv4238
Caifeng Deng, Liukang Yu, Xuan Zhao, Yuxiao Chen, Jiabin Mei, Jie Wei, Xiaoyuan Chen, Guanghua Lei, Chao Zeng
{"title":"Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3","authors":"Caifeng Deng,&nbsp;Liukang Yu,&nbsp;Xuan Zhao,&nbsp;Yuxiao Chen,&nbsp;Jiabin Mei,&nbsp;Jie Wei,&nbsp;Xiaoyuan Chen,&nbsp;Guanghua Lei,&nbsp;Chao Zeng","doi":"10.1126/sciadv.adv4238","DOIUrl":"10.1126/sciadv.adv4238","url":null,"abstract":"<div >Osteoarthritis (OA) is a multifactorial disease characterized by joint inflammation and cartilage degeneration, with no disease-modifying drugs available. The vicious cycle between the inflammatory microenvironment (inflamed soil) and dysfunctional chondrocytes (degeneration-related seeds) drives the chronic progressive deterioration of OA. Here, we report a genetically engineered chondrocyte-mimetic nanoplatform (termed HKL-GECM@MPNPs) comprising a honokiol (HKL)–loaded mitochondrion-targeting nanoparticle core coated with an interleukin-1 receptor type 2 (IL-1R2)–overexpressing chondrocyte membrane. HKL-GECM@MPNPs fuse with OA chondrocytes, transferring IL-1R2 onto the plasma membrane and reprogramming the inflamed microenvironment through IL-1β blockade. Mitochondrion-targeting cores then directly deliver HKL to restore mitochondrial sirtuin-3 in OA chondrocytes, reprogramming the cells’ pathological phenotype. Intra-articular injection of HKL-GECM@MPNPs in OA mice reduces inflammation, alleviates joint pain, and mitigates cartilage damage through a synergistic effect. Moreover, HKL-GECM@MPNPs effectively reverse cartilage degeneration in human OA cartilage explants. This approach highlights the potential of HKL-GECM@MPNPs to combine IL-1β blockade and mitochondrial sirtuin-3 restoration as a promising strategy for OA treatment.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv4238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Para-(3-phenylpropiolamido)phenyl (PPAP) glycosides: Harnessing ipso-cyclization–driven glycosylation for strategic flexibility 对(3-苯基丙酰胺)苯基(PPAP)糖苷:利用ipso环化驱动的糖基化策略灵活性
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.ady4274
Meifang Yang, Yanli Qiu, Yan Tan, Li Song, Xi Xiang, Yitian Zhao, Xing Zheng, Xiangwei Zheng, Weiliang Gu, Guoqiang Lin, Houchao Tao
{"title":"Para-(3-phenylpropiolamido)phenyl (PPAP) glycosides: Harnessing ipso-cyclization–driven glycosylation for strategic flexibility","authors":"Meifang Yang,&nbsp;Yanli Qiu,&nbsp;Yan Tan,&nbsp;Li Song,&nbsp;Xi Xiang,&nbsp;Yitian Zhao,&nbsp;Xing Zheng,&nbsp;Xiangwei Zheng,&nbsp;Weiliang Gu,&nbsp;Guoqiang Lin,&nbsp;Houchao Tao","doi":"10.1126/sciadv.ady4274","DOIUrl":"10.1126/sciadv.ady4274","url":null,"abstract":"<div >We herein report <i>para</i>-(3-phenylpropiolamido)phenyl (PPAP) glycosides as a novel class of glycosyl donors with distinct advantages for carbohydrate synthesis. These donors, featured by an intrinsically stable phenolic linkage, undergo glycosylation via a unique <i>ipso</i>-cyclization–mediated activation. Activated with <i>N</i>-iodosuccinimide (NIS)/trimethylsilyl trifluoromethanesulfonate (TMSOTf), PPAP donors support both O- and N-glycosylation across a broad range of substrates. Guided by density functional theory calculations, their design allows straightforward synthesis through a simple amide coupling reaction, facilitating diverse latent-active transformations and broadening their strategic utility. Furthermore, the distinct reactivity profile of PPAP donors—marked by a clear gap relative to other known donors and orthogonality to many standard activation methods—makes them well suited for modular, one-pot glycosylation strategies. Their ease of synthesis, robust performance in glycosylation, and compatibility with diverse assembly approaches collectively establish PPAP glycosides as powerful tools for the efficient construction of complex carbohydrates.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady4274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity 来自表达neurod1的星形胶质细胞的神经元通过转运扩增中间体转变,但缺乏功能成熟
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adw9296
Fangbing Chen, Xi Liu, Xiaowen Zhong, Xiaoqing Chen, Eva Nicholson, Kaiyi Liu, Huiyao Chen, Yifeng Lin, Yousheng Shu, Wenhao Zhou, Carol J. Schuurmans, Q. Richard Lu
{"title":"Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity","authors":"Fangbing Chen,&nbsp;Xi Liu,&nbsp;Xiaowen Zhong,&nbsp;Xiaoqing Chen,&nbsp;Eva Nicholson,&nbsp;Kaiyi Liu,&nbsp;Huiyao Chen,&nbsp;Yifeng Lin,&nbsp;Yousheng Shu,&nbsp;Wenhao Zhou,&nbsp;Carol J. Schuurmans,&nbsp;Q. Richard Lu","doi":"10.1126/sciadv.adw9296","DOIUrl":"10.1126/sciadv.adw9296","url":null,"abstract":"<div >In vivo conversion of nonneuronal cells into neurons is a proposed strategy to replace neurons lost to CNS injury or disease. Glia-to-neuron trans-differentiation by viral vector–mediated GFAP mini-promoter–driven NeuroD1 remains hotly debated. Developing inducible, lineage-traceable transgenic mice, we find that astrocyte-to-neuron conversion is restricted to a specific time window within the lesion core of injured spinal cord and brain. Spatiotemporal lineage-mapping combined with single-cell transcriptomics reveals that ectopic NeuroD1 induces astrocyte-to-neuron conversion specifically in lesion cores via transit-amplifying OLIG2<sup>+</sup> progenitors during early injury phase, but not in late phases or in nonreactive astrocytes. Neither a loss-of-function NeuroD1 mutant nor stemness-reprogramming factor SOX2 induces astrocyte-to-neuron conversion. However, contrary to previous reports, the neuronal-like cells generated by NeuroD1 lack mature neuroelectrical properties, limiting their functional integration into neural circuits. Together, our findings establish a spatiotemporal framework for NeuroD1-driven glia-to-neuron conversion, revealing a mechanistic shift from direct astrocyte conversion toward transit-amplifying intermediates and highlighting the functional immaturity of NeuroD1-converted neurons.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw9296","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrically controlled heat transport in graphite films via reversible ionic liquid intercalation 可逆离子液体插入石墨薄膜的电控热传递
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adw8588
Pietro Steiner, Saqeeb Adnan, M. Said Ergoktas, Julien Barrier, Xiaoxiao Yu, Vicente Orts, Gokhan Bakan, Jonathan Aze, Yury Malevich, Kaiyuan Wang, Pietro Cataldi, Mark Bissett, Sinan Balci, Sefik Suzer, Marat Khafizov, Coskun Kocabas
{"title":"Electrically controlled heat transport in graphite films via reversible ionic liquid intercalation","authors":"Pietro Steiner,&nbsp;Saqeeb Adnan,&nbsp;M. Said Ergoktas,&nbsp;Julien Barrier,&nbsp;Xiaoxiao Yu,&nbsp;Vicente Orts,&nbsp;Gokhan Bakan,&nbsp;Jonathan Aze,&nbsp;Yury Malevich,&nbsp;Kaiyuan Wang,&nbsp;Pietro Cataldi,&nbsp;Mark Bissett,&nbsp;Sinan Balci,&nbsp;Sefik Suzer,&nbsp;Marat Khafizov,&nbsp;Coskun Kocabas","doi":"10.1126/sciadv.adw8588","DOIUrl":"10.1126/sciadv.adw8588","url":null,"abstract":"<div >The ability to control heat transport with electrical signals has been an outstanding challenge due to the lack of efficient electrothermal materials. Previous attempts have mainly concentrated on low–thermal conductivity materials and encountered various problems such as narrow dynamic range and modest on/off ratios. Here, using high–thermal conductivity graphite films, we demonstrate an electrothermal switch enabling electrically tunable heat flow at the device level. The device uses reversible electro-intercalation of ions to modulate the in-plane thermal conductivity of graphite film by more than 13-fold via tunable phonon scattering, enabling observable modulation of the thermal conductivity at the device level. We anticipate that our results could provide a realistic pathway for adaptive thermal transport, enabling electrically driven thermal devices that would find a broad spectrum of applications in aerospace and microelectronics.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw8588","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation with reproductive isolation in the near-absence of phylogenetic signal 在几乎没有系统发育信号的情况下与生殖隔离的辐射
IF 11.7 1区 综合性期刊
Science Advances Pub Date : 2025-07-25 DOI: 10.1126/sciadv.adt0973
Martin Helmkampf, Floriane Coulmance, Melanie J. Heckwolf, Arturo Acero P., Alice Balard, Iliana Bista, Omar Dominguez Dominguez, Paul B. Frandsen, Montserrat Torres-Oliva, Aintzane Santaquiteria, Jose Tavera, Benjamin C. Victor, D. Ross Robertson, Ricardo Betancur-R., W. Owen McMillan, Oscar Puebla
{"title":"Radiation with reproductive isolation in the near-absence of phylogenetic signal","authors":"Martin Helmkampf,&nbsp;Floriane Coulmance,&nbsp;Melanie J. Heckwolf,&nbsp;Arturo Acero P.,&nbsp;Alice Balard,&nbsp;Iliana Bista,&nbsp;Omar Dominguez Dominguez,&nbsp;Paul B. Frandsen,&nbsp;Montserrat Torres-Oliva,&nbsp;Aintzane Santaquiteria,&nbsp;Jose Tavera,&nbsp;Benjamin C. Victor,&nbsp;D. Ross Robertson,&nbsp;Ricardo Betancur-R.,&nbsp;W. Owen McMillan,&nbsp;Oscar Puebla","doi":"10.1126/sciadv.adt0973","DOIUrl":"10.1126/sciadv.adt0973","url":null,"abstract":"<div >According to the genic view, species are characterized by the genes that underlie functional divergence. Here, we take a phylogenomic approach to assess this view at the scale of a whole radiation. The hamlets (<i>Hypoplectrus</i> spp.) represent a recent radiation of reef fishes from the Greater Caribbean that are reproductively isolated through assortative mating. A total of 335 genomes from 15 locations revealed a single well-supported phylogenetic split among species, with a large share of the radiation unresolved. The polytomic nature of the hamlet radiation is extreme compared to other recent radiations such as Lake Victoria cichlids. At the gene-tree level, we identified just one genomic region, centered around the <i>casz1</i> transcription factor, with a topology that reflects species differences. These results show that phenotypic diversification and reproductive isolation—two major attributes of species—may unfold in the near-absence of phylogenetic signal, both genome-wide and at the gene-tree level.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 30","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt0973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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