Science Advances最新文献

{"title":"Helical coassembly enables full-color efficient circularly polarized light emission from carbon dots with high dissymmetry factors","authors":"Jinsui Li,&nbsp;Qinghua Tan,&nbsp;Jinyang Li,&nbsp;Wendi Qin,&nbsp;Chenhao Li,&nbsp;Qian Teng,&nbsp;Yuyue Yang,&nbsp;Yifeng Wang,&nbsp;Ye Cao,&nbsp;Yuchen Hu,&nbsp;Jibin Zhang,&nbsp;Fanglong Yuan","doi":"10.1126/sciadv.adt8219","DOIUrl":"10.1126/sciadv.adt8219","url":null,"abstract":"<div >Printing materials with circularly polarized light (CPL) emission holds promise for flexible stereoscopic displays and multilevel anticounterfeiting solutions. However, a key challenge lies in developing printable CPL materials that exhibit both high photoluminescence quantum yield (PLQY) and luminescence dissymmetry factor (<i>g</i>_lum) values. In this study, we present the macroscopic and controllable production of efficient full-color CPL carbon dot (CDs) photonic paint materials. These printable CPL materials, consisting of heavy metal-free CDs as emitters, and liquid crystals as host matrices, are produced using a helical coassembly strategy. Our CPL systems based on CDs achieve high PLQY (more than 80%) and <i>g</i>_lum values (more than 1.4), with a figure of merit (a key performance indicator for CPL properties calculated by multiplying PLQY and glum) of 1.12, outperforming other CPL material systems. Furthermore, the full-color CDs-CPL is successfully used for printing flexible circularly polarized luminous patterns and multilevel anticounterfeiting features. This research provides insights into advanced CPL materials, highlighting their broad potential applications.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt8219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for the Research Article: “Targeting VPS18 hampers retromer trafficking of PD-L1 and augments immunotherapy” by T. Dong et al.","authors":"","doi":"10.1126/sciadv.ady6113","DOIUrl":"10.1126/sciadv.ady6113","url":null,"abstract":"","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aboral cell types of Clytia and coral larvae have shared features and link taurine to the regulation of settlement","authors":"Julia Ramon-Mateu,&nbsp;Anna Ferraioli,&nbsp;Núria Teixidó,&nbsp;Isabelle Domart-Coulon,&nbsp;Evelyn Houliston,&nbsp;Richard R. Copley","doi":"10.1126/sciadv.adv1159","DOIUrl":"10.1126/sciadv.adv1159","url":null,"abstract":"<div >Larval settlement is of interest both for ecologists and for evolutionary biologists, who have proposed that anterior sensory systems for substrate selection provided the basis for animal brains. Nevertheless, the cellular and molecular regulation of settlement, including in Cnidaria (corals, jellyfish, sea anemones, and hydroids), is not well understood. We generated and compared anterior (aboral) transcriptomes and single-cell RNA sequencing datasets from the planula larvae of three cnidarian species: the jellyfish <i>Clytia hemisphaerica</i> and the corals <i>Astroides calycularis</i> and <i>Pocillopora acuta</i>. Integrating these datasets and characterizing aboral cell types, we defined common cellular features of the planula aboral end and identified clade-specific specializations in cell types. Among shared features were genes implicated in taurine uptake and catabolism expressed in distinct specialized aboral cell types. In functional assays using both <i>Clytia</i> and <i>Astroides</i> planulae, exogenous taurine inhibited settlement. These findings define the molecular and cellular architecture of the planula aboral pole and implicate localized taurine destruction in regulating settlement.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv1159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ppp1r3b is a metabolic switch that shifts hepatic energy storage from lipid to glycogen","authors":"Kate Townsend Creasy,&nbsp;Minal B. Mehta,&nbsp;Carolin V. Schneider,&nbsp;Joseph Park,&nbsp;David Zhang,&nbsp;Swapnil V. Shewale,&nbsp;John S. Millar,&nbsp;Marijana Vujkovic,&nbsp;Nicholas J. Hand,&nbsp;Paul M. Titchenell,&nbsp;Joseph A. Baur,&nbsp;Daniel J. Rader","doi":"10.1126/sciadv.ado3440","DOIUrl":"10.1126/sciadv.ado3440","url":null,"abstract":"<div >The <i>PPP1R3B</i> gene, encoding PPP1R3B protein, is critical for liver glycogen synthesis and maintaining blood glucose levels. Genetic variants affecting <i>PPP1R3B</i> expression are associated with several metabolic traits and liver disease, but the precise mechanisms are not fully understood. We studied the effects of both <i>Ppp1r3b</i> overexpression and deletion in mice and cell models and found that both changes in <i>Ppp1r3b</i> expression result in dysregulated metabolism and liver damage, with overexpression increasing liver glycogen stores, while deletion resulted in higher liver lipid accumulation. These patterns were confirmed in humans where variants increasing <i>PPP1R3B</i> expression had lower liver fat and decreased plasma lipids, whereas putative loss-of-function variants were associated with increased liver fat and elevated plasma lipids. These findings support that PPP1R3B is a crucial regulator of hepatic metabolism beyond glycogen synthesis and that genetic variants affecting <i>PPP1R3B</i> expression levels influence if hepatic energy is stored as glycogen or triglycerides.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ado3440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of self-assembly behavior and ionic conductivity of conjugated liquid crystals with T-shaped facial-polyphilic structure","authors":"Ziwei Liu,&nbsp;Yangyang Sun,&nbsp;Ban Xuan Dong,&nbsp;Shrayesh N. Patel,&nbsp;Paul F. Nealey,&nbsp;Fernando A. Escobedo,&nbsp;Christopher K. Ober","doi":"10.1126/sciadv.adt8303","DOIUrl":"10.1126/sciadv.adt8303","url":null,"abstract":"<div >The unique self-assembly of liquid crystals (LCs), combined with their potential application as organic semiconductors, has become a focus of recent research. Here, a joint experimental and computational study of the self-assembly and ionic conduction was carried out on a series of T-shaped conjugated LCs consisting of three incompatible components. By extending the EOn side-chain length, several experimental evaluations confirmed a decrease of the order-disorder transition temperature, while coarse-grained simulations revealed a structural evolution from a smectic phase to a columnar phase. Ionic conductivity of these molecules was achieved by adding Li salt, leading to a maximum conductivity of 1.1 × 10⁻³ siemens per centimeter observed at 120°C. All-atom simulations were performed to examine the Li-ion solvation environment and to evaluate the intrachain and interchain Li-ion hopping mechanisms. The molecule with a long EOn side chain was found to generate a densely distributed network of Li-ion solvation sites, which can facilitate effective interchain hopping to promote ion transport.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt8303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capturing structural intermediates in an animal-like cryptochrome photoreceptor by time-resolved crystallography","authors":"Manuel Maestre-Reyna,&nbsp;Yuhei Hosokawa,&nbsp;Po-Hsun Wang,&nbsp;Martin Saft,&nbsp;Nicolas Caramello,&nbsp;Sylvain Engilberge,&nbsp;Sophie Franz-Badur,&nbsp;Eka Putra Gusti Ngurah Putu,&nbsp;Mai Nakamura,&nbsp;Wen-Jin Wu,&nbsp;Hsiang-Yi Wu,&nbsp;Cheng-Chung Lee,&nbsp;Wei-Cheng Huang,&nbsp;Kai-Fa Huang,&nbsp;Yao-Kai Chang,&nbsp;Cheng-Han Yang,&nbsp;Meng-Iao Fong,&nbsp;Wei-Ting Lin,&nbsp;Kai-Chun Yang,&nbsp;Yuki Ban,&nbsp;Tomoki Imura,&nbsp;Atsuo Kazuoka,&nbsp;Eisho Tanida,&nbsp;Shigeki Owada,&nbsp;Yasumasa Joti,&nbsp;Rie Tanaka,&nbsp;Tomoyuki Tanaka,&nbsp;Jungmin Kang,&nbsp;Fangjia Luo,&nbsp;Kensuke Tono,&nbsp;Stephan Kiontke,&nbsp;Lukas Korf,&nbsp;Yasufumi Umena,&nbsp;Takehiko Tosha,&nbsp;Yoshitaka Bessho,&nbsp;Eriko Nango,&nbsp;So Iwata,&nbsp;Antoine Royant,&nbsp;Ming-Daw Tsai,&nbsp;Junpei Yamamoto,&nbsp;Lars-Oliver Essen","doi":"10.1126/sciadv.adu7247","DOIUrl":"10.1126/sciadv.adu7247","url":null,"abstract":"<div >Animal-like cryptochromes are photoreceptors that control circadian rhythm and signaling in many eukaryotes. Transient photoreduction of the cryptochrome flavin chromophore initiated signaling via a poorly understood mechanism. By serial femtosecond crystallography (SFX), we show that the photoreduction mechanism of <i>Chlamydomonas reinhardtii</i> cryptochrome involves three loci [carboxyl-terminal region, a transient protonation pathway, and flavin adenine dinucleotide (FAD)–binding site] acting in unison to accomplish three effects: radical pair stabilization, protonation of FAD radical, and formation of the signaling state. Using 19 time-resolved SFX snapshots between 10 nanoseconds and 233 milliseconds, we found that light-driven FAD^•–/tyrosyl-373 radical pair (RP) formation primes α22 unfolding. Electron transfer–dependent protonation of aspartate-321 by tyrosine-373 is the epicenter of unfolding by disrupting salt bridges between α22 and the photolyase homology region. Before helix unfolding, another pathway opens transiently for FAD^•– protonation and RP stabilization. This link between RP formation and conformational changes provides a structural basis for signaling by animal-like cryptochromes.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu7247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The microRNA OsmiR393 regulates rice brown planthopper resistance by modulating the auxin–ROS signaling cross-talk","authors":"Lin Zhu,&nbsp;Haichao Li,&nbsp;Zhihuan Tao,&nbsp;Feilong Ma,&nbsp;Shujun Wu,&nbsp;Xuexia Miao,&nbsp;Liming Cao,&nbsp;Zhenying Shi","doi":"10.1126/sciadv.adu6722","DOIUrl":"10.1126/sciadv.adu6722","url":null,"abstract":"<div >Auxin plays critical roles in plant development and stress response. However, the roles of auxin and the immune signaling factor, reactive oxygen species (ROS), in resistance to the brown planthopper (BPH), a notorious rice-specific piercing–sucking insect that causes severe yield losses, remain unclear. We revealed that moderate naphthalene acetic acid treatment activates rice resistance to BPH, BPH infestation induces ROS accumulation, and increase in ROS content promotes BPH resistance. Underlying these phenomena, the auxin receptors OsTIR1 and OsAFB2 positively, whereas the posttranscriptional regulator OsmiR393 negatively, regulate BPH resistance. Downstream of the OsmiR393/OsTIR1 module, through successive genetic function analysis of each gene, solid genetic relationship analysis, and various biochemical assays, we established an OsmiR393/OsTIR1-OsIAA10-OsARF12-OsRbohB genetic pathway that mediates BPH resistance, in which ROS are integral. Such cross-talk between auxin and ROS reveals the intricate signaling network underlying BPH resistance, which might assist with BPH resistance breeding.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu6722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme nonlinearity by layered materials through inverse design","authors":"Zhi Zhao,&nbsp;Rahul Dev Kundu,&nbsp;Ole Sigmund,&nbsp;Xiaojia Shelly Zhang","doi":"10.1126/sciadv.adr6925","DOIUrl":"10.1126/sciadv.adr6925","url":null,"abstract":"<div >Biological materials such as seashell nacre exhibit extreme mechanical properties due to their multilayered microstructures. Collaborative interaction among these layers achieves performance beyond the capacity of a single layer. Inspired by these multilayer biological systems, we architect materials with free-form layered microstructures to program multistage snap-buckling and plateau responses—accomplishments challenging with single-layer materials. The developed inverse design paradigm simultaneously optimizes local microstructures within layers and their interconnections, enabling intricate layer interactions. Each layer plays a synergistic role in collectively achieving high-precision control over the desired extreme nonlinear responses. Through high-fidelity simulations, hybrid fabrication, and tailored experiments, we demonstrate complex responses fundamental to various functionalities, including energy dissipation and wearable devices. We orchestrate multisnapping phenomena from complex interactions between heterogeneous local architectures to encode and store information within architected materials, unlocking data encryption possibilities. These layered architected materials offer transformative advancements across diverse fields, including vibration control, wearables, and information encryption.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr6925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable chiral magneto-transport through band structure engineering in magnetic topological insulators Mn(Bi1−xSbx)2Te4","authors":"Peng Chen,&nbsp;Puyang Huang,&nbsp;Zeyu Li,&nbsp;Jieyi Liu,&nbsp;Qi Yao,&nbsp;Qiang Sun,&nbsp;Ang Li,&nbsp;Xinqi Liu,&nbsp;Yifan Zhang,&nbsp;Xinyu Cai,&nbsp;Jiuming Liu,&nbsp;Liyang Liao,&nbsp;Guanying Yang,&nbsp;Zhongkai Liu,&nbsp;Yumeng Yang,&nbsp;Xiaodong Han,&nbsp;Jin Zou,&nbsp;Thorsten Hesjedal,&nbsp;Zhenhua Qiao,&nbsp;Xufeng Kou","doi":"10.1126/sciadv.adt6084","DOIUrl":"10.1126/sciadv.adt6084","url":null,"abstract":"<div >Berry curvature and spin texture are representative tuning parameters that govern spin-orbit coupling–related physics and are also the foundation for future device applications. Here, we investigate the impact of the Sb-to-Bi ratio on shaping the electronic band structure and its correlated first- and second-harmonic magneto-transport signals in the intrinsic magnetic topological insulator Mn(Bi_1−<i>x</i>Sb<i>_x</i>)₂Te₄. First-principles calculations reveal that the introduction of Sb not only triggers a topological phase transition but also changes the integral of the Berry curvature at the shifted Fermi level, which leads to the reversal of the anomalous Hall resistance polarity for Sb fractions <i>x</i> &gt; 0.67. Moreover, it also induces the opposite spin splitting of the valence bands compared to the Sb-free host, and the resulting clockwise/counterclockwise spin chirality gives rise to a tunable unidirectional second-harmonic anomalous Hall response. Our findings pave the way for constructing chiral spin-orbitronic devices through band structure engineering.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt6084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celluloepidemiology—A paradigm for quantifying infectious disease dynamics on a population level","authors":"My K. Ha,&nbsp;Anna Postovskaya,&nbsp;Maria Kuznetsova,&nbsp;Pieter Meysman,&nbsp;Vincent Van Deuren,&nbsp;Sabrina Van Ierssel,&nbsp;Hans De Reu,&nbsp;Jolien Schippers,&nbsp;Karin Peeters,&nbsp;Hajar Besbassi,&nbsp;Leo Heyndrickx,&nbsp;Betty Willems,&nbsp;Joachim Mariën,&nbsp;Esther Bartholomeus,&nbsp;Koen Vercauteren,&nbsp;Philippe Beutels,&nbsp;Pierre Van Damme,&nbsp;Eva Lion,&nbsp;Erika Vlieghe,&nbsp;Kris Laukens,&nbsp;Samuel Coenen,&nbsp;Reinout Naesens,&nbsp;Kevin K. Ariën,&nbsp;Benson Ogunjimi","doi":"10.1126/sciadv.adt2926","DOIUrl":"10.1126/sciadv.adt2926","url":null,"abstract":"<div >To complement serology as a tool in public health interventions, we introduced the “celluloepidemiology” paradigm where we leveraged pathogen-specific T cell responses at a population level to advance our epidemiological understanding of infectious diseases, using SARS-CoV-2 as a model. Applying flow cytometry and machine learning on data from more than 500 individuals, we showed that the number of T cells with positive expression of functional markers not only could distinguish patients who recovered from COVID-19 from controls and pre-COVID donors but also identify previously unrecognized asymptomatic patients from mild, moderate, and severe recovered patients. The celluloepidemiology approach was uniquely capable to differentiate health care worker groups with different SARS-CoV-2 exposures from each other. T cell receptor (TCR) profiling strengthened our analysis by revealing that SARS-CoV-2–specific TCRs were more abundant in patients than in controls. We believe that adding data on T cell reactivity will complement serology and augment the value of infection morbidity modeling for populations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 20","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt2926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}