{"title":"Geometry-defect-spin coupling in chiral high-entropy systems: Multiscale mechanisms of GHz electromagnetic dissipation","authors":"Nan Wang, Xin Kou, Lihua Zhong, Gaoshan Zeng, Amjad Farid, Xue Zhou, Qianfeng Wang, Ding Xi, Gehong Su, Hui Huang, Yongpeng Zhao","doi":"10.1126/sciadv.adz2218","DOIUrl":"10.1126/sciadv.adz2218","url":null,"abstract":"<div >Chiral electromagnetic materials, with their unique spatial configurations, can regulate the propagation and polarization of electromagnetic waves, serving as powerful tools for tailoring electromagnetic behavior. However, their functional potential is often limited by the intrinsic constraints of conventional host materials, which typically lack sufficient flexibility in defect engineering, magnetic modulation, and spin-orbit coupling (SOC) enhancement. To address this challenge, we introduce high-entropy metal oxides (HEMOs) into carbon-based chiral frameworks, constructing HEMO and carbon nanocoil (HEMO@CNC) composites. By combining advanced microscopy, electromagnetic measurements, and density functional theory (DFT) calculations, it is revealed that increasing entropy and helical strain jointly induce nonlinear changes in SOC strength and defect-related localized states. Benefiting from these effects, the HEMO@CNC system achieves an ultrawide bandwidth, outperforming linear structures and low-entropy systems. This work provides a potential paradigm for integrating topological defect engineering and high-entropy quantum modulation, offering deeper insights into advancing electromagnetic functional materials from macroscopic design toward geometry-defect-spin synergistic regulation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz2218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-10DOI: 10.1126/sciadv.ady1667
Carl J. VanGessel, Terry J. Felderhoff, Daniil M. Prigozhin, Meihua Cui, Gael Pressoir, Adam L. Healey, John T. Lovell, Vamsi J. Nalam, Marc T. Nishimura, Geoffrey P. Morris
{"title":"Ancient pangenomic origins of noncanonical NLR genes underlying the recent evolutionary rescue of a staple crop","authors":"Carl J. VanGessel, Terry J. Felderhoff, Daniil M. Prigozhin, Meihua Cui, Gael Pressoir, Adam L. Healey, John T. Lovell, Vamsi J. Nalam, Marc T. Nishimura, Geoffrey P. Morris","doi":"10.1126/sciadv.ady1667","DOIUrl":"10.1126/sciadv.ady1667","url":null,"abstract":"<div >The recent adaptation of the cereal crop sorghum to a global aphid outbreak was a fortuitous case of evolutionary rescue, but the pangenomic and molecular basis is not known. We show that <i>RMES1</i> disrupts phloem feeding via activation of conserved immunity networks, with a growth-to-defense transition mediated by phytohormone signaling and activated by nucleotide-binding site–leucine-rich repeat receptor (NLR) resistance genes on a structural variant. The causative NLRs [resistance to <i>Melanaphis sorghi</i> 1A (RMES1A) and RMES1B] lack signaling domains and have adenosine triphosphatase mutations expected to abrogate function, suggesting that RMES1 NLRs regulate immunity via a noncanonical mechanism. The <i>RMES1</i> NLR family is ancient, orthologous to phloem-feeding resistance genes in rice and syntenic across the grass superpangenome. Thus, gene birth-and-death processes at an ancient gene cluster created rare standing variation and provided the adaptive allele for evolutionary rescue.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady1667","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-10DOI: 10.1126/sciadv.adu8455
Shengshuai Liu, Lin Li, Yujie Wang, Minghao Ning, Yanbo Lou, Yingxuan Chen, Rui Zhang, Jiabin Wang, Qinmiao Chen, Quan Yuan, Shuming Wang, Shumin Xiao, Din Ping Tsai, Ya Cheng, Shining Zhu, Jietai Jing
{"title":"Multiuser all-optical quantum network based on metasurfaces","authors":"Shengshuai Liu, Lin Li, Yujie Wang, Minghao Ning, Yanbo Lou, Yingxuan Chen, Rui Zhang, Jiabin Wang, Qinmiao Chen, Quan Yuan, Shuming Wang, Shumin Xiao, Din Ping Tsai, Ya Cheng, Shining Zhu, Jietai Jing","doi":"10.1126/sciadv.adu8455","DOIUrl":"10.1126/sciadv.adu8455","url":null,"abstract":"<div >A crucial aspect of quantum information is the establishment of multiuser quantum networks, ensuring secure transmission of information among separated users. However, establishing a large-scale network remains a substantial challenge, requiring massive and compact Einstein-Podolsky-Rosen (EPR) entangled states. Here, we experimentally generate a 5 by 5 continuous variable (CV) EPR entanglement array using a metalens array. Moreover, on the basis of such a compact EPR entanglement array, we establish a five-user all-optical quantum state sharing (AOQSS) network with fidelity beating the corresponding classical limit, which is currently the largest AOQSS network in the CV regime. These results provide a promising platform for the generation of massive and compact EPR entangled states and the construction of large-scale all-optical multiuser quantum networks. Our compact approach for generating CV EPR entanglement based on metasurface opens up avenues for advanced quantum networks.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu8455","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-10DOI: 10.1126/sciadv.adz1680
Shreya Kumbhakar, Banashree Debnath, Tuhin Kumar Maji, Binita Tongbram, Shinjan Mandal, T. Phanindra Sai, T. V. Ramakrishnan, Manish Jain, H. R. Krishnamurthy, Anshu Pandey, Arindam Ghosh
{"title":"Emergent Rashba spin-orbit coupling in bulk gold with buried network of nanoscale interfaces","authors":"Shreya Kumbhakar, Banashree Debnath, Tuhin Kumar Maji, Binita Tongbram, Shinjan Mandal, T. Phanindra Sai, T. V. Ramakrishnan, Manish Jain, H. R. Krishnamurthy, Anshu Pandey, Arindam Ghosh","doi":"10.1126/sciadv.adz1680","DOIUrl":"10.1126/sciadv.adz1680","url":null,"abstract":"<div >The Rashba effect, which plays a crucial role in fundamental materials physics and potential spintronics applications, has been engineered in diverse systems, including semiconductor quantum wells, oxide heterostructures, metallic surfaces, topological insulators, ferroelectrics, etc. However, generating it in systems that preserve bulk inversion symmetry (BIS), for example, in bulk metals, has not been possible so far. We demonstrate a strategy to introduce and tune Rashba spin-orbit interaction (SOI) to unprecedented magnitudes in inversion-symmetric solids by incorporating ultrasmall silver nanoparticles in bulk gold. The near-identical lattice constants of Ag and Au allow dense packing of the Ag/Au hetero-interfaces without compromising the global BIS. By varying the density of embedded nanoparticles, we generate Rashba SOI in a bulk metal with coupling strength ~15 meV∙Å, higher than any known system preserving BIS globally, and show up to ~20 times increase in the spin-orbit scattering rate. We argue that the combined effect of charge transfer at the interfaces and polaronic localization enhances the SOI.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz1680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A DNA-containing phase-separated compartment links the nuclear envelope to chromosome axes to promote homolog pairing in C. elegans","authors":"Ruoxi Wang, Yuqi Tian, Libo Liu, Jian-Hua Wang, Li Zhao, Yuanyuan Liu, Feifei Qi, Liangran Zhang, Jun Zhou, Meng-Qiu Dong, Jinmin Gao","doi":"10.1126/sciadv.adw5764","DOIUrl":"10.1126/sciadv.adw5764","url":null,"abstract":"<div >Homologous chromosome pairing is a critical prerequisite for successful meiosis, yet the molecular mechanisms underlying this process remain elusive. In <i>Caenorhabditis elegans</i>, chromosome pairing centers (PCs) and PC-recruited proteins mediate homolog recognition and pairing. Here, we further dissect the molecular characteristics of this system and reveal the involvement of a phase-separated compartment in pairing. Focusing on the PC protein HIM-8, we explored its functional domains in vivo and its self-multimerizing properties in vitro. We find that the amino-terminal domain facilitates PC chromatin binding of the carboxyl-terminal domain, whereas the middle unstructured region is essential for PC association with the nuclear envelop (NE). Integrated analyses suggest that PC-NE association is mediated by a DNA-containing phase-separated compartment that is spatially distinct from, but connected to, the chromosome axis—likely through flexible linkages. We propose that homology evaluation occurs within this compartment, where direct DNA-DNA interactions could play a role.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw5764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-10DOI: 10.1126/sciadv.adw6401
Nika Žibrat Kalanj, Andreja Prešern, Katerina Naumoska, Tina Snoj, Jana Aupič, Vesna Glavnik, Alen Albreht, Mojca Mally, Jure Derganc, Peter Greimel, Alessandra Magistrato, Gregor Anderluh
{"title":"Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides","authors":"Nika Žibrat Kalanj, Andreja Prešern, Katerina Naumoska, Tina Snoj, Jana Aupič, Vesna Glavnik, Alen Albreht, Mojca Mally, Jure Derganc, Peter Greimel, Alessandra Magistrato, Gregor Anderluh","doi":"10.1126/sciadv.adw6401","DOIUrl":"10.1126/sciadv.adw6401","url":null,"abstract":"<div >Interactions between plants and pathogens pose a major challenge for plant health and agriculture. One type of threat comes from widespread cytolysins necrosis- and ethylene-inducing peptide 1–like proteins (NLPs) secreted by microbial pathogens. NLPs disrupt plant membranes through interactions with glycosylinositol phosphorylceramides (GIPCs), but the specificity of these interactions remains unclear. We studied binding and pore formation of NLPs in model membranes with GIPCs derived from dicotyledonous or monocotyledonous plants. Using the cytotoxic NLP 2 from fungus <i>Moniliophthora perniciosa</i> (MpNEP2), we show that membrane binding and damage extend beyond previously studied oomycetal NLPs. Furthermore, NLP<sub>Pya</sub> from the oomycete <i>Pythium aphanidermatum</i> exhibits promiscuous binding with a marked preference for branched GIPC series B lipids. Molecular dynamics simulations demonstrated that the structural plasticity of NLP<sub>Pya</sub> provides a rational basis for its interaction with a variety of GIPC headgroups. These results clarify the molecular basis of NLP cytotoxicity and emphasize their role in broad-spectrum pathogenicity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw6401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-10DOI: 10.1126/sciadv.adw7181
Yue Guo, Mingjing Xu, Hua Xue, Xiaofan Ding, Alissa M. Wong, Na Lin, Dandan Pu, Aikha M. Wong, Xin Wang, Hui Zhao, Nathalie Wong
{"title":"Genome-wide CRISPR screen identifies splicing factor SF3B4 in driving hepatocellular carcinoma","authors":"Yue Guo, Mingjing Xu, Hua Xue, Xiaofan Ding, Alissa M. Wong, Na Lin, Dandan Pu, Aikha M. Wong, Xin Wang, Hui Zhao, Nathalie Wong","doi":"10.1126/sciadv.adw7181","DOIUrl":"10.1126/sciadv.adw7181","url":null,"abstract":"<div >Although genome sequencings have recognized many cancer-associated genes in hepatocellular carcinoma (HCC), distinguishing their functional effect remains challenging. Leveraging on a genome-wide CRISPR knockout (KO) screening, we uncovered spliceosome factors as major survival essential genes in HCC and up-regulations of ferroptosis suppressors [particularly glutamate-cysteine ligase catalytic subunit (GCLC)] in lenvatinib resistance. Our KO screen in patient-derived HCC organoid showed splicing factor 3b subunit 4 (SF3B4) to be top-ranked, conferring prosurvival signal in HCC organoid and driving tumorigenic potentials in both hepatic progenitor organoids and hydrodynamic tail vein injection HCC murine model. The combined RNA immunoprecipitation sequencing, long-read isoform sequencing, and transcriptome revealed characteristic splicing landscape regulated by SF3B4 and identified T-box transcription factor 3 (TBX3) variant TBX3+2a as a potent downstream effector. Our findings highlighted vital roles of SF3B4 in HCC cell survival and tumor progression, and the phenomenon of ferroptosis resistance in patients unresponsive to first-line agent lenvatinib.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-10DOI: 10.1126/sciadv.adw3110
Núria Planell, Xabier Martínez-de-Morentin, Daniel Mouzo, David Lara-Astiaso, Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Diego Alignani, Bruno Paiva, Alberto Maillo, Aleksandra Kurowska, Nerea Berastegui, Paula Garcia-Olloqui, Arantxa Urdangarin, Peri Noori, Asier Ortega-Legarreta, Mikel Hernaez, Vincenzo Lagani, Narsis Kiani, Matthias Merkenschlager, Teresa Ezponda, José I. Martín-Subero, Ricardo N. Ramírez, Jesper Tegner, Felipe Prosper, David Gomez-Cabrero
{"title":"Uncovering the regulatory landscape of early human B cell lymphopoiesis and its implications in the pathogenesis of B-ALL","authors":"Núria Planell, Xabier Martínez-de-Morentin, Daniel Mouzo, David Lara-Astiaso, Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Diego Alignani, Bruno Paiva, Alberto Maillo, Aleksandra Kurowska, Nerea Berastegui, Paula Garcia-Olloqui, Arantxa Urdangarin, Peri Noori, Asier Ortega-Legarreta, Mikel Hernaez, Vincenzo Lagani, Narsis Kiani, Matthias Merkenschlager, Teresa Ezponda, José I. Martín-Subero, Ricardo N. Ramírez, Jesper Tegner, Felipe Prosper, David Gomez-Cabrero","doi":"10.1126/sciadv.adw3110","DOIUrl":"10.1126/sciadv.adw3110","url":null,"abstract":"<div >Dysregulation of early B cell lymphopoiesis—the process guiding cellular immunity development—can lead to malignancy, making it crucial to understand its regulatory mechanisms. We generated a multiomics resource comprising paired chromatin accessibility and gene expression profiles across eight human B cell precursor populations, providing a detailed characterization of early human B cell development. Integrative analysis revealed highly cell type–specific regulatory elements and enabled the reconstruction of the gene regulatory network governing differentiation. We identified putative candidate regulons, such as ELK3, enriched in pro–B cells and potentially involved in cell cycle progression. Regulons from bulk data were projected onto single-cell data, validating their activity and refining the regulatory landscape. This resource enabled identification of active regulatory programs and transformation-associated states in B cell acute lymphoblastic leukemia. The publicly available atlas provides a valuable resource for understanding B cell development and disease, supporting future efforts to decode regulatory programs in immunity and hematologic malignancies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw3110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-10-10DOI: 10.1126/sciadv.adw5444
Laure Cazals, Agnès Desolneux, Simo Huotari, Lauren Dalecky, Christoph Sahle, Alessandro Mirone, Serge X. Cohen, Loïc Bertrand
{"title":"Digital twin enables radiosensitive organic speciation in 3D","authors":"Laure Cazals, Agnès Desolneux, Simo Huotari, Lauren Dalecky, Christoph Sahle, Alessandro Mirone, Serge X. Cohen, Loïc Bertrand","doi":"10.1126/sciadv.adw5444","DOIUrl":"10.1126/sciadv.adw5444","url":null,"abstract":"<div >State-of-the-art spectral imaging techniques using high-brilliance sources face an inherent trade-off between signal intensity and sample integrity, particularly in hyperspectral and multispectral imaging. Traditionally, optimizing acquisition parameters, such as source wavelength, intensity, and exposure time, relies on empirical adjustments to enhance image contrast. Here, we introduce a digital twin methodology to overcome these limitations. Focusing on x-ray Raman imaging, a powerful yet underutilized speciation probe constrained by low quantum efficiency, we demonstrate its application to sensitive organic samples. Our approach enabled a 10-fold reduction in acquisition time while maintaining operation below the damage threshold, paving the way for high-fidelity spectral imaging with minimal sample degradation.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw5444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Focused thermal energy at atomic microwave antenna sites for ecocatalysis","authors":"Ryo Ishibashi, Fuminao Kishimoto, Tatsushi Yoshioka, Hiroki Yamada, Koki Muraoka, Toshiaki Ina, Hiroki Taniguchi, Akira Nakayama, Toru Wakihara, Kazuhiro Takanabe","doi":"10.1126/sciadv.ady4043","DOIUrl":"10.1126/sciadv.ady4043","url":null,"abstract":"<div >Green transformation demands efficient protocols to convert renewable energy into usable forms. Microwave (MW)–driven catalytic systems offer a promising electrification strategy for chemical processes by enabling targeted, energy-efficient reactions. Unlike conventional heating, MW irradiation can localize energy at catalytic active sites. A major breakthrough is the selective MW heating of isolated metal ions or nanoparticles. This study presents a general catalyst design strategy to control MW-induced heating of single metal ions by tuning the zeolite framework and electrostatic interactions. Key structural and electronic factors governing atomic-scale energy localization are identified. Applying this approach to the reverse water-gas shift reaction results in energy efficiency improvements via targeted heating of single-ion sites. These findings mark a milestone in MW-assisted catalysis, establishing a framework for using MW energy in heterogeneous systems. The work introduces design principles for single-atom-antenna MW catalysts, advancing the development of next-generation catalytic reactors driven by electromagnetic energy.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 41","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady4043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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