Science Advances最新文献_第3页

Regional differences in three-dimensional fiber organization, smooth muscle cell phenotype, and contractility in the pregnant mouse cervix

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adr3530

Christopher J. Hansen, Jackson H. Rogers, Alexus J. Brown, Naoko Boatwright, Shajila Siricilla, Christine M. O’Brien, Sourav Panja, Cameron M. Nichols, Kanchana Devanathan, Benjamin M. Hardy, Mark D. Does, Adam W. Anderson, Bibhash C. Paria, Anita Mahadevan-Jansen, Jeff Reese, Jennifer L. Herington

{"title":"Regional differences in three-dimensional fiber organization, smooth muscle cell phenotype, and contractility in the pregnant mouse cervix","authors":"Christopher J. Hansen, Jackson H. Rogers, Alexus J. Brown, Naoko Boatwright, Shajila Siricilla, Christine M. O’Brien, Sourav Panja, Cameron M. Nichols, Kanchana Devanathan, Benjamin M. Hardy, Mark D. Does, Adam W. Anderson, Bibhash C. Paria, Anita Mahadevan-Jansen, Jeff Reese, Jennifer L. Herington","doi":"10.1126/sciadv.adr3530","DOIUrl":"https://doi.org/10.1126/sciadv.adr3530","url":null,"abstract":"The orientation and function of smooth muscle in the cervix may contribute to the important biomechanical properties that change during pregnancy. Thus, this study examined the three-dimensional structure, smooth muscle phenotype, and mechanical and contractile functions of the upper and lower cervix of nongravid (not pregnant) and gravid (pregnant) mice. In gravid cervix, we uncovered region-specific changes in the structure and organization of fiber tracts. We also detected a greater proportion of contractile smooth muscle cells (SMCs), but an equal proportion of synthetic SMCs, in the upper versus lower cervix. Furthermore, we revealed that the lower cervix had infrequent spontaneous contractions, distension had a minimal effect on contractility, and the upper cervix had forceful contractions in response to labor-inducing agents (oxytocin and prostaglandin E 2 ). These findings identify regional differences in cervix contractility related to contractile SMC content and fiber organization, which could be targeted with diagnostic technologies and for therapeutic intervention.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"30 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanosensitive nuclear uptake of chemotherapy 化疗的机敏核吸收

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adr5947

Nicholas R. Scott, Sowon Kang, Sapun H. Parekh

引用次数: 0

The Plasmodium falciparum NCR1 transporter is an antimalarial target that exports cholesterol from the parasite’s plasma membrane 恶性疟原虫 NCR1 转运体是一种抗疟靶标，可将胆固醇从寄生虫的质膜中排出

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adq6651

Zhemin Zhang, Meinan Lyu, Xu Han, Sepalika Bandara, Meng Cui, Eva S. Istvan, Xinran Geng, Marios L. Tringides, William D. Gregor, Masaru Miyagi, Jenna Oberstaller, John H. Adams, Youwei Zhang, Marvin T. Nieman, Johannes von Lintig, Daniel E. Goldberg, Edward W. Yu

{"title":"The Plasmodium falciparum NCR1 transporter is an antimalarial target that exports cholesterol from the parasite’s plasma membrane","authors":"Zhemin Zhang, Meinan Lyu, Xu Han, Sepalika Bandara, Meng Cui, Eva S. Istvan, Xinran Geng, Marios L. Tringides, William D. Gregor, Masaru Miyagi, Jenna Oberstaller, John H. Adams, Youwei Zhang, Marvin T. Nieman, Johannes von Lintig, Daniel E. Goldberg, Edward W. Yu","doi":"10.1126/sciadv.adq6651","DOIUrl":"https://doi.org/10.1126/sciadv.adq6651","url":null,"abstract":"Malaria, a devastating parasitic infection, is the leading cause of death in many developing countries. Unfortunately, the most deadliest causative agent of malaria, Plasmodium falciparum , has developed resistance to nearly all currently available antimalarial drugs. The P. falciparum Niemann-Pick type C1–related (PfNCR1) transporter has been identified as a druggable target, but its structure and detailed molecular mechanism are not yet available. Here, we present three structures of PfNCR1 with and without the functional inhibitor MMV009108 at resolutions between 2.98 and 3.81 Å using single-particle cryo–electron microscopy (cryo-EM), suggesting that PfNCR1 binds cholesterol and forms a cholesterol transport tunnel to modulate the composition of the parasite plasma membrane. Cholesterol efflux assays show that PfNCR1 is an exporter capable of extruding cholesterol from the membrane. Additionally, the inhibition mechanism of MMV009108 appears to be due to a direct blockage of PfNCR1, preventing this transporter from shuttling cholesterol.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"47 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral flat-band optical cavity with atomically thin mirrors 带原子级薄反射镜的手性平带光腔

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adr5904

Daniel G. Suárez-Forero, Ruihao Ni, Supratik Sarkar, Mahmoud Jalali Mehrabad, Erik Mechtel, Valery Simonyan, Andrey Grankin, Kenji Watanabe, Takashi Taniguchi, Suji Park, Houk Jang, Mohammad Hafezi, You Zhou

{"title":"Chiral flat-band optical cavity with atomically thin mirrors","authors":"Daniel G. Suárez-Forero, Ruihao Ni, Supratik Sarkar, Mahmoud Jalali Mehrabad, Erik Mechtel, Valery Simonyan, Andrey Grankin, Kenji Watanabe, Takashi Taniguchi, Suji Park, Houk Jang, Mohammad Hafezi, You Zhou","doi":"10.1126/sciadv.adr5904","DOIUrl":"https://doi.org/10.1126/sciadv.adr5904","url":null,"abstract":"A fundamental requirement for photonic technologies is the ability to control the confinement and propagation of light. Widely used platforms include two-dimensional (2D) optical microcavities in which electromagnetic waves are confined in either metallic or distributed Bragg reflectors. Recently, transition metal dichalcogenides hosting tightly bound excitons with high optical quality have emerged as promising atomically thin mirrors. In this work, we propose and experimentally demonstrate a subwavelength 2D nanocavity using two atomically thin mirrors with degenerate resonances. Angle-resolved measurements show a flat band, which sets this system apart from conventional photonic cavities. We demonstrate how the excitonic nature of the mirrors enables the formation of chiral and tunable optical modes upon the application of an external magnetic field. Moreover, we show the electrical tunability of the confined mode. Our work demonstrates a mechanism for confining light with high-quality excitonic materials, opening perspectives for spin-photon interfaces, and chiral cavity electrodynamics.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"41 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An agile multimodal microrobot with architected passively morphing wheels

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adp1176

Yuchen Lai, Chuanqi Zang, Guoquan Luo, Shiwei Xu, Renheng Bo, Jianzhong Zhao, Youzhou Yang, Tianqi Jin, Yu Lan, Yuejiao Wang, Li Wen, Wenbo Pang, Yihui Zhang

{"title":"An agile multimodal microrobot with architected passively morphing wheels","authors":"Yuchen Lai, Chuanqi Zang, Guoquan Luo, Shiwei Xu, Renheng Bo, Jianzhong Zhao, Youzhou Yang, Tianqi Jin, Yu Lan, Yuejiao Wang, Li Wen, Wenbo Pang, Yihui Zhang","doi":"10.1126/sciadv.adp1176","DOIUrl":"https://doi.org/10.1126/sciadv.adp1176","url":null,"abstract":"Multimodal microrobots are of growing interest due to their capabilities to navigate diverse terrains, with promising applications in inspection, exploration, and biomedicine. Despite remarkable progress, it remains challenging to combine the attributes of excellent maneuverability, low power consumption, and high robustness in a single multimodal microrobot. We propose an architected design of a passively morphing wheel that can be stabilized at distinct geometric configurations, relying on asymmetric bending stiffness of bioinspired tentacle structures. By integrating such wheels with electromagnetic motors and a flexible body, we develop a highly compact, lightweight, multimodal microrobot (length ~32 mm and mass ~4.74 g) with three locomotion gaits. It has high motion speed (~21.2 BL/s), excellent agility (relative centripetal acceleration, ~206.9 BL/s 2 ), low power consumption (cost of transport, ~89), high robustness, and strong terrain adaptabilities. Integration of batteries and a wireless control module enables developments of an untethered microrobot that maintains high motion speed and excellent agility, with capabilities of traveling in hybrid terrains.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"256 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Probing quantum geometry through optical conductivity and magnetic circular dichroism 通过光导率和磁圆二色性探测量子几何

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.ado1761

Barun Ghosh, Yugo Onishi, Su-Yang Xu, Hsin Lin, Liang Fu, Arun Bansil

引用次数: 0

The nucleocapsid architecture and structural atlas of the prototype baculovirus define the hallmarks of a new viral realm

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.ado2631

Bronte A. Johnstone, Joshua M. Hardy, Jungmin Ha, Anamarija Butkovic, Paulina Koszalka, Cathy Accurso, Hariprasad Venugopal, Alex de Marco, Mart Krupovic, Fasséli Coulibaly

{"title":"The nucleocapsid architecture and structural atlas of the prototype baculovirus define the hallmarks of a new viral realm","authors":"Bronte A. Johnstone, Joshua M. Hardy, Jungmin Ha, Anamarija Butkovic, Paulina Koszalka, Cathy Accurso, Hariprasad Venugopal, Alex de Marco, Mart Krupovic, Fasséli Coulibaly","doi":"10.1126/sciadv.ado2631","DOIUrl":"https://doi.org/10.1126/sciadv.ado2631","url":null,"abstract":"Baculovirus is the most studied insect virus owing to a broad ecological distribution and ease of engineering for biotechnological applications. However, its structure and evolutionary place in the virosphere remain enigmatic. Using cryo–electron microscopy, we show that the nucleocapsid forms a covalently cross-linked helical tube protecting a highly compacted 134-kilobase pair DNA genome. The ends of the tube are sealed by the base and cap substructures, which share a 126-subunit hub but differ in components that promote actin tail–mediated propulsion and nuclear entry of the nucleocapsid, respectively. Unexpectedly, sensitive searches for hidden evolutionary links show that the morphogenetic machinery and conserved oral infectivity factors originated within the lineage of baculo-like viruses (class Naldaviricetes ). The unique viral architecture and structural atlas of hallmark proteins firmly place these viruses into a separate new realm, the highest taxonomy rank, and provide a structural framework to expand their use as sustainable bioinsecticides and biomedical tools.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"23 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inferring context-dependent computations through linear approximations of prefrontal cortex dynamics 通过前额叶皮层动态的线性近似推断依赖于上下文的计算

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adl4743

Joana Soldado-Magraner, Valerio Mante, Maneesh Sahani

{"title":"Inferring context-dependent computations through linear approximations of prefrontal cortex dynamics","authors":"Joana Soldado-Magraner, Valerio Mante, Maneesh Sahani","doi":"10.1126/sciadv.adl4743","DOIUrl":"https://doi.org/10.1126/sciadv.adl4743","url":null,"abstract":"The complex neural activity of prefrontal cortex (PFC) is a hallmark of cognitive processes. How these rich dynamics emerge and support neural computations is largely unknown. Here, we infer mechanisms underlying the context-dependent integration of sensory inputs by fitting dynamical models to PFC population responses of behaving monkeys. A class of models implementing linear dynamics driven by external inputs accurately captured PFC responses within contexts and revealed equally performing mechanisms. One model implemented context-dependent recurrent dynamics and relied on transient input amplification; the other relied on subtle contextual modulations of the inputs, providing constraints on the attentional effects in sensory areas required to explain flexible PFC responses and behavior. Both models revealed properties of inputs and recurrent dynamics that were not apparent from qualitative descriptions of PFC responses. By revealing mechanisms that are quantitatively consistent with complex cortical dynamics, our modeling approach provides a principled and general framework to link neural population activity and computation.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"14 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A global comparison of surface and subsurface microbiomes reveals large-scale biodiversity gradients, and a marine-terrestrial divide

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adq0645

S. Emil Ruff, Isabella Hrabe de Angelis, Megan Mullis, Jérôme P. Payet, Cara Magnabosco, Karen G. Lloyd, Cody S. Sheik, Andrew D. Steen, Anna Shipunova, Aleksey Morozov, Brandi Kiel Reese, James A. Bradley, Clarisse Lemonnier, Matthew O. Schrenk, Samantha B. Joye, Julie A. Huber, Alexander J. Probst, Hilary G. Morrison, Mitchell L. Sogin, Joshua Ladau, Frederick Colwell

{"title":"A global comparison of surface and subsurface microbiomes reveals large-scale biodiversity gradients, and a marine-terrestrial divide","authors":"S. Emil Ruff, Isabella Hrabe de Angelis, Megan Mullis, Jérôme P. Payet, Cara Magnabosco, Karen G. Lloyd, Cody S. Sheik, Andrew D. Steen, Anna Shipunova, Aleksey Morozov, Brandi Kiel Reese, James A. Bradley, Clarisse Lemonnier, Matthew O. Schrenk, Samantha B. Joye, Julie A. Huber, Alexander J. Probst, Hilary G. Morrison, Mitchell L. Sogin, Joshua Ladau, Frederick Colwell","doi":"10.1126/sciadv.adq0645","DOIUrl":"https://doi.org/10.1126/sciadv.adq0645","url":null,"abstract":"Subsurface environments are among Earth’s largest habitats for microbial life. Yet, until recently, we lacked adequate data to accurately differentiate between globally distributed marine and terrestrial surface and subsurface microbiomes. Here, we analyzed 478 archaeal and 964 bacterial metabarcoding datasets and 147 metagenomes from diverse and widely distributed environments. Microbial diversity is similar in marine and terrestrial microbiomes at local to global scales. However, community composition greatly differs between sea and land, corroborating a phylogenetic divide that mirrors patterns in plant and animal diversity. In contrast, community composition overlaps between surface to subsurface environments supporting a diversity continuum rather than a discrete subsurface biosphere. Differences in microbial life thus seem greater between land and sea than between surface and subsurface. Diversity of terrestrial microbiomes decreases with depth, while marine subsurface diversity and phylogenetic distance to cultured isolates rivals or exceeds that of surface environments. We identify distinct microbial community compositions but similar microbial diversity for Earth’s subsurface and surface environments.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"30 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomic age (MileAge) predicts health and life span: A comparison of multiple machine learning algorithms 代谢组年龄（MileAge）可预测健康和寿命：多种机器学习算法的比较

IF 13.6 1区综合性期刊

Science Advances Pub Date : 2024-12-18 DOI: 10.1126/sciadv.adp3743

Julian Mutz, Raquel Iniesta, Cathryn M. Lewis

{"title":"Metabolomic age (MileAge) predicts health and life span: A comparison of multiple machine learning algorithms","authors":"Julian Mutz, Raquel Iniesta, Cathryn M. Lewis","doi":"10.1126/sciadv.adp3743","DOIUrl":"https://doi.org/10.1126/sciadv.adp3743","url":null,"abstract":"Biological aging clocks produce age estimates that can track with age-related health outcomes. This study aimed to benchmark machine learning algorithms, including regularized regression, kernel-based methods, and ensembles, for developing metabolomic aging clocks from nuclear magnetic resonance spectroscopy data. The UK Biobank data, including 168 plasma metabolites from up to N = 225,212 middle-aged and older adults (mean age, 56.97 years), were used to train and internally validate 17 algorithms. Metabolomic age (MileAge) delta, the difference between metabolite-predicted and chronological age, from a Cubist rule–based regression model showed the strongest associations with health and aging markers. Individuals with an older MileAge were frailer, had shorter telomeres, were more likely to suffer from chronic illness, rated their health worse, and had a higher all-cause mortality hazard (HR = 1.51; 95% CI, 1.43 to 1.59; P < 0.001). This metabolomic aging clock (MileAge) can be applied in research and may find use in health assessments, risk stratification, and proactive health tracking.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"4 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0