ACS Energy Letters 最新文献

{"title":"Chemical-Driven Amyloid Clearance for Therapeutics and Diagnostics of Alzheimer's Disease.","authors":"Hye Yun Kim, YoungSoo Kim","doi":"10.1021/acs.accounts.4c00458","DOIUrl":"10.1021/acs.accounts.4c00458","url":null,"abstract":"<p><p>ConspectusA century ago, German neurologist Alois Alzheimer documented the first case of Alzheimer's disease (AD), illuminating cognitive impairments associated with the presence of abnormal protein clusters, including amyloid plaques and tau tangles, within the brain. In a typical physiological state, the equilibrium of amyloid-β (Aβ) levels is maintained, but aging can precipitate disruptions in the homeostasis of Aβ due to its overproduction, impaired clearance, and other factors, ultimately leading to its accumulation. Although the link between Aβ aggregates and neurodegeneration has long made Aβ a promising target for AD, decades without successful drug development targeting Aβ have generated skepticism regarding the efficacy of this strategy for AD therapy. However, recent approvals of anti-Aβ antibody drugs by the FDA, including aducanumab (Aduhelm), lecanemab (Leqembi), and donanemab (Kisunla), have prompted a re-evaluation of this perspective. These therapies have demonstrated efficacy in reducing brain Aβ levels, thereby decelerating disease progression and reaffirming Aβ as a key target. Despite advancements, immunotherapies are accompanied by considerable disadvantages, including adverse effects, high costs, and cumbersome administration. To address these limitations, our research has focused on developing small molecules that can mitigate the challenges of antibody treatments while offering practical and accessible options. We identified 4-(2-hydroxyethyl)-1-piperazine propanesulfonic acid (EPPS) as a promising compound that significantly reduces aggregated Aβ in the brain and enhances behavior in AD rodent models. Following administration, EPPS penetrates the blood-brain barrier (BBB) and binds to toxic Aβ aggregates, subsequently breaking them down into nontoxic monomers. This leads to two significant outcomes: a reduction of Aβ aggregates in the brain and a subsequent increase in Aβ monomers in blood. The monomeric Aβ, unlike its aggregated form, can now traverse the BBB and enter the bloodstream. This mechanism provides an innovative approach to AD treatment and diagnosis. By detaching cerebral Aβ aggregates, EPPS facilitates Aβ clearance and addresses a key pathological feature of AD. Concurrently, the increase in blood Aβ levels offers a potential biomarker for monitoring treatment efficacy and disease progression, thereby revolutionizing both AD treatment and diagnosis. Investigating the detailed mode of action of drug candidates requires structural information about a target protein. Unfortunately, the unstable and heterogeneous nature of Aβ aggregates, which form larger clusters, complicates the identification of these structures. Therefore, we developed new tools for screening small molecules by immobilizing monomeric Aβ and its fragments on plates. This allows us not only to identify novel compounds that target Aβ but also to elucidate their mechanisms of action, enabling the development of Aβ-targeting therapeutic a","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":" ","pages":"3266-3276"},"PeriodicalIF":19.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pd(NHC)(μ-Cl)Cl]₂: The Highly Reactive Air- and Moisture-Stable, Well-Defined Pd(II)-N-Heterocyclic Carbene (NHC) Complexes for Cross-Coupling Reactions.","authors":"Shiyi Yang, Tongliang Zhou, Xiang Yu, Steven P Nolan, Michal Szostak","doi":"10.1021/acs.accounts.4c00549","DOIUrl":"10.1021/acs.accounts.4c00549","url":null,"abstract":"<p><p>ConspectusPalladium-catalyzed cross-coupling reactions owing to their high specificity and superb chemoselectivity represent a powerful tool for the rapid construction of C-C and C-X bonds across various areas of chemical research, including pharmaceutical development, polymer and agrochemical industries, bioactive natural products, and advanced functional materials, rendering them indispensable for modern synthetic chemists. The major driving force for the advances in this critical field is the design of increasingly more reactive and more selective ligands and precatalysts that aim not only to address challenging cross-coupling processes but also to achieve optimal reactivity, selectivity, and functional group compatibility under mild, user-friendly, operationally simple, and broadly applicable conditions. In this context, Pd(II)-N-heterocyclic carbene complexes (NHC = N-heterocyclic carbene) have garnered prevalent attention among practitioners of organic synthesis due to their unique electronic and steric characteristics that are unmatched among other ligands. In particular, the superior σ-donating ability of NHC ligands in conjunction with conformational flexibility as well as the ease of steric and electronic modification and high stability to air and moisture enable highly effective fundamental elementary steps in catalytic cycles and facile formation of well-defined complexes.The key factor in the design of well-defined, air- and moisture-stable Pd(II) precatalysts involves the incorporation of supporting ligands, which are essential for ensuring the stability of Pd(II)-NHC complexes and facile activation of Pd(II)-NHC precatalysts to catalytically active monoligated Pd(0)-NHC species under the reaction conditions. Notably, [Pd(NHC)(μ-Cl)Cl]<sub>2</sub> chloro dimers, which can be readily synthesized via a one-pot, atom-economic process, are the most reactive Pd(II)-NHC complexes synthesized to date. These well-defined, air- and moisture-stable dimers readily dissociate to monomers and are activated to Pd(0)-NHC catalysts under both mild and strong base conditions, showcasing enhanced reactivity and selectivity among their Pd(II)-NHC counterparts. This balance between high, operationally simple stability, which is characteristic of Pd(II) complexes together with the ease of activation to the strongly nucleophilic Pd(0)-NHC catalysts, renders [Pd(NHC)(μ-Cl)Cl]<sub>2</sub> the most reactive Pd(II)-NHC precatalysts developed to date for a broad range of general cross-coupling processes, including C-X, C-O, C-N, and C-S activation and enabling the direct late-stage functionalization of complex compounds decorated with a wide range of sensitive functional groups.In this Account, we outline [Pd(NHC)(μ-Cl)Cl]<sub>2</sub> as a highly reactive Pd(II)-NHC precatalyst that should be routinely used as the first choice Pd complexes for a wide range of challenging cross-coupling reactions. The advancements in this field over the past 20 years emp","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":" ","pages":"3343-3355"},"PeriodicalIF":19.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Stabilization Designs for Enhanced Therapeutic Efficacy and Accessibility.","authors":"Yanxian Zhang, Maxwell Jack Austin, Danny Hung-Chieh Chou","doi":"10.1021/acs.accounts.4c00500","DOIUrl":"10.1021/acs.accounts.4c00500","url":null,"abstract":"<p><p>ConspectusInsulin has remained indispensable in the treatment of diabetes since it was first discovered in 1921. Unlike small molecular drugs, insulin and other protein drugs are prone to degradation when exposed to elevated temperatures, mechanical agitation during transportation, and prolonged storage periods. Therefore, strict cold-chain management is crucial for the insulin supply, requiring significant resources, which can limit the access to insulin, particularly in low-income areas. Moreover, although insulin formulations have advanced tremendously in the last century, insulin treatment still imposes a challenging regimen and provides suboptimal outcomes for the majority of patients. There is an increasing focus on pursuing improved pharmacology, specifically on safer, more user-friendly insulin therapies that minimize the self-management burden. These challenges underscore the need for developing novel insulin formulations with improved stability that are compatible with advanced insulin therapy.Insulin stabilization can be achieved through either chemical modification of insulin or formulation component design. Inspired by insulin-like peptides from invertebrates, we have developed novel stable insulin analogs based on a fundamental understanding of the insulin receptor engagement for insulin bioactivity. We created a novel four-disulfide insulin analog with high aggregation stability and potency by introducing a fourth disulfide bond between a C-terminal extended insulin A-chain and residues near the C-terminus of the B-chain. In an effort to stabilize insulin in its monomeric state to develop ultrafast-acting insulin with rapid absorption upon injection, we have developed a series of structurally miniaturized yet fully active insulin analogs that do not form dimers due to the lack of the canonical B-chain C-terminal octapeptide. Additionally, our study provided strategies for expanding the scope of cucurbit[7]uril (CB[7])-assisted insulin stabilization by engineering safe and biodegradable CB[7]-zwitterionic polypeptide excipients. We also explored insulin N-terminal substitution methods to achieve pH-dependent insulin stabilization without prolonging the duration of action.This Account describes our exploration of engineering stable insulin analogs and formulation design strategies for stabilizing insulin in aqueous solutions. Beyond conventional stabilization strategies for insulin injections, the unmet challenges and recent innovations in insulin stabilization are discussed, addressing the growing demand for alternative, less invasive routes of insulin administration. Additionally, we aim to provide a thorough overview of insulin stabilization from the perspective of commercially available insulin drugs and common pharmaceutical engineering practices in the industry. We also highlight unresolved insulin stabilization challenges and ongoing research strategies. We anticipate that further emphasis on collective efforts of protei","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":" ","pages":"3303-3315"},"PeriodicalIF":19.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misfit Layered Compounds: Insights into Chemical, Kinetic, and Thermodynamic Stability of Nanophases.","authors":"Azat Khadiev, M B Sreedhara, Simon Hettler, Dmitri Novikov, Raul Arenal, Reshef Tenne","doi":"10.1021/acs.accounts.4c00412","DOIUrl":"10.1021/acs.accounts.4c00412","url":null,"abstract":"<p><p>ConspectusCompounds with layered structures (2D-materials), like transition metal-dichalcogenides (e.g., MoS<sub>2</sub>), attracted a great deal of interest in the scientific community in recent years. This interest can be attributed to their unique lamellar structure, which induces large anisotropy in their physicochemical properties. Furthermore, owing to the weak van der Waals interaction between the layers, they can be cleaved along the <i>a-b</i> plane, which allows fabricating single layers with physical properties entirely different from the bulk material. Moreover, stacking layers of different 2D-materials on top of each other has led to a wealth of new observations, for instance, by twisting two layers with respect to each other and producing Moiré lattice. Another outstanding property of inorganic layer compounds is their tendency to form nanotubes, reported first (for WS<sub>2</sub>) many years ago and subsequently from many other layered compounds.Among the 2D-materials, misfit layer compounds make a special class with an incommensurate and nonstoichiometric lattice made of an alternating layer with rocksalt structure, like LaS (<i>O</i>) and a layer with hexagonal structure, like TaS<sub>2</sub> (<i>T</i>). The lack of lattice commensuration between the two slabs leads to a built-in strain, which can be relaxed via bending. Consequently, nanotubes have been produced from numerous MLC compounds over the past decade and their structure was elucidated.Owing to their large surface area, nanostructures are generally metastable and tend to recrystallize into microscopic crystallites via different mechanisms, like Ostwald ripening, or chemically decompose and then recrystallize. The stability of nanostructures at elevated temperatures has been investigated quite scarcely so far. In this perspective, electron microscopy as well as synchrotron-based X-ray absorption and reflection techniques were used to elucidate the chemical selectivity and decomposition routes of rare-earth based MLC nanotubes prepared at elevated temperatures (800-1200 °C).As for the chemical selectivity, entropic effects are expected to dictate the random distribution of the chalcogen atoms on the anion sites of the MLC nanotubes at elevated temperatures. Nonetheless, the sulfur atoms were found to bind exclusively to the rare-earth atom (Ln = La, Sm) of the rocksalt slab and the selenium to the tantalum of the hexagonal TX<sub>2</sub> slab. This uncommon selectivity was not found in other kinds of nanotubes like WSe<sub>2<i>x</i></sub>S<sub>2(1-<i>x</i>)</sub>. In other series of experiments, the lack of utter symmetry in the multiwall nanotubes leads to exclusions of certain X-ray (0<i>kl</i>) reflections, which was used to distinguish them from the bulk crystallites. The transformation of Ln-based MLC nanotubes into microscopic flakes was followed as a function of the synthesis temperature (800-1200 °C) and the synthesis time (1-96 h). Furthermore, sequential h","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":" ","pages":"3243-3253"},"PeriodicalIF":19.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface Structure and Chemistry of CeO₂ Powder Catalysts Determined by Surface-Ligand Infrared Spectroscopy (SLIR).","authors":"Chengwu Yang, Hicham Idriss, Yuemin Wang, Christof Wöll","doi":"10.1021/acs.accounts.4c00529","DOIUrl":"10.1021/acs.accounts.4c00529","url":null,"abstract":"<p><p>ConspectusCerium is the most abundant rare earth element in the Earth's crust. Its most stable oxide, cerium dioxide (CeO<sub>2</sub>, ceria), is increasingly utilized in the field of catalysis. It can catalyze redox and acid-base reactions, and serve as a component of electrocatalysts and even photocatalysts. As one of the most commonly used in situ/operando characterization methods in catalysis, infrared (IR) spectroscopy is routinely employed to monitor reaction intermediates on the surface of solid catalysts, offering profound insight into reaction mechanisms. Additionally, IR vibrational frequencies of probe molecules adsorbed on solid catalysts provide detailed information about their structure and chemical states. Numerous studies in the literature have utilized carbon monoxide and methanol as IR probe molecules on ceria particles. However, assigning their vibrational frequencies is often highly controversial due to the great complexity of the actual surface of ceria particles, which include differently oriented crystal facets, reconstructions, defects, and other structural variations. In our laboratory, taking bulk ceria single crystals with distinct orientations as model systems, we employed a highly sensitive ultrahigh vacuum (UHV) infrared spectroscopy system (THEO) to study the adsorption of CO and methanol. It turns out that the theoretical calculations adopting hybrid functionals (HSE06) can bring the theoretical predictions into agreement with the experimental results for the CO frequencies on ceria single crystal surfaces. The obtained frequencies serve as reliable references to resolve the long-standing controversial assignments for the IR bands of CO and methanol adsorbed on ceria particles. Furthermore, these characteristic frequencies allow for the determination of orientations, oxidation states and restructuring of exposed crystal facets of ceria nanoparticles, which is applicable from UHV conditions to industrially relevant pressures of up to 1 bar, and from low temperatures (∼65 K) to high temperatures (∼1000 K). We also used molecular oxygen as a probe molecule to investigate its interaction with the ceria surface, crucial for understanding ceria's redox properties. Our findings reveal that the localization of oxygen vacancies and the mechanism of dioxygen activation are highly sensitive to surface orientations. We provided the first spectroscopic evidence showing that the oxygen vacancies on ceria (111) surfaces tend to localize in deep layers. In addition, we employed N<sub>2</sub>O as a probe molecule to elucidate the origin of the photocatalytic activity of ceria and showed that the photocatalytic activity is highly sensitive to the surface orientation (i.e., surface coordination structure). This Account shows that probe-molecule infrared spectroscopy serves as a powerful in situ/operando tool for studying the surface structure and chemistry of solid catalysts, and the knowledge gained through the \"Surface Scienc","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":" ","pages":"3316-3326"},"PeriodicalIF":19.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Exploitation, and Rational Improvements of Diazirine-Based Universal Polymer Crosslinkers.","authors":"Mathieu L Lepage, Stefania F Musolino, Jeremy E Wulff","doi":"10.1021/acs.accounts.4c00509","DOIUrl":"10.1021/acs.accounts.4c00509","url":null,"abstract":"<p><p>ConspectusAddition of new covalent bonds between the chains of thermoplastic polymers (i.e., crosslinking) provides improved mechanical strength and enhanced high-temperature performance while also providing an effective strategy for photopatterning. Traditionally, however, crosslinking of each polymer substrate has required the use of a specific crosslinking technology (hydrosilylation for PDMS, vulcanization for rubber, etc.). The lack of a general solution to the challenge of polymer crosslinking means that there are many thermoplastics (e.g., polypropylene or polyhydroxyalkanoates) that have desirable properties, but which cannot be upgraded by traditional crosslinking technologies.Our lab developed the first universal crosslinkers for aliphatic polymers by leveraging trifluoromethyl aryl diazirine motifs, functional groups that have been widely used in chemical biology for >30 years, but which have seldom been exploited in materials science. These novel reagents work (via C-H insertion) on essentially any commodity polymer that contains aliphatic C-H bonds, including industrial plastics like polypropylene (the crosslinking of which has been an outstanding challenge in the field for >50 years), as well as commercially important elastomers (e.g., polydimethylsiloxane), biodegradable polymers (e.g., polycaprolactone), and green polymer materials derived from biomass (e.g., polyhydroxyalkanoates).Subsequent structure-function work from our group led to crosslinkers that were >10-fold more effective in undergoing C-H insertion with aliphatic substrates. We then developed an improved synthesis of our electronically optimized diazirines and incorporated them into a family of cleavable crosslinker reagents, which permit the on-demand generation of reprocessable thermosets. At the same time, other groups replaced the perfluoropropyl linker in our first-generation crosslinker with a series of dynamic linkages; these permit the ready generation of vitrimeric materials and can be used in the reactive compatibilization of immiscible plastic waste.Since the publication of our initial <i>Science</i> paper in 2019, this burgeoning field of diazirine-based polymer crosslinkers has experienced an explosion of interest. Publications from our lab and others have described the use of these reagents in covalent adhesion, photopatterning of low dielectric materials for microelectronics, and direct optical printing of quantum dots. Our crosslinkers have also been shown to heighten the robustness of ice-phobic coatings and improve the performance of woven ballistic fabric, while─perhaps most unexpectedly─substantially improving the stability of high-performance perovskite solar cells. Electronically optimized diazirines can also be used to covalently link proteins to polymer surfaces, suggesting a broad range of applications in the biocompatibilization of medical devices. This Account will summarize the development of trifluoromethyl aryl diazirine reagents fo","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":" ","pages":"3327-3342"},"PeriodicalIF":19.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detrimental Defect Cooperativity at TiO2/CH3NH3PbI3 Interface: Decreased Stability, Enhanced Ion Diffusion, and Reduced Charge Lifetime and Transport","authors":"Kai-Ping Wang, Zhi-Wei Wu, Kai-Feng Wang, Hao-Ting Xu, Jun He, Bo Wen, Chuan-Jia Tong, Li-Min Liu, Oleg V. Prezhdo","doi":"10.1021/acsenergylett.4c02587","DOIUrl":"https://doi.org/10.1021/acsenergylett.4c02587","url":null,"abstract":"Interfaces are essential for solar cell performance since they govern charge separation and transport. Using quantum dynamics simulation, we demonstrate that at interfaces, common defects that are benign on their own, iodine vacancy in CH₃NH₃PbI₃ (V_I) and oxygen vacancy in TiO₂ (V_O), are responsible synergistically for poor stability and charge losses. V_O promotes V_I diffusion and accelerates iodine migration. A midgap trap state appears, inhibiting charge transport and accelerating charge recombination by an order of magnitude. Strong structural distortions strengthen electron-vibrational interactions and activate high-frequency TiO₂ phonons. Because of the widely reported high defect-tolerance of lead-halide perovskites, the synergistic detrimental influence of perovskite defects with defects in other materials is often overlooked. The interfacial defect pairing could be a major reason for poor stability and charge losses in perovskite solar cells. The results suggest that either a high-quality perovskite or high-quality charge extraction layer may be sufficient to achieve high performance.","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":"112 1","pages":""},"PeriodicalIF":22.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial Decoupling Layer Enabled Low-n Phase Enrichment for Blue Quasi-2D Perovskites","authors":"Jie Dong, Wenqiang Yang, Kayoung Cho, Jeong Hyun Jung, Huanyu Zhou, Eojin Yoon, Hao Chen, Hyeon-Dong Lee, Seung Hyeon Jo, Jae-Man Park, Qingsen Zeng, Tingyu Long, Kyung Yeon Jang, Seong Eui Chang, Chan-Yul Park, Min-Jun Sung, Joo Sung Kim, Hyeree Kim, Dandan Song, Zheng Xu, JaeHong Park, Jeong-Yun Sun, Tae-Woo Lee","doi":"10.1021/acsenergylett.4c02351","DOIUrl":"https://doi.org/10.1021/acsenergylett.4c02351","url":null,"abstract":"The random <i>n</i>-monolayer phase distributions and impurity phases impose challenges to achieving blue-emission quasi-2D perovskite light emitting diodes (PeLEDs), and their formation mechanism is unclear. Here, we uncover the reasons behind the phase formation and distribution in blue-emission quasi-2D perovskites by probing into the molecular interactions at the buried interface between substrates and perovskites and propose a mechanistic model to depict the film formation process. Furthermore, an interfacial decoupling layer, perfluorinated ionomer, was employed to successfully mitigate the negative impact of substrates on the phase formation and distribution of blue-emission quasi-2D perovskites, resulting in an ordered phase distribution and a reduction of undesired phases. Besides, this interfacial layer effectively suppressed the nonradiative recombination losses, leading to enhanced photoluminescence quantum yield from 12.71% to 60.13% and notable blue shift (∼10 nm) even without incorporating Cl ions. As a result, blue PeLEDs based on this strategy achieved an external quantum efficiency reaching 12.09%.","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":"10 1","pages":""},"PeriodicalIF":22.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Photoexcitations Probed by Multipulse Photoluminescence","authors":"Alexandr Marunchenko, Jitendra Kumar, Dmitry Tatarinov, Anatoly P. Pushkarev, Yana Vaynzof, Ivan G. Scheblykin","doi":"10.1021/acsenergylett.4c02404","DOIUrl":"https://doi.org/10.1021/acsenergylett.4c02404","url":null,"abstract":"Time-resolved photoluminescence is a validated method for tracking the photoexcited carrier dynamics in luminescent materials. This technique probes the photoluminescence decays upon a periodic excitation by short laser pulses. Herein, we show that this approach cannot directly detect hidden photoexcitations with much slower dynamics than the photoluminescence decay. We demonstrate a new method based on a multipulse excitation scheme that enables an unambiguous detection and an easily interpreted tracking of these hidden species. The multipulse excitation consists of a single pulse (Read) followed by a burst of many closely separated pulses (Write) and finally another single pulse (Read). To illustrate the efficacy of the Read-Write-Read excitation scheme, we apply it to metal halide perovskites to directly visualize carrier trapping, extract the concentration of trapped charges, and determine the rate constant of trap depopulation. The developed approach allows studying performance-limiting processes in energy devices using a versatile, highly applicable all-optical method.","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":"225 1","pages":""},"PeriodicalIF":22.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the expanded label for elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis with no F508del variant in the USA.","authors":"Elizabeth A Cromwell, Josh S Ostrenga, Don B Sanders, Wayne Morgan, Carlo Castellani, Rhonda Szczesniak, Pierre-Regis Burgel","doi":"10.1183/13993003.01146-2024","DOIUrl":"10.1183/13993003.01146-2024","url":null,"abstract":"<p><strong>Background: </strong>Elexacaftor/tezacaftor/ivacaftor (ETI), which is approved for people with cystic fibrosis (pwCF) with a F508del variant, was further approved based on <i>in vitro</i> data in the USA for those carrying at least one of 177 rare <i>CFTR</i> (cystic fibrosis transmembrane conductance regulator) variants.</p><p><strong>Methods: </strong>PwCF, aged ≥6 years, carrying no F508del variant but with at least one of these 177 rare variants, were identified within the US Cystic Fibrosis Foundation Patient Registry (CFFPR) between 2020 and 2022. The evolution of forced expiratory volume in 1 s (FEV₁) percentage predicted and rates of pulmonary exacerbations were analysed over the first year following ETI initiation, using a linear regression with generalised estimating equations and a negative binomial model, respectively.</p><p><strong>Results: </strong>A total of 1791 individuals aged ≥6 years with rare <i>CFTR</i> variants were eligible for ETI, corresponding to 5.2% of CFFPR participants. 815 individuals (45.5%), of which 57.9% were already treated with another CFTR modulator, initiated ETI within the first 2 years following approval. Individuals with more severe respiratory disease were more likely to initiate ETI, whereas those previously treated with another CFTR modulator or those with no private insurance coverage had less ETI initiation. ETI initiation was associated with an increase in mean FEV₁ % pred by +3.39 (95% CI 2.14-4.64) and a decrease in the rates of pulmonary exacerbations (adjusted rate ratio 0.55, 95% CI 0.38-0.79). These effects were greater in individuals naïve of previous CFTR modulators.</p><p><strong>Conclusions: </strong>Extension of the ETI label to rare <i>CFTR</i> variants is associated with meaningful improvements in lung function and a marked reduction in pulmonary exacerbations.</p>","PeriodicalId":16,"journal":{"name":"ACS Energy Letters ","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}