Biomacromolecules最新文献

Phosphorylcholine Polymer Conjugation Improves the Pharmaceutical Performance of Protein Therapeutics. 磷酸胆碱聚合物偶联提高蛋白质治疗的药物性能。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-13 DOI: 10.1021/acs.biomac.5c00253

Jie Ren, Amin Haghighat Naeini, Nishant Kumar, Ming Zhao

{"title":"Phosphorylcholine Polymer Conjugation Improves the Pharmaceutical Performance of Protein Therapeutics.","authors":"Jie Ren, Amin Haghighat Naeini, Nishant Kumar, Ming Zhao","doi":"10.1021/acs.biomac.5c00253","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00253","url":null,"abstract":"Proteins hold significant potential for the treatment of various diseases. However, challenges such as immunogenicity and limited in vivo resident time hinder their clinical translation. This study introduces thiol-maleimide click chemistry to achieve controlled polymer-protein conjugation. Poly(2-methacryloyloxyethyl phosphorylcholine)-uricase (PMPC-UOX) conjugates with three distinct polymer chain lengths were prepared, and their in vitro and in vivo performances were compared. Owing to the antifouling properties of PMPC polymers, the conjugates exhibited chain length-dependent performance. A longer PMPC polymer chain in the conjugate resulted in a greater reduction in immunological phagocytosis, a prolonged plasma half-life, lower immunogenicity, and improved therapeutic outcomes compared to both the native protein and conjugates with shorter polymer chains. This study elucidates the interplay between the zwitterionic polymer chain length and the in vivo pharmaceutical performance of protein therapeutics, enabling precise control of zwitterionic polymer modification to achieve optimal outcomes. Furthermore, we envision that this protein modification platform can be retooled to deliver a plethora of protein therapeutics.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Strawberry-Structured Micro/Nano Fibers as Positive Friction Layers for High-Performance Triboelectric Nanogenerators. 仿生草莓结构微纳米纤维作为高性能摩擦电纳米发电机的正摩擦层。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-12 DOI: 10.1021/acs.biomac.5c01403

Chenglei Ru, Jing Yin, Lan Xu

引用次数: 0

Investigating the Biocompatibility and Functionality of Acetylsalicylic Acid-Loaded GumMA Inks for the Application of Cardiovascular Grafts: Local Antithrombotic Drug Delivery Platform. 研究载乙酰水杨酸GumMA墨水在心血管移植中的生物相容性和功能：局部抗血栓药物传递平台。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-12 DOI: 10.1021/acs.biomac.5c00512

Burcin Izbudak, Samin Dastjerd, Mustafa Donmez, Banu Kocaaga, Fatma Seniha Guner, Ayca Bal-Ozturk

{"title":"Investigating the Biocompatibility and Functionality of Acetylsalicylic Acid-Loaded GumMA Inks for the Application of Cardiovascular Grafts: Local Antithrombotic Drug Delivery Platform.","authors":"Burcin Izbudak, Samin Dastjerd, Mustafa Donmez, Banu Kocaaga, Fatma Seniha Guner, Ayca Bal-Ozturk","doi":"10.1021/acs.biomac.5c00512","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00512","url":null,"abstract":"The current study aims to provide new solutions in cardiovascular tissue engineering through formulating methacrylated gellan gum (GumMA)-based hydrogel grafts with respect to 2, 3, and 3.5% polymer contents while incorporating acetylsalicylic acid (ASA) as an antithrombotic agent, tailored through three-dimensional (3D) bioprinting technique and photo-cross-linking with Irgacure 2959 under UV to enhance mechanical features, biocompatibility, and therapeutic efficacy. The investigation assessed GumMA's concentration impact on physicochemical characteristics and in vitro biological performance of the hydrogels, in which the results revealed that the swelling ratio decreased by increasing the polymer content while maintaining structural stability over time in phosphate-buffered saline (PBS) and simulated body fluid (SBF) mediums that contributed to the observed ASA biphasic release profile. Furthermore, the system exhibited excellent hemocompatibility and nontoxicity toward human umbilical vein endothelial cells (HUVEC), and its hemostatic capacity was investigated through hemolysis and coagulation analysis. Based on these findings, the developed grafts are promising candidates for use as bioengineered vascular grafts with a long-term functional performance.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Limits of Passive Macromolecular Translocation through Phospholipid Membranes. 探索通过磷脂膜进行被动大分子易位的极限。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-12 DOI: 10.1021/acs.biomac.5c01234

Ekaterina Kostyurina, Ralf Biehl, Margarita Kruteva, Alexandros Koutsioubas, Henrich Frielinghaus, Nageshwar Rao Yepuri, Stephan Förster, Jürgen Allgaier

{"title":"Exploring the Limits of Passive Macromolecular Translocation through Phospholipid Membranes.","authors":"Ekaterina Kostyurina, Ralf Biehl, Margarita Kruteva, Alexandros Koutsioubas, Henrich Frielinghaus, Nageshwar Rao Yepuri, Stephan Förster, Jürgen Allgaier","doi":"10.1021/acs.biomac.5c01234","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01234","url":null,"abstract":"Transportation of active macromolecules through cell membranes is an essential biological process. However, for hydrophilic macromolecules, the hydrophobic interior of lipid bilayers suppresses the passive translocation, and there are only few cases reported. We use alternating amphiphilic polymers (AAPs) in which the sizes of the hydrophilic and hydrophobic units can be varied over a broad range, keeping the polymers water-soluble. For small units, the macromolecules show a homopolymer-like character. Pulse field gradient NMR and neutron reflectivity measurements show that the chains have a high solubility in the membrane hydrophobic interior that allows the chains to passively translocate. Increasing the length of the hydrophilic units leads to more polar AAPs with low membrane solubility and a reduced translocation speed. If hydrophilic and hydrophobic moieties are increased in size, the AAPs have a strong amphiphilic character and adsorb to lipid membranes only with their hydrophobic units, have a high membrane concentration, and have an overall fast translocation kinetics.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naphthalene-Derived Polynorbornenes Nanoaggregates for the Selective and Sensitive Detection of Hydrogen Sulfide in Environmental and Biological Samples. 萘衍生聚降冰片烯纳米聚集体用于环境和生物样品中硫化氢的选择性和敏感检测。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-11 DOI: 10.1021/acs.biomac.5c00711

Jyotirlata Singha, Tapendu Samanta, Narayan Das, Srishti Gautam, Nusrath Fathima, Diptendu Patra, Pawan Kumar, Raja Shunmugam

{"title":"Naphthalene-Derived Polynorbornenes Nanoaggregates for the Selective and Sensitive Detection of Hydrogen Sulfide in Environmental and Biological Samples.","authors":"Jyotirlata Singha, Tapendu Samanta, Narayan Das, Srishti Gautam, Nusrath Fathima, Diptendu Patra, Pawan Kumar, Raja Shunmugam","doi":"10.1021/acs.biomac.5c00711","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00711","url":null,"abstract":"H2S is a very rapidly acting, highly toxic gas that can produce rapid CNS and respiratory depression. A polyethylene-glycol-incorporated polymeric sensor (NNAP-peg-P) has been shown to have a rapid detection ability for H2S in the pure aqueous medium, where the monomeric sensor (NNAPM) shows H2S detection in (1:1) DMSO-H2O solvent medium (in PBS buffer pH 7.4) and outputs a yellowish fluorescence turn-on signal at 533 nm. Both NNAPM and NNAP-Peg-P show a specific fluorescence response toward H2S over anions, biothiols, and other amino acids in a neutral environment. NNAP-peg-P is exploited effectively for intracellular H2S detection and imaging through fluorescence microscopy, as it has no apparent cell toxicity and good membrane permeability. Its utility for imaging of H2S in living HeLa cells has been documented. NAP-peg-P has been used to prepare a paper strip for the in-field detection of H2S.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen-Generating Bioscaffold for the Treatment of Skin Anaerobic Infections. 产氧生物支架治疗皮肤厌氧感染。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-11 DOI: 10.1021/acs.biomac.5c00591

Min Ru, Renyan Huang, Lu Wang, Zuwei Luo, Ying Huang, Renchuan You, Ruoxuan Peng, Shuqin Yan, Qiang Zhang, Shengjie Ling, Weilin Xu

{"title":"Oxygen-Generating Bioscaffold for the Treatment of Skin Anaerobic Infections.","authors":"Min Ru, Renyan Huang, Lu Wang, Zuwei Luo, Ying Huang, Renchuan You, Ruoxuan Peng, Shuqin Yan, Qiang Zhang, Shengjie Ling, Weilin Xu","doi":"10.1021/acs.biomac.5c00591","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00591","url":null,"abstract":"In response to the difficulties posed by anaerobic bacterial infections in wound healing, particularly in light of the increasing prevalence of antibiotic-resistant strains and the complex nature of wound environments, this study introduces a meticulously planned oxygen-generating tissue engineering scaffold to address these obstacles. This scaffold is realized from silk fibroin (SF), poly(vinyl alcohol) (PVA), and calcium peroxide (CPO) by ice crystal-induced self-assembly combined with the ice template method, aiming at a synergistic balance of hydrophilicity, structural stability, mechanocompatibility with biological tissues, controllable oxygen-releasing behavior, and antianaerobic bacterial properties. In particular, the oxygen-generating scaffold containing 2.5% CPO exhibits excellent antianaerobic properties by destroying C. perfringens through a mechanism that disrupts bacterial cell membranes and DNA, as well as promotes the generation of reactive oxygen species. Meanwhile, significant cytotoxic or hemolytic effects were avoided. Subsequent results demonstrated that the oxygen-generating scaffold accelerated the healing process of C. perfringens-infected wounds with results similar to those of amoxicillin. These results emphasize the promise of this new platform in clinical practice for the treatment of anaerobic bacterial infections and establishing a basis for advanced therapeutic strategies.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water-Activated Degradable Supramolecular Bioadhesive Powder for Underwater Tissue Adhesion and Wound Healing. 用于水下组织黏附和伤口愈合的水活化可降解超分子生物黏附粉。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-11 DOI: 10.1021/acs.biomac.5c01057

Hongjian Huang, Zongxuan Huang, Shuichang Chen, Xiaoyu Yang, Hu Zhao, Qinhui Chen, Haiqing Liu

{"title":"Water-Activated Degradable Supramolecular Bioadhesive Powder for Underwater Tissue Adhesion and Wound Healing.","authors":"Hongjian Huang, Zongxuan Huang, Shuichang Chen, Xiaoyu Yang, Hu Zhao, Qinhui Chen, Haiqing Liu","doi":"10.1021/acs.biomac.5c01057","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01057","url":null,"abstract":"Traditional suturing and stapling demand surgical skill and risk additional trauma, whereas conventional tissue adhesives falter on wet surfaces. Inspired by cement curing, a water-activated bioadhesive powder (WABP) was developed in this work. WABP was a mixture of tannic acid-terminated poly(lipoic acid) (TA-PLA) and arginine (Arg), in which the TA-PLA was synthesized through the Michael addition reaction of PLA containing disulfide radicals with TA possessing a radical quenching effect. Upon hydration, the powder swiftly formed a self-assembled coacervate adhesive, which exhibited antiswelling properties in underwater environments, a result of the combined effects of hydrogen bonding, electrostatic interactions, and hydrophobic associations. The WABP, harnessing the attributes of both powder and coacervate adhesives, was adept at conforming to an irregular wound shape and delivered stable bioadhesive performance. It demonstrated superior wound healing capabilities, antibacterial properties, favorable cytocompatibility, and histocompatibility. This supramolecular WABP offers a simple, multifunctional alternative to sutures for biomedical applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amphiphilic Poly(SBMA-co-EGDEA) Coatings for Marine Antifouling: Insights into Design Criteria for Hydrophobic Monomers. 海洋防污用两亲聚（SBMA-co-EGDEA）涂料：疏水单体设计标准的见解。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-10 DOI: 10.1021/acs.biomac.5c00875

Jinhyeok Jeong, Jinwoo Lee, Sang Uk Jeong, Jae Woo Park, Sung Min Kang

{"title":"Amphiphilic Poly(SBMA-co-EGDEA) Coatings for Marine Antifouling: Insights into Design Criteria for Hydrophobic Monomers.","authors":"Jinhyeok Jeong, Jinwoo Lee, Sang Uk Jeong, Jae Woo Park, Sung Min Kang","doi":"10.1021/acs.biomac.5c00875","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00875","url":null,"abstract":"Marine biofouling poses significant economic and environmental challenges, highlighting the need for effective antifouling coatings. We report amphiphilic poly(SBMA-co-EGDEA) copolymer coatings that resist both marine diatom adhesion and sediment adsorption. The coatings were synthesized via surface-initiated ATRP and RAFT polymerization using hydrophilic sulfobetaine methacrylate (SBMA) and hydrophobic ethylene glycol dicyclopentenyl ether acrylate (EGDEA). Interestingly, EGDEA exhibited a partial negative charge when coated on a surface, as confirmed by computational analyses. Since marine sediments are typically negatively charged and adhere strongly to hydrophilic surfaces, EGDEA's combination of hydrophobicity and negative charge effectively minimized sediment adsorption while maintaining resistance to diatom adhesion. Experimental results further showed that coatings with higher EGDEA content exhibited superior antifouling performance. These findings highlight the unique role of EGDEA in amphiphilic copolymers and provide valuable design insights for next-generation marine antifouling coatings.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Subcutaneous Implantable Microneedle System for the Treatment of Alzheimer's Disease by Delivering Donepezil". 更正“用多奈哌齐皮下植入微针系统治疗阿尔茨海默病”。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-09 DOI: 10.1021/acs.biomac.5c01588

Ze Qiang Zhao, Ling Liang, Liu Fu Hu, Yu Ting He, Li Yue Jing, Yue Liu, Bo Zhi Chen, Xin Dong Guo

引用次数: 0

Effect of C-Terminal Residue on the Phase Behavior and Properties of β-Sheet Forming Self-Assembling Peptide Hydrogels. c端残基对β-片状自组装肽水凝胶相行为和性质的影响。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-09-09 DOI: 10.1021/acs.biomac.5c01348

Nastaran Zoghi, Chao-Yu Yang, Richard Bryce, Aline F Miller, Alberto Saiani

{"title":"Effect of C-Terminal Residue on the Phase Behavior and Properties of β-Sheet Forming Self-Assembling Peptide Hydrogels.","authors":"Nastaran Zoghi, Chao-Yu Yang, Richard Bryce, Aline F Miller, Alberto Saiani","doi":"10.1021/acs.biomac.5c01348","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01348","url":null,"abstract":"This study investigates how hydrophobic and hydrophilic modifications at the C-terminus of the base peptide, KFEFEFKFK (KbpK), affect the hydrogel macroscopic properties. By the incorporation of phenylalanine (F, hydrophobic) and lysine (K, hydrophilic) residues, four variants, KbpK-K, KbpK-F, KbpK-KF, and KbpK-FK, were designed and evaluated. pH-concentration phase diagrams and Fourier transform infrared confirmed clear links showing how peptide hydrophobicity and charge influence β-sheet formation and macroscopic phase behavior. Hydrophobic modifications enhanced β-sheet formation, promoting denser fiber networks and stable gelation across a broad pH range, while hydrophilic modification reduced lateral association and gelation strength. Transmission electron microscopy and small-angle X-ray scattering revealed consistent fiber diameters and confirmed stronger self-assembly with increasing hydrophobicity. Rheological analysis showed that all samples exhibit viscoelastic, shear-thinning behavior with higher storage moduli observed for more hydrophobic peptides. These findings demonstrate how subtle peptide modifications modulate fiber assembly, network architecture, and hydrogel mechanics, enabling the design of tunable, injectable peptide-based hydrogels for biomedical applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0