Biomacromolecules最新文献

Lifting the minority tax in gastroenterology and hepatology. 取消胃肠病学和肝病学中的少数民族税。

IF 30.9 2区化学

Biomacromolecules Pub Date : 2024-12-01 Epub Date: 2024-09-14 DOI: 10.1016/S2468-1253(24)00268-1

Sophie M Balzora

引用次数: 0

Single-Step Synthesis of Highly Sensitive ¹⁹F MRI Tracers by Gradient Copolymerization-Induced Self-Assembly. 通过梯度共聚诱导自组装一步合成高灵敏度 19F MRI 示踪剂。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-18 DOI: 10.1021/acs.biomac.4c00915

Vyshakh M Panakkal, Dominik Havlicek, Ewa Pavlova, Klara Jirakova, Daniel Jirak, Ondrej Sedlacek

{"title":"Single-Step Synthesis of Highly Sensitive 19F MRI Tracers by Gradient Copolymerization-Induced Self-Assembly.","authors":"Vyshakh M Panakkal, Dominik Havlicek, Ewa Pavlova, Klara Jirakova, Daniel Jirak, Ondrej Sedlacek","doi":"10.1021/acs.biomac.4c00915","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00915","url":null,"abstract":"Amphiphilic gradient copolymers are promising alternatives to block copolymers for self-assembled nanomaterials due to their straightforward synthesis via statistical copolymerization of monomers with different reactivities and hydrophilicity. By carefully selecting monomers, nanoparticles can be synthesized in a single step through gradient copolymerization-induced self-assembly (gPISA). We synthesized highly sensitive 19F MRI nanotracers via aqueous dispersion gPISA of hydrophilic poly(ethylene glycol) methyl ether methacrylate (PEGMA) with core-forming N,N-(2,2,2-trifluoroethyl)acrylamide (TFEAM). The PPEGMA-grad-PTFEAM nanoparticles were optimized to achieve spherical morphology and exceptional 19F MRI performance. Noncytotoxicity was confirmed in Panc-1 cells. In vitro 19F MR relaxometry and imaging demonstrated their diagnostic imaging potential. Notably, these gradient copolymer nanotracers outperformed block copolymer analogs in 19F MRI performance due to their gradient architecture, enhancing 19F relaxivity. The synthetic versatility and superior 19F MRI performance of gradient copolymers highlight their potential in advanced diagnostic imaging applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogels Based on Polyelectrolyte Complexes: Underlying Principles and Biomedical Applications. 基于聚电解质复合物的水凝胶：基本原理和生物医学应用。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-18 DOI: 10.1021/acs.biomac.4c01240

Belynn Sim, Jun Jie Chang, Qianyu Lin, Joey Hui Min Wong, Valerie Ow, Yihao Leow, Yi Jing Wong, Yi Jian Boo, Rubayn Goh, Xian Jun Loh

{"title":"Hydrogels Based on Polyelectrolyte Complexes: Underlying Principles and Biomedical Applications.","authors":"Belynn Sim, Jun Jie Chang, Qianyu Lin, Joey Hui Min Wong, Valerie Ow, Yihao Leow, Yi Jing Wong, Yi Jian Boo, Rubayn Goh, Xian Jun Loh","doi":"10.1021/acs.biomac.4c01240","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01240","url":null,"abstract":"Ionic complexes of electrostatically charged biomacromolecules are key players in various biological processes like nucleotide transportation, organelle formation, and protein folding. These complexes, abundant in biological systems, contribute to the function, responsiveness, and mechanical properties of organisms. Coherent with these natural phenomena, hydrogels formed through the complexation of oppositely charged polymers exhibit unique attributes, such as rapid self-assembly, hierarchical microstructures, tunable properties, and protective encapsulation. Consequently, polyelectrolyte complex (PEC) hydrogels have garnered considerable interest, emerging as an up-and-coming platform for various biomedical applications. This review outlines the underlying principles governing PEC hydrogels. The classification of polyelectrolytes and the self-assembly of PEC hydrogels are discussed, including the factors influencing their self-assembly process. Recent developments of PEC hydrogels for biomedical applications, including drug delivery, tissue engineering, wound healing and management, and wearable sensors, are summarized. This review concludes with the prospective directions for the next generation of PEC hydrogel research.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Improved Redispersibility of Cellulose Nanocrystals Using Hydroxypropyl Cellulose and Structure Color from Redispersed Cellulose Nanocrystals. 利用羟丙基纤维素改善纤维素纳米晶体的再分散性以及再分散纤维素纳米晶体的结构色。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-15 DOI: 10.1021/acs.biomac.4c01277

Huan Wang, Lukuan Guo, Mingfeng Wu, Guang Chu, Wenyuan Zhu, Junlong Song, Jiaqi Guo

{"title":"The Improved Redispersibility of Cellulose Nanocrystals Using Hydroxypropyl Cellulose and Structure Color from Redispersed Cellulose Nanocrystals.","authors":"Huan Wang, Lukuan Guo, Mingfeng Wu, Guang Chu, Wenyuan Zhu, Junlong Song, Jiaqi Guo","doi":"10.1021/acs.biomac.4c01277","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01277","url":null,"abstract":"Cellulose nanocrystals (CNC) have been significantly developed as a building block material for the design of novel functional materials in many fields such as biomedicine, nanotechnology, and materials science due to their excellent optical properties, biocompatibility, and sustainability. Improving the redispersibility of CNC in the sustainable processing of nanocellulose has been a challenge because intense hydrogen bond interaction leads to irreversible aggregation, making CNC difficult to redisperse and increasing the cost of storage and transportation of CNC. Hydroxypropyl cellulose (HPC) is an important hydroxy propylated cellulose ether. As a water-soluble cellulose derivative, HPC has a polyhydroxy structure similar to that of CNC, which leads to good compatibility and high affinity between HPC and CNC. In this work, HPC of different molecular weights was comixed with CNC of different contents, which was then dried using different methods, and the dried samples were redispersed in water. The addition of HPC improved the redispersibility of the CNC. Finally, the redispersed suspension was also redried to form a film, which was found to retain its structure color. These results provide an important avenue for the redispersion of dried CNC and for the development of functional materials from redispersed CNC.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adhesive, Stretchable, and Photothermal Antibacterial Hydrogel Dressings for Wound Healing of Infected Skin Burn at Joints. 用于关节感染性皮肤烧伤伤口愈合的粘性、可伸缩和光热抗菌水凝胶敷料。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-14 DOI: 10.1021/acs.biomac.4c01023

Chen Zhang, Hua Zhao, Shanshan Geng, Chenghao Li, Jingmei Liu, Yuxin Chen, Ming Yi, Yuntong Liu, Fangxia Guan, Minghao Yao

引用次数: 0

Chitosan-Promoted TiO₂-Loaded Double-Network Hydrogels for Dye Removal and Wearable Sensors. 壳聚糖促进的 TiO2 负载双网水凝胶用于染料去除和可穿戴传感器。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-14 DOI: 10.1021/acs.biomac.4c01286

Wei Gao, Huichun Kang, Ming Zhong, Lijuan Han, Xue Guo, Bitao Su, Ziqiang Lei

{"title":"Chitosan-Promoted TiO2-Loaded Double-Network Hydrogels for Dye Removal and Wearable Sensors.","authors":"Wei Gao, Huichun Kang, Ming Zhong, Lijuan Han, Xue Guo, Bitao Su, Ziqiang Lei","doi":"10.1021/acs.biomac.4c01286","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01286","url":null,"abstract":"The loading of photocatalysts on hydrogels can significantly reduce the loss of catalysts and effectively prevent secondary contamination, thus demonstrating great application potential and advantages in the field of wastewater treatment, especially in the removal of dyes. Herein, the semiconductor TiO2 was successfully loaded into a polyacrylic acid/chitosan (PAA/CS) double-network (DN) hydrogel, which exhibited superior removal of dyes in wastewater such as MG, MB, MV, and RhB. The dye degradation process followed first-order kinetics, and the first-order rate constants for dye degradation were further calculated under UV light irradiation. Furthermore, the photocatalytic mechanism of the hydrogel was explored and analyzed. More interestingly, the PAA/CS-TiO2 DN hydrogel has excellent tensile properties and superior electrical conductivity, which can be assembled into flexible sensors for real-time monitoring of mechanical deformations and human joint motions. It is envisioned that these excellent properties make hydrogel photocatalysts promising for a wide range of applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Healing, Electrically Conductive, Antibacterial, and Adhesive Eutectogel Containing Polymerizable Deep Eutectic Solvent for Human Motion Sensing and Wound Healing. 自愈性、导电性、抗菌性和粘性共晶凝胶，含有可聚合的深共晶溶剂，用于人体运动传感和伤口愈合。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-14 DOI: 10.1021/acs.biomac.4c00960

Shaghayegh Vakili, Zahra Mohamadnia, Ebrahim Ahmadi

{"title":"Self-Healing, Electrically Conductive, Antibacterial, and Adhesive Eutectogel Containing Polymerizable Deep Eutectic Solvent for Human Motion Sensing and Wound Healing.","authors":"Shaghayegh Vakili, Zahra Mohamadnia, Ebrahim Ahmadi","doi":"10.1021/acs.biomac.4c00960","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00960","url":null,"abstract":"Flexible electronic devices such as wearable sensors are essential to advance human-machine interactions. Conductive eutectogels are promising for wearable sensors, despite their challenges in self-healing and adhesion properties. This study introduces a multifunctional eutectogel based on a novel polymerizable deep eutectic solvent (PDES) prepared by the incorporation of diallyldimethylammonium chloride (DADMAC) and glycerol in the presence of polycyclodextrin (PCD)/dopamine-grafted gelatin (Gel-DOP)/oxidized sodium alginate (OSA). The synthesized eutectogel has reversible Schiff-base bonds, hydrogen bonds, and host-guest interactions, which enable rapid self-healing upon network disruption. GPDO-15 eutectogel has significant tissue adhesion, high stretchability (419%), good ionic conductivity (0.79 mS·cm-1), and favorable antibacterial and self-healing properties. These eutectogels achieve 90% antibacterial effect, show excellent biocompatibility, and can be used as sensors to monitor human activities with strong stability and durability. The in vivo studies indicate that the eutectogels can improve the wound healing process which makes them an effective option for biological dressings.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Activity of Copolymer Structures from Bio-Based Monomers. 生物基单体共聚物结构的抗菌活性。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-14 DOI: 10.1021/acs.biomac.4c01203

Mónica C S Fernandes, Rita Branco, Patrícia Pereira, Jorge F J Coelho, Paula V Morais, Arménio C Serra

{"title":"Antimicrobial Activity of Copolymer Structures from Bio-Based Monomers.","authors":"Mónica C S Fernandes, Rita Branco, Patrícia Pereira, Jorge F J Coelho, Paula V Morais, Arménio C Serra","doi":"10.1021/acs.biomac.4c01203","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01203","url":null,"abstract":"The urgent need for new antimicrobial compounds has led scientists to explore antimicrobial peptides (AMPs) and antimicrobial polymers as solutions for multidrug resistance. In this study, we synthesized copolymers with cationic and hydrophobic moieties by free-radical polymerization (FRP) using a chain transfer agent to control molecular weights. The potential of natural products as part of the hydrophobic moiety was evaluated, along with variations in their monomer content (13-25%) and the molecular weight (MW) of the copolymer (5000-20,000 g·mol-1). Hydrophobicity was evaluated using the theoretical Log Poct values and surface areas (SAs). Biological assays included antimicrobial activity against Escherichia coli and Staphylococcus aureus standard strains, hemolytic activity in red blood cells (RBC), and cytotoxicity tests against HEK293T cells. Keys findings indicate that copolymers with tropolone moieties, lower MWs, and an optimal balance between hydrophobic and cationic moieties show a promising basis for future generations of antimicrobials.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Customizable Glycopolymers as Adjuvants for Cancer Immunotherapy: From Branching Degree Optimization to Cell Surface Engineering. 可定制的糖聚合物作为癌症免疫疗法的佐剂：从分支度优化到细胞表面工程。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-13 DOI: 10.1021/acs.biomac.4c01230

Zhichen Zhu, Xingyu Heng, Fangjian Shan, He Yang, Yichen Wang, Hengyuan Zhang, Gaojian Chen, Hong Chen

引用次数: 0

Alkylated RALA-Derived Peptides for Efficient Gene Delivery. 用于高效基因传递的烷基化 RALA 衍生肽。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-13 DOI: 10.1021/acs.biomac.4c01355

Xuelin Zhang, Yexi Zhang, Xi Rong, Chuanmei Tang, Huiye Liu, Lei Yue, Rongxin Su, Yuefei Wang, Wei Qi

引用次数: 0