Biomacromolecules最新文献

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Bacterial-Infection-Triggered Release of Antibacterial Aldehyde from Triblock Copolyether Hydrogels. 细菌感染触发三嵌段共聚醚水凝胶释放抗菌醛。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-12 DOI: 10.1021/acs.biomac.4c00586
Neha Choudhury, Seongeun Cho, Jinsu Baek, Jinkee Hong, Byeong-Su Kim
{"title":"Bacterial-Infection-Triggered Release of Antibacterial Aldehyde from Triblock Copolyether Hydrogels.","authors":"Neha Choudhury, Seongeun Cho, Jinsu Baek, Jinkee Hong, Byeong-Su Kim","doi":"10.1021/acs.biomac.4c00586","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00586","url":null,"abstract":"<p><p>Bacterial infections pose a significant threat to public health worldwide. Hydrogel-based biomaterials have proven to be particularly useful in addressing persistent bacterial infections due to their stimuli-responsive degradability, high biocompatibility, ability to release antibacterial agents on demand, and long-lasting antibacterial activity. Herein, we fabricated ABA-type triblock copolyether hydrogels, wherein, hexanal, a bioactive aldehyde with antibacterial activity, was affixed to the hydrophobic micellar core via acetal linkage. The hydrogel exhibited degradation under acidic environment via the hydrolysis of acetal linkages, leading to the concomitant release of hexanal to exhibit highly potent bactericidal activity against both <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Furthermore, a dual-mode release of the model therapeutic agent Nile Red from the hydrophobic micellar core of the hydrogel in conjunction with hexanal was demonstrated using this system. We anticipate that this study will provide a new platform for the development of hydrogels with tailorable release profiles for biologically active compounds that are activated by the acidification triggered by bacterial infection.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supramolecularly-Cross-Linked Nanogel Assemblies for On-Demand, Ultrasound-Triggered Chemotherapy. 用于按需超声触发化疗的超分子交联纳米凝胶组装体
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-12 DOI: 10.1021/acs.biomac.3c01432
Matthew A Campea, Cameron Macdonald, Todd Hoare
{"title":"Supramolecularly-Cross-Linked Nanogel Assemblies for On-Demand, Ultrasound-Triggered Chemotherapy.","authors":"Matthew A Campea, Cameron Macdonald, Todd Hoare","doi":"10.1021/acs.biomac.3c01432","DOIUrl":"https://doi.org/10.1021/acs.biomac.3c01432","url":null,"abstract":"<p><p>Stimulating the release of small nanoparticles (NPs) from a larger NP via the application of an exogenous stimulus offers the potential to address the different size requirements for circulation versus penetration that hinder chemotherapeutic drug delivery. Herein, we report a size-switching nanoassembly-based drug delivery system comprised of ultrasmall starch nanoparticles (SNPs, ∼20-50 nm major size fraction) encapsulated in a poly(oligo(ethylene glycol) methyl ether methacrylate) nanogel (POEGMA, ∼150 nm major size fraction) cross-linked via supramolecular PEG/α-cyclodextrin (α-CD) interactions. Upon heating the nanogel using a non-invasive, high-intensity focused ultrasound (HIFU) trigger, the thermoresponsive POEGMA-CD nanoassemblies are locally de-cross-linked, inducing in situ release of the highly penetrative drug-loaded SNPs. HIFU triggering increased the release of nanoassembly-loaded DOX from 17 to 37% after 3 h, a result correlated with significantly more effective tumor killing relative to nanoassemblies in the absence of HIFU or drug alone. Furthermore, 1.5× more total fluorescence was observed inside a tumor spheroid when nanoassemblies prepared with fluorophore-labeled SNPs were triggered with HIFU relative to the absence of HIFU. We anticipate this strategy holds promise for delivering tunable doses of chemotherapeutic drugs both at and within a tumor site using a non-invasive triggering approach.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly Compressible, Superabsorbent, and Biocompatible Hybrid Cryogel Constructs Comprising Functionalized Chitosan and St. John's Wort Extract. 由功能化壳聚糖和圣约翰草提取物组成的高可压缩性、超吸水性和生物相容性混合低温凝胶结构。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-11 DOI: 10.1021/acs.biomac.4c00496
Ioana-Victoria Platon, Claudiu-Augustin Ghiorghita, Maria Marinela Lazar, Ana Clara Aprotosoaie, Adina Catinca Gradinaru, Isabella Nacu, Liliana Verestiuc, Alina Nicolescu, Nina Ciocarlan, Maria Valentina Dinu
{"title":"Highly Compressible, Superabsorbent, and Biocompatible Hybrid Cryogel Constructs Comprising Functionalized Chitosan and St. John's Wort Extract.","authors":"Ioana-Victoria Platon, Claudiu-Augustin Ghiorghita, Maria Marinela Lazar, Ana Clara Aprotosoaie, Adina Catinca Gradinaru, Isabella Nacu, Liliana Verestiuc, Alina Nicolescu, Nina Ciocarlan, Maria Valentina Dinu","doi":"10.1021/acs.biomac.4c00496","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00496","url":null,"abstract":"<p><p>Biobased porous hydrogels enriched with phytocompounds-rich herbal extracts have aroused great interest in recent years, especially in healthcare. In this study, new macroporous hybrid cryogel constructs comprising thiourea-containing chitosan (CSTU) derivative and a <i>Hypericum perforatum</i> L. extract (HYP<sub>E</sub>), commonly known as St John's wort, were prepared by a facile one-pot ice-templating strategy. Benefiting from the strong interactions between the functional groups of the CSTU matrix and those of polyphenols in HYP<sub>E</sub>, the hybrid cryogels possess excellent liquid absorption capacity, mechanical resilience, antioxidant performance, and a broad spectrum of antibacterial activity simultaneously. Thus, owing to their design, the hybrid constructs exhibit an interconnected porous architecture with the ability to absorb over 33 and 136 times their dry weight, respectively, when contacted with a phosphate buffer solution (pH 7.4) and an acidic aqueous solution (pH 2). These cryogel constructs have extremely high compressive strengths ranging from 839 to 1045 kPa and withstand elevated strains of over 70% without developing fractures. Moreover, the water-swollen hybrid cryogels with the highest HYP<sub>E</sub> content revealed a complete and instant shape recovery after uniaxial compression. The incorporation of HYP<sub>E</sub> into CSTU cryogels enabled substantial improvement in scavenging reactive oxygen species and an expanded antibacterial spectrum toward multiple pathogens, including Gram-positive bacteria (<i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>), Gram-negative bacteria (<i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>), and fungi (<i>Candida albicans</i>). Cell viability experiments demonstrated the cytocompatibility of the 3D cryogel constructs, which did not induce changes in the fibroblast morphology. This work showcases a simple and effective strategy to immobilize HYP<sub>E</sub> extracts on CSTU 3D networks, allowing the development of novel multifunctional platforms with promising potential in hemostasis, wound dressing, and dermal regeneration scaffolds.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multibiofunctional Self-healing Adhesive Injectable Nanocomposite Polysaccharide Hydrogel. 多生物功能自愈合粘合剂可注射纳米复合多糖水凝胶。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-11 DOI: 10.1021/acs.biomac.4c00016
Pritiranjan Mondal, Kaushik Chatterjee
{"title":"Multibiofunctional Self-healing Adhesive Injectable Nanocomposite Polysaccharide Hydrogel.","authors":"Pritiranjan Mondal, Kaushik Chatterjee","doi":"10.1021/acs.biomac.4c00016","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00016","url":null,"abstract":"<p><p>Injectable hydrogels with good antimicrobial and antioxidant properties, self-healing characteristics, suitable mechanical properties, and therapeutic effects have great practical significance for developing treatments for pressing healthcare challenges. Herein, we have designed a novel, self-healing injectable hydrogel composite incorporating cross-linked biofunctional nanomaterials by mixing alginate aldehyde (Ox-Alg), quaternized chitosan (QCS), adipic acid dihydrazide (ADH), and copper oxide nanosheets surface functionalized with folic acid as the bioligand (F-CuO). Gelation was achieved under physiological conditions via the dynamic Schiff base cross-linking mechanism. The developed nanocomposite injectable hydrogel demonstrated the fast self-healing ability essential to bear deformation and outstanding antibacterial properties along with ROS scavenging ability. Furthermore, the optimized formulation of our F-CuO-embedded injectable hydrogel exhibited excellent cytocompatibility, blood compatibility, and <i>in vitro</i> wound healing performance. Taken together, the F-CuO nanosheet cross-linked injectable hydrogel composite presented herein offers a promising candidate biomaterial with multifunctional properties to develop solutions for addressing clinical challenges.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Confining Nano-ZrO2 in Nanodomains Leads to Electroactive Artificial Muscle with Large Deformation. 将纳米氧化锆封闭在纳米域中可获得具有大变形的电活性人工肌肉
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-10 DOI: 10.1021/acs.biomac.4c00431
Yiting Cai, Zheqi Chen, Yingwu Luo
{"title":"Confining Nano-ZrO<sub>2</sub> in Nanodomains Leads to Electroactive Artificial Muscle with Large Deformation.","authors":"Yiting Cai, Zheqi Chen, Yingwu Luo","doi":"10.1021/acs.biomac.4c00431","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00431","url":null,"abstract":"<p><p>Dielectric elastomers generate muscle-like electroactive actuation, which is applicable in soft machines, medical devices, etc. However, the actuation strain and energy density of most dielectric elastomers, in the absence of prestretch, have long been limited to ∼20% and ∼10 kJ m<sup>-3</sup>, respectively. Here, we report a dielectric elastomer with ZrO<sub>2</sub> nanoparticles confined in nanodomains, which achieves an actuation strain >100% and an energy density of ∼150 kJ m<sup>-3</sup> without prestretch. We decorate the surface of each nanoparticle with a layer of a diblock oligomer, poly(acrylic acid-<i>b</i>-styrene). The surface-decorated nanoparticles coassemble with a triblock copolymer elastomer, poly(styrene-<i>b</i>-(2-ethylhexyl acrylate)-<i>b</i>-styrene) during cosolvent casting. Consequently, the nanoparticles are confined in the polystyrene nanodomains, which results in a dielectric elastomer nanocomposite with a low modulus, high breakdown strength, and intense strain-hardening behavior. During the actuation, the nanocomposite avoids the snap-through instability that most elastomers would suffer and achieves a superior actuation performance.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphorylating Tannin in Urea System: A Simple Approach for Enhanced Methylene Blue Removal from Aqueous Media 尿素体系中的磷酸化单宁:提高水介质中亚甲蓝去除率的简单方法
IF 6.2 2区 化学
Biomacromolecules Pub Date : 2024-07-10 DOI: 10.1021/acs.biomac.4c00236
Leila Azaryouh, Anass Ait Benhamou, Khalid Aziz, Houssine Khalili, Aleksander Jaworski, Latif Ullah, Abdelghani Boussetta, Adil Aboulkas, Amine Moubarik, Mounir El Achaby, Zineb Kassab
{"title":"Phosphorylating Tannin in Urea System: A Simple Approach for Enhanced Methylene Blue Removal from Aqueous Media","authors":"Leila Azaryouh, Anass Ait Benhamou, Khalid Aziz, Houssine Khalili, Aleksander Jaworski, Latif Ullah, Abdelghani Boussetta, Adil Aboulkas, Amine Moubarik, Mounir El Achaby, Zineb Kassab","doi":"10.1021/acs.biomac.4c00236","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00236","url":null,"abstract":"Tannin, after lignin, is one of the most abundant sources of natural aromatic biomolecules. It has been used and chemically modified during the past few decades to create novel biobased materials. This work intended to functionalize for the first time quebracho Tannin (T) through a simple phosphorylation process in a urea system. The phosphorylation of tannin was studied by Fourier transform infrared spectroscopy (FTIR), NMR, inductively coupled plasma optical emission spectroscopy (ICP-OES), and X-ray fluorescence spectrometry (XRF), while further characterization was performed by scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX) and thermogravimetric analysis (TGA) to investigate the morphology, composition, structure, and thermal degradation of the phosphorylated material. Results indicated the occurrence of phosphorylation, suggesting the insertion of phosphate-containing groups into the tannin structure, revealing a high content of phosphate for modified tannin (PT). This elevated phosphorus content serves as evidence for the successful incorporation of phosphate groups through the functionalization process. The corresponding PT and T were employed as adsorbents for methylene blue (MB) removal from aqueous solutions. The results revealed that the Langmuir isotherm model effectively represents the adsorption isotherms. Additionally, the pseudo-second-order model indicates that chemisorption predominantly controls the adsorption mechanism. This finding also supports the fact that the introduced phosphate groups via the phosphorylation process significantly contributed to the improved adsorption capacity. Under neutral pH conditions and at room temperature, the material achieved an impressive adsorption capacity of 339.26 mg·g<sup>–1</sup> in about 2 h.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":6.2,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141566783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-Assembled DNA Microflowers for Platelet-Derived Extracellular Vesicle Isolation and Infected Wound Healing. 用于血小板衍生细胞外囊泡分离和感染性伤口愈合的自组装 DNA 微流。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-10 DOI: 10.1021/acs.biomac.4c00398
Tong Zhu, Boyue Fan, Ziju He, Zeyu Fan, Bangshun He, Wenjun Miao, Rongrong Huang
{"title":"Self-Assembled DNA Microflowers for Platelet-Derived Extracellular Vesicle Isolation and Infected Wound Healing.","authors":"Tong Zhu, Boyue Fan, Ziju He, Zeyu Fan, Bangshun He, Wenjun Miao, Rongrong Huang","doi":"10.1021/acs.biomac.4c00398","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00398","url":null,"abstract":"<p><p>Platelet-derived extracellular vesicles (PEVs) showing great potential in wound healing have attracted increasing attention recently. Nondestructive isolation and effective utilization strategies are highly conducive for PEVs developing into recognized therapeutic entities. Here, we present an efficient strategy for PEV isolation and bacterial infected wound healing based on self-assembled DNA microflowers. First, DNA microflowers are prepared using rolling circle amplification. Then, the hydrophobic interaction between cholesteryl modified on DNA microflowers and the phospholipid bilayer membrane of PEVs leads to the formation of a network structure with improved mechanical strength and the separation of PEVs from biological samples. Finally, controlled release of PEVs is achieved through bacterial-induced hydrogel degradation. <i>In vitro</i> experiments demonstrate the obtained DNA hydrogel with good cytocompatibility and therapeutic potential. Taken together, the DNA microflower-based hydrogels with bioadhesive, self-healing, tunable mechanical properties and bacteria-responsive behavior offer substantial potential for EV isolation and wound healing.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing Coiled Coils for Heterochiral Complexation to Enhance Binding and Enzymatic Stability. 设计异手性复合物线圈,增强结合力和酶稳定性。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-09 DOI: 10.1021/acs.biomac.4c00661
Vincent P Gray, Rachel A Letteri
{"title":"Designing Coiled Coils for Heterochiral Complexation to Enhance Binding and Enzymatic Stability.","authors":"Vincent P Gray, Rachel A Letteri","doi":"10.1021/acs.biomac.4c00661","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00661","url":null,"abstract":"<p><p>Coiled coils, commonly found in native proteins, are helical motifs important for mediating intermolecular interactions. While coiled coils are attractive for use in new therapies and biomaterials, the lack of enzymatic stability of naturally occurring l-peptides may limit their implementation in biological environments. d-peptides are of interest for biomedical applications as they are resistant to enzymatic degradation and recent reports indicate that stereochemistry-driven interactions, achieved by blending d- and l-peptides, yield access to a greater range of binding affinities and a resistance to enzymatic degradation compared to l-peptides alone. To our knowledge, this effect has not been studied in coiled coils. Here, we investigate the effects of blending heterochiral E/K coiled coils, which are a set of coiled coils widely used in biomaterials. We found that we needed to redesign the coiled coils from a repeating pattern of seven amino acids (heptad) to a repeating pattern of 11 amino acids (hendecad) to make them more amenable to heterochiral complex formation. The redesigned hendecad coiled coils form both homochiral and heterochiral complexes, where the heterochiral complexes have stronger heats of binding between the constituent peptides and are more enzymatically stable than the analogous homochiral complexes. Our results highlight the ability to design peptides to make them amenable to heterochiral complexation, so as to achieve desirable properties like increased enzymatic stability and stronger binding. Looking forward, understanding how to engineer peptides to utilize stereochemistry as a materials design tool will be important to the development of next-generation therapeutics and biomaterials.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141557307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protease-Driven Phase Separation of Elastin-Like Polypeptides. 蛋白酶驱动的弹性蛋白样多肽相分离。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-09 DOI: 10.1021/acs.biomac.4c00346
Brendan M Wirtz, Allison G Yun, Chloe Wick, Xiaojing J Gao, Danielle J Mai
{"title":"Protease-Driven Phase Separation of Elastin-Like Polypeptides.","authors":"Brendan M Wirtz, Allison G Yun, Chloe Wick, Xiaojing J Gao, Danielle J Mai","doi":"10.1021/acs.biomac.4c00346","DOIUrl":"10.1021/acs.biomac.4c00346","url":null,"abstract":"<p><p>Elastin-like polypeptides (ELPs) are a promising material platform for engineering stimuli-responsive biomaterials, as ELPs undergo phase separation above a tunable transition temperature. ELPs with phase behavior that is isothermally regulated by biological stimuli remain attractive for applications in biological systems. Herein, we report protease-driven phase separation of ELPs. Protease-responsive \"cleavable\" ELPs comprise a hydrophobic ELP block connected to a hydrophilic ELP block by a protease cleavage site linker. The hydrophilic ELP block acts as a solubility tag for the hydrophobic ELP block, creating a temperature window in which the cleavable ELP reactant is soluble and the proteolytically generated hydrophobic ELP block is insoluble. Within this temperature window, isothermal, protease-driven phase separation occurs when a critical concentration of hydrophobic cleavage product accumulates. Furthermore, protease-driven phase separation is generalizable to four compatible protease-cleavable ELP pairings. This work presents exciting opportunities to regulate ELP phase behavior in biological systems using proteases.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Hemostatic Tranexamic Acid-Induced Fast Gelation and Mechanical Reinforcement of Polydimethylacrylamide/Carboxymethyl Chitosan Hydrogel for Hemostasis and Wound Healing". 用于止血和伤口愈合的聚二甲基丙烯酰胺/羧甲基壳聚糖水凝胶的止血氨甲环酸诱导快速凝胶化和机械加固》的更正。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2024-07-09 DOI: 10.1021/acs.biomac.4c00700
Yi Wang, Peiyue Pan, Hao Liang, Jing Zhou, Chuan Guo, Lijuan Zhao, Jinrong Wu
{"title":"Correction to \"Hemostatic Tranexamic Acid-Induced Fast Gelation and Mechanical Reinforcement of Polydimethylacrylamide/Carboxymethyl Chitosan Hydrogel for Hemostasis and Wound Healing\".","authors":"Yi Wang, Peiyue Pan, Hao Liang, Jing Zhou, Chuan Guo, Lijuan Zhao, Jinrong Wu","doi":"10.1021/acs.biomac.4c00700","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00700","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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