Biomacromolecules最新文献

Heteroatom Effect: Unraveling the Impact of Furan vs. Phenylene Ring Structures on the Gas Barrier Mechanism of Bio-Based Copolyester Elastomers 杂原子效应：揭示呋喃和苯炔环结构对生物基共聚弹性体气体屏障机制的影响

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-06 DOI: 10.1021/acs.biomac.6c01056

Xin Pan, Qingpeng Ou, Zhaoyang Wei, Jie Liu, Chao Chen, Jun You, Zhao Wang, Dean Shi, Weiwei Lei, Liqun Zhang, Robert K. Y. Li

{"title":"Heteroatom Effect: Unraveling the Impact of Furan vs. Phenylene Ring Structures on the Gas Barrier Mechanism of Bio-Based Copolyester Elastomers","authors":"Xin Pan, Qingpeng Ou, Zhaoyang Wei, Jie Liu, Chao Chen, Jun You, Zhao Wang, Dean Shi, Weiwei Lei, Liqun Zhang, Robert K. Y. Li","doi":"10.1021/acs.biomac.6c01056","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01056","url":null,"abstract":"The bio-based monomer 2,5-furandicarboxylic acid (FDCA) endows thermoplastics such as poly(ethylene furanoate) with superior gas barrier properties. However, its application and mechanistic role in cross-linkable elastomers remain underexplored. To examine the possible contribution of the furan oxygen within this compositional framework, we synthesized partially bio-based, cross-linkable polyester elastomers with varied FDCA-to-isophthalic acid (IPA) ratios. IPA, sharing a similar nonlinear geometry but lacking the oxygen heteroatom, served as an internal reference. The synthesized elastomers exhibited high molecular weights (Mn ≥ 24,800 g/mol) and excellent thermal stability (Td,5% up to 359 °C). Dynamic mechanical analysis showed that increasing FDCA content was accompanied by suppressed β-relaxation; specifically, the IPA-based reference showed a β-relaxation peak area 1.8 times larger than that of the FDCA-rich elastomer. Correspondingly, the oxygen permeability coefficient decreased substantially from 1.99 to 0.81 Barrer as the FDCA content increased from 0 to 60 mol %. These results support an important contribution of the oxygen-containing furan unit to restricted local segmental dynamics and improved oxygen barrier performance in cross-linked copolyester elastomers. This work provides a composition-based design strategy for sustainable elastomers requiring both elasticity and gas barrier properties.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7146–7156"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired Thermal-Stable Room-Temperature Phosphorescent Peptides 生物启发的室温热稳定磷光肽

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-07 DOI: 10.1021/acs.biomac.6c01491

Renjie Wang, Kunpeng Wei, Jiangyan Shi, Jiaran Li, Chongyi Chen

{"title":"Bioinspired Thermal-Stable Room-Temperature Phosphorescent Peptides","authors":"Renjie Wang, Kunpeng Wei, Jiangyan Shi, Jiaran Li, Chongyi Chen","doi":"10.1021/acs.biomac.6c01491","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01491","url":null,"abstract":"Room-temperature phosphorescence (RTP) materials exhibit long-lived emission, making them promising for bioimaging, information security, and flexible optoelectronics. Traditional inorganic systems are limited by toxicity and complex synthesis, whereas their organic counterparts often suffer from triplet exciton relaxation and quenching. Inspired by the β-barrel structure of green fluorescent protein, we introduce a “bionic confined structure” strategy using peptides synthesized via N-carboxyanhydride ring-opening polymerization with controllable secondary structures to construct hierarchical confined environments. α-Helical polypeptides exhibit negligible afterglow due to insufficient packing, whereas random coils provide dense confinement with long lifetimes but poor thermal stability. Surprisingly, the α-helix and β-sheet hybrid structure combines rigid backbones and ordered hydrogen bonding, achieving a long lifetime with excellent thermal robustness. This strategy also demonstrates universality across diverse luminophores, enabling multicolor and long-lived RTP. These findings highlight secondary-structure engineering via synthesized peptides as a powerful biomimetic approach for designing efficient, thermally stable, and biocompatible organic RTP materials.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7429–7440"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Responsive Recombinant Human Collagen Hydrogel Delivering Manganese-Based Nanozymes for Temporally Synergistic Repair of Oxidative Stress Wounds 双响应重组人胶原蛋白水凝胶递送锰基纳米酶用于氧化应激伤口的时间协同修复

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-22 DOI: 10.1021/acs.biomac.6c01637

Yan Wang, Lei Tong, Xinyue Zhang, Haihang Li, Tun Yuan, Xiang Deng, Na Li, Jie Liang, Yujiang Fan

{"title":"Dual-Responsive Recombinant Human Collagen Hydrogel Delivering Manganese-Based Nanozymes for Temporally Synergistic Repair of Oxidative Stress Wounds","authors":"Yan Wang, Lei Tong, Xinyue Zhang, Haihang Li, Tun Yuan, Xiang Deng, Na Li, Jie Liang, Yujiang Fan","doi":"10.1021/acs.biomac.6c01637","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01637","url":null,"abstract":"The clinical treatment of oxidative stress wounds remains challenging, as existing dressings often fail to simultaneously achieve timely clearance of microenvironmental reactive oxygen species (ROS) and effective reconstruction of the extracellular matrix. In this study, we constructed a dual-network hydrogel (denoted as Gel/MnBTC) composed of methacrylated recombinant human type III collagen (rhCol III-MA) and phenylboronic acid-grafted hyaluronic acid (HA-PBA), encapsulating polydopamine-coated manganese-based metal−organic framework nanozymes (MnBTC@PDA) within the matrix. Photoinduced free-radical polymerization synergized with dynamic boronate ester bonds to form a stable yet responsively dissociable matrix. Under acidic and high-ROS microenvironments, the system released nanozymes on demand, rapidly scavenging ROS via superoxide dismutase (SOD)-like and catalase (CAT)-like activities, thereby relieving oxidative inhibition of fibroblasts and restoring their migratory capacity. In the later stages, the collagen backbone significantly promoted re-epithelialization and the mature deposition of type I collagen. In vivo experiments demonstrated that Gel/MnBTC accelerated wound closure, remodeled the immune microenvironment, and exhibited favorable biocompatibility and temporally synergistic repair efficacy. These properties render Gel/MnBTC a promising smart-responsive dressing for the treatment of oxidative stress wounds.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7569–7584"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking Protein Encapsulation in ZIF-8 with Its Biofunction: Molecular Dynamics Simulation Validated by Experiments ZIF-8蛋白包封与生物功能的连接：实验验证的分子动力学模拟

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-19 DOI: 10.1021/acs.biomac.6c01524

Wangzi Liu, Qiwei Tang, Longyan Dai, Hong Qu, Yanzhao Diao, Xiao-Ping Zhou, Hong Li

{"title":"Linking Protein Encapsulation in ZIF-8 with Its Biofunction: Molecular Dynamics Simulation Validated by Experiments","authors":"Wangzi Liu, Qiwei Tang, Longyan Dai, Hong Qu, Yanzhao Diao, Xiao-Ping Zhou, Hong Li","doi":"10.1021/acs.biomac.6c01524","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01524","url":null,"abstract":"Correlating encapsulated protein with its bioactivity remains challenging, particularly for bone morphogenetic protein-2 (BMP-2), where both high loading efficiency and bioactivity must be ensured. In the study, molecular dynamics (MD) simulation was applied to elucidate the encapsulation process of BMP-2 within ZIF-8 and validated its functional consequences by experimental characterization in vitro. MD simulations suggest that BMP-2 rapidly anchors to the main crystal facets ((011), (112), and (222)) of ZIF-8 through predominant coordination bonds, accounting for over 57% of the adsorption energy. This facet-specific anchoring may guide subsequent framework growth, leading to confined encapsulation of the protein within the ZIF-8 lattice with a more compact yet structurally rigid conformation. Experimentally, the as-synthesized BMP-2@ZIF-8 features intraparticle nanodomains with a radius of gyration of 22.3 ± 3.2 Å, confirming single-protein confinement, and achieved an encapsulation efficiency of approximately 89%. Upon release, BMP-2 retained its native secondary structure and exhibited significantly enhanced osteogenic differentiation of bone marrow mesenchymal stem cells compared to free BMP-2, as evidenced by elevated alkaline phosphatase activity, calcium nodule formation, and activation of the p-Smad1/5/8 signaling pathway. A “facet-anchored guided growth” pathway, distinct from classical protein-induced biomineralization, was proposed to link the protein encapsulation process with its function. This work provides insight into the fundamental gap between encapsulated protein stability and its biofunction, facilitating the rational design of therapeutic protein delivery systems.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7504–7514"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermally Responsive 3D Printed Polyester Networks 热响应3D打印聚酯网络

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-07 DOI: 10.1021/acs.biomac.6c01353

Anshu Agarwal, Maddison I. Segal, Emily K. Augustine, Bridget A. Linders, Lindsey C. Brewster, Matthew L. Becker

{"title":"Thermally Responsive 3D Printed Polyester Networks","authors":"Anshu Agarwal, Maddison I. Segal, Emily K. Augustine, Bridget A. Linders, Lindsey C. Brewster, Matthew L. Becker","doi":"10.1021/acs.biomac.6c01353","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01353","url":null,"abstract":"Thermally responsive networks have been explored widely for drug delivery applications due to their ability to sequester or release payloads upon thermal triggering. Herein, we report a series of degradable, thermoresponsive polyesters synthesized via ring-opening copolymerization of succinic anhydride, an oligo(ethylene glycol)-derivatized epoxide, and allyl glycidyl ether, and used as resins for additive manufacturing. The oligomers were designed with lower critical solution temperatures such that below 10 °C, they are hydrophilic in aqueous solutions, and are hydrophobic near physiological temperature. Thermoresponsive polyester networks were fabricated via vat photopolymerization, with longer oligomers resulting in more crosslinks and therefore stiffer networks. When placed in water, substrates swelled at 4 °C, experiencing 2-fold volumetric and weight increases and decreased elongational moduli. When solutions were warmed to 37 °C, samples expelled water, recovering their dry properties. This work establishes the development of degradable, 3D printed networks with temperature-induced control over swelling, morphology, and mechanical properties.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7316–7324"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A “Capture-and-Lock” Ozone-Reservoir Hydrogel for Rheumatoid Arthritis Therapy 用于类风湿关节炎治疗的“捕获和锁定”臭氧储层水凝胶

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-07 DOI: 10.1021/acs.biomac.6c00978

Xiangjing Kong, Xianghui Cao, Qianqian Cao, Tongfeng Han, Guotai Li, Qihui Zhou, Shoushi Wang

{"title":"A “Capture-and-Lock” Ozone-Reservoir Hydrogel for Rheumatoid Arthritis Therapy","authors":"Xiangjing Kong, Xianghui Cao, Qianqian Cao, Tongfeng Han, Guotai Li, Qihui Zhou, Shoushi Wang","doi":"10.1021/acs.biomac.6c00978","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c00978","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic autoimmune disease driven by excessive reactive oxygen species (ROS) and M1 polarization, leading to synovial inflammation and bone destruction. Current immunosuppressants cannot target these core mechanisms and cause severe side effects. Ozone shows potential for RA treatment via anti-oxidant and anti-inflammatory effects, but its instability, rapid diffusion, and short retention severely limit clinical efficacy. Herein, we develop an injectable ozone-reservoir hydrogel (O3@F@OHC) by covalently incorporating perfluorinated polymer (PFAM) into a Schiff-base crosslinked network of oxidized hyaluronic acid and carboxymethyl chitosan. The hydrogel achieves stable ozone loading and sustained release for over 48 h through a “capture-and-lock” mechanism, with PFAM acting as an efficient “ozone sponge”. This hydrogel also exhibits favorable self-healing, biocompatibility, and adaptive biodegradability. In vitro, ozone released from O3@F@OHC hydrogel could activate endogenous antioxidant defense system, thereby enhances cellular antioxidant capacity, eliminates excessive intracellular free radicals, downregulates inducible nitric oxide synthase (iNOS) expression, and ultimately exerts anti-inflammatory effects. In rats with collagen-induced arthritis, this hydrogel alleviates synovial inflammation and bone destruction. This work provides a promising strategy for ozone-based intra-articular therapy of RA.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7121–7133"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zwitterionic Fluorinated Phosphocholine Block Copolymer Nanoparticles with Aggregation-Induced Emission for Dual-Modality 19F MRI/Fluorescence Bioimaging 具有聚集诱导发射的两性离子氟化磷胆碱嵌段共聚物纳米颗粒用于双模态19F MRI/荧光生物成像

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-20 DOI: 10.1021/acs.biomac.6c02043

Wenze Xiao, Deshuo Wang, Juan Yu, Dekun Huang, Sujing Liu, Jingjiang Sun, Jianjiang He, Qingfu Wang, Yanan Li, Wei Zhao

{"title":"Zwitterionic Fluorinated Phosphocholine Block Copolymer Nanoparticles with Aggregation-Induced Emission for Dual-Modality 19F MRI/Fluorescence Bioimaging","authors":"Wenze Xiao, Deshuo Wang, Juan Yu, Dekun Huang, Sujing Liu, Jingjiang Sun, Jianjiang He, Qingfu Wang, Yanan Li, Wei Zhao","doi":"10.1021/acs.biomac.6c02043","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c02043","url":null,"abstract":"Fluorine-19 magnetic resonance imaging (19F MRI) offers low-background, concentration-responsive imaging but suffers from low sensitivity and short transverse relaxation times. Aggregation-induced emission (AIE) fluorophores provide complementary optical imaging through strong fluorescence upon aggregation. Here, fluorinated amphiphilic block copolymers were prepared by reversible addition−fragmentation chain-transfer (RAFT) polymerization of dimethylaminoethyl methacrylate (DMAEMA) and tetraphenylethylene acrylate (TPEA), followed by phosphocholine fluorination. The resulting PTPE-PFCP nanoparticles self-assembled into core−shell structures with a hydrophobic AIE-active PTPE core and a hydrophilic fluorinated phosphocholine corona. The optimized nanoparticles showed well-resolved 19F signals, with T1 and T2 values of 0.222 and 0.184 s, respectively, and gave readily detectable 19F MRI signals. Fluorescence increased over 6 h, while cell viability remained above 70% at 100 μM, with time-dependent cellular fluorescence consistent with nanoparticle uptake. This work presents a feasible strategy for fluorinated AIE-active copolymers as dual-mode 19F MRI/fluorescence imaging probes.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7805–7814"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Protein Association with High Drug-Loaded Polymer Micelles: An Atomistic Molecular Dynamics Study 血浆蛋白与高载药聚合物胶束的关联：原子分子动力学研究

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-07 DOI: 10.1021/acs.biomac.6c01198

Maksym Karachevtsev, Terttu Hukka, Alex Bunker, Mikko Karttunen, Robert Luxenhofer

{"title":"Plasma Protein Association with High Drug-Loaded Polymer Micelles: An Atomistic Molecular Dynamics Study","authors":"Maksym Karachevtsev, Terttu Hukka, Alex Bunker, Mikko Karttunen, Robert Luxenhofer","doi":"10.1021/acs.biomac.6c01198","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01198","url":null,"abstract":"Polymeric micelles are widely studied drug delivery platforms whose interactions with plasma proteins influence in vivo performance. However, the combined effects of non-pEG hydrophilic coronas and high drug loading on protein adsorption remain poorly understood. We performed all-atom molecular dynamics (MD) simulations to investigate the association of three plasma proteins: apolipoprotein E (ApoE), human serum albumin (HSA), and immunoglobulin G (IgG), with curcumin-loaded ABA triblock copolymer micelles. To isolate corona effects, micelles shared an hydrophobic core chemistry and differed only in the hydrophilic A-block: poly(ethylene glycol) (pEG), poly(N,N-dimethylacrylamide) (pDMAA), or poly(sarcosine) (pSAR). Two drug loadings (20% and 60% drug/polymer mass ratio) were examined. Binding was assessed via contact areas, hydrogen bonds, and interaction energies. pEG micelles showed the strongest protein association. pDMAA and pSAR exhibited weaker, surface-limited interactions. These simulations provide molecular-level insight into protein adsorption on drug-loaded polymeric micelles and compare alternative hydrophilic A-blocks to pEG.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7194–7205"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular Crosslinking-Based Photosensitizing Nanogels via Host−Guest Assembly for Targeted Photodynamic Therapy 基于主-客体组装的超分子交联光敏纳米凝胶用于靶向光动力治疗

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-07 DOI: 10.1021/acs.biomac.6c01180

Enfal Civril, Burak Yıldız, Aysun Degirmenci, Rana Sanyal, M. Kasım Şener, Amitav Sanyal

{"title":"Supramolecular Crosslinking-Based Photosensitizing Nanogels via Host−Guest Assembly for Targeted Photodynamic Therapy","authors":"Enfal Civril, Burak Yıldız, Aysun Degirmenci, Rana Sanyal, M. Kasım Şener, Amitav Sanyal","doi":"10.1021/acs.biomac.6c01180","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01180","url":null,"abstract":"Over the past decade, nanogels (NGs) have emerged as a promising drug delivery platform for targeted cancer therapy. Herein, we report the design and fabrication of a multi-functional photosensitizing nanogel system for photodynamic therapy (PDT) based on supramolecularly crosslinked biocompatible polymers. Nanogels were formed via host−guest interactions between β-cyclodextrin (β-CD)-conjugated polymers and a tetravalent adamantane-functionalized zinc phthalocyanine (Ada-TEG-ZnPc). Importantly, the Ada-TEG-ZnPc moiety functions as both a physical crosslinker and a photosensitizer, enabling the one-step assembly of photosensitizing nanogels. Post-assembly supramolecular functionalization with an adamantane-conjugated integrin-targeting peptide yielded cancer cell-targeting nanogels. It is demonstrated that both Ada-TEG-ZnPc and the resulting nanogels generated singlet oxygen efficiently upon light irradiation. In vitro studies using MDA-MB-231 breast cancer cells confirmed effective cellular internalization of both targeted and nontargeted nanogels, while enhanced uptake was observed for targeting peptide-functionalized systems. Reactive oxygen species generation within cells was confirmed, and pronounced phototoxicity was observed under light irradiation, with no dark toxicity. Overall, the targeted photodynamic nanogels exhibited high efficacy, highlighting the potential of supramolecular macromolecular design for targeted PDT applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7181–7193"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-Water-Content Lignosulfonate Gels with Dense Triple Hydrogen-Bonding Networks for Wearable Sensors and Photothermal-Electric Conversion 具有密集三氢键网络的低含水量木质素磺酸凝胶用于可穿戴传感器和光热-电转换

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-11-09 Epub Date: 2026-10-18 DOI: 10.1021/acs.biomac.6c01883

Haoyu Zhang, Meng Wang, Haocheng Fu, Like Ning, Guoping Yu, Jiangtao Hu, Farzad Seidi, Chao Liu, Huining Xiao

{"title":"Low-Water-Content Lignosulfonate Gels with Dense Triple Hydrogen-Bonding Networks for Wearable Sensors and Photothermal-Electric Conversion","authors":"Haoyu Zhang, Meng Wang, Haocheng Fu, Like Ning, Guoping Yu, Jiangtao Hu, Farzad Seidi, Chao Liu, Huining Xiao","doi":"10.1021/acs.biomac.6c01883","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01883","url":null,"abstract":"Achieving mechanical robustness, efficient ion transport, environmental tolerance, and energy conversion in a sustainable soft conductor remains challenging. Herein, a low-water-content supramolecular gel (PLPG) was fabricated via evaporation-induced co-assembly of poly(vinyl alcohol) (PVA), phytic acid (PA), and lignosulfonate (LS). Evaporation reconstructed a ternary hydrogen-bonding network. At an optimized LS content, PLPG-L0.5 exhibited 267 kPa tensile strength and 0.2676 S m−1 ionic conductivity, retaining flexibility and conductivity after 7 days at −20 °C. As a strain sensor, it showed electrical responses after 3000 s cyclic loading tests and enabled monitoring of human motion. The aromatic conjugated structure of LS allowed rapid heating above 65 °C under solar irradiation (0.1 W cm−2). Integrated with a thermoelectric generator, the system tuned the electrical output with light intensity and drove a miniature fan. This offers a strategy for lignin-based soft materials integrating wearable sensing and photothermal energy conversion.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 11","pages":"7721–7733"},"PeriodicalIF":5.9,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149368580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0