Biomacromolecules最新文献_第10页

NaCl-Responsive Ultrashort Peptide to Trigger Self-Assembly of TPE-Capped Supramolecular Hydrogelator. 氯化钠响应超短肽触发tpe包封的超分子凝胶自组装。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-02 DOI: 10.1021/acs.biomac.4c01050

Xiangyi Liu, Lulu Du, Jia Liu, Yueting Shi, Qipeng Liu, Ying Xu, Yingying Xia, Xiaiting Wang, Dan Ding, Xingyi Li, Deqing Lin

引用次数: 0

Injectable and 3D-Printable Semi-Interpenetrating Polymer Networks Based on Modified Sodium Alginate for Cell Spheroid Formation. 基于修饰海藻酸钠的可注射和3d打印半互穿聚合物网络用于细胞球形形成。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-29 DOI: 10.1021/acs.biomac.4c01343

Sofia Falia Saravanou, Thomai Samouilidou, Constantinos Tsitsilianis, Stavros Taraviras, George Pasparakis

{"title":"Injectable and 3D-Printable Semi-Interpenetrating Polymer Networks Based on Modified Sodium Alginate for Cell Spheroid Formation.","authors":"Sofia Falia Saravanou, Thomai Samouilidou, Constantinos Tsitsilianis, Stavros Taraviras, George Pasparakis","doi":"10.1021/acs.biomac.4c01343","DOIUrl":"10.1021/acs.biomac.4c01343","url":null,"abstract":"We report on 3D-printable polymer networks based on the combination of modified alginate-based polymer blends; two alginate polymers were prepared, namely, a thermoresponsive polymer grafted with P(NIPAM86-co-NtBAM14)-NH2 copolymer chains and a second polymer modified with diol/pH-sensitive 3-aminophenylboronic acid. The gelation properties were determined by the hydrophobic association of the thermosensitive chains and the formation of boronate esters. At a mixing ratio of 70/30 wt % of the thermo/diol-responsive polymers, the semi-interpenetrating network exhibited an optimum storage modulus ranging from ca. 150 Pa at 20 °C up to ca. 480 Pa at 37 °C due to the stimulated cross-linking synergism. The resulting bioink blends could promote the rapid formation of cell spheroids with an average diameter of 62.5 μm within 24 h. The network could easily be dissociated by the addition of free glucose, acting as an antagonistic disruptor of the cross-links. The proposed material was found to be nontoxic, with adequate injectability and 3D printability.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"567-578"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composite Hyaluronic Acid Gas-Entrapping Materials to Promote Wound Healing. 复合玻尿酸气体包裹材料促进伤口愈合。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2025-01-02 DOI: 10.1021/acs.biomac.4c00904

Emily Witt, Emily B Petersen, Eyas Alzayadneh, Ryan J Courtney, Marc J Brouillette, Qi Wang, Maxwell Y Sakyi, Nicole A D Watson, Dominic Rivas, Jianling Bi, Lindsey Culver, Kyle Balk, Colin Reis, Slyn Uaroon, Kaitlyn A McClintic, Samual Hatfield, Kristan S Worthington, Edward A Sander, Giovanni Traverso, Leo E Otterbein, Jessica E Goetz, Douglas C Fredericks, James D Byrne

{"title":"Composite Hyaluronic Acid Gas-Entrapping Materials to Promote Wound Healing.","authors":"Emily Witt, Emily B Petersen, Eyas Alzayadneh, Ryan J Courtney, Marc J Brouillette, Qi Wang, Maxwell Y Sakyi, Nicole A D Watson, Dominic Rivas, Jianling Bi, Lindsey Culver, Kyle Balk, Colin Reis, Slyn Uaroon, Kaitlyn A McClintic, Samual Hatfield, Kristan S Worthington, Edward A Sander, Giovanni Traverso, Leo E Otterbein, Jessica E Goetz, Douglas C Fredericks, James D Byrne","doi":"10.1021/acs.biomac.4c00904","DOIUrl":"10.1021/acs.biomac.4c00904","url":null,"abstract":"Tissue repair is often impaired in pathological states, highlighting the need for innovative wound-healing technologies. This study introduces composite hyaluronic acid gas-entrapping materials (GEMs) delivering carbon monoxide (CO) to promote wound healing in pigs. These composite materials facilitate burst release followed by sustained release of CO over 48 h. In a porcine full-thickness wound model, CO-GEMs significantly accelerated wound closure compared to the standard-of-care dressing (Tegaderm). Wound area closure with CO-GEMs was 68.6% vs 56.8% on day 14, 41.0% vs 25.1% on day 28, and 26.9% vs 11.8% on day 42, effectively reducing healing time by 14 days. Histological analysis revealed increased epithelialization and neovascularization with reduced inflammation. These findings demonstrate the potential of CO-GEMs as a topical therapeutic to enhance tissue repair in clinically relevant models, supporting further testing for wound-healing applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"201-208"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Pulmonary and Splenic mRNA Delivery Using DOTAP-Incorporated Poly(β-Amino Ester)-Lipid Nanoparticles. 利用dotap结合的聚（β-氨基酯）脂质纳米颗粒增强肺和脾mRNA的传递。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2025-01-02 DOI: 10.1021/acs.biomac.4c01445

Yuduo Gao, Luwei Zhang, Ziyue Wang, Hao Bai, Chengfan Wu, Qi Shuai, Yunfeng Yan

{"title":"Enhanced Pulmonary and Splenic mRNA Delivery Using DOTAP-Incorporated Poly(β-Amino Ester)-Lipid Nanoparticles.","authors":"Yuduo Gao, Luwei Zhang, Ziyue Wang, Hao Bai, Chengfan Wu, Qi Shuai, Yunfeng Yan","doi":"10.1021/acs.biomac.4c01445","DOIUrl":"10.1021/acs.biomac.4c01445","url":null,"abstract":"mRNA-based therapies hold tremendous promise for treating various diseases, yet their clinical success is hindered by delivery challenges. This study developed a library of 140 lipocationic Poly(β-amino ester)s (PBAEs) and formulated lipid-polymer hybrid nanoparticles (LPHs) with four helper lipids, including 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), to enhance mRNA delivery. Initial in vitro screening of four representative PBAEs identified the D/P4-1 formulation (DOTAP/PBAE molar ratio of 4:1) as the most effective. Further screening of the library using this formulation identified eight top-performing LPHs. In vivo experiments confirmed high luciferase expression in the spleen and lungs of mice following intravenous administration of Luc mRNA-loaded LPHs. Detailed analysis revealed that DOTAP incorporation influenced LPH properties, including apparent pKa, surface charge, and internal hydrophobicity, enabling enhanced mRNA release and cellular uptake. This study demonstrates potent approaches to modulate PBAE-lipid nanoparticle properties by altering PBAE structures and nanoparticle composition, offering insights for designing effective hybrid carriers for mRNA therapeutics.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"623-634"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Internal Structure Dependence of Biodegradation for Polyamide 4 Thin Films in Seawater. 聚酰胺4薄膜在海水中生物降解的内部结构依赖性

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-12 DOI: 10.1021/acs.biomac.4c01304

Shunta Tamura, Haruki Mokudai, Takashi Masaki, Hironori Taguchi, Takako Kikuchi, Norifumi L Yamada, Hideki Seto, Hisao Matsuno, Keiji Tanaka

引用次数: 0

Vat-Based 3D-Bioprinted Scaffolds from Photocurable Bacterial Levan for Osteogenesis and Immunomodulation. 用于骨生成和免疫调节的基于光固化细菌Levan的3d生物打印支架。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-11 DOI: 10.1021/acs.biomac.4c01264

Yusuf Olatunji Waidi, Vasudev S Wagh, Shivangi Mishra, Siddharth Jhunjhunwala, Syed G Dastager, Kaushik Chatterjee

{"title":"Vat-Based 3D-Bioprinted Scaffolds from Photocurable Bacterial Levan for Osteogenesis and Immunomodulation.","authors":"Yusuf Olatunji Waidi, Vasudev S Wagh, Shivangi Mishra, Siddharth Jhunjhunwala, Syed G Dastager, Kaushik Chatterjee","doi":"10.1021/acs.biomac.4c01264","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01264","url":null,"abstract":"Emerging techniques of additive manufacturing, such as vat-based three-dimensional (3D) bioprinting, offer novel routes to prepare personalized scaffolds of complex geometries. However, there is a need to develop bioinks suitable for clinical translation. This study explored the potential of bacterial-sourced methacrylate levan (LeMA) as a bioink for the digital light processing (DLP) 3D bioprinting of bone tissue scaffolds. LeMA was successfully synthesized, characterized, and used to fabricate 3D-bioprinted scaffolds with excellent printability and physicochemical properties. In vitro studies demonstrated superior cytocompatibility of 15% w/v LeMA gels compared to 20% gels. 15% LeMA gels supported osteogenic differentiation , as evidenced by alkaline phosphatase activity and mineral deposition by MC3T3 pre-osteoblasts. Importantly, the LeMA hydrogels positively modulated the macrophage phenotype, promoting the expression of the anti-inflammatory marker CD206. These findings suggest that 3D-printed LeMA scaffolds can create a favorable microenvironment for bone regeneration, highlighting their potential for tissue repair and regeneration applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

F_OF₁-ATPase Biomolecular Motor: Structure, Motility Manipulations, and Biomedical Applications. fof1 - atp酶生物分子运动：结构、运动操纵和生物医学应用。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-11 DOI: 10.1021/acs.biomac.4c01553

Xuhui Zhou, Miao Sun, Xiu Yang, Mengliu Shao, Mengya Jin, Yuanbin She, Qingliang Yang, Gensheng Yang

{"title":"FOF1-ATPase Biomolecular Motor: Structure, Motility Manipulations, and Biomedical Applications.","authors":"Xuhui Zhou, Miao Sun, Xiu Yang, Mengliu Shao, Mengya Jin, Yuanbin She, Qingliang Yang, Gensheng Yang","doi":"10.1021/acs.biomac.4c01553","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01553","url":null,"abstract":"Biomolecular motors are dynamic systems found in organisms with high energy conversion efficiency. FOF1-ATPase is a rotary biomolecular motor known for its near 100% energy conversion efficiency. It utilizes the synthesis and hydrolysis of ATP to induce conformational changes in motor proteins, thereby converting chemical energy into mechanical motion. Given their high efficiency, autonomous propulsion capability, and modifiable structures, FOF1-ATPase motors have attracted significant attention for potential biomedical applications. This Review aims to introduce the detailed structure of FOF1-ATPase, explore various motility manipulation strategies, and summarize its applications in biological detection and cargo delivery. Additionally, innovative research methods are proposed to analyze the motion mechanism of FOF1-ATPase more comprehensively, with the goal of advancing its biomedical applications. Finally, this Review concludes with key insights and future perspectives.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enthalpy-Driven Interaction between Bovine Serum Albumin and Biomass-Derived Low-Melting Mixture Solvents (LoMMSs) for Efficient and Green Purification of Protein. 牛血清白蛋白与生物质衍生低熔点混合溶剂（LoMMSs）之间焓驱动的相互作用，用于高效和绿色的蛋白质纯化。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-09 DOI: 10.1021/acs.biomac.4c01639

Li Fu, Ya Liu, Jingjing Guo, Xueqing Zhang, Wenqiang Li, Jiayue Zhao, Ziying Zhen, Yu Chen

引用次数: 0

Study on Highly Sensitive Capacitive Pressure Sensor Based on Silk Fibroin-Lignin Nanoparticles Hydrogel. 丝素-木质素纳米颗粒水凝胶高灵敏度电容式压力传感器的研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-09 DOI: 10.1021/acs.biomac.4c01334

Lei Wang, Yue Wang, Simin Peng, Shuangyan Li, Silong Wu

引用次数: 0

Injectable Senolytic Hydrogel Depot for the Clearance of Senescent Cells. 可注射抗衰老水凝胶库清除衰老细胞。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-09 DOI: 10.1021/acs.biomac.4c00851

Lorenza Garau Paganella, Giovanni Bovone, Filippo Cuni, Céline Labouesse, Yifan Cui, Costanza Giampietro, Mark W Tibbitt

{"title":"Injectable Senolytic Hydrogel Depot for the Clearance of Senescent Cells.","authors":"Lorenza Garau Paganella, Giovanni Bovone, Filippo Cuni, Céline Labouesse, Yifan Cui, Costanza Giampietro, Mark W Tibbitt","doi":"10.1021/acs.biomac.4c00851","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00851","url":null,"abstract":"Small molecules are frontline therapeutics for many diseases; however, they are often limited by their poor solubility. Therefore, hydrophobic small molecules are often encapsulated or prepared as pure drug nanoparticles. Navitoclax, used to eliminate senescent cells, is one such small molecule that faces challenges in translation due to its hydrophobicity and toxic side effects. Further, as senescent cells exhibit context-dependent pathologic or beneficial properties, it is preferable to eliminate senescent cells locally. To formulate navitoclax and enable local treatment, we designed an injectable hydrogel loaded with navitoclax nanoparticles as a senolytic delivery vehicle. Navitoclax nanoparticles (Ø ∼ 110 nm) were prepared via solvent-antisolvent nanoprecipitation and formulated in an injectable polymer-nanoparticle (PNP) hydrogel to create a local senolytic depot. Navitoclax-loaded PNP hydrogels selectively cleared senescent cells in vitro in senescent endothelial monolayers. This work demonstrates the value of formulating lipophilic small molecules and the potential of localized drug delivery strategies to improve senolytic therapies.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0