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梯度pH水凝胶通过调节微环境pH值促进感染创面愈合。

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-07-14 DOI:10.1021/acs.biomac.5c00351

Yan Yang , Shizhuo Li , Yixuan Li , Mengyue Zhang , Shitong Li , Kun Liu , Tong Qiu , Honglian Dai

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引用次数: 0

摘要

健康的皮肤表面是一个平均pH值低于5的酸性环境，这有助于防止细菌感染。真皮的弱酸性环境不仅可以减少细菌感染，还会影响成纤维细胞的活性、血管内皮细胞的活性和免疫反应。天然的pH梯度有助于确保皮肤的完整性，加速皮肤损伤后的修复过程。本研究提出了一种基于gelma的梯度pH水凝胶用于感染皮肤伤口愈合。实验表明，梯度pH水凝胶具有良好的抗菌作用，并能促进成纤维细胞和内皮细胞的增殖和迁移。梯度pH水凝胶降低了伤口床的pH值，减少了细菌负荷，诱导巨噬细胞向M2极化和新生血管形成。梯度pH水凝胶通过调节Treg细胞促进毛囊再生。因此，这种水凝胶为细菌感染伤口的治疗提供了一种新的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gradient pH Hydrogel Promotes Infected Wound Healing through pH Regulation of Microenvironment

A healthy skin surface has an acidic environment with an average pH below 5, which helps to protect against bacterial infection. A weakly acidic environment of the dermis not only reduces bacterial infection but also affects fibroblasts’ activity, vascular endothelial cell activity, and the immune response. The natural pH gradient helps to ensure the integrity of the skin and accelerates the repair process, following skin damage. In this study, GelMA-based gradient pH hydrogel was proposed for infected skin wound healing. Experiments showed that the gradient pH hydrogel had good antibacterial effects and promoted the proliferation and migration of fibroblasts and endothelial cells. The gradient pH hydrogel lowered the pH of the wound bed, reduced the bacterial load, and induced macrophage polarization to M2 and neovascularization. The gradient pH hydrogel promoted hair follicle regeneration by modulating Treg cells. Thus, this hydrogel provides a new option for the treatment of bacterially infected wounds.

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来源期刊

Biomacromolecules

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.

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