BiomacromoleculesPub Date : 2025-07-14DOI: 10.1021/acs.biomac.5c00588
Cheng-Ti Hu , Zhi-Xuan Liang , Jhen-Yu Luo , Po-Hsun Chiu , Annabelle I. Day , Chih-Chen Hsieh , Po-Jen Shih , Jia-Han Li , Bo-I Kuo , I-Jong Wang , Jia-Yush Yen , Chi-An Dai
{"title":"Strategic Design of Biocompatible, Glistening-Free, and Foldable Artificial Intraocular Lenses Based on Hydro-Amphiphilic Ternary Copolymers","authors":"Cheng-Ti Hu , Zhi-Xuan Liang , Jhen-Yu Luo , Po-Hsun Chiu , Annabelle I. Day , Chih-Chen Hsieh , Po-Jen Shih , Jia-Han Li , Bo-I Kuo , I-Jong Wang , Jia-Yush Yen , Chi-An Dai","doi":"10.1021/acs.biomac.5c00588","DOIUrl":"10.1021/acs.biomac.5c00588","url":null,"abstract":"<div><div>The increasing prevalence of cataracts underscores the urgent need for intraocular lens (IOL) materials that provide optical clarity, foldability, glistening resistance, and long-term biocompatibility. In this study, we developed hydro-amphiphilic ternary copolymers composed of styrene, hydroxyethyl methacrylate (HEMA), and poly(ethylene glycol) phenyl ether acrylate (PEGPEA) to address these requirements. This rational design integrates the strength and refractive index of hydrophobic styrene with the flexibility and hydrophilicity of HEMA and PEGPEA. The optimized formulation (H3), comprising 50 wt % HEMA, 30 wt % PEGPEA, and 20 wt % styrene, showed excellent transparency after accelerated aging, sufficient modulus and elongation for safe surgical handling, and low cytotoxicity in CCK-8 assays. Cytokine analyses revealed no significant inflammatory response compared to a commercial hydrophobic acrylic IOL. These findings highlight hydro-amphiphilic copolymers as a promising next-generation material platform for IOLs, offering a biocompatible, glistening-free, and foldable solution for enhanced surgical outcomes and long-term patient satisfaction.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (164KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4612-4625"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiomacromoleculesPub Date : 2025-07-14DOI: 10.1021/acs.biomac.5c00289
Sikai Chen, Peng Lin, Jinglin Yuan, Miao Lv, Han Zhang
{"title":"Toward Renewable Water Treatments: Efficient and Sustainable Cationic Cellulose Nanofiber Flocculants Derived from Rice Straw","authors":"Sikai Chen, Peng Lin, Jinglin Yuan, Miao Lv, Han Zhang","doi":"10.1021/acs.biomac.5c00289","DOIUrl":"10.1021/acs.biomac.5c00289","url":null,"abstract":"<div><div>Flocculants are essential for removing pollutants from wastewater, yet conventional organic and inorganic types often lack renewability and pose risks of secondary pollution. In this study, a cationic cellulose nanofiber (CCNF) flocculant was developed from rice straw, offering enhanced flocculation performance, sustainability, and environmental compatibility. The cellulose nanofiber was extracted and cationically modified under mild conditions. Optimized modification enhanced cationic substitution, yielding a maximum SS removal of 98.9%. CCNF maintained stable performance under both acidic and alkaline conditions and was particularly effective in removing nanoscale SS and treating actual agricultural wastewater. Moreover, cationic modification did not significantly alter the biodegradability of cellulose, with CCNF showing a weight loss similar to that of unmodified CNF after 180 days in soil. The estimated cost of CCNF-3 was approximately 1.13 yuan/g, slightly higher than conventional flocculants, but with considerable environmental benefits.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (177KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4286-4296"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiomacromoleculesPub Date : 2025-07-14DOI: 10.1021/acs.biomac.5c00737
Deqing Zhao , Jingpeng He , Yaling Zhao , Kaibin Ma , Yang Xu , Qinqin Xia , Xinglin Xiong , Xuan Tang , Qingyi Zhao , Rongge Wang
{"title":"Efficient and Protective Upgrading of Uncondensed Lignin Extraction with High Yield and High Purity: Mechanistic Insights into Lewis Acid Catalysis Coupled with PEG Stabilization","authors":"Deqing Zhao , Jingpeng He , Yaling Zhao , Kaibin Ma , Yang Xu , Qinqin Xia , Xinglin Xiong , Xuan Tang , Qingyi Zhao , Rongge Wang","doi":"10.1021/acs.biomac.5c00737","DOIUrl":"10.1021/acs.biomac.5c00737","url":null,"abstract":"<div><div>Maximizing the extraction and valorization of highly reactive lignin from lignocellulosic biomass is crucial for lignin-first biorefining. However, achieving high yield, superior purity, and structural preservation simultaneously is challenging. Herein, we developed a Lewis acid-catalyzed deep eutectic solvent (DES) system employing ferric chloride (FeCl<sub>3</sub>) coordinated with polyethylene glycol (PEG) to selectively extract structurally intact lignin. The engineered DES system exhibited outstanding performance, achieving a lignin yield of 32.9% with a purity of 96.2%. Structural analysis indicated that the extracted lignin retained 53.21 β-O-4 linkages per 100 aromatic units, closely approximating the native structure of cellulolytic enzyme lignin (CEL: 58.53 β-O-4/100 Ar). The identification of characteristic β′-O-4 linkages verified that PEG grafting at the C<sub>α</sub> position effectively inhibited lignin condensation. Theoretical calculations further confirmed that FeCl<sub>3</sub> enhanced the hydrogen-bonding capacity of the ternary DES with lignin, thereby aiding lignin dissociation and improving separation efficiency. This work provides valuable insights into upgrading lignin fractionation for lignin valorization.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (134KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4675-4689"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saeed Davoodi, Faridah Namata, Tomas Rosén, Stephan V. Roth, Michael Malkoch, L. Daniel Söderberg and Fredrik Lundell*,
{"title":"","authors":"Saeed Davoodi, Faridah Namata, Tomas Rosén, Stephan V. Roth, Michael Malkoch, L. Daniel Söderberg and Fredrik Lundell*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yin Mei Chan, Nicola G. Judge, Yang Hu, Rebecca K. Willits, Neill Li and Matthew L. Becker*,
{"title":"","authors":"Yin Mei Chan, Nicola G. Judge, Yang Hu, Rebecca K. Willits, Neill Li and Matthew L. Becker*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00558","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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