Biomacromolecules最新文献_第9页

Humic Acid and Cellulose Nanocrystal-Based Antifreeze Nanocomposite Hydrogel Flexible Sensor 基于腐植酸和纤维素纳米晶体的防冻纳米复合水凝胶柔性传感器。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00624

Chenglin Yang , Xinyue Zhang , Xinhang Yu , Wenxiang Wang , Liangjiu Bai , Hou Chen , Lixia Yang , Huawei Yang , Donglei Wei

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引用次数: 0

Composition Engineering for Enhanced Photosensitization: A Toolbox for Biological Applications 增强光敏化的成分工程：生物应用工具箱。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00659

Mengyao Zhang , Jingbo Huang , Shunze Cheng , Yujie Bai , Pei Huang , Haili Zhang , Shunjie Liu , Hualei Wang , Yuanyuan Li

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引用次数: 0

Ibuprofen Conjugated Epsilon-poly‑l‑lysine Methacrylate Hydrogel Modulates Macrophage Polarization and Mitigates Inflammation In Vivo 布洛芬偶联聚赖氨酸甲基丙烯酸酯水凝胶调节巨噬细胞极化和减轻体内炎症。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00479

Yifan Lu , Bo Chen , Xiangxin Lou , Yi Li , Jinglei Wu , Haochen Yao , Bei Feng

{"title":"Ibuprofen Conjugated Epsilon-poly‑l‑lysine Methacrylate Hydrogel Modulates Macrophage Polarization and Mitigates Inflammation In Vivo","authors":"Yifan Lu , Bo Chen , Xiangxin Lou , Yi Li , Jinglei Wu , Haochen Yao , Bei Feng","doi":"10.1021/acs.biomac.5c00479","DOIUrl":"10.1021/acs.biomac.5c00479","url":null,"abstract":"<div><div>Epsilon-poly-<span>l</span>-lysine (EPL) is widely used in many biomedical applications due to its excellent antibacterial activity and good biocompatibility. In this study, we report an approach of carbodiimide chemistry to graft water-soluble EPL with hydrophobic drug ibuprofen (IBU) and then modify the obtained IBU-EPL conjugate with methacrylic anhydride (MA) to prepare IBU-EPL-MA. The IBU-EPL-MA was of good photo-cross-linkability to form hydrogel with sustained drug release and good blood compatibility. It significantly inhibited bacterial growth, promoted lipopolysaccharide (LPS)-induced macrophage polarization to the M2-like phenotype, and reduced reactive oxygen species (ROS) levels <em>in vitro</em>. The IBU-EPL-MA hydrogel elicited milder foreign body response (FBR) as evidenced by reduced fibrous capsule thickness, increased macrophage polarization to M2-like phenotype, and less extent of blood vessel formation surrounding implants in a mouse subcutaneous model. This study provides insights into multifunctional EPL-based biomaterials with antibacterial, anti-inflammatory, and sustained drug release capabilities that expand potential biomedical applications.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (134KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4464-4476"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing Self-Healing Hydrogels with Antibacterial Property Based on Host–Guest Interactions between Aminoazobenzene-Modified Gelatin and Polycyclodextrin for Prolonging the Shelf Life of Tyrosinase Enzyme 基于氨基偶氮苯改性明胶与聚环糊精主客体相互作用设计具有抗菌性能的自愈水凝胶以延长酪氨酸酶的保质期。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00346

Shaghayegh Vakili , Hamed Azadfar , Ebrahim Ahmadi , Zahra Mohamadnia , Atiyeh Mahdavi , Faezeh Hanifeh

{"title":"Designing Self-Healing Hydrogels with Antibacterial Property Based on Host–Guest Interactions between Aminoazobenzene-Modified Gelatin and Polycyclodextrin for Prolonging the Shelf Life of Tyrosinase Enzyme","authors":"Shaghayegh Vakili , Hamed Azadfar , Ebrahim Ahmadi , Zahra Mohamadnia , Atiyeh Mahdavi , Faezeh Hanifeh","doi":"10.1021/acs.biomac.5c00346","DOIUrl":"10.1021/acs.biomac.5c00346","url":null,"abstract":"<div><div>Here, a self-healing hydrogel was designed and synthesized to immobilize tyrosinase enzyme (Tyr), addressing the need for improved enzyme performance. The self-healing properties of the hydrogel ensured structural integrity, while its enzyme immobilization capability significantly enhanced enzyme stability and activity. The hydrogel was synthesized via host–guest interactions between polycyclodextrin (PCD) and aminoazobenzene-modified gelatin (Gel-AZO), and chemically cross-linked in the presence of glycidyl methacrylate-modified gelatin (GM-Gelatin) and acryloyloxyethyltrimethylammonium chloride (DAC) to form a dual-network structure. The immobilized enzyme retained 94.56% of the free enzyme’s activity and remained stable under varying pH and temperatures, maintaining 70% activity at 70 °C. Reusability tests showed preserved enzymatic activity over six cycles. The hydrogel exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli, maintained cell viability above 80%, and showed hemolytic activity below 5%. These results highlight the potential applicability of this self-healing hydrogel in biomedical and industrial settings that require stable enzymatic performance.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (249KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4364-4379"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Self-Assembled Piezoelectric Films from Aligned Lysozyme Protein Fibrils". 修正“从排列的溶菌酶蛋白原纤维自组装压电薄膜”。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 Epub Date: 2025-06-02 DOI: 10.1021/acs.biomac.5c00774

Donn Adam D Gito, Alireza Akbarinejad, Alexander Dixon, Thomas Loho, Michel Nieuwoudt, Qun Chen, Laura J Domigan, Jenny Malmström