Biomacromolecules最新文献_第9页

Construction of Nanohydroxyapatite/Poly(sodium lipoate)-Based Bioactive Hydrogels for Cranial Bone Regeneration. 纳米羟基磷灰石/聚脂酸钠基颅骨再生生物活性水凝胶的构建。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-28 DOI: 10.1021/acs.biomac.4c01584

Jiaqiang Du, Tingting Chen, Jing Yu, Yilong Cheng

{"title":"Construction of Nanohydroxyapatite/Poly(sodium lipoate)-Based Bioactive Hydrogels for Cranial Bone Regeneration.","authors":"Jiaqiang Du, Tingting Chen, Jing Yu, Yilong Cheng","doi":"10.1021/acs.biomac.4c01584","DOIUrl":"10.1021/acs.biomac.4c01584","url":null,"abstract":"Persistent oxidative stress following bone defects significantly impedes the repair of bone tissue. Designing an antioxidative hydrogel with a suitable mechanical strength can help alter the local microenvironment and promote bone defect healing. In this work, α-lipoic acid (LA), a natural antioxidant small molecule, was chemically cross-linked with lipoic acid-functionalized poly(ethylene glycol) (PEGx, x = 6k or 10k) in sodium bicarbonate solution, to prepare LA-PEGx hydrogels (LPx, x = 6k or 10k). Furthermore, nanohydroxyapatite (nHA)-LA-PEGx (HLPx, x = 6k) hydrogels were constructed through incorporating nHA. The hydrogels exhibited moderate mechanical strength, facile injectability, self-healability, adhesion, biodegradability, biocompatibility, and promising antioxidation efficiency. We verify the advantage of the HLP6k-3 hydrogel in a rat cranial defect model. Through the regulation of reactive oxygen species (ROS), osteoconduction, and biomineralization capabilities, our system can promote new bone formation. Overall, bioactive hydrogels with multiple functions hold significant promise for repairing bone defects.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"705-714"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning Star Polymer Architecture to Tailor Secondary Structures and Mechanical Properties of Diblock Polypeptide Hydrogels for Direct Ink Writing. 调整星形聚合物结构以定制用于直接墨水书写的二嵌段多肽水凝胶的二级结构和力学性能。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-19 DOI: 10.1021/acs.biomac.4c01500

Muireann Cosgrave, Kulwinder Kaur, Christopher Simpson, Łukasz Mielańczyk, Ciara Murphy, Robert D Murphy, Andreas Heise

{"title":"Tuning Star Polymer Architecture to Tailor Secondary Structures and Mechanical Properties of Diblock Polypeptide Hydrogels for Direct Ink Writing.","authors":"Muireann Cosgrave, Kulwinder Kaur, Christopher Simpson, Łukasz Mielańczyk, Ciara Murphy, Robert D Murphy, Andreas Heise","doi":"10.1021/acs.biomac.4c01500","DOIUrl":"10.1021/acs.biomac.4c01500","url":null,"abstract":"Hydrogel three-dimensional (3D) printing has emerged as a highly valuable fabrication tool for applications ranging from electronics and biomedicine. While conventional hydrogels such as gelatin, alginate, and hyaluronic acid satisfy biocompatibility requirements, they distinctly lack reproducibility in terms of mechanical properties and 3D printability. Aiming to offer a high-performance alternative, here we present a range of amphiphilic star-shaped diblock copolypeptides of l-glutamate and l-leucine residues with different topologies. Hydrophobic side chains of the l-leucine polymer block drive conformational self-assembly in water, spontaneously forming hydrogels with tunable mechanical properties, through variation of star topology. Their amenable shear-thinning and self-recovery properties render them suitable as hydrogel inks for direct ink writing. Well-defined 3D-printed structures can be readily generated and rapidly photo-cross-linked using visible light (405 nm) after methacrylamide functionalization, while hydrogel inks demonstrate good biocompatibility with top-seeded and encapsulated MC3T3 cells.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"670-678"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

X-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy. x射线触发活化多肽药物协同放化疗。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-27 DOI: 10.1021/acs.biomac.4c01373

Yufei Cao, Moujiang Zheng, Jiahong Shi, Jiale Si, Guopu Huang, Yuanyuan Ji, Yuzhu Hou, Zhishen Ge

{"title":"X-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy.","authors":"Yufei Cao, Moujiang Zheng, Jiahong Shi, Jiale Si, Guopu Huang, Yuanyuan Ji, Yuzhu Hou, Zhishen Ge","doi":"10.1021/acs.biomac.4c01373","DOIUrl":"10.1021/acs.biomac.4c01373","url":null,"abstract":"X-ray-induced photodynamic therapy (XPDT) can penetrate deeply into the tumor tissues to overcome the disadvantage of conventional PDT. However, the therapeutic efficacy of XPDT in cancer therapy is still restricted due to the insufficient reactive oxygen species (ROS) generation at a relatively low irradiation dosage. Herein, we present the tumor pH and ROS-responsive polyprodrug micelles to load the X-ray photosensitizer verteporfin (VP) as an ROS production enhancer. The block copolymer polyprodrug consisting of hydrophilic poly(ethylene glycol) (PEG) as well as the segments of thioketal-linked camptothecin (CPT) methacrylate (CPTKMA) and 2-(pentamethyleneimino)ethyl methacrylate (PEMA) (PEG-b-P(CPTKMA-co-PEMA)) can self-assemble into micelles in aqueous solution and encapsulate VP with a high loading efficiency of 67%. Inside tumor tissues, the zeta potential of the micelles can transform from neutral to positive for promoted cellular internalization under tumor acidity. Followed by X-ray irradiation at the dose of 4 Gy, efficient ROS generation in the presence of VP triggers CPT release. The VP-loaded polyprodrug micelles can finally ablate tumors efficiently via synergistic radiochemotherapy due to deep penetration of X-ray inside tumor tissues, ROS generation enhancement, and triggered CPT release. Consequently, this promising strategy represents a robust therapeutic modality for the enhanced radiochemotherapy of cancers.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"579-590"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Performance Triple-Network Hydrogels Derived from Chrome Leather Scraps: Ultrahigh Compressive Strength, Adhesion, and Self-Recovery. 高性能三网水凝胶源自铬皮革废料：超高抗压强度，附着力和自我恢复。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-16 DOI: 10.1021/acs.biomac.4c01538

Jingjing Ren, Bin Lyu, Dangge Gao, Yatong Fu, Jianzhong Ma

{"title":"High-Performance Triple-Network Hydrogels Derived from Chrome Leather Scraps: Ultrahigh Compressive Strength, Adhesion, and Self-Recovery.","authors":"Jingjing Ren, Bin Lyu, Dangge Gao, Yatong Fu, Jianzhong Ma","doi":"10.1021/acs.biomac.4c01538","DOIUrl":"10.1021/acs.biomac.4c01538","url":null,"abstract":"The development of engineered hydrogels with high strength, self-recovery, and adhesion is essential for applications requiring resistance to large deformations and cyclic loading. Herein, a triple-network (TN) hydrogel with ultrahigh compressive strength, strong adhesion, and good self-recovery was constructed by using tannic acid-modified chrome leather scrap hydrolysate as the first network, polyacrylamide as the second network, and poly-2-propenamide-2-methylpropanesulfonic acid as the third network. The ultrahigh (70 MPa compressive strength and 95% compression deformation) TN hydrogels were effectively created, which is attributed to the synergy of the three networks. The TN hydrogels display adhesion (adhesion strength > 20 kPa) ascribed to the introduction of phenolic hydroxyl groups in tannic acid. Intriguingly, the TN hydrogels exhibit excellent self-recovery performance (93.6% dissipated energy recovery at 70 °C) and shape memory performance (restored to the original shape in 20 s). These properties are essential for the development of high-performance hydrogels and promote the resource utilization of leather waste.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"679-688"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic Acid-Based pH-Sensitive Nanogel: Synthesis, Characterization, and Assessment for Acyclovir Delivery In Vitro and In Vivo. 基于透明质酸的ph敏感纳米凝胶：合成、表征和体外和体内给药阿昔洛韦的评估。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-25 DOI: 10.1021/acs.biomac.4c01189

Aalaa K Moussa, Heba A Abd El-Rahman, Riham R Mohamed, Demiana H Hanna

引用次数: 0

Enhanced Tunability of Photo-Cross-Linkable Silk Sericins from Bombyx mori. 家蚕光交联丝素的增强可调性。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-02 DOI: 10.1021/acs.biomac.4c00975

Nicolas Deroose, Laurens Parmentier, Bart Devreese, Peter Dubruel

{"title":"Enhanced Tunability of Photo-Cross-Linkable Silk Sericins from Bombyx mori.","authors":"Nicolas Deroose, Laurens Parmentier, Bart Devreese, Peter Dubruel","doi":"10.1021/acs.biomac.4c00975","DOIUrl":"10.1021/acs.biomac.4c00975","url":null,"abstract":"Over the past decade, silk sericin has emerged as a promising material for biomedical applications, especially in tissue engineering, where fine-tuning the physicochemical properties is crucial. However, previous studies, including those on the methacrylation of sericin (yielding SS-MA), showed limited tunability. Here, we developed a photo-cross-linkable sericin-based material modified with 2-aminoethyl methacrylate (AEMA) using two synthesis routes: sequential modification of SS-MA with AEMA (SS-MA-AEMA) and an efficient one-pot synthesis (SS-AEMA). The one-pot synthesis yielded materials containing only methacrylate groups, unlike the sequential modification that yielded a combination of methacrylamides and methacrylates. Our approach resulted in superior physicochemical properties. The resulting materials, including the previously described SS-MA, exhibited a broad range of properties, such as cross-linking kinetics (0.9-64.0 s), swelling behavior (311-3775%), and mechanical properties (10-140 kPa). These properties support applications across various tissues, from dermis to fibrous tissue. The materials also demonstrated fibroblast cytocompatibility with cell viabilities exceeding 96%.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"222-237"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking the Bone Extracellular Matrix through a Calcium Phosphate-Containing Thiol-Ene Cross-Linked Gelatin Composite. 通过含磷酸钙的硫醇-炔交联明胶复合材料模拟骨细胞外基质

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-16 DOI: 10.1021/acs.biomac.4c01182

Laurens Parmentier, Sophie D'Haese, Louis Van der Meeren, Anna Szabó, Andre G Skirtach, Ruslan I Dmitriev, Janis Locs, Sandra Van Vlierberghe

{"title":"Mimicking the Bone Extracellular Matrix through a Calcium Phosphate-Containing Thiol-Ene Cross-Linked Gelatin Composite.","authors":"Laurens Parmentier, Sophie D'Haese, Louis Van der Meeren, Anna Szabó, Andre G Skirtach, Ruslan I Dmitriev, Janis Locs, Sandra Van Vlierberghe","doi":"10.1021/acs.biomac.4c01182","DOIUrl":"10.1021/acs.biomac.4c01182","url":null,"abstract":"Hydroxyapatite (HAP) and amorphous calcium phosphate (ACP) nanoparticles were incorporated into a thiol-ene clickable gelatin network to elucidate to what extent osteogenic differentiation of human dental pulp- and adipose-derived stem cells (HDPSCs/HASCs) could be further boosted. ACP nanoparticles increased the specific surface area by 23% and reduced the density by 13% while maintaining a comparable particle size (ACP: 25 ± 3 nm; HAP: 27 ± 3 nm). Overall, the incorporation of ceramic nanoparticles did not significantly alter the mechanical properties of the ceramic-containing composites compared to the unsubstituted thiol-ene network. ACP nanoparticles at high concentrations promoted a 21-day osteogenic response in HASCs (72.09 ± 20.20 ng Ca2+/ng DNA) comparable to HDPSCs, with the latter showing high calcium production irrespective of the ceramic content (78.45 ± 10.87 ng Ca2+/ng DNA), suggesting that the provided cues must be optimized according to the investigated cell type toward a cell-interactive coating application stimulating osteogenesis.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"332-340"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk Sericin/Chitosan Supramolecular Multilayered Thin Films as Sustainable Cytocompatible Nanobiomaterials. 作为可持续细胞相容性纳米生物材料的丝胶/壳聚糖超分子多层薄膜

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-16 DOI: 10.1021/acs.biomac.4c01146

Miguel Rosas, Cristiana F V Sousa, Ana Pereira, Adérito J R Amaral, Tamagno Pesqueira, Sónia G Patrício, Sara Fateixa, Helena I S Nogueira, João F Mano, Ana L Oliveira, João Borges

{"title":"Silk Sericin/Chitosan Supramolecular Multilayered Thin Films as Sustainable Cytocompatible Nanobiomaterials.","authors":"Miguel Rosas, Cristiana F V Sousa, Ana Pereira, Adérito J R Amaral, Tamagno Pesqueira, Sónia G Patrício, Sara Fateixa, Helena I S Nogueira, João F Mano, Ana L Oliveira, João Borges","doi":"10.1021/acs.biomac.4c01146","DOIUrl":"10.1021/acs.biomac.4c01146","url":null,"abstract":"Silk sericin (SS) has been widely discarded as a waste by the silk textile industry during the degumming process to obtain fibroin. However, in the past decade, an in-depth understanding of its properties and functions turned it into a high added-value biomaterial for biomedical applications. Herein, we report the molecular design and development of sustainable supramolecular multilayered nanobiomaterials encompassing SS and oppositely charged chitosan (CHT) through a combination of self-assembly and electrostatically driven layer-by-layer (LbL) assembly technology. The successful buildup of SS/CHT multilayered nanobiomaterials was demonstrated by the quartz crystal microbalance with dissipation monitoring and attenuated total reflectance-Fourier transform infrared spectroscopy, and the nanofilms' wettable properties and nanofibrillar-like topography were shown by water contact angle, atomic force microscopy, and scanning electron microscopy. In vitro assays demonstrated the cytocompatibility of the LbL nanofilms toward human primary dermal fibroblasts, holding great promise as biofunctional nanocoatings for drug/therapeutics/cell delivery, tissue engineering, and regenerative medicine.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"296-310"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanofibrous Peptide Hydrogels Leveraging Histidine to Modulate pH-Responsive Supramolecular Assembly and Antibody Release. 利用组氨酸调节ph响应超分子组装和抗体释放的纳米纤维肽水凝胶。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-30 DOI: 10.1021/acs.biomac.4c01296

Gabriel Saenz, Brett H Pogostin, Carson C Cole, Anushka Agrawal, Danielle Chew-Martinez, Marija Dubackic, Antara Pal, Ulf Olsson, Kevin J McHugh, Jeffrey D Hartgerink

{"title":"Nanofibrous Peptide Hydrogels Leveraging Histidine to Modulate pH-Responsive Supramolecular Assembly and Antibody Release.","authors":"Gabriel Saenz, Brett H Pogostin, Carson C Cole, Anushka Agrawal, Danielle Chew-Martinez, Marija Dubackic, Antara Pal, Ulf Olsson, Kevin J McHugh, Jeffrey D Hartgerink","doi":"10.1021/acs.biomac.4c01296","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01296","url":null,"abstract":"In this work, we investigate the pH-responsive behavior of multidomain peptide (MDP) hydrogels containing histidine. Small-angle X-ray scattering confirmed that MDP nanofibers sequester nonpolar residues into a hydrophobic core surrounded by a shell of hydrophilic residues. MDPs with histidine on the hydrophilic face formed nanofibers at all pH values tested, but the morphology of the fibers was influenced by the protonation state and the location of histidine in the MDP sequence. MDPs with histidine residues within the hydrophobic face disassemble below physiological pH and form nanofibers at higher pH. Taking advantage of their stimulus-triggered behavior, an anti-PD-1 antibody was loaded into histidine MDP hydrogels to examine pH-dependent differences in payload delivery in vitro. Hydrogels composed of MDPs with histidine on the hydrophilic face demonstrated pH-dependent payload retention. Additionally, they showed significantly slower antibody release and reduced antibody diffusion rates in vitro compared to MDP hydrogels lacking histidine.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 1","pages":"490-502"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fracture Behavior and Biocompatibility of Cellulose Nanofiber-Reinforced Poly(vinyl alcohol) Composite Hydrogels Cross-Linked with Borax. 硼砂交联纤维素纳米纤维增强聚乙烯醇复合水凝胶的断裂行为和生物相容性。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-08 DOI: 10.1021/acs.biomac.4c01199

Takumi Narita, Wen-Chuan Hsieh, Yu Tzu Ku, Yu-Chieh Su, Hiroki Inoguchi, Hiroyuki Takeno

引用次数: 0