ACS Applied Materials & Interfaces最新文献

Mesoporous Microneedles Enabled Localized Controllable Delivery of Stimulator of Interferon Gene Agonist Nanoexosomes for FLASH Radioimmunotherapy against Breast Cancer 介孔微针实现了干扰素基因激动剂纳米小体的局部可控递送，用于 FLASH 放射免疫疗法治疗乳腺癌

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c09833

Zhiran Chen, Fangjie Hu, Jingfeng Xiang, Xiaoxiang Zhou, Bo Wu, Baohang Fan, Han Tang, Bin Liu, Longyun Chen

{"title":"Mesoporous Microneedles Enabled Localized Controllable Delivery of Stimulator of Interferon Gene Agonist Nanoexosomes for FLASH Radioimmunotherapy against Breast Cancer","authors":"Zhiran Chen, Fangjie Hu, Jingfeng Xiang, Xiaoxiang Zhou, Bo Wu, Baohang Fan, Han Tang, Bin Liu, Longyun Chen","doi":"10.1021/acsami.4c09833","DOIUrl":"https://doi.org/10.1021/acsami.4c09833","url":null,"abstract":"The immunosuppressive nature of the tumor microenvironment (TME) contributes to radioresistance, thereby impairing the effectiveness of radiotherapy as a therapeutic intervention. Activation through the stimulator of interferon genes (STING) pathway shows potential in modulating immunogenicity. However, the therapeutic efficacy of STING agonists might be restricted by off-target effects and potential cytotoxicity. In this work, nanoexosomes (EXOs) loaded within porous microneedles were employed for precise delivery of the STING agonist MSA-2 (MEM) to the tumor site. Leveraging the enhanced tumor penetration enabled by microneedles, EXOs can be continually released and accumulate within deep residual tumors. Once internalized, these EXOs release the encapsulated MSA-2, facilitating the activation of the STING pathway upon exposure to ultrahigh dose-rate (FLASH) irradiation. This strategy elevates the type I interferon level, promotes dendric cell maturation, and modulates the immunosuppressive TME, showing efficient antitumor efficacy in both primary/metastatic tumors. Furthermore, the induction of a potent immune response effectively prevented tumor recurrence. The combination of EXO-loaded microneedles with FLASH radiotherapy resulted in minimal systemic side effects, attributed to precise drug delivery and radioprotection conferred by FLASH. Altogether, the strategic design of EXO-loaded microneedles holds promise for enhancing MSA-2 delivery, thereby mitigating the radioresistant tumor microenvironment through STING cascade activation-mediated immunotherapy, consequently optimizing the outcomes of FLASH radiotherapy.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":9.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Bristle-Structured, Knitted-Fabric-Based Triboelectric Sensors for Machine Learning-Based Motion Recognition 基于机器学习的运动识别三维鬃毛结构针织织物三电传感器

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c12041

Yongwei Li, Jingzhe Sun, Dakyeong Choi, Zihao Zheng, Jong-jin Park, Yong Xiang, Jihyun Bae

{"title":"3D Bristle-Structured, Knitted-Fabric-Based Triboelectric Sensors for Machine Learning-Based Motion Recognition","authors":"Yongwei Li, Jingzhe Sun, Dakyeong Choi, Zihao Zheng, Jong-jin Park, Yong Xiang, Jihyun Bae","doi":"10.1021/acsami.4c12041","DOIUrl":"https://doi.org/10.1021/acsami.4c12041","url":null,"abstract":"With the development of electronic technology, triboelectric-based sensors have been widely researched in fields such as healthcare, rehabilitation training, and sports assistance due to their manufacturing convenience and self-powering advantages. Among them, 3D fabric-based triboelectric sensors not only possess advantages such as easy mechanized production, good breathability, and ease of wearing but also their unique 3D structure enhances the specific surface area, thereby amplifying the sensitivity. This study proposes a 3D bristle-structured fabric made by a digital knitting technology that has not been studied widely for triboelectric devices. By applying the 3D bristle structure with a large specific surface area to the single jersey fabric, the effective contact area during friction can be increased, resulting in a higher surface charge density. Additionally, the microcapacitor-like effect provided by the numerous microstructures allows the device to store more surface charge, further improving the output performance. The study systematically investigates the output performance of four different structures assembled by single jersey and 3D bristle-structured fabrics. The optimal sample exhibits a 57% higher output voltage than that of the reference 2D fabric sample. The 3D bristle-structured fabric demonstrates linear high sensitivity and distinct output performance when used as a sensor. Finally, a machine learning integration is applied to judge motion to assist a baseball pitcher in a self-training system.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":9.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent Tetraphenylethylene-Based Cerium Metal–Organic Frameworks for White-Light-Emitting Diodes 用于白光发光二极管的四苯乙烯基荧光铈金属有机框架

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c14046

Si-Si Zhao, Si-Hui Wang, Qi Sun, Hang Zhang, Jing-Wei Zhao, Xin-Yu Wang, Zhen Zhao

引用次数: 0

Accelerating Discovery of Mechanically Stable Metal–Organic Frameworks for Vinylidene Fluoride Storage by Active Learning 通过主动学习加速发现用于储存偏二氟乙烯的机械稳定金属有机框架

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c14983

Yifei Yue, Athulya S. Palakkal, Saad Aldin Mohamed, Jianwen Jiang

{"title":"Accelerating Discovery of Mechanically Stable Metal–Organic Frameworks for Vinylidene Fluoride Storage by Active Learning","authors":"Yifei Yue, Athulya S. Palakkal, Saad Aldin Mohamed, Jianwen Jiang","doi":"10.1021/acsami.4c14983","DOIUrl":"https://doi.org/10.1021/acsami.4c14983","url":null,"abstract":"Metal–organic frameworks (MOFs) are versatile nanoporous materials for a wide variety of important applications. Recently, a handful of MOFs have been explored for the storage of toxic fluorinated gases (Keasler et al. Science, 2023, 381, 1455), yet the potential of a great number of MOFs for such an environmentally sustainable application has not been thoroughly investigated. In this work, we apply active learning (AL) to accelerate the discovery of hypothetical MOFs (hMOFs) that can efficiently store a specific fluorinated gas, namely, vinylidene fluoride (VDF). First, a force field was developed for VDF and utilized to predict the working capacities (ΔN) of VDF in an initial data set of 4502 MOFs from the computation-ready experimental MOF (CoRE-MOF) database that successfully underwent featurization and grand-canonical Monte Carlo simulations. Next, the initial data set was diversified by Greedy sampling in an unexplored sample space of 119,387 hMOFs from the ab initio REPEAT charge MOF (ARC-MOF) database. A budget of 10,000 samples (i.e., <10% of total ARC-MOFs) was selected to train a random forest model. Then, ΔN in the unlabeled ARC-MOFs were predicted and top-performing ones were validated by simulations. Integrating with the stability requirement, mechanically stable ARC-MOFs were finally identified, along with high ΔN. Furthermore, by Pareto–Frontier analysis, we revealed that long linear linkers can enhance ΔN, while bulkier multiphenyl linkers or interpenetrated frameworks improve mechanical strength. From this work, we efficiently discover top-performing MOFs for VDF storage by AL and also demonstrate the importance of integrating stability to identify stable promising MOFs for a practical application.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":9.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Temperature on Intermediate Phases of Na3V2(PO4)3 during Cycling by Operando X-ray Diffraction 通过 Operando X 射线衍射分析循环过程中温度对 Na3V2(PO4)3 中间相的影响

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c11920

Kriti Choudhary, Sunkyu Park, François Fauth, François Rabuel, Charles Delacourt, Vincent Seznec, Jean-Noël Chotard

{"title":"Effect of Temperature on Intermediate Phases of Na3V2(PO4)3 during Cycling by Operando X-ray Diffraction","authors":"Kriti Choudhary, Sunkyu Park, François Fauth, François Rabuel, Charles Delacourt, Vincent Seznec, Jean-Noël Chotard","doi":"10.1021/acsami.4c11920","DOIUrl":"https://doi.org/10.1021/acsami.4c11920","url":null,"abstract":"Na3V2(PO4)3 (NVP) has gained a lot of attention due to its remarkable properties, such as its robust crystal structure, cycle life, rate capabilities, and so on. Nevertheless, NVP undergoes a substantial decrease in its rate capability at low temperatures, which limits its practical applications. In this study, the performance of NVP at low, room, and high temperatures during cycling is thoroughly investigated using synchrotron operando X-ray diffraction. The (de)insertion of two sodium ions from Na3V2(PO4)3 to Na1V2(PO4)3 appeared to occur via two intermediate phases (Na2V2(PO4)3 and Na1.64V2(PO4)3). The Na1.64V2(PO4)3 phase which is observed for the first-time during operando XRD measurements of NVP, exhibited limited stability at high temperatures. The increase in the quantity of these intermediate phases from high to low temperatures, especially at high C-rates, could be anticipated to be one of the contributing factors of poor rate capabilities of NVP at low temperatures. This study encourages the exploration of suitable strategies to enhance the performance of NVP at low temperatures and high C-rates.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":9.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MgF2 Interface Engineering Promotes the Growth and Stability of LiF-Rich Solid–Electrolyte Interphases on Si-C MgF2 界面工程促进了硅-碳上富锂固体电解质互层的生长和稳定性

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c11705

Peng Liu, Yupeng Xiao, Jiyuan You, Bo Zhang, Tianle Li, Xiaotong Gao, Yuqian Li, Wenju Wang

引用次数: 0

Construction and Performance Study of an Injectable Dual-Network Hydrogel Dressing with Inherent Drainage Function 具有固有引流功能的可注射双网水凝胶敷料的构造和性能研究

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c09483

Xiaoxiao Ma, Lizhi Lin, Kelin Peng, Qianqian Zheng, Yongqiang Feng, Yu Chen

{"title":"Construction and Performance Study of an Injectable Dual-Network Hydrogel Dressing with Inherent Drainage Function","authors":"Xiaoxiao Ma, Lizhi Lin, Kelin Peng, Qianqian Zheng, Yongqiang Feng, Yu Chen","doi":"10.1021/acsami.4c09483","DOIUrl":"https://doi.org/10.1021/acsami.4c09483","url":null,"abstract":"With the widespread utilization of moist wound dressings, the extended healing time and increased risk of wound infection caused by excessively moist environments have garnered significant attention. The development of hydrogel dressings that can effectively control the wound moisture level and promote healing is very important. Inspired by the pore-opening perspiration effect of the skin, this study constructed an injectable dual-network hydrogel, CMCS-OSA/AG/MXene, by the composition of a dynamic covalent network of carboxymethyl chitosan and oxidized sodium alginate based on the Schiff base and hydrogen bond network of the thermosensitive low-melting-point agar with the advantage of the upper critical solution temperature (UCST) effect. Under near-infrared (NIR) light stimulation, the CMCS-OSA/AG/MXene hydrogel shows characteristics conducive to rapid removal of wound exudate while maintaining an appropriate moist environment for the wound and excellent antibacterial effects with its photothermal responses. The excellent conductivity of the hydrogel can also promote cell proliferation under external electrical stimulation (ES). Further validation through animal experiments on a full-thickness skin defect model demonstrates the excellent capability of CMCS-OSA/AG/MXene in accelerating wound healing. This work provides an innovative approach to the development of injectable hydrogel dressing materials with inherent drainage functionality and shows a new avenue to wound moisture control and wound healing promotion.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":9.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing Spatial Molecular Heterogeneity of High-Density Biofunctionalized Surfaces Using DNA-PAINT 利用 DNA-PAINT 揭示高密度生物功能化表面的空间分子异质性

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c10310

Wei Shan Tan, Arthur M. de Jong, Menno W. J. Prins

{"title":"Revealing Spatial Molecular Heterogeneity of High-Density Biofunctionalized Surfaces Using DNA-PAINT","authors":"Wei Shan Tan, Arthur M. de Jong, Menno W. J. Prins","doi":"10.1021/acsami.4c10310","DOIUrl":"https://doi.org/10.1021/acsami.4c10310","url":null,"abstract":"The quantification and control of molecular densities and distributions on biofunctionalized surfaces are key for enabling reproducible functions in biosciences. Here, we describe an analysis methodology for quantifying the density and spatial distribution of high-density biofunctionalized surfaces, with densities in the order of 102–105 biomolecules per μm2 area, in a short measurement time. The methodology is based on single-molecule DNA-PAINT imaging combined with simulation models that compensate for lifetime and spatial undersampling effects, resulting in three distinct molecule counting methods and a statistical test for spatial distribution. The analysis methodology is exemplified for a surface with ssDNA affinity binder molecules coupled to a PLL-g-PEG antifouling coating. The results provide insights into the biofunctionalization efficiency, yield, and homogeneity. Furthermore, the data reveal that heterogeneity is inherent to the biofunctionalization process and shed light on the underlying molecular mechanisms. We envision that DNA-PAINT imaging with the developed analysis framework will become a versatile tool to study spatial heterogeneity of densely biofunctionalized surfaces for a wide range of applications.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":9.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferrimagnet-Based Neuromorphic Device Mimicking the Ventral Visual Pathway for High-Accuracy Target Recognition 基于铁磁体的神经形态设备模仿腹侧视觉通路实现高精度目标识别

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c13405

Junwei Zeng, Yabo Chen, Jiahao Liu, Teng Xu, Liang Fang, Yang Guo

{"title":"Ferrimagnet-Based Neuromorphic Device Mimicking the Ventral Visual Pathway for High-Accuracy Target Recognition","authors":"Junwei Zeng, Yabo Chen, Jiahao Liu, Teng Xu, Liang Fang, Yang Guo","doi":"10.1021/acsami.4c13405","DOIUrl":"https://doi.org/10.1021/acsami.4c13405","url":null,"abstract":"The ventral visual pathway (VVP) of the human brain efficiently implements target recognition by employing a deep hierarchical structure to build complex visual concepts from simple features. Artificial neural networks (ANNs) based on spintronic devices are capable of target recognition, but their poor interpretability and limited network depth hinder ANNs from mimicking the VVP. Hardware implementation of the VVP requires a biorealistic spintronic device as well as the corresponding interpretable and deep network structure, which have not been reported so far. Here, we report a ferrimagnetic neuron with a continuously differentiable exponential linear unit (CeLu) activation function, which is closer to biological neurons and could mitigate the issue of limited network depth. Meanwhile, we also demonstrate that a ferrimagnet can construct artificial synapses with high linearity and symmetry to meet the requirements of weight update algorithms. Based on these neurons and synapses, we propose an all-spin convolutional neural network (CNN) with a high interpretability and deep neural network, to mimic the VVP. Compared to the state-of-the-art spintronic-based neuromorphic computing model, the CNN with bionic function, using experimentally derived device parameters, achieves high recognition accuracies of over 91% and 98% on the CIFAR-10 datasets and the MNIST datasets, respectively, showing improvements of 1.13% and 1.76%. Our work provides a promising method to improve the bionic performance of spintronic device-based neural networks.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":9.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Weighted Mobility Induced High Thermoelectric Performance in Argyrodite Ag8SnSe6 增强加权迁移率诱导 Argyrodite Ag8SnSe6 的高热电性能

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-10-21 DOI: 10.1021/acsami.4c14311

Siqi Lin, Yuzhu Hou, Ju Yang, Pengfei Fan, Shoumei Liu, Linlin Guo, Min Jin

{"title":"Enhanced Weighted Mobility Induced High Thermoelectric Performance in Argyrodite Ag8SnSe6","authors":"Siqi Lin, Yuzhu Hou, Ju Yang, Pengfei Fan, Shoumei Liu, Linlin Guo, Min Jin","doi":"10.1021/acsami.4c14311","DOIUrl":"https://doi.org/10.1021/acsami.4c14311","url":null,"abstract":"The argyrodite family has emerged as a promising thermoelectric candidate due to its highly diffusive Ag ions and inherent low thermal conductivity. To address issues that commonly arise with hot pressing (HP) sintering, this study proposes to use the zone melting (ZM) method to synthesize high-density polycrystalline bulk Ag8SnSe6 samples. The thermoelectric properties of samples synthesized by the ZM and HP methods were thoroughly evaluated over a temperature range of 300 to 700 K. Due to the weaker scattering of electrons, the ZM-synthesized samples exhibited an ∼60% increase in weighted mobility, compared to those produced by the HP method. Despite the slight increase in thermal conductivity, the specimen synthesized by the ZM method achieves a higher peak zT value of 1.05 at 700 K. The average zT value also improves to 0.71 across the temperature range of 300 to 700 K. This work demonstrates the effectiveness of the ZM method in enhancing the thermoelectric performance of Ag8SnSe6, with great potential applicability to other argyrodite compounds.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":9.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0