ACS Applied Materials & Interfaces最新文献_第2页

VYQFF Peptide-Modified Brucine Liposomes: Antitumor Activity in Head and Neck Squamous Cell Carcinoma and Mechanistic Insights VYQFF肽修饰的马钱子碱脂质体：头颈部鳞状细胞癌的抗肿瘤活性及其机制见解

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-12 DOI: 10.1021/acsami.6c15023

Rixin Su, Runjing Li, Xiaorui Wu, Jie Xiong, Jia Jin, Xueling Zhang, Banglong Song, Yu Zhang, Ping Li

{"title":"VYQFF Peptide-Modified Brucine Liposomes: Antitumor Activity in Head and Neck Squamous Cell Carcinoma and Mechanistic Insights","authors":"Rixin Su, Runjing Li, Xiaorui Wu, Jie Xiong, Jia Jin, Xueling Zhang, Banglong Song, Yu Zhang, Ping Li","doi":"10.1021/acsami.6c15023","DOIUrl":"10.1021/acsami.6c15023","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat, and conventional chemotherapy has limited efficacy and substantial toxicity. We developed a VYQFF peptide-modified brucine liposome (Bru-VYQFF-Lip) and characterized its particle size, zeta potential, polydispersity, encapsulation efficiency, and drug loading. Bru-VYQFF-Lip showed greater uptake in Trop2-high HSC3 cells than in HOK cells and inhibited HNSCC-cell proliferation, migration, and invasion while promoting apoptosis. After intratumoral administration, the VYQFF-modified formulation showed greater local fluorescence retention than the NHS-bearing, non-peptide comparator; this experiment does not establish systemic tumor targeting or direct Trop2-specific recognition. Bru-VYQFF-Lip also suppressed tumor growth in a nude-mouse xenograft model. Terminal serum chemistry and organ histology did not reveal overt hepatorenal or histopathological injury, although the safety assessment was limited by the absence of complete longitudinal and hematological evaluation. Bioinformatic and experimental analyses identified INHBA as a candidate mediator associated with poor prognosis. Mechanistic experiments were consistent with suppression of the INHBA/TGF-β/Smad axis and epithelial-mesenchymal transition. These findings support further evaluation of VYQFF-functionalized brucine liposomes, including physicochemically matched controls, receptor-blocking studies, systemic biodistribution experiments, and comprehensive toxicology.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55946–55961"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled Edge-Mediated Photoelectrochemical Thinning and Patterning of Transition Metal Dichalcogenides 过渡金属二硫族化合物控制边缘介导的光电化学减薄和图案化

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 DOI: 10.1021/acsami.6c16021

Simon Wörle,Lukas M. Wolz,Sergej Levashov,Saerom Lim,Franz Gröbmeyer,Maximilian Christis,Claudia Paulus,Emiliano Cortés,Jonathan J. Finley,Johanna Eichhorn,Jeremy T. Robinson,Ian D. Sharp

{"title":"Controlled Edge-Mediated Photoelectrochemical Thinning and Patterning of Transition Metal Dichalcogenides","authors":"Simon Wörle,Lukas M. Wolz,Sergej Levashov,Saerom Lim,Franz Gröbmeyer,Maximilian Christis,Claudia Paulus,Emiliano Cortés,Jonathan J. Finley,Johanna Eichhorn,Jeremy T. Robinson,Ian D. Sharp","doi":"10.1021/acsami.6c16021","DOIUrl":"https://doi.org/10.1021/acsami.6c16021","url":null,"abstract":"Transition metal dichalcogenides (TMDs) are widely investigated for electrochemical and photoelectrochemical energy conversion applications, yet the oxidation processes that govern their stability in reactive electrolytes remain poorly understood. Here, we systematically compare dark electrochemical and illuminated photoelectrochemical anodic etching and thinning of mechanically exfoliated MoS2, WS2, MoSe2, and WSe2 flakes as a function of applied potential, electrolyte pH, irradiance, and oxidation time. In the dark, oxidation initiates at defect-rich flake edges and produces lateral etching without appreciable basal-plane thinning. The oxidation peak potentials exhibit significantly different pH dependences for sulfide- and selenide-based TMDs, revealing chalcogen-dependent oxidation chemistry and kinetics. Under illumination, an additional oxidation regime emerges at lower anodic potentials, in which multilayer n-type MoS2, WS2, and MoSe2 undergo vertical thinning with minimal lateral etching, whereas no thinning is observed for p-type WSe2. This observation, together with strong suppression of thinning by sacrificial hole acceptors, indicates that photogenerated holes accumulated in the upper layers of n-type TMDs drive a photoelectrochemical self-oxidation process. Tuning the bias, irradiance, and oxidation time enables controlled conversion of initially nonuniform multilayer flakes into homogeneous few-layer structures, while focused laser excitation yields spatially localized thinning and patterning. In addition to elucidating stability windows and oxidation mechanisms of TMD photoelectrodes, these results provide a versatile strategy for controllably tuning the thickness and morphology of layered semiconductors.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"56 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

La Doping Imparts Bifunctional Interfacial Catalysis for Dehydrolactonization of 1,6-Hexanediol La掺杂对1,6-己二醇脱氢内酯的双功能界面催化作用

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 DOI: 10.1021/acsami.6c16892

Zheng Wang,Wanli Wang,Jingming Bao,Mingwei Yang,Xubin Zhang,Yongwang Li,Bingxin Zhu,Jiaxing Zhang,Xingtao Wang,Zhiwei Zhang,Tianlei Wang,Fumin Wang

{"title":"La Doping Imparts Bifunctional Interfacial Catalysis for Dehydrolactonization of 1,6-Hexanediol","authors":"Zheng Wang,Wanli Wang,Jingming Bao,Mingwei Yang,Xubin Zhang,Yongwang Li,Bingxin Zhu,Jiaxing Zhang,Xingtao Wang,Zhiwei Zhang,Tianlei Wang,Fumin Wang","doi":"10.1021/acsami.6c16892","DOIUrl":"https://doi.org/10.1021/acsami.6c16892","url":null,"abstract":"The dehydrolactonization of 1,6-hexanediol (1,6-HDO) to ε-caprolactone (ε-CL) requires a catalyst capable of cooperatively catalyzing two distinct half-reactions, namely dehydrogenation and cyclization. However, conventional catalysts lack the electronically asymmetric sites needed to drive both steps efficiently. Herein, a bifunctional Cu+–Ov–Ce3+ interfacial frustrated Lewis pair (FLP) is constructed by loading Cu onto La doping CeO2. La doping introduces additional oxygen vacancies (Ov) and Ce3+ species, thereby enriching the Ov–Ce3+ sites. Systematic characterizations (XPS, EPR, XAS, TPD, in situ FTIR) combined with DFT calculations reveal that Cu+ sites are responsible for α-H elimination to form 6-hydroxyhexanal (6-HA), whereas the cyclization reaction is driven by the FLP composed of Ov–Ce3+ and adjacent lattice oxygen. La incorporation lowers the energy barrier and enhances FLP formation. Under optimized conditions (3 wt % La, 280 °C, weight hourly space velocity of 1.5 h–1), a ε-CL yield of 61.17% is achieved with good stability over 120 h. From these findings, the interfacial bifunctional mechanism is clearly elucidated, and a defect engineering strategy for decoupling interfacial components is demonstrated, providing a rational approach to the design of multifunctional catalysts for tandem reactions.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"233 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron Site Evolution in Fe-MFI Zeolite under Thermal Treatment: Spectroscopic Insights and Acetone Vapor Interactions 热处理下Fe-MFI沸石中铁位点的演化：光谱分析和丙酮蒸气相互作用

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 DOI: 10.1021/acsami.6c16279

Igor Gomes,Rita Abreu,Arkaitz Fidalgo Marijuan,Nelson Pereira,José S. Garitaonandia,Ricardo Simoes,Joaquim Alexandre S. A. Oliveira Carneiro,Senentxu Lanceros-Méndez,Stanislav Ferdov,Carlos M. Costa

{"title":"Iron Site Evolution in Fe-MFI Zeolite under Thermal Treatment: Spectroscopic Insights and Acetone Vapor Interactions","authors":"Igor Gomes,Rita Abreu,Arkaitz Fidalgo Marijuan,Nelson Pereira,José S. Garitaonandia,Ricardo Simoes,Joaquim Alexandre S. A. Oliveira Carneiro,Senentxu Lanceros-Méndez,Stanislav Ferdov,Carlos M. Costa","doi":"10.1021/acsami.6c16279","DOIUrl":"https://doi.org/10.1021/acsami.6c16279","url":null,"abstract":"Iron-containing MFI zeolites (Fe-MFI) and purely siliceous MFI were compared to assess the structural and electronic effects of iron incorporation. Powder X-ray diffraction confirms that the MFI framework is preserved after Fe introduction during synthesis. UV–vis and 57Fe Mössbauer spectroscopy show that iron is mainly present as Fe3+ in distorted [5]/[6]-coordinated and octahedral environments. In the as-synthesized material, Fe3+ accounts for ∼88% of the total iron, accompanied by a minor Fe2+ fraction (13%). After calcination, Fe2+ is fully oxidized to Fe3+ and redistributed nearly equally between distorted and octahedral sites. Nitrogen physisorption indicates a moderate loss of microporosity due to the partial pore occupation by FeOx species. Overall, Fe incorporation generates dispersed Fe3+ centers and small extra-framework FeOx species that subtly modify the structural and electronic properties of the MFI zeolite. These powders were incorporated into a membrane for acetone vapor detection, the Fe-MFI membrane showing a stronger and more distinct response to acetone exposure than the pure MFI membrane. In summary, this study establishes Fe-MFI membranes as promising active materials for acetone vapor interaction, providing a robust proof-of-concept for future gas-sensing applications. The key novelty of this work is the direct correlation between the calcination-induced redistribution of iron sites and the resulting vapor-sensing performance of the membrane.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"94 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Thermoelectric Power Modules Employing n-Type Ag2Se Synthesized via a Sustainable Route 可持续合成n型Ag2Se先进热电功率模块

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 DOI: 10.1021/acsami.6c16959

Omer Faruk Donmez,Aminu Yusuf,Bejan Hamawandi,Muharrem Acerce,Kaspars Pudzs,Muhammet S. Toprak,Sedat Ballikaya

{"title":"Advanced Thermoelectric Power Modules Employing n-Type Ag2Se Synthesized via a Sustainable Route","authors":"Omer Faruk Donmez,Aminu Yusuf,Bejan Hamawandi,Muharrem Acerce,Kaspars Pudzs,Muhammet S. Toprak,Sedat Ballikaya","doi":"10.1021/acsami.6c16959","DOIUrl":"https://doi.org/10.1021/acsami.6c16959","url":null,"abstract":"Thermoelectric (TE) Ag2Se was synthesized via an energy-efficient, solution-based chemical synthesis route with microwave-assisted heating and compacted by sustainable cold pressing. Structural and TE transport property analyses confirmed a highly crystalline microstructure that promotes high electrical conductivity, a large Seebeck coefficient, and low thermal conductivity, yielding a peak TE figure of merit (ZT) of ∼0.85 at room temperature. To evaluate device-level performance, Ag2Se was employed as the n-type TE leg in modules paired with Sb1.5Bi0.5Te3 (ZT ∼1.1 at 325 K) as the complementary p-type TE leg. Both rigid and flexible modules, each containing 58 thermocouple pairs, were fabricated and benchmarked against a commercial TEC1-12706 module. The rigid module exhibited more than four times the maximum power output of the commercial reference, highlighting the promise of Ag2Se for low-temperature TE power applications. Cooling performance tests demonstrated the critical influence of electrical configuration. Series-connected rigid modules achieved the lowest cold-side temperatures at lower input power, reaching ∼2 °C at 18 W, comparable to or exceeding the cooling performance of the commercial device. In contrast, parallel-connected modules exhibited stronger initial cooling but were hindered by excessive current draw, Joule heating, and thermal instability, preventing stable saturation. Increasing input power would enhance cooling performance until saturation limits were reached. These results emphasize the importance of module architecture and thermal management for optimizing TE device performance. Overall, this work establishes Ag2Se as a promising alternative to conventional Bi-Sb-Te-based n-type materials, demonstrating versatility in both rigid and flexible TE modules for energy harvesting and cooling technologies.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"124 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomembrane-Camouflaged Stents: Promising Strategies for Advanced Coronary Interventions 生物膜伪装支架：先进冠状动脉介入治疗的有前途的策略

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 DOI: 10.1021/acsami.6c11806

Junyan Zhang,Sibei Tao,Jiaojiao Yang,Ping Fu,Zhongxiu Chen,Li Rao,Siying Tao,Yong He

{"title":"Biomembrane-Camouflaged Stents: Promising Strategies for Advanced Coronary Interventions","authors":"Junyan Zhang,Sibei Tao,Jiaojiao Yang,Ping Fu,Zhongxiu Chen,Li Rao,Siying Tao,Yong He","doi":"10.1021/acsami.6c11806","DOIUrl":"https://doi.org/10.1021/acsami.6c11806","url":null,"abstract":"Coronary stent implantation remains a cornerstone therapy for coronary artery disease, yet current stent technologies continue to face limitations including acute and late thrombosis, delayed re-endothelialization, chronic inflammation, and in-stent restenosis. These complications largely arise from the nonphysiological interface between the implanted device and the injured vascular microenvironment. Biomembrane-camouflaged stents have recently emerged as a promising strategy to engineer biologically instructive blood-contacting surfaces by integrating natural or artificial membrane systems onto stent platforms. In this review, we summarize recent advances in three major biomembrane-based strategies for coronary stent functionalization: cell membrane-camouflaged stents, liposome-camouflaged stents, and exosome-camouflaged stents. Biomimetic cell membrane coatings retain native bioactive signals that collectively facilitate immune evasion, thromboresistance, and vascular healing. Liposome-based coatings are tunable artificial biomembrane reservoirs for the localized delivery of anticoagulants, anti-inflammatories, nitric oxide releasers, antiproliferatives, and gene therapies. Exosome-functionalized stents further enable bioactive intercellular communication by transferring endogenous regulatory cargos that modulate endothelial regeneration, macrophage polarization, smooth muscle cell phenotype, oxidative stress, and neointimal remodeling. We further discuss fabrication approaches, biological mechanisms, preclinical evidence, translational barriers, and future design principles for these platforms. Although challenges remain in coating durability, sterilization, long-term storage, manufacturing reproducibility, and clinical validation, biomembrane-camouflaged stents represent a compelling direction for next-generation coronary intervention by transforming conventional stents from passive mechanical scaffolds into active regulators of vascular repair.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"24 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Molecule Multifunctional Additive Enables Coupled Solvation and Interphase Engineering for Highly Reversible Zinc Anodes 单分子多功能添加剂实现了高可逆锌阳极的耦合溶剂化和界面工程。

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-08 DOI: 10.1021/acsami.6c09786

Bei Yan, Yue Fei, Xiaoyu Xia, Yue Li, Yuxuan Wu, Hao Zhang, Ge Li

{"title":"Single-Molecule Multifunctional Additive Enables Coupled Solvation and Interphase Engineering for Highly Reversible Zinc Anodes","authors":"Bei Yan, Yue Fei, Xiaoyu Xia, Yue Li, Yuxuan Wu, Hao Zhang, Ge Li","doi":"10.1021/acsami.6c09786","DOIUrl":"10.1021/acsami.6c09786","url":null,"abstract":"Dendritic formation and parasitic interfacial reactions occurring on the zinc anode remains a major obstacle to the commercialization of aqueous zinc-ion batteries. Rational electrolyte additive design offers an effective route to move beyond single-function regulation toward synergistic multimechanism control. Compared to multicomponent systems, single-molecule additives with multiple functional groups enable integrated control over solvation structure and interfacial chemistry while reducing complexity and cost. Herein, the natural amino acid hydroxyproline (hyp) is introduced as a multifunctional electrolyte additive for simultaneous regulation of the Zn2+ solvation and interfacial chemistry. The −COOH and −OH groups reconstruct the solvation sheath and hydrogen-bond network, while the −NH− group promotes interfacial adsorption and induces a compact, N-rich interphase that homogenizes Zn2+ flux and suppresses dendrite growth. Benefiting from this cooperative solvation−interphase regulation, stable Zn plating/stripping is achieved for over 2000 h in Zn//Zn cells, an average coulombic efficiency of 99.79% is maintained over 1500 cycles in Zn//Cu cells, and Zn//LiFePO4 full cells deliver a capacity of 154 mAh g−1 over 500 cycles at 0.2 A g−1. This work highlights single-molecule, multifunctional electrolyte additive engineering as a rational, scalable strategy for durable, safe aqueous zinc batteries.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56038–56047"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton-Exchange Surface Engineering Enables Air-Stable Sodium Layered Oxide Cathodes for Carbon-Neutral Energy Storage 质子交换表面工程使空气稳定的钠层状氧化物阴极用于碳中性储能。

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-08 DOI: 10.1021/acsami.6c16266

Lin Huangfu, Le Tong, Yiming Zhang, Xing Shen, Xiaoping Jiang, Baihua Qu, Chaohe Xu, Jingfeng Wang

{"title":"Proton-Exchange Surface Engineering Enables Air-Stable Sodium Layered Oxide Cathodes for Carbon-Neutral Energy Storage","authors":"Lin Huangfu, Le Tong, Yiming Zhang, Xing Shen, Xiaoping Jiang, Baihua Qu, Chaohe Xu, Jingfeng Wang","doi":"10.1021/acsami.6c16266","DOIUrl":"10.1021/acsami.6c16266","url":null,"abstract":"O3-type layered oxides have emerged as one of the most promising cathode candidates for sodium-ion batteries, which are widely regarded as a key enabling technology for carbon-neutral grid-scale energy storage. However, their practical application is hindered by surface degradation upon air exposure and structural distortion from Mn3+. Herein, we develop a two-step surface engineering protocol that combines proton-exchange washing with a short postcalcination to treat O3-type cathodes. Proton-exchange treatment removes surface carbonates and oxidizes Mn3+ to widen the interlayers for enhanced Na+ diffusion and Jahn–Teller suppression, while the subsequent short calcination heals residual defects and locks in the refined structure. The optimally treated Na0.82Cu0.19Fe0.39Mn0.42O2 cathode delivers a reversible capacity of 110.2 mAh g–1 at 0.2 C with 92.3% retention after 100 cycles (substantially outperforming the pristine sample at 48.6%), while retaining its superior performance even after one month of air exposure. This cost‑effective and scalable surface engineering approach thus removes a critical industrial bottleneck for sodium‑ion batteries, marking a tangible step toward sustainable storage technologies for the zero‑carbon transition.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56192–56202"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149133988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioengineered Hybrid Nanovesicles Modulate the Immune Microenvironment with Targeted Drug Delivery for Esophageal Squamous Cell Carcinoma Therapy 生物工程杂交纳米囊泡通过靶向药物递送调节免疫微环境用于食管鳞状细胞癌治疗

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-10 DOI: 10.1021/acsami.6c14588

Fei Xie, Lulu Feng, Yuting Wang, Chaofan Huang, Chenlong Wang, Chao Luo, Li Zhang, Congyong Sun, Qilong Wang

{"title":"Bioengineered Hybrid Nanovesicles Modulate the Immune Microenvironment with Targeted Drug Delivery for Esophageal Squamous Cell Carcinoma Therapy","authors":"Fei Xie, Lulu Feng, Yuting Wang, Chaofan Huang, Chenlong Wang, Chao Luo, Li Zhang, Congyong Sun, Qilong Wang","doi":"10.1021/acsami.6c14588","DOIUrl":"10.1021/acsami.6c14588","url":null,"abstract":"Combining chemotherapy and immunotherapy shows great promise for treating esophageal squamous cell carcinoma (ESCC), but its effectiveness is hindered by the immunosuppressive tumor environment and challenges in drug delivery. Recent research has focused on cell membrane-coated nanoparticles for targeted drug delivery, leveraging their ability to evade the immune system while selectively targeting tumor cells. In this study, we developed a biomimetic hybrid nanoplatform based on cell membranes to combine molecular chemotherapy and improve the effectiveness of immunochemotherapy in treating ESCC. The nanoplatform is coated with a membrane fusion of activated neutrophils and ESCC cells and loaded with paclitaxel (PTX) and small interfering RNA targeting EFNA1 (siEFNA1), a molecule linked to ESCC metastasis. By exploiting the homologous targeting properties of ESCC cell membranes and the tumor-homing ability of neutrophil membranes, the platform effectively targets ESCC tissues and delivers siEFNA1 and PTX. This allows for a synergistic treatment approach, combining EFNA1 gene silencing with PTX-induced cytotoxicity to target ESCC more effectively. Crucially, the nanoplatform reprograms tumor-associated macrophages from the pro-tumor M2 phenotype to the anti-tumor M1 phenotype while boosting T cell-mediated cytotoxicity and remodeling the immunosuppressive tumor microenvironment. Overall, this strategy presents a promising approach for the targeted treatment of ESCC.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55910–55929"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interfacial Cofactor Recycling Electroenzymatic Platform for Endergonic CO2 Reduction 界面辅因子回收电酶平台的吸氧CO2还原

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-12 DOI: 10.1021/acsami.6c12368

J. Shanthi Sravan, Hyeryeong Lee, Yuna Bang, Celine Imanuel Hermanto, In Seop Chang

引用次数: 0