ACS Applied Materials & Interfaces最新文献

{"title":"Efficient Hydroxymethanesulfonate Electrosynthesis from CO2 and Sulfite over CuPd1 Single-Atom Alloys","authors":"Tingting Wu,&nbsp;Jiang Wang,&nbsp;Fengyu Zhang,&nbsp;Ruixuan Yang,&nbsp;Ye Tian,&nbsp;Ke Chu","doi":"10.1021/acsami.6c19144","DOIUrl":"10.1021/acsami.6c19144","url":null,"abstract":"<p>Electrochemical C–S coupling of CO₂ and sulfite (SO₃^2–) offers a sustainable alternative for hydroxymethanesulfonate (HMS) synthesis, yet its electrocatalytic selectivity remains far from satisfactory. Here, CuPd₁ single-atom alloys (CuPd₁-SAA) are developed as a highly efficient catalyst for HMS electrosynthesis, delivering an exceptional Faradaic efficiency of 56.8% and an HMS yield rate of 301.5 mmol h^–1 g^–1 in an MEA electrolyzer, together with outstanding electrolysis stability for over 200 h of electrolysis. Mechanistic investigations reveal the critical Cu-Pd₁ synergy in driving CO₂ reduction to *CHOH and C–S coupling of *CHOH with *SO₃ for selective HMS generation.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"60885–60891"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149281754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Performance Planar Ni/Si Photothermoelectric Photodetectors Enabled by MnO2 Nanosheets","authors":"Nasir Ali,&nbsp;Wanqing Wu,&nbsp;Di Wu,&nbsp;Huiyu Yuan","doi":"10.1021/acsami.6c13009","DOIUrl":"10.1021/acsami.6c13009","url":null,"abstract":"<p>Photodetectors are the key component of modern communication systems, surveillance applications, robotics, and scientific research. The photothermoelectric effect offers opportunity to fabricate broadband and self-driven photodetectors utilizing thermally energized charge carriers. Unfortunately, photothermoelectric photodetectors are facing the challenge of large dark current, leading to low detectivity, linear dynamic range, and on–off ratio. Herein, we design a planar Ni/n-Si device structure with the help of a monolayer of MnO₂ nanosheets for contact engineering. The demonstrated device shows a broadband detection range from 200 nm to MIR with an external quantum efficiency of 263.6%, a photoresponsivity of 455.1 mA W^–1, a detectivity of ∼7.25 × 10¹² Jones, and an on–off ratio of ∼10³ at 0 V. Additionally, the device shows an unprecedented bias-assisted photoresponsivity and external quantum efficiency of 21.56 A W^–1 and 13,363%, respectively, with 200 nm illumination at –10 V. The nanosheet-based contact engineering provides a powerful strategy to fabricate self-powered photodetectors with high photoresponsivity, external quantum efficiency, and broadband detection from the solar blind region to the MIR spectrum.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"60948–60959"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149303322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial Polymerization Using Acyl Chloride-Functionalized Porphyrin Comonomers toward Robust PA-66 with Type I/II Dual Photodynamic Antibacterial Durability","authors":"Meiyu Zhen,&nbsp;Ziyi Lu,&nbsp;Xingyu Wu,&nbsp;Chang Wang,&nbsp;Yujian Li,&nbsp;Xiaoqing Xiong","doi":"10.1021/acsami.6c21904","DOIUrl":"10.1021/acsami.6c21904","url":null,"abstract":"<p>The growing threat of bacterial contamination and antibiotic resistance urgently requires functional antibacterial textiles. Photodynamic antibacterial approaches relying on reactive oxygen species (ROS) provide a promising alternative to achieve safe and long-term antimicrobial protection. Herein, a fabrication strategy was developed to construct intrinsically photodynamic antibacterial polyamide 66 (PA-66) yarns via interfacial polymerization. Acyl chloride-modified porphyrin (TCPP-Cl₄), acting as a ternary monomer, was covalently grafted onto PA-66 molecular chains via interfacial polymerization. Subsequent drawing, spinning, and twisting yielded functional <strong>TCPP-Cl</strong>_{<strong>4</strong>}<strong>-PA-66</strong> yarns that preserved the favorable mechanical performance and thermal stability of PA-66. Physically blended <strong>TCPP/PA-66</strong> yarns were also prepared as reference samples. Compared with <strong>TCPP/PA-66</strong> yarns, the covalent anchoring process effectively reduced photosensitizer leaching and improved ROS generation capacity. As a result, <strong>TCPP-Cl</strong>_{<strong>4</strong>}<strong>-PA-66</strong> yarns achieved antibacterial efficiencies of 97.4 ± 1.3% against <em>Staphylococcus aureus</em> (<em>S. aureus</em>) and 94.0 ± 2.8% against <em>Escherichia coli</em> (<em>E. coli</em>). Furthermore, this covalent immobilization also endowed the yarns with favorable washing resistance, maintaining stable photodynamic antibacterial activity against both strains after multiple washing cycles. Interwoven fabrics fabricated from <strong>TCPP/PA-66</strong>, <strong>TCPP-Cl</strong>_{<strong>4</strong>}<strong>-PA-66</strong>, and cotton yarns also exhibited desirable photodynamic antibacterial performance. This work provides a facile strategy for constructing photodynamic antibacterial textile materials with good stability.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"61440–61456"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149304773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensively Unveiling the Dual Antifungal and Antibacterial Activity of Ultra-small Pt Nanoclusters through Membrane Impairment Induced by Oxidative Stress","authors":"Xin Huang,&nbsp;Mengjun Zhang,&nbsp;Wanting Yu,&nbsp;Jingwen Ma,&nbsp;Chuang Ma,&nbsp;Yazhong Qu,&nbsp;Xu Li,&nbsp;Shaobo Wang,&nbsp;Haodi Yue,&nbsp;Jialin Wang","doi":"10.1021/acsami.6c20484","DOIUrl":"10.1021/acsami.6c20484","url":null,"abstract":"<p>Microorganisms, including bacteria, fungi, and viruses, can invade the human body, disrupt normal physiological functions, and trigger a variety of infectious diseases, currently posing a significant global health issue. Silver (Ag), gold (Au), and titanium dioxide (TiO₂) nanomaterials have already demonstrated exciting antimicrobial properties and promising therapeutic applications. However, the antibacterial performance of Pt nanomaterials, especially nanoclusters (NCs, &lt;2 nm), has rarely been investigated. In this study, Pt NCs with an ultra-small size of 1.5 ± 0.5 nm were produced by a reduction method, and their structure presents a composite of fine atomic clusters. A series of bacteriostatic experiments proved that the sterilizing rates of Gram-negative bacteria <em>Escherichia coli</em> (<em>E. coli</em>) and Gram-positive bacteria <em>Staphylococcus aureus</em> (<em>S. aureus</em>) are 98.02 and 99.99%, respectively. In addition, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Pt NCs against <em><em>Fusarium solani</em></em> (<em>F. solani</em>) were determined to be as low as 0.8 and 1.7 μg/mL, and these Pt NCs exhibited fungicidal activity. The antibacterial and antifungal mechanisms were elucidated, showing that the oxidative stress generated via the excessive reactive oxygen species (ROS) induced by Pt NCs triggers the chain reaction of lipid peroxidation (LPO), consequently causing the structural degradation and functional impairment of membranes, ultimately resulting in the cytoplasmic contents leaking and bacterial/fungal death. Astonishingly, the wound healing rate for methicillin-resistant <em>S. aureus</em> (MRSA) infections was 98.90% at 10 days post treatment by Pt NCs, indicating significantly higher efficacy than that of the conventional broad-spectrum antibacterial fluoroquinolone drug ofloxacin. Furthermore, the antimicrobial gauze fabricated using these Pt NCs exhibited at least 99.75% inhibition of both <em>E. coli</em> and <em>S. aureus</em> within 24 h, suggesting their promising application prospects as a novel and safer antibacterial and antifungal agent.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"60649–60665"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149305126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear Curved Metasurfaces for Enhanced Thyroid Magnetic Resonance Imaging","authors":"Zhiang Wang,&nbsp;Zhonghai Chi,&nbsp;Xinxin Li,&nbsp;Yakui Wang,&nbsp;Zhuozhao Zheng,&nbsp;Qian Zhao","doi":"10.1021/acsami.6c16968","DOIUrl":"10.1021/acsami.6c16968","url":null,"abstract":"<p>Metasurfaces offer a promising approach to enhance the signal-to-noise ratio (SNR) in magnetic resonance imaging (MRI). Thyroid MRI suffers from insufficient SNR due to the anatomical irregularity of the neck and poor coil-to-tissue proximity, which fails to meet the demands of preoperative tumor diagnosis. This work introduces a nonlinear, curved metasurface tailored to address these limitations through a nonlinear mode control scheme based on up-frequency tuning. Unlike the previously reported down-frequency tuning scheme, here the metasurface's resonant frequency is selectively shifted to a frequency above the Larmor frequency during RF transmit via an integrated diode-inductor circuit, thereby minimizing <span><em>B</em><span>⁺₁</span></span> perturbation and specific absorption rate increase. Concurrently, its conformal curved geometry focuses the enhanced field on the concave side, optimizing penetration for superficial targets. This adaptive mechanism minimally perturbs the transmit field while keeping the device fully active during signal reception. Experiments demonstrate that this thyroid imaging curved metasurface (TCM) provides an SNR enhancement by a factor of over six in the target thyroid region and an effective penetration depth of approximately 60 mm over the whole range of up-frequency inductances examined (27–100 nH), for which the two-fold gain is maintained to about 70 mm, validating its potential as a practical, wireless adjunct for high-quality thyroid MRI.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"60608–60619"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149305127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible Artificial Neurons Based on NbOx for Robust Tactile Perception in a Wide Temperature Range","authors":"Haolin Wang,&nbsp;Jiangwen Qiu,&nbsp;Weisheng Wang,&nbsp;Zhenyi Ni,&nbsp;Dongke Li,&nbsp;Liqiang Zhu,&nbsp;Yue Wang,&nbsp;Deren Yang,&nbsp;Xiaodong Pi","doi":"10.1021/acsami.6c16499","DOIUrl":"10.1021/acsami.6c16499","url":null,"abstract":"<p>Neuromorphic tactile sensing that emulates biological touch enables artificial systems to work with high efficiency and low energy consumption. As tactile-sensing scenarios may involve curved surfaces and different temperatures, artificial spiking afferent neurons require both flexibility and temperature robustness at the front end of artificial systems. Here, we report flexible artificial spiking neurons based on niobium oxide (NbO_<em>x</em>) threshold-switching (TS) memristors prepared on polyimide (PI) substrates. Temperature-dependent transport analysis indicates that their temperature robustness is associated with a bulk switching pathway in the NbO_<em>x</em> film. By integrating an oscillation circuit, the NbO_<em>x</em> spiking afferent neurons convert analog inputs into frequency-modulated voltage spikes and retain oscillatory capability from –80 to 80 °C at a bending radius of 5 mm. Moreover, pressure sensors are coupled with the NbO_<em>x</em> neurons to form mechanoreceptors that encode pressure as oscillation frequency. In the numerical tactile-recognition workflow, a convolutional neural network (CNN) classifies spatial frequency maps generated from the fitted pressure-to-frequency relations, achieving accuracies of 97.5% under the baseline condition and 93.2% at 80 °C at a bending radius of 5 mm. This work demonstrates that flexible NbO_<em>x</em> neurons can serve as compact event-driven front ends for wide-temperature robotic tactile sensing.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"60990–61003"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149305128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coral-Inspired Thermodynamically Stable-Phase Core-Shell Strategy Enables α-Al2O3@SiO2 Aerogels with Thermal Stability up to 1500 °C and Superhydrophobicity","authors":"Zhendong Jiang,&nbsp;Yonggang Jiang,&nbsp;Mengyao Zhao,&nbsp;Junzong Feng,&nbsp;Yijie Hu,&nbsp;Jian Feng","doi":"10.1021/acsami.6c16249","DOIUrl":"10.1021/acsami.6c16249","url":null,"abstract":"<p>Alumina aerogels have attracted great interest for extreme thermal insulation. However, traditional alumina aerogels inevitably undergo severe structural degradation above 1000 °C due to the metastable-to-α phase transformation, which fundamentally limits their ultrahigh-temperature applications. In nature, red coral constructs its robust porous skeleton directly from calcite, the thermodynamically stable polymorph of CaCO₃, thereby achieving exceptional long-term structural durability. Inspired by this “thermodynamically stable-phase construction” wisdom, we herein propose a thermodynamically stable-phase core-shell (TSC) strategy that employs thermodynamically stable α-Al₂O₃ nanoparticles as building blocks. The in situ sol-gel growth of a methyl-containing SiO₂ shell on the nanoparticle surfaces directly yields three-dimensional continuous α-Al₂O₃@SiO₂ core-shell aerogels (SAAs). The resulting SAAs exhibit outstanding ultrahigh-temperature thermal stability, retaining a non-collapsed porous skeleton with a high specific surface area retention of 23.6% after calcination at 1500 °C in air for 2 h. They also display excellent superhydrophobicity, with a water contact angle as high as 163.0° and a rolling angle as low as 2.9°. Furthermore, the SAAs deliver remarkable thermal insulation performance, exhibiting a room-temperature thermal conductivity of only 0.0394 W·m⁻¹·K⁻¹. When exposed to a 1300 °C butane torch flame for 120 s, a merely 4-mm-thick SAAs plate registers a cold-side temperature rise of only 141 °C. Molecular dynamics simulations reveal that the SiO₂ shell acts as an efficient physical and diffusion barrier, effectively suppressing sintering neck formation and atomic diffusion between particles, thereby preserving the nanostructure at extreme temperatures. This work not only provides a coral-inspired stable-phase construction pathway toward lightweight ceramic aerogels for extreme environments but also establishes a general approach for constructing sintering-resistant nanostructures based on thermodynamically stable-phase nanoparticles via core-shell engineering.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"61122–61132"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149250812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facet- and Size-Related Electrical Conductivity and Piezocatalytic Behaviors of Co3O4 Crystals from Lattice Deviation","authors":"Hong-Wei Sun,&nbsp;Satyaranjan Jena,&nbsp;Chih-Hsueh Li,&nbsp;Michael H. Huang","doi":"10.1021/acsami.6c14773","DOIUrl":"10.1021/acsami.6c14773","url":null,"abstract":"<p>Size-tunable Co₃O₄ cubes (136 and 276 nm), cuboctahedra (168 and 240 nm), and octahedra (180 and 258 nm) have been hydrothermally synthesized. Synchrotron X-ray diffraction (XRD) analysis suggests best fitting of peaks into bulk and surface layer lattice components for all the samples. Fast Fourier transform (FFT) processing of high-resolution transmission electron microscopy (HR-TEM) images shows a regular array of lattice points in the interior bulk but significant spot distortion in the surface layer. The surface lattice deviation patterns are distinct for different particle morphologies. Their band gaps can vary with particle size and shape. For the smaller crystals, an octahedron is electrically highly conductive, but a cube is nearly insulating from representative single-particle measurements. Cuboctahedra and octahedra also show higher piezoelectric responses than cubes do. Regardless of the particle shape, the smaller crystals are clearly more piezocatalytically effective at dye degradation than the larger ones. Active species generated in piezocatalysis have been identified. Lattice deviations from crystal shape control is a good way to enhance material properties.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"61103–61110"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149269120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-Active Hydrogen Coverage Engineering Enables Selective Electrochemical Hydrogenation of Nitrobenzene over a CoFe Catalyst","authors":"Jingzhe Tao,&nbsp;Weijian Wang,&nbsp;Zihao Diao,&nbsp;Haoyun Dou,&nbsp;Zhengyu Wang,&nbsp;Xiaowei Shi,&nbsp;Hong-En Wang,&nbsp;Lingxia Zheng","doi":"10.1021/acsami.6c15490","DOIUrl":"10.1021/acsami.6c15490","url":null,"abstract":"<p>Electrocatalytic hydrogenation of nitroarenes to aromatic amines is significant, but selectivity control remains challenging. Herein, a series of CoFe non-precious catalysts are prepared on carbon cloth via a facile constant-current deposition method. The optimal CoFe catalyst features a 3D honeycomb-like porous structure with a high electrochemically active surface area and enhanced mass transfer, delivering the highest cathodic current density and the most positive onset potential. At –1.2 V vs Hg/HgO, the nitrobenzene (NB) conversion approaches 100%, with the aniline (AN) yield and selectivity both exceeding 95%, demonstrating outstanding NB electroreduction (NBER) performance. In-situ Fourier-transform infrared spectroscopy (FTIR) confirms the reaction pathway NB → NSB → PHA → AN. Theoretical calculations reveal that CoFe optimizes the electronic structure to modulate the surface coverage of active hydrogen (*H) from water dissociation, thereby promoting the hydrogenation reaction while efficiently suppressing the competing hydrogen evolution reaction. Coupling this cathode with 5-hydroxymethylfurfural (HMF) oxidation to produce 2,5-furandicarboxylic acid (FDCA) gives a higher energy utilization efficiency and economic returns than the conventional system that coupled with the oxygen evolution reaction. This work demonstrates a promising strategy for upgrading both nitroaromatic and biomass-derived substrates via green electrosynthesis, offering a viable route toward the energy-efficient and economically attractive co-production of fine chemicals.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"60741–60752"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149269125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric Janus Patch Integrating Antifouling and Wet-Adhesive Functions for Infected Wound Repair","authors":"Zuqin Dong,&nbsp;Xiaoju Fan,&nbsp;Lei Tong,&nbsp;Jingyi Liu,&nbsp;Jie Liang,&nbsp;Yujiang Fan","doi":"10.1021/acsami.6c16106","DOIUrl":"10.1021/acsami.6c16106","url":null,"abstract":"<p>The wet, dynamic, and bacteria-contaminated microenvironment of infected wounds creates conflicting demands for stable wound-facing adhesion and outward antifouling protection. To address these demands, we developed an asymmetric Janus hydrogel-film patch (JP-TA/Fe) with a coordination-stabilized bilayer interface. The patch consisted of a dense nonadhesive layer containing silk fibroin/tannic acid (SF/TA) and an adhesive hydrogel layer containing polyacrylic acid/recombinant collagen/tannic acid (PAA/rhCol/TA). TA-Fe³⁺ chelation was introduced at the bilayer interface through a facile process to strengthen interlayer bonding and maintain bilayer structural integrity during hydration and mechanical deformation. The outward-facing SF/TA layer provided mechanical support and an antifouling barrier, whereas the wound-facing hydrogel layer exhibited favorable fluid-uptake capacity and maintained stable tissue adhesion. Benefiting from this asymmetric design, the patch exhibited robust wet-tissue adhesion, pH-responsive TA release, asymmetric antifouling and adhesive properties, antibacterial activity, biofilm-disrupting performance, and efficient reactive oxygen species (ROS)-scavenging capacity. In a rat full-thickness skin incision model and a <em>Staphylococcus aureus</em>-infected full-thickness skin defect model, JP-TA/Fe promoted stable wound closure, reduced bacterial burden, and accelerated collagen remodeling and epidermal regeneration. This study presents a structurally stable Janus wound patch with spatially differentiated functions, providing a multifunctional material platform for infected wound repair.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 44","pages":"60531–60548"},"PeriodicalIF":7.8,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149281745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}