ACS Applied Materials & Interfaces最新文献_第4页

Zn Lattice Site-Dependent Emission of Sb3+-Doped (ETBT)2ZnBr4 Organic-Inorganic Halide Perovskite for Tunable Lighting and Night-Vision Applications. Sb3+掺杂（ETBT）2ZnBr4有机-无机卤化物钙钛矿在可调照明和夜视应用中的Zn点阵位依赖发射

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2025-07-02 DOI: 10.1021/acsami.5c07463

Hu Wang,Yuexiao Pan,Hongzhou Lian,Jun Lin,Wenxia Zhang

{"title":"Zn Lattice Site-Dependent Emission of Sb3+-Doped (ETBT)2ZnBr4 Organic-Inorganic Halide Perovskite for Tunable Lighting and Night-Vision Applications.","authors":"Hu Wang,Yuexiao Pan,Hongzhou Lian,Jun Lin,Wenxia Zhang","doi":"10.1021/acsami.5c07463","DOIUrl":"https://doi.org/10.1021/acsami.5c07463","url":null,"abstract":"In the realm of lighting and display technologies, the pursuit of single-matrix multifunctional light sources that are both environmentally friendly and highly tunable is of the utmost necessity. We obtained an organic-inorganic halide perovskite crystal (OIHPCs) (ETBT)2ZnBr4, which possesses two distinct crystallographic sites for Zn, namely Zn1 and Zn2. By doping with Sb3+, a broad emission with two prominent emission peaks at 530 and 670 nm has been achieved, which originate from the triplet emission of Sb3+ occupied at different luminescent centers. By altering the excitation wavelength, the luminescence color of the material can be tuned from green to yellow and then to red. Density functional theory (DFT) calculations confirmed the difference of band gap after Sb3+ replacing Zn1 and Zn2, corresponding to the green and red emissions. Under 365 nm excitation, the emission spectrum of (ETBT)2ZnBr4:Sb3+ extends into the near-infrared region, making it suitable for applications such as night vision. This study provides a new approach to achieving single-host multifunctional light sources using nontoxic perovskite materials, offering potential applications in optoelectronic devices and bioimaging.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"19 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-Activated GelMA Hydrogel Loaded with MSC-EVs Promotes Functional Regeneration of Skin Vasculature, Nerves, and Appendages. 装载msc - ev的超声激活凝胶水凝胶促进皮肤血管系统、神经和附属物的功能再生。

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2025-07-02 DOI: 10.1021/acsami.5c07357

Bingyang Yu,Chao Zhang,Dongzhen Zhu,Yanlin Su,Xu Guo,Feng Tian,Jianjun Li,Zhao Li,Wei Song,Yi Kong,Jinpeng Du,Mengde Zhang,Yuyan Huang,Liting Liang,Qinghua Liu,Yaxin Tan,Yue Kong,Yuzhen Wang,Linhao Hou,Sha Huang

{"title":"Ultrasound-Activated GelMA Hydrogel Loaded with MSC-EVs Promotes Functional Regeneration of Skin Vasculature, Nerves, and Appendages.","authors":"Bingyang Yu,Chao Zhang,Dongzhen Zhu,Yanlin Su,Xu Guo,Feng Tian,Jianjun Li,Zhao Li,Wei Song,Yi Kong,Jinpeng Du,Mengde Zhang,Yuyan Huang,Liting Liang,Qinghua Liu,Yaxin Tan,Yue Kong,Yuzhen Wang,Linhao Hou,Sha Huang","doi":"10.1021/acsami.5c07357","DOIUrl":"https://doi.org/10.1021/acsami.5c07357","url":null,"abstract":"Severe skin injuries often lead to dysfunctional healing marked by fibrosis and loss of vascular, neural, and appendage structures. While mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) offer regenerative potential, their therapeutic efficacy is limited by poor delivery efficiency. Here, we present a bioengineered strategy combining ultrasound stimulation with a gelatin methacryloyl (GelMA) hydrogel-EV delivery platform to address these challenges. Ultrasound serves as a mechanobiological primer, enhancing MSC-EVs internalization via calcium-dependent cytoskeletal remodeling, thereby amplifying pro-regenerative pathways such as angiogenesis (such as VEGF), matrix modulation (such as TGF-β/Smad), and neural repair (such as NGF). In vitro, ultrasound (420 kHz, 5 V) synergized with MSC-EVs (60 μg/mL) significantly boosted fibroblast viability, migration, and secretory functions. In a murine full-thickness wound model, the ultrasound-activated GelMA-EV system accelerated re-epithelialization (90% closure by Day 14), induced robust neovascularization and neurogenesis, and facilitated unprecedented hair follicle regeneration. Mechanistic studies revealed ultrasound-driven calcium in-flow and actin depolymerization as key mediators of enhanced MSC-EVs uptake. This synergistic integration of physical and biochemical cues establishes a transformative paradigm for functional skin regeneration, bridging a critical gap in regenerative therapeutics.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"10 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Nanocarrier Landscape─Evaluating Key Drug Delivery Vehicles and Their Capabilities: A Translational Perspective. 纳米载体景观─评估关键药物递送载体及其能力：翻译视角。

IF 8.3 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2025-07-02 Epub Date: 2025-06-17 DOI: 10.1021/acsami.5c07366

Fahd Khalid-Salako, Soodeh Salimi Khaligh, Farzaneh Fathi, Osman C Demirci, Nazlı Öncer, Hasan Kurt, Meral Yüce

{"title":"The Nanocarrier Landscape─Evaluating Key Drug Delivery Vehicles and Their Capabilities: A Translational Perspective.","authors":"Fahd Khalid-Salako, Soodeh Salimi Khaligh, Farzaneh Fathi, Osman C Demirci, Nazlı Öncer, Hasan Kurt, Meral Yüce","doi":"10.1021/acsami.5c07366","DOIUrl":"10.1021/acsami.5c07366","url":null,"abstract":"The field of nanomedicine is currently in a revolutionary phase, propelled by the significant potential of nanoparticles, which offer several advantages over traditional drug delivery systems. The purpose of this paper is to aggregate contemporary knowledge of nanoparticles developed and applied in drug delivery across major disease classes. Accordingly, we offer, through a thorough search of the literature, a comprehensive overview of the prevalent nanoparticles used in drug delivery systems, covering polymeric, lipid-based, inorganic, and carbon-based nanoparticles, and discuss their advantages and limitations. This work primarily focuses on studies published in the last 5 years, aiming to provide an up-to-date assessment of the critical nanoparticles in drug delivery. Narratively, we synthesize a comprehensive overview of the state-of-the-art in nanocarrier technology, providing in-depth insights into the key nanoparticle types presented in the contemporary literature, their fundamental benefits, potential clinical applications, and limitations impeding their development and adoption. We note that there are gaps and opportunities for concerted efforts focused on developing biocompatible and biodegradable nanoparticles, establishing scalable and cost-effective manufacturing processes, and addressing regulatory challenges associated with nanoparticle-based drug delivery systems. These challenges persist despite the immense translational success of nanoparticle-based drug delivery systems and necessitate continued interdisciplinary research and cross-industry collaboration among scientists, clinicians, and regulatory bodies.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":"37383-37403"},"PeriodicalIF":8.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Arginine-Inspired Nanocomposite Enhances Tumor Oxygenation for Optimized Photodynamic Therapy. 精氨酸激发的纳米复合材料增强肿瘤氧合以优化光动力治疗。

IF 8.3 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2025-07-02 Epub Date: 2025-06-19 DOI: 10.1021/acsami.5c07882

Weiqing Yue, Zhijie Fang, Ting Yu, Wanyi Wang, Han Yu, Zizi Wu, Xi Li, Ganger Yangzom, Xiaomei Lu, Qiong Wu, Jie Li

{"title":"An Arginine-Inspired Nanocomposite Enhances Tumor Oxygenation for Optimized Photodynamic Therapy.","authors":"Weiqing Yue, Zhijie Fang, Ting Yu, Wanyi Wang, Han Yu, Zizi Wu, Xi Li, Ganger Yangzom, Xiaomei Lu, Qiong Wu, Jie Li","doi":"10.1021/acsami.5c07882","DOIUrl":"10.1021/acsami.5c07882","url":null,"abstract":"The hypoxic, or low-oxygenation, state within the tumor microenvironment (TME) is highly detrimental to certain oxygen-dependent therapeutic approaches, particularly Type II photodynamic therapy (PDT). Current methods to enhance tumor oxygenation include utilizing perfluorocarbon-based oxygen-carrying techniques and inhibiting cellular respiration to improve the oxygen supply. However, these approaches generally suffer from a low oxygenation efficiency. To address this, we proposed an arginine cluster-mimicking nanocomposite (CP-PArg-PFC) for oxygen delivery, aimed at elevating tumor oxygenation levels and thereby optimizing the efficacy of photosensitized therapy. This nanomaterial integrates an arginine-inspired photosensitizer (CP-PArg) with an amphiphilic perfluorocarbon derivative (PEG-PFC). The arginine cluster structure leverages the high metabolic activity of tumor cells to achieve efficient, targeted accumulation in tumors. While it generates photodynamic effects, it also possesses NIR-II fluorescence imaging capabilities, making it an excellent theranostic agent. Furthermore, polymerized perfluorocarbon enables efficient and stable oxygen transport, while nitric oxide produced via enzymatic arginine degradation suppresses tumor cell respiration. This dual-mode synergistic mechanism effectively enhances tumor oxygenation and alleviates hypoxia in the TME. By employing this design strategy of oxygen-carrying nanomaterials, we successfully achieved significant improvement in tumor tissue oxygenation and performed optimized PDT on breast tumors.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":"37735-37746"},"PeriodicalIF":8.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turning Down the Inhibition Effect of Silica Gels in Protein Crystallization. 降低硅胶对蛋白质结晶的抑制作用。

IF 8.3 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2025-07-02 Epub Date: 2025-06-19 DOI: 10.1021/acsami.5c07593

Lorena Pasero, Roberto Pisano, José A Gavira, Fiora Artusio

{"title":"Turning Down the Inhibition Effect of Silica Gels in Protein Crystallization.","authors":"Lorena Pasero, Roberto Pisano, José A Gavira, Fiora Artusio","doi":"10.1021/acsami.5c07593","DOIUrl":"10.1021/acsami.5c07593","url":null,"abstract":"Silica gels act as nucleation inhibitors and have been used to grow large protein crystals in convection-free environments. However, a large amount of protein is required to overcome the inhibition effect, and chances of successful crystallization are limited, hampering its potential benefits. In the present study, we propose the substitution of silanol groups with methylated additives to increase the hydrophobicity of the gel network, decrease the interaction between proteins and gel fibers, and tune the inhibition effect of silica gels. We observed an increased hen egg white lysozyme (HEWL) nucleation density in gels bearing a higher number of methyl groups. We used the counter-diffusion crystallization technique for our proof of concept since it does not require a fine adjustment of the supersaturation. We then moved to batch crystallization for maintaining constant supersaturation conditions in order to have comparative results. We were able to grow HEWL crystals with tailored sizes depending on the amount of hydrophobic moieties' substitution. The modification of the gel reduced the amount of protein required to induce nucleation. This effect was attributed to the decreased adsorption of protein macromolecules on gel fibers carrying hydrophobic groups. This simple chemical modification approach may expand the use of silica gels, traditionally seen as protein nucleation inhibitors, to produce new crystalline composite materials.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":"37698-37706"},"PeriodicalIF":8.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of Metal-N₂O₂ Sites on Poly(ionic liquid) for Highly Efficient Electrocatalytic CO₂ Reduction. 高效电催化CO2还原聚离子液体金属- n2o2位的构建

IF 8.3 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2025-07-02 Epub Date: 2025-06-23 DOI: 10.1021/acsami.5c06177

Shu-Fan Lv, Xiao-Qiang Li, Yi-Ran Du, Rui Wang, Zhao-Rong Yan, Jia-Ni Li, Rui Zhang, Bao-Hua Xu

{"title":"Construction of Metal-N2O2 Sites on Poly(ionic liquid) for Highly Efficient Electrocatalytic CO2 Reduction.","authors":"Shu-Fan Lv, Xiao-Qiang Li, Yi-Ran Du, Rui Wang, Zhao-Rong Yan, Jia-Ni Li, Rui Zhang, Bao-Hua Xu","doi":"10.1021/acsami.5c06177","DOIUrl":"10.1021/acsami.5c06177","url":null,"abstract":"In this study, atomically dispersed metal catalysts of Salen-PIL(M) (M = Zn and Cu) for electrochemical CO2-to-C1 conversion were fabricated by polymerization of a vinyl-decorated ionic liquid (IL) monomer bearing a Salen-M moiety with para-diethylbenzene. The characterization results indicated that the Salen-Zn/Cu complex was atomically dispersed in the PIL skeleton. They differed significantly in the electron transfer speed to CO2, CO affinity, and H2O activation, which influenced both the activity and selectivity toward CO or CH4. Besides, the formation of CO2•-* and H2O activation were related to the tolerance of the pH range. Meanwhile, the adjustment of the interfacial H2O content by introducing a hydrophobic IL benefited the competitive CO2RR versus HER on Salen-PIL(Zn/Cu) catalysts. As a result, Salen-PIL(Zn) provided a CO faradaic efficiency (FECO) of 90.1% with a partial current density (jCO) of 90.1 mA cm-2 at -0.85 V, while a FECH4 of 54.5% with jCH4 of 272.5 mA cm-2 at -1.60 V was obtained on Salen-PIL(Cu).","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":"37927-37935"},"PeriodicalIF":8.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 8.3 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2025-07-02

Weiqing Yue, Zhijie Fang, Ting Yu, Wanyi Wang, Han Yu, Zizi Wu, Xi Li, Ganger Yangzom, Xiaomei Lu*, Qiong Wu* and Jie Li*,