ACS Applied Materials & Interfaces最新文献_第4页

Signal Amplification via Nonlinear Femtosecond Laser Filamentation for Trace Metal Ion Detection Using Metal–Organic Framework–Polymer Adsorbents

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c20725

Xin Hua, Xiaolin Fan, Ying Ye, Xiangyang Wang, Cankun Zhang, Yibin Jiang, Yusheng Zhang, Cheng Wang

引用次数: 0

Amphiphilic Photoluminescent Porous Silicon Nanoparticles as Effective Agents for Ultrasound-Amplified Cancer Therapy

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c15725

Maxim B. Gongalsky, Uliana A. Tsurikova, Andrey A. Kudryavtsev, Nikolay V. Pervushin, Andrey P. Sviridov, Tushar Kumeria, Victoria D. Egoshina, Pyotr A. Tyurin-Kuzmin, Ilia A. Naydov, Kirill A. Gonchar, Gelina S. Kopeina, Valery G. Andreev, Boris Zhivotovsky, Liubov A. Osminkina

{"title":"Amphiphilic Photoluminescent Porous Silicon Nanoparticles as Effective Agents for Ultrasound-Amplified Cancer Therapy","authors":"Maxim B. Gongalsky, Uliana A. Tsurikova, Andrey A. Kudryavtsev, Nikolay V. Pervushin, Andrey P. Sviridov, Tushar Kumeria, Victoria D. Egoshina, Pyotr A. Tyurin-Kuzmin, Ilia A. Naydov, Kirill A. Gonchar, Gelina S. Kopeina, Valery G. Andreev, Boris Zhivotovsky, Liubov A. Osminkina","doi":"10.1021/acsami.4c15725","DOIUrl":"https://doi.org/10.1021/acsami.4c15725","url":null,"abstract":"This study investigates the use of photoluminescent amphiphilic porous silicon nanoparticles (αϕ-pSiNPs) as effective ultrasound (US) amplifiers for cancer sonodynamic theranostics. αϕ-pSiNPs were synthesized via a novel top-down approach involving porous silicon (pSi) films electrochemical etching, borate oxidation, and hydrophobic coating with octadecylsilane (C18), resulting in milling into nanoparticles with hydrophilic exteriors and hydrophobic interiors. These properties promote gas trapping and cavitation nucleation, significantly lowering the US cavitation threshold and resulting in selective destruction of cancer cells in the presence of nanoparticles. Efficient internalization of αϕ-pSiNPs in cell cytoplasm was demonstrated by their intrinsic photoluminescence, activated by partial oxidation of mesoporous silicon films in borate solutions, which resulted in quantum confinement of excitons in 2–5 nm Si quantum dots/wires. Combined with US exposure above the cavitation threshold, αϕ-pSiNPs caused a significant decrease in cell viability through mechanical stretching and microflows generated by oscillating microbubbles. Meanwhile, αϕ-pSiNPs exhibit high biocompatibility up to concentrations of 1 mg/mL without US activation. Their photoluminescent properties facilitate bioimaging, while their US contrast capabilities may enhance both imaging and therapy. The dual functionality of αϕ-pSiNPs supports a theranostic approach, enabling simultaneous diagnostics and treatment with a single agent. This study underscores the potential of αϕ-pSiNPs in sonodynamic therapy and bioimaging, offering a promising strategy for effective and safe anticancer therapy.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"24 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capture and Diffusion of Hydrogen in Tantalum and Copper with Vacancy Defects: A First-Principles Study

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c13331

Xiaoqing Liu, Pingze Zhang, Mengling Zhan, Bo Dang, Kai Yang, Peide Han

{"title":"Capture and Diffusion of Hydrogen in Tantalum and Copper with Vacancy Defects: A First-Principles Study","authors":"Xiaoqing Liu, Pingze Zhang, Mengling Zhan, Bo Dang, Kai Yang, Peide Han","doi":"10.1021/acsami.4c13331","DOIUrl":"https://doi.org/10.1021/acsami.4c13331","url":null,"abstract":"Oxygen-free copper is utilized in nuclear processing heaters; however, it exhibits poor resistance to hydrogen radiation corrosion. A tantalum–copper diffusion layer with high vacancy concentration was prepared on the copper surface. This layer demonstrates superior hydrogen trapping and diffusion resistance compared to pure tantalum, though the underlying mechanism remains unclear. First-principles DFT methods were employed to investigate the absorption of hydrogen atoms by tantalum and copper vacancies, forming vacancy-hydrogen complexes, and their diffusion characteristics. These were compared with interstitial configurations. The ground state formation energy is lowest when a tantalum vacancy captures six hydrogen atoms. It can accommodate up to 12 hydrogen atoms while maintaining a higher energy than the interstitial configuration, forming a spherical structure with special symmetry. For copper vacancies, the formation energy remains higher than the interstitial configuration when capturing up to six hydrogen atoms. The high-vacancy diffusion layer exhibits a strong hydrogen trapping capacity. Posthydrogen capture, the overall migration energy for both tantalum and copper vacancies exceeds 2.5 eV. The energy barrier for individual hydrogen atom diffusion outward is higher than in interstitial cases when capturing up to six hydrogen atoms. Vacancies capturing hydrogen atoms play a role in maintaining the stability of hydrogen in its ground state.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"24 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Phase Change Films with High Mechanical Strength, Thermally Induced Switchable Adhesion, and Shape Recoverability for Infrared Stealth

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c18276

Guangyu Zhu, Wenjing Chen, Xiaowu Hu, Wenxing Luo, Yan Ma, Jue Wang, Sifan Tan, Yifan Huang, Jinghui Fan, Xiongxin Jiang, Qinglin Li

{"title":"Multifunctional Phase Change Films with High Mechanical Strength, Thermally Induced Switchable Adhesion, and Shape Recoverability for Infrared Stealth","authors":"Guangyu Zhu, Wenjing Chen, Xiaowu Hu, Wenxing Luo, Yan Ma, Jue Wang, Sifan Tan, Yifan Huang, Jinghui Fan, Xiongxin Jiang, Qinglin Li","doi":"10.1021/acsami.4c18276","DOIUrl":"https://doi.org/10.1021/acsami.4c18276","url":null,"abstract":"The application of organic solid–liquid phase change materials (PCMs) is limited for the leakage problem after phase change and high rigidity. In this work, a novel flexible solid–solid PCM (DXPCM) was synthesized using a block copolymerization process with polyethylene glycol (PEG) as the energy storage segment. The phase transition temperature (from 36.2 to 49.4 °C) and enthalpy (from 83.27 to 123.35 J/g) of DXPCM could be changed through adjusting the molecular weight of PEG. The introduction of hard chain segments endowed DXPCM with excellent flexibility, foldability, and mechanical properties at room temperature. The large number of internal hydrogen bonds and π–π stacking provided DXPCM with interesting thermally induced switchable adhesion and recyclability. The storage and release of elastic potential energy ensured that DXPCM could recover its original shape after being deformed by external forces. It is worth mentioning that DXPCM exhibits excellent infrared stealth capability as it can absorb and release latent heat for a long period of time. In conclusion, this work developed a novel solid–solid phase change film with high mechanical strength, thermally induced switchable adhesion, and shape recovery capability, which has great potential for application in infrared stealth.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"50 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WS2/Graphene/MoS2 Sandwich van der Waals Heterojunction for Fast-Response Photodetectors

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c13818

Yongzhi Zhang, Xunjun He

{"title":"WS2/Graphene/MoS2 Sandwich van der Waals Heterojunction for Fast-Response Photodetectors","authors":"Yongzhi Zhang, Xunjun He","doi":"10.1021/acsami.4c13818","DOIUrl":"https://doi.org/10.1021/acsami.4c13818","url":null,"abstract":"Fast-response photodetectors have attracted considerable attention in the application of high-speed communication, real-time monitoring, and optical imaging systems. However, most reported photodetectors suffer from limitations of the inherent properties of materials, low carrier transport efficiency, and unmatched interfaces, which lead to a low response speed. Here, we report a WS2/graphene/MoS2 vertical van der Waals heterojunction fabricated by mechanical exfoliation and dry transfer methods for fast response. To improve the response speed of the previously reported WS2/MoS2 heterojunction with excellent photoelectric performances, the embedded graphene is employed to optimize the interface defects and improve the carrier transport efficiency due to its high mobility and smooth and flat surface. Under the illuminations of a 405 nm laser and a bias voltage of 0.5 V, our device can realize rise and fall times of 44 and 52 μs, respectively. For a bias voltage of 2.5 V, moreover, the device can also show outstanding performances including a high responsivity of 220 A/W, a considerable detectivity of 1.2 × 1013 Jones, a large external quantum efficiency of 6.7 × 104 %, and a low dark current of 1.05 × 10–13 A. Additionally, the device enables high-speed transmission with a low bit error rate in a closed-loop optical communication system. Therefore, the proposed scheme can provide an idea for the design of photodetectors with fast response and high performance.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"13 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Enzymatic Glycan Engineering of Extracellular Vesicles Using Nanomaterial-Interfaced Microfluidics

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c20294

Xin Zhou, Mohit Jaiswal, Jingzhu Shi, Jiatong Guo, Sayan Kundu, Zhongwu Guo, Yong Zeng

{"title":"Efficient Enzymatic Glycan Engineering of Extracellular Vesicles Using Nanomaterial-Interfaced Microfluidics","authors":"Xin Zhou, Mohit Jaiswal, Jingzhu Shi, Jiatong Guo, Sayan Kundu, Zhongwu Guo, Yong Zeng","doi":"10.1021/acsami.4c20294","DOIUrl":"https://doi.org/10.1021/acsami.4c20294","url":null,"abstract":"Extracellular vesicles (EVs) present a promising modality for numerous biological and medical applications, including therapeutics. Developing facile methods to engineer EVs is essential to meeting the rapidly expanding demand for various functionalized EVs in these applications. Herein, we developed a technology that integrates enzymatic glycoengineering and microfluidics for effective EV functionalization. This method builds on a 3D nanostructured microfluidic device to streamline a multiple-step EV engineering process, which involves a step of enzymatic reaction to install azido-sialic acid residues to glycans on EVs using a sialyltransferase and an azide-tagged sialyl donor followed by the attachment of various functionalities, such as biotin and fluorescent labels, to the resulting azido-glycans on EVs through a biocompatible click reaction. Compared to traditional EV engineering methods, we show that our technology improves the efficiency of EV glycoengineering while simplifying and expediting the workflow. Furthermore, we demonstrated the applicability of this technology to EVs derived from the cell lines of different cancer types, including A549, PC3, and COLO-1 cells. Overall, this EV engineering technology could provide a potentially useful tool for broad applications.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"23 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Polyelectrolyte Coacervate Membranes via Aqueous Phase Separation

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c18989

Shao-Hsiang Joe Hung, Meng-Chen Chiang, Jessica D. Schiffman

{"title":"Optimization of Polyelectrolyte Coacervate Membranes via Aqueous Phase Separation","authors":"Shao-Hsiang Joe Hung, Meng-Chen Chiang, Jessica D. Schiffman","doi":"10.1021/acsami.4c18989","DOIUrl":"https://doi.org/10.1021/acsami.4c18989","url":null,"abstract":"Polymeric membranes fabricated via the nonsolvent-induced phase separation process rely heavily on toxic aprotic organic solvents, like N-methyl-pyrrolidine (NMP) and dimethylformamide. We suggest that the “saloplastic” nature of polyelectrolyte complexes (PECs) makes them an excellent candidate for fabricating next-generation water purification membranes that use a more sustainable aqueous phase separation process. In this study, we investigate how the properties of PECs and their interactions with salt can form pore-containing membranes from the strong polyelectrolytes poly(sodium 4-styrenesulfonate) (PSS) and poly(diallyldimethylammonium chloride) (PDADMAC) in the presence of potassium bromide (KBr). How the single-phase polymer-rich (coacervate) dope solution and coagulation bath impacted the formation, morphology, and pure water permeance (PWP) of the membranes was systematically evaluated by using scanning electron microscopy and dead-end filtration tests. The impact of a salt annealing post-treatment process was also tested; these treated PEC membranes exhibited a PWP of 6.2 L m–2 h–1 bar–1 and a dye removal of 91.7% and 80.5% for methyl orange and methylene blue, respectively, which are on par with commercial poly(ether sulfone) nanofiltration membranes. For the first time, we have demonstrated the ability of the PEC membranes to repel Escherichia coli bacteria under static conditions. Our fundamental study of polyelectrolyte membrane pore-forming mechanisms and separation performance could help drive the future development of sustainable materials for membrane-based separations.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"271 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directly Grown Polyimide Covalent Organic Framework Films with High Electrochromic and Energy-Storage Performance

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c16702

Haolin Xie, Qingqing Qiu, Huan Li, Ping Liu, Putrakumar Balla, Xiaopeng Qi, Tongxiang Liang, Jinming Zeng

{"title":"Directly Grown Polyimide Covalent Organic Framework Films with High Electrochromic and Energy-Storage Performance","authors":"Haolin Xie, Qingqing Qiu, Huan Li, Ping Liu, Putrakumar Balla, Xiaopeng Qi, Tongxiang Liang, Jinming Zeng","doi":"10.1021/acsami.4c16702","DOIUrl":"https://doi.org/10.1021/acsami.4c16702","url":null,"abstract":"Two dimensional covalent organic framework (2D COF) films based on triphenylamine are considered to be promising electrochromic and energy-storage materials owing to their interlayer π–π electron delocalization, one-dimensional (1D) nanopores, and stable chemical structures. Triphenylamine-based 2D COF electrochromic films, nevertheless, rarely exhibit transparency and high optical contrast, which severely limited the scope of their application. In this work, two directly grown triphenylamine-based polyimide 2D COF films, TAPA-PMDA and TAPA-NTCDA PI COF, were prepared through solvothermal technology. Their morphologies were assembled into hierarchical nanoporous structures in the form of strips and gravel-like nanograins, respectively. Both the TAPA-PMDA and TAPA-NTCDA PI COF films exhibited a transparent bleached state and high optical contrast. Their optical contrasts were 77.6% at 752 nm and 60.4% at 708 nm, respectively. Interestingly, the TAPA-NTCDA PI COF film could exhibit multicolors (transparent, red-gray, and blue-gray) through regulating the contributions of the electron transition from HOMO to SOMO and HOMO-1 to SOMO of TPA+•. In addition, the TAPA-PMDA and TAPA-NTCDA PI COF films also displayed fast switching and colored/bleached times of 7.3/2.7 and 5.3/8.1 s, respectively. Remarkably, the TAPA-PMDA PI COF film also demonstrated large specific capacitance and excellent charge–discharge rate capabilities. The directly grown polyimide 2D COF films are enormously promising for high-performance electrochromic and energy-storage materials.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"19 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introducing Noncovalent Interactions in Conjugated Polymers to Enhance Backbone Coplanarity and Aggregation at the Interface to Improve Carrier Mobility

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c16351

Yiting Liu, Rui Chen, Junhang Li, Xinyu Liu, Hongxiang Li, Yanchun Han

{"title":"Introducing Noncovalent Interactions in Conjugated Polymers to Enhance Backbone Coplanarity and Aggregation at the Interface to Improve Carrier Mobility","authors":"Yiting Liu, Rui Chen, Junhang Li, Xinyu Liu, Hongxiang Li, Yanchun Han","doi":"10.1021/acsami.4c16351","DOIUrl":"https://doi.org/10.1021/acsami.4c16351","url":null,"abstract":"In organic field-effect transistors (OFETs), the high carrier mobility of conjugated polymers (CPs) is significantly influenced by the maintenance of excellent coplanarity and aggregation, especially at the interface between the organic semiconductor and dielectric layer. Unfortunately, CPs typically exhibit poor coplanarity due to the single bond rotations between donor and acceptor units. Furthermore, there is relatively little research on the coplanarity of CPs at the interface. Herein, we propose a strategy of introducing noncovalent interactions to enhance the coplanarity of the backbone and promote the aggregation of the polymer at the interface, which should lead to significant enhancements in carrier mobility. The idea is proved by incorporating different volume fractions of oleic acid (OA) into poly(indacenodithiophene-co-benzothiadiazole) (IDTBT). OA can form hydrogen bonds, which has been verified by Fourier transform infrared spectroscopy (FT-IR). OA promotes the migration of IDTBT toward the interface, thereby enhancing aggregation, as verified by film-depth-dependent light absorption spectroscopy (FLAS) and contact angle (CA) experiments. The results from film-depth-dependent Raman spectroscopy (FRS), two-dimensional grazing incidence wide-angle X-ray scattering (2D GIWAXS), atomic force microscopy (AFM), and density functional theory (DFT) calculations suggest that films treated with OA exhibit enhanced backbone coplanarity and aggregation at the interface, resulting in an increase in carrier mobility to 4.24 ± 0.11 cm2 V–1 s–1 with the addition of OA.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"110 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged Immunomodulator Delivery Boosts Monocyte Exosome Secretion and Elevates Cathelicidin/LL-37 Content

IF 9.5 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2024-12-19 DOI: 10.1021/acsami.4c20695

Dezun Ma, Yajuan Su, Navatha Shree Sharma, Grant Hatcher, Gitali Ganguli-Indra, Arup K. Indra, Adrian F. Gombart, Jingwei Xie

{"title":"Prolonged Immunomodulator Delivery Boosts Monocyte Exosome Secretion and Elevates Cathelicidin/LL-37 Content","authors":"Dezun Ma, Yajuan Su, Navatha Shree Sharma, Grant Hatcher, Gitali Ganguli-Indra, Arup K. Indra, Adrian F. Gombart, Jingwei Xie","doi":"10.1021/acsami.4c20695","DOIUrl":"https://doi.org/10.1021/acsami.4c20695","url":null,"abstract":"Human cathelicidin LL-37 offers significant benefits to the immune system and in treating various diseases, but its therapeutic potential is hindered by low activity and instability in physiological environments. Here, we introduce a strategy to boost LL-37 levels in exosomes derived from THP-1 monocytes by incubating cells with electrospun nanofibers containing immunomodulators (e.g., 1α, 25-dihydroxyvitamin D3 and VID400). Notably, the incubation with immunomodulator-loaded nanofibers not only increased LL-37 content in exosomes but also significantly enhanced the production of engineered exosomes. Moreover, these engineered exosomes demonstrated multiple biological activities, including promoting skin cell proliferation and migration, enhancing endothelial cell tube formation, and exhibiting antibacterial properties. Collectively, this study presents an approach to increasing both the yield of engineered exosomes and their LL-37 content, potentially offering a promising therapeutic option for wound healing, tissue regeneration, and infectious disease treatment.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"72 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0