Bioconjugate Chemistry Bioconjugate最新文献

Pathophysiology of syncope: current concepts and their development. 晕厥的病理生理学：当前概念及其发展。

IF 29.9 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2025-01-01 Epub Date: 2024-08-15 DOI: 10.1152/physrev.00007.2024

David G Benditt, Artur Fedorowski, Richard Sutton, J Gert van Dijk

{"title":"Pathophysiology of syncope: current concepts and their development.","authors":"David G Benditt, Artur Fedorowski, Richard Sutton, J Gert van Dijk","doi":"10.1152/physrev.00007.2024","DOIUrl":"10.1152/physrev.00007.2024","url":null,"abstract":"Syncope is a symptom in which transient loss of consciousness occurs as a consequence of a self-limited, spontaneously terminating period of cerebral hypoperfusion. Many circulatory disturbances (e.g. brady- or tachyarrhythmias, reflex cardioinhibition-vasodepression-hypotension) may trigger a syncope or near-syncope episode, and identifying the cause(s) is often challenging. Some syncope may involve multiple etiologies operating in concert, whereas in other cases multiple syncope events may be due to various differing causes at different times. In this communication, we address the current understanding of the principal contributors to syncope pathophysiology including examination of the manner in which concepts evolved, an overview of factors that constitute consciousness and loss of consciousness, and aspects of neurovascular control and communication that are impacted by cerebral hypoperfusion leading to syncope. Emphasis focuses on 1) current understanding of the way transient systemic hypotension impacts brain blood flow and brain function; 2) the complexity and temporal sequence of vascular, humoral, and cardiac factors that may accompany the most common causes of syncope; 3) the range of circumstances and disease states that may lead to syncope; and 4) clinical features associated with syncope and in particular the reflex syncope syndromes.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":" ","pages":"209-266"},"PeriodicalIF":29.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches. 肌球蛋白 II 发力机制。新实验技术和方法带来的启示。

IF 29.9 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2025-01-01 Epub Date: 2024-03-07 DOI: 10.1152/physrev.00014.2023

Dilson E Rassier, Alf Månsson

{"title":"Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches.","authors":"Dilson E Rassier, Alf Månsson","doi":"10.1152/physrev.00014.2023","DOIUrl":"10.1152/physrev.00014.2023","url":null,"abstract":"Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range of cell functions relying on the development of force and motion. When the motor attaches to actin, ATP is hydrolyzed and inorganic phosphate (Pi) and ADP are released from its active site. These reactions are coordinated with changes in the structure of myosin, promoting the so-called \"power stroke\" that causes the sliding of actin filaments. The general features of the myosin-actin interactions are well accepted, but there are critical issues that remain poorly understood, mostly due to technological limitations. In recent years, there has been a significant advance in structural, biochemical, and mechanical methods that have advanced the field considerably. New modeling approaches have also allowed researchers to understand actomyosin interactions at different levels of analysis. This paper reviews recent studies looking into the interaction between myosin II and actin filaments, which leads to power stroke and force generation. It reviews studies conducted with single myosin molecules, myosins working in filaments, muscle sarcomeres, myofibrils, and fibers. It also reviews the mathematical models that have been used to understand the mechanics of myosin II in approaches focusing on single molecules to ensembles. Finally, it includes brief sections on translational aspects, how changes in the myosin motor by mutations and/or posttranslational modifications may cause detrimental effects in diseases and aging, among other conditions, and how myosin II has become an emerging drug target.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":" ","pages":"1-93"},"PeriodicalIF":29.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating vertebrate physiology by genomic fine-tuning of GPCR functions. 通过基因组微调 GPCR 功能调节脊椎动物的生理学。

IF 29.9 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2025-01-01 Epub Date: 2024-07-25 DOI: 10.1152/physrev.00017.2024

Torsten Schöneberg

{"title":"Modulating vertebrate physiology by genomic fine-tuning of GPCR functions.","authors":"Torsten Schöneberg","doi":"10.1152/physrev.00017.2024","DOIUrl":"10.1152/physrev.00017.2024","url":null,"abstract":"G protein-coupled receptors (GPCRs) play a crucial role as membrane receptors, facilitating the communication of eukaryotic species with their environment and regulating cellular and organ interactions. Consequently, GPCRs hold immense potential in contributing to adaptation to ecological niches and responding to environmental shifts. Comparative analyses of vertebrate genomes reveal patterns of GPCR gene loss, expansion, and signatures of selection. Integrating these genomic data with insights from functional analyses of gene variants enables the interpretation of genotype-phenotype correlations. This review underscores the involvement of GPCRs in adaptive processes, presenting numerous examples of how alterations in GPCR functionality influence vertebrate physiology or, conversely, how environmental changes impact GPCR functions. The findings demonstrate that modifications in GPCR function contribute to adapting to aquatic, arid, and nocturnal habitats, influencing camouflage strategies, and specializing in particular dietary preferences. Furthermore, the adaptability of GPCR functions provides an effective mechanism in facilitating past, recent, or ongoing adaptations in animal domestication and human evolution and should be considered in therapeutic strategies and drug development.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":" ","pages":"383-439"},"PeriodicalIF":29.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives. 脂质通过离子通道和受体调节影响大脑功能：生理机制和临床视角。

IF 29.9 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2025-01-01 Epub Date: 2024-07-11 DOI: 10.1152/physrev.00004.2024

Salvatore Incontro, Maria Laura Musella, Malika Sammari, Coralie Di Scala, Jacques Fantini, Dominique Debanne

引用次数: 0

The neurobiology of parenting and infant-evoked aggression. 养育子女与婴儿攻击行为的神经生物学》（The Neurobiology of Parenting and Infant-Evoked Aggression.

IF 29.9 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2025-01-01 Epub Date: 2024-08-15 DOI: 10.1152/physrev.00036.2023

Harris S Kaplan, Patricia M Horvath, Mohammed Mostafizur Rahman, Catherine Dulac

{"title":"The neurobiology of parenting and infant-evoked aggression.","authors":"Harris S Kaplan, Patricia M Horvath, Mohammed Mostafizur Rahman, Catherine Dulac","doi":"10.1152/physrev.00036.2023","DOIUrl":"10.1152/physrev.00036.2023","url":null,"abstract":"Parenting behavior comprises a variety of adult-infant and adult-adult interactions across multiple timescales. The state transition from nonparent to parent requires an extensive reorganization of individual priorities and physiology and is facilitated by combinatorial hormone action on specific cell types that are integrated throughout interconnected and brainwide neuronal circuits. In this review, we take a comprehensive approach to integrate historical and current literature on each of these topics across multiple species, with a focus on rodents. New and emerging molecular, circuit-based, and computational technologies have recently been used to address outstanding gaps in our current framework of knowledge on infant-directed behavior. This work is raising fundamental questions about the interplay between instinctive and learned components of parenting and the mutual regulation of affiliative versus agonistic infant-directed behaviors in health and disease. Whenever possible, we point to how these technologies have helped gain novel insights and opened new avenues of research into the neurobiology of parenting. We hope this review will serve as an introduction for those new to the field, a comprehensive resource for those already studying parenting, and a guidepost for designing future studies.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":" ","pages":"315-381"},"PeriodicalIF":29.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The calculating brain. 会计算的大脑

IF 29.9 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2025-01-01 Epub Date: 2024-08-08 DOI: 10.1152/physrev.00014.2024

Andreas Nieder

{"title":"The calculating brain.","authors":"Andreas Nieder","doi":"10.1152/physrev.00014.2024","DOIUrl":"10.1152/physrev.00014.2024","url":null,"abstract":"The human brain possesses neural networks and mechanisms enabling the representation of numbers, basic arithmetic operations, and mathematical reasoning. Without the ability to represent numerical quantity and perform calculations, our scientifically and technically advanced culture would not exist. However, the origins of numerical abilities are grounded in an intuitive understanding of quantity deeply rooted in biology. Nevertheless, more advanced symbolic arithmetic skills require a cultural background with formal mathematical education. In the past two decades, cognitive neuroscience has seen significant progress in understanding the workings of the calculating brain through various methods and model systems. This review begins by exploring the mental and neuronal representations of nonsymbolic numerical quantity and then progresses to symbolic representations acquired in childhood. During arithmetic operations (addition, subtraction, multiplication, and division), these representations are processed and transformed according to arithmetic rules and principles, leveraging different mental strategies and types of arithmetic knowledge that can be dissociated in the brain. Although it was once believed that number processing and calculation originated from the language faculty, it is now evident that mathematical and linguistic abilities are primarily processed independently in the brain. Understanding how the healthy brain processes numerical information is crucial for gaining insights into debilitating numerical disorders, including acquired conditions like acalculia and learning-related calculation disorders such as developmental dyscalculia.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":" ","pages":"267-314"},"PeriodicalIF":29.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tripolar Bolalipids as Key Components of Sustained-Release Drug Delivery Systems. 作为缓释给药系统关键成分的三极磷脂。

IF 4 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2024-11-18 DOI: 10.1021/acs.bioconjchem.4c00385

Khaled Al Yaman, Sandy Al Bardawil, Maja Ostojic, Astrid Walrant, François Dolé, Sandrine Vilette, Sophie Lecomte, Isabelle Bestel, Eduard Badarau

{"title":"Tripolar Bolalipids as Key Components of Sustained-Release Drug Delivery Systems.","authors":"Khaled Al Yaman, Sandy Al Bardawil, Maja Ostojic, Astrid Walrant, François Dolé, Sandrine Vilette, Sophie Lecomte, Isabelle Bestel, Eduard Badarau","doi":"10.1021/acs.bioconjchem.4c00385","DOIUrl":"https://doi.org/10.1021/acs.bioconjchem.4c00385","url":null,"abstract":"Controlling passive diffusion through an amphiphilic membrane is a key factor for the development of future smart generations of drug delivery systems. It also plays a crucial role in understanding fundamental biological systems through the design of new artificial cell models. We report herein a new concept of bolalipids designed as key components for the control of the membrane's permeability. Built on the scaffold of two natural phospholipids connected in the terminal fatty chain region through a polar linker, this specific bola pattern adopts two extreme conformations while self-assembling in water: a bent conformation, responsible for the curvature of the membrane, and an extended conformation, responsible for decreasing the membrane's fluidity. We also designed a bolalipid possessing an ester linker in the lipidic interface that enables stabilization of highly leaky DMPC SUV-liposomes. The nanoparticles were characterized by dynamic light scattering, cryogenic transmission electron microscopy, Fourier transform infrared, differential scanning calorimetry, fluorimetry, and coarse-grained molecular dynamics in order to validate this proof of concept.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Driven Installation of Aminooxyhomolysine on Histones and Its Application for Synthesizing Stable and Site-Specific 3'-DNA-Histone Cross-Links. 组蛋白上胺氧高聚物的光驱动安装及其在合成稳定和特定位点的 3'-DNA-Histone 交叉连接中的应用。

IF 4 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2024-11-15 DOI: 10.1021/acs.bioconjchem.4c00453

Yangxue Liu, Ying Peng, Zhishuo Wang, Xiaoying Wei, Kun Yang

引用次数: 0

The UBA1-STUB1 axis mediates cancer immune escape and resistance to checkpoint blockade UBA1-STUB1 轴介导癌症免疫逃逸和对检查点阻断疗法的抗药性

IF 28.2 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2024-11-14 DOI: 10.1158/2159-8290.cd-24-0435

Yi Bao, Gabriel Cruz, Yuping Zhang, Yuanyuan Qiao, Rahul Mannan, Jing Hu, Fan Yang, Mahnoor Gondal, Miriam Shahine, Sarah Kang, Somnath Mahapatra, Alec Chu, Jae Eun Choi, Jiali Yu, Heng Lin, Stephanie J. Miner, Dan R. Robinson, Yi-Mi Wu, Yang Zheng, Xuhong Cao, Fengyun Su, Rui Wang, Noshad Hosseini, Marcin Cieslik, Ilona Kryczek, Ulka Vaishampayan, Weiping Zou, Arul M. Chinnaiyan

{"title":"The UBA1-STUB1 axis mediates cancer immune escape and resistance to checkpoint blockade","authors":"Yi Bao, Gabriel Cruz, Yuping Zhang, Yuanyuan Qiao, Rahul Mannan, Jing Hu, Fan Yang, Mahnoor Gondal, Miriam Shahine, Sarah Kang, Somnath Mahapatra, Alec Chu, Jae Eun Choi, Jiali Yu, Heng Lin, Stephanie J. Miner, Dan R. Robinson, Yi-Mi Wu, Yang Zheng, Xuhong Cao, Fengyun Su, Rui Wang, Noshad Hosseini, Marcin Cieslik, Ilona Kryczek, Ulka Vaishampayan, Weiping Zou, Arul M. Chinnaiyan","doi":"10.1158/2159-8290.cd-24-0435","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-24-0435","url":null,"abstract":"How cancer cells escape immune surveillance and resist immune checkpoint blockade (ICB) remains to be fully elucidated. By screening candidate genes frequently gained in cancer, we identified expression of ubiquitin-like modifier activating enzyme 1 (UBA1) as being the most negatively correlated with signatures related to effector CD8+ T-cells. High UBA1 expression was strongly predictive of treatment resistance and poor survival in ICB cohorts. Functional studies revealed that UBA1 mediated immune escape to promote tumor growth. Immune profiling further showed that Uba1 overexpression or depletion markedly decreased or increased functional intratumoral CD8+ T-cells, respectively. Importantly, a selective UBA1 inhibitor, TAK-243, significantly synergized with ICB in multiple syngeneic models. Mechanistically, depletion or inactivation of the UBA1-STUB1 axis stabilized a key interferon pathway component (JAK1), enhanced IFN-signaling, and elevated key immune modulators, including CXCL9, CXCL10, and MHC class I. Our study warrants clinical evaluation of the combination of UBA1 inhibitors and ICB.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":"31 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing aerosol emissions from boreal biomass burning exacerbate Arctic warming 北方生物质燃烧产生的气溶胶排放量增加加剧了北极变暖

IF 30.7 2区化学

Bioconjugate Chemistry Bioconjugate Pub Date : 2024-11-14 DOI: 10.1038/s41558-024-02176-y

Qirui Zhong, Nick Schutgens, Sander Veraverbeke, Guido R. van der Werf

引用次数: 0