受体介导的跨血脑屏障胞吞作用的抗体工程。

IF 3.9 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-10-01 DOI:10.1021/acs.bioconjchem.5c00379

Kaiyuan Guo, Dinglingge Cao, Lucia P Marchese-Thomas, Yizhou Dong

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引用次数: 0

摘要

由于血脑屏障（BBB）的限制性，治疗性抗体进入中枢神经系统（CNS）的有效递送仍然受到严重限制。受体介导的转胞作用（RMT）已成为一种有前途的策略，以加强抗体在血脑屏障的运输。在本观点中，我们强调了基于rmt的抗体递送的最新进展，特别关注三种代表性血脑屏障受体：转铁蛋白受体（TfR），胰岛素受体（InsR）和新生儿Fc受体（FcRn）。通过比较针对这些受体的抗体工程策略，我们总结了目前的进展，讨论了关键的局限性，并提出了推进cns靶向治疗抗体的方向。这一观点为选择合适的RMT靶点和优化基于抗体的中枢神经系统疾病治疗提供了有价值的见解。

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Antibody Engineering for Receptor-Mediated Transcytosis Across the Blood-Brain Barrier.

Efficient delivery of therapeutic antibodies into the central nervous system (CNS) remains severely limited by the restrictive nature of the blood-brain barrier (BBB). Receptor-mediated transcytosis (RMT) has emerged as a promising strategy to enhance antibody transport across the BBB. In this Viewpoint, we highlight recent advances in RMT-based antibody delivery, focusing specifically on three representative BBB receptors: transferrin receptor (TfR), insulin receptor (InsR), and neonatal Fc receptor (FcRn). By comparing antibody engineering strategies that target these receptors, we summarize current progress, discuss critical limitations, and suggest directions for advancing CNS-targeted therapeutic antibodies. This Viewpoint provides valuable insights for selecting appropriate RMT targets and optimizing antibody-based therapies for CNS diseases.

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.