Journal of Materials Chemistry B最新文献

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Outstanding Reviewers for Journal of Materials Chemistry B in 2023 2023 年《材料化学杂志 B》优秀审稿人。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-07-01 DOI: 10.1039/D4TB90096K
{"title":"Outstanding Reviewers for Journal of Materials Chemistry B in 2023","authors":"","doi":"10.1039/D4TB90096K","DOIUrl":"10.1039/D4TB90096K","url":null,"abstract":"<p >We would like to take this opportunity to thank all of <em>Journal of Materials Chemistry B</em>'s reviewers for helping to preserve quality and integrity in chemical science literature. We would also like to highlight the Outstanding Reviewers for <em>Journal of Materials Chemistry B</em> in 2023.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment† 将可调氧化还原反应白蛋白搭桥药物输送到肿瘤,用于癌症治疗。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-20 DOI: 10.1039/D4TB00751D
Shiwei Fu, Ajay Zheng, Lukun Wang, Jiuyan Chen, Bowen Zhao, Xiao Zhang, Victoria A. A. McKenzie, Zixin Yang, Roger M. Leblanc, Rajeev Prabhakar and Fuwu Zhang
{"title":"Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment†","authors":"Shiwei Fu, Ajay Zheng, Lukun Wang, Jiuyan Chen, Bowen Zhao, Xiao Zhang, Victoria A. A. McKenzie, Zixin Yang, Roger M. Leblanc, Rajeev Prabhakar and Fuwu Zhang","doi":"10.1039/D4TB00751D","DOIUrl":"10.1039/D4TB00751D","url":null,"abstract":"<p >This paper outlines a novel drug delivery system for highly cytotoxic mertansine (DM1) by conjugating to an albumin-binding Evans blue (EB) moiety through a tuneable responsive disulfide linker, providing valuable insights for the development of effective drug delivery systems toward cancer therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb00751d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A biocompatible pea protein isolate-derived bioink for 3D bioprinting and tissue engineering† 用于三维生物打印和组织工程的生物相容性豌豆蛋白分离衍生生物墨水。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-20 DOI: 10.1039/D4TB00781F
Xin Chen, Zheng Zhou, Mengni Yang, Shuai Zhu, Wenxiang Zhu, Jingjing Sun, Mengyi Yu, Jiaqian He, You Zuo, Wenxin Wang, Ning He, Xiaoxiao Han and Hairong Liu
{"title":"A biocompatible pea protein isolate-derived bioink for 3D bioprinting and tissue engineering†","authors":"Xin Chen, Zheng Zhou, Mengni Yang, Shuai Zhu, Wenxiang Zhu, Jingjing Sun, Mengyi Yu, Jiaqian He, You Zuo, Wenxin Wang, Ning He, Xiaoxiao Han and Hairong Liu","doi":"10.1039/D4TB00781F","DOIUrl":"10.1039/D4TB00781F","url":null,"abstract":"<p >Three-dimensional bioprinting is a potent biofabrication technique in tissue engineering but is limited by inadequate bioink availability. Plant-derived proteins are increasingly recognized as highly promising yet underutilized materials for biomedical product development and hold potential for use in bioink formulations. Herein, we report the development of a biocompatible plant protein bioink from pea protein isolate. Through pH shifting, ethanol precipitation, and lyophilization, the pea protein isolate (PPI) transformed from an insoluble to a soluble form. Next, it was modified with glycidyl methacrylate to obtain methacrylate-modified PPI (PPIGMA), which is photocurable and was used as the precursor of bioink. The mechanical and microstructural studies of the hydrogel containing 16% PPIGMA revealed a suitable compress modulus and a porous network with a pore size over 100 μm, which can facilitate nutrient and waste transportation. The PPIGMA bioink exhibited good 3D bioprinting performance in creating complex patterns and good biocompatibility as plenty of viable cells were observed in the printed samples after 3 days of incubation in the cell culture medium. No immunogenicity of the PPIGMA bioink was identified as no inflammation was observed for 4 weeks after implantation in Sprague Dawley rats. Compared with methacrylate-modified gelatin, the PPIGMA bioink significantly enhanced cartilage regeneration <em>in vitro</em> and <em>in vivo</em>, suggesting that it can be used in tissue engineering applications. In summary, the PPIGMA bioink can be potentially used for tissue engineering applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Micropatterned shape-memory polymer substrate containing hydrogen bonds creates a long-term dynamic microenvironment for regulating nerve-cell fate† 含有氢键的微图案形状记忆聚合物基底为调节神经细胞命运创造了一个长期动态微环境。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-19 DOI: 10.1039/D4TB00593G
Yilei Wang, Hao Liu, Huan Wang, Hui Xie and Shaobing Zhou
{"title":"Micropatterned shape-memory polymer substrate containing hydrogen bonds creates a long-term dynamic microenvironment for regulating nerve-cell fate†","authors":"Yilei Wang, Hao Liu, Huan Wang, Hui Xie and Shaobing Zhou","doi":"10.1039/D4TB00593G","DOIUrl":"10.1039/D4TB00593G","url":null,"abstract":"<p >Peripheral nerve injuries (PNIs) caused by mechanical contusion are frequently encountered in clinical practice, using nerve guidance conduits (NGCs) is now a promising therapy. An NGC creates a microenvironment for cell growth and differentiation, thus understanding physical and biochemical cues that can affect nerve-cell fate is a prerequisite for rationally designing NGCs. However, most of the previous works were focused on some static cues, the dynamic nature of the nerve microenvironment has not yet been well captured. Herein, we develop a micropatterned shape-memory polymer as a programmable substrate for providing a dynamic cue for nerve<strong>-</strong>cell growth. The shape-memory properties enable temporal programming of the substrate, and a dynamic microenvironment is created during standard cell culturing at 37 °C. Unlike most of the biomedical shape-memory polymers that recover rapidly at 37 °C, the proposed substrate shows a slow recovery process lasting 3–4 days and creates a long-term dynamic microenvironment. Results demonstrate that the vertically programmed substrates provide the most suitable dynamic microenvironment for PC12 cells as both the differentiation and maturity are promoted. Overall, this work provides a strategy for creating a long-term dynamic microenvironment for regulating nerve-cell fate and will inspire the rational design of NGCs for the treatment of PNIs.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Injectable thermogel constructed from self-assembled polyurethane micelle networks for 3D cell culture and wound treatment† 由自组装聚氨酯胶束网络构建的可注射热凝胶,用于三维细胞培养和伤口治疗。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-18 DOI: 10.1039/D4TB00771A
Yanjun Wang, Nan Sheng, Ao Wang, Min Wang, Yuanyang Xu, Dan Lu, Wenkai Liu, Zhen Li, Jiehua Li, Jianhui Sun and Feng Luo
{"title":"Injectable thermogel constructed from self-assembled polyurethane micelle networks for 3D cell culture and wound treatment†","authors":"Yanjun Wang, Nan Sheng, Ao Wang, Min Wang, Yuanyang Xu, Dan Lu, Wenkai Liu, Zhen Li, Jiehua Li, Jianhui Sun and Feng Luo","doi":"10.1039/D4TB00771A","DOIUrl":"10.1039/D4TB00771A","url":null,"abstract":"<p >Injectable hydrogels have attracted significant interest in the biomedical field due to their minimal invasiveness and accommodation of intricate scenes. Herein, we developed an injectable polyurethane-based thermogel platform by modulating the hydrophilic–hydrophobic balance of the segmented components with pendant PEG. The thermogelling behavior is achieved by a combination of the bridging from the hydrophilic PEG and the percolated network from the hydrophobic micelle core. Firstly, the thermogelation mechanism of this system was demonstrated by both DPD simulation and experimental investigation. The gelling temperature could be modulated by varying the solid content, the component of soft segments, and the length of the pendant PEG. We further applied 3D printing technology to prepare personalized hydrogel structures. This integration highlights the adaptability of our thermogel for fabricating complex and patient-specific constructs, presenting a significant advance in the field of regenerative medicine and tissue engineering. Subsequently, <em>in vitro</em> cell experiments demonstrated that the thermogel had good cell compatibility and could promote the proliferation and migration of L929 cells. Impressively, A549 cells could be expediently <em>in situ</em> parceled in the thermogel for three-dimensional cultivation and gain lifeful 3D cell spheres after 7 days. Further, <em>in vivo</em> experiments demonstrated that the thermogel could promote wound healing with the regeneration of capillaries and hair follicles. Ultimately, our study demonstrates the potential of hydrogels to prepare personalized hydrogel structures <em>via</em> 3D printing technology, offering innovative solutions for complex biomedical applications. This work not only provides a fresh perspective for the design of injectable thermogels but also offers a promising avenue to develop thermoresponsive waterborne polyurethane for various medical applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensing cholesterol-induced rigidity in model membranes with time-resolved fluorescence spectroscopy and microscopy† 利用时间分辨荧光光谱和显微镜感知模型膜中胆固醇诱导的刚性。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-17 DOI: 10.1039/D4TB00872C
Bidisha Biswas, Dhari Shah, Sarah J. Cox-Vázquez and Ricardo Javier Vázquez
{"title":"Sensing cholesterol-induced rigidity in model membranes with time-resolved fluorescence spectroscopy and microscopy†","authors":"Bidisha Biswas, Dhari Shah, Sarah J. Cox-Vázquez and Ricardo Javier Vázquez","doi":"10.1039/D4TB00872C","DOIUrl":"10.1039/D4TB00872C","url":null,"abstract":"<p >Here, we report the characterization of cholesterol levels on membrane fluidity with a twisted intramolecular charge transfer (TICT) membrane dye, namely DI-8-ANEPPS, using fluorescence lifetime techniques such as time-correlated single photon counting (TCSPC) and fluorescence lifetime imaging microscopy (FLIM). The characterized liposomes comprised a 3 : 1 ratio of POPC and POPG, respectively, 1% DI-8-ANEPPS, and increasing cholesterol levels from 0% to 50%. Fluorescence lifetime characterization revealed that increasing the cholesterol levels from 0% to 50% increases the fluorescence lifetime of DI-8-ANEPPS from 2.36 ns to 3.65 ns, a 55% increment. Such lengthening in the fluorescence lifetime is concomitant with reduced Stokes shifts and higher quantum yield, revealing that localized excitation (LE) dominates over TICT states with increased cholesterol levels. Fluorescence anisotropy measurements revealed a less isotropic environment in the membrane upon increasing cholesterol levels, suggesting a shift from liquid-disorder (Lα) to liquid-order (LO) upon adding cholesterol. Local electrostatic and dipole characterization experiments revealed that changes in the zeta-potential (<em>ζ</em>-potential) and transmembrane dipole potential (<em>Ψ</em><small><sub>d</sub></small>) induced by changes in cholesterol levels or the POPC : POPG ratio play a minimal role in the fluorescence lifetime outcome of DI-8-ANEPPS. Instead, these results indicate that the cholesterol's effect in restricting the degree of movement of DI-8-ANEPPS dominates its photophysics over the cholesterol effect on the local dipole strength. We envision that time-resolved spectroscopy and microscopy, coupled with TICT dyes, could be a convenient tool in exploring the complex interplay between membrane lipids, sterols, and proteins and provide novel insights into membrane fluidity, organization, and function.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of photosensitive molecules in the crosslinking of biopolymers: applications and considerations in biomaterials development† 光敏分子在生物聚合物交联中的应用:生物材料开发中的应用和考虑因素。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-15 DOI: 10.1039/D4TB00299G
Nicolas Santos, Eduardo Fuentes-Lemus and Manuel Ahumada
{"title":"Use of photosensitive molecules in the crosslinking of biopolymers: applications and considerations in biomaterials development†","authors":"Nicolas Santos, Eduardo Fuentes-Lemus and Manuel Ahumada","doi":"10.1039/D4TB00299G","DOIUrl":"10.1039/D4TB00299G","url":null,"abstract":"<p >The development of diverse types of biomaterials has significantly contributed to bringing new biomedical strategies to treat clinical conditions. Applications of these biomaterials can range from mechanical support and protection of injured tissues to joint replacement, tissue implants, and drug delivery systems. Among the strategies commonly used to prepare biomaterials, the use of electromagnetic radiation to initiate crosslinking stands out. The predominance of photo-induced polymerization methods relies on a fast, efficient, and straightforward process that can be easily adjusted to clinical needs. This strategy consists of irradiating the components that form the material with photons in the near ultraviolet–visible wavelength range (<em>i.e.</em>, ∼310 to 750 nm) in the presence of a photoactive molecule. Upon photon absorption, photosensitive molecules can generate excited species that initiate photopolymerization through different reaction mechanisms. However, this process could promote undesired side reactions depending on the target zone or treatment type (<em>e.g.</em>, oxidative stress and modification of biomolecules such as proteins and lipids). This review explores the basic concepts behind the photopolymerization process of <em>ex situ</em> and <em>in situ</em> biomaterials. Particular emphasis was put on the photosensitization initiated by the most employed photosensitizers and the photoreactions that they mediate in aqueous media. Finally, the undesired oxidation reactions at the bio-interface and potential solutions are presented.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assembled collagen films modified using polyacrylic acid with improved mechanical properties via mineralization† 使用聚丙烯酸改性的组装胶原蛋白膜通过矿化作用改善了机械性能。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-14 DOI: 10.1039/D4TB00828F
Xiaohui Chen, Zhilin Huang, Shuyun Zhang and Hong Li
{"title":"Assembled collagen films modified using polyacrylic acid with improved mechanical properties via mineralization†","authors":"Xiaohui Chen, Zhilin Huang, Shuyun Zhang and Hong Li","doi":"10.1039/D4TB00828F","DOIUrl":"10.1039/D4TB00828F","url":null,"abstract":"<p >The imperative task of enforcing collagen materials holds paramount significance in the field of hard tissue repair. We hereby present mineralized collagen fiber films <em>via</em> mineralization with improved mechanical properties. Self-extracted collagen was assembled into an array with an aligned fibrous pattern and then modified with polyacrylic acid (PAA) followed by mineralization in cationic polyacrylamide (CPAM)–SBF. Biomineralization occurred at the inner and outer surface of the assembled collagen fiber films. A tensile strength of up to 40.38 ± 3.08 MPa of mineralized collagen was obtained, for the first time, which may be attributed to the synergistic effect of polyanion and polycation on the mineralization process of assembled intrafibrillar collagen fibers. It was argued that PAA may facilitate the intra-fiber interaction of collagen, which extends the elongation at break of collagen fibers. This study introduces a pioneering approach for the preparation of mineralized collagen materials with superior mechanical properties, which would be beneficial for hard tissue repair.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in skin gene therapy: utilizing innovative dressing scaffolds for wound healing, a comprehensive review† 皮肤基因疗法的进展:利用创新敷料支架促进伤口愈合,全面综述。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-12 DOI: 10.1039/D4TB00966E
Fatemeh Karimzadeh, Elahe Soltani Fard, Akram Nadi, Rahim Malekzadeh, Fatemeh Elahian and Seyed Abbas Mirzaei
{"title":"Advances in skin gene therapy: utilizing innovative dressing scaffolds for wound healing, a comprehensive review†","authors":"Fatemeh Karimzadeh, Elahe Soltani Fard, Akram Nadi, Rahim Malekzadeh, Fatemeh Elahian and Seyed Abbas Mirzaei","doi":"10.1039/D4TB00966E","DOIUrl":"10.1039/D4TB00966E","url":null,"abstract":"<p >The skin, serving as the body's outermost layer, boasts a vast area and intricate structure, functioning as the primary barrier against external threats. Disruptions in the composition and functionality of the skin can lead to a diverse array of skin conditions, such as wounds, burns, and diabetic ulcers, along with inflammatory disorders, infections, and various types of skin cancer. These disorders not only exacerbate concerns regarding skin health and beauty but also have a significant impact on mental well-being. Due to the complexity of these disorders, conventional treatments often prove insufficient, necessitating the exploration of new therapeutic approaches. Researchers develop new therapies by deciphering these intricacies and gaining a thorough understanding of the protein networks and molecular processes in skin. A new window of opportunity has opened up for improving wound healing processes because of recent advancements in skin gene therapy. To enhance skin regeneration and healing, this extensive review investigates the use of novel dressing scaffolds in conjunction with gene therapy approaches. Scaffolds that do double duty as wound protectors and vectors for therapeutic gene delivery are being developed using innovative biomaterials. To improve cellular responses and speed healing, these state-of-the-art scaffolds allow for the targeted delivery and sustained release of genetic material. The most recent developments in gene therapy techniques include RNA interference, CRISPR-based gene editing, and the utilization of viral and non-viral vectors in conjunction with scaffolds, which were reviewed here to overcome skin disorders and wound complications. In the future, there will be rare chances to develop custom methods for skin health care thanks to the combination of modern technology and collaboration among disciplines.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carrier-free chemo-phototherapeutic nanomedicines with endo/lysosomal escape function enhance the therapeutic effect of drug molecules in tumors† 具有内/溶酶体逃逸功能的无载体化疗纳米药物可增强药物分子在肿瘤中的治疗效果。
IF 6.1 3区 医学
Journal of Materials Chemistry B Pub Date : 2024-06-12 DOI: 10.1039/D4TB00465E
Xue Feng, Calum M. Brown, Hongdi Wang, Saima Kashif, Sam Roberts, Li Yan, Tasnim Munshi, Philip J. W. Hands, Wenjun Zhang and Xianfeng Chen
{"title":"Carrier-free chemo-phototherapeutic nanomedicines with endo/lysosomal escape function enhance the therapeutic effect of drug molecules in tumors†","authors":"Xue Feng, Calum M. Brown, Hongdi Wang, Saima Kashif, Sam Roberts, Li Yan, Tasnim Munshi, Philip J. W. Hands, Wenjun Zhang and Xianfeng Chen","doi":"10.1039/D4TB00465E","DOIUrl":"10.1039/D4TB00465E","url":null,"abstract":"<p >Carrier-free nanomedicines offer advantages of extremely high drug loading capacity (&gt;80%), minimal non-drug constituent burden, and facile preparation processes. Numerous studies have proved that multimodal cancer therapy can enhance chemotherapy efficiency and mitigate multi-drug resistance (MDR) through synergistic therapeutic effects. Upon penetration into the tumor matrix, nanoparticles (NPs) are anticipated to be uptaken by cancer cells, primarily through clathrin-meditated endocytosis pathways, leading to their accumulation in endosomes/lysosomes within cells. However, endo/lysosomes exhibit a highly degradative environment for organic NPs and drug molecules, often resulting in treatment failure. Hence, this study designed a lysosomal escape mechanism with carrier-free nanomedicine, combining the chemotherapeutic drug, curcumin (Cur), and the photothermal/photodynamic therapeutic drug, indocyanine green (ICG), for synergistic cancer treatment (ICG-Cur NPs) <em>via</em> a facile preparation process. To facilitate endo/lysosomal escape, ICG-Cur NPs were modified with metal-phenolic networks (MPNs) of different thickness. The results indicate that a thick MPN coating promotes rapid endo/lysosomal escape of ICG-Cur NPs within 4 h and enhances the photothermal conversion efficiency of ICG-Cur NPs by 55.8%, significantly improving anticancer efficacy in both chemo- and photo-therapies within 3D solid tumor models. This finding underscores the critical role of endo/lysosomal escape capacity in carrier-free drug NPs for therapeutic outcomes and offers a facile solution to achieve it.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb00465e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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