Journal of Materials Chemistry B最新文献

{"title":"Advanced regenerative biomaterials for ischaemic stroke: a comprehensive therapeutic strategy","authors":"Shufang Niu, Xiaoyin Liu, Zepei Wu, An Zhu, Yunfan Zhang, Fuheng Hu, Kunlun Ding, Jun Wu and Anqi Xiao","doi":"10.1039/D5TB01227A","DOIUrl":"10.1039/D5TB01227A","url":null,"abstract":"<p >Ischaemic stroke is a major global public health problem, accounting for 62.4% of all strokes, with far-reaching consequences in terms of health burden in all regions. Nonetheless, a therapeutic window that is excessively narrow, coupled with restricted therapy modalities, has hindered the majority of patients from receiving effective treatment. With the rapid advancement of biomaterials technology, stroke treatment is being propelled towards a regenerative medicine era characterized by the tripartite collaboration of “materials, drugs, and cells”. This review systematically reviews the cutting-edge advancements of hydrogels, nanoparticles, and hybrid systems in stroke repair. Hydrogels, with their injectable and self-healing properties, precisely fit the stroke cavity, creating a microenvironment for sustained release and cellular infiltration. Nanoparticles, engineered for size and surface functionality, traverse the blood–brain barrier to achieve multi-targeted synchronous regulation. Hybrid composites of hydrogels and nanoparticles integrate the strengths of both, offering mechanical support, biodegradability, and spatiotemporally controlled drug release. Crucially, biomaterials serve as intelligent delivery vehicles for stem cells, exosomes, and genes, significantly enhancing their retention rate, differentiation efficiency, and paracrine function in the ischaemic lesion, thereby remodelling the neurovascular unit. These advancements have great promise for improving therapeutic outcomes for stroke patients.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 12020-12055"},"PeriodicalIF":6.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: An octamolybdate-metal organic framework hybrid for the efficient adsorption of histidine-rich proteins","authors":"Qing Chen, Meng-Meng Wang, Xue Hu, Xu-Wei Chen and Jian-Hua Wang","doi":"10.1039/D5TB90155C","DOIUrl":"10.1039/D5TB90155C","url":null,"abstract":"<p >Correction for ‘An octamolybdate-metal organic framework hybrid for the efficient adsorption of histidine-rich proteins’ by Qing Chen <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2016, <strong>4</strong>, 6812–6819, https://doi.org/10.1039/C6TB02090A.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11870-11871"},"PeriodicalIF":6.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90155c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Dual drug-loaded metal–phenolic networks for targeted magnetic resonance imaging and synergistic chemo–chemodynamic therapy of breast cancer","authors":"Li Xia, Cheng Ni, Huxiao Sun, Honghua Guo, Haoyu Huang, Xueyan Cao, Jindong Xia, Xiangyang Shi and Rui Guo","doi":"10.1039/D5TB90149A","DOIUrl":"10.1039/D5TB90149A","url":null,"abstract":"<p >Correction for ‘Dual drug-loaded metal–phenolic networks for targeted magnetic resonance imaging and synergistic chemo–chemodynamic therapy of breast cancer’ by Li Xia <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2024, <strong>12</strong>, 6480–6491, https://doi.org/10.1039/D4TB00462K.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11471-11472"},"PeriodicalIF":6.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90149a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface modification of polycaprolactone with sulfated alginate for enhanced binding of a heparin-binding protein","authors":"Alexandra L. Mutch, Jiankun Yang, A. Anitha, Sašo Ivanovski, Marco van de Weert and Lisbeth Grøndahl","doi":"10.1039/D5TB01292A","DOIUrl":"10.1039/D5TB01292A","url":null,"abstract":"<p >Surface modification of poly(ε-caprolactone) (PCL) to facilitate interactions with high pI proteins is a strategy used to enhance 3D PCL scaffolds for tissue engineering applications. The approach of the current study was to firstly optimise the surface modification on 2D films and then apply to 3D scaffolds. Melt-pressed PCL films were grafted with 2-aminoethyl methacrylate <em>via</em> gamma radiation induced grafting to introduce amine functional groups to the substrate surfaces. The effect of different grafting conditions including monomer concentration, radiation dose, solvent and solution pH on the degree of grafting was evaluated using contact angle measurements and X-ray photoelectron spectroscopy. The optimised grafting conditions ensured the grafts had a hydrodynamic radius of &lt;5 nm to allow clearance from the body after degradation of the PCL material. Solution binding studies of the polymers alginate, sulfated alginate (S-Alg), and heparin with the high p<em>I</em> heparin binding protein, lactoferrin (LF) confirmed that S-Alg is an effective heparin mimetic. This biopolymer was selected for conjugation to the amine-grafted PCL films through carbodiimide chemistry and time-of-flight secondary ion mass spectrometry was used to verify amide coupling. The stability of the surface layer was evaluated <em>in vitro</em> in buffer solution to determine that the unaltered and functional lifetime of the surface layer was at least 21 days. Binding of LF to the S-Alg modified surface was confirmed. The optimised amine grafting and S-Alg conjugation conditions were applied to 3D-printed medical-grade PCL scaffolds to demonstrate the potential clinical translation of this work.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 12257-12275"},"PeriodicalIF":6.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submicron silica particles disrupt planarian homeostasis: bridging bioaccumulation, oxidative stress, and growth–regeneration trade-offs","authors":"Maonan Wang, Can Jiang, Shuojie Li, Weiting Chen, Jingting Zhang, Yongqian Zhao, Ruixin Feng, Na Han, Guang Shu, Xiang Li and Gang Yin","doi":"10.1039/D5TB01409C","DOIUrl":"10.1039/D5TB01409C","url":null,"abstract":"<p >Silicosis is a systemic disease caused by prolonged inhalation of free silica dust. Currently, the criteria for evaluating silica toxicity remain rooted in the established fact that spherical particles below 10 μm in diameter can directly penetrate deep lung regions, ultimately leading to pulmonary dysfunction. This functional impairment represents complex pathological alterations, though its potential association with diminished regenerative capacity in lung tissues remains undetermined. Using the classical planarian regeneration model, this study systematically elucidates the size-dependent toxicological effects of silica particles on planarian regeneration, reproduction, and growth, along with their underlying mechanisms. Experimental data demonstrate an inverse correlation between the particle size and inhibitory potency on these biological processes. Bio-transmission electron microscopy analyses revealed preferential accumulation of smaller particles in digestive gland regions, inducing glandular morphological abnormalities and quantitative reduction, accompanied by compromised integrity of epidermal and muscular layers. RNA-seq further delineated the mechanistic basis of silica toxicity. Key findings establish that the size-dependent toxicity of silica particles is correlated with their bioaccumulation efficiency, oxidative stress induction, and disruption of key metabolic pathways. This research provides critical theoretical foundations for nanoparticle ecotoxicological assessments, while highlighting the necessity for reassessing potential health risks associated with submicron silica particles in food and industrial applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 12293-12305"},"PeriodicalIF":6.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium alginate/polyvinylpyrrolidone/lapatinib-loaded Zr–metal organic framework: biocompatibility evaluation and pH-responsive in vitro drug release for oral delivery applications","authors":"Sneha Rajeev, Naja Hasoon K T and Unnikrishnan Gopalakrishna Panicker","doi":"10.1039/D5TB01449B","DOIUrl":"10.1039/D5TB01449B","url":null,"abstract":"<p >Recent advancements in drug delivery systems have transformed drug administration methods to ensure precise, targeted delivery with minimal side effects. Innovations involving polymer–metal organic frameworks can significantly improve drug stability and controlled release properties. In this study, a drug delivery system based on a zirconium metal organic framework (Zr-MOF), sodium alginate (SA), and polyvinylpyrrolidone (PVP) was developed. Lapatinib, an oral anticancer drug used to treat breast cancer, was incorporated into the pores of a Zr–metal organic framework. Although lapatinib selectively inhibits HER2 receptors and cancer cell proliferation, it has limitations, primarily due to its poor oral bioavailability and side effects resulting from its toxicity. To address these issues, we embedded a drug-loaded Zr–metal organic framework in a sodium alginate (SA)/polyvinylpyrrolidone (PVP) polymer matrix. This combination has been proposed to modulate drug release characteristics, promote pH-responsive targeted drug delivery, increase stability, enhance mechanical properties (tensile strength of 6.5 MPa), improve hydrophilicity, and potentially enhance biocompatibility of the composites. <em>In vitro</em> release studies showed minimal lapatinib release (13%) over 48 h under simulated gastric conditions (pH 1.2), whereas drug release reached 91% at intestinal pH (6.8) during the same period. These findings indicate that the system can intrinsically prevent premature gastric release, emphasizing its potential to achieve high therapeutic effects at lower doses with reduced side effects. Biocompatibility assays indicated over 94% viability in the relevant cell lines after 24 and 48 h, indicating the favorable cytocompatibility of the composites. Overall, this composite platform provides controlled, sustained, and site-specific release of lapatinib, which could potentially enhance oral bioavailability, reduce dosage frequency, and systemic toxicity.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 12205-12223"},"PeriodicalIF":6.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01449b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic semiconducting polymer dots for dual targeted NIR-II phototheranostic and multimodal coordinated immunostimulatory therapy†","authors":"Jintong Guo, Xianyuan Wei, Ye Liu, Yun Li, Pu Chun Ke and Zhen Yuan","doi":"10.1039/D5TB00976F","DOIUrl":"10.1039/D5TB00976F","url":null,"abstract":"<p >Breast cancer is a global health challenge necessitating more precise and effective treatment strategies. In this study, we developed a novel drug-loaded therapeutic nanoplatform, OCPdots@CTe, which integrated near-infrared-II (NIR-II) window phototheranostic for targeted treatment of orthotopic breast tumors. The outer membrane vesicles (OMVs) can stimulate more immune responses based on precise targeting, while chelerythrine (CTe) can induce apoptosis by generating reactive oxygen species (ROS), thereby enhancing the therapeutic effect. Owing to the excellent optical properties of polymer dots (Pdots), this nanoplatform can also monitor the <em>in vivo</em> distribution of drugs with dual-module imaging. Moreover, the biomimetics significantly improved the biocompatibility of Pdots@CTe and provided precise delivery. Our results revealed that OCPdots@CTe significantly improved the outcome of breast tumor treatment with minimal side effects. Notably, we found that this combined therapy with multi-platform immune stimulation enhanced the anticancer effect. Together, this multifunctional nanoplatform offers a powerful versatile strategy for breast cancer treatment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 12234-12245"},"PeriodicalIF":6.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combating the post-antibiotic era crisis: antimicrobial peptide/peptidomimetic-integrated combination therapies and delivery systems","authors":"Jiaying Chi, Qiaoni Lin, Bingrui Jin, Jiayu Ou, Ling Jiang, Xinyu Yang, Jialiang Guo, Tingting Peng and Chao Lu","doi":"10.1039/D5TB01424G","DOIUrl":"10.1039/D5TB01424G","url":null,"abstract":"<p >Globally, new antibiotic development lags behind the rapid evolution of antibiotic-resistant bacteria. Given the extensive research and development cycles, high costs, and risks associated with new pharmaceuticals, exploring alternatives to conventional antibiotics and enhancing their efficacy and safety is a promising strategy for addressing challenges in the post-antibiotic era. Previous studies have shown that antimicrobial peptides/peptidomimetics (AMPs) primarily use a membrane-disruption mechanism distinct from conventional antibiotics to exert bactericidal effects. They exhibit broad-spectrum antibacterial activity, lower risk of drug resistance, and effectiveness against multidrug-resistant strains, making them promising alternative antimicrobials. This review adopts a synergistic therapeutic strategy perspective, initially examining the structure-dependent multimodal antimicrobial mechanisms of AMPs. Then, the advantages of AMP-integrated combination therapies over monotherapies are analyzed, alongside technological advancements in various drug delivery systems (<em>e.g.</em>, nanoparticles, hydrogels, microneedle patches, and inhaled formulations) that enhance targeting, prolong therapeutic efficacy, and reduce systemic toxicity. Finally, this study comprehensively analyzes the synergistic effects and delivery system designs of AMPs combined with small-molecule adjuvants (<em>e.g.</em>, antibiotics, quorum sensing inhibitors) and nanomaterials (<em>e.g.</em>, metal nanoparticles, photoresponsive materials) with case studies from recent literature. This review aims to promote the clinical translation of AMPs and offer new insights to address the global drug-resistance crisis.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 11996-12019"},"PeriodicalIF":6.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial nerve pathology: emerging strategies for regeneration and functional restoration","authors":"Suranji Wijekoon, Allen Zennifer, Sai Sadhananth Srinivasan, Sama Abdulmalik, Bin Duan and Sangamesh G. Kumbar","doi":"10.1039/D5TB01588J","DOIUrl":"10.1039/D5TB01588J","url":null,"abstract":"<p >Facial nerve injuries cause significant functional impairments, affect facial expressions, speech, and overall quality of life. This article explores advances in facial nerve regeneration, encompassing both conventional and emerging therapeutic strategies. The regenerative process involves Wallerian degeneration, axonal regrowth, and target muscle reinnervation, where the distal axon degrades and the proximal axon initiates sprouting to restore connectivity. Traditional treatments, including direct nerve repair, autologous grafts, nerve transfers, and rehabilitation, vary in efficacy based on injury severity and timing. Recent innovations in biomaterials, such as collagen scaffolds, synthetic polymers, and graphene-enhanced conduits, provide structural and biochemical support for nerve repair. Electrical stimulation has shown promise in accelerating regeneration by modulating neurotrophic factor expression and guiding axonal growth. Advanced therapies, including stem cell-based interventions, exosome-mediated treatments, and intensive neurorehabilitation, offer new prospects for enhanced recovery. Despite progress, challenges remain in standardizing treatments, ensuring clinical translation, and improving long-term efficacy. This review highlights preclinical models used to assess functional outcomes, discusses bioengineered materials tailored for nerve repair, and explores future directions in processed nerve allografts, bioengineered conduits, and biochemical cues to enhance neural regeneration after facial nerve injury.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 11971-11995"},"PeriodicalIF":6.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Click chemistry-driven adhesive hydrogel for efficient healing of infected wounds through multistage comprehensive management","authors":"Zheng Zheng, Ning Wang, Huiyu Yang, Xiaofei Gong, Jia Zheng, Yangyiyao Bai, Pengxin Tang, Shujiang Chen and Wenchuan Chen","doi":"10.1039/D5TB01743B","DOIUrl":"10.1039/D5TB01743B","url":null,"abstract":"<p >Infected wound treatment remains a critical challenge in clinical medicine. Although existing treatments, like local debridement, antimicrobial agents, and growth factor therapies, have demonstrated certain therapeutic effects, they primarily target only specific stages of wound healing. Moreover, the escalating issue of antibiotic resistance limits their efficacy. To address these challenges, this study employs click chemistry to develop a multifunctional composite hydrogel, aiming to provide a comprehensive and effective treatment strategy. This hydrogel hybrid system comprises methacrylated hyaluronic acid, sulfhydryl kappa-carrageenan, and tannic acid (referred to as HKT). By utilizing a one-step click chemistry strategy (thiol–ene reaction), we innovatively integrated a dynamically cross-linked network. This strategy eliminates toxic by-products while enabling sustained polyphenol release, establishing a therapeutic platform that orchestrates multistage interventions during infected wound management. The resulting composite hydrogel manifests appropriate mechanical characteristics, favorable rheological properties and strong tissue adhesiveness. Additionally, this hydrogel exhibits excellent antioxidant and antibacterial properties, with a ROS scavenging rate reaching 69.62% and an antibacterial efficacy of up to 99%. Furthermore, it demonstrates outstanding biocompatibility and a balanced ability to modulate inflammation and promote angiogenesis. <em>In vivo</em> studies reveal a significant enhancement in wound healing efficiency, with an improvement of 48.4% compared to the control group. This study provides a theoretical and practical foundation for the multistage comprehensive management of infected wound healing.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11582-11596"},"PeriodicalIF":6.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}