Journal of Materials Chemistry B最新文献

Correction: Construction and evaluation of platelet concentrate/mesoporous bioactive glass composite scaffolds for bone repair: injectable platelet-rich fibrin (i-PRF) vs. concentrated growth factors (CGF) 校正：用于骨修复的血小板浓缩物/介孔生物活性玻璃复合材料支架的构建和评价：可注射的富血小板纤维蛋白（i-PRF）与浓缩生长因子（CGF）。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-07-10 DOI: 10.1039/D5TB90110C

Yuanyuan Guo, Zhizheng Li, Mengran Ma, Lingqiang Meng and Dan Lin

引用次数: 0

Correction: Copper nanocrystalline-doped folic acid-based super carbon dots for an enhanced antitumor effect in response to tumor microenvironment stimuli 更正：铜纳米晶掺杂的叶酸基超级碳点在应对肿瘤微环境刺激时具有增强的抗肿瘤作用。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-07-04 DOI: 10.1039/D5TB90106E

Qing Xia, Ying Zhang, Hui Zhang, Xiong Zhang, Xiaodan Wu, Zhiqiang Wang, Rui Yan and Yingxue Jin

引用次数: 0

Tailored surface topographical scaffolds: a breakthrough in osteoarthritic cartilage and subchondral bone defect repair 定制表面拓扑支架：骨关节炎软骨和软骨下骨缺损修复的突破。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-07-01 DOI: 10.1039/D5TB00943J

Bowen Zheng, Jiawei Xing, Xuehan Tang, Ze He, Qingran Tang, Shibo Liu, Yin Xiao, Jiazhuang Xu, En Luo and Yao Liu

{"title":"Tailored surface topographical scaffolds: a breakthrough in osteoarthritic cartilage and subchondral bone defect repair","authors":"Bowen Zheng, Jiawei Xing, Xuehan Tang, Ze He, Qingran Tang, Shibo Liu, Yin Xiao, Jiazhuang Xu, En Luo and Yao Liu","doi":"10.1039/D5TB00943J","DOIUrl":"10.1039/D5TB00943J","url":null,"abstract":"Osteoarthritis, a common degenerative joint disorder, has consistently increased in incidence in recent years. Bioactive scaffolds with specific surface topographies have demonstrated significant therapeutic potential for addressing the complex structures of articular cartilage and subchondral bone. Key signaling pathways, notably Wnt/β-catenin and NF-κB, are critical mediators in tissue repair processes. Developing osteochondral tissue engineering requires a thorough evaluation of parameters such as biocompatibility, biodegradability, and mechanical properties. Advanced manufacturing technologies allow precise manipulation of micro- and nano-scale topological structures, providing essential mechanical support, establishing optimal cellular microenvironments, and enabling controlled delivery of therapeutic agents and growth factors. In this review, we systematically summarized the design principles of cell scaffolds in osteochondral repair, outlined the preparation methods for topological structures, and focused on the signaling pathways related to micro- and nano-scale topological structures and how they affect key biological processes of cells, such as cell adhesion, proliferation, migration, and differentiation. Furthermore, we discussed the future development of biomaterial scaffolds with unique micro- and nano-scale topological structures to guide future treatment of osteoarthritis.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 29","pages":" 8639-8652"},"PeriodicalIF":6.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporally modulated polyphenol–protein coating for accelerated healing of chronic wounds† 时空调节多酚蛋白涂层加速慢性伤口愈合。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-30 DOI: 10.1039/D5TB01078K

Linhua Li, Qingyin Li, Chunle Zhang, Zhengjiang Cao, Chang Liu, Rifang Luo, Yunbing Wang, Xiaoxi Zeng and Ping Fu

{"title":"Spatiotemporally modulated polyphenol–protein coating for accelerated healing of chronic wounds†","authors":"Linhua Li, Qingyin Li, Chunle Zhang, Zhengjiang Cao, Chang Liu, Rifang Luo, Yunbing Wang, Xiaoxi Zeng and Ping Fu","doi":"10.1039/D5TB01078K","DOIUrl":"10.1039/D5TB01078K","url":null,"abstract":"Chronic wounds are a common and serious complication. Abnormal microenvironments such as excessive oxidative stress, chronic inflammation, bacterial infection, and cellular dysfunction severely inhibit the wound healing process, leading to increased rates of amputation and mortality in diabetic patients. In this study, a novel polyphenol–activated protein coating (PDA/HK@LZM) was successfully constructed via the adsorption of lysozyme on the surface of a polyphenol nanocomposite comprising dopamine and honokiol. The coating effectively maintains the integrity of secondary and tertiary protein structures and preserves up to 91% of the lysozyme activity. Moreover, the PDA/HK@LZM coating achieves the spatiotemporal regulation of the chronic wound microenvironment. In the initial stage, lysozyme dominates the immune response by enhancing macrophage phagocytosis and modulating inflammatory factors, while honokiol synergizes with free radical scavenging and antimicrobial activity; all three synergistically enhance the wound self-cleaning function. In the repair stage, exposed honokiol regulates inflammation, polarizing macrophages from the pro-inflammatory M1-type to the anti-inflammatory M2-type and accelerating wound repair. Moreover, the release of honokiol into the microenvironment prevents the formation of vascular microthrombi, facilitating the delivery of nutrients and oxygen. Full-thickness skin wound experiments confirmed the effectiveness of the PDA/HK@LZM coating dressing in promoting rapid healing of chronic wounds. This study introduces a novel strategy for constructing polyphenol–activated protein coatings with spatiotemporal modulation wound microenvironment, opening new possibilities for the efficient treatment of chronic wounds.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 29","pages":" 8918-8938"},"PeriodicalIF":6.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PEGylated W4.6N4/WO3 nanoparticles as a near-infrared photothermal agent for effective cancer therapy† 聚乙二醇化W4.6N4/WO3纳米颗粒作为近红外光热剂用于有效的癌症治疗。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-30 DOI: 10.1039/D5TB00665A

Rui Yang, Jianping Li, Hao Song, Cong Wang and Na Xu

引用次数: 0

Wearable microfluidic immunosensors for point-of-care detection of bio-analytes: a critical review 用于即时检测生物分析物的可穿戴微流控免疫传感器：综述。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-27 DOI: 10.1039/D5TB00682A

Emadoddin Amin Sadrabadi, Foad Soleimani, Neda Naseri, Mohsen Ghiasi Tarzi and Kobra Omidfar

{"title":"Wearable microfluidic immunosensors for point-of-care detection of bio-analytes: a critical review","authors":"Emadoddin Amin Sadrabadi, Foad Soleimani, Neda Naseri, Mohsen Ghiasi Tarzi and Kobra Omidfar","doi":"10.1039/D5TB00682A","DOIUrl":"10.1039/D5TB00682A","url":null,"abstract":"Early and timely disease diagnosis is crucial for effective treatment and improved clinical outcomes. Antibodies and their fragments are among the most widely used affinity reagents in point-of-care (POC) assays because of their target specificity and affinity. Traditional immunosensors, the analytical devices utilizing antibodies as the biorecognition elements, are time-consuming and require advanced lab settings, limiting their use in POC testing. Recent research focuses on developing specific, portable, and cost-effective miniaturized diagnostic tests for various applications. Wearable immunosensors offer rapid, specific, and affordable solutions, especially in remote settings. However, they fall short in manipulating low-volume samples and multiplex detection of bioanalytes. Integrating these assays with micro/nanofabrication technologies would be beneficial to patient care because the various laboratory assays can be miniaturized and incorporated into a lab-on-a-body. This review aims to outline recent progress in developing wearable immunosensors and highlight the utility of these assays in detecting bio-analytes. Furthermore, prospects, opportunities, and remaining challenges within this research area are presented to facilitate their translation into clinical settings.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 29","pages":" 8609-8638"},"PeriodicalIF":6.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wire arc additively manufactured nitinol with excellent superelasticity for biomedical applications† 丝弧增材制造的镍钛诺具有优异的超弹性，用于生物医学应用。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-26 DOI: 10.1039/D5TB00336A

Muralidhar Yadav, Ajit Kumar, Deepak Kumar, Sagar Nilawar, Murugaiyan Amirthalingam, Satyam Suwas and Kaushik Chatterjee

{"title":"Wire arc additively manufactured nitinol with excellent superelasticity for biomedical applications†","authors":"Muralidhar Yadav, Ajit Kumar, Deepak Kumar, Sagar Nilawar, Murugaiyan Amirthalingam, Satyam Suwas and Kaushik Chatterjee","doi":"10.1039/D5TB00336A","DOIUrl":"10.1039/D5TB00336A","url":null,"abstract":"Despite some recent successes in the additive manufacturing of nitinol alloys, these parts exhibit poor superelasticity compared to wrought parts, limiting their applications in biomedical devices. In this work, wire arc additive manufacturing (WAAM) was used for processing superelastic biomedical grade nitinol wire as the feedstock material on a Ti-6Al-4V substrate. Nitinol prepared by WAAM was subjected to different controlled heat treatments to improve the superelasticity. Optical microscopy and scanning electron microscopy revealed microstructural anisotropy with columnar to equiaxed grains from the bottom to the top layer of the as-fabricated alloy, which did not alter with heat treatment. X-ray diffraction and transmission electron microscopy confirmed the presence of B2 austenite as the major phase along with NiTi2, Ni3Ti, and Ni4Ti3 precipitates. Af temperatures lie between 20 and 30 °C and are favorable for biomedical applications. Due to 〈001〉 oriented grains revealed by electron backscatter diffraction, nitinol prepared by WAAM, when subjected to an optimized heat treatment schedule, demonstrated excellent superelastic recovery of 98%, which is remarkably higher than reported earlier and similar to wrought alloy. Additionally, the results of cell studies indicated that the nitinol surface better supported cell attachment following heat treatment and was comparable to that of as-cast nitinol. These findings have important implications in establishing WAAM as a viable fabrication route to prepare biomedical implants, wherein additively manufactured parts can be subjected to post-fabrication heat treatments to alleviate limitations of additive manufacturing and prepare implants of desired biomechanical performance.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 29","pages":" 8844-8865"},"PeriodicalIF":6.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decellularized small intestinal hydrogel-encapsulated BMSCs attenuate dextran sulfate sodium-induced colitis in mice via immunomodulation and tissue repair 脱细胞小肠水凝胶包封的骨髓间充质干细胞通过免疫调节和组织修复减轻硫酸葡聚糖钠诱导的小鼠结肠炎。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-26 DOI: 10.1039/D5TB00706B

Qiaoting Zeng, Huimin Xiao, Yuan Chen, Zhihua Xiao, Yuhong Ren and Qin Liu

{"title":"Decellularized small intestinal hydrogel-encapsulated BMSCs attenuate dextran sulfate sodium-induced colitis in mice via immunomodulation and tissue repair","authors":"Qiaoting Zeng, Huimin Xiao, Yuan Chen, Zhihua Xiao, Yuhong Ren and Qin Liu","doi":"10.1039/D5TB00706B","DOIUrl":"10.1039/D5TB00706B","url":null,"abstract":"The treatment of inflammatory bowel disease (IBD) urgently requires effective and safe strategies, and mesenchymal stem cell (MSC)-based therapy has emerged as a research focus due to its immunomodulatory and tissue-repairing capabilities. To enhance the therapeutic efficacy of MSCs, this study developed a decellularized small intestinal (dSI) hydrogel delivery system to encapsulate rat bone marrow-derived MSCs (rBMSCs) for targeted rectal administration to colitis lesions in mice. Results demonstrated that the dSI hydrogel significantly improved the in vivo survival rate of rBMSCs and effectively alleviated dextran sulfate sodium (DSS)-induced colitis symptoms. The dSI hydrogel significantly improved rBMSCs survival in vivo and ameliorated DSS-induced colitis by: suppression of pro-inflammatory cytokines and myeloperoxidase (MPO) expression; restoration of intestinal barrier function and promotion of mucosal regeneration. The dSI hydrogel outperformed conventional PLGA-PEG-PLGA hydrogels in tissue repair due to its superior bioactivity, biocompatibility, biodegradability, and mechanical properties, while its low immunogenicity ensured therapeutic safety. The combined treatment mitigated inflammation, oxidative stress, and tissue damage through multi-target synergistic effects, offering a novel therapeutic approach for IBD. Future studies should further investigate the interaction mechanisms between dSI hydrogel and rBMSCs, optimize dosing regimens, and employ single-cell RNA sequencing to elucidate MSC-mediated immunomodulation in the gut microenvironment. This study provides experimental evidence for the clinical translation of dSI hydrogel-based MSC therapy, highlighting its potential as a promising strategy for IBD treatment.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 29","pages":" 8819-8832"},"PeriodicalIF":6.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanically active biomaterials for tissue repair and regeneration 用于组织修复和再生的机械活性生物材料。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-26 DOI: 10.1039/D5TB01180A

Wenzhen Gao, Lian Wang, Qing Zhao, Chenchen Zhou, Bo Huang and Guiting Liu

引用次数: 0

A near-infrared aggregation-induced emission photosensitizer with mitochondria specificity enhances radiotherapy for cancer stem cells ablation† 一种具有线粒体特异性的近红外聚集诱导发射光敏剂增强了癌症干细胞消融的放疗效果。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-25 DOI: 10.1039/D5TB00817D

Rong Wang, Shiquan Deng, Zeming Liu, Zixiang Meng, Shunqiong Long, Lianrui Hu, Xiumei Tian, Tianfu Zhang and Xing-Jie Liang

{"title":"A near-infrared aggregation-induced emission photosensitizer with mitochondria specificity enhances radiotherapy for cancer stem cells ablation†","authors":"Rong Wang, Shiquan Deng, Zeming Liu, Zixiang Meng, Shunqiong Long, Lianrui Hu, Xiumei Tian, Tianfu Zhang and Xing-Jie Liang","doi":"10.1039/D5TB00817D","DOIUrl":"10.1039/D5TB00817D","url":null,"abstract":"Multifunctional fluorescent molecules with organelle-targeting capabilities and high phototherapeutic efficacy have been regarded as promising materials for real-time tumor diagnosis and non-invasive treatment in the clinic. In this study, we developed a near-infrared (NIR) emissive photosensitizer, DACNPy+, which exhibits mitochondrial targeting ability, laser-triggered type I and type II reactive oxygen species (ROS) generation, and aggregation-induced emission (AIE) properties. After being encapsulated by platelet membranes and liposomal membranes, DACNPy+ was formulated into biomimetic nanoparticles termed DFL, which demonstrated remarkable tumor-targeting capabilities and in vivo long-term tumor tracking. Upon laser irradiation, DFL disintegrated within the lysosomes of cancer cells, releasing DACNPy+ and target mitochondria, thereby achieving mitochondria-targeted photodynamic therapy (PDT). This process resulted in mitochondrial dysfunction and disruption of cellular homeostasis. Notably, the highly efficient PDT successfully sensitized radiotherapy, forming a synergistic therapeutic system with “1 + 1 > 2” effect for effective killing of cancer stem cells and tumor ablation. This work offers a novel alternative to traditional clinical theranostics strategies.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 29","pages":" 8725-8731"},"PeriodicalIF":6.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0