Journal of Materials Chemistry B最新文献

Expression of concern: Reduced graphene oxide nanosheets decorated with AuPd bimetallic nanoparticles: a multifunctional material for photothermal therapy of cancer cells

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90185A

Gitashree Darabdhara, Manash R. Das, Volodymyr Turcheniuk, Kostiantyn Turcheniuk, Vladimir Zaitsev, Rabah Boukherroub and Sabine Szunerits

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Expression of concern: Selective isolation and eradication of E. coli associated with urinary tract infections using anti-fimbrial modified magnetic reduced graphene oxide nanoheaters

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90186J

Fatima Halouane, Roxana Jijie, Dalila Meziane, Chengnan Li, Santosh K. Singh, Julie Bouckaert, Jean Jurazek, Sreekumar Kurungot, Alexandre Barras, Musen Li, Rabah Boukherroub and Sabine Szunerits

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Expression of concern: Particle-based photodynamic therapy based on indocyanine green modified plasmonic nanostructures for inactivation of a Crohn's disease-associated Escherichia coli strain

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90194K

Roxana Jijie, Tetiana Dumych, Li Chengnan, Julie Bouckaert, Kostiantyn Turcheniuk, Charles-Henri Hage, Laurent Heliot, Benoit Cudennec, Nicoleta Dumitrascu, Rabah Boukherroub and Sabine Szunerits

引用次数: 0

Introduction to targeted biomedical applications of nanomaterials

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90187H

Dhiraj Bhatia, Mukesh Dhanka, Anjali Awasthi, Kamlendra Awasthi and Kaushik Chatterjee

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Expression of concern: Plasmonic photothermal destruction of uropathogenic E. coli with reduced graphene oxide and core/shell nanocomposites of gold nanorods/reduced graphene oxide

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90184C

Kostiantyn Turcheniuk, Charles-Henri Hage, Jolanda Spadavecchia, Aritz Yanguas Serrano, Iban Larroulet, Amaia Pesquera, Amaia Zurutuza, Mariano Gonzalez Pisfil, Laurent Héliot, Julie Boukaert, Rabah Boukherroub and Sabine Szunerits

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Correction: Understanding selective sensing of human serum albumin using a D–π–A probe: a photophysical and computational approach 更正：利用 D-π-A 探针了解人血清白蛋白的选择性感应：一种光物理和计算方法。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-25 DOI: 10.1039/D4TB90195A

Anamika Bandyopadhyay and Anupam Bhattacharya

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Bioactive hydrogels based on lysine dendrigrafts as crosslinkers: tailoring elastic properties to influence hMSC osteogenic differentiation† 基于赖氨酸树枝状突起作为交联剂的生物活性水凝胶：定制弹性特性以影响 hMSC 成骨分化。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-22 DOI: 10.1039/D4TB01578A

Michele Valeo, Sébastien Marie, Murielle Rémy, Tiphaine Menguy, Cédric Le Coz, Michael Molinari, Cécile Feuillie, Fabien Granier and Marie-Christine Durrieu

{"title":"Bioactive hydrogels based on lysine dendrigrafts as crosslinkers: tailoring elastic properties to influence hMSC osteogenic differentiation†","authors":"Michele Valeo, Sébastien Marie, Murielle Rémy, Tiphaine Menguy, Cédric Le Coz, Michael Molinari, Cécile Feuillie, Fabien Granier and Marie-Christine Durrieu","doi":"10.1039/D4TB01578A","DOIUrl":"10.1039/D4TB01578A","url":null,"abstract":"Dendrigrafts are multivalent macromolecules with less ordered topology and higher branching than dendrimers. Exhibiting a high density of terminal amines, poly-L-lysine dendrigrafts of the fifth generation (DGL G5) allow hydrogel formation with tailorable crosslinking density and surface modification. This work presents DGL G5 as multifunctional crosslinkers in biomimetic PEG hydrogels to favour the osteogenic differentiation of human mesenchymal stem cells (hMSCs). DGL G5 reaction with dicarboxylic-acid PEG chains yielded amide networks of variable stiffness, measured at the macro and surface nanoscale. Oscillatory rheometry and compression afforded consistent values of Young's modulus, increasing from 8 to more than 30 kPa and correlating with DGL G5 concentration. At the surface level, AFM measurements showed the same tendency but higher E values, from approximately 15 to more than 100 kPa, respectively. To promote cell adhesion and differentiation, the hydrogels were functionalised with a GRGDSPC peptide and a biomimetic of the bone morphogenetic protein 2 (BMP-2), ensuring the same grafting concentrations (between 2.15 ± 0.54 and 2.28 ± 0.23 pmols mm−2) but different hydrogel stiffness. 6 h after seeding on functionalised hydrogels in serum-less media, hMSC showed nascent adhesions on the stiffer gels and greater spreading than on glass controls with serum. After two weeks in osteogenic media, hMSC seeded on the stiffer gels showed greater spreading, more polygonal morphologies and increased levels of osteopontin, an osteoblast marker, compared to controls, which peaked on 22 kPa-gels. Together, these results demonstrate that DGL G5-PEG hydrogel bioactivity can influence the adhesion, spreading and early commitment of hMSCs.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 48","pages":" 12508-12522"},"PeriodicalIF":6.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb01578a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-responsive shape memory and self-healing hydrogels with gold and silver nanoparticles† 含有金银纳米颗粒的多反应形状记忆和自愈合水凝胶。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-18 DOI: 10.1039/D4TB01720J

Hüsna Kılıç and Deniz Ceylan

{"title":"Multi-responsive shape memory and self-healing hydrogels with gold and silver nanoparticles†","authors":"Hüsna Kılıç and Deniz Ceylan","doi":"10.1039/D4TB01720J","DOIUrl":"10.1039/D4TB01720J","url":null,"abstract":"Nanocomposite smart gels (Nc-x) with self-healing and shape memory properties were designed in different types and size nano particles with temperature or light stimuli. Nc-x networks were prepared by bulk polymerization of stearyl methacrylate (SM) and vinyl pyrrolidone (VP) in the presence of gold and silver nanoparticles. The structure, which does not contain any chemical cross-linkers, is held together by hydrophobic interactions while consisting of dipole–dipole bonds of the VP units and long alkyl groups in the side chains of the SM. Thanks to their crystalline regions, shape memory gels can self-heal with the presence of long hydrophobic chains, and furthermore, the nanoparticles (NPs) incorporated into the structure facilitate the controlled tuning of hydrophilic and hydrophobic properties. Nc-x gels have the ability to self-heal by repairing mechanical damage independently or in the presence of a stimulus, as well as transforming from a temporary form to a permanent form. In vitro experiments on human skin fibroblast cells revealed that cell viability was over 100% after 48 hours and almost complete recovery was observed in scratch experiments at the end of this period. Based on the results obtained, Nc-x gels have been shown to have the potential to be used as a non-invasive wound dressing material alternative to traditional wound closure methods.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 1","pages":" 336-353"},"PeriodicalIF":6.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and computational techniques to investigate the protein resistance of zwitterionic polymers 研究齐聚物对蛋白质抗性的实验和计算技术。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-14 DOI: 10.1039/D4TB01782J

Mengyu Lu and Nan Cheng

引用次数: 0

Enzyme-free and highly sensitive detection of human epidermal growth factor receptor-2 based on MNAzyme signal amplification in breast cancer† 基于 MNAzyme 信号放大技术的乳腺癌人表皮生长因子受体-2 的无酶高灵敏检测。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-14 DOI: 10.1039/D4TB01813C

Feifan Yin, Zhiqiang Hou, Yanheng Yao, Miao He, Yang Xiang and Zhongyun Wang

{"title":"Enzyme-free and highly sensitive detection of human epidermal growth factor receptor-2 based on MNAzyme signal amplification in breast cancer†","authors":"Feifan Yin, Zhiqiang Hou, Yanheng Yao, Miao He, Yang Xiang and Zhongyun Wang","doi":"10.1039/D4TB01813C","DOIUrl":"10.1039/D4TB01813C","url":null,"abstract":"As a common cancer biomarker, human epidermal growth factor receptor-2 (HER2) is highly expressed in breast cancer. Consequently, developing a simple and accurate HER2 sensing platform is of great significance for early diagnosis and treatment of breast cancer. Herein, we developed a rapid enzyme-free fluorescent assay biosensor based on MNAzyme signal amplification for breast cancer biomarker, HER2. The MNAzyme consists of multiple parts, including complementary DNA (cDNA) and two parts of DNAzyme (partzyme A/B). Initially, cDNA is blocked by combining with the HER2 aptamer to form a double-stranded DNA. When HER2 is present, cDNA is released as a result of the binding between HER2 and its aptamer. Due to the complementary sequences among cDNA and partzyme A/B, the MNAzyme is successfully assembled to cleave the substrate, recovering the fluorescence output. The MNAzyme biosensor exhibited a low detection limit of 0.02 ng mL−1 and excellent selectivity. Furthermore, the proposed biosensor can also change the recognition element by changing the aptamer sequence to detect various biomarkers, holding great potential for cancer diagnosis and other related biomedical applications.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 1","pages":" 305-311"},"PeriodicalIF":6.1,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0