Journal of Materials Chemistry B最新文献

Correction: Virus-like particles nanoreactors: from catalysis towards bio-applications 更正：类病毒颗粒纳米反应器：从催化到生物应用。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-06 DOI: 10.1039/D5TB90084K

Yuqing Su, Beibei Liu, Zhenkun Huang, Zihao Teng, Liulin Yang, Jie Zhu, Shuaidong Huo and Aijie Liu

引用次数: 0

Retraction: Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells 撤回：生物相容性葡聚糖包被钆掺杂氧化铈纳米颗粒作为MRI造影剂，具有高T1弛豫度和对癌细胞的选择性细胞毒性。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-05 DOI: 10.1039/D5TB90094H

A. L. Popov, M. A. Abakumov, I. V. Savintseva, A. M. Ermakov, N. R. Popova, O. S. Ivanova, D. D. Kolmanovich, A. E. Baranchikov and V. K. Ivanov

引用次数: 0

Bioelectronics: Emerging trends and applications 生物电子学：新兴趋势和应用。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-06-02 DOI: 10.1039/D5TB90077H

Anna-Maria Pappa, Eleonora Macchia, Hong Liu and George Malliaras

引用次数: 0

Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate) 用于癌症治疗的高分子纳米载体：敏感的聚(2-（二异丙基氨基）甲基丙烯酸乙酯的前景。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-05-30 DOI: 10.1039/D5TB00268K

Joana S. Ferreira, João P. Vareda, A. S. Oliveira, Jéssica S. Barbosa, Francisca Bastos, Patrícia V. Mendonça and A. C. Fonseca

{"title":"Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate)","authors":"Joana S. Ferreira, João P. Vareda, A. S. Oliveira, Jéssica S. Barbosa, Francisca Bastos, Patrícia V. Mendonça and A. C. Fonseca","doi":"10.1039/D5TB00268K","DOIUrl":"10.1039/D5TB00268K","url":null,"abstract":"Polymeric nanoparticles are extremely valuable carriers for drug/gene delivery to treat cancer, as they can protect different therapeutic agents during blood circulation while being able to deliver them at desired locations. Owing to the versatility of polymers, it is possible to fine-tune the performance of nanocarriers by changing different properties, such as chemical structure, architecture, composition and molecular weight or even by functionalising the polymers with targeting molecules. The use of pH-sensitive polymers is a very popular strategy to prepare smart carriers, taking advantage of the acidic intratumoural environment to induce hydrophobic/hydrophilic transitions that allow fast and efficient release of small drugs or genetic material. This review summarizes the contributions of the use of promising pH-sensitive poly(2-(diisopropylamino)ethyl methacrylate) (PDPA), with pKa around 6.2, in the preparation of nanocarriers for the treatment of different types of cancer through gene therapy, drug delivery or photodynamic therapy. Interest in PDPA-based copolymers for biomedical applications is increasing, as different studies have reported successful encapsulation and delivery of different therapeutic molecules with PDPA-based smart nanocarriers. In vivo studies have shown that tumour growth can be suppressed, revealing the potential of new cancer therapies.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7000-7013"},"PeriodicalIF":6.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00268k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green-light responsive fluorescein-based photoremovable protecting group: nanoparticle formulation for controlled release of bioactive molecules with real-time-monitoring ability† 基于绿光响应荧光素的光可去除保护基团：纳米颗粒配方，可控制生物活性分子的释放，具有实时监测能力。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-05-27 DOI: 10.1039/D5TB00388A

Subham Pal, Sayan Paul, Suchhanda Biswas, Batakrishna Jana and N. D. Pradeep Singh

{"title":"Green-light responsive fluorescein-based photoremovable protecting group: nanoparticle formulation for controlled release of bioactive molecules with real-time-monitoring ability†","authors":"Subham Pal, Sayan Paul, Suchhanda Biswas, Batakrishna Jana and N. D. Pradeep Singh","doi":"10.1039/D5TB00388A","DOIUrl":"10.1039/D5TB00388A","url":null,"abstract":"Dye-based photoremovable protecting groups (PRPGs) are explored for biological applications because they release bioactive molecules by absorbing light at higher wavelengths, and their self-fluorescent properties make them suitable for cellular imaging and image-guided photorelease inside the cells. Henceforth, we modified fluorescein dye to a cinnamyl-based PRPG for the release of alcohols to overcome the limitations of multiple photoproduct formation. The carboxylic acid group at C1 and the phenolic-OH group at the C6 positions in the fluorescein PRPG resulted in interesting pH-sensitive photophysical properties due to their existence in different forms (lactone, quinoid, monoanionic, dianionic) at different pHs, which is well supported by theoretical studies. Caged esters (3a–e) of fluorescein-based PRPG released the corresponding alcohols with good chemical yields and moderate photouncaging quantum yields upon exposure to green light. To enhance the biological utility, our developed fluorescein PRPG was formulated as nanoparticles (Nano-3d) having better cell penetration and accumulation. Interestingly, the fluorescein-based PRPG exhibited a change in fluorescence after photorelease ensuring its real-time monitoring ability in biological media. Furthermore, green light (525 ± 5 nm) exposure of our prepared nanoparticles (Nano-3d) released the bioactive molecule menthol within the MCF-7 breast cancer cell line causing effective cytotoxicity after photorelease. Hence, this development of a fluorescein-based PRPG can contribute to advancements in dye-based image-guided nanodrug delivery systems.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7172-7180"},"PeriodicalIF":6.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An oxidized chondroitin sulfate-crosslinked and CuCDs-loaded decellularized bovine pericardium with improved anti-coagulation, pro-endothelialization and anti-calcification properties for BHVs† 一种氧化硫酸软骨素交联和负载cuds的脱细胞牛心包，具有改善bhv的抗凝血，促内皮化和抗钙化特性。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-05-27 DOI: 10.1039/D5TB00827A

Shubin Shi, Xu Wei, Xu Peng, Xinyun Pu, Shaoxiong Feng, Xi Gao and Xixun Yu

{"title":"An oxidized chondroitin sulfate-crosslinked and CuCDs-loaded decellularized bovine pericardium with improved anti-coagulation, pro-endothelialization and anti-calcification properties for BHVs†","authors":"Shubin Shi, Xu Wei, Xu Peng, Xinyun Pu, Shaoxiong Feng, Xi Gao and Xixun Yu","doi":"10.1039/D5TB00827A","DOIUrl":"10.1039/D5TB00827A","url":null,"abstract":"With the growth of the elderly people and the development of transcatheter aortic valve replacement (TAVR) technology, bioprosthetic heart valves (BHVs) originating from the decellularized bovine pericardium (DBP) have become a favourable option for severe valvular heart disease (VHD). However, currently, available commercial bioprosthetic heart valves prepared from glutaraldehyde (GA)-crosslinked xenografts have limited durability because of various factors, including severe cytotoxicity, inflammatory response, poor pro-endothelialization ability and calcification. Therefore, the development of valve materials with better performance is urgent. In this work, we first synthesized Cu-doped carbon dots (CuCDs) with excellent biocompatibility and high stability using sodium citrate, ethylenediamine and copper chloride. Subsequently, oxidized chondroitin sulfate (OCS) was used to crosslink the decellularized bovine pericardium to obtain OCS–BP followed by loading CuCDs onto the surface of this OCS-fixed BP sample through amide bonds formed by an EDC/NHS-catalyzed reaction between the functional groups on CuCDs and OCS–BP to prepare the BHV (CuCDs–OCS–BP) with specific properties. Relevant experiments conducted both in vivo and in vitro indicate that CuCDs–OCS–BP with good stability showed improved mechanical properties, compliance and flexibility, encouraging HUVEC-cytocompatibility, excellent anti-blood cell adhesion, antithrombogenic properties, anti-inflammatory and anti-calcification properties, and a good endothelialisation ability due to the catalytic generation of endogenous nitric oxide. Overall, CuCDs–OCS–BP is a promising material for BHVs.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7196-7212"},"PeriodicalIF":6.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual model biosensor integrated with peroxidase-like activity and self-assembly for uric acid detection† 具有过氧化物酶样活性和自组装的双模型生物传感器用于尿酸检测。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-05-27 DOI: 10.1039/D5TB00692A

Dingyitai Liang, Ziqi Ding, Yushu Ding, Wenxuan Tang, Shouzhi Yang, Xiaoyu Xu, Yuning Wang and Kun Qian

{"title":"Dual model biosensor integrated with peroxidase-like activity and self-assembly for uric acid detection†","authors":"Dingyitai Liang, Ziqi Ding, Yushu Ding, Wenxuan Tang, Shouzhi Yang, Xiaoyu Xu, Yuning Wang and Kun Qian","doi":"10.1039/D5TB00692A","DOIUrl":"10.1039/D5TB00692A","url":null,"abstract":"Uric acid (UA), the final product of purine metabolism, is a crucial biomarker for gout diagnostics and highly related to various metabolic diseases. Precise detection of UA levels in serum and urine enables disease diagnosis and guides treatment. Combining the advantages of colorimetry and laser desorption/ionization mass spectrometry (LDI-MS), we developed a dual-model biosensor based on hollow Cu2O@Au nanocubes (h-Cu2O@Au NCs) for UA detection. The h-Cu2O@Au NCs demonstrated excellent peroxidase (POD)-like activity and were used to rapidly detect UA by colorimetric assay, with a linear range of 0.05–2 mM and limit of detection (LOD) of 35.71 μM. Moreover, the h-Cu2O@Au NCs achieved enrichment and detection of UA via the liquid–liquid interface self-assembly-assisted LDI-MS, with a linear range of 0.01–0.5 mM, LOD of 15.6 μM, and reproducibility of <5%. In view of its advantages, the dual-model nanoplatform based on h-Cu2O@Au NCs achieved UA detection in serum samples by colorimetry assay and in urine samples by LDI-MS, obtaining results consistent with the commercial UA assay kit (72–511 μM for serum, R2 = 0.956 and 2–9 mM for urine, R2 = 0.876), presenting potential in the rapid and sensitive detection of UA in clinic.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7146-7154"},"PeriodicalIF":6.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adhesive hydrogel barriers synergistically promote bone regeneration by self-constructing microstress and mineralization microenvironment† 黏附水凝胶屏障通过自构建微应力和矿化微环境协同促进骨再生。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-05-21 DOI: 10.1039/D5TB00154D

Senlin Chen, Mingxin Qiao, Yanhua Liu, Zihan He, Shihua Huang, Zhengyi Xu, Wenjia Xie, Jian Wang, Zhou Zhu and Qianbing Wan

{"title":"Adhesive hydrogel barriers synergistically promote bone regeneration by self-constructing microstress and mineralization microenvironment†","authors":"Senlin Chen, Mingxin Qiao, Yanhua Liu, Zihan He, Shihua Huang, Zhengyi Xu, Wenjia Xie, Jian Wang, Zhou Zhu and Qianbing Wan","doi":"10.1039/D5TB00154D","DOIUrl":"10.1039/D5TB00154D","url":null,"abstract":"Mechanical loading is a key factor in bone growth and regeneration. In bone defect repair, combining micro-stress stimulation with an excellent inorganic microenvironment offers a more effective strategy for promoting bone regeneration. In this study, guided by the strategy to create both micro-stress and a mineralization microenvironment in the bone defect area, a membrane-like hydrogel barrier (PN-GEL@BP-PE) was designed. The hydrogel barrier adheres tightly to the bone surface via polyethyleneimine/polyacrylic acid (PEI/PAA) and generates micro-stress through the volume deformation of poly(N-isopropylacrylamide) at body temperature. Meanwhile, the inorganic microenvironment that promotes bone mineralization is induced by the calcium recruitment properties of black phosphorus nanosheets (BPNs). This membrane activates the cellular micro-stress response in mesenchymal cells, working synergistically with the calcium recruitment effect of BPNs to enhance osteogenic mineralization. In vivo, the bone regeneration effect of the hydrogel membrane is approximately 50% higher than that of conventional treatments, indicating that PN-GEL@BP-PE exhibits strong osteogenic efficacy. This synergistic strategy, combining osteogenic physical and chemical microenvironments, represents a promising direction for future research.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7129-7145"},"PeriodicalIF":6.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly transparent and elastic acellular swim bladder with potential application in cornea implantation 高透明弹性脱细胞鱼鳔在角膜植入术中的潜在应用。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-05-21 DOI: 10.1039/D5TB00793C

Yue Yin, Linyu Long, Ningxin Wang, Ran Wei, Mengna Guo, Daihua Fu, Fanju Zhang, Ke Ma, Li Yang and Yunbing Wang

{"title":"Highly transparent and elastic acellular swim bladder with potential application in cornea implantation","authors":"Yue Yin, Linyu Long, Ningxin Wang, Ran Wei, Mengna Guo, Daihua Fu, Fanju Zhang, Ke Ma, Li Yang and Yunbing Wang","doi":"10.1039/D5TB00793C","DOIUrl":"10.1039/D5TB00793C","url":null,"abstract":"Corneal injury is the leading cause of blindness worldwide, and corneal transplantation remains a critical clinical treatment for restoring vision. However, the shortage of corneal donors greatly limits the application of this therapy. Although some biological corneal scaffolds such as collagen hydrogels and decellularized amniotic membranes, have emerged in recent years, their clinical efficacy is unsatisfactory because of poor tissue integration caused by the difficult suturing required and poor biomechanical properties of the scaffolds. To address these shortcomings, a decellularized swim bladder corneal scaffold was developed in this research. Specifically, using a freezing and thawing process, with 0.5% sodium deoxycholate and nuclease, the natural elastin fibers were preserved during the decellularization process, which enhanced the elastic properties of the scaffold. Dehydration and cross-linking increased the light transmittance of the decellularized swim bladder to 93.1 ± 0.8%, which was slightly higher than that of human corneas. Furthermore, cross-linking further improved the mechanical properties of the scaffolds (circumferential fracture tensile stress, elastic modulus and suture strength were 25.66 ± 4.42 MPa, 184.43 ± 23.27 MPa and 123.5 ± 2.69 gf, respectively), which were far superior to most previously reported biocorneal scaffolds reported so far. In addition, decellularized swim bladder collagen matrix scaffolds (SBCMs) supported the proliferation and adhesion of rabbit corneal epithelial cells (RCECs) and rabbit corneal stromal cells (RCSCs). Subcutaneous implantation experiments revealed that the scaffolds had a lower acute inflammatory response and better anti-degradation ability than human amniotic membranes used clinically. In summary, SBCMs have good biocompatibility, high light transmittance and excellent biomechanical properties, and can be used in the future to develop a novel generation of artificial corneas.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 23","pages":" 6689-6700"},"PeriodicalIF":6.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biogenic carbon dots derived from the microwave carbonization of amino acid mixture: cellular biocompatible, biomolecular probes, and live cell imaging agents† 微波碳化氨基酸混合物的生物碳点：细胞生物相容性、生物分子探针和活细胞显像剂。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-05-20 DOI: 10.1039/D5TB00603A

Navya P. N., Ranjith Kumar Jakku, Harishkumar Madhyastha, Ruchika Ojha, Selvakannan Periasamy, Magdalena Plebanski and Suresh K Bhargava

{"title":"Biogenic carbon dots derived from the microwave carbonization of amino acid mixture: cellular biocompatible, biomolecular probes, and live cell imaging agents†","authors":"Navya P. N., Ranjith Kumar Jakku, Harishkumar Madhyastha, Ruchika Ojha, Selvakannan Periasamy, Magdalena Plebanski and Suresh K Bhargava","doi":"10.1039/D5TB00603A","DOIUrl":"10.1039/D5TB00603A","url":null,"abstract":"Developing highly fluorescent biogenic carbon dots (CDs) as molecular probes and cellular imaging agents with excellent cellular biocompatibility and water dispersibility can advance the scope of CDs in various biomedical applications. The present work aims to produce CDs from biological precursors such as natural amino acids. Due to their molecular recognition properties, the resultant CDs exhibit biocompatibility, polar functional groups, and selective molecule sensing. Microwave (MW)-assisted carbonization of L-tryptophan, L-glutamic acid, and their mixture led to the formation of CDs. However, the CDs derived from the mix of amino acids exhibited strong emission at 450 nm, with a quantum yield of 31.3%, and showed excellent stability under wide pH conditions. These CDs have a crystalline graphitic core, predominantly derived from the carbonization of the aromatic moiety intrinsic to L-tryptophan amino acid, while the partial carbonization of L-glutamic acid led to anchor polar functional groups on the CDs surface. These CDs were established as molecular probes for sensing the biomolecule cysteamine with enhanced sensitivity and remarkable cross-selectivity among the interfering metal ions, anions, and other thiols. To demonstrate these materials' cellular biocompatibility, the cell viability of MCF-7 and fibroblast cells was studied following their exposure to CDs. The studies revealed that the fluorescent CDs did not elicit cytotoxic effects on the cells at elevated concentrations. The CDs from the mixture of amino acids were efficiently internalized by MCF-7 cells, enabling efficient imaging of live cells. Overall, this study developed biogenic and cellular biocompatible CDs with robust luminescent properties and demonstrated their applications in biomolecular sensing, cellular uptake, and imaging.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7106-7117"},"PeriodicalIF":6.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0