Journal of Materials Chemistry B最新文献

Expression of concern: Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters 表达关切：使用还原氧化石墨烯-聚乙烯亚胺柔性纳米加热器高效捕获和光热消融浮游细菌和生物膜。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-18 DOI: 10.1039/D5TB90031J

Milica Budimir, Roxana Jijie, Ran Ye, Alexandre Barras, Sorin Melinte, Alejandro Silhanek, Zoran Markovic, Sabine Szunerits and Rabah Boukherroub

引用次数: 0

A light-driven molecular motor-polypeptide conjugate supports controlled cell uptake† 光驱动分子马达-多肽共轭物支持可控细胞吸收。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-11 DOI: 10.1039/D4TB02434F

Camilla Pegoraro, Ainoa Guinart, Esther Masiá Sanchis, Daniel Doellerer, Marc C. A. Stuart, Inmaculada Conejos-Sánchez, Ben L. Feringa and María J. Vicent

{"title":"A light-driven molecular motor-polypeptide conjugate supports controlled cell uptake†","authors":"Camilla Pegoraro, Ainoa Guinart, Esther Masiá Sanchis, Daniel Doellerer, Marc C. A. Stuart, Inmaculada Conejos-Sánchez, Ben L. Feringa and María J. Vicent","doi":"10.1039/D4TB02434F","DOIUrl":"10.1039/D4TB02434F","url":null,"abstract":"While light-driven molecular motors (MMs) hold immense potential to control cell function, low biocompatibility and solubility have hampered their implementation. We developed a novel polypeptide-conjugated MM by linking a propargyl-derivatized light-driven MM to a poly-L-glutamic acid-based carrier (P) with inherent mitochondria tropism through click chemistry, denoted P-MM. P-MM effectively maintained the parental stability and unidirectional rotational capabilities of MM upon irradiation at 405 nm. Light-induced supramolecular conformational changes significantly increased cell uptake compared to non-irradiated controls while retaining the subcellular targeting capacity of P. P-MM exhibited minimal cytotoxicity and reactive oxygen species production, suggesting a non-disruptive interaction with cell membranes. Overall, we establish a connection between irradiation and enhanced biological responses, demonstrating the potential of integrating MMs with targeted polymeric nanocarriers for controlled, light-responsive behavior in biological systems and innovative applications in advanced therapeutic/diagnostic strategies.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 8","pages":" 2658-2665"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02434f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luminescent bio-sensors via co-assembly of hen egg white lysozyme with Eu3+/Tb3+-complexes†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-07 DOI: 10.1039/D4TB01766H

Min Zhang, Miao Qiu, Zengkun Li, Rui Xu, Yao Wang, Wei Wang, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore and Jianguo Tang

{"title":"Luminescent bio-sensors via co-assembly of hen egg white lysozyme with Eu3+/Tb3+-complexes†","authors":"Min Zhang, Miao Qiu, Zengkun Li, Rui Xu, Yao Wang, Wei Wang, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore and Jianguo Tang","doi":"10.1039/D4TB01766H","DOIUrl":"10.1039/D4TB01766H","url":null,"abstract":"Protein crystals have advantageous properties as framework materials, such as porosity and organized, high-density functional groups with the potential for guest specificity. Thus, protein crystal materials open up vast opportunities for fluorescent species doping and drug sensing. In this work, we explore this frontier by combining two lanthanide complexes with hen egg white lysozyme (HEWL) and directly obtaining co deposited structures in one step using an anti-solvent method different from the previous two-step method. Cross-linking of the protein was achieved using glutaraldehyde, ensuring the stability of the assembly in diverse solvent environments. The use of glutaraldehyde achieved protein cross-linking, ensuring the stability of the components in various solvent environments, including no leakage of fluorescent substances in ultrapure water and anhydrous ethanol. Differential fluorescence quenching effects of amino acids on the two doped luminescent complexes were observed. Introduction of amino acids, varying in concentration and type, resulted in distinct fluorescence enhancement or quenching effects on the protein assembly loaded with the complexes, and the detection results are reflected through different fitting equations and parameters. By exploring the application of this hybrid material for amino acid detection, this work lays the groundwork for broader applications.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3198-3208"},"PeriodicalIF":6.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Development of a tannic acid- and silicate ion-functionalized PVA–starch composite hydrogel for in situ skeletal muscle repairing

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-06 DOI: 10.1039/D5TB90025E

Longkang Li, Huipeng Li, Zhentian Diao, Huan Zhou, Yanjie Bai and Lei Yang

引用次数: 0

Correction: Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-06 DOI: 10.1039/D5TB90023A

Rui Wang, Yanfang Sun, Han Wang, Tianqi Liu, Amin Shavandi, Lei Nie, Khaydar E. Yunusov and Guohua Jiang

引用次数: 0

Retraction: Growth factors regional patterned and photoimmobilized scaffold applied to bone tissue regeneration

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-05 DOI: 10.1039/D5TB90030A

Ling-Kun Zhang, Wu-Ya Chen, Hui-Min Wang, Chao Liu, Jiecheng He, Yunzhi Tang, Yuxuan Jiao and Yan-Qing Guan

引用次数: 0

Mixed-valence vanadium-doped mesoporous bioactive glass for treatment of tumor-associated bone defects†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-05 DOI: 10.1039/D4TB02290D

Xin Liu, Peng Zhang, Mengjie Xu, Zihao Zhao, Xing Yin, Ximing Pu, Juan Wang, Xiaoming Liao, Zhongbing Huang, Shunze Cao and Guangfu Yin

{"title":"Mixed-valence vanadium-doped mesoporous bioactive glass for treatment of tumor-associated bone defects†","authors":"Xin Liu, Peng Zhang, Mengjie Xu, Zihao Zhao, Xing Yin, Ximing Pu, Juan Wang, Xiaoming Liao, Zhongbing Huang, Shunze Cao and Guangfu Yin","doi":"10.1039/D4TB02290D","DOIUrl":"10.1039/D4TB02290D","url":null,"abstract":"Vanadium is a bioactive trace element with variable valence. Its pentavalent form has been confirmed to be capable of predominantly regulating the early and mid-stage osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) without tumor inhibition, while its tetravalent form exhibits tumor inhibition but only primarily modulates late osteogenic differentiation and angiogenesis. In this study, a multifunctional bone tissue scaffold consisting of mixed-valence vanadium-doped mesoporous bioactive glass and poly(lactic-co-glycolic acid) (V(IV/V)-MBG/PLGA) was developed to simultaneously inhibit the recurrence of osteosarcoma and promote the regeneration of operative bone defects. The in vitro results showed that the V(IV) and V(V) species could be sustainably released from V(IV/V)-MBG and complementarily enhance the proliferation, osteogenic differentiation, and mineralization of BMSCs by activating multiple signaling pathways throughout the whole osteogenesis process. More importantly, the co-existence of mixed-valent vanadium species was able to continuously stimulate the generation of excessive ROS and the depletion of GSH by synergistically supplying an appropriate ratio of V(IV) and V(V) to thermodynamically and kinetically maintain the stable self-circulation of the valence state alteration, thus inducing UMR-106 cell death. In a rat model, V(IV/V)-MBG/PLGA scaffolds effectively suppressed tumor invasion and promoted bone regeneration. These results suggest that V(IV/V)-MBG/PLGA scaffolds are a promising strategy for treating tumor-associated bone defects, offering dual tumor inhibition and bone regeneration.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3138-3160"},"PeriodicalIF":6.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Phosphatidylserine-functionalized liposomes-in-microgels for delivering genistein to effectively treat ulcerative colitis 更正：磷脂酰丝氨酸功能化微凝胶脂质体可输送染料木素，有效治疗溃疡性结肠炎。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-05 DOI: 10.1039/D5TB90026C

Huijia Yan, Yanfei Li, Sihui Li, Di Wu, Yu Xu and Jiangning Hu

引用次数: 0

Regulation of the diabetic immune microenvironment by metformin-loaded strontium-doped mesoporous bioactive glass facilitates bone regeneration†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-04 DOI: 10.1039/D4TB01778A

Qing Ye, Min Zhang, Qianrui Li, Lingling Jia, Yuan Gao, He Yuan and Jiyao Li

{"title":"Regulation of the diabetic immune microenvironment by metformin-loaded strontium-doped mesoporous bioactive glass facilitates bone regeneration†","authors":"Qing Ye, Min Zhang, Qianrui Li, Lingling Jia, Yuan Gao, He Yuan and Jiyao Li","doi":"10.1039/D4TB01778A","DOIUrl":"10.1039/D4TB01778A","url":null,"abstract":"Chronic inflammation and oxidative stress in the diabetic microenvironment often hinder the healing of bone defects. Metformin (MET), the first-line diabetes medication, was shown to alter macrophage polarization toward an anti-inflammatory M2 phenotype, while simultaneously suppressing excessive reactive oxygen species (ROS) generation. Strontium-doped mesoporous bioactive glasses (SrMBG) also showed promising benefits in promoting bone regeneration. Aiming to improve the diabetic immune microenvironment within bone defects, in this study we loaded SrMBG mesopores with increasing amounts of MET. MET-loaded SrMBG (MET/SrMBG) extracts promoted macrophage differentiation toward the M2 phenotype and reduced ROS production in vitro. The possibility of facilitating osteogenic differentiation of bone marrow stromal cells (BMSCs) in vivo led us to develop 3D-printed MET/SrMBG scaffolds. Experiments utilizing a critical-size calvarium defect model in diabetic rats confirmed that implanting the MET/SrMBG scaffold enhanced bone repair owing to the effects of MET regulating M2 type macrophage polarization and mitigating oxidative stress to improve the inflammatory microenvironment.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3114-3127"},"PeriodicalIF":6.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A phlorotannin nanoparticle–hydrogel composite for enhanced oral delivery and treatment of ulcerative colitis†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-04 DOI: 10.1039/D4TB01811G

Wen Jiang, Yu Xu, Xin-Chuang Wang, Di Wu, Yi-Nan Du and Jiang-Ning Hu

{"title":"A phlorotannin nanoparticle–hydrogel composite for enhanced oral delivery and treatment of ulcerative colitis†","authors":"Wen Jiang, Yu Xu, Xin-Chuang Wang, Di Wu, Yi-Nan Du and Jiang-Ning Hu","doi":"10.1039/D4TB01811G","DOIUrl":"10.1039/D4TB01811G","url":null,"abstract":"Designing innovative strategies for oral delivery of active compounds is particularly promising for the treatment of intestinal diseases such as ulcerative colitis (UC). However, obstacles like poor therapeutic efficacy, low bioavailability, and limited biocompatibility need to be addressed. Here, via the Schiff base reaction, we developed nanoparticles based on PT (PT NPs) and incorporated them into ascorbate palmitate hydrogels (AP-Gel) to create nanoparticle–hydrogel composites (PT NPs–Gel). In vitro studies showed that PT NPs–Gel reduced pro-inflammatory cytokines (NO, iNOS, TNF-α, and IL-1β), increased the anti-inflammatory cytokine IL-10, and enhanced antioxidant enzyme activities (SOD and CAT) with effect. In the DSS-induced UC mouse model, PT NPs–Gel significantly alleviated UC symptoms, improved the length of colon, and lowered the disease activity index (DAI) score. Histological analysis indicated that PT NPs–Gel protected the colonic epithelial barrier and reduced inflammation. The PT NPs–Gel formulation utilizes the biological properties of the hydrogel carrier to improve the bioavailability of active compounds and demonstrates effective anti-inflammatory and antioxidant properties, making it a promising oral delivery system for the treatment of UC and potentially other inflammatory bowel diseases.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3080-3093"},"PeriodicalIF":6.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0