Journal of Materials Chemistry B最新文献

{"title":"Jessica Winter: Editor-in-Chief","authors":"","doi":"10.1039/D5TB90017D","DOIUrl":"10.1039/D5TB90017D","url":null,"abstract":"<p >A graphical abstract is available for this content</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3756-3757"},"PeriodicalIF":6.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the synergistic effects of Ag, Li and Sr on Zn alloys in enhancing orthopedic repair potential","authors":"Huafang Li, Luqing Ma and Yingying Li","doi":"10.1039/D5TB00111K","DOIUrl":"10.1039/D5TB00111K","url":null,"abstract":"<p >Recently, Li, which can greatly enhance the mechanical characteristics of zinc alloys, Ag, which has antibacterial properties, and Sr, which promotes bone formation, have been widely applied in biodegradable alloys. However, to our knowledge, there has been no research on the combined effects of Ag, Li, and Sr in zinc alloys. To address this, we have created a new quaternary alloy (Zn–3Ag–0.1Li–0.1Sr). The incorporation of Ag, Li, and Sr increased the yield strength (YS) of the at-cast (AC) zinc alloy to 188.83 ± 12.38 MPa. After extrusion and hot rolling, the strong plasticity of the alloy was further significantly enhanced, with ultimate tensile strength (UTS) exceeding 400 MPa, YS exceeding 350 MPa, and elongation (EL) greater than 50%. An <em>in vitro</em> cell study revealed that after three days of culture with a 50% extract, the proliferation rate of MC3T3-E1 cells was 101.527 ± 0.129%, and the cells maintained a healthy spindle-shaped appearance. The antibacterial experiments also demonstrated that the Zn–3Ag–0.1Li–0.1Sr quaternary alloy has strong antibacterial properties against both <em>Staphylococcus aureus</em> (<em>S. aureus</em>) and <em>Escherichia coli</em> (<em>E. coli</em>). Therefore, the biodegradable Zn–3Ag–0.1Li–0.1Sr quaternary alloy, which exhibits high strength, good cytocompatibility, and satisfactory antibacterial performance, has greater potential for application in the field of orthopedic repair.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 4006-4019"},"PeriodicalIF":6.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized ZIF-8 as a versatile platform for drug delivery and cancer therapy: strategies, challenges and prospects","authors":"Wenyue Gao, Xinping Han, Ling Li, Yan Xu, Min Xu, Zhu Gao and Cuijuan Wang","doi":"10.1039/D4TB02289K","DOIUrl":"10.1039/D4TB02289K","url":null,"abstract":"<p >This review discusses the functionalization strategies of ZIF-8 and challenges and future developments in ZIF-8-based platforms for drug delivery and cancer therapy. We systematically evaluate a series of innovative ZIF-8 functionalization methods, including atomic doping, introduction of targeting molecules, and biomimetic mineralization technology, to achieve precise drug release. These functionalization strategies significantly enhance the targeted delivery and controlled release properties of ZIF-8, broaden the diversity of drug delivery systems, maximize therapeutic effects, and minimize systemic toxicity. In addition, this review explores the important role of ZIF-8 in tumor therapy. Its ability to encapsulate multiple therapeutic agents and its responsiveness to the tumor microenvironment significantly improve the therapeutic effect and reduce the side effects of traditional treatments. By integrating multiple therapeutic agents and performing surface modification, ZIF-8-based platforms may provide personalized and efficient treatment options for drug-resistant or recurrent cancers. This review also comprehensively discusses the synthesis methods, drug loading capacity, and potential clinical applications of ZIF-8, emphasizing the need to optimize its large-scale production and reproducibility. In addition, further studies on the long-term biocompatibility and biodegradability of ZIF-8-based systems are essential to ensure their safety in long-term treatment. In summary, this review highlights the structural advantages and significant therapeutic potential of ZIF-8 and calls for the transition of ZIF-8 from laboratory research to clinical application to provide more targeted, efficient, and friendly cancer treatment options.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3758-3785"},"PeriodicalIF":6.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun anisotropic fiber reinforced composites for artificial heart valves","authors":"Xiuling Yang, Yifeng Chen, Qijun Wu, Haoqi Yang, Gaigai Duan, Qiliang Fu, Haonan He, Peng Zhang, Jian Ji and Shaohua Jiang","doi":"10.1039/D4TB02329C","DOIUrl":"10.1039/D4TB02329C","url":null,"abstract":"<p >Anisotropic composite valves that approximate natural heart valves are essential for the successful construction of tissue-engineered heart valves. In this work, anisotropic nylon (polyamides, PA) fiber membranes were prepared <em>via</em> electrospinning and further composited with thermoplastic polyurethane (TPU) by the impregnation method to obtain anisotropic PA/TPU composite valves. Young's modulus of the PA/TPU composite valves in the axial and radial directions along the fibers was 85.07 ± 4.22 MPa and 28.72 ± 1.16 MPa, respectively. The anisotropic PA/TPU composite valve exhibited excellent anisotropy, and its anisotropy ratio was 3.03, which was close to that of natural valves. Besides, the anisotropic PA/TPU composite valve exhibits high transparency (∼87%). The <em>in vitro</em> experiments revealed that anisotropic PA/TPU composite valves have better resistance to calcification and good blood compatibility compared with anisotropic nylon fiber membranes. Moreover, the hydrophilicity presented by the anisotropic PA/TPU composite valve reduced the adhesion of calcified particles. The good anticoagulant properties exhibited by the anisotropic PA/TPU composite valve effectively reduced the formation of thrombus after implantation. Cellular experiments and subcutaneous implantation experiments in rats showed that anisotropic PA/TPU composite valves exhibit cellular nontoxicity and good biocompatibility, contributing to cellular differentiation and growth. This preparation method has great potential in preparing anisotropic composite valves.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3918-3929"},"PeriodicalIF":6.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring processing–structure–property relationships of chemically precipitated strontium silicate particles for medical applications†","authors":"Yun-Ru Huang and Shinn-Jyh Ding","doi":"10.1039/D4TB02656J","DOIUrl":"10.1039/D4TB02656J","url":null,"abstract":"<p >Bone regeneration in the presence of osteoporosis presents a significant challenge in dental and orthopedic surgery. To tackle this issue, researchers have developed strontium-containing biomaterials. However, preventing bacterial infection is also crucial for successful surgical treatment. In this study, we delved deep into the processing to tailor the composition and structure of new strontium silicates with unique properties to address this challenge. We used chemical precipitation to prepare various strontium silicate particles using varying ammonia concentrations and Sr/Si precursor ratios. The L929 cytotoxicity, differentiation of human mesenchymal stem cells (hMSCs), biological function of RAW 264.7 macrophages, and antibacterial activity against <em>E. coli</em> and <em>S. aureus</em> were evaluated. As a result, higher ammonia concentration led to the formation of SrSiO<small>₃</small> and Sr<small>₂</small>SiO<small>₄</small> particles with smaller sizes and higher Sr/Si ratios. These particles exhibited increased antibacterial efficacy and radiopacity, promoting cell viability and osteogenic activity of hMSCs and modulating M1/M2 macrophage polarization. In conclusion, the developed strontium silicate demonstrated superior antibacterial activity, exceptional osteogenic properties, and clear visibility during procedures, making it a promising material for bone regeneration and osteoporosis treatment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3990-4005"},"PeriodicalIF":6.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive hydrogel modulator with self-regulated polyphenol release for accelerating diabetic wound healing via precise immunoregulation†","authors":"Yunfei Tan, Lei Ma, Yixuan Wu, Zeng Yi, Xiaomin Ma, Jiaxin Liu, Ye Cao and Xudong Li","doi":"10.1039/D4TB02504K","DOIUrl":"10.1039/D4TB02504K","url":null,"abstract":"<p >Nonhealing chronic wounds are intractable clinical complications of diabetes and are characterized by high protease activity, severe oxidative stress and sustained inflammatory response. In this case, the development of functional hydrogel dressings to modulate the immune microenvironment is a well-known strategy, where the precise stimuli-responsive and spatiotemporally controlled release of bioactive molecules remains a huge challenge. Herein, we developed responsive hydrogels with self-regulated bioactive molecule release based on the protease activity in diabetic wound sites, to serve as a smart immune microenvironment modulator for accelerating wound healing. The hydrogels were fabricated by grafting oxidized hyaluronic acid with epigallocatechin-3-gallate (EGCG) and gelatin methacryloyl (GelMA) under UV irradiation. Resveratrol nanoparticles were further loaded into the hydrogels before gelation to construct a polyphenol delivery system. The prepared hydrogels could achieve the on-demand release of polyphenol upon degradation by protease, as confirmed <em>via</em> degradation and polyphenol release experiments. The released polyphenol was demonstrated to have the capacity to effectively scavenge excessive free radicals, promote macrophage polarization, reduce proinflammatory factor (TNF-α) expression and augment anti-inflammatory factor (IL-10) expression <em>in vitro</em>. Additionally, <em>in vivo</em> rat wound healing model experiment results confirmed that these hydrogels promoted collagen deposition and granulation tissue regeneration, accelerating diabetic wound healing. Based on the protease-responsive degradation characteristic of the hydrogels and high protease activity in the diabetic wound microenvironment, hydrogels with exquisite polyphenol release controllability are promising candidates as dressings for diabetic wound management.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3700-3715"},"PeriodicalIF":6.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A low-cost biocompatible and biodegradable multipurpose resistive ink for monitoring biological systems†","authors":"Akshayakumar Kompa, Revathi Ravindran, Jianyu Hao and Javier G. Fernandez","doi":"10.1039/D4TB02763A","DOIUrl":"10.1039/D4TB02763A","url":null,"abstract":"<p >Flexible and biocompatible strain sensors are becoming increasingly important in fields such as health monitoring, wearable electronics, and environmental sensing because they offer significant advantages over conventional rigid systems. However, they lack the versatility and ecological and physiological biocompatibility necessary for broader integration within biological systems. Here, we describe the development of an inexpensive water-based plasticized chitosan–carbon black composite ink that can be used to produce conductive and biocompatible strain sensors. The ink can be applied to various surfaces, including skin, internal organs, and other biological tissues, using numerous methods, such as painting, dipping, and stamping. Furthermore, this unprecedented ability to attach and conform to biological surfaces allows the exploration of secondary sensing innovations, such as exploiting skin wrinkles to improve sensitivity. This study demonstrates that the ink exhibits a reliable change in electrical resistance in response to a wide range of motions, from subtle vibrations during speech and heartbeats to extensive articulations, like finger and elbow movements. This exceptional sensitivity range, biocompatibility, and the ink's low cost, biodegradability, and ease of removal enhance its applicability in sustainable, temporary, and customizable sensing solutions, highlighting its potential for versatile applications in human health monitoring, motion detection, and environmental sensing.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 10","pages":" 3295-3303"},"PeriodicalIF":6.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melt electrowriting of bioglass-laden poly(ε-caprolactone) scaffolds for bone regeneration","authors":"Ana Beatriz Gomes de Carvalho, Lais Medeiros Cardoso, Caroline Anselmi, Renan Dal-Fabbro, Tiago Moreira Bastos Campos, Alexandre Luiz Souto Borges, Guilherme de Siqueira Ferreira Anzaloni Saavedra and Marco C. Bottino","doi":"10.1039/D4TB02835J","DOIUrl":"10.1039/D4TB02835J","url":null,"abstract":"<p >Novel and promising biomaterials for bone tissue engineering have been investigated over the years. Aiming to contribute to this progress, this study developed and evaluated polycaprolactone (PCL) scaffolds with 5% (w/w) 58S-bioactive glass (58S-BG) fabricated <em>via</em> melt electrowriting (MEW). Morphological and chemical characterization of the scaffolds was conducted. The biological potential was assessed <em>in vitro</em> with alveolar bone-derived mesenchymal stem cells through cytotoxicity, adhesion, protein production, alkaline phosphatase activity, and mineral nodule formation assays. <em>In vivo</em>, scaffolds implanted in rats were analyzed for biocompatibility, inflammation, and degradation using H&amp;E staining and immunohistochemical markers for angiogenesis and macrophage polarization. Statistical analysis was performed at a 5% significance level. Appropriate fiber alignment but a higher fiber diameter was found for PCL + BG5% compared to PCL scaffolds (<em>p</em> = 0.002). EDS spectra confirmed the presence of BG's chemical components for BG-laden scaffolds, attesting to BG particle incorporation into the filaments. Raman spectroscopy evidenced the chemical nature of the BG powder, and FTIR spectra revealed –OH stretching for PCL + BG5%, evidencing its hydrophilic potential. None of the scaffolds were cytotoxic, and BG-laden formulation increased cell viability after 7 days (<em>p</em> = 0.0006), also showing greater cell adhesion/spreading over time compared to pristine PCL scaffolds. BG's presence also increased the mineral matrix formation (<em>p</em> ≤ 0.0021) over 21 days and retained ALP activity after 14 days (<em>p</em> = 0.705) compared to PCL. <em>In vivo</em>, PCL scaffolds retained fiber alignment and preserved their volume throughout the evaluation, showing minimal structural alteration. In contrast, PCL + BG5% scaffolds showed more visible structural changes at 28 days. Despite this, the PCL + BG5% formulation remained biocompatible and significantly promoted angiogenesis compared to pristine PCL scaffolds. In sum, BG-laden scaffolds were successfully melt electrowritten, retaining the scaffolds’ porous architecture, showing appropriate properties, including cell viability, adhesion, mineralized nodule deposition, biocompatibility, and angiogenesis, indicating that these materials are a promising alternative for enhancing bone tissue regeneration.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3864-3875"},"PeriodicalIF":6.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schwann cell-derived exosomes accelerate periodontal bone regeneration with osteogenesis, angiogenesis, and neurogenesis†","authors":"Ya Cui, Xiaojing Li, Xiaoya He, Xingyu Zhou, Xudong Wang, Kaili Lin and Lixia Mao","doi":"10.1039/D4TB02601B","DOIUrl":"10.1039/D4TB02601B","url":null,"abstract":"<p >Severe periodontitis frequently leads to irreversible degradation of alveolar bone. Periodontal regeneration techniques hold immense potential in reconstructing alveolar bone post periodontal diseases. Schwann cells (SCs) play a critical role in supporting, maintaining, and regenerating periodontal tissues, with SC-derived exosomes (SC-EXO) exhibiting cell homing and tissue repair capabilities. Nevertheless, the specific role of SC-EXO in periodontal bone regeneration remains unknown. To address the issue, we treated human periodontal ligament cells (hPDLCs) with SC-EXO and observed a notable increase in cell proliferation, and osteogenic and neurogenic differentiation. Moreover, SC-EXO stimulated the expression of angiogenic factors in vascular endothelial cells. In a rat model of periodontal bone defects, SC-EXO facilitated the recruitment of endogenous cells, regulated neural and vascular neogenesis, and accelerated periodontal bone regeneration. This study successfully prepared SC-EXO, which effectively promotes periodontal bone regeneration by regulating the bone healing microenvironment, potentially offering a valuable strategy for periodontal tissue engineering.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 4020-4029"},"PeriodicalIF":6.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphiphilic lysine-based glycopeptides exert antibacterial effects on Pseudomonas aeruginosa†","authors":"Shan-Shan Su, Chao-Na An, Gao-Juan Lin, Hai-Qing Li, Fangqian Yin, Xiao-Liu Li and Ke-Rang Wang","doi":"10.1039/D4TB02771J","DOIUrl":"10.1039/D4TB02771J","url":null,"abstract":"<p >The development of new antibiotics with novel antimicrobial mechanisms and strategies has attracted considerable interest. Herein, three amphiphilic lysine-based glycopeptides (<strong>SA-<small>L</small>-Gal</strong>, <strong>OA-<small>L</small>-Gal</strong> and <strong>LOA-<small>L</small>-Gal</strong>) were developed, and their antibacterial activity and inhibition effects on biofilm formation on <em>P. aeruginosa</em> were studied. <strong>SA-<small>L</small>-Gal</strong> with a stearic acid group modification exhibited better antibacterial effects than the other lysine-based glycopeptides by damaging the bacterial membrane. Furthermore, <strong>SA-<small>L</small>-Gal</strong> could effectively reduce inflammation factor expression, enhance the formation of new blood vessels, and promote the healing of <em>P. aeruginosa</em>-infected mouse wounds. This result provides insights into the development of glycomimetic drugs against <em>P. aeruginosa</em> infection.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3945-3951"},"PeriodicalIF":6.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}