Journal of Materials Chemistry B最新文献

{"title":"Broad-spectrum antimicrobial effects of hydrogen boride nanosheets†","authors":"Takeshi Nagai, Andi Mauliana, Keiichi Kobayashi, Akira Yamaguchi, Keisuke Miyazaki, Yue Yang, Jumpei Takeshita, Takeshi Fujita, Kayano Sunada, Hitoshi Ishiguro, Takahiro Kondo and Masahiro Miyauchi","doi":"10.1039/D4TB02854F","DOIUrl":"https://doi.org/10.1039/D4TB02854F","url":null,"abstract":"<p >Hydrogen boride (HB) nanosheets are novel 2D materials that have found application in various fields such as electronics, energy storage, and catalysis. The present study describes the novel antimicrobial effects of HB nanosheets. Transparent thin films of HB coated on a glass substrate inactivate pathogens, such as the omicron variant of SARS-CoV-2, influenza virus, feline calicivirus, and bacteriophages. The infectious titer of these microbes decreases to the detection limit within 10 min in the dark at room temperature. The antiviral function of the HB nanosheets is retained in the absence of moisture, mimicking the environment of dry surfaces. The HB nanosheets also inactivate bacteria and fungi such as <em>Escherichia coli</em>, <em>Staphylococcus aureus</em>, <em>Aspergillus niger</em>, and <em>Penicillium pinophilum</em>. We discussed the mechanism of the broad-spectrum antimicrobial function of HB nanosheets based on the physicochemical properties of HB nanosheets. Denaturation of microbial agents is derived from strong physicochemical interactions between the protein molecules in the pathogens and the surface of the HB films. The present study reports important new properties of HB nanosheets and demonstrates their utility in protecting against the spread of disease on a pandemic scale.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5723-5733"},"PeriodicalIF":6.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZIF-8/doxorubicin nanoparticles camouflaged with Cucurbita-derived exosomes for targeted prostate cancer therapy†","authors":"Adeleh Saffar, Ahmad Reza Bahrami, Amir Sh. Saljooghi and Maryam M. Matin","doi":"10.1039/D5TB00086F","DOIUrl":"https://doi.org/10.1039/D5TB00086F","url":null,"abstract":"<p >Development of biomimetic drug delivery systems (DDSs) holds great promise to overcome various nanoparticle-associated hindrances in cancer therapy. However, producing biomimetic nanoparticles camouflaged by animal cell-secreted exosomes presents several challenges, including low yield and some ethical considerations. Herein, we designed a biomimetic nanocarrier composed of zeolitic imidazolate framework-8 (ZIF-8) encapsulating doxorubicin (DOX) as the core and a shell of exosome-like nanoparticles (EXO) derived from <em>Cucurbita moschata</em> (CEXO). This design enhances safety and addresses some exosome limitations. The CEXO@ZIF-8/DOX platform was further functionalized with an epithelial cell adhesion molecule (EpCAM) aptamer (Apt-CEXO@ZIF-8/DOX) for targeted delivery to prostate cancer (PC) cells. After investigating the anticancer activity of CEXOs on PC-3 cells, the exosomes were utilized to coat ZIF-8/DOX. The immune evasion capability, cellular uptake, and anticancer effects of nanoplatforms were assessed. Moreover, the <em>in vivo</em> effectiveness of the targeted platform in inhibiting tumor growth and minimizing the adverse effects, was assessed using immunocompromised C57BL/6 mice bearing human PC-3 tumors. <em>Cucurbita</em> exosomes decreased cell viability and induced cell cycle arrest and apoptosis in PC-3 cells without affecting the normal cells. The biomimetic CEXO@ZIF-8/DOX improved immune escaping ability and hemocompatibility. The targeted nanocarrier, with augmented uptake and cellular toxicity in EpCAM-positive PC-3 cells, indicated active targeting efficacy mediated by the EpCAM aptamer. These results were supported by animal experiments that implied the effectiveness of Apt-CEXO@ZIF-8/DOX in inhibiting tumor growth without adverse side effects. This study introduces a novel functional nanocarrier that could potentially revolutionize DDSs by utilizing safer and more biocompatible plant exosomes.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5705-5722"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium phosphate bone cements with α-ketoglutarate polyester microspheres promote osteoporotic bone defect repair†","authors":"Zhengyang Kang, Hui Yang, Xinzhi Liang, Bin Wu, Dequan Wang, TingLiang Xiong, Luhui Zhang and Denghui Xie","doi":"10.1039/D5TB00380F","DOIUrl":"https://doi.org/10.1039/D5TB00380F","url":null,"abstract":"<p >Excessive oxidative stress and inflammation are prevalent in osteoporotic bone defects, significantly impairing the efficacy of bone regeneration in such defects. Calcium phosphate bone cements (CPC) are a commonly employed material for repairing bone defects. However, the slow rate of osteogenic mineralization and biodegradation presents a significant challenge in meeting the requirements of osteoporotic bone treatment. In this study, α-ketoglutarate (α-KG) polyester microspheres were synthesized from α-KG. By introducing different mass ratios of α-KG polyester microspheres, we constructed CPC with α-KG polyester microspheres (CPC/α-KG) that exhibited an improved microenvironment, enhanced osteogenic differentiation, and increased biomineralization. The incorporation of α-KG polyester microspheres was instrumental in enhancing the physicochemical attributes, biodegradability, biocompatibility, osteogenic differentiation potential, and biomineralization of α-KG. Mechanistically, the CPC/α-KG improves the osteogenic microenvironment by inhibiting the inflammatory response and reducing oxidative stress through the <em>PI3K/AKT</em> signaling pathway. Notably, the addition of 10 wt% α-KG polyester microspheres resulted in the optimal osteogenic capacity for CPC/α-KG. In conclusion, the modified α-KG composites show potential as effective candidates for bone defect repair and regeneration.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5655-5669"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00380f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waterborne dispersion-processed self-healing elastomers with hydrogen-bond locked hydrophobic microdomains for multifunctional applications†","authors":"Qianshu Wang, Wenbo Luan, Xiaodong Sui, Qi Sun, Mengyu Zhang, Longhai Guo, Jun Ye, Teng Qiu and Xinlin Tuo","doi":"10.1039/D5TB00502G","DOIUrl":"https://doi.org/10.1039/D5TB00502G","url":null,"abstract":"<p >The integration of self-healing properties into waterborne polyurethane (WPU) represents a significant advancement in materials chemistry. However, the practical application of self-healing WPU is often hindered by its compromised toughness, flexibility, and water resistance, as well as the challenges accompanied by complex production processes and high manufacturing costs. In this study, we propose a novel network optimization strategy that leverages the synergistic effects of multiple lateral hydrogen bonds from amide (A)–urea (U) motifs, hydrophobic aggregation of non-crystalline flexible alkyl segments, branched topology, and intrinsic intermolecular interactions within WPU. This strategy is implemented through a straightforward, stepwise chain extension synthesis of WPU, incorporating a biomass-derived chain extender (CA) designed from the condensation of cost-effective dimer acid and pentylenediamine. Remarkably, the optimized WPU exhibited bio-elastic tissue-like properties, including self-healing capability, high strength, toughness, ductility, low modulus and minimal water absorption. The self-healed material, derived from recycled film fragments, achieves an ultimate tensile strength of 41.4 MPa and an elongation at break of 1040%, with no significant stiffening or loss of elasticity. Additionally, the material demonstrated excellent interfacial adhesion, conductivity and strain sensitivity, making it suitable for use as a conductive elastomer. Furthermore, when plasticized with electrolytes, the material exhibited room-temperature self-healing within the conductive network, providing broad potential for applications in flexible electronics and related fields.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5558-5567"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive carbon dot-embedded hybrid microgels for dual sensing of iron(iii) and ciprofloxacin†","authors":"Neha Garg, Armaandeep Kaur, Savita Chaudhary and Abhijit Dan","doi":"10.1039/D5TB00315F","DOIUrl":"https://doi.org/10.1039/D5TB00315F","url":null,"abstract":"<p >A novel hybrid material was synthesized through the integration of nitrogen-doped carbon quantum dots (NCQDs) within a cationic poly(<em>N</em>-isopropylacrylamide-<em>co-N</em>-3-aminopropyl methacrylamide) (PNIPAM-<em>co</em>-APMH) microgel to create a highly sensitive, selective and multi-responsive system (NCQDs@PNIPAM-<em>co</em>-APMH) with an impressive quantum yield of 42%. The resultant hybrid microgel was shown to be an exceptional dual-functional sensor for detecting ferric ions (Fe<small>³⁺</small>) and ciprofloxacin (CIP). The detection of Fe<small>³⁺</small> was marked by a “turn-off” fluorescence response, facilitated by dynamic quenching mechanisms. In contrast, upon the introduction of CIP into the Fe<small>³⁺</small>-quenched system (Fe<small>³⁺</small>-NCQDs@PNIPAM-<em>co</em>-APMH), a “turn-on” fluorescence response was observed, with a corresponding LOD of 0.41 μM. A logic gate framework was employed to achieve sequential sensing of Fe<small>³⁺</small> and CIP in an “off–on” manner. Furthermore, the material exhibited excellent recovery rates, ranging from 86% to 108%, when applied to the analysis of real samples containing CIP. In addition to its sensing capabilities, the hybrid system was effectively utilized as a fluorescent ink, offering advanced anti-counterfeiting solutions and bolstering information security. This study highlights the substantial potential of NCQD-based hybrid materials in diverse sensing applications and their implications for practical innovations.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5577-5591"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A red-shifted donor–acceptor hemicyanine-based probe for mitochondrial pH in live cells†","authors":"Fouzia Kalim, Gandhi Sivaraman, Himanshu Vankhede, Arati Ramesh, Sufi O. Raja and Akash Gulyani","doi":"10.1039/D4TB01839G","DOIUrl":"https://doi.org/10.1039/D4TB01839G","url":null,"abstract":"<p >pH dynamically regulates diverse cellular functions and processes. At the inner mitochondrial membrane (IMM), nanoscale pH gradients generated by the electron transport chain (ETC) play a critical role in contributing to mitochondrial membrane potential that drives ATP synthesis and thermogenesis. However, tools to decouple pH gradients from the overall IMM potential in living cells are limited. This study integrates a fluorescent “benzo-indole” chromophore with a pH-sensitive “phenol” moiety into a single covalent skeleton to build a sensitive, red-shifted, cell-permeable pH probe (Mito-pH2). Mito-pH2 localizes inside mitochondria with high specificity presumably to the mitochondrial inner membrane by virtue of being an amphiphilic cation and can report dynamic changes in mitochondrial pH in living cells. Our design ensures that Mito-pH2 exhibits pH-sensitive dual-excitation and dual-emission peaks enabling ratiometric pH-sensing. Furthermore, Mito-pH2 reports an increase in pH in the pH range of 3–9 through a striking colour change from yellow to purple making it a sensitive all-purpose colorimetric pH probe. A combination of DFT calculations and spectroscopy shed light on likely sensing mechanisms including photophysics. Quantitative live-cell fluorescence imaging reveals that Mito-pH2 can detect dynamic changes in mitochondrial pH upon extracellular pH modulation with little or no measurable cytotoxicity during live imaging. Red-emitting Mito-pH2 opens new avenues of quantitative mapping of physiological mitochondrial membrane pH and significantly enhances the repertoire of environment-sensitive and low-toxicity mitochondrial probes that link mitochondrial state and micro-environment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5550-5557"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-powered sandwich-structured scaffold with dual-electroactive properties to regenerate damaged intervertebral discs after discectomy†","authors":"Jing Wang, Leizhen Huang, Tao Guo, Zheng Liu, Huilun Xu, Hao Yang, Limin Liu, Ganjun Feng and Li Zhang","doi":"10.1039/D5TB00100E","DOIUrl":"https://doi.org/10.1039/D5TB00100E","url":null,"abstract":"<p >Discectomy is the most commonly used surgery in treating herniation-induced nerve compression, but it often destroys the structural integrity and leaves a defect in the intervertebral disc (IVD), leading to re-herniation risk. Considering that electric signals play a crucial role in tissue regeneration, a dual-electroactive scaffold was fabricated to promote the repair effect of the discectomy-left IVD defect. An electroconductive scaffold (G10) was 3D-printed firstly by doping graphene to form electro-osmotic networks in a polycaprolactone (PCL) matrix, then tetragonal barium titanate (T-BT) doped polyvinylidene fluoride (PVDF) fibrous membranes (B5) with piezoelectricity were electrospun on both the upper and lower surfaces of G10 to obtain a sandwich-structured scaffold (G10B5) with both piezoelectric and electroconductive activities. The <em>in vitro</em> experimental results confirmed that the dual-electroactive G10B5 scaffold could well mimic the electroconductive properties of natural IVDs and harvest ambient mechanical energy to produce electrical stimuli, thus recruiting surrounding stem cells. Following implantation in defective IVDs of rats, the dual-electroactive scaffolds could effectively decrease the loss of cells and extracellular matrix (ECM) and maintain the composite cartilage structure of IVDs. The dual-electroactive scaffold with a sandwich structure is proposed here to provide a novel strategy for treating the IVD defects after discectomy and broaden the application of electroactive biomaterials in tissue regeneration.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 18","pages":" 5389-5402"},"PeriodicalIF":6.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing biosensing with wearable microneedle patches: innovations and applications","authors":"Navid Rabiee","doi":"10.1039/D5TB00251F","DOIUrl":"https://doi.org/10.1039/D5TB00251F","url":null,"abstract":"<p >Wearable microneedle (MN) patches have emerged as a transformative platform for biosensing, offering a minimally invasive and user-friendly approach to real-time health monitoring and disease diagnosis. Primarily designed to access interstitial fluid (ISF) through shallow skin penetration, MNs enable precise and continuous sampling of biomarkers such as glucose, lactate, and electrolytes. Additionally, recent innovations have integrated MN arrays with microfluidic and porous structures to support sweat-based analysis, where MNs act as structural or functional components in hybrid wearable systems. This review explores the design, fabrication, and functional integration of MNs into wearable devices, highlighting advances in multi-analyte detection, wireless data transmission, and self-powered sensing. Challenges related to material biocompatibility, sensor stability, scalability, and user variability are addressed, alongside emerging opportunities in microfluidics, artificial intelligence, and soft materials. Overall, MN-based biosensing platforms are poised to redefine personalized healthcare by enabling dynamic, decentralized, and accessible health monitoring.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 18","pages":" 5264-5289"},"PeriodicalIF":6.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-membrane bioinspired nanocarriers for targeted therapy of MRSA-induced acute lung injury and bacteremia†","authors":"Cheng-Yu Lin, Yen-Tzu Chang, Yu-Kuo Chung, Ahmed Alalaiwe, Huang-Ping Yu and Jia-You Fang","doi":"10.1039/D4TB02742F","DOIUrl":"https://doi.org/10.1039/D4TB02742F","url":null,"abstract":"<p >Bioinspired nanoparticles enhance the targeting of specific organs by facilitating interactions and communication at the nano-bio interface. Combining human neutrophil and lung epithelial cell membranes for nanoparticle cloaking offers distinct advantages in binding to bacteria and pulmonary epithelium, thus targeting infection-induced inflammatory areas. This study aimed to develop rifampicin-loaded biomimetic nanocarriers by wrapping a polymeric core with dual membranes derived from neutrophils and A549 cells, inheriting the membrane characteristics of the native cells. To evaluate the therapeutic efficacy of these nanocarriers, methicillin-resistant <em>Staphylococcus aureus</em> (MRSA)-induced acute lung injury (ALI) and bacteremia models were established in mice. The hybrid membrane-coated nanoparticles exhibited an average diameter of 191 nm and a nearly neutral surface charge of −2.7 mV. Zeta potential measurements, gel electrophoresis, and scanning electron microscopy (SEM) confirmed the successful decoration of the membranes on the nanoparticles. The dual membrane-coated nanoparticles were readily and rapidly ingested by lung epithelial cells within five minutes, demonstrating superior cellular uptake compared to those coated with a single membrane. SEM analysis showed significant adherence of the hybrid membrane-coated nanoparticles to the MRSA surface. The rifampicin-loaded nanocarriers effectively eradicated MRSA in its planktonic, biofilm, and intracellular forms. <em>In vivo</em> biodistribution studies in ALI mice revealed that the hybrid membrane-coated nanoparticles effectively targeted inflamed lungs, showing a two-fold increase in lung accumulation compared to the unfunctionalized nanoparticles. This targeted delivery significantly reduced the severity of lung damage caused by ALI and bacteremia, including MRSA burden, cytokine/chemokine expression, alveolar edema, and immune cell infiltration. The bioinspired nanocarriers improved the pulmonary targeting of inflamed sites and neutralized the proinflammatory mediators and toxins in the injured lung. No significant toxicity was observed in the healthy mice receiving the nanocarriers. Thus, targeted biomimetic nanocarriers, utilizing antibacterial and anti-inflammatory strategies, show promising benefits for treating pulmonary injury.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5686-5704"},"PeriodicalIF":6.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A viscosity-responsive mitochondria-targeting probe for rapid imaging of fatty liver disease†","authors":"Jiamin Liu, Hui Zhou, Deyi Li, Haotong Yin, Yi Zhou, Yuquan Ji, Yujing Zhang, Xinyue Zhang, Ben Wang, Chao Yin and Quli Fan","doi":"10.1039/D5TB00556F","DOIUrl":"https://doi.org/10.1039/D5TB00556F","url":null,"abstract":"<p >Fatty liver disease (FLD) is a leading cause of chronic liver disease worldwide, yet current diagnostic methods remain limited by low sensitivity, poor accuracy, and prolonged detection times. Recent studies have linked liver viscosity, particularly mitochondrial viscosity variations, to the progression of FLD, highlighting the need for a rapid and noninvasive viscosity-sensitive imaging tool. Herein, we present a viscosity-responsive fluorescent probe <strong>ZLCN</strong>, designed for rapid real-time imaging of fatty liver disease. <strong>ZLCN</strong> integrates an acrylonitrile rotor for viscosity sensing and a pyridine moiety for selective mitochondrial localization, enabling precise detection of viscosity alterations at the subcellular level. The probe exhibits strong fluorescence in high-viscosity environments due to restricted intramolecular rotation. <strong>ZLCN</strong> exhibits excellent viscosity responsiveness, effectively distinguishing normal and cancerous liver cells based on viscosity differences <em>in vitro</em>. Furthermore, it differentiates AML12 cells with varying viscosity levels, demonstrating its capability to monitor viscosity changes. In fatty liver models, <strong>ZLCN</strong> could produce intense fluorescence signals in fatty liver tissues and enabled rapid viscosity detection within 30 minutes, demonstrating a significant improvement over conventional imaging technique. These findings establish <strong>ZLCN</strong> as a promising tool for real-time mitochondrial viscosity monitoring, offering new avenues for early diagnosis and therapeutic assessment of viscosity-related liver diseases.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5545-5549"},"PeriodicalIF":6.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}