Journal of Materials Chemistry B最新文献

2024 Journal of Materials Chemistry Lectureship runners-up: Maxx Arguilla, University of California, Irvine, United States, and Phillip Milner, Cornell University, United States 2024 年《材料化学杂志》讲座亚军：美国加州大学欧文分校的 Maxx Arguilla 和美国康奈尔大学的 Phillip Milner。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-01-07 DOI: 10.1039/D4TB90200A

引用次数: 0

2024 Journal of Materials Chemistry Lectureship winner: Raphaële Clément, University of California, Santa Barbara, United States 2024 年《材料化学杂志》演讲奖获得者：Raphaële Clément，美国加州大学圣巴巴拉分校。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-01-07 DOI: 10.1039/D4TB90199A

引用次数: 0

Correction: Hedgehog-inspired immunomagnetic beads for high-efficient capture and release of exosomes 更正：刺猬启发的免疫磁珠，用于高效捕获和释放外泌体。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-01-06 DOI: 10.1039/D4TB90208D

Jia Cheng, Nanhang Zhu, Yujia Zhang, Yue Yu, Ke Kang, Qiangying Yi and Yao Wu

引用次数: 0

Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network† 通过超分子支持网络提高聚乙二醇基水凝胶的生物活性和力学性能。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-27 DOI: 10.1039/D4TB02002B

Yuzhu Liu, Md Shariful Islam, Anna Bakker, Zihao Li, Alaa Ajam, Jamie J. Kruzic and Kristopher A. Kilian

{"title":"Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network†","authors":"Yuzhu Liu, Md Shariful Islam, Anna Bakker, Zihao Li, Alaa Ajam, Jamie J. Kruzic and Kristopher A. Kilian","doi":"10.1039/D4TB02002B","DOIUrl":"10.1039/D4TB02002B","url":null,"abstract":"Most synthetic hydrogels are formed through radical polymerization to yield a homogenous covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both covalent assembly and supramolecular interactions. In this communication, we expand the capabilities of covalent poly(ethylene glycol) (PEG) networks through co-assembly of supramolecular peptide nanofibers. Using a peptide hydrogelator derived from the tryptophan zipper (Trpzip) motif, we demonstrate how in situ formation of nanofiber networks can tune the stiffness of PEG-based hydrogels, while also imparting shear thinning, stress relaxation, and self-healing properties. The hybrid networks show enhanced toughness and durability under tension, providing scope for use in load bearing applications. A small quantity of Trpzip peptide renders the non-adhesive PEG network adhesive, supporting adipose derived stromal cell adhesion, elongation, and growth. The integration of supramolecular networks into covalent meshworks expands the versatility of these materials, opening up new avenues for applications in biotechnology and medicine.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 4","pages":" 1286-1295"},"PeriodicalIF":6.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive zeolitic imidazolate framework nanoconjugates as synergistic drug delivery agents for cancer nanotherapeutics† 生物活性沸石咪唑酸框架纳米缀合物作为癌症纳米治疗的协同药物递送剂。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-20 DOI: 10.1039/D4TB01303D

Seyyed Mojtaba Mousavi, Wei-Hung Chiang and Ahmad Gholami

{"title":"Bioactive zeolitic imidazolate framework nanoconjugates as synergistic drug delivery agents for cancer nanotherapeutics†","authors":"Seyyed Mojtaba Mousavi, Wei-Hung Chiang and Ahmad Gholami","doi":"10.1039/D4TB01303D","DOIUrl":"10.1039/D4TB01303D","url":null,"abstract":"The increasing effective, detectable, and targeted anticancer systems are driven by the growing cancer incidence and the side effects of current drugs. Natural products like saponin and apigenin have emerged as valuable compounds for precise treatment. Recent advancements in bioactive metal–organic frameworks (MOFs) have introduced multifunctional particles suitable for cellular imaging, targeted drug delivery, and early cancer treatment. In this study, bioactive ZIF-67 and ZIF-8 materials were synthesized, incorporating zinc nitrate and natural bioactive compounds such as saponin and apigenin to sensitize and deliver the material to damaged cancer tissue. The characterization of these bioactive nanostructures involved FT-IR, TEM, EDX, FESEM, and BET analysis. The study quantified the loading and release of natural products within the ZIF structure. Cytotoxicity assessments of drug-loaded MOFs were conducted on human oral cavity carcinoma cell lines OSCC, Hep-G2, Raji, MCF-7, and PDL under in vitro conditions. Flow cytometry analysis identified the combination of bioactive ZIF-67 and saponins as the most effective in inducing apoptosis. Finally, a novel synthesis of bioactive MOF compounds was developed with dual applications: drug delivery and cancer imaging, featuring a unique attribute that minimizes side effects on normal cells.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 3","pages":" 965-984"},"PeriodicalIF":6.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering of redox-triggered polymeric lipid hybrid nanocarriers for selective drug delivery to cancer cells† 设计氧化还原触发的聚合物脂质混合纳米载体，为癌细胞提供选择性药物输送。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-18 DOI: 10.1039/D4TB01236D

B. Siva Lokesh, Suresh Ajmeera, Rajat Choudhary, Sanjaya Kumar Moharana, C. S. Purohit and V. Badireenath Konkimalla

{"title":"Engineering of redox-triggered polymeric lipid hybrid nanocarriers for selective drug delivery to cancer cells†","authors":"B. Siva Lokesh, Suresh Ajmeera, Rajat Choudhary, Sanjaya Kumar Moharana, C. S. Purohit and V. Badireenath Konkimalla","doi":"10.1039/D4TB01236D","DOIUrl":"10.1039/D4TB01236D","url":null,"abstract":"Tunable redox-sensitive polymeric-lipid hybrid nanocarriers (RS-PLHNCs) were fabricated using homogenization and nanoprecipitation methods. These nanocarriers were composed of novel redox-cholesterol with disulfide linkages and synthesized by conjugating cholesterol with dithiodipropionic acid via esterification. Berberine (BBR) was loaded into the fabricated nanocarriers to investigate the selective uptake of BBR by cancer cells as well as its release and enhanced cytotoxicity. The optimized BBR nanocarriers BBR NP-17 and -18 exhibited a spherical shape and uniform distribution, with a particle size of 124.7 ± 1.2 nm and 185.2 ± 1.6 nm and a zeta potential of −5.9 ± 2.5 mV and −20.3 ± 1.1 mV, respectively. These NCs released >80% BBR in a simulated intracellular tumor microenvironment (TME), while only 30%–45% was released under normal physiological conditions. The accelerated drug release in the TME was due to disulfide bond cleavage and ester bond hydrolysis in the presence of GSH and acidic pH, whereas under normal conditions, the NCs remained stable/undissociated. Cellular uptake studies confirmed enhanced BBR uptake in GSH-rich cancer cells (H1975) compared with normal cells (BEAS-2B and HEK293A). Following uptake, compared with the free form of the drug, the optimized nanocarriers displayed significant selective cytotoxicity and apoptosis in cancer cells by notably downregulating anti-oxidant (NFE2L2, HO-1, NQO1, and TXRND1) and anti-apoptotic (MCL-1) genes while upregulating pro-apoptotic genes (PUMA and NOXA). This resulted in increased oxidative stress, thereby inducing selective apoptosis in the GSH-rich lung cancer cells. These results suggest that the synthesized novel NCs hold great potential for specifically delivering drugs to cancer cells (with a reduced environment) while sparing normal cells, thus ensuring safe and efficient cancer therapy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 4","pages":" 1437-1458"},"PeriodicalIF":6.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and characterization of an Ag–Bi–S-based multifunctional nanotheranostic platform† 基于银铋的多功能纳米治疗平台的设计、合成和表征。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-18 DOI: 10.1039/D4TB02502D

Yuan-Yi Tan, Xin Chen, Dong-Yun Zheng, Chao Liu, Xiao-Jun Liu, Xian-Guang Lin and Chun-Nan Zhu

引用次数: 0

Jeroen Cornelissen retires as Editor-in-Chief 总编辑 Jeroen Cornelissen 退休。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-18 DOI: 10.1039/D4TB90204A

Jeroen Cornelissen

引用次数: 0

A multi-valent polymyxin-based fluorescent probe for the detection of Gram-negative infections† 一种检测革兰氏阴性感染的多价多粘菌素荧光探针。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-17 DOI: 10.1039/D4TB01786B

Richa Sharma, Maria Rodriguez-Rios, James Crossland, Maulida Septiyana, Alicia Megia-Fernandez, Maxime Klausen and Mark Bradley

引用次数: 0

Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis 新兴生物工程在子宫内膜异位症和bbb的精确诊断和治疗方面的突破。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-16 DOI: 10.1039/D4TB01755B

Yujie Peng, Meng Zhang, Jingjing Yan, Rong Wang, Yu Xin, Xiaoling Zheng, Libo Zhu, Weidong Fei and Mengdan Zhao

{"title":"Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis","authors":"Yujie Peng, Meng Zhang, Jingjing Yan, Rong Wang, Yu Xin, Xiaoling Zheng, Libo Zhu, Weidong Fei and Mengdan Zhao","doi":"10.1039/D4TB01755B","DOIUrl":"10.1039/D4TB01755B","url":null,"abstract":"Endometriosis and adenomyosis are debilitating gynecological conditions that severely affect the quality of life of women. Traditional diagnostic and treatment methods, including laparoscopic surgery and hormonal therapy, face significant limitations such as incomplete lesion detection, high recurrence rates, and adverse side effects. Emerging bioengineering technologies offer promising solutions for precise diagnosis and therapy of these diseases. Advances in biomarker detection through electrochemical immunosensors, including specific molecular markers like cytokines and growth factors, have improved their early diagnosis. Innovative imaging techniques, such as near-infrared fluorescence imaging, magnetic resonance imaging, and photoacoustic imaging, enhance lesion visualization and surgical precision. In therapeutic applications, bioengineered drug delivery systems enable targeted therapy by modifying drug carriers with ligands targeting highly expressed receptors in endometriotic lesions. Such strategies could improve drug accumulation at target sites and reduce damage to healthy tissues. Integrating external energy (including lasers, focused ultrasound, and magnetic fields) with nanoplatforms offers key benefits for treating endometriosis and adenomyosis, allowing precise delivery of energy-responsive molecules to lesions and minimizing damage to healthy tissues. Additionally, novel approaches, such as immunotherapy, gene therapy, ferroptosis induction, and synthetic lethal activation, offer new avenues for effective treatment of endometriosis and adenomyosis. Significantly, this paper discusses the advantages of precision diagnosis and treatment of endometriosis in preserving the fertility of women of reproductive age. This review highlights the potential of bioengineering breakthroughs to transform the diagnosis and management of endometriosis and adenomyosis, emphasizing their role in advancing precision medicine and improving women's health.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 3","pages":" 742-762"},"PeriodicalIF":6.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0