Journal of Materials Chemistry B最新文献

{"title":"The role of Eudragit® as a component of hydrogel formulations for medical devices†","authors":"David Esporrín-Ubieto, Ana Sofía Sonzogni, Mercedes Fernández, Arantxa Acera, Eider Matxinandiarena, Juan F. Cadavid-Vargas, Itxaso Calafel, Ruth N. Schmarsow, Alejandro J. Müller, Aitor Larrañaga and Marcelo Calderón","doi":"10.1039/D3TB01579C","DOIUrl":"https://doi.org/10.1039/D3TB01579C","url":null,"abstract":"<p >Over the last decade, significant progress has been made in developing hydrogels as medical devices. By physically cross-linking pharmaceutically approved polymers into three-dimensional matrices, we can ensure their biocompatibility and facilitate their seamless transition from the laboratory to clinical applications. Moreover, the reversible nature of their physical cross-links allows hydrogels to dissolve in the presence of external stimuli. Particularly, their high degree of hydration, high molecular weight, and superior flexibility of the polymer chains facilitate their interaction with complex biological barriers (<em>e.g.</em>, mucus layer), making them ideal candidates for mucosal drug delivery. However, fine-tuning the composition of the hydrogel formulations is of great importance to optimize the performance of the medical device and its therapeutic cargo. Herein, we investigated the influence of different Eudragits® on the properties of hydrogels based on polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and polyethylene glycol (PEG), which were originally proposed as ocular inserts in previous reports. Our research aims to determine the effects that including different Eudragits® have on the structure and protein ocular delivery ability of various hydrogel formulations. Properties such as matrix stability, protein encapsulation, release kinetics, mucoadhesion, and biocompatibility have been analyzed in detail. Our study represents a guideline of the features that Eudragits® have to exhibit to endow hydrogels with good adhesion to the eye's conjunctiva, biocompatibility, and structural strength to cope with the ocular biointerface and allow sustained protein release. This work has important implications for the design of new hydrogel materials containing Eudragits® in their composition, particularly in mucosal drug delivery.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 9276-9289"},"PeriodicalIF":7.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2023/tb/d3tb01579c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41088169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs†","authors":"Isabel Abánades Lázaro, María Vicent-Morales, Guillermo Mínguez Espallargas and Mónica Giménez-Marqués","doi":"10.1039/D3TB01819A","DOIUrl":"https://doi.org/10.1039/D3TB01819A","url":null,"abstract":"<p >Although Metal–organic frameworks (MOFs) have received attention as drug delivery systems, their application in the delivery of macromolecules is limited by their pore size and opening. Herein, we present the synthesis of nanostructured MUV-2, a hierarchical mesoporous iron-based MOF that can store high payloads of the macromolecular drug paclitaxel (<em>ca.</em> 23% w/w), increasing its selectivity towards HeLa cancer cells over HEK non-cancerous cells. Moreover, this NanoMUV-2 permits full degradation under simulated physiological conditions while maintaining biocompatibility, and is amenable to specific surface modifications that increase its cell permeation, efficient cytosol delivery and cancer-targeting effect, further intensifying the cancer selectivity of paclitaxel.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 9179-9184"},"PeriodicalIF":7.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2023/tb/d3tb01819a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41088161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magneto-assisted enzymatic DNA walkers for simultaneous electrochemical detection of amyloid-beta oligomers and Tau†","authors":"Tao Cheng, Hongxiu Yuan, Yixi Dong, Shuo Xu, Gang Wang, Miaoqing Zhao, Jianwei Jiao and Jin Jiao","doi":"10.1039/D3TB01502E","DOIUrl":"10.1039/D3TB01502E","url":null,"abstract":"<p >DNA walkers have been widely explored and applied as biosensor elements to detect disease-related biomarkers. Traditional interface-anchored DNA walkers typically have a fixed swing arm range and an orientation of the preset track, which might complicate the design of a sensor system and limit its application in more scenes. We propose a simple electrochemical aptasensor to accurately detect Alzheimer's disease (AD) based on a nicking enzyme-powered DNA walker. In this method, bifunctional magnetic nanoparticles are used to identify and capture Aβ oligomers (AβO) and Tau and release the DNA walker. As the DNA walker moves freely on the surface of the electrode, the nicking enzymes circularly cleave and release the two signal substrate chains, significantly amplifying the signal. It has been demonstrated that the constructed sensor can sensitively detect AβO and Tau, and the combined analysis of dual markers improves the accuracy of AD diagnosis. Furthermore, this method can distinguish normal individuals from AD patients in real cerebrospinal fluid samples. The excellent performance of this biosensor makes it promising for clinical applications in diagnosing AD patients and prognosis assessment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 42","pages":" 10088-10096"},"PeriodicalIF":7.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41175687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation","authors":"Meng Fang, Liping Lin, Muyue Zheng, Wei Liu and Rongguang Lin","doi":"10.1039/D3TB01543B","DOIUrl":"10.1039/D3TB01543B","url":null,"abstract":"<p >Bacterial infections and inflammation pose a severe threat to human health and the social economy. The existence of super-bacteria and the increasingly severe phenomenon of antibiotic resistance highlight the development of new antibacterial agents. Due to low cytotoxicity, high biocompatibility, and different antibacterial mechanisms from those for antibiotics, functionalized carbon dots (FCDs) promise a new platform for the treatment of bacterial infectious diseases. However, few articles have systematically sorted out the available antibacterial mechanisms for FCDs and their application in the treatment of bacterial inflammation. This review focuses on the available antibacterial mechanisms for FCDs, including covalent and non-covalent interactions, reactive oxygen species, photothermal therapy, and size effect. Meanwhile, the design of antibacterial FCDs is introduced, including surface modification, doping, and combination with other nanomaterials. Furthermore, this review specifically concentrates on the research advances of antibacterial FCDs in the treatment of bacterial inflammation. Finally, the advantages and challenges of applying FCDs in practical antimicrobial applications are discussed.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 39","pages":" 9386-9403"},"PeriodicalIF":7.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10280438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-atom nanozymes: classification, regulation strategy, and safety concerns","authors":"Jiping Han, Yaohua Gu, Changyi Yang, Lingchen Meng, Runmei Ding, Yifan Wang, Keren Shi and Huiqin Yao","doi":"10.1039/D3TB01644G","DOIUrl":"10.1039/D3TB01644G","url":null,"abstract":"<p >Nanozymes, nanomaterials possessing enzymatic activity, have been studied extensively by researchers. However, their complex composition, low density of active sites, and inadequate substrate selectivity have hindered the maturation and widespread acceptance of nanozymes. Single-atom nanozymes (SAzymes) with atomically dispersed active sites are leading the field of catalysis due to their exceptional performance. The maximum utilization rate of atoms, low cost, well-defined coordination structure, and active sites are the most prominent advantages of SAzymes that researchers favor. This review systematically categorizes SAzymes based on their support type and describes their specific applications. Additionally, we discuss regulation strategies for SAzyme activity and provide a comprehensive summary of biosafety challenges associated with these enzymes.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 41","pages":" 9840-9866"},"PeriodicalIF":7.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectroscopic features of a perylenediimide probe for sensing amyloid fibrils: in vivo imaging of Aβ-aggregates in a Drosophila model organism†","authors":"Nilotpal Barooah, Puja Karmakar, M. K. Sharanya, Monalisa Mishra, Achikanath C. Bhasikuttan and Jyotirmayee Mohanty","doi":"10.1039/D3TB01233F","DOIUrl":"https://doi.org/10.1039/D3TB01233F","url":null,"abstract":"<p >Customised perylenediimide (PDI) chromophores find diverse applications not only as chemosensors, inorganic–organic semiconductors, photovoltaics, photocatalysts, <em>etc.</em>, but also in protein surface engineering, bio-sensors and drug delivery systems. This study focuses on the interaction of a custom synthesized phenylalanine derivatized perylenediimide (<small>L</small>-Phe-PDI) dye with a model protein, insulin, and its structurally distinct fibrils to develop fluorescence sensors for fibrillar aggregates and <em>in vivo</em> imaging applications. Detailed photophysical studies revealed that <small>L</small>-Phe-PDI gets aggregated in the presence of insulin and causes emission quenching at pH 7.4, which in the absence of insulin occurs only at pH ∼2. During <em>in vitro</em> incubation of insulin to its fibrils, the fluorescence intensity of the <small>L</small>-Phe-PDI probe is enhanced to ∼150 fold in a two-stage manner, manifesting the pathways of structural transformation to β-sheet rich mature fibrils. The <em>in vivo</em> sensing has further been validated in living models of the Aβ-mutant <em>Drosophila</em> fly, which is known to develop progressive neurodegeneration comparable to that of human brains with Alzheimer's disease (AD). Bioimaging of the <small>L</small>-Phe-PDI treated Aβ-mutant <em>Drosophila</em> documented the blood–brain/blood–retina-barrier cross-over ability of <small>L</small>-Phe-PDI with no toxic effects. Comparison of the fibrillar images from the brain and eye region with the reference thioflavin T (ThT) probe established the uptake of <small>L</small>-Phe-PDI by the aggregate/fibrillar moieties. The samples from <small>L</small>-Phe-PDI-treated flies apparently displayed reduced fibrillar spots, a possible case of <small>L</small>-Phe-PDI-induced disintegration of fibrillar aggregates at large, an observation substantiated by the improved phenotype activities as compared to the untreated flies. The findings reported both <em>in vitro</em> and <em>in vivo</em> with the <small>L</small>-Phe-PDI material for the first time open up avenues to explore the therapeutic potential of custom-designed PDI derivatives for amyloid fibril sensors and bioimaging.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 39","pages":" 9545-9554"},"PeriodicalIF":7.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41228671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activatable probes with potential for intraoperative tumor-specific fluorescence-imaging guided surgery","authors":"Mingzhu Wu, Deyan Gong, Yuanyuan Zhou, Zhengbao Zha and Xiaoping Xia","doi":"10.1039/D3TB01590D","DOIUrl":"10.1039/D3TB01590D","url":null,"abstract":"<p >Owing to societal development and aging population, the impact of cancer on human health and quality of life has increased. Early detection and surgical treatment are the most effective approaches for most cancer patients. As the scope of conventional tumor resection is determined by auxiliary examination and surgeon experience, there is often insufficient recognition of tiny tumors. The ability to detect such tumors can be improved by using fluorescent tumor-specific probes for surgical navigation. This review mainly describes the design principles and mechanisms of activatable probes for the fluorescence imaging of tumors. This type of probe is nonfluorescent in normal tissue but exhibits obvious fluorescence emission upon encountering tumor-specific substrates, such as enzymes or bioactive molecules, or changes in the microenvironment, such as a low pH. In some cases, a single-factor response does not guarantee the effective fluorescence labeling of tumors. Therefore, two-factor-activatable fluorescence imaging probes that react with two specific factors in tumor cells have also been developed. Compared with single biomarker testing, the simultaneous monitoring of multiple biomarkers may provide additional insight into the role of these substances in cancer development and aid in improving the accuracy of early cancer diagnosis. Research and progress in this field can provide new methods for precision medicine and targeted therapy. The development of new approaches for early diagnosis and treatment can effectively improve the prognosis of cancer patients and help enhance their quality of life.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 41","pages":" 9777-9797"},"PeriodicalIF":7.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: Poly(lactide-co-glycolide) grafted hyaluronic acid-based electrospun fibrous hemostatic fragments as a sustainable anti-infection and immunoregulation material","authors":"Wen Liu, Guanghui Xi, Xiao Yang, Xiao Hao, Mingshan Wang, Yakai Feng, Hao Chen and Changcan Shi","doi":"10.1039/D3TB90162A","DOIUrl":"https://doi.org/10.1039/D3TB90162A","url":null,"abstract":"<p >Expression of concern for ‘Poly(lactide-<em>co</em>-glycolide) grafted hyaluronic acid-based electrospun fibrous hemostatic fragments as a sustainable anti-infection and immunoregulation material’ by Wen Liu <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2019, <strong>7</strong>, 4997–5010, https://doi.org/10.1039/C9TB00659A.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 8821-8821"},"PeriodicalIF":7.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2023/tb/d3tb90162a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24849493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[12]aneN3-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy†","authors":"Xue-Yi Sun, Ya-Xuan Liang, Yi-Nan Gao, Xi Zhang, Rui Liu, Quan Tang, Zhong-Lin Lu and Yang Liu","doi":"10.1039/D3TB01282D","DOIUrl":"https://doi.org/10.1039/D3TB01282D","url":null,"abstract":"<p >A novel dual-responsive nanoparticle (NP) system was aimed to be developed for the co-delivery of camptothecin (CPT) and plasmid encoding TNF-related apoptosis-inducing ligand (pTRAIL) DNA in cancer therapy. The combination of the prodrug CPT and the nucleic acid condensing di-(triazole-[12]aneN3) unit with 4-nitrobenzyl ester through alkyl chains resulted in three nitroreductase (NTR) responsive amphiphiles, <strong>CNN1–CNN3</strong> (with 5, 8, and 11 carbon chains, respectively). Among them, <strong>CNN2</strong> was the most effective in inhibiting the proliferation of HeLa cells in the presence of fusogenic lipid DOPE. The NPs composed of <strong>CNN2</strong>, pDNA, and DOPE were further co-assembled with ROS-responsive thioketal-linked amphiphilic polymer (<strong>TTP</strong>) to afford the core–shell NPs (<strong>CNN2-DT</strong>/pDNA) with an average size of 118 nm, which exhibited high drug-loading capacity, excellent serum tolerance, and good biocompatibility. In the presence of ROS, NTR, and NADH, the core–shell NPs were decomposed, leading to the efficient release of 80% CPT and abundant pDNA. The self-assembly and delivery process of <strong>CNN2-DT</strong> NPs and DNA were clearly observed through the AIE fluorescent imaging. <em>In vitro</em> and <em>in vivo</em> results demonstrated that the <strong>CNN2-DT</strong>/pTRAIL NPs synergistically promoted 68% apoptosis of tumor cells and inhibited tumor growth with negligible toxic side effects. This study showed that the combination of prodrug and nucleic acid through dual-responsive core–shell NPs provide a spatially and temporally-controlled strategy for cancer therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 8943-8955"},"PeriodicalIF":7.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41082604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring release mechanisms by disrupting π–π stacking regions in stable micelles†","authors":"Fusheng Zhang, Gongcui Pei, Baihao Huang, Jianchang Xu and Lijuan Zhang","doi":"10.1039/D3TB01388J","DOIUrl":"https://doi.org/10.1039/D3TB01388J","url":null,"abstract":"<p >π–π stacking strategies can enhance the stability performance of delivery platforms but are often restricted by incomplete drug release performance, even with the help of crosslinking strategies. Therefore, there has been considerable interest in enhancing the drug release performance by disrupting the π–π stacking region (structural rearrangements). Herein, we synthesized poly(3-(isobutyloxy)-2-oxopropyl benzoate)-<em>b</em>-poly(2-hydroxybutyl methacrylate)-<em>co</em>-poly((ethylene glycol)methylether methacrylate) [PBOOPMA-<em>b</em>-P(HBMA-<em>co</em>-PEGMA), PHB] and revealed the drug release mechanism of PHB-based micelles. The structural rearrangements derived from the crosslinking strategy were revealed to improve the early release performance by 43–55% using micellar dissolutions. Moreover, the esterase-responsive strategy was elucidated to induce reassembly with 77–79% size variation, intensifying the structural rearrangements, which was also synergistic with the crosslinking strategy. Based on the advantages of improving drug release performance, the esterase-responsive strategy was considered a promising candidate for enhancing late release performance. Meanwhile, it is believed that such responsive modulation (crosslinking, esterase-responsive) in the π–π stacking region will become highly promising for subsequent research. Finally, the biosafety of 95.81% at 400 mg L<small>⁻¹</small> and drug cytotoxicity of IC<small>₅₀</small> ≈ 2.5 mg L<small>⁻¹</small> of PHB-EDE@CPT were also validated, confirming the broad application prospects of PHB-based crosslinked micelles.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 9246-9259"},"PeriodicalIF":7.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41088167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}