Journal of Materials Chemistry B最新文献

{"title":"Sugar-coated immunometabolism: functionalized biomaterials as metabolic regulators of immune responses","authors":"Francesca Taraballi and Bruna Corradetti","doi":"10.1039/D6TB00355A","DOIUrl":"10.1039/D6TB00355A","url":null,"abstract":"<p >Immunometabolism, the intersection of immune function and cellular metabolism, has emerged as a powerful lens for understanding and directing host response to biomaterials. Upon implantation, biomaterials often provoke immune activation, potentially leading to chronic inflammation, fibrotic encapsulation, and impaired integration. Recent advances point to sugar functionalization as a promising strategy to steer immunometabolic pathways, enhance biocompatibility, and promote regenerative outcomes. Naturally derived monosaccharides (<em>e.g.</em>, mannose, glucose, galactose), polysaccharides (<em>e.g.</em>, dextran, chitosan), and glycosaminoglycans (<em>e.g.</em>, hyaluronic acid, heparin) engage distinct immune receptors to induce targeted metabolic reprogramming in macrophages, dendritic cells, and other innate effectors. This minireview synthesizes recent breakthroughs in the field, elucidating how distinct sugar classes reshape immunometabolism by modulating glycolysis, oxidative phosphorylation, fatty acid metabolism, and associated inflammatory pathways and highlighting their translational applications in precision medicine. We discuss design considerations for sugar-functionalized scaffolds and outline future directions centered on precision glycoengineering, integrated metabolic analyses, and personalized therapeutic platforms.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 21","pages":" 6480-6493"},"PeriodicalIF":6.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of 2′-fluoro nucleobase modifications on CD detection, sensitivity and specificity of short oligonucleotides bound to alginate hydrogels","authors":"Daisee K. Lubrin, Colin I. Elliott, Jean-Paul Desaulniers and Theresa Stotesbury","doi":"10.1039/D5TB02880A","DOIUrl":"10.1039/D5TB02880A","url":null,"abstract":"<p >Chemical modification of oligonucleotides has aided in the advancement of various therapeutic applications; however, their impact on biosensor performance remains understudied. As demand grows for rapid, sensitive, and portable detection technologies in healthcare, environmental, and forensic fields, leveraging the effects of chemical modifications with spectroscopic detection methods offers an opportunity to improve biosensor performance. Herein, we synthesize label-free oligonucleotide-bound alginate hydrogels as biosensors and use circular dichroism (CD) spectroscopy to detect and confirm DNA and RNA hybridization without amplification or labelling. We particularly focus on the impact of 2′-fluoro modifications on biosensor sensitivity and specificity. Fluorine-modified DNA-based biosensors demonstrate more than a threefold increase in sensitivity compared to unmodified DNA. RNA-based biosensors displayed a similar trend, where 2′-fluoro nucleobase modifications significantly lowered the LOD. Biosensor specificity is evaluated by adding mixtures containing up to four non-complementary strands to the alginate-oligo hydrogels. Fluorine-modified biosensors consistently demonstrated greater specificity with more distinct shifts in CD spectra compared to unmodified DNA. Principal component analysis was applied to differentiated samples with and without a bound complement. Additionally, when thermal melt data was combined with CD spectral data it was possible with a random forest model to predict whether unknown samples demonstrated complement binding, with accuracies of 95% and 83% for 2′-F modified and unmodified oligos, respectively. Our findings highlight the enhancement in biosensor sensitivity and specificity conferred by 2′-fluoro modifications, demonstrating their potential for improved label-free, amplification-free detection of oligonucleotides in complex environmental and forensic samples.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 6050-6064"},"PeriodicalIF":6.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/tb/d5tb02880a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substrate-directed zinc phosphate nanodeposition for durable dentin bonding: one-step interfacial dehydration and proteolysis resistance","authors":"Yifan Chen, Yajie Cheng, Yadong Chen, Mengqi Pan, Yanji Lu, Xue Yang, Qi Zhong, Honghai Yan, Qiaojie Luo, Chang Shu, Wei Yao and Xiaodong Li","doi":"10.1039/D6TB00339G","DOIUrl":"10.1039/D6TB00339G","url":null,"abstract":"<p >Achieving durable bonding at hydrated polymer–collagen biointerfaces remains challenging because water trapped at the interface and matrix metalloproteinase (MMP)-driven collagen degradation undermine adhesion over time. Using dentin as a clinically relevant collagen scaffold, we introduce a single-step, substrate-directed pretreatment that rapidly drives <em>in situ</em> nanodeposition of zinc phosphate nanoparticles (nano-ZnPs) along collagen fibrils. This approach simultaneously modulates interfacial hydration, adhesive infiltration, and proteolytic activity. A kinetically unstable ZnSO<small>₄</small>/K<small>₂</small>HPO<small>₄</small> precursor was applied to demineralized dentin to promote site-selective capture, nucleation, and fibril-conformal growth of nano-ZnPs. Interfacial hydration and adhesive infiltration were quantified, gelatinolytic activity was characterized under exogenous and endogenous challenges, and bonding performance was evaluated using microtensile bond strength (µTBS) and nanoleakage, with durability assessed after 10 000 thermal cycles. Cytocompatibility was also examined. Nano-ZnPs preferentially deposited within polar/anionic collagen domains as amorphous 5–20 nm particles, reduced interface-confined water, and facilitated deeper infiltration of hydrophobic monomers, while a zinc-enriched interface exhibited markedly attenuated proteolytic activity under both exogenous and endogenous challenges. Compared with controls, a 30 s pretreatment increased µTBS by 21–32% and reduced nanoleakage by 66–78%. Interfacial integrity was maintained after thermal aging, and no detectable cytotoxicity was observed. These results establish kinetically programmed, collagen-guided nanodeposition as a workflow-compatible strategy for strengthening resin–dentin interfaces without altering adhesive formulations or curing protocols.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 20","pages":" 6270-6281"},"PeriodicalIF":6.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embedding near-infrared fluorescent single-walled carbon nanotubes within freeform fabricated hydrogels via continuous digital light processing","authors":"Alexander Boltinhouse, S M Abu Naser Shovon, Saroj Subedi, Hussain Kawsar Chowdhury, Henry Oliver Tenadooah Ware and Januka Budhathoki-Uprety","doi":"10.1039/D6TB00108D","DOIUrl":"10.1039/D6TB00108D","url":null,"abstract":"<p >Photoluminescent single-walled carbon nanotubes (SWCNTs) are emerging materials for developing bioimaging agents and sensors. Free-standing architectures which include 3D printed freeform hydrogels can be leveraged as versatile platforms for sensors. However, a key challenge in developing 3D-printed SWCNT-based optical probes and sensors is preserving their optical properties under demanding processing conditions, such as UV irradiation and <em>in situ</em> free radical polymerization used in 3D printing processes. This research leveraged a continuous digital light processing (CDLP) technique to fabricate fluorescent SWCNT-embedded freeform hydrogels. We found that integrating an aqueous suspension of SWCNTs did not inhibit the creation of 3D fabricated hydrogel objects. However, the photoluminescence of SWCNTs in 3D-printed objects was adversely impacted by the SWCNT functionalization type, hydrogel ink formulations, and the process parameters during CDLP. Upon screening the formulation and the CDLP conditions, we identified that SWCNTs non-covalently functionalized with poly(styrene-<em>co</em>-styrene sulfonate) (PS-<em>co</em>-PSS) maintained their characteristic NIR emission in the 3D printing ink formulation and upon exposure to the UV-curing process. More importantly, no apparent leaching of SWCNTs was observed after two weeks of soaking in deionized water. By tuning the hydrogel ink formulation, structures with desirable application-specific properties could be achieved, such as the hydrogel 9–70 composition (9 wt% crosslinker-to-monomer ratio and 70 wt% water) exhibiting stretchability increase of up to ∼142%. Both the hydrated and the dehydrated samples of key hydrogel ink formulations showed no evidence of cracking after 24 hours. This successful integration of NIR fluorescent SWCNTs into complex, freeform hydrogel architectures <em>via</em> CDLP represents a fundamental advance toward creating robust, portable, and versatile optical sensing platforms.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5960-5972"},"PeriodicalIF":6.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/tb/d6tb00108d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coordination-driven self-assembled nanozyme-loaded GelMA microneedles for enhanced photodynamic therapy of diabetic infected wounds","authors":"Lisha Jiang, Jiaqiao Liang, Tianyue Wu, Jianyang Shi, Chenggong Hu and Haibo Wang","doi":"10.1039/D6TB00649C","DOIUrl":"10.1039/D6TB00649C","url":null,"abstract":"<p >Infected diabetic wounds, particularly those complicated by multidrug-resistant bacteria, pose a significant clinical challenge due to the limited efficacy of conventional debridement and antibiotic therapies. Photodynamic therapy (PDT) has emerged as a promising antimicrobial strategy. However, its therapeutic potential is severely hampered by the hypoxic microenvironment of diabetic wounds. This study aimed to develop a multifunctional nanozyme integrated microneedle system, termed GM@MnFC, within a therapeutic framework that combines material design, delivery strategy, and microenvironment modulation. MnFC nanoparticles were constructed through coordination driven self assembly of Fmoc-<small>L</small>-leucine, Mn<small>²⁺</small>, and the photosensitizer chlorin e6 (Ce6). The incorporated Mn<small>²⁺</small> endowed the nanoparticles with intrinsic catalase-like activity. This enabled <em>in situ</em> oxygen generation from pathological hydrogen peroxide accumulated in diabetic wounds, thereby overcoming the oxygen dependency of PDT. Loading MnFC into dissolving gelatin methacryloyl (GelMA) microneedles achieved efficient deep tissue delivery to target bacteria residing in dermal layers. <em>In vitro</em> studies demonstrated that MnFC possessed excellent catalase-like activity and efficient singlet oxygen generation under 660-nm laser irradiation, exhibiting potent antibacterial efficacy against both <em>Escherichia coli</em> (<em>E. coli</em>) and methicillin-resistant <em>Staphylococcus aureus</em> (MRSA). GM@MnFC microneedle treatment significantly accelerated wound closure, enhanced re-epithelialization and collagen deposition, and favorably regulated inflammatory cytokine expression in a diabetic rat model of MRSA-infected wounds. Biosafety evaluations confirmed the excellent biocompatibility of this system. This study presents an innovative strategy exploiting pathological by-products of diabetic wounds to fuel antimicrobial therapy, thereby providing valuable insights for designing multifunctional nanomedicine platforms for chronic wound management.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 20","pages":" 6221-6236"},"PeriodicalIF":6.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced in vitro photodynamic performance under hypoxia-related conditions by BP–Au@MnO2–Ce6 nanocomposites","authors":"Yingli Ma, Ling Qi, Xiaoya Ma, Mayifei Rong, Liying Lu, Wei Yuan and Xiaoguang Xu","doi":"10.1039/D6TB00379F","DOIUrl":"10.1039/D6TB00379F","url":null,"abstract":"<p >Photodynamic therapy (PDT) is a widely used therapeutic strategy that kills tumor cells through singlet oxygen (<small>¹</small>O<small>₂</small>) generated by the combined action of a photosensitizer, oxygen, and light irradiation. However, the efficacy of PDT is often limited by hypoxia, elevated glutathione (GSH) levels in solid tumors, and the hydrophobicity of photosensitizers. Herein, BP–Au@MnO<small>₂</small>–Ce6 nanocomposites based on black phosphorus nanosheets (BPNS) were constructed to enhance photodynamic performance under hypoxia-related conditions <em>in vitro</em>. In the nanocomposites, BPNS serve as both a photosensitive component and a structural platform for the assembly of Au nanoparticles and Ce6 after PEI modification, thereby enhancing light utilization during PDT. MnO<small>₂</small> can catalyze the decomposition of endogenous H<small>₂</small>O<small>₂</small> to generate oxygen and can also consume GSH, thereby supporting singlet oxygen generation and reducing the intracellular antioxidant scavenging capacity. The experimental results indicate that the BP–Au@MnO<small>₂</small>–Ce6 nanocomposites enable oxygen generation, GSH depletion, and enhanced <small>¹</small>O<small>₂</small> generation. Moreover, the nanocomposites exhibit good biocompatibility and inhibit tumor cell growth <em>in vitro</em> under both normoxic and hypoxic conditions, highlighting their potential as a multifunctional platform for hypoxia-related photodynamic enhancement.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 21","pages":" 6559-6566"},"PeriodicalIF":6.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the optical characteristics of pseudo-resonance and non-pseudo-resonance structures","authors":"Xinliang Guo, Wei He, Yufei Wang, Yuhang Wang, Wutong Du, Ryan Tsz Kin Kwok, Hongyan Liu, Ben Zhong Tang and Huajie Zhu","doi":"10.1039/D6TB00673F","DOIUrl":"10.1039/D6TB00673F","url":null,"abstract":"<p >Five pairs of pseudo-resonance structures, which have two sets of physical data, such as two sets of NMR spectra in solution, and non-pseudo-resonance structures were synthesized under mild conditions. Among these, two of the pseudo-resonance structures exhibited either stronger aggregation-induced emission (AIE) brightness or distinct emission colors compared to their corresponding non-pseudo-resonance analogues. Furthermore, one AIE pseudo-resonance structure demonstrated lower toxicity and faster cell membrane penetration than its non-pseudo-resonance counterpart and exhibited high efficiency in endoplasmic reticulum (ER) imaging. This new approach may hold potential for further development in biological imaging and molecular diagnostics.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5902-5912"},"PeriodicalIF":6.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired antimicrobial glass coatings for clear and infection-resistant surfaces","authors":"Subhankar Maity, Arup Sarkar, Arindam Patra, Joy Mitra and Jayanta Haldar","doi":"10.1039/D6TB00465B","DOIUrl":"10.1039/D6TB00465B","url":null,"abstract":"<p >Optically transparent glass surfaces that simultaneously prevent fogging, resist contamination, and eliminate microbial growth are highly desirable for medical optics, protective equipment, and advanced architectural applications. In applications where sustained visual clarity and resistance to microbial colonization are critical for diagnostic accuracy and patient safety, as well as in self-cleaning glass panels that reduce water consumption and reliance on chemical surfactants, multifunctional surface coatings are highly desirable. Here, we report a mussel-inspired, single-step dip-coating strategy for covalent immobilization of a dopamine-conjugated quaternary antimicrobial polymer (DQP<small>_Pr</small>) onto glass substrates, providing a robust, scalable route to multifunctional surface engineering. Atomic force microscopy (AFM) reveals uniform nanoscale coatings, with superhydrophilicity in the Wenzel wetting regime. The modified surfaces exhibit pronounced superhydrophilicity (contact angle of ∼3–4°) while maintaining high visible transparency, enabling effective antifogging performance. The coatings further demonstrate self-cleaning behaviour by efficiently removing hydrophobic particulates upon simple water rinsing. Importantly, above a threshold coating concentration, the surfaces display potent antimicrobial activity against Gram-positive and Gram-negative bacteria as well as drug-resistant fungal strains. The coatings retain structural integrity and functional performance after repeated washing cycles and across varying temperature conditions, underscoring their durability and strong potential for practical biomedical and protective applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 20","pages":" 6364-6376"},"PeriodicalIF":6.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An antibacterial gradient-pore artificial skin with high exudate-absorption and hemostatic properties","authors":"Dongxiao Ren, Wenxi Zhu, Sai Yan, Shuang Wu, Xunda Feng, Ran Cao and Meifang Zhu","doi":"10.1039/D6TB00023A","DOIUrl":"10.1039/D6TB00023A","url":null,"abstract":"<p >Wounds frequently produce excessive exudation and are highly susceptible to bacterial contamination, posing significant challenges for effective wound management. To address these issues, we prepared a gradient-pore artificial skin capable of high-capacity exudate absorption while providing robust antibacterial and hemostatic functions. Using natural polymer materials (gelatin, chitosan) as raw materials, with protocatechualdehyde, sodium hydroxide, and Ga<small>³⁺</small> as crosslinking agents, double crosslinked hydrogels were prepared. Then, a three-layer artificial skin with gradient porosity was fabricated by sequential assembly of the hydrogel layers followed by freeze-drying. The artificial skin has excellent degradability, strong antibacterial activity (97% inhibition rate), high liquid absorption (∼8000% swelling rate within 72 hours), and favorable moisturizing properties (80%). The artificial skin demonstrates superior hemostatic performance, achieving minimal blood loss and a rapid clotting time of 67.64 s. When applied to wounds, it can coordinate and regulate inflammation resolution, fibroblast proliferation, and extracellular matrix deposition in the wound. This multilayer design, inspired by natural skin architecture, enables functional tissue regeneration and offers a promising strategy for advanced wound dressings.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5913-5923"},"PeriodicalIF":6.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjugating M13 bacteriophage targeting folate receptor alpha with multiple photosensitizers: a flexible phototheranostic platform against ovarian cancer","authors":"Alena Kaltenbrunner, Andrea Martino, Michela Nigro, Andrea Carboni, Alessia Marconi, Nicolò Mercorelli, Manuele Di Sante, Chiara Di Donato, Annapaola Petrosino, Simona Corrà, Monica De Luise, Giuseppe Gasparre, Matteo Calvaresi, Alberto Danielli, Paolo Emidio Costantini and Matteo Di Giosia","doi":"10.1039/D5TB02844B","DOIUrl":"10.1039/D5TB02844B","url":null,"abstract":"<p >Ovarian cancer remains one of the deadliest malignancies in women, largely due to late-stage diagnosis and limited efficacy of current chemotherapies. To address this challenge, we introduce an advanced phage-based phototheranostic platform that leverages genetic programmability and modular chemical functionalization for selective tumor eradication. We first generated a single-chain variable fragment derived from the anti-folate receptor α (FRα) antibody MORAb-003, then we engineered M13 bacteriophage displaying this targeting moiety, enabling high-affinity recognition of FRα-overexpressing ovarian cancer cells. Using orthogonal bioconjugation, we then conjugated multiple copies of two complementary photosensitizers, chlorin e6 (Ce6) and rose bengal (RB), onto the phage capsid, yielding a photoresponsive nanoconstruct with dual excitation/emission profiles. This multifunctional viral scaffold seamlessly integrates tumor targeting, fluorescence imaging, and light-activated cytotoxicity into a single biocompatible architecture. The resulting M13<small>_FRα</small>–Ce6–RB conjugates exhibit potent photodynamic activity under both red and green light irradiation, highlighting the potential of refactored M13 phages as flexible nanocarriers for precision phototherapy. This work presents a customizable and translationally relevant nanoplatform for image-guided treatment of chemoresistant ovarian cancer and other FRα-positive malignancies.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 23","pages":" 7164-7178"},"PeriodicalIF":6.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/tb/d5tb02844b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}