Journal of Materials Chemistry B最新文献_第10页

Intravascular elimination of circulating tumor cells and cascaded embolization with multifunctional 3D tubular scaffolds† 利用多功能三维管状支架在血管内消除循环肿瘤细胞并进行级联栓塞。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-08-01 DOI: 10.1039/D4TB01151A

Yijing Chen, Cuiwen Li, Jinghui Yang, Ming Wang, Yike Wang, Shibo Cheng, Weihua Huang, Guohua Yuan and Min Xie

{"title":"Intravascular elimination of circulating tumor cells and cascaded embolization with multifunctional 3D tubular scaffolds†","authors":"Yijing Chen, Cuiwen Li, Jinghui Yang, Ming Wang, Yike Wang, Shibo Cheng, Weihua Huang, Guohua Yuan and Min Xie","doi":"10.1039/D4TB01151A","DOIUrl":"10.1039/D4TB01151A","url":null,"abstract":"The primary tumor (“root”) and circulating tumor cells (CTCs; “seeds”) are vital factors in tumor progression. However, current treatment strategies mainly focus on inhibiting the tumor while ignoring CTCs, resulting in tumor metastasis. Here, we design a multifunctional 3D scaffold with interconnected macropores, excellent photothermal ability and perfect bioaffinity as a blood vessel implantable device. When implanted upstream of the primary tumor, the scaffold intercepts CTCs fleeing back to the primary tumor and then forms “micro-thrombi” to block the supply of nutrients and oxygen to the tumor for embolization therapy. The scaffold implanted downstream of the tumor efficiently captures and photothermally kills the CTCs that escape from the tumor, thereby preventing metastasis. Experiments using rabbits demonstrated excellent biosafety of this scaffold with 86% of the CTC scavenging rate, 99% of the tumor inhibition rate and 100% of CTC killing efficiency. The multifunctional 3D scaffold synergistically inhibits the “root” and eliminates the “seeds” of the tumor, demonstrating its potential for localized cancer therapy with few side effects and high antitumor efficacy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steric protection of near-infrared fluorescent dyes for enhanced bioimaging 用于增强生物成像的近红外荧光染料的立体保护。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-31 DOI: 10.1039/D4TB01281J

Sai Shradha Reddy Kommidi, Kirk M. Atkinson and Bradley D. Smith

{"title":"Steric protection of near-infrared fluorescent dyes for enhanced bioimaging","authors":"Sai Shradha Reddy Kommidi, Kirk M. Atkinson and Bradley D. Smith","doi":"10.1039/D4TB01281J","DOIUrl":"10.1039/D4TB01281J","url":null,"abstract":"Near-fluorescent (NIR) dyes that absorb and emit light in the wavelength range of 650–1700 nm are well-suited for bioimaging due to the improved image contrast and increased penetration of the long-wavelength light through biological tissue. However, the imaging performance of NIR fluorescent dyes is limited by several inherent photophysical and physicochemical properties including, low fluorescence quantum yield, high chemical and photochemical reactivity, propensity to self-aggregate in water, non-specific association with off-target biological sites, and non-optimal pharmacokinetic profiles in living subjects. In principle, all these drawbacks can be alleviated by steric protection which is a structural process that surrounds the fluorophore with bulky groups that block undesired intermolecular interactions. The literature methods to sterically protect a long-wavelength dye can be separated into two general strategies, non-covalent dye encapsulation and covalent steric appendage. Illustrative examples of each method show how steric protection improves bioimaging performance by providing: (a) increased fluorescence brightness, (b) higher fluorophore ground state stability, (c) decreased photobleaching, and (d) superior pharmacokinetic profile. Some sterically protected dyes are commercially available and further success with future systems will require experts in chemistry, microscopy, cell biology, medical imaging, and clinical medicine to work closely as interdisciplinary teams.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb01281j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grafting and controlled release of antimicrobial peptides from mesoporous silica† 介孔二氧化硅中抗菌肽的接枝和控释。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-30 DOI: 10.1039/D4TB00752B

Mohadeseh Bagherabadi, Marie Fleckenstein, Oleksandr Moskalyk, Andrea Belluati, Olga Avrutina and Annette Andrieu-Brunsen

{"title":"Grafting and controlled release of antimicrobial peptides from mesoporous silica†","authors":"Mohadeseh Bagherabadi, Marie Fleckenstein, Oleksandr Moskalyk, Andrea Belluati, Olga Avrutina and Annette Andrieu-Brunsen","doi":"10.1039/D4TB00752B","DOIUrl":"10.1039/D4TB00752B","url":null,"abstract":"The grafting of antimicrobial peptides onto mesoporous silica particles and their controlled release using a green light-responsive linker, which enables tunable release-concentration-time profiles, is presented. The mesoporous silica surface is functionalized with antimicrobial peptides employing sequential functionalization steps, including the grafting of 3-[(2-propynylcarbamate)propyl]triethoxysilane (PPTEOS) as anchor, boron-dipyrromethene (BODIPY) as photosensitive linker, and C14R peptides as antimicrobial agents. Characterization using scanning electron microscopy (SEM), transmission electron microscopy (TEM), attenuated total reflectance infrared (ATR-IR) spectroscopy, and thermogravimetric analysis (TGA) validate the successful fabrication and functionalization of mesoporous silica. The ester-1,2,3-triazole-BODIPY demonstrates high sensitivity to green light and enables C14R antimicrobial peptide release with adjusted concentration-time profiles. Under the applied conditions up to 64 μg mL−1 were released within 40 minutes. The antimicrobial activity of the released C14R on Escherichia coli. BL21(DE3) is demonstrated. Overall, the use of the photosensitive linker not only provides a promising avenue for controlling the release of biomolecules and therapeutics but also opens up opportunities for the development of materials for targeted release in wound dressings, for example.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable, aqueous exfoliation of MoS2via bio-inspired avenues† 通过生物启发途径实现 MoS2 的可持续水性剥离。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-30 DOI: 10.1039/D4TB01127A

Le Nhan Pham, Yuliana Perdomo, Joseph M. Slocik, Rahul Rao, Tiffany R. Walsh and Marc R. Knecht

{"title":"Sustainable, aqueous exfoliation of MoS2via bio-inspired avenues†","authors":"Le Nhan Pham, Yuliana Perdomo, Joseph M. Slocik, Rahul Rao, Tiffany R. Walsh and Marc R. Knecht","doi":"10.1039/D4TB01127A","DOIUrl":"10.1039/D4TB01127A","url":null,"abstract":"Two dimensional (2D) nanosheets of MoS2 were succesfully produced by an exfoliation process in aqueous media with the support from peptides and sonication. The exfoliation process assisted by uncapped MoSBP1 peptides was found to have enhanced efficiency in comparison to the capped counterpart. MoS2 nanosheets obtained using uncapped MoSBP1 have thinner structures containing one layer of MoS2, while in capped version of peptides, MoS2 nanosheets tend to form multilayer (up to 4) structures of exfoliated sheets. Molecular dynamics simulations indicate that inter-sheet gaps generated by sonication in MoS2 nanostacks cannot be maintained by water only; the gaps closed after ∼11 ns. Both capped CMoSBP1 and uncapped MoSBP1 were seen to spontaneously insert into the gap in nanostacks of MoS2 and they can ultimately maintain the inter-sheet gap for longer (≥20 ns). Potential of mean force profiles for the association of two MoS2 nanosheets decorated with CMoSBP1 and MoSBP1 versions of peptides revealed that uncapped MoSBP1 peptides provide good protection from MoS2 nanosheet re-unification. Such protection can prevent the nanosheets from reassociation and subsequent aggregation, whereas the capped CMoSBP1 peptides can offer protection, but over a shorter range. These simulation results could explain the experimental observation of greater efficiency of exfoliation in uncapped MoSBP1 peptides.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb01127a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable and implantable biosensors: mechanisms and applications in closed-loop therapeutic systems 可穿戴和植入式生物传感器：闭环治疗系统的机制和应用。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-30 DOI: 10.1039/D4TB00782D

Zeyuan Zheng, Runjin Zhu, Ian Peng, Zitong Xu and Yuanwen Jiang

{"title":"Wearable and implantable biosensors: mechanisms and applications in closed-loop therapeutic systems","authors":"Zeyuan Zheng, Runjin Zhu, Ian Peng, Zitong Xu and Yuanwen Jiang","doi":"10.1039/D4TB00782D","DOIUrl":"10.1039/D4TB00782D","url":null,"abstract":"This review article examines the current state of wearable and implantable biosensors, offering an overview of their biosensing mechanisms and applications. We also delve into integrating these biosensors with therapeutic systems, discussing their operational principles and incorporation into closed-loop devices. Biosensing strategies are broadly categorized into chemical sensing for biomarker detection, physical sensing for monitoring physiological conditions such as pressure and temperature, and electrophysiological sensing for capturing bioelectrical activities. The discussion extends to recent developments in drug delivery and electrical stimulation devices to highlight their significant role in closed-loop therapy. By integrating with therapeutic devices, biosensors enable the modulation of treatment regimens based on real-time physiological data. This capability enhances the patient-specificity of medical interventions, an essential aspect of personalized healthcare. Recent innovations in integrating biosensors and therapeutic devices have led to the introduction of closed-loop wearable and implantable systems capable of achieving previously unattainable therapeutic outcomes. These technologies represent a significant leap towards dynamic, adaptive therapies that respond in real-time to patients' physiological states, offering a level of accuracy and effectiveness that is particularly beneficial for managing chronic conditions. This review also addresses the challenges associated with biosensor technologies. We also explore the prospects of these technologies to address their potential to transform disease management with more targeted and personalized treatment solutions.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb00782d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proximity labeling expansion microscopy (PL-ExM) evaluates interactome labeling techniques† 近距离标记扩展显微镜（PL-ExM）评估了交互组标记技术。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-30 DOI: 10.1039/D4TB00516C

Sohyeon Park, Xiaorong Wang, Yajin Mo, Sicheng Zhang, Xiangpeng Li, Katie C. Fong, Clinton Yu, Arthur A. Tran, Lorenzo Scipioni, Zhipeng Dai, Xiao Huang, Lan Huang and Xiaoyu Shi

{"title":"Proximity labeling expansion microscopy (PL-ExM) evaluates interactome labeling techniques†","authors":"Sohyeon Park, Xiaorong Wang, Yajin Mo, Sicheng Zhang, Xiangpeng Li, Katie C. Fong, Clinton Yu, Arthur A. Tran, Lorenzo Scipioni, Zhipeng Dai, Xiao Huang, Lan Huang and Xiaoyu Shi","doi":"10.1039/D4TB00516C","DOIUrl":"10.1039/D4TB00516C","url":null,"abstract":"Understanding protein–protein interactions (PPIs) through proximity labeling has revolutionized our comprehension of cellular mechanisms and pathology. Various proximity labeling techniques, such as HRP, APEX, BioID, TurboID, and μMap, have been widely used to biotinylate PPIs or organelles for proteomic profiling. However, the variability in labeling precision and efficiency of these techniques often results in limited reproducibility in proteomic detection. We address this persistent challenge by introducing proximity labeling expansion microscopy (PL-ExM), a super-resolution imaging technique that combines expansion microscopy with proximity labeling techniques. PL-ExM enabled up to 17 nm resolution with microscopes widely available, providing visual comparison of the labeling precision, efficiency, and false positives of different proximity labeling methods. Our mass spectrometry proteomic results confirmed that PL-ExM imaging is reliable in guiding the selection of proximity labeling techniques and interpreting the proteomic results with new spatial information.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on biodegradable magnesium phosphate ceramics in orthopaedic applications 可生物降解磷酸镁陶瓷在骨科应用方面的研究进展。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-30 DOI: 10.1039/D4TB01123F

Kaushik Sarkar

{"title":"Research progress on biodegradable magnesium phosphate ceramics in orthopaedic applications","authors":"Kaushik Sarkar","doi":"10.1039/D4TB01123F","DOIUrl":"10.1039/D4TB01123F","url":null,"abstract":"To overcome critical size bone defects, calcium phosphate (CaP)-based ceramics have been widely explored. The compositional similarity with bone matrix and degradability are the main reasons for their selection in orthopaedic biomaterials. However, the low solubility rate under in vivo conditions raises concerns about these CaP groups, particularly hydroxyapatite (HA) and tricalcium phosphate (TCP) ceramics. Therefore, reliable and suitable degradable ceramics for bone defect repair are always an important research direction for researchers. The magnesium phosphate (MgP) group of bioceramics has been studied for orthopaedic applications and is comparatively new compared to traditional CaP ceramics. The role of magnesium in different biochemical processes, such as DNA stabilization, bone density maintenance, regulating Ca and Na ion channels, and cell proliferation and differentiation enhancement, is a key parameter for the development of MgP bioceramics. This article aims to give a comprehensive review of MgP ceramics in bone tissue engineering. Here, we have highlighted several preparation techniques, the existence of porosity, and the impact of metal ion doping on MgP bioceramics. Finally, in vitro and in vivo responses of MgP bioceramics in bone formation are discussed.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation† 可喷涂的氧化聚乙烯醇具有更好的降解性和足够的机械性能，可用于水果保鲜。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-30 DOI: 10.1039/D4TB00896K

Yi Lu, Guoming Liu, Kaixin Zhang, Ziyi Wang, Peijie Xiao, Changhua Liu, Longying Deng, Fenglu Li, Gaoxing Pan, Shuxian He, Jiefeng Gao and Jin Zhang

{"title":"Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation†","authors":"Yi Lu, Guoming Liu, Kaixin Zhang, Ziyi Wang, Peijie Xiao, Changhua Liu, Longying Deng, Fenglu Li, Gaoxing Pan, Shuxian He, Jiefeng Gao and Jin Zhang","doi":"10.1039/D4TB00896K","DOIUrl":"10.1039/D4TB00896K","url":null,"abstract":"Besides their limited preservation capacity and low biosafety, traditional fruit preservation procedures exacerbate “white pollution” because they utilize excessive plastic. Herein, an environmentally friendly one-pot method was developed to obtain degradable polyvinyl alcohol (PVA), where the hydroxyl radicals generated through the reaction between hydrogen peroxide (H2O2) and iron ions functioned to oxidize PVA. The oxidized PVA (OPVA-1.0) with abundant ketone groups, reduced crystallinity, and short molecular chains was completely degraded into H2O and CO2 after being buried in the soil for ∼60 days. An improvement in its degradation rate did not weaken the mechanical properties of OPVA-1.0 compared to other modified PVA films because the adverse effect of decreased crystallinity on its mechanical performance was offset by its ion coordination. Alternatively, the tensile strength or toughness of OPVA-1.0 was enhanced due to its internal multi-level interactions including molecular chain entanglement, hydrogen bonding, and metal coordination bonds. More interestingly, OPVA-1.0 was water-welded into various products in a recyclable way owing to its reversible physical bonds, where it was sprayed, dipped, or brushed conformally onto different perishable fruits to delay their ripening by 5–14 days. Based on the cellular biocompatibility and biosafety evaluations in mice, OPVA-1.0 obtained by the facile oxidation strategy was demonstrated to alleviate “white pollution” and delay the ripening of fruits effectively.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable conductive hydrogel electrodes for minimally invasive neural interfaces† 用于微创神经接口的可注射导电水凝胶电极。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-30 DOI: 10.1039/D4TB00679H

Ines Kusen, Aaron Lee, Estelle A. Cuttaz, Zachary K. Bailey, Joshua Killilea, Shirine Merlo-Nikpay Aslie, Josef A. Goding and Rylie A. Green

{"title":"Injectable conductive hydrogel electrodes for minimally invasive neural interfaces†","authors":"Ines Kusen, Aaron Lee, Estelle A. Cuttaz, Zachary K. Bailey, Joshua Killilea, Shirine Merlo-Nikpay Aslie, Josef A. Goding and Rylie A. Green","doi":"10.1039/D4TB00679H","DOIUrl":"10.1039/D4TB00679H","url":null,"abstract":"Soft bioelectronic neural interfaces have great potential as mechanically favourable alternatives to implantable metal electrodes. In this pursuit, conductive hydrogels (CHs) are particularly viable, combining tissue compliance with the required electrochemical characteristics. Physically-aggregated CHs offer an additional advantage by their facile synthesis into injectable systems, enabling minimally invasive implantation, though they can be impeded by a lack of control over their particle size and packing. Guided by these principles, an injectable PEDOT:PSS/acetic acid-based hydrogel is presented herein whose mechanical and electrochemical properties are independently tuneable by modifying the relative acetic acid composition. The fabrication process further benefits from employing batch emulsion to decrease particle sizes and facilitate tighter packing. The resulting material is stable and anatomically compact upon injection both in tissue phantom and ex vivo, while retaining favourable electrochemical properties in both contexts. Biphasic current stimulation yielding voltage transients well below the charge injection limit as well as the gel's non-cytotoxicity further underscore its potential for safe and effective neural interfacing applications.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on the role of strontium in biodegradable metals 全面回顾锶在可生物降解金属中的作用。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-07-29 DOI: 10.1039/D4TB00779D

Huafang Li and Luqing Ma

{"title":"A comprehensive review on the role of strontium in biodegradable metals","authors":"Huafang Li and Luqing Ma","doi":"10.1039/D4TB00779D","DOIUrl":"10.1039/D4TB00779D","url":null,"abstract":"Biodegradable metals, including magnesium, iron, and zinc alloys, have attracted extensive attention due to their good biodegradability and biocompatibility. However, the mechanical properties and corrosion rates of most biodegradable metallic materials have not yet reached the ideal level required for clinical applications. Strontium, as an element of Group IIA in the periodic table of elements, has similar chemical and biological properties to calcium. It can promote bone tissue development and increase bone strength. In addition, strontium can also promote angiogenesis and facilitate the repair of infarcted heart activity. Thus, strontium is commonly used as one of the most alloying elements to improve the in vitro and in vivo properties of biodegradable metals. Besides, strontium is also widely used in various bioactive coatings to improve the comprehensive properties of biodegradable metals. This paper outlines the role of strontium in the human body and summarizes recent research and applications of strontium-containing biodegradable metallic materials. Finally, this paper also provides an outlook on the challenges faced in applying and researching strontium in biodegradable metals.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0