Journal of Materials Chemistry B最新文献

{"title":"Recent advances in near-infrared-II (NIR-II) small molecule fluorophores for cancer theranostics","authors":"Qinghua Zhu, Jing Nie, Yamei Li, Linlin Ni, Xiaoni Kong, Honglei Zhou and Jiyong Wu","doi":"10.1039/D5TB01249J","DOIUrl":"10.1039/D5TB01249J","url":null,"abstract":"<p >Phototherapy has emerged as a prominent cancer treatment modality, achieving precise tumor ablation <em>via</em> light-driven photochemical or photothermal effects in target tissues using specific wavelengths. In the field of phototherapy, near-infrared-II (NIR-II) fluorescence imaging has emerged as an exceptionally effective method for deep tissue imaging <em>in vivo</em>, providing superior tissue penetration, high sensitivity, and outstanding spatiotemporal resolution. Strategic design of small-molecule organic NIR-II fluorophores with customizable molecular structures, superior optical properties, and high biocompatibility is critical for leveraging NIR-II imaging in precise cancer diagnosis and therapy. This review highlights molecular engineering strategies such as donor–acceptor optimization, π-system expansion, and aggregation suppression to improve emission wavelength, quantum yield, and photostability. We further evaluate their dual roles in real-time tumor imaging and photodynamic/photothermal therapy, emphasizing structure–performance relationships. Current challenges such as low quantum efficiency (&lt;1%) and aggregation-induced quenching are discussed alongside emerging solutions like nanocarrier encapsulation and AI-driven molecular design. These innovations advance clinical translation by integrating preclinical insights into image-guided precision oncology systems.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 10836-10852"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid photo-crosslinked decellularized extracellular matrix scaffold from porcine Achilles tendon: a biocompatible and non-immunogenic matrix for tissue engineering","authors":"Shreeyash Shelar, Ujjwal Gupta, Mamta Kumari, Mohammed Shabib, Bitan Guchhait, Chandan Mandal, Santanu Kaity and Subhadeep Roy","doi":"10.1039/D5TB01038A","DOIUrl":"10.1039/D5TB01038A","url":null,"abstract":"<p >A considerable number of xenogeneic tissues are still underutilised due to concerns about immunogenicity, biocompatibility, and structural integrity. Decellularized extracellular matrix (dECM) hydrogels are gaining popularity due to their ability to mimic natural biochemical cues and structural integrity required for tissue regeneration. In this study, we used pig tendon tissues, which are commonly discarded, to create photo-crosslinked dECM hydrogels. We created and comprehensively examined tendon-derived dECM hydrogels processed with three different decellularization techniques, assessing their physicochemical properties, biocompatibility, and immunogenicity. SEM, XRD, and FTIR were used to characterize the dECM hydrogel's structural and biochemical integrity. SEM demonstrated an intact collagenous architecture, while XRD proved the presence of a natural collagen fibrillar structure. The FTIR study revealed intact amide I and II bands, indicating minimal ECM disruption. Rheological experiments revealed good shear-thinning behaviour, which improves injectability. Furthermore, TGA verified thermal stability in the groups, and swelling experiments revealed consistent hydrogel stability, with CD exhibiting the largest equilibrium swelling due to improved water–polymer interaction without compromising flexibility. THP-1 cells were grown on dECM hydrogels to test biocompatibility and immunogenicity. Cellular morphology examination demonstrated that THP-1 cells cultivated on dECM hydrogels had good cell viability and structural integrity. Notably, the constant expression of CD14, a major monocyte surface marker, without any pro-inflammatory activation demonstrated the hydrogels' non-immunogenic character, implying a broader applicability. Our research confirms that dECM hydrogels generated from tendon are durable biomaterials that do not elicit an immune response. A biocompatible and non-immunogenic matrix is produced by the optimised decellularization approach, which has great potential for use in tissue engineering and regenerative medicine.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11722-11738"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A photothermal therapy-based composite hydrogel for sequential management of inflammation control and bone regeneration in severe periodontitis†","authors":"Yuan Zhou, Maojiao Li, Huiyu Zheng, Bo Huang and Guiting Liu","doi":"10.1039/D5TB01510C","DOIUrl":"10.1039/D5TB01510C","url":null,"abstract":"<p >Chronic periodontitis remains a global issue in oral health and it is still a significant challenge to achieve the sequential management of inflammation control and bone repair. Herein, the antibiotic levofloxacin (LF) was loaded onto PDA-modified MXene (PDMM) 2D-composite nanosheets and embedded into the injectable hydrogel matrix of hyaluronic acid methacrylate (HAMA) to construct a 2D-nanomaterial composite hydrogel treatment platform (PDMM@LF-HAMA), which can initially control inflammation through antibacterial effects, alleviate diffuse gingival bleeding and then promote bone regeneration with further photothermal therapy. The composite hydrogel exhibited mild photothermal effects under near infrared (NIR) light and excellent photothermal conversion efficiency, which can promote cell proliferation and osteogenic differentiation <em>in vitro</em>. Finally, an <em>in vivo</em> experimental periodontitis model further demonstrated that the composite hydrogel achieved inflammation control within 2 weeks. Combined with NIR (808 nm, 0.4 W cm<small>⁻²</small>), PDMM@LF-HAMA had a thicker periodontal epithelial fibrous layer and better alveolar bone height and morphology compared to the group without NIR after 8 weeks, while it also enhanced the expression levels of OCN and Runx2. Overall, this work provides an exploratory approach for the comprehensive management of periodontitis through the whole stage.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 33","pages":" 10225-10238"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralized double-network hydrogels for the controlled release and improved stability of antimicrobial peptides","authors":"Yu Tian, Shixiong Zhang, Wentao Zhai, Chenxi Duan, Donghua Zhang, Jun Hu and Yi Zhang","doi":"10.1039/D5TB01186H","DOIUrl":"10.1039/D5TB01186H","url":null,"abstract":"<p >Antimicrobial peptides (AMPs) have attracted considerable attention in chronic wound management and the prevention of implant-associated infections due to their excellent bactericidal activity, low toxicity, and great biocompatibility. However, their poor stability and uncontrolled release often result in transient efficacy, necessitating frequent administration. Developing a delivery system that ensures both sustained release and mechanical stability is crucial for the clinical translation of AMPs. To address these challenges, in this study, a Ca/P mineralized double-network (DN) hydrogel was developed, which consisted of a physically crosslinked polyvinyl alcohol (PVA) and a previously designed AMP termed IK3, to achieve controlled AMP release. The findings demonstrated that mineralization enhanced the structural integrity of the DN hydrogel while acting as a diffusion-regulating barrier to enable controlled and sustained IK3 release. <em>In vitro</em> antibacterial assays revealed sustained and potent antibacterial activity, with the mineralized hydrogel retaining strong efficacy after two months in PBS and demonstrating excellent biocompatibility. Compared to unmineralized hydrogels, the mineralized DN hydrogel exhibited superior mechanical strength, prolonged antimicrobial efficacy, and a reduced initial burst release. This study presents a novel strategy for optimizing AMP delivery, offering a multifunctional platform with exceptional potential for chronic wound healing and implant-associated infection prevention.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 34","pages":" 10500-10511"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01186h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red-light-triggered microenvironment-responsive sustained carbon monoxide release for enhanced tumor therapy","authors":"Jiahui Sheng, Yao Wang, Fei Li, Guihai Gan, Yao Lu, Lun-lan Li and Jian Cheng","doi":"10.1039/D5TB01166C","DOIUrl":"10.1039/D5TB01166C","url":null,"abstract":"<p >Carbon monoxide (CO), a gasotransmitter, has gained attention as a potential therapeutic agent in cancer treatment. The precise and sustained release of CO is crucial for minimizing its toxicity and enhancing its therapeutic efficacy. We have developed a light-gated, microenvironment-responsive CO release platform for precise and sustained CO delivery. FeCO was used as the CO donor and integrated into the micelle core containing tertiary amine (TA) residues and a Pd-based photosensitizer (PdTPTBP). In the first stage, the H<small>₂</small>O<small>₂</small> generated during light irradiation, in combination with GSH, triggers the release of CO and Fe<small>²⁺</small> from FeCO. Subsequently, Fe<small>²⁺</small> reacts with H<small>₂</small>O<small>₂</small><em>via</em> a Fenton reaction, further promoting sustained CO release under dark conditions in the second stage. Light irradiation acts as a gating mechanism to achieve precise and sustained CO release. This CO delivery platform can be efficiently internalized by 4T1 tumor cells and, upon 630 nm light irradiation, releases CO intracellularly to induce ferroptosis. By synergistically disrupting mitochondrial function, it exhibits effective antitumor activity in 4T1 tumor-bearing mice.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 10916-10925"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End group chemistry modulates physical properties and biomolecule release from biodegradable polyesters","authors":"Matthew A. Borrelli, Jordan J. P. Warunek, Tarini Ravikumar, Stephen C. Balmert and Steven R. Little","doi":"10.1039/D5TB00816F","DOIUrl":"10.1039/D5TB00816F","url":null,"abstract":"<p >Long-acting injectable protein therapeutics are a rapidly advancing arm of pharmaceuticals. A promising and versatile class of such formulations involves encapsulation of therapeutic protein within poly(lactic-<em>co</em>-glycolic acid) (PLGA) degradable microparticles (MP) to shield the protein from enzymatic degradation and control the release rate. However, models based on degradation and erosion of PLGA polymer matrices do not always fully capture release behavior, due in part to electrostatic interactions between the polymer terminal group and encapsulated compound. The repertoire of functionalized PLGA polymers commercially available has now expanded to include terminal group chemistries that may significantly alter polymer characteristics including charge, hydrophobicity, and erosion. This work aims to explore how PLGA terminal group chemistry affects polymer physical properties and charged biomolecule release kinetics. PLGA with hydroxyl (PLGA–OH), amine (PLGA–NH<small>₂</small>), or carboxylic acid (PLGA–COOH) terminal groups that have neutral, positive, or negative charge, respectively, were evaluated. Experiments assessing the physical properties of the polymers indicate PLGA–NH<small>₂</small> has reduced hydrophobicity, degrades faster, exhibits emulsion stabilizing behavior, and has reduced phagocytic clearance by bone marrow derived macrophages. Charged biomolecule release rates are increased from PLGA–NH<small>₂</small> MPs and slightly accelerated from PLGA–OH MPs, compared to PLGA–COOH MPs. These studies provide further insight into the interactions between charged biomolecules and the encapsulating polymer and could provide additional tools to tune release for various protein therapeutics that experience such interactions.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 34","pages":" 10621-10634"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene-based neural electrodes: from materials and device fabrication to properties","authors":"Muhammed Zahid Doğan and Cem Bayram","doi":"10.1039/D5TB01040C","DOIUrl":"10.1039/D5TB01040C","url":null,"abstract":"<p >Neural electrodes serve as a conduit for the purpose of facilitating electrophysiological communication between neurons and external electronic devices. These electrodes are extensively utilized in both neuroscientific research and in the domains of neural prosthetics and neuromodulation practices. Recently, graphene and its numerous derivatives have emerged as a transformative material in bioelectronics and electrochemical applications. Depending on the device fabrication process and preferred graphene derivative, graphene-based neural electrodes can offer fatigue-resistant flexibility, high electrical conductivity, excellent optical transparency (97.7%), increased specific surface area, superior electrochemical durability, composability, and advanced surface functionalization properties, which can make them an ideal choice for their intended <em>in vivo</em> or <em>in vitro</em> applications. In this review, we comparatively summarize the existing work on graphene and graphene related material-based electrochemical neural electrodes through the key studies of diverse approaches to provide an overview of the field, highlight the motivations behind the research, and identify potential improvement strategies for future investigations.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 34","pages":" 10420-10439"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01040c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: An implantable composite scaffold for amplified chemodynamic therapy and tissue regeneration","authors":"Jiafei Chen, Shiqi Wan, Yike Fu, Yi Zhou, Xiang Li and Huiming Wang","doi":"10.1039/D5TB90086G","DOIUrl":"10.1039/D5TB90086G","url":null,"abstract":"<p >Correction for ‘An implantable composite scaffold for amplified chemodynamic therapy and tissue regeneration’ by Jiafei Chen <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2023, <strong>11</strong>, 3151–3163, https://doi.org/10.1039/D2TB02699F.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 33","pages":" 10369-10370"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90086g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A calcium manganese-based pancatalytic nanozyme as a cell pyroptosis inhibitor for efficient inflammatory bowel disease treatment","authors":"Lili Liu, Wenting Ye, Yanqiu Duan, Xinran Song, Li Ding, Yu Chen and Meiqi Chang","doi":"10.1039/D5TB01210D","DOIUrl":"10.1039/D5TB01210D","url":null,"abstract":"<p >Inflammatory bowel disease (IBD) is a chronic inflammatory disorder marked by dysregulated immune responses and pyroptosis of intestinal epithelial cells, a type of programmed cell death that aggravates inflammation. Current therapeutic strategies frequently encounter limitations in both efficacy and specificity. Herein, we developed a calcium manganese-based (CaMn<small>₂</small>O<small>₄</small>) pancatalytic nanozyme designed to mitigate pyroptosis and alleviate IBD symptoms. The calcium manganese-based nanozyme exhibits dual enzyme (catalase and superoxide dismutase)-mimetic catalytic activities, scavenging reactive oxygen species and suppressing GSDMD cleavage, a key mediator of pyroptosis. <em>In vitro</em> studies demonstrated that the CaMn<small>₂</small>O<small>₄</small> nanozyme significantly reduced pyroptotic cell death in lipopolysaccharide (LPS)/nigericin (Ni)-stimulated cells. In a murine colitis model, CaMn<small>₂</small>O<small>₄</small>-based nanozyme treatment attenuated inflammatory infiltration, preserved epithelial barrier integrity, and downregulated pyroptosis-related markers. This study highlights the potential of pancatalytic nanotherapy targeting pyroptosis as a novel strategy for IBD treatment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11381-11391"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon dot sensitized hollow Co9S8−x for enhanced sonodynamic cancer therapy","authors":"Lu Zhang, Zuopei Wang, Yi Ding, Xinjie Xie, Bo Sheng, Yang Zhuang, Jinyan Hu, Huibiao Zhang and Yi Lu","doi":"10.1039/D5TB01233C","DOIUrl":"10.1039/D5TB01233C","url":null,"abstract":"<p >Sonodynamic therapy activates sonosensitizers through US to generate a large amount of reactive oxygen species (ROS), which causes apoptosis of tumor cells and achieves a therapeutic effect against tumors. However, the excessively wide bandgap of inorganic sonosensitizers and the easy recombination of electron–hole pairs limit the yield of ROS of sonosensitizers. Herein, for the first time, we report carbon dot (CD)-sensitized hollow Co<small>₉</small>S<small>_{8−<em>x</em>}</small> as a novel inorganic sonosensitizer for enhanced sonodynamic tumor therapy. The presence of sulfur vacancies endows Co<small>₉</small>S<small>₈</small> with excellent sonodynamic and chemodynamic activities. Furthermore, CDs with good sonodynamic activity are utilized to form CD@Co<small>₉</small>S<small>_{8−<em>x</em>}</small> heterojunctions with hollow Co<small>₉</small>S<small>_{8−<em>x</em>}</small>, realizing the cascaded amplification of the ROS yield. The significantly increased ROS level induces a powerful effect of cell apoptosis, thus completely eradicating tumors. Overall, this work delivers useful insights for utilizing vacancy engineering and heterojunction engineering to achieve enhanced sonodynamic tumor therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11371-11380"},"PeriodicalIF":6.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}