Journal of Materials Chemistry B最新文献_第9页

Capture and lyase-triggered release of circulating tumor cells using a disposable microfluidic chip embedded with core/shell nylon-6/Ca(ii)-alginate immunofiber mats† 使用嵌入核/壳尼龙-6/Ca(II)-海藻酸盐免疫纤维垫的一次性微流控芯片捕获和裂解酶触发的循环肿瘤细胞释放。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-03-04 DOI: 10.1039/D4TB02226B

Hung-Yen Ke, Chi-Jung Chang, Shih-Ying Sung, Chien-Sung Tsai, Feng-Yen Lin and Jem-Kun Chen

{"title":"Capture and lyase-triggered release of circulating tumor cells using a disposable microfluidic chip embedded with core/shell nylon-6/Ca(ii)-alginate immunofiber mats†","authors":"Hung-Yen Ke, Chi-Jung Chang, Shih-Ying Sung, Chien-Sung Tsai, Feng-Yen Lin and Jem-Kun Chen","doi":"10.1039/D4TB02226B","DOIUrl":"10.1039/D4TB02226B","url":null,"abstract":"High-efficiency capture, release, and reculture of circulating tumor cells (CTCs) can significantly advance individualized cancer treatments. To achieve efficient CTC release without compromising their viability for subsequent reculture, an effective CTC capture/release system was developed. Nylon-6 (N6) and a cross-linked alginate hydrogel with Ca(II) were used as the shell and core, respectively, to prepare N6/Ca-Alg immunofiber mats using coaxial electrospinning. A 3 wt% concentration of Ca(II) was used to increase the viscosity of the alginate solution and generate a degradable coating on the N6 fiber. After modification with streptavidin and anti-EpCAM, the N6/Ca-Alg immunofiber mat was embedded within a disposable microfluidic chip to investigate the capture capacity of CTCs. The maximum adsorption capacity of CTCs was approximately 34 cells per mm2, while the viability of the captured cells was 95.1% after being released from the fibrous mats. The outer Ca-alginate hydrogel coating effectively enhanced the viability of the released cells for reculture. In spiked blood samples, our microfluidic system was able to specifically identify DLD1 cells from 10 mL of human whole blood at a concentration of 65.6 cells per mL with 67.9% efficiency within 30 minutes. Under the flow of alginate lyase solution at 0.4 mg mL−1, the reculture efficiency of the released cells after 7 days reached 274.5%. Our proposed method provides an ideal fibrous mat to be embedded within a microfluidic chip for capturing and releasing CTCs for precision medicine applications, using recultured CTCs in individualized anti-tumor therapies.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 17","pages":" 5027-5040"},"PeriodicalIF":6.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential drug release nanocomposites for synergistic therapy in disease treatment 序贯释药纳米复合材料在疾病治疗中的协同治疗。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-03-04 DOI: 10.1039/D5TB00026B

Siyuan Luo, Chenyu Zhao, Rong Wang and Daocheng Wu

{"title":"Sequential drug release nanocomposites for synergistic therapy in disease treatment","authors":"Siyuan Luo, Chenyu Zhao, Rong Wang and Daocheng Wu","doi":"10.1039/D5TB00026B","DOIUrl":"10.1039/D5TB00026B","url":null,"abstract":"Time-sequenced drug release, or sequential drug release, represents a pivotal strategy in the synergistic treatment of diseases using nanocomposites. Achieving this requires the rational integration of multiple therapeutic agents within a single nanocomposite, coupled with precise time-controlled release mechanisms. These nanocomposites offer many advantages, including enhanced therapeutic synergy, reduced side effects, attenuated adverse interactions, improved stability and optimized drug utilization. Consequently, research in the field of drug delivery and synergistic therapy has become increasingly important. Currently, sequential drug release research is still in the data collection and basic research stages, and its potential has not yet been fully explored. Although prior studies have explored the sequential drug release strategy in various contexts, a comprehensive review of the underlying mechanisms and their applications in nanocomposites remains scarce. This review categorizes different types of sequential drug release strategies and summarizes diverse nanocomposites, focusing on both physical approaches driven by structural variations and chemical methods based on stimulus-responsive mechanisms. Furthermore, we highlight the major applications of sequential drug release strategies in the treatment of various diseases and detail their therapeutic efficacy. Finally, emerging trends and challenges in advancing sequential drug release strategies based on nanocomposites for disease treatment are also discussed.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 14","pages":" 4313-4329"},"PeriodicalIF":6.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the synergistic effects of Ag, Li and Sr on Zn alloys in enhancing orthopedic repair potential 揭示Ag、Li和Sr对Zn合金增强矫形修复潜能的协同效应。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-03-04 DOI: 10.1039/D5TB00111K

Huafang Li, Luqing Ma and Yingying Li

{"title":"Unraveling the synergistic effects of Ag, Li and Sr on Zn alloys in enhancing orthopedic repair potential","authors":"Huafang Li, Luqing Ma and Yingying Li","doi":"10.1039/D5TB00111K","DOIUrl":"10.1039/D5TB00111K","url":null,"abstract":"Recently, Li, which can greatly enhance the mechanical characteristics of zinc alloys, Ag, which has antibacterial properties, and Sr, which promotes bone formation, have been widely applied in biodegradable alloys. However, to our knowledge, there has been no research on the combined effects of Ag, Li, and Sr in zinc alloys. To address this, we have created a new quaternary alloy (Zn–3Ag–0.1Li–0.1Sr). The incorporation of Ag, Li, and Sr increased the yield strength (YS) of the at-cast (AC) zinc alloy to 188.83 ± 12.38 MPa. After extrusion and hot rolling, the strong plasticity of the alloy was further significantly enhanced, with ultimate tensile strength (UTS) exceeding 400 MPa, YS exceeding 350 MPa, and elongation (EL) greater than 50%. An in vitro cell study revealed that after three days of culture with a 50% extract, the proliferation rate of MC3T3-E1 cells was 101.527 ± 0.129%, and the cells maintained a healthy spindle-shaped appearance. The antibacterial experiments also demonstrated that the Zn–3Ag–0.1Li–0.1Sr quaternary alloy has strong antibacterial properties against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Therefore, the biodegradable Zn–3Ag–0.1Li–0.1Sr quaternary alloy, which exhibits high strength, good cytocompatibility, and satisfactory antibacterial performance, has greater potential for application in the field of orthopedic repair.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 4006-4019"},"PeriodicalIF":6.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BAPTA-based potentiometric polymer sensor: towards sensing inflammations and infections† 基于bapta的电位聚合物传感器：用于感知炎症和感染。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-03-03 DOI: 10.1039/D4TB02586E

Nikol Janić, Hanna Zhukouskaya, Peter Černoch, Jiří Pánek, Jan Svoboda, Milena Hajná, Alena Řezníčková, Elena Tomšík and Martin Hrubý

{"title":"BAPTA-based potentiometric polymer sensor: towards sensing inflammations and infections†","authors":"Nikol Janić, Hanna Zhukouskaya, Peter Černoch, Jiří Pánek, Jan Svoboda, Milena Hajná, Alena Řezníčková, Elena Tomšík and Martin Hrubý","doi":"10.1039/D4TB02586E","DOIUrl":"10.1039/D4TB02586E","url":null,"abstract":"Potentiometric ion sensors represent a significant subgroup of electrochemical sensors. In this study, we have developed a potentiometric sensor using an electrically conductive copolymer of 2,2′-bithiophene (BT) and 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) for the selective detection of Ca2+ ions in extracellular interstitial fluids. The integration of BAPTA with its highly selective calcium chelating properties into a polymer matrix via electrochemical polymerization results in a sensitive conductive polymer layer that effectively detects the presence of calcium ions. This sensor aims at the early detection of inflammation or infection around implants because local calcium concentration is strongly elevated in interstitial fluid in such pathologies. The potentiometric study proves the incorporation of BAPTA into the polymer matrix was successful and its potential decreased upon calcium binding demonstrating the Nernstian behavior with a slope of approximately 20 ± 0.3 mV per decade in the concentration range from 0.1 mM to 1 mM. Moreover, the selectivity coefficient of –0.4 was measured by SSM and calculated from the Nicolsky–Eisenmann equation, which indicates selectivity towards Ca2+ ions with respect to Mg2+ ions.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 13","pages":" 4157-4165"},"PeriodicalIF":6.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02586e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raman imaging investigation of hepatic LX-2 cell reversion under different lipidic treatments† 不同脂质处理下肝脏LX-2细胞逆转的拉曼成像研究。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-03-03 DOI: 10.1039/D4TB02082K

Gina Valentino, Assumpta Widak, Bernadette Scopacasa, Luca Tirinato, Elvira Immacolata Parrotta, Gerardo Perozziello, Arturo Pujia, Giovanni Cuda, Paola Luciani and Patrizio Candeloro

{"title":"Raman imaging investigation of hepatic LX-2 cell reversion under different lipidic treatments†","authors":"Gina Valentino, Assumpta Widak, Bernadette Scopacasa, Luca Tirinato, Elvira Immacolata Parrotta, Gerardo Perozziello, Arturo Pujia, Giovanni Cuda, Paola Luciani and Patrizio Candeloro","doi":"10.1039/D4TB02082K","DOIUrl":"10.1039/D4TB02082K","url":null,"abstract":"Liver fibrosis resulting from chronic liver injury is characterized by increased extracellular matrix deposition and inflammation, which leads to excessive scar tissue formation. Targeting activated hepatic stellate cells (HSCs), which are the primary drivers of fibrogenesis, stands out as one of the most compelling therapeutic approaches in this regard. In a healthy liver, HSCs remain quiescent and store vitamin A in cytoplasmic lipid droplets. As a consequence of HSC activation and transdifferentiation to a proliferative myofibroblast-like state upon fibrotic stimuli, the distinctive phenotypic feature of the lipid droplets gets lost. While the reversal of activated HSCs is feasible, understanding the quiescent-like state following injury resolution is crucial for effective fibrosis treatment. This study explores the induced quiescent-like state of naïve immortalized human hepatic stellate (LX-2) cells when treated with soybean phospholipid that contains 75% phosphatidylcholine (S80). The lipid profile of the newly formed lipid droplets was analyzed using Raman imaging, which is a label-free technique well-suited for lipidomics. Results indicate the presence of distinct lipid profiles despite maintaining a quiescent-like state, suggesting that diverse mechanisms govern the active-to-inactive state transition. Additionally, our findings support the fact that each hepatic cell state is composed of heterogeneous subpopulations. This emphasizes the complexity of liver fibrosis and highlights the need for a comprehensive understanding of cellular states to develop targeted therapies.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 13","pages":" 4085-4093"},"PeriodicalIF":6.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02082k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luminescent ultrashort peptide hydrogelator with enhanced photophysical implications and biocompatibility† 具有增强光物理意义和生物相容性的发光超短肽凝胶。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-03-03 DOI: 10.1039/D4TB02687J

Aanchal Kumari, Gitanjali Bangal, Basab Kanti Das, Malay Kumar Baroi, Mamta Kumari, Priyanka Das, Kolimi Prashanth Reddy, Rakibul Islam, Devendra Kumar Dhaked, Bapan Pramanik, Subhadeep Roy and Sahnawaz Ahmed

{"title":"Luminescent ultrashort peptide hydrogelator with enhanced photophysical implications and biocompatibility†","authors":"Aanchal Kumari, Gitanjali Bangal, Basab Kanti Das, Malay Kumar Baroi, Mamta Kumari, Priyanka Das, Kolimi Prashanth Reddy, Rakibul Islam, Devendra Kumar Dhaked, Bapan Pramanik, Subhadeep Roy and Sahnawaz Ahmed","doi":"10.1039/D4TB02687J","DOIUrl":"10.1039/D4TB02687J","url":null,"abstract":"Luminescent peptide hydrogelators have garnered significant attention in biomedical sciences and materials chemistry due to their biological relevance and tunable photophysical features. In this work, we have designed and synthesized a novel ultrashort peptide hydrogelator comprising a tripeptide sequence (FFE) integrated with 1,8-naphthalimide (NI) as an aggregation-induced emissive unit having rich and tuneable photophysical properties. The hydrogelator could self-assemble and form a self-supporting hydrogel having a highly ordered intertwined network structure at pH 5.5 with a minimum gelation concentration of 1 wt/v%. Interestingly, due to the presence of the emissive unit, the assembly could demonstrate strong blue luminescence, which has been thoroughly investigated experimentally. Moreover, spectroscopic investigations and molecular dynamics simulation studies suggest the formation of a β-sheet structure through extended intermolecular H-bonding interactions within the peptide backbones and the strong π–π-stacking interaction among aromatic units, which drive the self-assembly and hydrogelation. The emissive unit of the peptide could arrange in a J-type aggregation pattern and adopt right-handed helical induced chirality in the assembled state. Additionally, the system could exhibit a high safety profile and excellent biocompatibility, when tested in a series of cell lines in vitro. Finally, the intracellular uptake of the system has been exploited, showcasing its luminescence characteristics for potential applications in cellular imaging. The luminescent system holds significant promise for advancing cellular imaging techniques, offering new avenues for research in the future. Briefly, this work highlights the importance of luminescent ultrashort peptide hydrogelators for developing next-generation low-cost functional biomaterials.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 14","pages":" 4406-4418"},"PeriodicalIF":6.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionalized ZIF-8 as a versatile platform for drug delivery and cancer therapy: strategies, challenges and prospects 功能化ZIF-8作为药物传递和癌症治疗的多功能平台：策略、挑战和前景。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-28 DOI: 10.1039/D4TB02289K

Wenyue Gao, Xinping Han, Ling Li, Yan Xu, Min Xu, Zhu Gao and Cuijuan Wang

{"title":"Functionalized ZIF-8 as a versatile platform for drug delivery and cancer therapy: strategies, challenges and prospects","authors":"Wenyue Gao, Xinping Han, Ling Li, Yan Xu, Min Xu, Zhu Gao and Cuijuan Wang","doi":"10.1039/D4TB02289K","DOIUrl":"10.1039/D4TB02289K","url":null,"abstract":"This review discusses the functionalization strategies of ZIF-8 and challenges and future developments in ZIF-8-based platforms for drug delivery and cancer therapy. We systematically evaluate a series of innovative ZIF-8 functionalization methods, including atomic doping, introduction of targeting molecules, and biomimetic mineralization technology, to achieve precise drug release. These functionalization strategies significantly enhance the targeted delivery and controlled release properties of ZIF-8, broaden the diversity of drug delivery systems, maximize therapeutic effects, and minimize systemic toxicity. In addition, this review explores the important role of ZIF-8 in tumor therapy. Its ability to encapsulate multiple therapeutic agents and its responsiveness to the tumor microenvironment significantly improve the therapeutic effect and reduce the side effects of traditional treatments. By integrating multiple therapeutic agents and performing surface modification, ZIF-8-based platforms may provide personalized and efficient treatment options for drug-resistant or recurrent cancers. This review also comprehensively discusses the synthesis methods, drug loading capacity, and potential clinical applications of ZIF-8, emphasizing the need to optimize its large-scale production and reproducibility. In addition, further studies on the long-term biocompatibility and biodegradability of ZIF-8-based systems are essential to ensure their safety in long-term treatment. In summary, this review highlights the structural advantages and significant therapeutic potential of ZIF-8 and calls for the transition of ZIF-8 from laboratory research to clinical application to provide more targeted, efficient, and friendly cancer treatment options.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3758-3785"},"PeriodicalIF":6.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose derived mesenchymal stem cell-seeded regenerated silk fibroin scaffolds reverse liver fibrosis in mice† 脂肪源性间充质干细胞种子再生丝素蛋白支架逆转小鼠肝纤维化。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-26 DOI: 10.1039/D5TB00275C

Weilong Li, Xiaonan Shi, Daxu Zhang, Jingjing Hu, Shuo Zhao, Shujun Ye, Jingyi Wang, Xiaojiao Liu, Qian Zhang, Zhanbo Wang, Yaopeng Zhang and Li Yan

{"title":"Adipose derived mesenchymal stem cell-seeded regenerated silk fibroin scaffolds reverse liver fibrosis in mice†","authors":"Weilong Li, Xiaonan Shi, Daxu Zhang, Jingjing Hu, Shuo Zhao, Shujun Ye, Jingyi Wang, Xiaojiao Liu, Qian Zhang, Zhanbo Wang, Yaopeng Zhang and Li Yan","doi":"10.1039/D5TB00275C","DOIUrl":"10.1039/D5TB00275C","url":null,"abstract":"Liver fibrosis (LF) is an important process in the progression of chronic liver disease to cirrhosis. We have previously demonstrated that a regenerated silk fibroin scaffold loaded with adipose-derived stem cells (RSF + ADSCs) can repair acute liver injury. In this study, we established a chronic LF animal model using carbon tetrachloride (CCl4) and a high-fat diet. We then investigated the liver repair capacity after transplanting RSF + ADSC scaffolds and RSF scaffolds onto the liver surface of mice. Compared with the control group, the concentrations of ALT and AST in the serum were significantly reduced in the RSF and RSF + ADSC groups. HE staining and Masson trichrome staining revealed a decrease in the SAF score in both the RSF and RSF + ADSC groups. Meanwhile, the biomarkers of blood vessels and bile ducts, such as CD34, ERG, muc1, and CK19, were significantly elevated in the RSF + ADSC group. Finally, transcriptome analysis showed that the PPAR signaling pathway, which inhibits liver fibrosis, was significantly upregulated in both the RSF and RSF + ADSC groups. Our study suggests that, compared with RSF scaffolds alone, RSF + ADSCs have a significant repair effect on chronic LF in mice.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 13","pages":" 4201-4213"},"PeriodicalIF":6.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00275c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MXenes and MXene-based composites for biomedical applications 用于生物医学应用的MXenes和MXenes基复合材料。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-26 DOI: 10.1039/D4TB02834A

Taposhree Dutta, Parvej Alam and Satyendra Kumar Mishra

{"title":"MXenes and MXene-based composites for biomedical applications","authors":"Taposhree Dutta, Parvej Alam and Satyendra Kumar Mishra","doi":"10.1039/D4TB02834A","DOIUrl":"10.1039/D4TB02834A","url":null,"abstract":"MXenes, a novel class of two-dimensional materials, have recently emerged as promising candidates for biomedical applications due to their specific structural features and exceptional physicochemical and biological properties. These materials, characterized by unique structural features and superior conductivity, have applications in tissue engineering, cancer detection and therapy, sensing, imaging, drug delivery, wound treatment, antimicrobial therapy, and medical implantation. Additionally, MXene-based composites, incorporating polymers, metals, carbon nanomaterials, and metal oxides, offer enhanced electroactive and mechanical properties, making them highly suitable for engineering electroactive organs such as the heart, skeletal muscle, and nerves. However, several challenges, including biocompatibility, functional stability, and scalable synthesis methods, remain critical for advancing their clinical use. This review comprehensively overviews MXenes and MXene-based composites, their synthesis, properties, and broad biomedical applications. Furthermore, it highlights the latest progress, ongoing challenges, and future perspectives, aiming to inspire innovative approaches to harnessing these versatile materials for next-generation medical solutions.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 14","pages":" 4279-4312"},"PeriodicalIF":6.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dendritic polyglutamic acid-chelerythrine nanocomplex for the reversal of bacterial tooth decay† 树突状聚谷氨酸-车腥草碱纳米复合物逆转细菌蛀牙。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-26 DOI: 10.1039/D4TB02748E

Yan Zhang, Yihua Liu, Fan Fan, Hongbo Zhang, Qiangwei Xin, Shiran Sun, Xinyuan Xu, Liwei Zheng, Yang Liu, Chunmei Ding, Mingming Ding and Jianshu Li

{"title":"Dendritic polyglutamic acid-chelerythrine nanocomplex for the reversal of bacterial tooth decay†","authors":"Yan Zhang, Yihua Liu, Fan Fan, Hongbo Zhang, Qiangwei Xin, Shiran Sun, Xinyuan Xu, Liwei Zheng, Yang Liu, Chunmei Ding, Mingming Ding and Jianshu Li","doi":"10.1039/D4TB02748E","DOIUrl":"10.1039/D4TB02748E","url":null,"abstract":"Caries begin with an imbalance between demineralization and remineralization due to the continuous acid production by cariogenic bacteria. However, the development of dental materials that could prevent and treat caries via a simple and efficient mechanism has always been a challenge. To address this issue, therapeutic nanoparticles composed of a dendritic polyglutamic acid (DPGlu) and chelerythrine (CHE) complex (DPGlu@CHE) were developed via hydrophobic interactions and hydrogen bonds. DPGlu@CHE could be adsorbed onto the tooth surface, releasing CHE rapidly under acidic conditions to remove cariogenic bacteria, subsequently inducing tooth surface remineralization in situ. Our results demonstrated that more than 99% of Streptococcus mutans on the tooth surface were killed, and 84% of the mechanical properties of tooth were restored within 2 weeks. Thus, DPGlu@CHE was proven to be a safe and effective enamel restoration material in vitro, and its safety was verified in vivo, making it a promising mouthwash ingredient to maintain dental health.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 13","pages":" 4214-4224"},"PeriodicalIF":6.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0