Journal of Materials Chemistry B最新文献_第8页

Structural aspects of dimeric prodrug-based carrier-free nanomedicines for tumor chemotherapy†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-08 DOI: 10.1039/D4TB02850C

Chen Yang and Peng Liu

引用次数: 0

From window panes to bone regeneration: structure, viscosity and bioactivity of soda lime silicate glasses† 从窗玻璃到骨骼再生：钠钙硅酸盐玻璃的结构、粘度和生物活性。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-08 DOI: 10.1039/D4TB02414A

Zhaorui Jin, Daniel R. Neuville, Coraline Chartier, Pavel Kachanov, Scott Kroeker, Stéphane Gin, Jincheng Du and Delia S. Brauer

引用次数: 0

Luminescent bio-sensors via co-assembly of hen egg white lysozyme with Eu3+/Tb3+-complexes†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-07 DOI: 10.1039/D4TB01766H

Min Zhang, Miao Qiu, Zengkun Li, Rui Xu, Yao Wang, Wei Wang, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore and Jianguo Tang

{"title":"Luminescent bio-sensors via co-assembly of hen egg white lysozyme with Eu3+/Tb3+-complexes†","authors":"Min Zhang, Miao Qiu, Zengkun Li, Rui Xu, Yao Wang, Wei Wang, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore and Jianguo Tang","doi":"10.1039/D4TB01766H","DOIUrl":"10.1039/D4TB01766H","url":null,"abstract":"Protein crystals have advantageous properties as framework materials, such as porosity and organized, high-density functional groups with the potential for guest specificity. Thus, protein crystal materials open up vast opportunities for fluorescent species doping and drug sensing. In this work, we explore this frontier by combining two lanthanide complexes with hen egg white lysozyme (HEWL) and directly obtaining co deposited structures in one step using an anti-solvent method different from the previous two-step method. Cross-linking of the protein was achieved using glutaraldehyde, ensuring the stability of the assembly in diverse solvent environments. The use of glutaraldehyde achieved protein cross-linking, ensuring the stability of the components in various solvent environments, including no leakage of fluorescent substances in ultrapure water and anhydrous ethanol. Differential fluorescence quenching effects of amino acids on the two doped luminescent complexes were observed. Introduction of amino acids, varying in concentration and type, resulted in distinct fluorescence enhancement or quenching effects on the protein assembly loaded with the complexes, and the detection results are reflected through different fitting equations and parameters. By exploring the application of this hybrid material for amino acid detection, this work lays the groundwork for broader applications.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3198-3208"},"PeriodicalIF":6.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Development of a tannic acid- and silicate ion-functionalized PVA–starch composite hydrogel for in situ skeletal muscle repairing

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-06 DOI: 10.1039/D5TB90025E

Longkang Li, Huipeng Li, Zhentian Diao, Huan Zhou, Yanjie Bai and Lei Yang

引用次数: 0

Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-06 DOI: 10.1039/D4TB02524E

Xue Yan, Li-Xin Gao, Zi-Tong Cao, Su-Ya Gan, Yi-Qiu Fu, Jia Li, Da-Jun Xiang, Yu-Bo Zhou and Wen-Long Wang

{"title":"Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications†","authors":"Xue Yan, Li-Xin Gao, Zi-Tong Cao, Su-Ya Gan, Yi-Qiu Fu, Jia Li, Da-Jun Xiang, Yu-Bo Zhou and Wen-Long Wang","doi":"10.1039/D4TB02524E","DOIUrl":"10.1039/D4TB02524E","url":null,"abstract":"Although the benzimidazole moiety is a versatile heterocyclic unit that has been widely applied in optical materials and medicinal chemistry, there are few bifunctional small-molecule benzimidazole derivatives with bio-activity and fluorescence. In this work, a series of novel benzimidazole-salicylic acid molecules were designed and synthesized; their optical properties were evaluated and their potential biological application was explored. The representative compound 5q exhibited excellent fluorescence properties, displaying blue imaging in HeLa cells and zebrafish. Additionally, it exhibited high selectivity for Fe3+ ions and demonstrated a notable inhibitory activity with IC50 = 6.86 ± 2.82 μM against SHP1PTP. Further effort was applied to explore the potential capability of compound 5q to reactivate the activity of SHP1 when inhibited by Fe3+ ions, indicating that compound 5q could be a fluorescent modulator to adjust SHP1 enzyme activity in biological systems.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3633-3643"},"PeriodicalIF":6.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-06 DOI: 10.1039/D5TB90023A

Rui Wang, Yanfang Sun, Han Wang, Tianqi Liu, Amin Shavandi, Lei Nie, Khaydar E. Yunusov and Guohua Jiang

引用次数: 0

Mitochondria-targeting fluorescent probe with a pH/viscosity response for assisted detection of non-alcoholic fatty liver in mice†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-06 DOI: 10.1039/D4TB02711F

Xue Wang, Xu Zhou, Ze Zhang, Lingyi Shen, Xiufang Yan, Hong Xu, Carl Redshaw and Qi-Long Zhang

{"title":"Mitochondria-targeting fluorescent probe with a pH/viscosity response for assisted detection of non-alcoholic fatty liver in mice†","authors":"Xue Wang, Xu Zhou, Ze Zhang, Lingyi Shen, Xiufang Yan, Hong Xu, Carl Redshaw and Qi-Long Zhang","doi":"10.1039/D4TB02711F","DOIUrl":"10.1039/D4TB02711F","url":null,"abstract":"Cancer cells are characterized by high viscosity, low pH and high levels of reactive oxygen species. Both pH and viscosity are key indicators which can respond to the microenvironment of cancer cells and are also important indicators for monitoring fatty liver. Based on this, we have constructed a hemicarbocyanine fluorescent probe (HTC) possessing a D–D′(π)–π–A structure using phenol as an electron donor (D), a thiophene moiety as an electron donor and a partial π bridge. The fluorescent probe HTC exhibits pH-responsive properties, and the fluorescence intensity of the probe at 627 nm gradually decreases and the fluorescence at 720 nm gradually increases with the increase of pH for pH = 7 to 10.5. Meanwhile, with an increase of viscosity the fluorescent probe HTC exhibited gradually enhanced fluorescence at 627 nm, thus revealing a response to the change of viscosity. In addition, the fluorescent probe HTC can target mitochondria for cellular fluorescence imaging, and co-localized fluorescence imaging with the commercial mitochondrial probe Mito-Tracker Green with a Pearson's coefficient of 0.91. We have utilized the properties of the fluorescent probe HTC, which exhibits a pH and viscosity response, and have applied it to monitor the change of pH or viscosity in cells and differentiate between normal and cancerous cells, as well as for the identification of non-alcoholic fatty liver mice. In addition, the probe is easily metabolized in mice and has good biocompatibility.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3677-3684"},"PeriodicalIF":6.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: Growth factors regional patterned and photoimmobilized scaffold applied to bone tissue regeneration

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-05 DOI: 10.1039/D5TB90030A

Ling-Kun Zhang, Wu-Ya Chen, Hui-Min Wang, Chao Liu, Jiecheng He, Yunzhi Tang, Yuxuan Jiao and Yan-Qing Guan

引用次数: 0

Tailoring nanovectors for optimal neoantigen vaccine efficacy

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-05 DOI: 10.1039/D4TB02547D

Youshi Zheng, Bing Wang, Zhixiong Cai, Zisen Lai, Haijun Yu, Ming Wu, Xiaolong Liu and Da Zhang

{"title":"Tailoring nanovectors for optimal neoantigen vaccine efficacy","authors":"Youshi Zheng, Bing Wang, Zhixiong Cai, Zisen Lai, Haijun Yu, Ming Wu, Xiaolong Liu and Da Zhang","doi":"10.1039/D4TB02547D","DOIUrl":"10.1039/D4TB02547D","url":null,"abstract":"The primary objective of neoantigen vaccines is to elicit a robust anti-tumor immune response by generating neoantigen-specific T cells that can eradicate tumor cells. Despite substantial advancements in personalized neoantigen prediction using next-generation sequencing, machine learning, and mass spectrometry, challenges remain in efficiently expanding neoantigen-specific T cell populations in vivo. This challenge impedes the widespread clinical application of neoantigen vaccines. Nanovector-based neoantigen delivery systems have emerged as a promising solutions to this challenge. These nanovectors offer several advantages, such as enhanced stability, targeted intracellular delivery, sustained release, and improved antigen-presenting cell (APC) activation. Notably, they effectively deliver various neoantigen vaccine formulations (DC cell-based, synthetic long peptide (SLP)-based or DNA/mRNA-based) to APCs or T cells, thereby activating both CD4+ T and CD8+ T cells. This ultimately induces a specific anti-tumor immune response. This review focuses on recent innovations in neoantigen vaccine delivery vectors. We aim to identify optimal design parameters for vectors tailored to different neoantigen vaccine types, with an emphasis on enhancing the tumor microenvironment and stimulating the production of neoantigen-specific cytotoxic T cells. By maximizing the potential of these delivery systems, we aim to accelerate the clinical translation of neoantigen nanovaccines and advance cancer immunotherapy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 13","pages":" 4045-4058"},"PeriodicalIF":6.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision therapeutics for inflammatory bowel disease: advancing ROS-responsive nanoparticles for targeted and multifunctional drug delivery

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-05 DOI: 10.1039/D4TB02868F

Xiuping Wan, Caijie Zhang, Pengyu Lei, Hanbing Wang, Rongbing Chen, Qinsi Yang, Yongwei Cheng, Wei Wu, Da Sun and Xiaofei Hong

{"title":"Precision therapeutics for inflammatory bowel disease: advancing ROS-responsive nanoparticles for targeted and multifunctional drug delivery","authors":"Xiuping Wan, Caijie Zhang, Pengyu Lei, Hanbing Wang, Rongbing Chen, Qinsi Yang, Yongwei Cheng, Wei Wu, Da Sun and Xiaofei Hong","doi":"10.1039/D4TB02868F","DOIUrl":"10.1039/D4TB02868F","url":null,"abstract":"Inflammatory bowel disease (IBD) is a severe chronic intestinal disorder with a rising global incidence. Current therapies, including the delivery of anti-inflammatory drugs and probiotics, face significant challenges in terms of safety, stability, and efficacy. In IBD patients, the activity of antioxidant enzymes (e.g., superoxide dismutase, glutathione peroxidase, and glutathione reductase) is reduced at the site of intestinal inflammation, leading to the accumulation of reactive oxygen species (ROS). This accumulation damages the intestinal mucosa, disrupts tight junctions between cells, and compromises the integrity of the intestinal barrier, exacerbating IBD symptoms. Therefore, nanoparticles responsive to ROS and capable of mimicking antioxidant enzyme activity, such as boronates, polydopamine, sulfides, and metal nanozymes, have emerged as promising tools. These nanoparticles can respond to elevated ROS levels in inflamed intestinal regions and release drugs to effectively neutralize ROS, making them ideal candidates for IBD treatment. This review discusses the application of various ROS-responsive nanomaterial delivery systems in IBD therapy, highlights current challenges, and outlines future research directions. Furthermore, we explore the “layered programmable delivery” strategy, which combines ROS-responsive nanoparticles with pH-responsive and cell membrane-targeted nanoparticles. This strategy has the potential to overcome the limitations of single-mechanism targeted drug delivery, enabling multi-range and multi-functional treatment approaches that significantly enhance delivery efficiency, providing new insights for the future of localized IBD treatment.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 10","pages":" 3245-3269"},"PeriodicalIF":6.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0