Journal of Materials Chemistry B最新文献

{"title":"Correction: Galactosylated silver nanoparticles as a biocompatible intrinsic SERS probe for bladder cancer imaging and ex vivo tumor detection","authors":"Ting-Yu Cheng, Yi-Chun Chiu, Kuan-Hsu Chen, Ya-Jyun Chen and Chih-Chia Huang","doi":"10.1039/D5TB90125A","DOIUrl":"10.1039/D5TB90125A","url":null,"abstract":"<p >Correction for ‘Galactosylated silver nanoparticles as a biocompatible intrinsic SERS probe for bladder cancer imaging and <em>ex vivo</em> tumor detection’ by Ting-Yu Cheng <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2025, https://doi.org/10.1039/D5TB00546A.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11470-11470"},"PeriodicalIF":6.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90125a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimetal phenolic network-based alginate cryogels for rapid hemostasis and photothermal enhanced bimetallic chemodynamic therapy for wound infection","authors":"Zhongjia Liu, Xingkai Li, Yun Liu, Yutong Huang, Ning Guo and Xingxin Liu","doi":"10.1039/D5TB01254F","DOIUrl":"10.1039/D5TB01254F","url":null,"abstract":"<p >Fe<small>³⁺</small>-based metal-phenolic networks (MPNs) have been employed for anti-bacterial photothermal therapy (PTT) enhanced chemodynamic therapy (CDT) owing to their good photothermal properties and Fenton catalytic reactivity. However, their application in anti-bacterial therapy and wound healing was seriously limited by the lack of Fenton reaction efficiency and wound-healing-promoting capabilities. To address this challenge, we developed a sodium alginate (SA)-based cryogel (STCF) containing Fe<small>³⁺</small>/Cu<small>²⁺</small>-based bimetallic MPNs. The STCF cryogel was fabricated by co-crosslinking tannic acid (TA) and SA with both Fe<small>³⁺</small> and Cu<small>²⁺</small>, followed by lyophilization of the formed hydrogel. The integrated bimetallic MPNs could endow it with synergistic PTT/CDT. Additionally, the released Cu<small>²⁺</small> could promote angiogenesis and contribute to tissue regeneration. <em>In vitro</em> anti-bacterial assays demonstrated its synergistic bactericidal efficacy, while <em>in vivo</em> hemostasis models and infected wound model proved its good hemostatic, anti-bacterial, and wound-healing-promoting effects. Therefore, through integrating bimetallic MPNs into the STCF cryogel, our study proposed a novel strategy to explore multifunctional wound dressings for treating infected wounds, which overcomes the challenges in wound care and infection management.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11423-11438"},"PeriodicalIF":6.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SN-38-cholesterol NPs-loaded PDA NPs/agarose & pluronic F-127 hydrogel system for controlled chemo-phototherapy in tumor-localized treatment†","authors":"Zhixiang Liu, Yoshitaka Koseki, Mengheng Yang, Keita Tanita and Hitoshi Kasai","doi":"10.1039/D5TB00994D","DOIUrl":"10.1039/D5TB00994D","url":null,"abstract":"<p >Pluronic F-127 (PF-127) has low mechanical strength at low concentrations and a high gel–sol transition temperature at high concentrations, which limits its use as a controlled drug-release carrier. To address this issue while preserving the hydrogel's high biocompatibility, we developed a hydrogel system consisting of polydopamine nanoparticles (PDA NPs), agarose, and PF-127 (PDA/APF) in which agarose forms a secondary network and PDA NPs enhance hydrogen bonding in the network, thereby improving the mechanical strength and stability of the hydrogel. This modification prolonged the hydrogel's degradation period to approximately seven days and maintained gel–sol transition temperature at 59.0 °C. We incorporated SN-38-cholesterol NPs into the hydrogel system for sustained chemotherapy. Upon 808 nm near infrared (NIR) irradiation, the hydrogel system behaved as expected by releasing SN-38-cholesterol NPs through subsequent hydrogel degradation induced by the embedded PDA NPs. <em>In vivo</em> studies showed that the hydrogel system effectively inhibited tumor growth in mice following photothermal therapy with NIR light. The use of the PDA/APF hydrogel system is a promising strategy for controlled localized cancer therapy, combining chemotherapy and photothermal therapy for enhanced efficacy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 34","pages":" 10584-10599"},"PeriodicalIF":6.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00994d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Decoding tissue complexity: multiscale mapping of chemistry–structure–function relationships through advanced visualization technologies","authors":"Zhiyuan Zhao, Haijun Cui and Haitao Cui","doi":"10.1039/D5TB90124C","DOIUrl":"10.1039/D5TB90124C","url":null,"abstract":"<p >Correction for ‘Decoding tissue complexity: multiscale mapping of chemistry–structure–function relationships through advanced visualization technologies’ by Zhiyuan Zhao <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2025, <strong>13</strong>, 7897–7918, https://doi.org/10.1039/D5TB00744E.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 33","pages":" 10371-10371"},"PeriodicalIF":6.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90124c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-linked poly(alkylene citrates) with l-glutathione for vascular tissue engineering: structure–property relationships and cell-type dependent response to oxidative stress†","authors":"Filip Koper, Dominika Grzywna, Lucie Svobodová, Antonín Sedlář, Libor Kobera, Tomáš Riedel, Zuzana Riedelová, Agata Flis, Hynek Beneš, Elżbieta Pamuła, Lucie Bačáková and Wiktor P. Kasprzyk","doi":"10.1039/D4TB02563F","DOIUrl":"10.1039/D4TB02563F","url":null,"abstract":"<p >Cross-linked poly(alkylene citates) (cPAC) based on 1,6-hexanediol (cPHC) and 1,8-octanediol (cPOC) and modified with 0.4, 0.8 and 1.6% w/w <small>L</small>-glutathione (GSH) were synthesized as potential materials for vascular tissue engineering. The materials prepared at a citric acid : diol molar ratio of 2 : 3 exhibited superior mechanical strength and reduced acidity in comparison to the 1 : 1 materials. All materials exhibited blue fluorescence, which intensity was enhanced with increasing GSH concentration. Conversely, the latter demonstrated marginally enhanced antioxidant properties. The preliminary cell culture tests of the 2 : 3 materials with human adipose tissue stem cells (ASCs) revealed that cPOC did not provide an appropriate environment for cell colonization due to its higher acidity than cPHC. In contrast, cPHC promoted the growth of ASCs and other cell types, including fibroblasts (NHDFs), endothelial cells (HUVECs), and smooth muscle cells (SMCs), at all GSH concentrations, with minimal negative effect on HUVEC and SMC proliferation. The induction of oxidative stress by menadione demonstrated a notable decline in the metabolic activity of both ASCs and NHDFs on cPHCs across all GSH concentrations. However, an incremental protective effect on the cells was observed with increasing GSH concentrations. In contrast, HUVECs and SMCs demonstrated increased metabolic activity, without the protective effect of GSH being observed. Therefore, the findings demonstrate that cell type-specific differences exist in cell response to oxidative stress. Consequently, the addition of antioxidants to the polymer should be guided by the intended cell type for use in vascular reconstruction. Our results also suggest an intrinsic antioxidant activity of cPHC materials and their good hemocompatibility with human blood <em>in vitro</em>.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 34","pages":" 10552-10575"},"PeriodicalIF":6.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02563f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced mRNA and pDNA delivery via PEGylated solid lipid nanoparticles with an optimally balanced ionizable/cationic lipid content","authors":"Nipuni Maniyamgama, Ki Hyun Bae, Jialing Lee, James Hoi Po Hui and Yi Yan Yang","doi":"10.1039/D5TB00470E","DOIUrl":"10.1039/D5TB00470E","url":null,"abstract":"<p >Non-viral gene delivery holds significant promise for the treatment of various diseases. Solid lipid nanoparticles (SLNs) are emerging as promising gene delivery vehicles due to their ease of manufacture and high stability. However, the development of efficient and safe SLNs remains a challenge. This study aims to develop ionizable lipid-incorporated PEGylated SLNs (PEG-iSLNs) for effective mRNA and plasmid DNA (pDNA) delivery. Using a solvent emulsification/evaporation technique, a series of PEG-iSLNs were formulated at various weight ratios of the ionizable lipid ALC-0315 to the cationic lipid DOTMA. PEG-iSLNs formulated at an optimal ALC-0315/DOTMA ratio had superior mRNA transfection potency and membrane fusion activity over those with either ALC-0315 or DOTMA alone. iSLNs and PEG-iSLNs appeared to remain stable during storage at 4 °C over 18 and 12 months, respectively. Bioluminescence imaging study demonstrated the feasibility of the top-performing candidate, PEG-iSLN-3, for <em>in vivo</em> delivery of mRNA <em>via</em> both intramuscular and footpad subcutaneous routes, highlighting its potential as an efficient and nontoxic delivery vehicle for diverse nucleic acid cargoes.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 12172-12184"},"PeriodicalIF":6.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00470e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbonised porous silicon as scaffold and sensor for the electrochemical detection and characterisation of bacterial biofilm growth","authors":"Fearghal O’Connor, Alexandros Lazanas and Beatriz Prieto Simón","doi":"10.1039/D5TB01036E","DOIUrl":"10.1039/D5TB01036E","url":null,"abstract":"<p >The use of carbonised porous silicon (C-pSi) substrates as both scaffolds and electrodes for the electrochemical detection and characterisation of bacterial biofilm growth is reported for the first time. Three types of C-pSi are presented showcasing versatility in their hydrophilicity and surface chemistry. The tunability of these properties is taken as a springboard for the biological, morphological and electrochemical evaluation of the biofilms. The combined characterisation data obtained from environmental scanning electron microscopy, confocal scanning laser microscopy, cyclic voltammetry and electrochemical impedance spectroscopy, confirm C-pSi as a powerful tool for sensing bacterial biofilm growth. The collective assessment of biofilm growth at the C-pSi surface reveals changes related both to morphological and temporal parameters.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11284-11297"},"PeriodicalIF":6.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01036e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiogenesis gene signatures in patient-derived tumor spheroids for genetic and tumor angiogenesis profiling†","authors":"Sujin Hyung, Jihoon Ko, Minae An, Seung Tae Kim, Se Hoon Park, Jung Yong Hong, Sung Hee Lim, Kyoung-Mee Kim and Jeeyun Lee","doi":"10.1039/D5TB00577A","DOIUrl":"10.1039/D5TB00577A","url":null,"abstract":"<p > <em>Background</em>: gastric cancers are highly vascular tumors, with elevated pro-angiogenic factors correlating with a poor prognosis. Despite advancements in precision medicine, there remains a critical need for platforms capable of identifying patient-specific therapeutic vulnerabilities. In this study, we present a 3D-printed patient-specific tumor angiogenesis chip that integrates genetic data to evaluate the molecular and functional characteristics of tumor angiogenesis in tumor spheroids derived from patients with gastric cancer. <em>Results</em>: whole-transcriptome analysis classified tumor spheroids into high- and low-angiogenesis-related gene signatures groups. Tumors with high angiogenesis-related gene signatures exhibited significantly enhanced blood vessel formation and tumor growth on the 3D tumor angiogenesis chips compared to those with low gene signatures [vessel density: 1.091 <em>vs.</em> 0.7538; vessel length: 1.070 <em>vs.</em> 0.8344; and angiogenic sprouting number: 1.184 <em>vs.</em> 0.6541]. The platform also enabled quantitative drug response assessments, providing a robust framework for evaluating treatment efficacy. <em>Conclusion</em>: these 3D-printed tumor angiogenesis chips, leveraging genomic profiling and patient-specific tumor characteristics, offer a powerful tool for advancing personalized medicine in gastric cancer.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11597-11610"},"PeriodicalIF":6.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intercalating cerium into layered double hydroxide as a promising reactive oxygen species scavenger for inflammation treatment","authors":"Thanh-Truc Nguyen, Gábor Varga, Jessica Pickett, Miaomiao Wu, Hang Thu Ta, Zhi Ping Xu and Run Zhang","doi":"10.1039/D5TB00829H","DOIUrl":"10.1039/D5TB00829H","url":null,"abstract":"<p >Nanoceria has been studies for many decades given its capability in quenching reactive oxygen species (ROS) in inflammatory diseases. The regenerative exchanges between Ce<small>³⁺</small> and Ce<small>⁴⁺</small> as well as the ratio between these two cations have been reported as one of the most important factors for enhancing their ROS scavenging activity. In this study, a novel method for increasing the active sites and the ratio of Ce<small>³⁺</small>/Ce<small>⁴⁺</small> utilising layered double hydroxides (LDH) nano system has been developed. Ce doped LDH nanoparticles with various Ce-loading amounts were prepared, and the physicochemical properties were characterised. The anti-hydrogen peroxide (H<small>₂</small>O<small>₂</small>) capability of these Ce–LDH NPs has been evaluated <em>in vitro</em> against the treated RAW 264.7 macrophages. The optimal Ce–LDH NPs were then introduced into a 3D cell-hydrogel construct resembling the pathological morphology of atherosclerosis to investigate their ability to capture ROS in a more complex cell system. The successful development of this Ce-doped LDH nanosystem provides a promising biocompatible agent for future treatment of inflammatory disorders.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 11001-11009"},"PeriodicalIF":6.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of flexible and stable β-glycine/polyvinyl alcohol nanofibers with unidirectional polarization orientation via electrospinning†","authors":"Han Qiu, Hezhi He, Yiming Zhang, Mohong Xu, He Zhang and Zhiwen Zhu","doi":"10.1039/D5TB01098E","DOIUrl":"10.1039/D5TB01098E","url":null,"abstract":"<p >Piezoelectric biomaterials have emerged as highly desirable candidates for biomedical applications, owing to their non-toxicity, biocompatibility, and biodegradability, distinguishing them from ceramic and polymer alternatives. However, the primary challenge in the development of piezoelectric biomaterials lies in the absence of effective and convenient methods to attain unidirectional polarization alignment. Here, we report that a β-glycine/polyvinyl alcohol (PVA) nanofiber film with unidirectional polarization orientation was prepared <em>via</em> a simple electrospinning method, and a superior piezoelectric coefficient of 12.7 ± 1.4 pC N<small>⁻¹</small> was achieved. More importantly, the presence of PVA not only endows the β-glycine nanocrystals confined within PVA nanofibers with outstanding temporal and thermal stability but also imparts flexibility to the β-glycine/PVA nanofiber film. This study provides guidance for the construction of flexible and stable piezoelectric biomaterials with unidirectional polarization orientation, facilitating their biomedical applications in the future.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 34","pages":" 10543-10551"},"PeriodicalIF":6.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}