Journal of Materials Chemistry B最新文献_第8页

Expression of concern: Selective isolation and eradication of E. coli associated with urinary tract infections using anti-fimbrial modified magnetic reduced graphene oxide nanoheaters 关注表达：使用抗毛毡改性磁性还原氧化石墨烯纳米加热器选择性分离和根除与尿路感染相关的大肠杆菌。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90186J

Fatima Halouane, Roxana Jijie, Dalila Meziane, Chengnan Li, Santosh K. Singh, Julie Bouckaert, Jean Jurazek, Sreekumar Kurungot, Alexandre Barras, Musen Li, Rabah Boukherroub and Sabine Szunerits

引用次数: 0

Expression of concern: Particle-based photodynamic therapy based on indocyanine green modified plasmonic nanostructures for inactivation of a Crohn's disease-associated Escherichia coli strain 关注表达：基于吲哚菁绿修饰等离子体纳米结构的颗粒光动力疗法用于克罗恩病相关大肠杆菌菌株的失活。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90194K

Roxana Jijie, Tetiana Dumych, Li Chengnan, Julie Bouckaert, Kostiantyn Turcheniuk, Charles-Henri Hage, Laurent Heliot, Benoit Cudennec, Nicoleta Dumitrascu, Rabah Boukherroub and Sabine Szunerits

引用次数: 0

Multiple aptamer recognition-based quantum dot lateral flow platform: ultrasensitive point-of-care testing of respiratory infectious diseases† 基于多种适配体识别的量子点横向流动平台：呼吸道传染病的超灵敏床旁检测。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB01946F

Hengxuan Li, Xiaoyi Fu, Qimin You, Dawei Shi, Lingxuan Su, Minghui Song, Ruizi Peng, Ting Fu, Peng Wang and Weihong Tan

{"title":"Multiple aptamer recognition-based quantum dot lateral flow platform: ultrasensitive point-of-care testing of respiratory infectious diseases†","authors":"Hengxuan Li, Xiaoyi Fu, Qimin You, Dawei Shi, Lingxuan Su, Minghui Song, Ruizi Peng, Ting Fu, Peng Wang and Weihong Tan","doi":"10.1039/D4TB01946F","DOIUrl":"10.1039/D4TB01946F","url":null,"abstract":"Respiratory infectious diseases spread rapidly and have a wide range of impacts, posing a serious threat to public health security. The development of a sensitive, accurate, and rapid detection method for respiratory viruses is crucial for disease prevention and control. However, existing methods are inadequate in satisfying the demand for accurate and convenient detection simultaneously. Therefore, an ultrasensitive point-of-care testing (POCT) platform based on a multiple aptamer recognition-based quantum dot lateral flow immunoassay (MARQ-LFIA) was developed in this work. This platform consisted of multiple high-affinity aptamers for recognizing different sites on a respiratory infectious virus protein, enhancing the efficiency of virus identification in complex environments. By combining a multiple aptamer recognition strategy with quantum dot fluorescent technique to construct LFIA test strips and pairing them with a high-gain portable fluorescence reader, excellent detection sensitivity and specificity were achieved in the case of coronavirus disease 2019 (COVID-19). The limits of detection were 1.427 pg mL−1 and 1643 U mL−1 towards the nucleocapsid protein and inactivated viruses, respectively, indicating that MARQ-LFIA improved detection sensitivity compared to reported methods. More critically, by testing thirty COVID-19 positive and twenty negative patient samples, the positive detection rate increased from 55.17% to 86.67% compared with commercially similar products. The universality of MARQ-LFIA was also investigated for diagnosing influenza B. We believe that MARQ-LFIA can be a promising POCT tool with potential applications in the areas of public health for the growing demand for precision diagnosis and treatment.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 5","pages":" 1681-1689"},"PeriodicalIF":6.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroinflammation-targeted magnetic resonance imaging nanoprobes for the early diagnosis of Alzheimer's disease† 用于阿尔茨海默病早期诊断的神经炎症靶向磁共振成像纳米探针。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB02210F

Yanjiao Jiang, Wenyue Li, Yuqiang Ma and Yi Hou

{"title":"Neuroinflammation-targeted magnetic resonance imaging nanoprobes for the early diagnosis of Alzheimer's disease†","authors":"Yanjiao Jiang, Wenyue Li, Yuqiang Ma and Yi Hou","doi":"10.1039/D4TB02210F","DOIUrl":"10.1039/D4TB02210F","url":null,"abstract":"Alzheimer's disease (AD) that is an important contributor to dementia, is a chronic and irreversible neurodegenerative disease, with high rates of disability and mortality. Recently, more and more therapeutic methods have been developed to delay the progression of AD, but it remains a great challenge to achieve the early diagnosis of AD. In this work, we developed a magnetic resonance imaging (MRI) nanoprobe (NP@angiopep-2/CD137) based on angiopep-2 peptide and CD137 antibody with a NaGdF4 nanoparticle as the core and realized neuroinflammation-targeted imaging on APP/PS1 model mice using a clinical 7.0 T MRI scanner. CD137 expression was upregulated in neuroglial cells and cerebral vascular endothelial cells in inflammatory state. In the APP/PS1 mouse model, after administration, the nanoprobe-enhanced images showed specific dot-like signals in the susceptibility-weighted imaging (SWI) sequence. In summary, we designed and synthesized NP@angiopep-2/CD137 nanoprobes using the activation-dependent expression of CD137, which were applied to the pathological assessment of AD based on the hypothesis of AD neuroinflammation, and provided a reliable idea for the early molecular imaging diagnosis of AD.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 4","pages":" 1424-1436"},"PeriodicalIF":6.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to targeted biomedical applications of nanomaterials 纳米材料在生物医学上的应用简介。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90187H

Dhiraj Bhatia, Mukesh Dhanka, Anjali Awasthi, Kamlendra Awasthi and Kaushik Chatterjee

引用次数: 0

Expression of concern: Plasmonic photothermal destruction of uropathogenic E. coli with reduced graphene oxide and core/shell nanocomposites of gold nanorods/reduced graphene oxide 关注表达：用还原氧化石墨烯和金纳米棒/还原氧化石墨烯的核/壳纳米复合材料对尿路致病性大肠杆菌的等离子光热破坏。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB90184C

Kostiantyn Turcheniuk, Charles-Henri Hage, Jolanda Spadavecchia, Aritz Yanguas Serrano, Iban Larroulet, Amaia Pesquera, Amaia Zurutuza, Mariano Gonzalez Pisfil, Laurent Héliot, Julie Boukaert, Rabah Boukherroub and Sabine Szunerits

引用次数: 0

Progress in the treatment of Alzheimer's disease based on nanosized traditional Chinese medicines 纳米中药治疗阿尔茨海默病的研究进展。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-05 DOI: 10.1039/D4TB02062F

Dan Song, Jieyu Zhang, Xuefeng Hu and Xiaoyan Liu

引用次数: 0

Progress in Chinese medicine monomers and their nanoformulations on myocardial ischemia/reperfusion injury 中药单体及其纳米制剂对心肌缺血再灌注损伤的研究进展。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-04 DOI: 10.1039/D4TB02091J

Yanrong Zhou, Li Wang, Lina Sun, Rui Tan, Zheng Wang and Renjun Pei

{"title":"Progress in Chinese medicine monomers and their nanoformulations on myocardial ischemia/reperfusion injury","authors":"Yanrong Zhou, Li Wang, Lina Sun, Rui Tan, Zheng Wang and Renjun Pei","doi":"10.1039/D4TB02091J","DOIUrl":"10.1039/D4TB02091J","url":null,"abstract":"Myocardial ischemia/reperfusion injury (MIRI) is the entire process of myocardial injury resulting from ischemia and hypoxia following acute myocardial infarction, which involves complicated pathogenesis including energy metabolism disorders, calcium overload, oxidative stress and mitochondrial dysfunction. Traditional Chinese medicine (TCM) has attracted intensive attention in the treatment of MIRI owing to its multitarget therapeutic effects and low systemic toxicity. Increasing evidence indicates the promising application of TCM on the protection of cardiomyocytes, improvement of endothelial cell functions and regulation of energy metabolism and inflammatory response. Although the efficacy of TCM has been well-proven, the underlying mechanisms remain unclear. Additionally, the clinical application of much TCM had been hampered due to its low aqueous solubility, poor gastrointestinal absorption, and decreased bioavailability. In this review, we examined the pathological mechanism of MIRI and highlighted recent research studies on the therapeutic effects and molecular mechanisms of monomer compounds derived from TCM. We also summarized the latest studies in nanoformulation-based strategies for improving the targeting and stability of TCM monomers and exerting synergistic effects. The aim of this study was to provide a scientific basis for the treatment of MIRI with TCM monomers combined with nanomaterials, revealing their clinical significance and development prospects.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 4","pages":" 1159-1179"},"PeriodicalIF":6.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 vaccine based on ferritin complexes with screened immunogenic sequences from the Fv-antibody library 基于从fv抗体文库中筛选的免疫原性序列的铁蛋白复合物的SARS-CoV-2疫苗。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-04 DOI: 10.1039/D4TB01595A

Jaeyong Jung, Tae-Hun Kim, Jae-Yeon Park, Soonil Kwon, Jeong Soo Sung, Min-Jung Kang, Joachim Jose, Misu Lee, Hyun-Jin Shin and Jae-Chul Pyun

{"title":"SARS-CoV-2 vaccine based on ferritin complexes with screened immunogenic sequences from the Fv-antibody library","authors":"Jaeyong Jung, Tae-Hun Kim, Jae-Yeon Park, Soonil Kwon, Jeong Soo Sung, Min-Jung Kang, Joachim Jose, Misu Lee, Hyun-Jin Shin and Jae-Chul Pyun","doi":"10.1039/D4TB01595A","DOIUrl":"10.1039/D4TB01595A","url":null,"abstract":"In this study, the vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was developed using ferritin complexes with the immunogenic sequences screened against the SARS-CoV-2 spike protein (SP) from the Fv-antibody library. The Fv-antibody library was prepared on the outer membrane of E. coli by the expression of the VH region of immunoglobulin G (IgG) with a randomized complementarity-determining region 3 (CDR3). Four Fv-antibodies to the receptor-binding domain (RBD) were screened from the Fv-antibody library, which had a comparable binding constant (KD) between SARS-CoV-2 SP and the angiotensin-converting enzyme 2 (ACE2) receptor. The binding sites of screened Fv-antibodies on the RBD were analyzed using a docking analysis, and these binding sites were used as immunogenic sequences for the vaccine. The four immunogenic sequences were modified and co-expressed as a part of ferritin which was assembled into a ferritin complex. After the vaccination of ferritin complexes to mice, the anti-sera were analyzed to have a high enough titer. Additionally, the immune responses were found to be activated by vaccination, such as the expression of IgG subclasses and the increased level of cytokines. The neutralizing activity of the anti-sera was estimated using a cell-based infection assay based on pseudo-virus expressing the SP of SARS-CoV-2 variants.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 4","pages":" 1383-1394"},"PeriodicalIF":6.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and application of hydrogels in pathogenic bacteria detection in foods 开发水凝胶并将其应用于食品中致病菌的检测。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-12-04 DOI: 10.1039/D4TB01341G

Shuxiang Liu, Md Rashidur Rahman, Hejun Wu, Wen Qin, Yanying Wang and Gehong Su

{"title":"Development and application of hydrogels in pathogenic bacteria detection in foods","authors":"Shuxiang Liu, Md Rashidur Rahman, Hejun Wu, Wen Qin, Yanying Wang and Gehong Su","doi":"10.1039/D4TB01341G","DOIUrl":"10.1039/D4TB01341G","url":null,"abstract":"Hydrogels are 3D networks of water-swollen hydrophilic polymers. It possesses unique properties (e.g., carrying biorecognition elements and creating a micro-environment) that make it highly suitable for bacteria detection (e.g., expedited and effective bacteria detection) and mitigation of bacterial contamination in specific environments (e.g., food systems). This study first introduces the materials used to create hydrogels for bacteria detection and the mechanisms for detection. We also summarize different hydrogel-based detection methods that rely on external stimuli and biorecognition elements, such as enzymes, temperature, pH, antibodies, and oligonucleotides. Subsequently, a range of widely utilized bacterial detection technologies were discussed where recently hydrogels are being used. These modifications allow for precise, real-time diagnostics across varied food matrices, responding effectively to industry needs for sensitivity, scalability, and portability. After highlighting the utilization of hydrogels and their role in these detection techniques, we outline limitations and advancements in the methods for the detection of foodborne pathogenic bacteria, especially the potential application of hydrogels in the food industry.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 4","pages":" 1229-1251"},"PeriodicalIF":6.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0