Journal of Materials Chemistry B最新文献

{"title":"Multifunctional hydroxyquinoline-derived turn-on fluorescent probe for Alzheimer's disease detection and therapy†","authors":"Priyam Ghosh, Sayantani Mukhopadhyay, Thirukumaran Kandasamy, Subrata Mondal, Siddhartha Sankar Ghosh and Parameswar Krishnan Iyer","doi":"10.1039/D4TB01740D","DOIUrl":"10.1039/D4TB01740D","url":null,"abstract":"<p >Understanding molecular motifs that can interfere with amyloid fibrillation through non-covalent interactions is essential for addressing abnormal protein aggregation and associated human diseases. The pursuit of efficient diagnostic and treatment approaches for Alzheimer's disease (AD) has resulted in the development of M8HQ, a multifaceted small molecule turn-on probe derived from 8-hydroxyquinoline with versatile capabilities. M8HQ shows a strong affinity for amyloid beta (Aβ) fibrils, and its ability to target lysosomes enhances therapeutic precision by localizing within these organelles. This localization is essential for restoring cellular balance and maintaining LAMP1 expression, both of which are crucial for addressing AD. It also displays the ability to disaggregate Aβ fibrils and inhibit their formation, thus addressing therapeutic processes in AD progression. M8HQ further blocks reactive oxygen species (ROS)-mediated apoptosis, providing neuroprotective effects. Additionally, it chelates metal ions like Cu(<small>II</small>) and Fe(<small>III</small>), mitigating metal-induced aggregation and oxidative stress. Molecular docking and simulation studies have elucidated the interactions between M8HQ and Aβ, confirming its binding efficacy and stability. These combined properties highlight M8HQ's potential as a comprehensive diagnostic and therapeutic tool for AD.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 4","pages":" 1412-1423"},"PeriodicalIF":6.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional NO supramolecular nanomedicine for thrombus risk reduction and intimal hyperplasia inhibition†","authors":"Kuangshi Zhou, Chengchen Huang, Jian Li, Wenbin Dai, Zhaoyang Lu, Fan Jia, Qiao Jin, Min Shang, Jian Ji and Guosheng Fu","doi":"10.1039/D4TB02271H","DOIUrl":"10.1039/D4TB02271H","url":null,"abstract":"<p >Cardiovascular diseases (CVDs) are the foremost cause of mortality worldwide, with incidence and mortality rates persistently climbing despite extensive research efforts. Innovative therapeutic approaches are still needed to extend patients’ lives and preserve their health. In the present study, novel supramolecular nanomedicine with both nitric oxide (NO) and antioxidant releasing ability was developed to enhance therapeutic efficacy against vascular injuries. Utilizing α-cyclodextrin (α-CD) as a host molecule, the nanomedicine aims to achieve site-specific delivery <em>via</em> targeting peptide rendered selective accumulation. By scavenging ROS and amplifying NO's regulatory effects, the nanomedicine readily restored vascular homeostasis, in both acute and chronic CVDs. It served as a promising solution to overcome the challenges associated with NO-based therapies and may inspire future research studies on new therapies for CVDs.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 5","pages":" 1811-1822"},"PeriodicalIF":6.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced liquid–liquid phase separation of stress granules in a reconstructed model and their cytoplasmic targeting using a DNA nanodevice†","authors":"Yue Liao, Chunyu Fan, Jiaxin Zheng, Caixia Liu, Weiping Zhu, Yufang Xu, Xuhong Qian and Yangyang Yang","doi":"10.1039/D4TB02161D","DOIUrl":"10.1039/D4TB02161D","url":null,"abstract":"<p >Biomolecular condensates (BCs) are crucial membraneless organelles formed through the process of liquid–liquid phase separation (LLPS) involving proteins and nucleic acids. These LLPS processes are tightly linked with essential cellular activities. Stress granules (SGs), functioning as cytoplasmic BCs, play indispensable roles in maintaining cellular homeostasis and are implicated in diseases like cancers and neurodegenerative disorders. However, devices that can regulate SG LLPS are lacking. Herein, a triangular prism-shaped DNA nanostructure containing polythymidine (ΔDNA<small>_(polyT)</small>) is presented as a nanodevice to investigate the LLPS process of <em>in vitro</em> reconstructed SGs (rSGs), a mixture of marker protein G3BP1 and total RNAs. Our observations reveal that the concentration threshold required for rSG LLPS decreases upon addition of ΔDNA<small>_(polyT)</small>, suggesting an enhancement in SG LLPS efficiency. It is speculated that ΔDNA<small>_(polyT)</small> can concentrate mRNAs onto its surface <em>via</em> polyT hybridization with poly-adenosine sequences (polyA) in mRNAs. This alteration in the spatial distribution of mRNAs subsequently affects the multivalency interactions between G3BP1 and mRNAs. Furthermore, ΔDNA<small>_(polyT)</small> exhibits excellent colocalization with cytoplasmic SGs under stressed conditions. This DNA-based nanodevice presents a new artificial approach for the targeted regulation of BC LLPS and holds promise for future studies focusing on BCs.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 5","pages":" 1744-1752"},"PeriodicalIF":6.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced surface hydrophilicity improves osseointegration of titanium implants via integrin-mediated osteoimmunomodulation†","authors":"Zheng Zheng, Shuaiqi Gan, Shuhan Yang, Chuping Hou, Zhimin Zhu, Hang Wang, Deping Yu, Zhiyong Qian, Hockin H. K. Xu and Wenchuan Chen","doi":"10.1039/D4TB02360A","DOIUrl":"10.1039/D4TB02360A","url":null,"abstract":"<p >Titanium (Ti) implants have become widespread especially in dentistry and orthopedics, where macrophage-driven osteoimmunomodulation is crucial to their success. Hydrophilic modification of Ti represents a promising strategy to enhance its immune and osteogenic responses. Herein, the osteoimmunomodulatory performance and integrin-mediated mechanism of novel non-thermal atmospheric plasma (NTAP) treatment to induce a hydrophilic Ti were investigated for the first time. Compared to a hydrophobic surface, NTAP-modified Ti possessed a 3-fold increase of pro-healing M2 macrophage makers, and the doubled osteogenic differentiation of mesenchymal stem cells was demonstrated in this immune microenvironment, thus improving early osseointegration. Mechanistically, the ameliorative osteoimmunomodulatory properties of NTAP were attributed to its positive and negative modulation in macrophages’ integrin β1 or β2, and the subsequent FAK-PI3K/Akt or NF-κB signaling pathway. Collectively, this study highlighted the role of integrins and related signaling pathways in hydrophilic implant-caused macrophage polarization, therefore inventively unveiling the underlying mechanism of NTAP-enhanced osteoimmunomodulation. Furthermore, it established a robust theoretical foundation for the clinical application of this cost-effective, versatile, and transformation-valuable surface engineering strategy for the development of next-generation Ti implants.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 2","pages":" 496-510"},"PeriodicalIF":6.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled peptide-based nanofibers for cardiovascular tissue regeneration","authors":"Dhriti Shenoy, Sowmya Chivukula, Nursu Erdogan, Enrica Chiesa, Sara Pellegrino, Meital Reches and Ida Genta","doi":"10.1039/D4TB01235F","DOIUrl":"10.1039/D4TB01235F","url":null,"abstract":"<p >Cardiovascular diseases are the leading cause of death worldwide, claiming millions of lives every year. Cardiac tissue engineering has emerged as a versatile option for repairing cardiac tissue and helping its regeneration. The use of nanomaterials, particularly nanofiber-based scaffolds combined with biomolecular cues like peptides, has significantly improved the compatibility and efficacy of the scaffolds for cardiac tissue regeneration. By utilising the self-assembly properties of peptides to create nanofiber scaffolds, we can achieve stability that closely mimics the natural components of cardiac tissue, making them perfect for cardiac tissue regeneration. In this review, we highlighted the dynamic process of self-assembly into nanofibers and the use of various self-assembled nanofibers for cardiovascular tissue regeneration, focusing on their roles in antithrombotic, angiogenic, differentiation, proliferation, and anti-atherosclerotic interventions.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 3","pages":" 844-857"},"PeriodicalIF":6.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb01235f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New thermoplastic poly(ester–ether) elastomers with enhanced mechanical properties derived from long-chain dicarboxylic acid for medical device applications†","authors":"Xiangwei Wu, Tao Yang, Xiaoqin Jiang, Wei Su, Fei Liu, Jinggang Wang and Jin Zhu","doi":"10.1039/D4TB02183E","DOIUrl":"10.1039/D4TB02183E","url":null,"abstract":"<p >Recent advances in medical plastics highlight the need for sustainable materials with desirable elastic properties. Traditional polyester elastomers have been used as alternatives to polyvinyl chloride (PVC) due to their biocompatibility and adjustable mechanical properties. However, these materials often lack the necessary stability and toughness for reliable medical applications. To address these issues, this study introduces renewable 1,12-dodecanedioic acid (DA) to create a copolymer with diols, resulting in a structure akin to polyolefins. This innovative approach significantly enhances toughness by regulating chain segment lengths and integrates high performance with sustainability. The resulting bio-based elastomer exhibits remarkable biocompatibility and elastic recovery (69.0%). This work represents a significant advancement in the development of eco-friendly materials suitable for medical device applications, with potential implications for tissue engineering and other healthcare technologies.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 5","pages":" 1731-1743"},"PeriodicalIF":6.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress towards the development of fluorescent probes for the detection of disease-related enzymes","authors":"Lopamudra Mishra and Monalisa Mishra","doi":"10.1039/D4TB01960A","DOIUrl":"10.1039/D4TB01960A","url":null,"abstract":"<p >Normal physiological functions as well as regulatory mechanisms for various pathological conditions depend on the activity of enzymes. Thus, determining the <em>in vivo</em> activity of enzymes is crucial for monitoring the physiological metabolism and diagnosis of diseases. Traditional enzyme detection methods are inefficient for <em>in vivo</em> detection, which have different limitations, such as high cost, laborious, and inevitable invasive procedures, low spatio-temporal resolution, weak anti-interference ability, and restricted scope of application. Because of its non-destructive nature, ultra-environmental sensitivity, and high spatiotemporal resolution, fluorescence imaging technology has emerged as a potent tool for the real-time visualization of live cells, thereby imaging the motility of proteins and intracellular signalling networks in tissues and cells and evaluating the binding and attraction of molecules. In the last few years, significant advancements have been achieved in detecting and imaging enzymes in biological systems. In this regard, the high sensitivity and unparalleled spatiotemporal resolution of fluorescent probes in association with confocal microscopy have garnered significant interest. In this review, we focus on providing a concise summary of the latest developments in the design of fluorogenic probes used for monitoring disease-associated enzymes and their application in biological imaging. We anticipate that this study will attract considerable attention among researchers in the relevant field, encouraging them to pursue advances in the development and application of fluorescent probes for the real-time monitoring of enzyme activity in live cells and <em>in vivo</em> models while ensuring excellent biocompatibility.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 3","pages":" 763-801"},"PeriodicalIF":6.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodegradable polyacrylamide tanglemers enable spatiotemporal control over chain lengthening in high-strength and low-hysteresis hydrogels†","authors":"Joshua S. Lee, Bruce E. Kirkpatrick, Abhishek P. Dhand, Lea Pearl Hibbard, Benjamin R. Nelson, Nathaniel P. Skillin, Makayla C. Johnson, Dilara Batan, Benjamin D. Fairbanks, Timothy J. White, Christopher N. Bowman, Jason A. Burdick and Kristi S. Anseth","doi":"10.1039/D4TB02149E","DOIUrl":"10.1039/D4TB02149E","url":null,"abstract":"<p >Covalent hydrogel networks suffer from a stiffness-toughness conflict, where increased crosslinking density enhances the modulus of the material but also leads to embrittlement and diminished extensibility. Recently, strategies have been developed to form highly entangled hydrogels, colloquially referred to as tanglemers, by optimizing polymerization conditions to maximize the density and length of polymer chains and minimize the crosslinker concentration. It is challenging to assess entanglements in crosslinked networks beyond approximating their theoretical contribution to mechanical properties; thus, in this work, we synthesize and characterize polyacrylamide tanglemers using a photolabile crosslinker, which allows for direct assessment of covalent trapping of entanglements under tension. Further, this chemistry allows tuning of the modulus <em>in situ</em> by crosslink photocleavage (from tensile modulus (<em>E</em><small>_T</small>) = 100 kPa to &lt;25 kPa). Beyond cleavage of crosslinks, we demonstrate that even non-degradable tanglemer formulations can be photo-softened and completely degraded through Fe<small>³⁺</small>-mediated oxidation of the polyacrylamide backbone. While both photodegradation methods are useful for spatial patterning and result in softer gels with reduced fracture strength, only crosslink photocleavage improves gel extensibility <em>via</em> light-induced chain lengthening (<em>ε</em><small>_F</small> = 700% to &gt;1500%). Crosslink photocleavage in tanglemers also affords significant control over localized swelling and diffusivity. In sum, we introduce a simple and user-directed approach for probing entanglements and asserting spatiotemporal control over stress–strain responses and small molecule diffusivity in polyacrylamide tanglemers, suggesting a multitude of potential soft matter applications including controlled release and tunable bioadhesive interfaces.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 3","pages":" 894-903"},"PeriodicalIF":6.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: Reduced graphene oxide nanosheets decorated with AuPd bimetallic nanoparticles: a multifunctional material for photothermal therapy of cancer cells","authors":"Gitashree Darabdhara, Manash R. Das, Volodymyr Turcheniuk, Kostiantyn Turcheniuk, Vladimir Zaitsev, Rabah Boukherroub and Sabine Szunerits","doi":"10.1039/D4TB90185A","DOIUrl":"10.1039/D4TB90185A","url":null,"abstract":"<p >Expression of concern for ‘Reduced graphene oxide nanosheets decorated with AuPd bimetallic nanoparticles: a multifunctional material for photothermal therapy of cancer cells’ by Gitashree Darabdhara <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2015, <strong>3</strong>, 8366–8374, https://doi.org/10.1039/C5TB01704A.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 1","pages":" 355-355"},"PeriodicalIF":6.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb90185a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation†","authors":"Leigh Naylor-Adamson, Thomas W. Price, Zoe Booth, Sophie V. L. Leonard, Juan Gallo, Le Duc Tung, Stanley Harvell-Smith, Nguyen Thi Kim Thanh, Zabeada Aslam, David Allsup, Nicole Hondow, Thomas Chamberlain, Jürgen E. Schneider, Khalid Naseem, Jean-Sebastien G. Bouillard, Graeme J. Stasiuk and Simon D. J. Calaminus","doi":"10.1039/D4TB01334D","DOIUrl":"10.1039/D4TB01334D","url":null,"abstract":"<p >Quantum dots (QDs) are semiconducting inorganic nanocrystals, that have garnered interest in biological and medical spheres due, to their potential benefits in biomedical imaging and drug-delivery systems. Indium phosphide QDs shelled with zinc sulphide (InP/ZnS) are viewed as more biocompatible than previous heavy metal based QDs. However, little is known about how InP/ZnS QDs affect a key blood cell, the platelet. Understanding how platelets interact with QDs is critical as unwanted activation can lead to pathological thrombus formation. Herein, we demonstrate PEGylation of InP/ZnS QDs coated with lipoic acid (QD-LA) or coated with penicillamine (QD-Pen) surface ligands induced markedly less platelet aggregation, platelet–QD interactions, integrin activation, alpha granule secretion and restored platelet spreading in washed platelets in comparison to their non-PEGylated counterparts. Furthermore, in whole blood, PEGylation of QDs reduced the number of QDs in the thrombus, thereby helping to minimise the chance of dysfunctional thrombus formation. Overall, we show that QD PEGylation is important to help prevent QD mediated platelet activation. In combination with the most biocompatible coating, PEGylation markedly reduced platelet activation, widening the concentrations at which QDs were viable for development as potential drug delivery or imaging agents.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 3","pages":" 1052-1063"},"PeriodicalIF":6.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}