Journal of Materials Chemistry B最新文献

{"title":"Dual-responsive polydopamine-embellished Zn-MOFs enabling synergistic photothermal and antibacterial metal ion therapy for oral biofilm eradication†","authors":"Ge Pan, Jinyao Zheng, Zongjia Li, Qian Duan, Miaomiao Zhang and Dapeng Wang","doi":"10.1039/D4TB02427C","DOIUrl":"10.1039/D4TB02427C","url":null,"abstract":"<p >Oral biofilms are associated with various oral diseases causing pain and discomfort, and pose a severe threat to general health. Conventional surgical debridement and antibacterial therapy often yield unsatisfactory outcomes because they either fail to fully and painlessly eliminate biofilms or increase the risk of bacterial resistance. In this study, we synthesized polydopamine-embellished Zn-MOFs (ZIF-8@PDA NPs), which can degrade under mildly acidic conditions to release Zn<small>²⁺</small>. These nanoparticles also convert near-infrared light energy into heat, thereby enabling synergistic photothermal and antibacterial metal ion therapy for oral biofilm eradication. Our findings reveal that therapy with ZIF-8@PDA NPs, when exposed to near-infrared radiation, demonstrates exceptional antibacterial efficacy and is highly effective in eradicating oral biofilms both <em>in vitro</em> and <em>ex vivo</em>. Furthermore, we used an <em>in vivo</em> rodent tooth biofilm model to demonstrate the suppression of dental caries. This work presents a promising solution for preventing and suppressing dental caries as well as other treating diseases linked to oral biofilm infections.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3730-3743"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A light-driven molecular motor-polypeptide conjugate supports controlled cell uptake†","authors":"Camilla Pegoraro, Ainoa Guinart, Esther Masiá Sanchis, Daniel Doellerer, Marc C. A. Stuart, Inmaculada Conejos-Sánchez, Ben L. Feringa and María J. Vicent","doi":"10.1039/D4TB02434F","DOIUrl":"10.1039/D4TB02434F","url":null,"abstract":"<p >While light-driven molecular motors (<strong>MMs</strong>) hold immense potential to control cell function, low biocompatibility and solubility have hampered their implementation. We developed a novel polypeptide-conjugated <strong>MM</strong> by linking a propargyl-derivatized light-driven <strong>MM</strong> to a poly-<small>L</small>-glutamic acid-based carrier (<strong>P</strong>) with inherent mitochondria tropism through click chemistry, denoted <strong>P-MM</strong>. <strong>P-MM</strong> effectively maintained the parental stability and unidirectional rotational capabilities of <strong>MM</strong> upon irradiation at 405 nm. Light-induced supramolecular conformational changes significantly increased cell uptake compared to non-irradiated controls while retaining the subcellular targeting capacity of <strong>P</strong>. <strong>P-MM</strong> exhibited minimal cytotoxicity and reactive oxygen species production, suggesting a non-disruptive interaction with cell membranes. Overall, we establish a connection between irradiation and enhanced biological responses, demonstrating the potential of integrating <strong>MMs</strong> with targeted polymeric nanocarriers for controlled, light-responsive behavior in biological systems and innovative applications in advanced therapeutic/diagnostic strategies.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 8","pages":" 2658-2665"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02434f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atomically dispersed copper(i) on tungstosilicic acid for catalytic protection against cisplatin-induced hearing loss†","authors":"Xiaochan Lu, Yin Chen, Yanmei Mo, Qingdong Zeng, Shaoqin Cen, Li Zeng, Hongyi Hu, Ao Li, Xia Gao and Bin Zhang","doi":"10.1039/D4TB02820A","DOIUrl":"10.1039/D4TB02820A","url":null,"abstract":"<p >The employment of platinum-based drugs for cancer chemotherapy, which might yield oxidative stress, is regarded as one main factor leading to hearing loss. The exact molecular mechanisms for cisplatin-induced hearing loss require further clarification, thus limiting the development of FDA-approved therapies. Herein, we mimicked the molecular structure of natural antioxidative enzymes to fabricate a four-oxygen-coordinating copper single-atom nanozyme (Cu SAN) exhibiting good superoxide dismutase and catalase activity, to alleviate the oxidative stress induced by platinum-based drugs. Notably, Cu SAN exhibited profound protective effects against cisplatin-induced hair cell damage with only 15 ng mL<small>⁻¹</small> of Cu species, successfully reversing cisplatin-induced hearing loss <em>via</em> oral administration. Due to its oxidation resistance, pretreatment with Cu SAN significantly improved cell viability and reduced ROS accumulation in cisplatin-triggered hair cell damage in HEI-OC1 cells and cochlear explants. Our results first demonstrated that cisplatin treatment induced cuproptosis in hair cells by modulating copper ion homeostasis. Further investigation revealed that Cu SAN nanozyme effectively alleviated hair cell cuproptosis by regulating FDX1 and reducing aggregated lipoacylated protein. This research underscores the promising potential of four-oxygen-coordinating Cu nanomaterials as a therapeutic approach to combat hearing loss, providing a new strategy for auditory protection.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3540-3552"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A thermoresponsive PEG-based methacrylate triblock terpolymer as a bioink for 3D bioprinting†","authors":"Kaiwen Zhang, Anna P. Constantinou, Cathal O’Connell, Theoni K. Georgiou and Amy Gelmi","doi":"10.1039/D4TB02572E","DOIUrl":"10.1039/D4TB02572E","url":null,"abstract":"<p >Thermoresponsive polymers have been extensively reported for their use in tissue engineering and drug delivery applications. They have a wide range of thermoresponsive and rheological properties controlled by their structural characteristics, such as composition and architecture. Here, the considerable potential of a PEG based, non-ionic triblock thermoresponsive copolymer, namely OEGMA300<small>₁₃</small>-<em>b</em>-BuMA<small>₂₂</small>-<em>b</em>-DEGMA<small>₁₂</small> as a bioink for 3D printing with cell encapsulation is identified. The rheological tests showed that the gel transition temperature is 8 °C with 35% w/w concentration in PBS. The printability and cytotoxicity of the thermoresponsive gel were characterised and compared with those of commercial thermoresponsive polymer Pluronic®F127 in detail. Specifically, the 35% w/w triblock copolymer presented great printability with a printing speed of 450 mm min<small>⁻¹</small> at 37 °C, and was less cytotoxic than F127 at both 20% and 30% w/w concentrations. A one-layer structure of human mesenchymal stem cell (hMSC) embedded triblock copolymer was successfully printed onto a glass slide at 37 °C. This provides an option to create a scaffold for stem cell culture and programming for further tissue engineering applications <em>via</em> direct printing of a cell-laden thermoresponsive polymer.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3593-3601"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02572e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decomposable STING nanoagonist-amplified oncolytic virotherapy through remodeling the immunosuppressive microenvironment of triple-negative breast cancer†","authors":"Min Mu, Guoqing Wang, Bo Chen, Hui Li, Chenqian Feng, Rangrang Fan, Nianyong Chen, Bo Han, Aiping Tong, Bingwen Zou and Gang Guo","doi":"10.1039/D4TB02565B","DOIUrl":"10.1039/D4TB02565B","url":null,"abstract":"<p >Oncolytic viruses (OVs) are promising for cancer treatment as they specifically replicate in tumor cells. However, the systemic delivery of OVs still faces the challenges of poor tumor targeting, short circulation periods, and limited lytic efficacy. Herein, an OV-concealed targeting nanoagonist (OV-MnO<small>₂</small>/HE) was prepared to enhance the delivery of OVs to triple-negative breast cancer (TNBC) <em>via</em> intravenous administration. Decomposable MnO<small>₂</small> biomineral shells covered the surface antigens of OVs to prevent their clearance after systemic administration. The targeting materials of HA-EGCG (HE) enhanced intratumoral accumulation <em>via</em> active targeting. After entering tumors, OV-MnO<small>₂</small>/HE readily released Mn<small>²⁺</small> and OVs, which could enhance the number of CD4<small>⁺</small>/CD8<small>⁺</small> T cells and maturation dendritic cells (DCs) due to the synergetic effect of the STING pathway and OVs, thereby activating the immune response, resulting in the significant inhibition of TNBC growth. This work highlights the potential of the STING agonist in enhancing the antitumor efficacy of OVs and provides a potent platform for TNBC therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3685-3699"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biomimetic dual-targeting nanomedicine for pancreatic cancer therapy†","authors":"Guihua Zhou, Yuan Zhang, Zhiwei Cai, Hongfei Yao, Meng Liu, Chongyi Jiang and Zhen Cheng","doi":"10.1039/D4TB02206H","DOIUrl":"10.1039/D4TB02206H","url":null,"abstract":"<p >The physiological characteristics of pancreatic cancer (PC) involve the interplay between tumor cells, cancer-associated fibroblasts (CAF) and the extracellular matrix (ECM). This intricate microenvironment contributes to the cancer's resistance to conventional chemoradiotherapy and its poor prognosis. Carbon monoxide (CO), a promising molecule in gas therapy, can effectively penetrate solid tumors and induce tumor cell apoptosis at high concentrations. However, precise dosing control remains a significant challenge in the administration of exogenous CO, and its inherent toxicity at elevated concentrations presents substantial barriers to clinical translation. In this study, we developed a novel biomimetic nanomedical drug delivery system capable of simultaneously targeting CAF and PC tumor cells, degrading the ECM, and inhibiting tumor growth. The strategy integrates iron carbonyl (FeCO), an anti-cancer agent, and losartan (Lo), a drug that degrades tumor matrix, into a biodegradable nanomaterial—mesoporous polydopamine (MPDA). The resulting nanoparticles are then coated with CAF cell membranes (CAFM) and functionalized with plectin-1 targeted peptide (PTP), a molecule that targets PC cells, to construct the (Lo + FeCO)@MPDA@CAFM-PTP nanomedicine. This system utilizes the homologous adhesion properties of CAF membranes to target CAFs, delivering Lo to degrade the ECM. Following ECM degradation, the nanomedicine penetrates further to bind to PC tumor cells <em>via</em> PTP. Then anti-cancer drug FeCO is released to react with the excessive reactive oxygen species (ROS) in PC tumor cells to produce high concentrations of CO, effectively inducing tumor cell apoptosis. The (Lo + FeCO)@MPDA@CAFM-PTP nanomedicine demonstrated significant cytotoxicity against Panc-1 cells <em>in vitro</em> and effectively inhibited PC tumor growth <em>in vivo</em>. This innovative approach holds great promise for advancing pancreatic cancer treatment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3716-3729"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a novel polyelectrolyte complex nanocomposite of modified chitosan and karaya gum for co-delivery of 5-fluorouracil and curcumin for cancer therapy","authors":"Rakshitha Anjar, Manohar Mahadev, Rompicherla Narayana Charyulu and Vishalakshi Badalamoole","doi":"10.1039/D4TB02354D","DOIUrl":"10.1039/D4TB02354D","url":null,"abstract":"<p >Combination chemotherapy is a relatively recent and preferred method for cancer treatment. Sustained delivery of dual drugs can be achieved with a suitable matrix. In the present work, a pH-responsive polyelectrolyte complex (PEC) of trimethylchitosan and carboxymethylkaraya gum containing silver nanoparticles (SNps) has been developed as a matrix material for co-delivery of the drugs, 5-fluorouracil (5-Fu) and curcumin (Cur). The experimental conditions have been optimized for high yield and high swelling of the PEC nanocomposite. <small>¹</small>H-NMR, FT-IR, FE-SEM, P-XRD, HR-TEM, EDS, TGA techniques and zeta potential measurements have been employed in the physico-chemical characterization of the nanocomposite material. The presence of SNps with an average diameter of 16.57 ± 1.25 nm influenced the surface structure and hydrophilicity of the PEC. The swelling study indicated higher swelling at pH 7.4 than at pH 1.2. The two drugs, 5-Fu and Cur, were successfully entrapped and released from the nanocomposite in a sustained manner. Cytotoxicity studies performed with the MCF-10A cell line confirmed the biocompatibility of the nanocomposite and those with the MCF-7 cell line indicated the synergistic effect of the dual drugs in controlling cancer cell growth. The overall study indicates the usefulness of the PEC nanocomposite made from modified polysaccharides, chitosan and karaya gum as a promising material for the development of a dual drug delivery system for cancer treatment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3602-3617"},"PeriodicalIF":6.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of silk fibroin-based composite films in biomedicine and biotechnology","authors":"Ke Ma, Zhi-Feng Wu, Ke-Zheng Chen and Sheng-Lin Qiao","doi":"10.1039/D4TB02616K","DOIUrl":"10.1039/D4TB02616K","url":null,"abstract":"<p >Silk fibroin has garnered significant attention as a natural biomaterial due to its exceptional biocompatibility, tunable water solubility, optical transparency and high thermal stability. In recent years, silk fibroin films have gained prominence for their ease of fabrication and unique properties. However, their intrinsic brittleness limits broader applicability in certain fields. To overcome this challenge, researchers have developed various strategies, including physical blending, chemical modification, and genetic engineering, to improve key attributes such as mechanical strength, antimicrobial activity, and electrical conductivity. These advancements have significantly broadened the utility of silk fibroin films in diverse biomedical applications. This review provides an in-depth analysis of recent progress in silk fibroin-based composite films, emphasizing their applications in bone regeneration, wound healing, and health monitoring. Modified silk fibroin composites are highlighted for their superior material properties and enhanced functional potential in these domains. Additionally, this review discusses future research directions, offering valuable insights into pathways for further innovation and practical implementation. With continued advancements, silk fibroin composite films are poised to make transformative contributions to the fields of biomedicine and biotechnology.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3494-3515"},"PeriodicalIF":6.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1,4-Bis(2-hydroxyethyl)piperazine-derived water-dispersible and antibacterial polyurethane coatings for medical catheters†","authors":"Anchal Gupta, Simran Kaur Rainu, Manleen Kaur, Mahipal Meena, Neetu Singh and Josemon Jacob","doi":"10.1039/D4TB02227K","DOIUrl":"10.1039/D4TB02227K","url":null,"abstract":"<p >To prolong usage and mitigate infections associated with bacterial colonization on medical catheters, the development of water-dispersible polyurethane (PU) coatings with bactericidal properties is desirable. With this objective, we have formulated polyurethane coatings that exhibit both antibacterial activity and water dispersibility. A piperazine-based diol, 1,4-bis(2-hydroxyethyl)piperazine (<strong>HEPZ</strong>), was synthesized and used as a chain extender in PU synthesis. The PUs were prepared using hexamethylene diisocyanate (HDI), 4,4′-methylene diphenyl diisocyanate (MDI), polyethylene glycol (PEG<small>₆₀₀</small>), and polypropylene glycol (PPG<small>₄₀₀</small>), resulting in a series of polyurethanes (<strong>PU1–PU4</strong>). MDI-containing PUs showed superior tensile strength (3.2–3.6 MPa) and elongation (67–70%) attributable to their higher aromatic content. The PEG<small>₆₀₀</small>-containing PUs (<strong>PU1</strong> and <strong>PU3</strong>) were alkylated using methyl iodide (MeI) to varying degrees whereby a significant reduction in contact angle from ∼82° to ∼62° was observed, indicating enhanced hydrophilicity. <strong>MPU3-D</strong> with 72.5% methylation demonstrated the most stable water dispersion with a particle size of ∼190.8 nm and a zeta potential of +49.0 mV. <em>In vitro</em> cytocompatibility studies further revealed that methylated <strong>PU3</strong> exhibited higher compatibility (80–90%) compared to methylated <strong>PU1</strong> (30–40%). The hemolysis test showed the non-hemolytic behavior of <strong>MPU3-D</strong> films with a % hemolysis of 0.4 ± (0.2)% making it suitable for coating on medical devices. Additionally, <strong>MPU3-D</strong> films also demonstrated antibacterial activity against Gram-negative (<em>E. coli</em>) and Gram-positive (<em>S. aureus</em>) bacteria, with zones of inhibition measuring 7 mm and 8 mm, respectively. Also, water-dispersible <strong>MPU3-D</strong>-based coatings with a hardness of ∼75 A and a thickness of ∼17 μm (as observed through FESEM) showed strong adhesion to PVC catheters, exhibiting an adhesion strength of 4B rating. Our results suggest that water-dispersible polyurethane coatings with antibacterial properties are promising materials to reduce catheter-associated infections and enhance patient care.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 10","pages":" 3350-3364"},"PeriodicalIF":6.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Room temperature operated flexible MWCNTs/Nb2O5 hybrid breath sensor for the non-invasive detection of an exhaled diabetes biomarker†","authors":"Gulshan Verma, Sonu Sarraf, Aviru K. Basu, Pranay Ranjan and Ankur Gupta","doi":"10.1039/D4TB02644F","DOIUrl":"10.1039/D4TB02644F","url":null,"abstract":"<p >Advancements in diabetes management increasingly rely on non-invasive monitoring of biomarkers present in exhaled breath. This study introduces a novel room temperature operated flexible acetone sensing platform, leveraging a hybrid material composed of multi-walled carbon nanotubes (MWCNTs) and niobium oxide (Nb<small>₂</small>O<small>₅</small>). The platform demonstrates sensitivity and selectivity towards acetone, a prominent biomarker of diabetes, offering promise for real-time health monitoring applications. The sensor exhibited a characteristic feature of fast response (25 s) and recovery times (46 s) at 50 ppm, good selectivity, and stability with a detection limit of 330 ppb. Additionally, the sensor's characteristic features were collected, and four different machine learning (ML) algorithms were applied to visualize and classify the gases with good quantification. Out of all algorithms, the random forest (RF) algorithm demonstrates the best performance. Furthermore, regression modelling was also used to quantitatively predict the gas concentration. In addition, the sensor was shown to distinguish between signals from simulated diabetic and healthy breath samples. These sensing performances indicate that the breath sensor has practical applications that could potentially provide a non-invasive monitoring method for diabetic patients.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 10","pages":" 3460-3470"},"PeriodicalIF":6.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}