Journal of Materials Chemistry B最新文献

{"title":"Quantitatively analyzing the dissociation and release of disulfide-containing organic nanoparticles†","authors":"Wenhai Lin, Lei Yin, Xin Wang, Chaonan Li, Wei Zhang, Qing Pei, Huixuan Qi, Tingting Sun, Zhigang Xie and Jingkai Gu","doi":"10.1039/D4TB00804A","DOIUrl":"10.1039/D4TB00804A","url":null,"abstract":"<p >The disintegration of nanoparticles and drug release are important and imperative for nanoparticle formulations of therapeutic agents. However, quantitatively monitoring the drug release of nanomedicines is a major challenge. In this work, boron-dipyrromethene (BDP) was applied as a model drug to study the disassembly of nanoparticles and drug release. BDP dimers with disulfide and ester bonds were synthesized, and their nanoparticles were made. The accurate analysis of bond breaking in BDP nanoparticles could not be realized by using confocal laser scanning microscopy. Hence, the possible products after bond cleavage were quantified by using liquid chromatography tandem mass spectrometry (LC-MS/MS). BDP nanoparticles could be endocytosed into cancer cells, and the disulfide bonds and ester bonds were broken to promote the disassociation of nanoparticles and BDP release. Then, near-infrared BDP nanoparticles were investigated in live mice by near-infrared fluorescence imaging and LC-MS/MS. The release of BDP was low (&lt;10%) and BDP maintained the original dimer structure <em>in vivo</em>, which showed that the bond breaking for BDP nanoparticles was difficult <em>in vivo</em>. These results could help us understand the breaking law of disulfide bonds and ester bonds in nanoparticles and are beneficial for developing practical new drug formulations.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of metal–organic framework materials in regenerative medicine","authors":"Siwei Li, Yunhe Lin, Chuzi Mo, Jiaming Bi, Chengxia Liu, Yu Lu, Bo Jia, Shuaimei Xu and Zhongjun Liu","doi":"10.1039/D4TB00226A","DOIUrl":"10.1039/D4TB00226A","url":null,"abstract":"<p >In the past few decades, scaffolds manufactured from composite or hybrid biomaterials of natural or synthetic origin have made great strides in enhancing wound healing and repairing fractures and pathological bone loss. However, the prevailing use of such scaffolds in tissue engineering is accompanied by numerous constraints, including low mechanical stability, poor biological activity, and impaired cell proliferation and differentiation. The performance of scaffolds in wound and bone tissue engineering may be enhanced by some modifications in the synthesis of nanoscale metal–organic framework (nano-MOF) scaffolds. Nano-MOFs have attracted researchers’ attention in recent years due to their distinctive features, which include tenability, biocompatibility, good mechanical stability, and ultrahigh surface area. The biological properties of scaffolds are enhanced and tissue regeneration is facilitated by the introduction of nano-MOFs. Moreover, the physicochemical characteristics, drug loading, and ion release capacities of the scaffolds are improved by the nanoscale structure and topological features of nano-MOFs, which also control stem cell differentiation, proliferation, and attachment. This review provides further comprehensive detail about the most recent uses of nano-MOFs in tissue engineering. The distinct characteristics of nano-MOFs are explored in enhancing tissue repair, wound healing, osteoinduction, and bone conductivity. Significant attributes include high antibacterial activity, substantial drug-loading capacity, and the ability to regulate drug release. Finally, this discussion addresses the obstacles, clinical impediments, and considerations encountered in the application of these nanomaterials to diverse scaffolds, tissue-mimicking structures, dressings, fillers, and implants for bone tissue repair and wound healing.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles constructed from natural polyphenols are used in acute kidney injury","authors":"Xiaohua Liu, Yike Guo, Jiangpeng Pan, Tingting Wu, Bing Zhao, Shuyi Wei, Wei Jiang and Ying Liu","doi":"10.1039/D4TB00837E","DOIUrl":"10.1039/D4TB00837E","url":null,"abstract":"<p >Acute kidney injury (AKI) is a severe clinical syndrome characterized by rapid deterioration of renal function caused by a variety of pathogeneses. Natural polyphenols have been considered to have potential in the treatment of AKI due to their powerful antioxidant and anti-inflammatory activities, but their low bioavailability <em>in vivo</em> limits their efficacy. Polyphenol nanoparticles based on a nano-delivery system show good effects in reducing kidney injury, improving renal function and promoting renal tissue repair, and brings new hope and possibility for the treatment of AKI. This review provides an overview of the common characteristics, treatments, and associated adverse effects of AKI. The classification and bioavailability of polyphenols as well as their therapeutic role in AKI and potential possible effects are outlined. The potential therapeutic effects of polyphenol-based nanoparticles on AKI and the underlying mechanisms are discussed.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of toxic cypermethrin pesticides in drinking water by simple graphitic electrode modified with Kraft lignin@Ni@g-C3N4 nano-composite†","authors":"Shumaila Razzaque, Muhammad Abubakar, Muhammad Asim Farid, Rehana Zia, Shahid Nazir, Humaira Razzaque, Abid Ali, Zulfiqar Ali, Asif Mahmood, Waheed Al-Masry, Toheed Akhter and Sadaf Ul Hassan","doi":"10.1039/D4TB00951G","DOIUrl":"10.1039/D4TB00951G","url":null,"abstract":"<p >The detrimental effects of widespread pesticide application on the health of living organisms highlight the urgent need for technological advancements in monitoring pesticide residues at trace levels. This study involves the synthesis of a distinctive sensing material, KL@Ni@g-C<small>₃</small>N<small>₄</small>, which comprises nanocomposites of graphitic carbon nitride with Kraft lignin and nickel. The prepared samples were characterized using FT-IR, PXRD, TEM, SEM, and EDX techniques. The KL@Ni@g-C<small>₃</small>N<small>₄</small> nanocomposite was drop-cast on a graphite electrode. Subsequently, this fabricated electrode was used to detect cypermethrin (CYP) residues in drinking water. The redox properties of the fabricated sensors were evaluated using electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The limit of detection (LOD) of the fabricated sensor was determined to be 0.026 μg mL<small>⁻¹</small>, which is below the maximum residual limits of CYP in the environment (0.5 μg mL<small>⁻¹</small>) and within the acceptable range for food products (∼0.05 to 0.2 μg mL<small>⁻¹</small>). Therefore, this study proposes a promising alternative to conventional methods for detecting pesticides in drinking water.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-infrared passive spectroscopic imaging for visualizing tooth quality","authors":"So Yamashita, Masahiro Okada, Takuya Matsumoto and Ichiro Ishimaru","doi":"10.1039/D4TB00280F","DOIUrl":"10.1039/D4TB00280F","url":null,"abstract":"<p >Although the measurement of tooth quality is necessary for precise prediction of caries formation, typical measurement methods include tooth-hardness measurements and absorption spectroscopy, which generally use infrared light irradiation. These methods are destructive or invasive, and obtaining two-dimensional information in the oral cavity is difficult. Mid-infrared emissions from the surface of an object reflect intrinsic vibrations of molecules in the object. In this study, a mid-infrared passive spectroscopic imaging system was developed using an inexpensive uncooled microbolometer array sensor with an optimized multi-slit, which eliminated the cancellation of interference intensities between two adjacent emission points, to obtain two-dimensional information from an object without external infrared light irradiation. First, the feasibility of obtaining two-dimensional information on tooth quality using the proposed system was examined, and emission spectra attributed to phosphate ions in hydroxyapatite (HAp), the main component of enamel, were successfully obtained from bovine teeth. Further, the hardness of bovine teeth was measured, and a correlation (<em>R</em><small>²</small> = 0.8067) between the Vickers hardness and peak area ratio of phosphate ions assigned to the crystalline and amorphous phases of a tooth was established. Additionally, tooth-hardness visualization in a non-contact manner was demonstrated as two-dimensional information using the obtained regression equation.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb00280f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unleashing the antibacterial and antibiofilm potential of silica-based nanomaterials functionalized with an organotin(iv) compound†","authors":"Victoria García-Almodóvar, Perla del Rosario Ardiles, Sanjiv Prashar, Paulina Laura Páez and Santiago Gómez-Ruiz","doi":"10.1039/D4TB01106F","DOIUrl":"10.1039/D4TB01106F","url":null,"abstract":"<p >Bacterial diseases caused by superbugs are expected to be the main cause of death worldwide within a decade as a consequence of the resistance they are acquiring to the antibiotics currently in use, therefore, the field of new antibacterial treatments is currently being thoroughly studied. The present work focuses on the synthesis, functionalization, characterization and antibacterial behaviour of different systems based on three different silica-based nanostructured materials (MSN, mesoporous silica nanoparticles, SBA-15 Santa Barbara amorphous-15 and FSP fibrous slica nanoparticles) which serve as scaffolds for the support of different platforms to target and treat bacterial diseases and biofilm formation. Thus, (3-carboxypropyl)triphenylphosphonium bromide (PPh<small>₃</small><small>⁺</small>) and a cytotoxic organotin(<small>IV</small>) fragment (Sn) have been incorporated in the silica-based materials to study their potential activity in different antibacterial applications. After a complete characterization of the synthesized systems, which confirmed the incorporation of both the targeting and the therapeutic fragments within the nanostructured materials, the antibacterial study of the materials demonstrated bactericidal capacity against <em>Escherichia coli</em> and perturbation of the bacteria metabolism <em>via</em> oxidative stress through an enhanced ROS (reactive oxygen species) production. In addition, biofilm inhibition and eradication tests of bacterial strains were carried out, showing that the activity of the materials in both biofilm inhibition and eradication is dependent on the concentration of the material. Furthemore, the material MSN-AP(1:1)-PPh<small>₃</small><small>⁺</small>-Sn containing the targeting triphenylphosphonium and a “SnPh<small>₃</small>” fragment is capable of inhibiting and eradicating up to 50% of the formation of biofilms, which is outstanding for metallodrug-functionalized silica-based systems compared with other materials based on metal nanoparticles supported on silica. Finally, a hemolysis study was carried out with the nanostructured systems proving to be non-toxic, making them adequate for their subsequent use in preclinical trials through <em>in vivo</em> models.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb01106f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing antibacterial materials through simulation and theory","authors":"Jiaqi Li, Xueqing Jin, Zheng Jiao, Lijuan Gao, Xiaobin Dai, Linghe Cheng, Yuming Wang and Li-Tang Yan","doi":"10.1039/D4TB01277A","DOIUrl":"10.1039/D4TB01277A","url":null,"abstract":"<p >Antibacterial materials have a wide range of potential applications in bio-antimicrobial, environmental antimicrobial, and food antimicrobial fields due to their intrinsic antimicrobial properties, which can circumvent the development of drug resistance in bacteria. Understanding the intricate mechanisms and intrinsic nature of diverse antibacterial materials is significant for the formulation of guidelines for the design of materials with rapid and efficacious antimicrobial action and a high degree of biomedical material safety. Herein, this review highlights the recent advances in investigating antimicrobial mechanisms of different antibacterial materials with a particular focus on tailored computer simulations and theoretical analysis. From the view of structure and function, we summarize the characteristics and mechanisms of different antibacterial materials, introduce the latest advances of new antibacterial materials, and discuss the design concept and development direction of new materials. In addition, we underscore the significance of employing simulation and theoretical methodologies to elucidate the intrinsic antimicrobial mechanisms, which is crucial for a comprehensive comprehension of the control strategies, safer biomedical applications, and the management of health and environmental concerns associated with antibacterial materials. This review could potentially stimulate further endeavors in fundamental research and facilitate the extensive utilization of computational and theoretical approaches in the design of novel functional nanomaterials.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing thermoreversible gels for extended release of mosquito repellent†","authors":"Javier Jimenez, James E. Cilek, Sierra M. Schluep and Jeffrey G. Lundin","doi":"10.1039/D4TB01384K","DOIUrl":"10.1039/D4TB01384K","url":null,"abstract":"<p >Mosquito-borne diseases are responsible for 700 000 deaths annually. Current outdoor protective strategies primarily focus on direct skin application of commercial repellents (<em>i.e.</em>, aerosol sprays or topical lotions) which are typically limited to efficacy times of ≤10 hours due to rapid evaporation and dermal absorption. Consequently, frequent reapplication for continuous protection can increase associated health hazards and cause noncompliance. This study utilizes Hansen solubility parameter modeling to design physical gels composed of insect-repelling <em>N</em>,<em>N</em>-diethyl-<em>meta</em>-toluamide (DEET) and modacrylic copolymer poly(acrylonitrile-<em>co</em>-vinyl chloride) (P(AN–VC)). The P(AN–VC)/DEET composites exhibit tunable and reversible sol–gel transition temperatures that can meet the thermomechanical stability demands of the intended application and permit facile transition to commercial melt processing techniques such as injection molding, filament spinning, or film casting. P(AN–VC)/DEET gel films demonstrate mosquito repellency for more than half a year—performing longer than any other known material to date—due to the high reservoir of repellent and its desorption hindrance from the polymer matrix. Therefore, P(AN–VC)/DEET gels hold significant potential for extended protection against mosquitos and other biting arthropods.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron oxide nanoparticle-stabilized Pickering emulsion-templated porous scaffolds loaded with polyunsaturated fatty acids (PUFAs) for bone tissue engineering†","authors":"W. Aadinath, Teja K. S. P. S., Iniyan Saravanakumar and Vignesh Muthuvijayan","doi":"10.1039/D4TB00286E","DOIUrl":"10.1039/D4TB00286E","url":null,"abstract":"<p >Dietary intake of ω-3-polyunsaturated fatty acids (PUFAs) can significantly improve the expression levels of alkaline phosphatase (ALP) and osteocalcin. However, PUFAs are hydrophobic and highly sensitive to temperature, oxygen concentration, pH, and ionic strength. Hence, it is challenging to use PUFAs as bioactive compounds for bone tissue engineering. Here, we encapsulated PUFAs in liposomes to improve their stability. The hydrodynamic size of the PUFA-loaded liposomes was found to be 121.3 ± 35 nm. GC-MS analysis showed that the encapsulation efficiency of the PUFAs was 19.9 ± 3.4%. These PUFA-loaded liposomes were loaded into porous scaffolds that were prepared by polymerizing glycidyl methacrylate and trimethylolpropane triacrylate monomers using the Pickering emulsion polymerization technique. Oleic acid-coated iron oxide nanoparticles were used as the stabilizing agent to prepare these acrylate-based scaffolds containing PUFA-loaded liposomes (P-Lipo-IO(GMA-TMPTA)). SEM micrographs confirmed the porous nature of the scaffolds and the presence of well-adhered liposomes. An <em>in vitro</em> cytotoxicity study conducted using MG63 cells confirmed that these scaffolds showed desirable cytocompatibility. Cell adhesion study showed a well-spread morphology, indicating firm adhesion of the cells. The alizarin red staining of P-Lipo-IO(GMA-TMPTA) scaffolds showed 3- and 2-fold higher calcium deposition compared to the control on days 7 and 14, respectively. ALP activity was also 2-fold higher than that of the control on day 14. RT-PCR analysis of cells exposed to P-Lipo-IO(GMA-TMPTA) scaffolds showed significantly higher expression of osteogenic markers compared to the control. An antibacterial study conducted on <em>Staphylococcus aureus</em> showed a higher percentage inhibition and reactive oxygen species generation in samples treated with P-Lipo-IO(GMA-TMPTA) scaffolds. These desirable biological properties indicate that the developed scaffolds are suitable for bone tissue engineering.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coaxial bioprinting of a stentable and endothelialized human coronary artery-sized in vitro model†","authors":"Ashfaq Ahmad, Seon-Jin Kim, Yun-Jin Jeong, Muhammad Soban Khan, Jinsoo Park, Dong-Weon Lee, Changho Lee, Yeong-Jin Choi and Hee-Gyeong Yi","doi":"10.1039/D4TB00601A","DOIUrl":"10.1039/D4TB00601A","url":null,"abstract":"<p >Atherosclerosis accounts for two-thirds of deaths attributed to cardiovascular diseases, which continue to be the leading cause of mortality. Current clinical management strategies for atherosclerosis, such as angioplasty with stenting, face numerous challenges, including restenosis and late thrombosis. Smart stents, integrated with sensors that can monitor cardiovascular health in real-time, are being developed to overcome these limitations. This development necessitates rigorous preclinical trials on either animal models or <em>in vitro</em> models. Despite efforts being made, a suitable human-scale <em>in vitro</em> model compatible with a cardiovascular stent has remained elusive. To address this need, this study utilizes an in-bath bioprinting method to create a human-scale, freestanding <em>in vitro</em> model compatible with cardiovascular stents. Using a coaxial nozzle, a tubular structure of human coronary artery (HCA) size is bioprinted with a collagen-based bioink, ensuring good biocompatibility and suitable rheological properties for printing. We precisely replicated the dimensions of the HCA, including its internal diameter and wall thickness, and simulated the vascular barrier functionality. To simplify post-processing, a pumpless perfusion bioreactor is fabricated to culture a HCA-sized model, eliminating the need for a peristaltic pump and enabling scalability for high-throughput production. This model is expected to accelerate stent development in the future.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/tb/d4tb00601a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}