Journal of Materials Chemistry B最新文献

{"title":"Improved biostability of gold nanostars for enhanced intercellular interactions","authors":"Anastasiia Tukova, Su Su Thae Hnit, Dan Wang, Megan Lord, Alison Rodger and Yuling Wang","doi":"10.1039/D5TB00523J","DOIUrl":"10.1039/D5TB00523J","url":null,"abstract":"<p >Gold nanostars (AuNS) have emerged as promising platforms for biosensing, bioimaging, and therapeutic applications due to their strong plasmonic enhancement and tunable optical properties. However, their applications are hindered by stability issues in complex biological environments, affecting their interactions with biomolecules and cells. To address this challenge, we employ advanced characterization techniques, including surface-enhanced Raman spectroscopy (SERS) to track the stability and intracellular fate of AuNS. We found that AuNS functionalized with 4-mercaptobenzoic acid, acting as SERS nanotags, exhibit exceptional biostability in cell culture media, both uncoated and precoated with bovine serum albumin (BSA). High-resolution 2D and 3D SERS imaging revealed cell-type-dependent uptake, with immune cells displaying greater internalization than cancer cells, while protein precoating had minimal influence. Cytocompatibility assays confirmed low toxicity and suitability of AuNS for biological applications. Our findings highlight the potential of improved biostability of AuNS for precise intracellular probing, paving the way for advanced nanoparticle-based applications that would enable spatially resolved biomolecular analysis in live cells.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 10973-10981"},"PeriodicalIF":6.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A photoactivatable nano-liposome containing tripartite therapeutics for photothermal-triggered chemotherapy","authors":"Yana Li, Yiduo Zhan, Yifang Liu, Jingyang Su, Jingchao Li, Yongzhi Men and Na Zhu","doi":"10.1039/D5TB01368B","DOIUrl":"10.1039/D5TB01368B","url":null,"abstract":"<p >Chemotherapy represents a conventional method for cancer treatment, but it inevitably has the issues of low clinical efficacy, therapy resistance and severe side effects. In view of the unique characteristics of nanosystems that can deliver drugs in an effective and safe manner, we report photoactivatable nano-liposomes containing a hypoxia-responsive prodrug tirapazamine (TPZ), glucose oxidase (GOx) and indocyanine green (ICG) for photothermal-triggered chemotherapy of subcutaneous metastatic breast cancer. The nano-liposomes (termed IGT@NPs) are fabricated using a thermo-responsive liposome component to enable photoactivatable drug delivery <em>via</em> the photothermal effect. IGT@NPs mediate the local temperature increase under near-infrared (NIR) laser irradiation, not only allowing for photothermal therapy (PTT), but also achieving on-demand TPZ and GOx release. In the tumor microenvironment, GOx catalyzes the consumption of glucose and oxygen, resulting in aggravated hypoxia levels. As a consequence, TPZ is activated through the aggravated hypoxic microenvironment to trigger the chemotherapeutic action. Therefore, photothermal-triggered chemotherapy is achieved by IGT@NPs, which leads to the effective inhibition of primary tumor growth and metastatic tumor occurrence in subcutaneous 4T1 tumors. This current study thus provides a photoactivatable nanosystem containing tripartite therapeutics for cancer treatment with controllable and combined functions.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11835-11845"},"PeriodicalIF":6.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysiloxane-based polyurethane/quaternary ammonium-zwitterionic pressure-sensitive adhesive composite double dressing with antimicrobial and antifouling properties","authors":"Yichao Hu, Weiguang Jia, Xionghui Wu, Yaling Lin and Anqiang Zhang","doi":"10.1039/D5TB01431J","DOIUrl":"10.1039/D5TB01431J","url":null,"abstract":"<p >The development of wound dressings that combine mechanical strength, flexibility, biocompatibility, and multifunctionality continues to pose significant challenges in biomedical engineering. This study introduces an innovative bilayer polyurethane composite dressing featuring distinct functional layers. The polyurethane protective layer (PUPL), fabricated from polydimethylsiloxane-based polyurethane, functions as a hydrophobic, mechanically robust barrier that simultaneously provides structural integrity, flexibility, and effective protection against fluid penetration and environmental contaminants, thereby minimizing external interference with the wound healing process. The polyurethane functional layer (PUFL) comprises cationically and zwitterionically modified polyurethane pressure-sensitive adhesives, engineered to exhibit optimal differential adhesion properties in both wet and dry conditions along with multifunctional characteristics. This modification strategy harnesses the antimicrobial efficacy of cationic polymers while mitigating potential wound inflammation through zwitterionic ions that reduce cation-induced protein adsorption. Furthermore, incorporating polyethylene glycol into the polyurethane pressure-sensitive adhesive's soft segment enhances the material's hydrophilicity and moisture retention capacity, promoting an optimal moist wound healing environment. The resulting bilayer dressing demonstrates superior mechanical properties, excellent flexibility, and appropriate water vapor transmission rates, enabling secure wound adhesion. Moreover, it exhibits remarkable biocompatibility along with pronounced antimicrobial and antifouling capabilities. The synergistic interaction between the hydrophobic protective layer and the functional adhesive layer offers a promising platform for advancing next-generation wound healing materials.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11392-11406"},"PeriodicalIF":6.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering therapeutic scaffolds: integrating drug delivery with tissue regeneration","authors":"Melika Mansouri Moghaddam, Mohamad Sadegh Aghajanzadeh and Rana Imani","doi":"10.1039/D5TB01338K","DOIUrl":"10.1039/D5TB01338K","url":null,"abstract":"<p >Tissue engineering (TE) has revolutionized regenerative medicine by integrating scaffolds, cells, and bioactive molecules to repair or replace damaged tissues; the core triad of TE are scaffolds, cells, and biochemical signals. Although advances in biomaterials development and scaffold fabrication techniques have led to significant progress in TE, the effective delivery of bioactive agents, such as growth factors (GFs), antibiotics, anti-inflammatories, and small molecules, remains a challenge due to their short half-lives and uncontrolled release kinetics. This study explores the synergistic potential of drug delivery systems (DDS) embedded within tissue-engineered scaffolds, emphasizing their role in enhancing regenerative outcomes through controlled spatiotemporal release of therapeutic agents. This review highlights drug-activated scaffolds as a transformative solution, combining structural support with localized, sustained drug release to modulate cellular behaviours (proliferation, differentiation, ECM production) and mitigate systemic side effects. We classify bioactive agents by function and analyse their incorporation methods, pre-, during-, or post-scaffold fabrication, to achieve precise release profiles tailored to specific tissues. Key mechanisms of drug loading and release are critically evaluated. Despite progress, challenges persist in scalability, regulatory approval, and mimicking natural healing cues. We discuss emerging trends, including innovative scaffolds with on-demand drug release and combinatorial approaches leveraging biomaterials and stem cells. By bridging gaps between DDS and TE, this paradigm promises to overcome limitations of conventional transplants and synthetic implants. Future directions include optimizing bioink formulations for 3D bioprinting, improving bioactive agent stability, and addressing translational barriers for clinical adoption. This comprehensive review underscores the potential of bioactivated scaffolds to redefine regenerative strategies, offering insights into design principles, therapeutic applications, and hurdles for next-generation TE solutions.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 10780-10835"},"PeriodicalIF":6.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell membrane biomimetic nanomaterials: a novel strategy for tumor immunotherapy","authors":"Ziyuan Jing, Wenyu Zhao, Xuezhu Wang, Guifang Chen and Bo Tian","doi":"10.1039/D5TB01537E","DOIUrl":"10.1039/D5TB01537E","url":null,"abstract":"<p >Cell membrane biomimetic nanoparticles (CMBNs) represent a promising avenue in tumor treatment due to their unique characteristics, including immune evasion, prolonged circulation time, and tumor-specific targeting capabilities. These properties enable precise drug delivery to tumor sites, thereby improving therapeutic efficacy. Mixed membrane biomimetic nanoparticles are also reviewed for their ability to integrate multiple therapeutic functions, enhancing outcomes in combination therapies such as photothermal, photodynamic, and sonodynamic therapies. The application of CMBNs in tumor treatment as a combination therapy has not yet been comprehensively summarized and evaluated. This indicates that there is a lack of detailed research on the effectiveness, safety, and how this technology can be combined with other treatment methods in clinical practice. This review concludes that tailoring membrane materials to specific therapeutic needs is key to optimizing treatment strategies and advancing clinical applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 11909-11927"},"PeriodicalIF":6.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An artificial intelligence-enhanced early ovarian cancer diagnosis biosensor","authors":"Tao Hu, Haoyu Xiao, Shanling Ji, Zhihao Wu, Yunlin Quan, Wang Zhen, Xiao Li, Jianxiong Zhu and Zhonghua Ni","doi":"10.1039/D5TB00993F","DOIUrl":"10.1039/D5TB00993F","url":null,"abstract":"<p >In early cancer diagnosis, extracellular vesicles (EVs) are more advantageous than circulating tumor cells due to their smaller size, greater stability, and enhanced tissue penetration. These qualities lead to higher EV concentrations in body fluids, facilitating early detection. This study leverages surface-enhanced Raman scattering (SERS) for EV detection, employing a novel biosensor made with a molybdenum disulfide (MoS<small>₂</small>) composite film on silicon and demonstrating a lower limit of detection (LOD) and multi-marker synchronous quantitative testing performance compared to existing methodologies. This biosensor efficiently measures EV concentrations and precisely detects three specific proteins on ovarian cancer EVs simultaneously (CD63, CD24, and CA125). Using the ovarian cancer cell line HO8910, the sensor demonstrated a detection limit of 1.4 × 10<small>⁴</small> particles per mL and a wide linear range of 3.4 × 10<small>⁴</small> particles per mL to 3.4 × 10<small>⁸</small> particles per mL. It also effectively discriminated between serum samples from healthy individuals and ovarian cancer patients at different stages. Additionally, machine learning was applied to analyze detection data, resulting in a diagnostic model with a 97.78% prediction accuracy. This highlights the sensor's potential in revolutionizing early cancer detection and establishing new diagnostic models.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11696-11707"},"PeriodicalIF":6.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic lymph node-like scaffolds for optimized CAR-T cell expansion and potentiated antitumor efficacy","authors":"Huajin Zhang, Fujun Liu, Junyilang Zhao, Yong Wang, Yuge Shen, Qiqi Li, Hui Luo, Yu Chen, Rong Li, Fan Zhu, Shuo Xie, Yinhao Wei, Xupeng Gou, Danling Hu, Zhengji Li and Hanshuo Yang","doi":"10.1039/D5TB01594D","DOIUrl":"10.1039/D5TB01594D","url":null,"abstract":"<p >Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable promise in treating hematological malignancies. However, the <em>ex vivo</em> expansion of CAR-T cells is time-consuming, potentially impairing CAR-T cell function. Physiologically, T cell activation and proliferation occur within the lymph node (LN) paracortex, a dynamic environment structured by a three-dimensional (3D) reticular network (RN) that promotes cell migration and mediator delivery. Mimicking this physiological niche offers a compelling strategy to improve CAR-T cell expansion. Inspired by the structure of the RN, we developed a biomimetic RN-like poriferous microsphere (PM) to establish a 3D culture platform optimized for both T cell and CAR-T cell proliferation. This engineered system not only significantly enhanced the proliferation rates of human T cells and CAR-T cells compared to conventional methods, but also preserved a higher proportion of central memory T cells (T<small>_CM</small>) and reduced the expression of exhaustion markers (PD-1, TIM-3, and LAG-3). Moreover, CAR-T cells expanded in PMs exhibited superior anti-tumor efficacy in both <em>ex vivo</em> and <em>in vivo</em> models, which correlated with the enrichment of pathways associated with robust T cell function at the RNA level. Overall, this biomimetic platform addresses critical limitations in human T/CAR-T cell expansion, preserving cell function and improving therapeutic outcomes.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11708-11721"},"PeriodicalIF":6.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy","authors":"Hongli Yu, Jianqin Yan, Zhipeng Li, Tingting Song, Fang Ning, Jinshan Tan and Yong Sun","doi":"10.1039/D5TB90131F","DOIUrl":"10.1039/D5TB90131F","url":null,"abstract":"<p >Correction for ‘Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy’ by Hongli Yu <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2023, <strong>11</strong>, 415–429, https://doi.org/10.1039/D2TB02329F.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 34","pages":" 10684-10685"},"PeriodicalIF":6.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90131f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel near-infrared solid-state probe for monitoring carbon monoxide in cholestatic liver injury and toxic hepatitis","authors":"Qian Song, Gui-Qin Fu, Xiao-Fan Xu, Jing-Jing Chao, Jiang-Hong Liu, Guo-Jiang Mao, Yongfei Li, Juan Ouyang, Liufang Hu and Chun-Yan Li","doi":"10.1039/D5TB01448D","DOIUrl":"10.1039/D5TB01448D","url":null,"abstract":"<p >Carbon monoxide (CO) is an important gas transporter and is closely related to a variety of physiological and pathological processes. Many fluorescent probes have been prepared for detecting CO, but most of them suffer from water-soluble fluorophores, which diffuse easily and are limited for application <em>in vivo</em>. Herein, a new solid-state fluorophore (<strong>HPQ-IM-OH</strong>) is prepared by introducing isophorone to HPQ, which has a long emission wavelength (680 nm) and good diffusion-resistance ability. The solid-state fluorescent probe (<strong>HPQ-IM-CO</strong>) is constructed using the allyl formate group as a recognition group for CO. The probe itself does not exhibit fluorescence. When CO and Pd<small>²⁺</small> are added, <strong>HPQ-IM-OH</strong> is released. The photoinduced electron transfer (PET) process is turned off, and the excited-state intramolecular proton transfer (ESIPT) process is turned on, emitting a strong solid-state fluorescence signal. Due to low cytotoxicity, <strong>HPQ-IM-CO</strong> can be used to detect exogenous and endogenous CO in cells and is capable of imaging over long periods. In particular, the probe can be used for long-term imaging of CO up-regulation in cholestatic liver injury, and it can also be used for long-term imaging of CO up-regulation in toxic hepatitis, and the therapeutic effects of three hepatoprotective drugs (NAC, DDB and GSH) can be assessed.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 10893-10902"},"PeriodicalIF":6.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards scalable broad-spectrum photodynamic antimicrobial textiles: synergistic effect of Rose Bengal and commercial cationic fixative on polyamide fabrics","authors":"Inés Martínez-González, Pilar Moya, Inmaculada Andreu, Pablo Díaz García, Alberto Blazquez-Moraleja, Sonia G. Delgado, Ildefonso Ayala, Alejandro Mateos-Pujante, Marilés Bonet-Aracil, M. Luisa Marin and Francisco Bosca","doi":"10.1039/D5TB01089F","DOIUrl":"10.1039/D5TB01089F","url":null,"abstract":"<p >The use of photoactive textiles to reduce infection transmission in healthcare facilities and hospitals is not on the market due to the lack of scalable and cost-effective processes to prepare these materials. To address this issue, a new photodynamic antimicrobial fabric of polyamide with Rose Bengal (RB) and a commercial cationic fixative (CF) was prepared with a simple and scalable procedure using a conventional and industrialized process for incorporating dyes into textiles. Both fabrics (with and without CF) produced more than 99% inactivation of Gram-positive and Gram-negative bacteria (<em>Enterococcus faecalis</em> and <em>Escherichia coli</em>, respectively), as well as viruses such as adenovirus rAd5. Nevertheless, it is worth highlighting that the RB fabric with CF achieved 99.9999% inactivation of <em>E. coli</em> and 99.9% inactivation of fungi such as <em>Candida albicans</em>. The study was performed upon typical indoor illumination with visible light (400–700 nm, 11.3 ± 0.2 mW cm<small>⁻²</small>) during periods covering between 30 and 120 min, according to the tested microorganism. Tests performed with textiles to evaluate the persistence of the RB color in them and their capability to photosensitize the inactivation of microorganisms revealed that the CF improves the robustness of the fabric. Furthermore, the photophysical and photodynamic properties of the fabrics were evaluated by direct and indirect methods. In this context, the formation of photoactivable complexes was observed through the association of RB with CF. Moreover, it was established that the remarkable photodynamic efficiency using the fabric with CF is produced through an electron transfer from microorganisms to an excited RB–CF complex (Type I) and singlet oxygen generated from the triplet excited state of free RB (Type II).</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 34","pages":" 10662-10674"},"PeriodicalIF":6.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01089f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}