Journal of Materials Chemistry B最新文献_第6页

Oxygen vacancy-containing hafnium-dioxide/polyetheretherketone composite with good photothermal performance and bioactivity for treatment of tumors and infection as well as the promotion of pro-osteogenesis† 含氧真空的二氧化铪/聚醚醚酮复合材料具有良好的光热性能和生物活性，用于治疗肿瘤和感染以及促进促骨生成†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-11 DOI: 10.1039/D4TB02869D

Yong Dai, Zhe Li, Xiaofeng Ji, Peng Cheng, Xingshi Yuan, Kerong Wu, Deqiang Wang, Jie Wei and Xifu Shang

{"title":"Oxygen vacancy-containing hafnium-dioxide/polyetheretherketone composite with good photothermal performance and bioactivity for treatment of tumors and infection as well as the promotion of pro-osteogenesis†","authors":"Yong Dai, Zhe Li, Xiaofeng Ji, Peng Cheng, Xingshi Yuan, Kerong Wu, Deqiang Wang, Jie Wei and Xifu Shang","doi":"10.1039/D4TB02869D","DOIUrl":"https://doi.org/10.1039/D4TB02869D","url":null,"abstract":"The surgical treatment of bone tumors generally causes bone defects, whilst postoperative infection and tumor recurrence may also occur. Currently, it is still a huge challenge to design multi-functional biomaterials that both eradicate residual tumor cells and bacteria whilst also promoting osteogenesis. Herein, hafnium oxide with an oxygen vacancy (HfO2−x) was synthesized via a deoxidation reaction and was shown to exhibit excellent photothermal performance. Moreover, a composite based on polyetheretherketone (PEEK) containing HfO2−x (PBHC) was fabricated and displayed good photothermal performance that effectively ablated the tumor cells and eradicated bacteria in vitro under 808 nm NIR laser irradiation. Moreover, the PBHC with good photothermal performance exhibited excellent ability for the treatment of tumors and infection in vivo. Further, PBHC significantly boosted the osteoblastic differentiation of bone mesenchymal stem cells in vitro and promoted bone regeneration in vivo due to the osteogenic activity of HfO2−x. PBHC is a multi-functional biomaterial with good biocompatibility, photothermal performance and pro-osteogenic properties that can overcome the triple challenges of tumor recurrence, bacterial infection and bone defects. In summary, PBHC with tumor/bacteria-eradicating and pro-osteogenesis effects could be applicable for the simultaneous treatment of tumors and infection as well as the repair of bone defects.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5670-5685"},"PeriodicalIF":6.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Designing a multifaceted bio-interface nanofiber tissue-engineered tubular scaffold graft to promote neo-vascularization for urethral regeneration 修正：设计一种多面生物界面纳米纤维组织工程管状支架，促进尿道再生的新血管形成

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-10 DOI: 10.1039/D5TB90064F

Yuqing Niu, Guochang Liu, Ming Fu, Chuangbi Chen, Wen Fu, Zhao Zhang, Huimin Xia and Florian J. Stadler

引用次数: 0

Synergistic healing of diabetic wounds through photothermal and peroxidase-like activity of heterogeneous Bi2S3/Au nanoparticles† 异质Bi2S3/Au纳米颗粒光热和过氧化物酶样活性对糖尿病伤口的协同愈合作用。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-10 DOI: 10.1039/D5TB00446B

Zilin Zhou, Lihui Meng, Yanru Hu, Meng Wang, Shuojie Cui, Panwen Liu, Yilin Yang, Zebin Chen and Qingzhi Wu

{"title":"Synergistic healing of diabetic wounds through photothermal and peroxidase-like activity of heterogeneous Bi2S3/Au nanoparticles†","authors":"Zilin Zhou, Lihui Meng, Yanru Hu, Meng Wang, Shuojie Cui, Panwen Liu, Yilin Yang, Zebin Chen and Qingzhi Wu","doi":"10.1039/D5TB00446B","DOIUrl":"10.1039/D5TB00446B","url":null,"abstract":"Bacterial resistance and biofilm formation around diabetic wounds are major challenges that make the wounds difficult to heal. It is crucial for diabetic wound healing to improve the microenvironment around the wounds. In this study, a novel strategy for diabetic wound healing is developed by combining the peroxidase (POD)-like enzyme activity and photothermal therapy (PTT) to protect against bacterial infections around the wounds. Heterogeneous bismuth sulfide/gold nanoparticles (Bi2S3/Au NPs) are synthesized through a two-step wet chemical route. Results show that Bi2S3/Au nanozymes display high POD-like enzyme activity and can effectively convert H2O2 into ˙OH. The antibacterial rate against S. aureus and E. coli bacteria is 99.8 ± 0.03% and 99.9 ± 0.01%, respectively, in the presence of H2O2 under near-infrared light (NIR) irradiation. Animal experiments on infected diabetic wounds demonstrate that the synergistic actions of the Bi2S3/Au NPs significantly inhibit the formation of biofilms caused by bacteria, and promote the deposition of collagen and the formation of epithelial and dermal tissue. This study provides a promising solution for innovative therapy of refractory diabetic wounds, which is of great significance for reducing the abuse of antibiotics and the production of drug-resistant bacteria.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 20","pages":" 5820-5831"},"PeriodicalIF":6.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colloidal gold immunochromatographic strips for the detection of kynurenine in clinical samples† 胶体金免疫层析试纸条用于临床样品中犬尿氨酸的检测。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-10 DOI: 10.1039/D5TB00188A

Jingqi Dong, Jialin Hu, Liqiang Liu, Aihua Qu, Hua Kuang and Chuanlai Xu

{"title":"Colloidal gold immunochromatographic strips for the detection of kynurenine in clinical samples†","authors":"Jingqi Dong, Jialin Hu, Liqiang Liu, Aihua Qu, Hua Kuang and Chuanlai Xu","doi":"10.1039/D5TB00188A","DOIUrl":"10.1039/D5TB00188A","url":null,"abstract":"Kynurenine (KYN), a metabolite of tryptophan, is currently receiving increasing attention as one of the biomarkers for clinical disease monitoring. To realize the determination of KYN in human plasma samples in the clinic, a specific monoclonal antibody (mAb) against KYN was prepared based on the structural characteristics of KYN. By optimizing the detection conditions, we obtained anti-KYN mAb 1G10 with a sensitivity of 143.66 ng mL−1, and established a colloidal gold immunochromatographic assay (CGCA) platform for the qualitative and quantitative analysis of KYN in human plasma samples, using CGCA strips to meet the needs of clinical testing. The recoveries of the strips for the determination of KYN in plasma samples were in the range of 85.22–99.72%, which were validated by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the results were in good agreement with the LC-MS/MS method, indicating that the accuracy of the prepared CGCA strips was high. Based on the characteristics of low cost, high throughput and good specificity, the test strips will be widely applicable for clinical determination.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 20","pages":" 5911-5918"},"PeriodicalIF":6.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-color reversible fluorescent carbon dots designed for dynamic monitoring of cellular superoxide anion radicals† 双色可逆荧光碳点设计的动态监测细胞超氧阴离子自由基†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-10 DOI: 10.1039/D5TB00099H

Dan Wang, Yanke Zhai, Yun Wang, Xu Fu, Yibing Ji and Ruijun Li

{"title":"Dual-color reversible fluorescent carbon dots designed for dynamic monitoring of cellular superoxide anion radicals†","authors":"Dan Wang, Yanke Zhai, Yun Wang, Xu Fu, Yibing Ji and Ruijun Li","doi":"10.1039/D5TB00099H","DOIUrl":"https://doi.org/10.1039/D5TB00099H","url":null,"abstract":"The superoxide anion radical (O2˙−) represents the primary reactive oxygen species generated in biological systems. Real-time monitoring of its dynamic fluctuations provides valuable insights into disease progression and enables early diagnosis of hepatic ischemia-reperfusion injury (HIRI). In this work, we developed a novel dual-color fluorescent carbon dot (CD) probe through a one-step hydrothermal synthesis for reversible O2˙− detection. The CDs demonstrated excellent sensitivity, dynamically detecting O2˙− concentrations ranging from 0 to 60 μM with a detection limit of 0.56 μM. The probe exhibited remarkable reversibility, maintaining stable performance through at least three complete oxidation–reduction cycles following glutathione (GSH) treatment. In practical applications, the CDs achieved 95.2–104% recovery rates when detecting O2˙− in serum samples. Cellular imaging experiments confirmed the probe's effectiveness in normal hepatocytes (LO2), showing clear reversible responses to O2˙− fluctuations. Application in a HIRI cell model revealed significant elevation of O2˙− levels and provided new evidence for its role in HIRI-related signaling pathways. This study not only presents an effective dual-color fluorescent probe for dynamic O2˙− monitoring but also establishes a versatile synthetic strategy that could be adapted for imaging other biologically relevant molecules in living cells.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 17","pages":" 5163-5170"},"PeriodicalIF":6.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00099h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bi13S18I2-based wearable photoelectrochemical biosensor for accurate monitoring of l-tyrosine in sweat as a diabetes biomarker† 基于bi13s18i2的可穿戴光电化学生物传感器，用于准确监测汗液中作为糖尿病生物标志物的l -酪氨酸。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-10 DOI: 10.1039/D5TB00095E

Kheibar Dashtian, Shaaker Hajati, Mehrorang Ghaedi, Marzie Rashid, Milad Zarghami Qaretapeh and Mehdi Rahimi-Nasrabadi

{"title":"A Bi13S18I2-based wearable photoelectrochemical biosensor for accurate monitoring of l-tyrosine in sweat as a diabetes biomarker†","authors":"Kheibar Dashtian, Shaaker Hajati, Mehrorang Ghaedi, Marzie Rashid, Milad Zarghami Qaretapeh and Mehdi Rahimi-Nasrabadi","doi":"10.1039/D5TB00095E","DOIUrl":"10.1039/D5TB00095E","url":null,"abstract":"The development of real-time, non-invasive, flexible wearable systems for biomarker monitoring is critical for advancing healthcare diagnostics. Herein, we present a flexible patch consisting of an ultrasensitive photoelectrochemical (PEC) biosensor integrated with a hydrophilic nonwoven fabric sweat-collecting pad for precise, unbiased, and high-performance monitoring of L-tyrosine (L-Tyr) in sweat. The innovative PEC sensor is based on the incorporation of Bi13S18I2 (BSI) as a photosensitive material, combined with a molecularly imprinted poly(m-phenylenediamine) (MIP) matrix as a biorecognition element. The developed biosensing photoelectrode exhibits an enhanced photoanodic response and improved incident photon-to-current efficiency (IPCE), attributed to optimized energy band alignment, increased visible-light absorption, efficient photo-induced charge separation, and transfer, extended electron–hole pair lifetime, and enhanced electron density and mobility. The platform offers an impressive linear detection range of 80 nM to 350 μM, with a detection limit as low as 24 nM, ensuring accurate and reliable L-Tyr monitoring, which is essential for diabetes care. The sensor exhibited high repeatability, long-term stability, and low cross-reactivity with potential interfering substances, further demonstrating its practicality for use in complex biological environments. This work marks a significant advancement in wearable diagnostic technology, providing a versatile platform for non-invasive biomarker monitoring. The ability to accurately detect L-Tyr in sweat makes this sensor a valuable tool for real-time health monitoring and diagnostics, opening new avenues for future innovations in PEC sensing and biosensing technologies.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 20","pages":" 5832-5844"},"PeriodicalIF":6.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel non-glutaraldehyde bioprosthetic heart valve construction strategy based on ATRP with enhanced anticoagulant and anti-calcification properties 基于ATRP的新型非戊二醛生物人工心脏瓣膜构建策略，具有增强抗凝血和抗钙化性能

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D4TB02800G

Hongxia Pu, Tao Yu, Canyu Wang, Zhizhuo Zhou, Da Zhu, Gaocan Li, Qinsheng Hu and Yunbing Wang

{"title":"Novel non-glutaraldehyde bioprosthetic heart valve construction strategy based on ATRP with enhanced anticoagulant and anti-calcification properties","authors":"Hongxia Pu, Tao Yu, Canyu Wang, Zhizhuo Zhou, Da Zhu, Gaocan Li, Qinsheng Hu and Yunbing Wang","doi":"10.1039/D4TB02800G","DOIUrl":"https://doi.org/10.1039/D4TB02800G","url":null,"abstract":"Minimally invasive transcatheter heart valve replacement (THVR) has provided a more convenient and effective means for curing heart valve diseases and defects. Bioprosthetic heart valves (BHVs), with superior hemodynamic performance and no need for long-term anticoagulation, have become the first choice for THVR in recent years. However, almost all the clinically used BHVs are crosslinked by glutaraldehyde, and due to calcification, inflammation, difficulty in endothelialization and other factors, the service cycle of these glutaraldehyde crosslinked BHVs is affected, thus limiting their further application. To avoid defects of these glutaraldehyde crosslinked BHVs, a novel non-glutaraldehyde synergistic crosslinking and modification strategy based on ATRP (atom transfer radical polymerization) has been developed in this study. Firstly, the decellularized porcine pericardium (D-PP) is grafted with an alkyl bromine group (Br-PP) to initiate the ATRP reaction, and then the four-arm double-bond substance is used to achieve crosslinked PP (PT-PP) through the in situ ATRP reaction to endow PT-PP with good mechanical properties. Finally, utilizing the advantage of controllable and active polymerization of ATRP, the surface of PT-PP can be further functionalized with sulfonic acid groups by the secondary polymerization to obtain the functionalized PP (PT-BS-PP). The feasibility of non-glutaraldehyde crosslinked and functionalized PPs has been further systematically evaluated as a potential leaflet material of BHVs. Good biocompatibility, superior anticoagulation properties, minimal immune rejection, enhanced endothelialization potential and excellent anti-calcification effects of the functionalized PT-BS-PP have been proven by in vitro and in vivo investigations, suggesting that PT-BS-PP is a great potential candidate for the further clinical applications of BHVs.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 19","pages":" 5643-5654"},"PeriodicalIF":6.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of cysteine-sensitive bimodal probes for in situ monitoring of early-stage pulmonary fibrosis progression and therapeutic effects† 半胱氨酸敏感双峰探针原位监测早期肺纤维化进展及治疗效果的研究。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D5TB00183H

Yang Wan, Wenxiu Li, Huayong Zhu, Sixin Ai and Weiying Lin

{"title":"Development of cysteine-sensitive bimodal probes for in situ monitoring of early-stage pulmonary fibrosis progression and therapeutic effects†","authors":"Yang Wan, Wenxiu Li, Huayong Zhu, Sixin Ai and Weiying Lin","doi":"10.1039/D5TB00183H","DOIUrl":"10.1039/D5TB00183H","url":null,"abstract":"Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by excessive extracellular matrix deposition and lung scarring, leading to impaired lung function, severe respiratory distress, and potentially fatal outcomes. Early diagnosis of PF is crucial for optimizing treatment strategies to improve patient prognosis. However, an activated near-infrared fluorescent (NIRF) and photoacoustic (PA) bimodal probe for non-invasive in situ imaging of PF is still lacking. In this study, we developed a novel cysteine-sensitive NIRF/PA dual-modal probe, MR-Cys, for in situ monitoring of early progression and the therapeutic response in a mouse model of PF. The probe MR-Cys selectively detects cysteine (Cys) levels in vivo, thereby activating both NIRF and PA signals. Using NIRF/PA dual-modal imaging technology, MR-Cys successfully tracked fluctuations in Cys levels within the PF mouse model. After treatment with nintedanib (OFEV), a notable decrease in both PA and NIRF signal intensities was observed in the treated mice, indicating that MR-Cys can be used to assess the therapeutic efficacy for PF. Therefore, MR-Cys not only holds great promise for early detection of pulmonary fibrosis progression, but also offers a precise monitoring tool for the optimization of personalized treatment plans.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 17","pages":" 5051-5057"},"PeriodicalIF":6.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles† 通过表面固定化负载抗生素的多肽多室胶束†增强抗菌保护

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D5TB00246J

Shabnam Tarvirdipour, S. Narjes Abdollahi, Joachim Köser, Maryame Bina, Cora-Ann Schoenenberger and Cornelia G. Palivan

{"title":"Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles†","authors":"Shabnam Tarvirdipour, S. Narjes Abdollahi, Joachim Köser, Maryame Bina, Cora-Ann Schoenenberger and Cornelia G. Palivan","doi":"10.1039/D5TB00246J","DOIUrl":"https://doi.org/10.1039/D5TB00246J","url":null,"abstract":"The escalating global threat of antibiotic-resistant bacterial infections, driven by biofilm formation on medical device surfaces, prompts the need for innovative therapeutic strategies. To address this growing challenge, we develop rifampicin-loaded multicompartment micelles (RIF-MCMs) immobilized on surfaces, offering a dual-functional approach to enhance antimicrobial efficacy for localized therapeutic applications. We first optimize the physicochemical properties of RIF-MCMs, and subsequently coat the optimal formulation onto a glass substrate, as confirmed by quartz crystal microbalance and atomic force microscopy. Surface-immobilized RIF-MCMs facilitate sustained antibiotic release in response to biologically relevant temperatures (37 °C and 42 °C). In addition, their heterogeneous distribution enhances the surface's roughness, contributing to the antibacterial activity through passive mechanisms such as hindering bacterial adhesion and biofilm formation. In vitro antimicrobial testing demonstrates that RIF-MCM-modified surfaces achieve a 98% reduction in Staphylococcus aureus viability and a three-order-of-magnitude decrease in colony formation compared to unmodified surfaces. In contrast, RIF-MCMs exhibit minimal cytotoxicity to mammalian cells, making them suitable candidates for medical device coatings. Our dual-function antimicrobial strategy, combining sustained antibiotic release and enhanced surface roughness, presents a promising approach to locally prevent implant-associated infections and biofilm formation.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 18","pages":" 5365-5379"},"PeriodicalIF":6.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00246j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-strength bone polyurethane adhesive with rapid curing for bone tissue injury repair† 高强度骨聚氨酯粘合剂，可快速固化，用于骨组织损伤修复。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D4TB02390K

Xuehua Zhao, Jinju Ding, Chengkai Xuan, Jianing Liao and Xuetao Shi

{"title":"High-strength bone polyurethane adhesive with rapid curing for bone tissue injury repair†","authors":"Xuehua Zhao, Jinju Ding, Chengkai Xuan, Jianing Liao and Xuetao Shi","doi":"10.1039/D4TB02390K","DOIUrl":"10.1039/D4TB02390K","url":null,"abstract":"Bone tissue adhesives have advantages such as preventing stress shielding and secondary surgical infections, fixing small bone fragments, easing operations, and enhancing wound adaptability. These methods can be applied for the traumatic repair of comminuted fractures. Currently, commercial tissue adhesives fail to meet the biological safety and mechanical strength requirements of bone tissue adhesives. To address this situation, we developed and screened a rapidly cured high-strength polyurethane bone adhesive. Research has shown that polyurethane bone adhesives have shorter curing times (236 s to 273 s), higher tensile moduli (425.88 MPa to 666.38 MPa), compressive moduli (214.67 MPa to 450.66 MPa), and adhesive strengths (0.92 MPa to 5.86 MPa). It can withstand cyclic stresses ranging from 0.01 MPa to 1 MPa for 1000 cycles. Polyurethane bone adhesive surpasses the inadequate adhesive performance and in vivo repair functionality of existing commercial bone cements, achieving effective repair of bone tissue injuries. Furthermore, we developed an unsaturated ester-modified secondary amine curing agent based on the Michael addition reaction, enabling rapid and safe curing of bone polyurethane adhesives and thereby providing a novel and effective repair solution for bone tissue injuries.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 17","pages":" 5150-5162"},"PeriodicalIF":6.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0