Journal of Materials Chemistry B最新文献

{"title":"A biomimetic dual-targeting nanomedicine for pancreatic cancer therapy†","authors":"Guihua Zhou, Yuan Zhang, Zhiwei Cai, Hongfei Yao, Meng Liu, Chongyi Jiang and Zhen Cheng","doi":"10.1039/D4TB02206H","DOIUrl":"10.1039/D4TB02206H","url":null,"abstract":"<p >The physiological characteristics of pancreatic cancer (PC) involve the interplay between tumor cells, cancer-associated fibroblasts (CAF) and the extracellular matrix (ECM). This intricate microenvironment contributes to the cancer's resistance to conventional chemoradiotherapy and its poor prognosis. Carbon monoxide (CO), a promising molecule in gas therapy, can effectively penetrate solid tumors and induce tumor cell apoptosis at high concentrations. However, precise dosing control remains a significant challenge in the administration of exogenous CO, and its inherent toxicity at elevated concentrations presents substantial barriers to clinical translation. In this study, we developed a novel biomimetic nanomedical drug delivery system capable of simultaneously targeting CAF and PC tumor cells, degrading the ECM, and inhibiting tumor growth. The strategy integrates iron carbonyl (FeCO), an anti-cancer agent, and losartan (Lo), a drug that degrades tumor matrix, into a biodegradable nanomaterial—mesoporous polydopamine (MPDA). The resulting nanoparticles are then coated with CAF cell membranes (CAFM) and functionalized with plectin-1 targeted peptide (PTP), a molecule that targets PC cells, to construct the (Lo + FeCO)@MPDA@CAFM-PTP nanomedicine. This system utilizes the homologous adhesion properties of CAF membranes to target CAFs, delivering Lo to degrade the ECM. Following ECM degradation, the nanomedicine penetrates further to bind to PC tumor cells <em>via</em> PTP. Then anti-cancer drug FeCO is released to react with the excessive reactive oxygen species (ROS) in PC tumor cells to produce high concentrations of CO, effectively inducing tumor cell apoptosis. The (Lo + FeCO)@MPDA@CAFM-PTP nanomedicine demonstrated significant cytotoxicity against Panc-1 cells <em>in vitro</em> and effectively inhibited PC tumor growth <em>in vivo</em>. This innovative approach holds great promise for advancing pancreatic cancer treatment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3716-3729"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a novel polyelectrolyte complex nanocomposite of modified chitosan and karaya gum for co-delivery of 5-fluorouracil and curcumin for cancer therapy","authors":"Rakshitha Anjar, Manohar Mahadev, Rompicherla Narayana Charyulu and Vishalakshi Badalamoole","doi":"10.1039/D4TB02354D","DOIUrl":"10.1039/D4TB02354D","url":null,"abstract":"<p >Combination chemotherapy is a relatively recent and preferred method for cancer treatment. Sustained delivery of dual drugs can be achieved with a suitable matrix. In the present work, a pH-responsive polyelectrolyte complex (PEC) of trimethylchitosan and carboxymethylkaraya gum containing silver nanoparticles (SNps) has been developed as a matrix material for co-delivery of the drugs, 5-fluorouracil (5-Fu) and curcumin (Cur). The experimental conditions have been optimized for high yield and high swelling of the PEC nanocomposite. <small>¹</small>H-NMR, FT-IR, FE-SEM, P-XRD, HR-TEM, EDS, TGA techniques and zeta potential measurements have been employed in the physico-chemical characterization of the nanocomposite material. The presence of SNps with an average diameter of 16.57 ± 1.25 nm influenced the surface structure and hydrophilicity of the PEC. The swelling study indicated higher swelling at pH 7.4 than at pH 1.2. The two drugs, 5-Fu and Cur, were successfully entrapped and released from the nanocomposite in a sustained manner. Cytotoxicity studies performed with the MCF-10A cell line confirmed the biocompatibility of the nanocomposite and those with the MCF-7 cell line indicated the synergistic effect of the dual drugs in controlling cancer cell growth. The overall study indicates the usefulness of the PEC nanocomposite made from modified polysaccharides, chitosan and karaya gum as a promising material for the development of a dual drug delivery system for cancer treatment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3602-3617"},"PeriodicalIF":6.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of silk fibroin-based composite films in biomedicine and biotechnology","authors":"Ke Ma, Zhi-Feng Wu, Ke-Zheng Chen and Sheng-Lin Qiao","doi":"10.1039/D4TB02616K","DOIUrl":"10.1039/D4TB02616K","url":null,"abstract":"<p >Silk fibroin has garnered significant attention as a natural biomaterial due to its exceptional biocompatibility, tunable water solubility, optical transparency and high thermal stability. In recent years, silk fibroin films have gained prominence for their ease of fabrication and unique properties. However, their intrinsic brittleness limits broader applicability in certain fields. To overcome this challenge, researchers have developed various strategies, including physical blending, chemical modification, and genetic engineering, to improve key attributes such as mechanical strength, antimicrobial activity, and electrical conductivity. These advancements have significantly broadened the utility of silk fibroin films in diverse biomedical applications. This review provides an in-depth analysis of recent progress in silk fibroin-based composite films, emphasizing their applications in bone regeneration, wound healing, and health monitoring. Modified silk fibroin composites are highlighted for their superior material properties and enhanced functional potential in these domains. Additionally, this review discusses future research directions, offering valuable insights into pathways for further innovation and practical implementation. With continued advancements, silk fibroin composite films are poised to make transformative contributions to the fields of biomedicine and biotechnology.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3494-3515"},"PeriodicalIF":6.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1,4-Bis(2-hydroxyethyl)piperazine-derived water-dispersible and antibacterial polyurethane coatings for medical catheters†","authors":"Anchal Gupta, Simran Kaur Rainu, Manleen Kaur, Mahipal Meena, Neetu Singh and Josemon Jacob","doi":"10.1039/D4TB02227K","DOIUrl":"10.1039/D4TB02227K","url":null,"abstract":"<p >To prolong usage and mitigate infections associated with bacterial colonization on medical catheters, the development of water-dispersible polyurethane (PU) coatings with bactericidal properties is desirable. With this objective, we have formulated polyurethane coatings that exhibit both antibacterial activity and water dispersibility. A piperazine-based diol, 1,4-bis(2-hydroxyethyl)piperazine (<strong>HEPZ</strong>), was synthesized and used as a chain extender in PU synthesis. The PUs were prepared using hexamethylene diisocyanate (HDI), 4,4′-methylene diphenyl diisocyanate (MDI), polyethylene glycol (PEG<small>₆₀₀</small>), and polypropylene glycol (PPG<small>₄₀₀</small>), resulting in a series of polyurethanes (<strong>PU1–PU4</strong>). MDI-containing PUs showed superior tensile strength (3.2–3.6 MPa) and elongation (67–70%) attributable to their higher aromatic content. The PEG<small>₆₀₀</small>-containing PUs (<strong>PU1</strong> and <strong>PU3</strong>) were alkylated using methyl iodide (MeI) to varying degrees whereby a significant reduction in contact angle from ∼82° to ∼62° was observed, indicating enhanced hydrophilicity. <strong>MPU3-D</strong> with 72.5% methylation demonstrated the most stable water dispersion with a particle size of ∼190.8 nm and a zeta potential of +49.0 mV. <em>In vitro</em> cytocompatibility studies further revealed that methylated <strong>PU3</strong> exhibited higher compatibility (80–90%) compared to methylated <strong>PU1</strong> (30–40%). The hemolysis test showed the non-hemolytic behavior of <strong>MPU3-D</strong> films with a % hemolysis of 0.4 ± (0.2)% making it suitable for coating on medical devices. Additionally, <strong>MPU3-D</strong> films also demonstrated antibacterial activity against Gram-negative (<em>E. coli</em>) and Gram-positive (<em>S. aureus</em>) bacteria, with zones of inhibition measuring 7 mm and 8 mm, respectively. Also, water-dispersible <strong>MPU3-D</strong>-based coatings with a hardness of ∼75 A and a thickness of ∼17 μm (as observed through FESEM) showed strong adhesion to PVC catheters, exhibiting an adhesion strength of 4B rating. Our results suggest that water-dispersible polyurethane coatings with antibacterial properties are promising materials to reduce catheter-associated infections and enhance patient care.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 10","pages":" 3350-3364"},"PeriodicalIF":6.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Room temperature operated flexible MWCNTs/Nb2O5 hybrid breath sensor for the non-invasive detection of an exhaled diabetes biomarker†","authors":"Gulshan Verma, Sonu Sarraf, Aviru K. Basu, Pranay Ranjan and Ankur Gupta","doi":"10.1039/D4TB02644F","DOIUrl":"10.1039/D4TB02644F","url":null,"abstract":"<p >Advancements in diabetes management increasingly rely on non-invasive monitoring of biomarkers present in exhaled breath. This study introduces a novel room temperature operated flexible acetone sensing platform, leveraging a hybrid material composed of multi-walled carbon nanotubes (MWCNTs) and niobium oxide (Nb<small>₂</small>O<small>₅</small>). The platform demonstrates sensitivity and selectivity towards acetone, a prominent biomarker of diabetes, offering promise for real-time health monitoring applications. The sensor exhibited a characteristic feature of fast response (25 s) and recovery times (46 s) at 50 ppm, good selectivity, and stability with a detection limit of 330 ppb. Additionally, the sensor's characteristic features were collected, and four different machine learning (ML) algorithms were applied to visualize and classify the gases with good quantification. Out of all algorithms, the random forest (RF) algorithm demonstrates the best performance. Furthermore, regression modelling was also used to quantitatively predict the gas concentration. In addition, the sensor was shown to distinguish between signals from simulated diabetic and healthy breath samples. These sensing performances indicate that the breath sensor has practical applications that could potentially provide a non-invasive monitoring method for diabetic patients.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 10","pages":" 3460-3470"},"PeriodicalIF":6.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural aspects of dimeric prodrug-based carrier-free nanomedicines for tumor chemotherapy†","authors":"Chen Yang and Peng Liu","doi":"10.1039/D4TB02850C","DOIUrl":"10.1039/D4TB02850C","url":null,"abstract":"<p >The effect of flexible linker length in dimeric prodrugs was explained through their aggregation structures, as revealed by molecular dynamics simulations. The results indicated that the aggregation structure of the dimeric prodrug was controlled by the molecular structure (mainly flexible linkers) as an internal factor and the fabrication methods as an external factor.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 10","pages":" 3292-3294"},"PeriodicalIF":6.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From window panes to bone regeneration: structure, viscosity and bioactivity of soda lime silicate glasses†","authors":"Zhaorui Jin, Daniel R. Neuville, Coraline Chartier, Pavel Kachanov, Scott Kroeker, Stéphane Gin, Jincheng Du and Delia S. Brauer","doi":"10.1039/D4TB02414A","DOIUrl":"10.1039/D4TB02414A","url":null,"abstract":"<p >Silicate glasses are not only used for everyday items such as windows or drinking glasses. By altering their composition, one can adjust their properties to allow them to become degradable and help to regenerate bone. Here, we investigate how compositional changes from conventional soda lime silicate glasses to low-silica content compositions affect their structure and properties. Results show that silicate network polymerisation, known as network connectivity, controls many properties, including viscosity, which is relevant for processing, and reactivity in aqueous environments. Correlating our data with <em>in vivo</em> results from the literature, we show how changes in silicate network connectivity as represented by their modifier content and non-bridging oxygen concentration, allow us to turn bioinert soda lime silicate glasses into bioactive materials to enhance bone formation.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 10","pages":" 3448-3459"},"PeriodicalIF":6.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02414a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luminescent bio-sensors via co-assembly of hen egg white lysozyme with Eu3+/Tb3+-complexes†","authors":"Min Zhang, Miao Qiu, Zengkun Li, Rui Xu, Yao Wang, Wei Wang, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore and Jianguo Tang","doi":"10.1039/D4TB01766H","DOIUrl":"10.1039/D4TB01766H","url":null,"abstract":"<p >Protein crystals have advantageous properties as framework materials, such as porosity and organized, high-density functional groups with the potential for guest specificity. Thus, protein crystal materials open up vast opportunities for fluorescent species doping and drug sensing. In this work, we explore this frontier by combining two lanthanide complexes with hen egg white lysozyme (HEWL) and directly obtaining co deposited structures in one step using an anti-solvent method different from the previous two-step method. Cross-linking of the protein was achieved using glutaraldehyde, ensuring the stability of the assembly in diverse solvent environments. The use of glutaraldehyde achieved protein cross-linking, ensuring the stability of the components in various solvent environments, including no leakage of fluorescent substances in ultrapure water and anhydrous ethanol. Differential fluorescence quenching effects of amino acids on the two doped luminescent complexes were observed. Introduction of amino acids, varying in concentration and type, resulted in distinct fluorescence enhancement or quenching effects on the protein assembly loaded with the complexes, and the detection results are reflected through different fitting equations and parameters. By exploring the application of this hybrid material for amino acid detection, this work lays the groundwork for broader applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3198-3208"},"PeriodicalIF":6.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Development of a tannic acid- and silicate ion-functionalized PVA–starch composite hydrogel for in situ skeletal muscle repairing","authors":"Longkang Li, Huipeng Li, Zhentian Diao, Huan Zhou, Yanjie Bai and Lei Yang","doi":"10.1039/D5TB90025E","DOIUrl":"10.1039/D5TB90025E","url":null,"abstract":"<p >Correction for ‘Development of a tannic acid- and silicate ion-functionalized PVA–starch composite hydrogel for <em>in situ</em> skeletal muscle repairing’ by Longkang Li <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2024, <strong>12</strong>, 3917–3926, https://doi.org/10.1039/D3TB03006G.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 8","pages":" 2875-2876"},"PeriodicalIF":6.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90025e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications†","authors":"Xue Yan, Li-Xin Gao, Zi-Tong Cao, Su-Ya Gan, Yi-Qiu Fu, Jia Li, Da-Jun Xiang, Yu-Bo Zhou and Wen-Long Wang","doi":"10.1039/D4TB02524E","DOIUrl":"10.1039/D4TB02524E","url":null,"abstract":"<p >Although the benzimidazole moiety is a versatile heterocyclic unit that has been widely applied in optical materials and medicinal chemistry, there are few bifunctional small-molecule benzimidazole derivatives with bio-activity and fluorescence. In this work, a series of novel benzimidazole-salicylic acid molecules were designed and synthesized; their optical properties were evaluated and their potential biological application was explored. The representative compound <strong>5q</strong> exhibited excellent fluorescence properties, displaying blue imaging in HeLa cells and zebrafish. Additionally, it exhibited high selectivity for Fe<small>³⁺</small> ions and demonstrated a notable inhibitory activity with IC<small>₅₀</small> = 6.86 ± 2.82 μM against SHP1<small>^PTP</small>. Further effort was applied to explore the potential capability of compound <strong>5q</strong> to reactivate the activity of SHP1 when inhibited by Fe<small>³⁺</small> ions, indicating that compound <strong>5q</strong> could be a fluorescent modulator to adjust SHP1 enzyme activity in biological systems.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3633-3643"},"PeriodicalIF":6.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}