Journal of Materials Chemistry B最新文献

{"title":"Lactate-sensitive nanomachines for enzyme-controlled drug delivery in cancer therapy","authors":"Marta González-Jiménez, Teresa Moreno, Beatriz Mayol, Esther Garcia-Díez, Soraya Salido, Alfredo Sánchez-Sánchez, Paloma Martinez-Ruiz, Narcisa Martínez-Quiles, Diana Vilela and Reynaldo Villalonga","doi":"10.1039/D6TB00119J","DOIUrl":"10.1039/D6TB00119J","url":null,"abstract":"<p >Here, we report the preparation of a novel enzyme-powered nanomachine for a drug delivery system based on mesoporous silica nanoparticles capped with a cyclodextrin-lactate oxidase (CD-LOx) complex, which enables controlled cargo release triggered by the presence of <small>L</small>-lactate in the tumor microenvironment. To this end, mesoporous silica nanoparticles were functionalized with diphenylethane-1,2-dione moieties and subsequently loaded with a cargo molecule. In parallel, a CD-LOx complex was prepared to act as a capping agent through supramolecular interactions, enabling controlled release of the encapsulated molecules in response to <small>L</small>-lactate. These nanodevices were first evaluated using [Ru(bpy)<small>₃</small>]Cl<small>₂</small>, as a model cargo, to confirm the efficiency and specificity of the gating mechanism. Subsequently, the nanomachines were loaded with the anticancer drug doxorubicin and tested in cell culture experiments at a concentration of 50 µg L<small>⁻¹</small>. The results showed the best therapeutic response after 24 hours of incubation in the presence of 25 mM <small>L</small>-lactate, confirming that lactate-triggered H<small>₂</small>O<small>₂</small> generation efficiently activates the molecular gates and promotes targeted drug release within the cellular environment. This work demonstrates the development of an autonomous lactate-responsive drug delivery system that enables selective and controlled drug release in tumor environments with high <small>L</small>-lactate levels.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 23","pages":" 7244-7252"},"PeriodicalIF":6.2,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifying biological heart valve leaflets using anti-fouling polymers incorporated with metal–phenolic networks for enhanced anti-thrombosis, anti-calcification and endothelialization","authors":"Lepeng Chen, Kunpeng Liu, Hui Yan, Tiantian Zheng, Chen Li, Qinsheng Hu, Rifang Luo and Yunbing Wang","doi":"10.1039/D6TB00082G","DOIUrl":"10.1039/D6TB00082G","url":null,"abstract":"<p >Promoting endothelialization of the bioprosthetic valve is necessary to improve the performance of the valve, and good hemocompatibility ensures adequate time for the endothelialization process. In this work, metal–phenolic networks (MPNs), formed by the coordination interactions between (−)-epigallocatechin gallate (EGCG) and copper ions (Cu<small>²⁺</small>), were incorporated into the zwitterionic polymer modified glutaraldehyde crosslinked leaflets. The modified valve leaflets can prevent thrombosis and calcification mainly due to the antifouling zwitterionic polymer, and can induce enhanced endothelialization potential <em>via</em> the generation of nitric oxide. Bioprosthetic leaflets incorporating EGCG and Cu<small>²⁺</small>, as well as zwitterionic copolymers, contributed to the growth of endothelial cells in co-culture experiments, achieving a proliferation improvement of up to 50% compared to glutaraldehyde-crosslinked valves. Subcutaneous implantation confirmed that the modified leaflets exhibit great anti-calcification ability (with a 90% reduction in calcium deposition relative to glutaraldehyde-crosslinked valves) and reduced inflammatory response. The valve leaflets modified by EGCG, Cu<small>²⁺</small> and zwitterionic polymers have antithrombosis and anti-calcification properties and pro-endothelialization potential.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7647-7658"},"PeriodicalIF":6.2,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular peptide hydrogels for the treatment of ocular diseases: from tissue replacements to drug delivery systems","authors":"Daowei Xia, Wenting Li, Jing Xie, Dongdong Zhou and Hao Su","doi":"10.1039/D6TB00761A","DOIUrl":"10.1039/D6TB00761A","url":null,"abstract":"<p >Supramolecular peptide hydrogels (SPHs), a unique class of dynamic three-dimensional networks formed by self-assembly of peptides, have demonstrated strong potential for ocular tissue replacement and drug delivery in ophthalmic applications. On the one hand, their mechanical and physiochemical properties can be precisely tailored <em>via</em> rational design of peptides to emulate native ocular tissues. On the other hand, the intrinsic dynamic features of SPHs enable efficient encapsulation of commercial drugs and incorporation of stimuli-responsive or targeting moieties, which in turn facilitate ocular barrier penetration and enhance therapeutic efficacy. In this review, we systematically summarize recent advances of the use of SPHs in ocular disease treatment, focusing on their design principles and two key application aspects: ocular tissue substitutes (for vitreous and corneal repair) and drug delivery systems targeting prevalent ocular pathologies, including dry eye disease, corneal neovascularization, bacterial keratitis, anterior uveitis, diabetic retinopathy, and age-related macular degeneration. These findings highlight the promising potential of SPHs as next-generation biomaterials for precision ophthalmic therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 23","pages":" 7105-7123"},"PeriodicalIF":6.2,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bismuth hybrid halide with dual inhibition against α-amylase and acetylcholinesterase probed by structural, vibrational, and theoretical analysis","authors":"Assala Bahloul, Mehdi Messaad, Sirine Smaoui, Bassem Khemakhem and Mohamed Abdelhedi","doi":"10.1039/D5TB02912K","DOIUrl":"10.1039/D5TB02912K","url":null,"abstract":"<p >This study presents the comprehensive synthesis, structural characterization, and biological evaluation of a novel zero-dimensional bismuth(<small>III</small>)-based hybrid material, (C<small>₇</small>H<small>₁₀</small>NO)<small>₄</small>[BiCl<small>₆</small>]·Cl·H<small>₂</small>O. Single-crystal X-ray diffraction analysis confirmed its crystallization in the monoclinic centrosymmetric space group <em>C</em>2/<em>c</em>, revealing a structure composed of discrete [BiCl<small>₆</small>]<small>³⁻</small> octahedra, protonated <em>p</em>-anisidinium cations, a free chloride ion, and a water molecule. Complementary SEM-EDS and PXRD analyses confirmed phase purity, distinct anisotropic needle-like morphology, and correct stoichiometry. The crystal packing is stabilized by an extensive network of strong N–H⋯Cl, N–H⋯O, and O–H⋯Cl hydrogen bonds, alongside weaker C–H⋯π and n → π interactions, as quantitatively decoded through Hirshfeld surface analysis. Combined experimental (FT-IR, Raman) and theoretical (DFT) vibrational studies provided unequivocal assignments of all characteristic modes, confirming the molecular structure and elucidating the distortion of the inorganic anion induced by the stereochemically active 6s<small>²</small> lone pair on Bi(<small>III</small>) and external hydrogen-bonding forces. In addition, solution stability and structural integrity were investigated using UV-visible spectroscopy and liquid chromatography–mass spectrometry, confirming the preservation of the hybrid framework over time. Most significantly, enzymatic inhibition assays demonstrated the compound's exceptional dual bioactivity. It exhibited potent inhibition against acetylcholinesterase (AChE, IC<small>₅₀</small> = 1.96 ± 0.1 mM) and α-amylase (IC<small>₅₀</small> = 0.27 ± 0.014 mM), outperforming its antimony(<small>III</small>) analogue by factors of 2 and 15, respectively, and the organic precursor <em>p</em>-anisidine by a factor of 14. This integrated study underscores the role of bismuth incorporation in enhancing functional properties, positioning this hybrid as a highly promising candidate for applications in optoelectronics, as a tailored functional material, and as a next-generation bioactive agent for therapeutic and agrochemical applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 23","pages":" 7224-7243"},"PeriodicalIF":6.2,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cucumber-derived exosome-like nanovesicles encapsulating epigallocatechin gallate for skin depigmentation: molecular docking, stability, and efficacy in B16/F10 cells and zebrafish","authors":"Li Tao, Ping Wang, Mengying Zhang, Wenyue Zhang, Rui Zhang, Junhao Tao, Mingyuan Chen, Jing Wu, Kawagishi Hirokazu and Peishi Feng","doi":"10.1039/D6TB00396F","DOIUrl":"10.1039/D6TB00396F","url":null,"abstract":"<p >To address the challenges of instability and low bioavailability that limit the application of (−)-epigallocatechin gallate (EGCG) as a whitening agent, we engineered a cucumber-derived exosome-like nanovesicle (CEV) as a synergistic nanocarrier. A hybrid isolation method combining polyethylene glycol precipitation with electrophoretic dialysis (PED) was established to obtain high-purity CEVs. The resulting EGCG-loaded CEVs (EGCG@CEVs) achieved 95.43% encapsulation efficiency with enhanced stability and a sustained release profile. Metabolomics and network pharmacology identified the STAT3/MAPK signaling axis as the primary target, a mechanism subsequently validated in B16F10 melanocytes and zebrafish models. Compared with free EGCG, EGCG@CEVs significantly decreased tyrosinase activity and melanin production. With the stable EGCG@CEV system, the ERK-STAT3-MITF pathway can be regulated, potentially functioning as a plant-based cosmetic system.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 22","pages":" 7034-7051"},"PeriodicalIF":6.1,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic mechanical cues from hydrogels promote osteogenesis via the YAP signaling pathway","authors":"Hai Liu, Lulong Zhao, Weilun Pan, Songlang Liu, Hongxing Liao, Jun Hu and Liqiong Liao","doi":"10.1039/D6TB00164E","DOIUrl":"10.1039/D6TB00164E","url":null,"abstract":"<p >The native bone matrix stiffens dynamically during development, presenting a critical mechanical cue that static biomaterials cannot effectively mimic. To address this, a photo-tunable dynamic stiffening hydrogel was developed using a dual-crosslinking strategy, combining physical crosslinking through freeze–thaw cycles and UV-triggered thiol–ene photo-click crosslinking. This photo-tunable dynamic stiffening hydrogel significantly promoted the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) <em>in vitro</em> and enhanced the repair of critical-sized calvarial defects <em>in vivo</em>. Mechanistic studies revealed that the pro-osteogenic effect is mediated through the activation of the Yes-associated protein (YAP) signaling pathway, as evidenced by its nuclear translocation. Our findings underscore the importance of temporal mechanical cues in bone regeneration and offer a novel biomimetic strategy for bone tissue engineering.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 22","pages":" 6890-6904"},"PeriodicalIF":6.1,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifouling and rechargeable antibacterial polyurethane modified with N-halamine for dental unit waterlines","authors":"Cheng Ni, Min Xing, Yifan Gui, Ling Zhang, Wenhao Qian, Xiangyang Shi and Rui Guo","doi":"10.1039/D6TB00480F","DOIUrl":"10.1039/D6TB00480F","url":null,"abstract":"<p >Bacterial contamination and biofilm formation in dental unit waterlines (DUWLs) present significant public health risks and economic burdens. Although standard chemical disinfection is commonly employed to sterilize DUWLs, it often fails to eradicate biofilms on the surfaces of polyurethane (PU). To address this, we developed a dual-functional PU surface possessing both antifouling and rechargeable antibacterial properties. The surface modification involved the initial conjugation of 1,6-diisocyanatohexane (HDI), followed by the sequential covalent grafting of polyethylene glycol (PEG) and 5,5-dimethylhydantoin (DMH). The resulting PU-HDI-PEG-DMH exhibited high hydrophilicity and reduced protein adsorption by over 50%. After chlorination, PU-HDI-PEG-DMH-Cl displayed durable biocidal efficacy through <em>N</em>-halamine-mediated contact- and release-killing mechanisms. Notably, this antibacterial capacity was fully rechargeable <em>via</em> standard clinical sterilization protocols. Therefore, this strategy offers a promising and sustainable solution to inhibit bacterial contamination and enhance the biosafety of DUWLs.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 21","pages":" 6510-6517"},"PeriodicalIF":6.1,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocyte purification column using thermoresponsive glycopolymer-modified silica beads","authors":"Kenichi Nagase and Junnosuke Matsuda","doi":"10.1039/D6TB00422A","DOIUrl":"10.1039/D6TB00422A","url":null,"abstract":"<p >Regenerative medicine involving hepatocytes holds promise as a therapeutic strategy for liver diseases. The clinical application of this approach requires a reliable technique for hepatocyte isolation. In this study, we developed a cell separation column that employs a thermoresponsive glycopolymer to isolate hepatocytes through temperature modulation. Silica beads were coated with poly(<em>N-p</em>-vinylbenzyl-<em>O</em>-β-<small>D</small>-galactopyranosyl-1→4-<small>D</small>-guliconamide)-<em>b</em>-poly(<em>N</em>-isopropylacrylamide) (PVLA-<em>b</em>-PNIPAAm) <em>via</em> atom transfer radical polymerization and were used as packing material for the column. The modified beads were characterized using scanning electron microscopy, CHN elemental analysis, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy. Nine columns were fabricated by altering the PNIPAAm and PVLA chain lengths of PVLA-<em>b</em>-PNIPAAm. Evaluation of the elution characteristics of HepG2 cells revealed that columns with intermediate PVLA and PNIPAAm chain lengths exhibited temperature-dependent cell retention and elution. This column enabled the separation of HepG2 cells from contaminating RAW264.7 cells by adjusting the temperature. The recovered HepG2 cells retained high levels of activity. Collectively, these findings indicate that the developed column enables efficient separation of hepatocytes solely through temperature modulation.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7499-7511"},"PeriodicalIF":6.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/tb/d6tb00422a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds","authors":"Madhusmita Sahoo, Tonmoy Banerjee, Shraddha Virkar, Sneha Das, Swati Biswas and Debirupa Mitra","doi":"10.1039/D6TB00543H","DOIUrl":"10.1039/D6TB00543H","url":null,"abstract":"<p >Bacterial infection remains a major challenge in wound management, often leading to delayed healing, prolonged treatment, and increased healthcare costs. Antimicrobial dressings provide an effective approach to prevent and control wound infections, thereby supporting faster wound repair. Although many antimicrobial dressings are commercially available and widely studied, most are either loaded with antibiotics, which raises concerns about antibiotic resistance, or contain silver nanoparticles (Ag NPs), which increase the overall cost. Therefore, this work presents a cost-efficient strategy for developing a highly effective antimicrobial wound dressing by functionalizing medical-grade cotton gauze (CG) with two polysaccharides, <em>N</em>-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC) and dextran, followed by <em>in situ</em> immobilization of copper nanoparticles (Cu NPs). To establish a structure–activity relationship, the immobilized Cu NPs were systematically characterized using SEM, EDX, XPS, and AAS to evaluate the influence of particle size, Cu loading, and release behaviour on antibacterial performance. The modified gauze demonstrated excellent antibacterial activity, where the lowest Cu-loaded sample with smaller nanoparticles achieved a ∼4-log reduction in <em>S. aureus</em>, while the highest Cu-loaded gauze (average size ∼700 nm) achieved &gt;5-log reduction. In addition, the dressing demonstrated sustained Cu release and high cytocompatibility, and supported cell migration <em>in vitro</em>. Importantly, <em>in vivo</em> studies using the <em>S. aureus</em>-infected rat wound model revealed that the modified CG dressing outperformed a commercial anti-infective dressing by significantly reducing bacterial load, accelerating tissue regeneration, and suppressing inflammation. Overall, this study provides important insights into Cu NP-functionalized CG and highlights its potential as an effective and affordable antimicrobial dressing for the management of infected wounds.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 23","pages":" 7179-7194"},"PeriodicalIF":6.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network modulation enables 3D-printed citrate-based polymer scaffolds with broadly tunable mechanical performance for regenerative engineering","authors":"Ni Chen, Nolan Schlessman, Rao Fu and Yonghui Ding","doi":"10.1039/D6TB00602G","DOIUrl":"10.1039/D6TB00602G","url":null,"abstract":"<p >Biomaterials with tunable mechanical properties and tissue-mimetic structural features are critical for diverse biomedical applications. Photopolymerizable citrate-based polymers, such as methacrylate polydiolcitrate (mPDC), enable high-resolution fabrication of biodegradable scaffolds <em>via</em> light-based 3D printing for regenerative engineering. However, their broader utility is limited by intrinsic brittleness and restricted mechanical tunability, associated with highly crosslinked heterogeneous polymer networks. To overcome these limitations, we report facile network-engineering strategies that modulate crosslinking density and network topology through incorporation of acrylate-based reactive diluents and/or a thiol-based chain transfer agent, 3,6-dioxa-1,8-octanedithiol (DOD). This approach yields substantially improved and broadly tunable mechanical properties with Young's modulus spanning 6.9–133.5 MPa, ultimate tensile strength ranging from 1.8 MPa to 18.3 MPa, and strain at break varying from 14.2% to 60.6%. Notably, incorporation of isobornyl acrylate (IBOA) alone increased stiffness and toughness, resulting in a 3.6-fold increase in Young's modulus (50.1 <em>vs.</em> 14.0 MPa) and a 2.8-fold increase in strain at break (39.4% <em>vs.</em> 14.2%). Furthermore, the combined use of IBOA and DOD enabled a 4-fold increase in ductility (up to 60.6% strain at break) while maintaining comparable stiffness. All mPDC composite formulations retained good printability, exhibited tunable biodegradability, and supported cell viability. Importantly, these materials enabled application-specific performance in 3D-printed scaffolds: meniscus scaffolds supported human chondrocyte growth and fibrochondrogenic matrix deposition, while vascular stents supported endothelial monolayer formation. Collectively, this work establishes a versatile photopolymerizable citrate-based biomaterial platform that overcomes brittleness and enables broad mechanical tunability, providing a robust foundation for customized biomedical applications ranging from load-bearing to soft tissue engineering.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 23","pages":" 7265-7279"},"PeriodicalIF":6.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/tb/d6tb00602g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}