Journal of Materials Chemistry B最新文献_第5页

Mechanistic study of tumor fluorescence response signals based on a near-infrared viscosity-sensitive probe†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-19 DOI: 10.1039/D4TB02067G

Tianyang Han, Lihao Lin, Huizhong Jiang, Li Fan and Yuewei Zhang

{"title":"Mechanistic study of tumor fluorescence response signals based on a near-infrared viscosity-sensitive probe†","authors":"Tianyang Han, Lihao Lin, Huizhong Jiang, Li Fan and Yuewei Zhang","doi":"10.1039/D4TB02067G","DOIUrl":"10.1039/D4TB02067G","url":null,"abstract":"Viscosity is an important physiological parameter closely associated with various cellular processes and diseases. Several fluorescence probes responsive to viscosity have been developed, demonstrating high sensitivity specifically towards tumor tissues. However, the underlying core mechanism of this highly potential responsive signal has been a subject of debate, as highly sensitive probes encounter excessive environmental interferences in complex tumor tissues. Therefore, we have developed a viscosity-responsive fluorescence probe based on the classical TICT mechanism (twisted intramolecular charge transfer) as a research tool. This probe features an ultra-wide emission range of 700–1200 nm in the near-infrared spectrum, strong photostability, and simultaneous targeting of mitochondria and lysosomes. Through in-depth analysis, we have revealed the intrinsic mechanisms underlying its functionality, demonstrating that the major contributor to the fluorescence change of responsive probes during imaging is the inherent state of cells rather than the tumor microenvironment or the cell type. Our findings provide a theoretical foundation for the continued exploration and application of viscosity-responsive probes.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3959-3966"},"PeriodicalIF":6.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive insights into electrochemical nicotine sensing technologies

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-19 DOI: 10.1039/D4TB02753A

Udhaya Ganesh P. K., Prince J. J. Sagayaraj, Arthanareeswari Maruthapillai, Hyoung-il Kim, Karthikeyan Sekar and Sundaram Gunasekaran

{"title":"Comprehensive insights into electrochemical nicotine sensing technologies","authors":"Udhaya Ganesh P. K., Prince J. J. Sagayaraj, Arthanareeswari Maruthapillai, Hyoung-il Kim, Karthikeyan Sekar and Sundaram Gunasekaran","doi":"10.1039/D4TB02753A","DOIUrl":"10.1039/D4TB02753A","url":null,"abstract":"Nicotine is a significant alkaloid that is abundant in tobacco products. Given the addictive nature of tobacco products and the health risks associated with their consumption, accurate real-time monitoring of nicotine levels is necessary. Electrochemical sensors are low-cost and noninvasive devices for detecting various target molecules, even at trace levels, with advantages such as high sensitivity, portability, and fast response time. Nevertheless, reliable electrochemical detection of nicotine is particularly difficult because of the active interferents present in complex sample matrices. Recent advances in electrochemical sensing have focused on the development of chemically modified electrodes that mimic the oxidase activity of cytochrome P450, thereby improving the selectivity and sensitivity of nicotine detection. This paper discusses several innovative materials and strategies for the practical detection and quantification of nicotine in complex real-world samples. This study focuses on evaluating the factors influencing the sensing performance of the various electrode materials and electrochemical techniques used. The comprehensive information presented in this study will inform future research on the practical real-time monitoring of nicotine in tobacco products, emphasizing the simplicity, efficiency, and cost-effectiveness of the sensor design.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3831-3851"},"PeriodicalIF":6.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A carnitine-based BODIPY photosensitizer†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-19 DOI: 10.1039/D4TB02782E

Larissa Maierhofer, Ruth Prieto-Montero, Tamara Cubiella, Aitor Díaz-Andrés, Noelia Morales-Benítez, David Casanova, Virginia Martínez-Martínez, María-Dolores Chiara, Enrique Mann and Jose Luis Chiara

{"title":"A carnitine-based BODIPY photosensitizer†","authors":"Larissa Maierhofer, Ruth Prieto-Montero, Tamara Cubiella, Aitor Díaz-Andrés, Noelia Morales-Benítez, David Casanova, Virginia Martínez-Martínez, María-Dolores Chiara, Enrique Mann and Jose Luis Chiara","doi":"10.1039/D4TB02782E","DOIUrl":"10.1039/D4TB02782E","url":null,"abstract":"Organelle-selective photodynamic therapy (PDT) has emerged as a promising approach to enhance the precision and efficacy of cancer treatment by targeting key cellular structures. In this study, we report the design of a novel carnitine-based BODIPY photosensitizer, probe 1, which retains mitochondrial selectivity while acting as both a fluorescent probe and a potent photosensitizer. Building on our previously developed mitochondria-targeting probe (R)-BCT-2, which is transported into the mitochondrial matrix by the inner membrane protein carnitine–acylcarnitine translocase (CAC), probe 1 incorporates two bromine atoms that enhance intersystem crossing, leading to a singlet oxygen quantum yield of ∼80%, while retaining sufficient fluorescence for effective cell staining in fluorescence microscopy. Theoretical calculations indicate that the carnitine moiety distorts chromophore planarity, reducing oscillator strength but enhancing spin–orbit coupling, which, together with the extended triplet lifetime, contributes to increased phototoxicity. Probe 1 co-localizes in both mitochondria and, to a lesser extent, in lysosomes, and this dual targeting may synergistically enhance phototoxic activity by amplifying cellular stress responses. Importantly, probe 1 demonstrated high phototoxicity upon green light irradiation, with IC50 values of 52 nm under normoxia and 117 nm under hypoxia, while remaining non-cytotoxic in the dark. These results suggest that probe 1 is a promising candidate for organelle-targeted PDT, particularly in hypoxic tumor environments where its dual organelle targeting could enhance therapeutic efficacy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 14","pages":" 4330-4340"},"PeriodicalIF":6.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02782e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of concern: Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters 表达关切：使用还原氧化石墨烯-聚乙烯亚胺柔性纳米加热器高效捕获和光热消融浮游细菌和生物膜。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-18 DOI: 10.1039/D5TB90031J

Milica Budimir, Roxana Jijie, Ran Ye, Alexandre Barras, Sorin Melinte, Alejandro Silhanek, Zoran Markovic, Sabine Szunerits and Rabah Boukherroub

引用次数: 0

Accelerated dermal wound healing in diabetic mice by a H2O2-generating catechol-functionalized gelatin microgel†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-18 DOI: 10.1039/D4TB01722F

Pegah Kord Forooshani, Fatemeh Razaviamri, Ariana Smies, Lea M. Morath, Rattapol Pinnaratip, Md Saleh Akram Bhuiyan, Rupak Rajachar, Jeremy Goldman and Bruce P. Lee

{"title":"Accelerated dermal wound healing in diabetic mice by a H2O2-generating catechol-functionalized gelatin microgel†","authors":"Pegah Kord Forooshani, Fatemeh Razaviamri, Ariana Smies, Lea M. Morath, Rattapol Pinnaratip, Md Saleh Akram Bhuiyan, Rupak Rajachar, Jeremy Goldman and Bruce P. Lee","doi":"10.1039/D4TB01722F","DOIUrl":"10.1039/D4TB01722F","url":null,"abstract":"Physically crosslinked gelatin microgels were functionalized with a bioadhesive molecule, catechol, to study the effect of in situ generated H2O2 on full-thickness wound repair in diabetic mice. Due to the physically crosslinked nature of the microgels, they transition into a hydrogel film upon hydration. The formation of a hydrogel film was confirmed by the changes in their morphology and viscoelastic properties. Additionally, these microgels released up to 86 μM of H2O2 as a result of catechol autoxidation. The generated H2O2 completely eradicated Staphylococcus epidermidis with an initial concentration of 103 CFU mL−1. These microgels were not cytotoxic and promoted VEGF upregulation in immortalized human keratinocytes (HaCaT) in vitro. When the microgels were applied to a full-thickness dermal wound in diabetic mice, dermal wound closure was accelerated over 14 days, achieving a wound closure of 90% based on the wound area. Microgel-treated wounds also resulted in complete re-epithelialization and regeneration of new dermal tissues with morphology and structure resembling those of native tissues. These results indicate that the release of micromolar concentrations of H2O2 can accelerate wound healing in a healing-impaired animal.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3967-3979"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tunable stimuli-responsive module based on an α-hydroxymethyl-α,β-unsaturated carbonyl scaffold†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-18 DOI: 10.1039/D4TB02818J

Ruipeng Shen, Baoxin Zhang, Lanning Zhao, Bingbing Chang, Fang Zhang, Yating Chen and Jianguo Fang

{"title":"A tunable stimuli-responsive module based on an α-hydroxymethyl-α,β-unsaturated carbonyl scaffold†","authors":"Ruipeng Shen, Baoxin Zhang, Lanning Zhao, Bingbing Chang, Fang Zhang, Yating Chen and Jianguo Fang","doi":"10.1039/D4TB02818J","DOIUrl":"10.1039/D4TB02818J","url":null,"abstract":"The α-hydroxymethyl-α,β-unsaturated carbonyl (HMUC) scaffold represents a valuable framework for constructing nucleophile-responsive materials. However, nucleophiles are largely limited to thiols and amines. Given the ubiquity of thiols and amines in biological systems, this limitation hinders the creation of materials that can be selectively activated by exogenous stimuli. By tuning the electron density of the double bond and assessing its reactivity with various nucleophiles, we present here the discovery of the N-ethyl-2-(hydroxymethyl)acrylamide (NEHMAA) scaffold as a versatile building block for fabricating exogenous stimuli-responsive materials. The selenol species 4-cyanobenzylselenol (from its precursor bis(4-cyanobenzyl)diselenide, Se4) effectively activates NEHMAA-decorated “caged” molecules. Furthermore, the NEHMAA unit was employed to prepare prodrugs, and Se4-dependent cytotoxicity of these prodrugs was observed in cancer cells. The orthogonal reactivity between the NEHMAA unit and Se4 enriches the existing repertoire for constructing exogenous stimuli-responsive smart materials.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 12","pages":" 3980-3989"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic NIR-II aggregation-induced emission nanoparticles for targeted photothermal therapy of ovarian cancer†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-18 DOI: 10.1039/D4TB02855D

Ting Jiang, Chunlei Guo, Zhiwei Zhang, Chao Li, Chunbai Xiang, Jingjing Xiang, Xing Yang, Yu Liu, Lintao Cai, Ping Gong, Yan Hu and Changzhong Li

{"title":"Biomimetic NIR-II aggregation-induced emission nanoparticles for targeted photothermal therapy of ovarian cancer†","authors":"Ting Jiang, Chunlei Guo, Zhiwei Zhang, Chao Li, Chunbai Xiang, Jingjing Xiang, Xing Yang, Yu Liu, Lintao Cai, Ping Gong, Yan Hu and Changzhong Li","doi":"10.1039/D4TB02855D","DOIUrl":"10.1039/D4TB02855D","url":null,"abstract":"Photothermal therapy (PTT) is a cutting-edge technique that harnesses light energy and converts it into heat for precise tumor ablation. By employing photothermal agents to selectively generate heat and target cancer cells, PTT has emerged as a promising cancer treatment strategy. Notably, therapies conducted in the second near-infrared (NIR-II) window exhibit superior therapeutic outcomes, owing to deeper tissue penetration and reduced light scattering. In this study, we developed biomimetic NIR-II aggregation-induced emission (AIE) nanoparticles (2TB-NPs@TM) for high-efficiency NIR-II imaging and targeted phototherapy of ovarian cancer. The core nanoparticle aggregates (2TB-NPs) display strong NIR-II fluorescence and high photothermal conversion efficiency, while the outer tumor cell membrane coating facilitates active targeting and precise recognition of tumor tissues. This design imparts excellent biocompatibility and enhances drug delivery efficiency, leading to potent synergistic therapeutic effects. Our findings open new avenues for advancing targeted, high-performance phototherapy diagnostics in cancer treatment.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 13","pages":" 4094-4102"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A supramolecular tranexamic acid with enhanced permeability and bioactivity†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-18 DOI: 10.1039/D4TB02781G

Zhenyuan Wang, Tie Dong, Jin Yang, Yiyu Wang, Mi Wang and Jiaheng Zhang

{"title":"A supramolecular tranexamic acid with enhanced permeability and bioactivity†","authors":"Zhenyuan Wang, Tie Dong, Jin Yang, Yiyu Wang, Mi Wang and Jiaheng Zhang","doi":"10.1039/D4TB02781G","DOIUrl":"10.1039/D4TB02781G","url":null,"abstract":"Due to its rich bioactivities, tranexamic acid (TA) has garnered significant attention in the biomedical and cosmetic fields. However, TA's hydrophilic nature impedes its penetration through the skin's stratum corneum. This limitation is addressed in the current study by designing a supramolecular TA, i.e., GATA, based on the non-covalent interactions between TA and glycolic acid (GA). The structure and formation mechanism of GATA are explored using multidimensional characterization techniques, including single crystal analysis and computer-aided simulations. In vitro, the supramolecular interactions within GATA facilitate deeper TA penetration into the skin, achieving >2.5 times improved transdermal permeability than pure TA. Notably, GATA does not damage the skin barrier, with the associated irritation and cytotoxicity significantly lower than that caused by GA. Moreover, compared with TA, GATA has comparable or superior thermal stability, water solubility, anti-glycation, antioxidant, and anti-inflammatory properties. GATA also exhibits excellent skin whitening efficacy. Hence, GATA is a promising alternative to TA, with enhanced permeability, bioactivity, and biosafety, as well as considerable application prospects in transdermal delivery.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3553-3563"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a chitosan/polyvinyl alcohol hydrogel loaded with graphene oxide and nano TiO2 for bone defect reconstruction in a dog model

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-17 DOI: 10.1039/D4TB02553A

Ahmed Ibrahim, Khaled M. A. Hassanein, Shereen Ibrahim Zakaria Hussein, Mohammed M. A. Semieka and Abdelnaby M. Elshahawy

{"title":"Evaluation of a chitosan/polyvinyl alcohol hydrogel loaded with graphene oxide and nano TiO2 for bone defect reconstruction in a dog model","authors":"Ahmed Ibrahim, Khaled M. A. Hassanein, Shereen Ibrahim Zakaria Hussein, Mohammed M. A. Semieka and Abdelnaby M. Elshahawy","doi":"10.1039/D4TB02553A","DOIUrl":"10.1039/D4TB02553A","url":null,"abstract":"This study evaluated the application of chitosan/polyvinyl alcohol/graphene oxide/nano titanium oxide (CS/PVA/GO/nano TiO2) hydrogels for bone defect reconstruction in dogs. Dogs were subjected to mid-diaphyseal circular bone defects (0.8 cm2) in the radius bones. Bone defects were implanted with the hydrogel in the treated group (n = 9), while the control group were subjected to spontaneous healing (n = 9). Dogs were subjected to clinical, radiographic, and scanning electron microscopy (SEM) evaluations at 15-, 30-, and 45-days post-surgery. Dogs in the treated group recorded no lameness by the end of the third week post-surgery, while dogs in the untreated group still exhibited lameness of grade 1. There was a significant decrease (p < 0.05) in the cortical defect (mm) of the treated group (5.46 ± 0.17 and 1.45 ± 0.13) compared with the control group (7.57 ± 0.05 and 7.59 ± 0.06) at 30- and 45-days post-surgery, respectively. The depth of the bone defects (mm) decreased significantly (p < 0.05) in the treated group (2.26 ± 0.12 and 0.008 ± 0.002) compared with the untreated group (4.05 ± 0.05 and 2.16 ± 0.07) at 30- and 45-days post-surgery, respectively. Throughout the period of study, there was a significant increase (p < 0.05) in the radiographic density of the bone defects (px) in the treated group (474 ± 17.88) compared with that in the control group (619.6 ± 6.85). SEM results revealed complete closure of the bone defects in the treated group. Thus, implantation of bone defects with the CS/PVA/GO/nano TiO2 hydrogel represents a promising bone graft substitute for accelerating bone healing.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3581-3592"},"PeriodicalIF":6.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermally adaptive iohexol-loaded microcages for local computerized tomography†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-02-17 DOI: 10.1039/D4TB02531H

Jie Qiao, Jiao Dong, Jianhao Wang, Shuxuan Liu, Yao Wang, Xian Li, Hao Li and Guofu Zhou

{"title":"Thermally adaptive iohexol-loaded microcages for local computerized tomography†","authors":"Jie Qiao, Jiao Dong, Jianhao Wang, Shuxuan Liu, Yao Wang, Xian Li, Hao Li and Guofu Zhou","doi":"10.1039/D4TB02531H","DOIUrl":"10.1039/D4TB02531H","url":null,"abstract":"As one of the most used non-invasive imaging modalities, X-ray computed tomography (CT) has many outstanding advantages, but its wide application is still limited owing to various defects of its contrast agents, such as their short in vivo retention time, non-specific distribution, and potential nephrotoxicity. Herein, a non-ionic poly(acrylamide-co-acrylonitrile) copolymer with an upper critical solution temperature (UCST) was utilized to construct novel thermo-responsive microcages (MCs) with a hydrodynamic size of 5–10 μm, which is slightly less than the diameter of a blood vessel, for targeted CT imaging. These MCs exhibited excellent thermo-responsive capability, featuring the appropriate UCST value between 35–40 °C. A reversible UCST-type phase transition endowed these MCs with dramatic expansion above UCST for local embolization in hyperthermia site, and good recovery was observed below UCST for elimination from microvessels after treatments. As a micro-sized carrier, they also exhibited high loading (14.3%) and encapsulation efficiency of iohexol (16.6%) and heat-enhanced release (29.54% in 48 hours), favoring CT imaging with weak signal attenuation. Given their good biocompatibility and biosecurity, these smart MCs are anticipated to develop into facile, effective, safe, and targeted CT contrast agents.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 11","pages":" 3669-3676"},"PeriodicalIF":6.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0