Journal of Materials Chemistry B最新文献_第4页

MnO2-mineralized milk exosomes as a novel nanoplatform for glutathione detection† 二氧化锰矿化牛奶外泌体作为谷胱甘肽检测的新型纳米平台。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-01 DOI: 10.1039/D4TB01662A

Xudong Wang, Xue Wu, Jiuheng Shen, Xian Zhao, Peifen Gao, Wantong Zhou and Wenlin An

{"title":"MnO2-mineralized milk exosomes as a novel nanoplatform for glutathione detection†","authors":"Xudong Wang, Xue Wu, Jiuheng Shen, Xian Zhao, Peifen Gao, Wantong Zhou and Wenlin An","doi":"10.1039/D4TB01662A","DOIUrl":"10.1039/D4TB01662A","url":null,"abstract":"Exosomes have garnered significant attention in the realms of disease diagnosis and therapeutics, owing to their remarkable biocompatibility. While engineered exosomes have the potential to augment delivery efficiency, targeting specificity, and circulation longevity, the intricacies of sample preparation have often hindered their broader application. In this pioneering study, we introduce a novel nanoplatform by leveraging surface manganese dioxide (MnO2) mineralization of milk exosomes. This innovative technique not only amplifies the inherent properties of exosomes but also endows them with additional functionalities, transforming them into a multifaceted tool for disease detection and therapeutic intervention. To expand the application of MnO2@milk exosomes, milk exosomes were stained with lipophilic molecules (curcumin) to prepare MnO2@mEVs-curcumin (MEC). The prepared nanocomposite was employed to detect GSH in cancer cells. By integrating exosome engineering with surface mineralization, we have paved the way for the creation of advanced biomaterials.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 1","pages":" 249-255"},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A surface modified laser-induced graphene based flexible biosensor for multiplexed sweat analysis† 基于表面修饰激光诱导石墨烯的柔性生物传感器，用于多路复用汗液分析。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-01 DOI: 10.1039/D4TB01936A

Sudipta Choudhury, Saad Zafar, Deepak Deepak, Abhishek Panghal, Bimlesh Lochab and Susanta Sinha Roy

{"title":"A surface modified laser-induced graphene based flexible biosensor for multiplexed sweat analysis†","authors":"Sudipta Choudhury, Saad Zafar, Deepak Deepak, Abhishek Panghal, Bimlesh Lochab and Susanta Sinha Roy","doi":"10.1039/D4TB01936A","DOIUrl":"10.1039/D4TB01936A","url":null,"abstract":"The growing popularity of electrochemical sensors featuring non-invasive biosensing technologies has generated significant enthusiasm for continuous monitoring of bodily fluid biomarkers, potentially aiding in the early detection of health issues in individuals. However, detection of multiple biomarkers in complex biofluids often necessitates a high-density array which creates a challenge in achieving cost-effective fabrication methods. To overcome this constraint, this work reports the fabrication of an electrochemical sensor utilizing a NiO–Ti3C2Tx MXene-modified flexible laser-induced graphene (LIG) electrode for the separate and concurrent analysis of ascorbic acid (AA), dopamine (DA), and uric acid (UA) in human sweat and also addresses the deficiencies in the existing state of the art by offering a cost-efficient and high-performance sensor that mitigates the degrading constraints of conventional LIG electrodes. Cyclic voltammetry and differential pulse voltammetry measurements reveals that the electrochemical properties of the modified electrode, attain a low detection limit and great sensitivity for the target biomarkers. The NiO–Ti3C2Tx/LIG sensor demonstrated enhanced electrocatalytic activity for the oxidation of ascorbic acid, dopamine, and uric acid, and proved useful for analysing these biomarkers in synthetic sweat samples. Under the optimized conditions, the LOD values were estimated to be 16, 1.97 and 0.78 μM for AA, DA and UA, respectively. The developed high-efficiency sensor holds significant promise for applications in flexible and wearable electronics for health monitoring.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 1","pages":" 274-287"},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionalities of pH-responsive DNA nanostructures in tumor-targeted strategies pH 响应 DNA 纳米结构在肿瘤靶向策略中的功能。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-01 DOI: 10.1039/D4TB01883D

Liyue Wen and Min Wang

引用次数: 0

Advancing cancer therapy with a heptamethine carbocyanine dye-conjugated radionuclide drug† 利用七甲烷羰花青染料共轭放射性核素药物推进癌症治疗。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-11-01 DOI: 10.1039/D4TB01798F

Mingxing Huang, Weichen Wang, Yingwei Wang, Rang Wang, Lili Pan, Xin Li, Bo Li, Jingsong Zhang, Ruoxiang Wang, Yi Zhang and Rong Tian

{"title":"Advancing cancer therapy with a heptamethine carbocyanine dye-conjugated radionuclide drug†","authors":"Mingxing Huang, Weichen Wang, Yingwei Wang, Rang Wang, Lili Pan, Xin Li, Bo Li, Jingsong Zhang, Ruoxiang Wang, Yi Zhang and Rong Tian","doi":"10.1039/D4TB01798F","DOIUrl":"10.1039/D4TB01798F","url":null,"abstract":"Malignant tumors pose substantial treatment challenges due to their heterogeneity, metastatic potential, and therapeutic resistance, underscoring the urgent need for more effective treatment options. In this study, a novel radionuclide drug conjugate (RDC) was developed and characterized employing a tumor-targeting heptamethine carbocyanine dye (DZ) for its high specificity and favourable safety profile. The RDC, DOTA-DZ-HX, was synthesized by conjugating DZ with dodecane tetraacetic acid (DOTA) through a dipeptide linker. The anti-tumor efficacy and biodistribution of [177Lu]Lu-DOTA-DZ-HX were assessed in H1975 and HeLa xenograft models. [177Lu]Lu-DOTA-DZ-HX showed high stability, specific tumor accumulation, and substantial radioactivity retention at the tumor site for seven days. Biodistribution analysis revealed that the drug exhibited prolonged blood circulation with gradual clearance. Additionally, [177Lu]Lu-DOTA-DZ-HX could effectively and selectively inhibit tumor growth, as evidenced by a significant reduction in tumor volume. These findings suggest that heptamethine carbocyanine dye-directed radionuclide targeting could provide an effective treatment for cancer and potentially other malignancies, representing a significant advancement in cancer therapy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 1","pages":" 256-263"},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence sensing techniques for quality evaluation of traditional Chinese medicines: a review 用于中药质量评价的荧光传感技术：综述。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-10-31 DOI: 10.1039/D4TB01886A

Yanyu Xiao, Hui Wang, Chenxia Gao, Xinyi Ye, Yuting Lai, Meiling Chen and Xiaoliang Ren

{"title":"Fluorescence sensing techniques for quality evaluation of traditional Chinese medicines: a review","authors":"Yanyu Xiao, Hui Wang, Chenxia Gao, Xinyi Ye, Yuting Lai, Meiling Chen and Xiaoliang Ren","doi":"10.1039/D4TB01886A","DOIUrl":"10.1039/D4TB01886A","url":null,"abstract":"Traditional Chinese medicines (TCMs) are highly valued and widely used worldwide. However, their complex compositions and various preparation processes have brought considerable challenges to the quality evaluation of Chinese medicines. The traditional methods for TCM quality evaluation suffer from the problems of cumbersome sample preparation, a long detection time, low sensitivity, etc. A more efficient and accurate evaluation method is urgently needed to ensure the stability and reliability of the quality of TCMs. As an emerging analytical technology, a fluorescent probe has the advantages of high sensitivity, high selectivity, easy operation, etc. It is capable of generating a specific fluorescent signal response to specific components in traditional Chinese medicines, realizing rapid and accurate detection of target components, which effectively solves the many difficulties of traditional methods. The purpose of this paper is to discuss the application of fluorescent probes in the quality evaluation of traditional Chinese medicines and the challenges they face. By introducing the principles, advantages and specific application cases of fluorescent probe technology in the quality evaluation of traditional Chinese medicines, we hope to provide new and efficient analytical ideas for the quality evaluation of traditional Chinese medicines.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 48","pages":" 12412-12436"},"PeriodicalIF":6.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrafibrillar calcium carbonate mineralization of electrospinning polyvinyl alcohol/collagen films with improved mechanical and bioactive properties† 电纺丝聚乙烯醇/胶原蛋白薄膜的纤维内碳酸钙矿化，具有更好的机械和生物活性特性。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-10-31 DOI: 10.1039/D4TB01472C

Yin Liu, Xin Gao, Yuqi Li, Anqi Gao, Zhuozhi Zheng, Jingjiang Wei, Hongye Yang, Hang Ping, Hao Xie, Hao Wang, Weimin Wang and Zhengyi Fu

{"title":"Intrafibrillar calcium carbonate mineralization of electrospinning polyvinyl alcohol/collagen films with improved mechanical and bioactive properties†","authors":"Yin Liu, Xin Gao, Yuqi Li, Anqi Gao, Zhuozhi Zheng, Jingjiang Wei, Hongye Yang, Hang Ping, Hao Xie, Hao Wang, Weimin Wang and Zhengyi Fu","doi":"10.1039/D4TB01472C","DOIUrl":"10.1039/D4TB01472C","url":null,"abstract":"Collagen films play an essential role in guided bone-regeneration (GBR) techniques, which create space, promote cell adhesion, and induce osteogenic differentiation. It is therefore crucial to design appropriate GBR films to facilitate bone regeneration. However, current electrospun collagen scaffolds used as bioactive materials have limited clinical applications due to their poor mechanical properties. In this study, polyvinyl alcohol (PVA)/collagen (Col) films were electrospun by mixing PVA and type I collagen solution. For the first time, the intrafibrillar mineralization of aragonite nanocrystals within the PVA/Col fibrils was achieved, resulting in the formation of a hierarchical, bioactive film. The PVA/Col–CaCO3 film exhibited good mechanical properties, with hardness and Young's modulus values of 211.6 ± 0.1 MPa and 5.6 ± 1.7 GPa, respectively. Furthermore, bone marrow mesenchymal stem cells (BMSCs) inoculated onto the PVA/Col–CaCO3 film demonstrated robust adhesion and proliferation. The mineralized fibrils effectively stimulated the growth of BMSCs while suppressing cell apoptosis. Besides, the PVA/Col–CaCO3 film significantly induced the osteogenic differentiation of BMSCs, revealing its potential biomedical applications in hard tissue engineering.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 1","pages":" 312-325"},"PeriodicalIF":6.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term leaching kinetics and solution chemistry of aqueous BaTiO3 powder suspensions: a numerical model supported experiment 水性 BaTiO3 粉末悬浮液的长期浸出动力学和溶液化学性质：支持实验的数值模型。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-10-31 DOI: 10.1039/D4TB01708K

Marcus Bentzen, Vojtěch Lindauer, Pavel Mokrý, Ragnhild Elizabeth Aune and Julia Glaum

引用次数: 0

Recent advances in two-dimensional materials for drug delivery 用于给药的二维材料的最新进展。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-10-31 DOI: 10.1039/D4TB01787K

Ranran Zhang, Zichao Yan, Ming Gao, Bingxin Zheng, Bin Yue and Meng Qiu

{"title":"Recent advances in two-dimensional materials for drug delivery","authors":"Ranran Zhang, Zichao Yan, Ming Gao, Bingxin Zheng, Bin Yue and Meng Qiu","doi":"10.1039/D4TB01787K","DOIUrl":"10.1039/D4TB01787K","url":null,"abstract":"Two-dimensional (2D) materials exhibit significant potential in biomedical applications, particularly as drug carriers. Thus, 2D materials, including graphene, black phosphorus, transition metal dichalcogenides, transition metal carbides/nitrides, and hexagonal boron nitride, have been extensively studied. Their large specific surface area, abundant surface active sites, and excellent biocompatibility and biodegradability make them ideal platforms for drug loading and delivery. By optimizing the physicochemical properties and methods for the surface modification of 2D materials, improved drug release mechanisms and enhanced combination therapy effects can be achieved, providing a reliable foundation for efficient cancer treatment. This review provides a comprehensive analysis of the recent advances in the utilization of 2D materials for drug delivery. It systematically categorizes and summarizes the preparation methodologies, surface modification strategies, application domains, primary advantages and potential drawbacks of various 2D materials in the biomedical field. Furthermore, it provides an extensive overview of current challenges in this field and outlines potential future research directions for 2D materials in drug delivery based on existing issues.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 48","pages":" 12437-12469"},"PeriodicalIF":6.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of enzymatically crosslinked natural deep eutectogels: versatile gels for enhanced drug delivery† 开发酶交联天然深层共晶凝胶：增强药物输送的多功能凝胶。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-10-30 DOI: 10.1039/D4TB01672F

Liane Meneses, Dimitra Antonia Bagaki, Ana Roda, Alexandre Paiva and Ana Rita C. Duarte

{"title":"Development of enzymatically crosslinked natural deep eutectogels: versatile gels for enhanced drug delivery†","authors":"Liane Meneses, Dimitra Antonia Bagaki, Ana Roda, Alexandre Paiva and Ana Rita C. Duarte","doi":"10.1039/D4TB01672F","DOIUrl":"10.1039/D4TB01672F","url":null,"abstract":"Injectable hydrogels have been extensively studied due to their minimally invasive properties, ease of application, and void-filling properties. In this work, we tested the possibility to prepare a new type of gels, so called eutectogels, where water is replaced by a natural deep eutectic system (NADES), conferring it longer stability. Eutectogels based on betaine : glycerol 1 : 2, were prepared by enzymatic mediated crosslinking, using horseradish peroxidase (HRP) as catalyst and gelatine–phenol conjugated polymer. In comparison to hydrogels, that required higher enzyme concentration (15 U mL−1) to have gelation time under 2 minutes, the eutectogels were obtained using 10 and 5 U mL−1 of HRP, with gelation times of 30 and 50 seconds, respectively. Finally, ketoprofen was loaded into the polymeric matrix, and release studies were conducted. The presence of NADES was essential for the formulation of the drug loaded gel, which was able to release up to 70% of the drug within 10 days, therefore, it was possible to conclude that these eutectogels work as matrix for the controlled delivery of ketoprofen in aqueous medium. The in vitro biological evaluation of the individual components of the eutectogel support no cytotoxic effect, an early indication of potential biocompatibility.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 48","pages":" 12567-12576"},"PeriodicalIF":6.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances of versatile fluorophores for multifunctional biomedical imaging in the NIR-II region 用于近红外-II 区多功能生物医学成像的多功能荧光团的最新进展。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-10-30 DOI: 10.1039/D4TB01957A

Kaiming Ma, Qunying Jiang, Yang Yang and Fan Zhang

引用次数: 0