Journal of Materials Chemistry B最新文献

{"title":"Surface Bi-vacancy and corona polarization engineered nanosheets with sonopiezocatalytic antibacterial activity for wound healing","authors":"Mingbo Wu, Dong Li, Yao Liu, Xiaomiao Ruan, Jingwen Yang, Zegang Li, Siyi Chen, Xin Yang and Wenwu Ling","doi":"10.1039/D4TB02489C","DOIUrl":"10.1039/D4TB02489C","url":null,"abstract":"<p >Piezocatalytic therapy is an emerging therapeutic strategy for eradicating drug-resistant bacteria, but suffers from insufficient piezoelectricity and catalytic active site availability. Herein, Bi-vacancies (BiV) and corona polarization were introduced to BiOBr nanosheets to create a BiOBr-BiVP nanoplatform for piezocatalytic antibacterial therapy. This meticulously tailored strategy strengthens the built-in electric field of nanosheets, enhancing piezoelectric potential and charge density and boosting charge separation and migration efficiency. Meanwhile, BiV adeptly adjust the band structure and increase reaction sites. Ultrasonication of nanosheets continuously enables the generation of reactive oxygen species (ROS) and CO, facilitating almost 100% broad-spectrum antibacterial efficacy. BiOBr-BiVP nanosheets demonstrate full bacterial eradication and accelerate wound healing through simultaneous regulation of inflammatory factors, facilitation of collagen deposition, and promotion of angiogenesis. Overall, this ultrasonic-triggered piezocatalytic nanoplatform combines BiV and the corona polarization strategy, providing a robust strategy for amplifying piezocatalytic mediated ROS/CO generation for drug-resistant bacterial eradication.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 7","pages":" 2533-2548"},"PeriodicalIF":6.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetylation of alginate enables the production of inks that mimic the chemical properties of P. aeruginosa biofilm†","authors":"Stephan Schandl, Goodness Osondu-Chuka, Giuseppe Guagliano, Stjepan Perak, Paola Petrini, Francesco Briatico-Vangosa, Erik Reimhult and Olivier Guillaume","doi":"10.1039/D4TB02675F","DOIUrl":"10.1039/D4TB02675F","url":null,"abstract":"<p >The reason why certain bacteria, <em>e.g.</em>, <em>Pseudomonas aeruginosa</em> (PA), produce acetylated alginate (Alg) in their biofilms remains one of the most intriguing facts in microbiology. Being the main structural component of the secreted biofilm, like the one formed in the lungs of cystic fibrosis (CF) patients, Alg plays a crucial role in protecting the bacteria from environmental stress and potential threats. Nonetheless, to investigate the PA biofilm environment and its lack of susceptibility to antibiotic treatment, the currently developed <em>in vitro</em> biofilm models use native seaweed Alg, which is a non-acetylated Alg. The role of the acetyl side group on the backbone of bacterial Alg has never been elucidated, and the transposition of experimental results obtained from such systems to clinical conditions (<em>e.g.</em>, to treat CF-infection) may be hazardous. We systematically investigated the influence of acetylation on the physico-chemical and mechanical properties of Alg in solution and Ca<small>²⁺</small>-crosslinked hydrogels. Furthermore, we assessed how the acetylation influenced the interaction of Alg with tobramycin, a common aminoglycoside antibiotic for PA. Our study revealed that the degree of acetylation directly impacts the viscosity and Young's Modulus of Alg in a pH-dependent manner. Acetylation increased the mesh size in biofilm-like Alg hydrogels, directly influencing antibiotic penetration. Our results provide essential insights to create more clinically relevant <em>in vitro</em> infection models to test the efficacy of new drugs or to better understand the 3D microenvironment of PA biofilms.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 8","pages":" 2796-2809"},"PeriodicalIF":6.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Preventing biofilm formation and eradicating pathogenic bacteria by Zn doped histidine derived carbon quantum dots","authors":"Vijay Bhooshan Kumar, Maoz Lahav and Ehud Gazit","doi":"10.1039/D5TB90012C","DOIUrl":"10.1039/D5TB90012C","url":null,"abstract":"<p >Correction for ‘Preventing biofilm formation and eradicating pathogenic bacteria by Zn doped histidine derived carbon quantum dots’ by Vijay Bhooshan Kumar <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2024, <strong>12</strong>, 2855–2868, https://doi.org/10.1039/D3TB02488A.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 6","pages":" 2210-2210"},"PeriodicalIF":6.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90012c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-driven biodegradable nanomotors for enhanced cellular uptake†","authors":"Jianhong Wang, Andreas Polyviou, Jari F. Scheerstra, Shoupeng Cao, Alexander D. Fusi, Jingxin Shao and Jan C. M. van Hest","doi":"10.1039/D4TB02633K","DOIUrl":"10.1039/D4TB02633K","url":null,"abstract":"<p >Hybrid nano-sized motors with navigation and self-actuation capabilities have emerged as promising nanocarriers for a wide range of delivery, sensing, and diagnostic applications due to their unique ability to achieve controllable locomotion within a complex biological environment such as tissue. However, most current nanomotors typically operate using a single driving mode, whereas propulsion induced by both external and local stimuli could be more beneficial to achieve efficient motility in a biomedical setting. In this work, we present a hybrid nanomotor by functionalizing biodegradable stomatocytes with platinum nanoparticles (Pt NPs). These Pt NPs enable two distinct propulsion mechanisms. First, near-infrared (NIR) laser irradiation causes plasmonic heating, which, due to the asymmetric shape of the stomatocytes, creates a temperature gradient around the nanomotors. Second, the catalytic properties of the Pt NPs allow them to convert hydrogen peroxide into water and oxygen, generating a chemical gradient that serves as an additional driving force. Hydrogen peroxide is thereby locally produced from endogenous glucose by a co-encapsulated enzyme, glucose oxidase. The motile features are employed to achieve enhanced accumulation within tumor cells. This nanomotor design offers a versatile approach for developing dual stimuli-responsive nanomotors that operate more effectively in complex environments.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 8","pages":" 2820-2825"},"PeriodicalIF":6.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02633k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of adenosine blockade and ferroptosis for photo-immunotherapy of triple negative breast cancer with aptamer-modified copper sulfide†","authors":"Xingyu Zhang, Chengyu Shi, Qiao Liu, Yuting Zhong, Lipeng Zhu and Yuetao Zhao","doi":"10.1039/D4TB02125H","DOIUrl":"10.1039/D4TB02125H","url":null,"abstract":"<p >Combination of immunotherapy and photothermal therapy (PTT) provides a promising therapeutic performance for tumors. However, it still faces negative feedback from suppressive factors such as adenosine. Herein, we developed a new nanodrug that can combine adenosine blockade and ferroptosis to promote the photoimmunotherapy of triple negative breast cancer (TNBC). The nanodrug, named CuS-PEG@Apt, was constructed <em>via</em> the modification of copper sulfide (CuS) nanoparticles with adenosine aptamer and PEG. CuS-PEG@Apt could be effectively enriched in the tumor site and locally generate a strong photothermal effect, directly ablating tumors and inducing immunogenic death (ICD). On the other hand, the aptamers could block the adenosine pathway to inhibit the immune suppression by adenosine, which further promoted the anti-tumor immunity. Moreover, the CuS nanoparticles could consume GSH and inhibit GPX4 to cause the ferroptosis of tumor cells. Collectively, CuS-PEG@Apt achieved potent efficacy of tumor suppression <em>via</em> the combination of PTT, immune activation and ferroptosis, representing an appealing platform for TNBC treatment.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 7","pages":" 2504-2519"},"PeriodicalIF":6.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A versatile two-light mode triggered system for highly localized sequential release of reactive oxygen species and conjugated drugs from mesoporous organosilica particles†","authors":"Hannah Bronner, Katharina Doll-Nikutta, Sören Donath, Nina Ehlert, Yaşar Krysiak, Alexander Heisterkamp, Meike Stiesch, Stefan Kalies and Sebastian Polarz","doi":"10.1039/D4TB02691H","DOIUrl":"10.1039/D4TB02691H","url":null,"abstract":"<p >The increasing prevalence of antimicrobial resistance and adverse effects of systemic treatments calls for urgent reevaluation of current methods that rely on excessive, uncontrolled drug administration. In recent years triggerable systems have emerged as promising alternatives, enabling time-controlled and localized drug release, which are only activated if necessary. Light is an obvious candidate as an external trigger, since it allows for localized activation, is non-invasive and its wavelength and intensity can be tailored to fit the demands of the drug release system. Such localized and triggered systems minimize off-target effects and undesired exposure, making it a promising tool for combating health threats such as antimicrobial resistance. However, the limited tissue penetration of visible light significantly limits the applicability of this concept <em>in vivo</em>. Here, we introduce an innovative triggerable drug release system, based on mono-, bi-, and tri-functionalized mesoporous organosilica particles (MOPs). The limited tissue penetration is addressed by an advanced trigger system featuring two-photon absorption. Two-photon absorption enables utilization of near-infrared (NIR) light as a trigger, which is known to exhibit an enhanced penetration depth. The particles are designed to release reactive oxygen species (ROS) upon NIR irradiation and undergo Förster resonance energy transfer (FRET) to a ROS producing dye. Moreover, by oxidative cleavage, an additional therapeutic agent is released in a cascade reaction, enhancing the system's effectiveness. The ROS release is microscopically demonstrated <em>in situ</em> and, for the first time, release of a fluorescent compound (therapeutic agent) in a cascade reaction is observed in real-time, providing valuable insights into the behavior and performance of our particles. This novel sequential dual-release platform for light-triggered therapeutic delivery has great potential for advanced therapeutic applications in both superficial and deep tissue treatments.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3032-3038"},"PeriodicalIF":6.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02691h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic understanding of pH as a driving force in cancer therapeutics","authors":"Vivek Pandey and Tejasvi Pandey","doi":"10.1039/D4TB02083A","DOIUrl":"10.1039/D4TB02083A","url":null,"abstract":"<p >The development of pH-directed nanoparticles for tumor targeting represents a significant advancement in cancer biology and therapeutic strategies. These innovative materials have the ability to interact with the unique acidic microenvironment of tumors. They enhance drug delivery, increase therapeutic efficacy, and reduce systemic toxicity. The acidic conditions within tumors trigger the release of drugs from pH-responsive nanoparticles, ensuring targeted and controlled delivery directly to cancer cells while minimizing damage to healthy tissues. This review comprehensively explores the design, synthesis, and application of pH-stabilized nanoparticles in cancer therapy. It delves into the mechanisms of pH-responsive behavior, such as the use of pH-sensitive polymers and cleavable linkages that respond to the acidic tumor environment. Current strategies for nanoparticle stabilization, including surface coating, core–shell nanostructures, and hybrid nanoparticles, are discussed in detail, highlighting how these approaches enhance the stability and functionality of the nanoparticles in biological systems. Recent advancements in nanoparticle-based drug delivery systems are examined, showcasing multi-functional nanoparticles that combine therapeutic and diagnostic functions, as well as those designed for combination therapy to overcome drug resistance. This review identifies future directions in the field, such as the need for improved stability and biocompatibility, controlled and predictable drug release, and overcoming regulatory and manufacturing hurdles. Herein, we have highlighted the transformative potential of pH-stabilized nanoparticles in cancer therapy, offering a pathway towards more effective and targeted cancer treatments.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 8","pages":" 2640-2657"},"PeriodicalIF":6.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal–organic frameworks as anchors for giant unilamellar vesicle immobilization†","authors":"Aroosha Faheem, Mason C. Lawrence, Gazi A. Bushra, M.-Vicki Meli and Barry A. Blight","doi":"10.1039/D4TB02055C","DOIUrl":"10.1039/D4TB02055C","url":null,"abstract":"<p >Giant unilamellar vesicles (GUVs) are ideal for studying cellular mechanisms due to their cell-mimicking morphology and size. The formation, stability, and immobilization of these vesicles are crucial for drug delivery and bioimaging studies. Separately, metal–organic frameworks (MOFs) are actively researched owing to their unique and varied properties, yet little is known about the interaction between MOFs and phospholipids. This study investigates the influence of the metal–phosphate interface on the formation, size distribution, and stability of GUVs with different lipid compositions. GUVs were electroformed in the presence of a series of MOFs. The results show Al, Zn, Cu, Fe, Zr, and Ca metal centers of MOFs can coordinate to phospholipids on the surface of GUVs, leading to the formation of functional GUV@MOF constructs, with stablilities over 12 hours. Macroscopically, society has seen biology (people, plants, microbes) interacting with inorganic materials regularly. We now explore how microscopic biological models behave in the presence of inorganic constructs. This research opens new avenues for advanced biomedical applications interacting tailored frameworks with liposomes.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 7","pages":" 2317-2326"},"PeriodicalIF":6.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02055c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy","authors":"Yanqiang Yang, Chen Dong, Xuehua Ma, Yanan Wang, Zhouhua Li, Yuan Xu, Tianxiang Chen, Changyong Gao, Xiaoqun Ye, Aiguo Wu and Xinyi Zhang","doi":"10.1039/D4TB02746A","DOIUrl":"10.1039/D4TB02746A","url":null,"abstract":"<p >Cuproptosis, a newly identified programmed cell death form, is characterized by excessive copper accumulation in cells, resulting in mitochondria damage and toxic protein stress, ultimately causing cell death. Given the considerable therapeutic promise of copper toxicity in cancer treatment, copper-based nanomaterials that induce copper death have attracted interest as a promising approach for tumor therapy. This review comprehensively introduces the mechanisms of cuproptosis and the associated regulatory genes, including both positive and negative regulatory regulators, and systematically summarizes the application of various nanoparticles in inducing cuproptosis, ranging from inorganic copper compounds to delivery systems. These nanoparticles offer significant advantages, such as improving copper absorption, extending the duration of effectiveness, enhancing the precision of copper release, increasing biocompatibility, and serving as enhancers in combination therapy. In conclusion, the authors present a detailed overview and insights into the current research directions of nanoplatforms that facilitate copper-induced cancer treatment, establishing a foundation for the future development of effective nanomedicines that induce cuproptosis and offering new possibilities and treatment strategies for tumor therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 2978-2999"},"PeriodicalIF":6.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the multifaceted roles of metal–organic frameworks in ecosystem regulation","authors":"Wanjing Li, Jing Chen, Jian Guo, Ka Teng Chan, Yini Liang, Meixuan Chen, Jing Wang, Srinivas Gadipelli, Xuedong Zhou and Lei Cheng","doi":"10.1039/D4TB01882F","DOIUrl":"10.1039/D4TB01882F","url":null,"abstract":"<p >Achieving microecological balance is a complex environmental challenge. This is because the equilibrium of microecological systems necessitates both the eradication of harmful microorganisms and preservation of the beneficial ones. Conventional materials predominantly target the elimination of pathogenic microorganisms and often neglect the protection of advantageous microbial species. Metal–organic frameworks (MOFs) with excellent physicochemical properties (such as crystalline particles of various dimensions with highly porous network topology, variable local networking structures, diverse compositions with functional groups, high specific surface areas and pore volumes for surface and porous guest molecular adsorption/adhesion/affinity/binding and separation) have been extensively studied as a type of bactericidal material. However, only recently, studies on using MOFs to protect microorganisms have been reported. This review provides a comprehensive analysis of the mechanisms and applications of various MOFs (such as ZIF-8, ZIF-90, HKUST-1, MOF-5, and MIL-101) in both microbial eradication and protection. Insights into previous studies on MOF development, the material-bacteria interaction mechanisms, and potential clinical and environmental applications are also elucidated. MOFs with different framework structures/topologies (zeolite, sodalite, scaffolding, diamond, one-dimensional, and spherical/cylindrical cavities/pore networks), particle dimensions, polyhedral, cubic, rod and open/uncoordinated metal centers or fully coordinated metal centers, and ligand functional groups are discussed to understand the varying degrees of activation and interaction of microorganisms. This review holds potential in guiding future research on the design, synthesis, utilization, and integration of MOFs for the targeted eradication and protection of microorganisms and generating novel MOFs with selective antimicrobial and protective properties. Moreover, this review delivers a timely update and outlines future prospects for MOFs and their interaction with microorganisms, emphasizing their potential as a promising candidate among the next generation of smart materials in the field of ecosystem regulation.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 7","pages":" 2272-2294"},"PeriodicalIF":6.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}