Journal of Materials Chemistry B最新文献_第4页

Effect of molar mass and alkyl chain length on the surface properties and biocompatibility of poly(alkylene terephthalate)s for potential cardiovascular applications† 摩尔质量和烷基链长度对聚对苯二甲酸亚烷基酯表面性质和生物相容性的影响，用于潜在的心血管应用。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-16 DOI: 10.1039/D3TB01889J

Lenny Van Daele, Babs Van de Voorde, Robin Colenbier, Lobke De Vos, Laurens Parmentier, Louis Van der Meeren, André Skirtach, Ruslan I. Dmitriev, Peter Dubruel and Sandra Van Vlierberghe

{"title":"Effect of molar mass and alkyl chain length on the surface properties and biocompatibility of poly(alkylene terephthalate)s for potential cardiovascular applications†","authors":"Lenny Van Daele, Babs Van de Voorde, Robin Colenbier, Lobke De Vos, Laurens Parmentier, Louis Van der Meeren, André Skirtach, Ruslan I. Dmitriev, Peter Dubruel and Sandra Van Vlierberghe","doi":"10.1039/D3TB01889J","DOIUrl":"10.1039/D3TB01889J","url":null,"abstract":"Cardiovascular diseases are the leading cause of death worldwide. Treatments for occluded arteries include balloon angioplasty with or without stenting and bypass grafting surgery. Poly(ethylene terephthalate) is frequently used as a vascular graft material, but its high stiffness leads to compliance mismatch with the human blood vessels, resulting in altered hemodynamics, thrombus formation and graft failure. Poly(alkylene terephthalate)s (PATs) with longer alkyl chain lengths hold great potential for improving the compliance. In this work, the effect of the polymer molar mass and the alkyl chain length on the surface roughness and wettability of spin-coated PAT films was investigated, as well as the endothelial cell adhesion and proliferation on these samples. We found that surface roughness generally increases with increasing molar mass and alkyl chain length, while no trend for the wettability could be observed. All investigated PATs are non-cytotoxic and support endothelial cell adhesion and growth. For some PATs, the endothelial cells even reorganized into a tubular-like structure, suggesting angiogenic maturation. In conclusion, this research demonstrates the biocompatibility of PATs and their potential to be applied as materials serving cardiovascular applications.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 42","pages":" 10158-10173"},"PeriodicalIF":7.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and anti-tumor effects of mesoporous silica nanoparticles loaded with trifluoperazine 负载三氟拉嗪的介孔二氧化硅纳米颗粒的制备及其抗肿瘤作用。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-14 DOI: 10.1039/D3TB01472J

Yunfeng Ma, Longxia Li, Liufang Mo, Xiaochen Wang, Chenyue Liu, Yijun Wu and Chaoqun Liu

{"title":"Preparation and anti-tumor effects of mesoporous silica nanoparticles loaded with trifluoperazine","authors":"Yunfeng Ma, Longxia Li, Liufang Mo, Xiaochen Wang, Chenyue Liu, Yijun Wu and Chaoqun Liu","doi":"10.1039/D3TB01472J","DOIUrl":"10.1039/D3TB01472J","url":null,"abstract":"We have developed a targeted nano-drug delivery system that effectively harnesses the anti-tumor properties of trifluoperazine (TFP), while concurrently mitigating its side effects on the central nervous system. The manufacturing process entailed the preparation of mesoporous silica nanoparticles (MSN-NH2), followed by the loading of trifluoperazine into the pores of MSN-NH2 and then surface modification with polyethylene glycol (PEG) and anisamide (AA), resulting in the formation of TFP@MSN@PEG-AA (abbreviated as TMPA) nanoparticles. In vitro and in vivo anti-tumor activity and hemolysis experiments showed that TMPA had an excellent safety profile and a good anti-tumor effect. Importantly, the drug content of the TMPA nanoparticle group was found to be significantly lower than that of the TFP group in the mouse brain tissue as determined by High Performance Liquid Chromatography (HPLC) detection. Therefore, the developed drug delivery system achieved the goal of maintaining TFP's anti-tumor action while avoiding its negative effects on the central nervous system.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 43","pages":" 10395-10403"},"PeriodicalIF":7.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etamsylate loaded oxidized Konjac glucomannan-ε-polylysine injectable hydrogels for rapid hemostasis and wound healing Etamsylate负载氧化魔芋葡甘聚糖-ε-聚赖氨酸可注射水凝胶，用于快速止血和伤口愈合。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-13 DOI: 10.1039/D3TB01904G

Shuo Xu, Jun You, Shaorong Yan, Luting Zhu and Xiaochen Wu

引用次数: 0

A multifunctional bio-patch crosslinked with glutaraldehyde for enhanced mechanical performance, anti-coagulation properties, and anti-calcification properties 一种与戊二醛交联的多功能生物贴片，具有增强的机械性能、抗凝血性能和抗钙化性能。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-12 DOI: 10.1039/D3TB01724A

Jiahao Chang, Liyin Yu, Jiao Lei, Xiaoli Liu, Chunxiao Li, Yali Zheng and Hong Chen

{"title":"A multifunctional bio-patch crosslinked with glutaraldehyde for enhanced mechanical performance, anti-coagulation properties, and anti-calcification properties","authors":"Jiahao Chang, Liyin Yu, Jiao Lei, Xiaoli Liu, Chunxiao Li, Yali Zheng and Hong Chen","doi":"10.1039/D3TB01724A","DOIUrl":"10.1039/D3TB01724A","url":null,"abstract":"Bio-patches for the treatment of valvular disease have been evaluated in clinical trials. It has been shown that failure of these devices, occurring within a few years of implantation, may be due to cytotoxicity, immune response, calcification and thrombosis. Some of these effects may be due to the glutaraldehyde crosslinking process used in the preparation of the materials. A number of studies have focused on strategies to control calcification, while others have concentrated on the prevention of micro-thrombus formation. In the present work, we have introduced amino-terminated poly(ethylene glycol) (NH2–PEG–NH2) as an intermolecular bridge, which not only eliminates free aldehyde groups to prevent calcification, but also introduces sites for the attachment of anticoagulant molecules. Furthermore, PEG, itself a hydrophilic polymer with good biocompatibility, may effectively prevent protein adsorption in the early stages of blood contact leading to thrombus formation. After further covalent attachment of heparin, modified bovine pericardium (BP) showed strong anti-calcification (calcium content: 39.3 ± 3.1 μg mg−1) and anti-coagulation properties (partial thromboplastin time: >300 s). The biocompatibility and mechanical properties, important for clinical use, were also improved by modification. The strategy used in this work includes new ideas and technologies for the improvement of valve products used in the clinic.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 43","pages":" 10455-10463"},"PeriodicalIF":7.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54232950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction-responsive polymeric micelles for trans-corneal targeted delivery of microRNA-21-5p and glaucoma-specific gene therapy† 用于经角膜靶向递送微小RNA-21-5p和青光眼特异性基因治疗的还原反应性聚合物胶束。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-12 DOI: 10.1039/D3TB01430D

Binze Han, Rong Zhang, Liping Li, Chunchun Hu, Mengwei Li, Jiamin Liu, Xinghuai Sun, Wenpei Fan, Jinbing Xie and Yuan Lei

{"title":"Reduction-responsive polymeric micelles for trans-corneal targeted delivery of microRNA-21-5p and glaucoma-specific gene therapy†","authors":"Binze Han, Rong Zhang, Liping Li, Chunchun Hu, Mengwei Li, Jiamin Liu, Xinghuai Sun, Wenpei Fan, Jinbing Xie and Yuan Lei","doi":"10.1039/D3TB01430D","DOIUrl":"10.1039/D3TB01430D","url":null,"abstract":"The therapeutic value of microRNA (miRNA) for the treatment of glaucoma has become a focus of attention. However, naked miRNA cannot cross the corneal barrier and reach the target tissue by itself. Thus, the precise transport of miRNA to the target sites is key to the success of gene therapy. Herein, we selected a miRNA, namely miR-21-5p, based on its unique intraocular pressure (IOP) mechano-sensing property. Moreover, a biocompatible polymeric poly(L-lysine) (PLL) micelle conjugated with collagenase and ABCA1 antibody was judiciously constructed to achieve the trans-corneal and target delivery of miR-21-5p to the trabecular meshwork (TM) and Schlemm's canal (SC) tissues inside the eye. The topically administrated PLL micelles as an eye drop successfully crossed the cornea with the help of collagenase and then preferentially accumulated in the target TM/SC tissues under the guidance of the ABCA1 antibody. When endocytosed by TM/SC cells, the PLL micelles could be decomposed in the reductive lysosomal environment to release miR-21-5p for successfully lowering the IOP by activating the miR-21-5p/eNOS/MMP9 signaling axis, which will open new prospects for glaucoma-specific gene therapy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 43","pages":" 10433-10445"},"PeriodicalIF":7.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54232953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallium-based metal–organic frameworks loaded with antimicrobial peptides for synergistic killing of drug-resistant bacteria† 镓基金属有机框架，负载抗菌肽，协同杀灭耐药细菌。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-12 DOI: 10.1039/D3TB01754K

Shuo Liu, Yuxin Ji, Hangqi Zhu, Zhishang Shi, Mingchun Li and Qilin Yu

{"title":"Gallium-based metal–organic frameworks loaded with antimicrobial peptides for synergistic killing of drug-resistant bacteria†","authors":"Shuo Liu, Yuxin Ji, Hangqi Zhu, Zhishang Shi, Mingchun Li and Qilin Yu","doi":"10.1039/D3TB01754K","DOIUrl":"10.1039/D3TB01754K","url":null,"abstract":"Increased antibiotic resistance has made bacterial infections a global concern, which requires novel non-antibiotic-dependent antibacterial strategies to address the menace. Antimicrobial peptides (AMPs) are a promising antibiotic alternative, whose antibacterial mechanism is mainly to destroy the membrane of bacteria. Gallium ions exhibit an antibacterial effect by interfering with the iron metabolism of bacteria. With the rapid development of nanotechnology, it is worth studying the potential of gallium-AMP-based nanocomposites for treating bacterial infections. Herein, novel gallium-based metal–organic frameworks (MOFs) were synthesized at room temperature, followed by in situ loading of the model AMP melittin. The obtained nanocomposites exhibited stronger antibacterial activity than pure MEL and gallium ions, achieving the effects of “one plus one is greater than two”. Moreover, the nanocomposites showed favorable biocompatibility and accelerated healing of a wound infected by methicillin-resistant Staphylococcus aureus by down-regulation of inflammatory cytokines IL-6 and TNF-α. This work presents an innovative antibacterial strategy to overcome the antibiotic resistance crisis and expand the application of AMPs.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 43","pages":" 10446-10454"},"PeriodicalIF":7.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54232952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High strength, self-healing sensitive ionogel sensor based on MXene/ionic liquid synergistic conductive network for human-motion detection† 基于MXene/离子液体协同导电网络的高强度、自修复敏感离子凝胶传感器，用于人体运动检测。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-12 DOI: 10.1039/D3TB01570J

Xiao Wen, Zhipeng Deng, Hui Wang, Jianyang Shi, Shuang Wang, Haibo Wang, Yueming Song, Zongliang Du, Jinghong Qiu and Xu Cheng

{"title":"High strength, self-healing sensitive ionogel sensor based on MXene/ionic liquid synergistic conductive network for human-motion detection†","authors":"Xiao Wen, Zhipeng Deng, Hui Wang, Jianyang Shi, Shuang Wang, Haibo Wang, Yueming Song, Zongliang Du, Jinghong Qiu and Xu Cheng","doi":"10.1039/D3TB01570J","DOIUrl":"10.1039/D3TB01570J","url":null,"abstract":"Ionogels with both high strength and high conductivity for wearable strain and pressure dual-mode sensors are needed for human motion and health monitoring. Here, multiple hydrogen bonds are introduced through imidazolidinyl urea (IU) as a chain extender to provide high mechanical and self-healing properties for the water–borne polyurethane (WPU). The MXene/ionic liquids synergistic conductive network provides excellent conductivity and also reduces the relative content of ionic liquids to maintain the mechanical properties of the ionogels. The mechanical strength of this ionogel reached 1.81–2.24 MPa and elongation at break reached 570–624%. It also has excellent conductivity (22.7–37.5 mS m−1), gauge factor (GF) (as a strain sensor, GF = 1.8), sensitivity (S) (as a press sensor, S1 = 29.8 kPa−1, S2 = 1.3 kPa−1), and fast response time (as a strain sensor = 185 ms; as a press sensor = 204 ms). The ionogel also exhibits rapid photothermal self-healing capabilities due to the inherent photothermal behavior of MXene. It can maintain good elasticity and conductivity at low temperatures. In addition, this ionogel is able to stretch for 1200 cycles without significant change in the relative change of resistance. The ionogel can be assembled as a strain sensor for monitoring human motion and as a pressure sensor array for obtaining pressure magnitude and position information.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 47","pages":" 11251-11264"},"PeriodicalIF":7.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbohydrate–protein interaction-based detection of pathogenic bacteria using a biodegradable self-powered biosensor† 使用可生物降解的自供电生物传感器进行基于碳水化合物-蛋白质相互作用的致病菌检测。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-11 DOI: 10.1039/D3TB01820B

Swati Panda, Sugato Hajra, Hang Gyeom Kim, Haejin Jeong, P. G. R. Achary, Seonki Hong, Bhaskar Dudem, S. Ravi P. Silva, Venkateswaran Vivekananthan and Hoe Joon Kim

{"title":"Carbohydrate–protein interaction-based detection of pathogenic bacteria using a biodegradable self-powered biosensor†","authors":"Swati Panda, Sugato Hajra, Hang Gyeom Kim, Haejin Jeong, P. G. R. Achary, Seonki Hong, Bhaskar Dudem, S. Ravi P. Silva, Venkateswaran Vivekananthan and Hoe Joon Kim","doi":"10.1039/D3TB01820B","DOIUrl":"10.1039/D3TB01820B","url":null,"abstract":"Battery-free and biodegradable sensors can detect biological elements in remote areas. The triboelectric nanogenerator (TENG) can potentially eliminate the need for a battery by simply converting the abundant vibrations from nature or human motion into electricity. A biodegradable sensor system integrated with TENG to detect commonly found disease-causing bacteria (E. coli) in the environment is showcased herein. In this system, D-mannose functionalized 3D printed polylactic acid (PLA) with the brush-painted silver electrode was used to detect E. coli by a simple carbohydrate–protein interaction mechanism. The adsorption capacity of D-mannose is generally altered by varying the concentration of E. coli resulting in changes in resistance. Thus, the presented biosensor can detect bacterial concentrations by monitoring the output current. The PLA TENG generates an output of 70 V, 800 nA, and 22 nC, respectively. In addition, tap water and unpasteurized milk samples are tested for detecting bacteria, and the output is measured at 6 μA and 5 μA, respectively. Further, the biosensor was tested for biodegradability in soil compost by maintaining constant temperature and humidity. This study not only proposes an efficient and fast method for screening E. coli but also gives important insights into the ability to degrade and long-term reliability of TENG-based sensor platforms.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 42","pages":" 10147-10157"},"PeriodicalIF":7.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible electrochemical sensor for highly sensitive and selective non-enzymatic detection of creatinine via electrodeposited copper over polymelamine formaldehyde† 柔性电化学传感器高灵敏度和选择性非酶检测肌酐通过电沉积铜在聚三聚氰胺甲醛。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-11 DOI: 10.1039/D3TB01528A

Daisy Mehta, Alankar Kafle and Tharamani C. Nagaiah

{"title":"Flexible electrochemical sensor for highly sensitive and selective non-enzymatic detection of creatinine via electrodeposited copper over polymelamine formaldehyde†","authors":"Daisy Mehta, Alankar Kafle and Tharamani C. Nagaiah","doi":"10.1039/D3TB01528A","DOIUrl":"10.1039/D3TB01528A","url":null,"abstract":"A non-enzymatic electrochemical biosensor was developed for highly sensitive detection of creatinine using copper nanoparticles supported over polymelamine formaldehyde. The synergy between the electrodeposited copper nanoparticles over the highly porous polymer (eCu-PMF) provided a greener platform to boost up the electron transport at the electrode electrolyte interface by eliminating the role of redox species as well as interference of major interferents like glucose, dopamine, and ascorbic acid in physiological media 0.1 M PBS (pH 7.4). The proposed sensor exhibited a wide detection range of 100 fM–60 mM with high sensitivities of 0.320 mA nM−1 cm−2 and 3.8 mA nM−1 cm−2. Moreover, the sensor was applied to real samples of serum creatinine and recoveries of 97 to 114% were found. Additionally, a paper-based flexible screen-printed electrode was fabricated which displayed an excellent activity with the same detection range of 100 fM–60 mM and long-term storage stability of 15 days.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 46","pages":" 11103-11109"},"PeriodicalIF":7.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphatidylserine-functionalized liposomes-in-microgels for delivering genistein to effectively treat ulcerative colitis† 磷脂酰丝氨酸功能化脂质体微凝胶递送染料木素有效治疗溃疡性结肠炎。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-10-11 DOI: 10.1039/D3TB00812F

Huijia Yan, Yanfei Li, Sihui Li, Di Wu, Yu Xu and Jiangning Hu

{"title":"Phosphatidylserine-functionalized liposomes-in-microgels for delivering genistein to effectively treat ulcerative colitis†","authors":"Huijia Yan, Yanfei Li, Sihui Li, Di Wu, Yu Xu and Jiangning Hu","doi":"10.1039/D3TB00812F","DOIUrl":"10.1039/D3TB00812F","url":null,"abstract":"Ulcerative colitis (UC) is an inflammatory disease involving ulcers in the colon and rectum. The conventional treatments for UC still have many limitations, such as non-specific release, adverse effects and low absorption, resulting in the poor bioavailability of therapeutic agents. To address these challenges, targeting delivery systems are required to specifically deliver drugs to the colonic site with controlled release. Herein, we present a novel microgel oral delivery system, loaded with liposome nanoparticles (Li NPs) containing a natural anti-inflammatory compound genistein (Gen) into alginate microgels, thereby achieving the targeted release of Gen in the colonic region and ameliorating UC symptoms. Initially, Gen was loaded into phosphatidylserine (PS)-functionalized Li NPs to form Gen@Li NPs with an average size of 245.9 ± 9.6 nm. In vitro assessments confirmed that Gen@Li NPs efficiently targeted macrophages and facilitated the internalization of Gen into cells. To prevent rapid degradation in the harsh gastrointestinal tract, Gen@Li NPs were further encapsulated into alginate microgels through electric spraying technology, forming Gen@Li microgels. In vivo distribution tests demonstrated that Gen@Li microgels possessed long-term retention in the colon and gradual release characteristics compared to Gen@Li NPs. Furthermore, in vivo experiments confirmed that Gen@Li microgels significantly alleviated UC symptoms in mice induced by dextran sulfate sodium salt (DSS) mainly through reducing the expression levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) and promoting colonic mucosal barrier repair through upregulation of mucosal protein expression. This study shed light on the potential of utilizing oral administration of natural compounds for UC treatment.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 43","pages":" 10404-10417"},"PeriodicalIF":7.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0