Journal of Materials Chemistry B最新文献_第4页

Atomically dispersed single-atom catalysts (SACs) and enzymes (SAzymes): synthesis and application in Alzheimer's disease detection 原子分散单原子催化剂（SACs）和酶（SAzymes）：合成及在阿尔茨海默病检测中的应用

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-03 DOI: 10.1039/d4tb01293c

Himanshi Goel, Ishika Rana, Kajal Jain, Kumar Rakesh Ranjan, Vivek Mishra

{"title":"Atomically dispersed single-atom catalysts (SACs) and enzymes (SAzymes): synthesis and application in Alzheimer's disease detection","authors":"Himanshi Goel, Ishika Rana, Kajal Jain, Kumar Rakesh Ranjan, Vivek Mishra","doi":"10.1039/d4tb01293c","DOIUrl":"https://doi.org/10.1039/d4tb01293c","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Conventional diagnostic methods, such as neuroimaging and cerebrospinal fluid analysis, typically detect AD at advanced stages, limiting the efficacy of therapeutic interventions. Early detection is crucial for improving patient condition by enabling timely administration of treatments that may decelerate disease progression. In this context, single-atom catalysts (SACs) and single-atom nanozymes (SAzymes) have emerged as promising tools offering highly sensitive and selective detection of Alzheimer's biomarkers. SACs, consisting of isolated metal atoms on a support surface, deliver unparalleled atomic efficiency, increased reactivity, and reduced operational costs, although certain challenges in terms of stability, aggregation, and other factors persist. The advent of SAzymes, which integrate SACs with natural metalloprotease catalysts, has further advanced this field by enabling controlled electronic exchange, synergistic productivity, and enhanced biosafety. Particularly, M–N–C SACs with M–Nx active sites mimic the selectivity and sensitivity of natural metalloenzymes, providing a robust platform for early detection of AD. This review encompasses the advancements in SACs and SAzymes, highlighting their pivotal role in bridging the gap between conventional enzymes and nanozyme and offering enhanced catalytic efficiency, controlled electron transfer, and improved biosafety for Alzheimer's detection.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface modification of medical grade biomaterials by using a low-temperature-processed dual functional Ag–TiO2 coating for preventing biofilm formation 利用低温加工的 Ag-TiO2 双功能涂层对医用生物材料进行表面改性，以防止生物膜的形成

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-02 DOI: 10.1039/d4tb00701h

Lipi Pradhan, Sobhan Hazra, Satya Veer Singh, Bajrang, Anjali Upadhyay, Bhola Nath Pal, Sudip Mukherjee

{"title":"Surface modification of medical grade biomaterials by using a low-temperature-processed dual functional Ag–TiO2 coating for preventing biofilm formation","authors":"Lipi Pradhan, Sobhan Hazra, Satya Veer Singh, Bajrang, Anjali Upadhyay, Bhola Nath Pal, Sudip Mukherjee","doi":"10.1039/d4tb00701h","DOIUrl":"https://doi.org/10.1039/d4tb00701h","url":null,"abstract":"Biofilm development in medical devices is considered the major virulence component that leads to increased mortality and morbidity among patients. Removing a biofilm once formed is challenging and frequently results in persistent infections. Many current antibiofilm coating strategies involve harsh conditions causing damage to the surface of the medical devices. To address the issue of bacterial attachment in medical devices, we propose a novel antibacterial surface modification approach. In this paper, we developed a novel low-temperature based solution-processed approach to deposit silver nanoparticles (Ag NPs) inside a titanium oxide (TiO2) matrix to obtain a Ag–TiO2 nanoparticle coating. The low temperature (120 °C)-based UV annealed drop cast method is novel and ensures no surface damage to the medical devices. Various medical-grade biomaterials were then coated using Ag–TiO2 to modify the surface of the materials. Several studies were performed to observe the antibacterial and antibiofilm properties of Ag–TiO2-coated medical devices and biomaterials. Moreover, the Ag–TiO2 NPs did not show any skin irritation in rats and showed biocompatibility in the chicken egg model. This study indicates that Ag–TiO2 coating has promising potential for healthcare applications to combat microbial infection and biofilm formation.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ni@TiO2 nanoribbon array electrode for high-efficiency non-enzymatic glucose biosensing† 用于高效非酶切葡萄糖生物传感的 Ni@TiO2 纳米带阵列电极。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-02 DOI: 10.1039/D4TB01721H

Peilin Wu, Jianying Yang, Yunze Tai, Xun He, Limei Zhang, Jiwen Fan, Yongchao Yao, Binwu Ying, Wenchuang (Walter) Hu, Fengming Luo, Xuping Sun and Yi Li

引用次数: 0

Recent development and applications of electrodeposition biocoatings on medical titanium for bone repair 用于骨修复的医用钛电沉积生物涂层的最新发展和应用

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-02 DOI: 10.1039/d4tb01081g

Jialong Yi, Ming Li, Jixiang Zhu, ZuHang Wang, Xiaoyan Li

{"title":"Recent development and applications of electrodeposition biocoatings on medical titanium for bone repair","authors":"Jialong Yi, Ming Li, Jixiang Zhu, ZuHang Wang, Xiaoyan Li","doi":"10.1039/d4tb01081g","DOIUrl":"https://doi.org/10.1039/d4tb01081g","url":null,"abstract":"Bioactive coatings play a crucial role in enhancing the osseointegration of titanium implants for bone repair. Electrodeposition offers a versatile and efficient technique to deposit uniform coatings onto titanium surfaces, endowing implants with antibacterial properties, controlled drug release, enhanced osteoblast adhesion, and even smart responsiveness. This review summarizes the recent advancements in bioactive coatings for titanium implants used in bone repair, focusing on various electrodeposition strategies based on material-structure synergy. Firstly, it outlines different titanium implant materials and bioactive coating materials suitable for bone repair. Then, it introduces various electrodeposition methods, including electrophoretic deposition, anodization, micro-arc oxidation, electrochemical etching, electrochemical polymerization, and electrochemical deposition, discussing their applications in antibacterial, osteogenic, drug delivery, and smart responsiveness. Finally, it discusses the challenges encountered in the electrodeposition of coatings for titanium implants in bone repair and potential solutions.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alleviating hypoxia and oxidative stress for treatment of cardiovascular diseases: a biomaterials perspective 缓解缺氧和氧化应激以治疗心血管疾病：生物材料的视角

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-08-29 DOI: 10.1039/d4tb01126k

Durga Nandini Athmuri, Jayanta Bhattacharyya, Naresh Bhatnagar, Parvaiz Ahmad Shiekh

{"title":"Alleviating hypoxia and oxidative stress for treatment of cardiovascular diseases: a biomaterials perspective","authors":"Durga Nandini Athmuri, Jayanta Bhattacharyya, Naresh Bhatnagar, Parvaiz Ahmad Shiekh","doi":"10.1039/d4tb01126k","DOIUrl":"https://doi.org/10.1039/d4tb01126k","url":null,"abstract":"A state of hypoxia (lack of oxygen) persists in the initial and later phases of healing in cardiovascular diseases, which can alter the tissue's repair or regeneration, ultimately affecting the structure and functionality of the related organ. Consequently, this results in a cascade of events, leading to metabolic stress and the production of reactive oxygen species (ROS) and autophagy. This unwanted situation not only limits the oxygen supply to the needy tissues but also creates an inflammatory state, limiting the exchange of nutrients and other supplements. Consequently, biomaterials have gained considerable attention to alleviate hypoxia and oxidative stress in cardiovascular diseases. Numerous oxygen releasing and antioxidant biomaterials have been developed and proven to alleviate hypoxia and oxidative stress. This review article summarizes the mechanisms involved in cardiovascular pathologies due to hypoxia and oxidative stress, as well as the treatment modalities currently in practice. The applications, benefits and possible shortcomings of these approaches have been discussed. Additionally, the review explores the role of novel biomaterials in combating the limitations of existing approaches, primarily focusing on the development of oxygen-releasing and antioxidant biomaterials for cardiac repair and regeneration. It also directs attention to various other potential applications with critical insights for further advancement in this area.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing/electrospinning of a bilayered composite patch with antibacterial and antiadhesive properties for repairing abdominal wall defects 用于修复腹壁缺损的具有抗菌和抗粘连特性的双层复合补片的三维打印/电纺丝技术

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-08-28 DOI: 10.1039/d4tb01543f

Qingxi Hu, Yu Zhang, Yongteng Song, Hekai Shi, Dongchao Yang, Haiguang Zhang, Yan Gu

{"title":"3D printing/electrospinning of a bilayered composite patch with antibacterial and antiadhesive properties for repairing abdominal wall defects","authors":"Qingxi Hu, Yu Zhang, Yongteng Song, Hekai Shi, Dongchao Yang, Haiguang Zhang, Yan Gu","doi":"10.1039/d4tb01543f","DOIUrl":"https://doi.org/10.1039/d4tb01543f","url":null,"abstract":"The application of patch methods for repairing abdominal wall wounds presents a variety of challenges, such as adhesion and limited mobility due to inadequate mechanical strength and nonabsorbable materials. Among these complications, postoperative visceral adhesion and wound infection are particularly serious. In this study, a bilayered composite patch with a gelatin methacryloyl (GelMA)/sodium alginate (SA)-vancomycin (Van)@polycaprolactone (PCL) (GelMA/SA-Van@PCL) antibacterial layer was prepared via coaxial 3D printing and a polycaprolactone (PCL)-silicon dioxide (SiO2) antiadhesive layer (PCL-SiO2) was prepared via electrospinning and electrostatic spray for hernia repair. The evaluation of the physicochemical properties revealed that the composite patch had outstanding tensile properties (16 N cm−1), excellent swelling (swelling rate of 243.81 ± 12.52%) and degradation (degradation rate of 53.14 ± 3.02%) properties. Furthermore, the composite patch containing the antibiotic Van exhibited good antibacterial and long-term drug release properties. Both in vivo and in vitro experiments indicated that the composite patch displayed outstanding biocompatibility and antiadhesive properties and could prevent postoperative infections. In summary, the bilayered composite patch can effectively prevent postoperative complications while promoting tissue growth and repair and holds significant application potential in hernia repair.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous assembly of a class of small molecule prodrugs directed by SN38 由 SN38 引导的一类小分子原药的自发组装

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-08-28 DOI: 10.1039/d4tb01429d

Zhenhai Tang, Wenning Lan, Kaiying Wen, Wenting Li, Tao Wang, Dongdong Zhou, Hao Su

{"title":"Spontaneous assembly of a class of small molecule prodrugs directed by SN38","authors":"Zhenhai Tang, Wenning Lan, Kaiying Wen, Wenting Li, Tao Wang, Dongdong Zhou, Hao Su","doi":"10.1039/d4tb01429d","DOIUrl":"https://doi.org/10.1039/d4tb01429d","url":null,"abstract":"Small molecule self-assembling prodrugs (SAPDs) are an emerging class of amphiphilic monomers that can aggregate into supramolecular nanostructures with high drug loading identical to that of the individual prodrug. Despite great progress in creating nanodrugs via nanoprecipitation, the direct self-assembly of small molecule SAPDs in aqueous solution remains challenging, as the proper hydrophilic–hydrophobic balance and intermolecular interactions have to be rationally considered. We report a class of small molecule SAPDs by conjugating the anticancer drug SN38 as the structure-directing component with various hydrophilic auxiliaries (i.e., oligo ethylene glycol (OEG) of different lengths, amino, and carboxyl groups) via a self-immolative disulfanyl-ethyl carbonate linker. Driven by π–π interactions between SN38 units, these SAPDs spontaneously assembled into well-defined fibrous nanostructures. Variations in hydrophilic domains can robustly regulate the hydrophobicity of SAPDs, as well as the morphologies and surface features of supramolecular filaments, subsequently influencing cellular internalization behaviors. Furthermore, our study also reveals that the parent drug can be efficiently and controllably released in the presence of glutathione (GSH), exhibiting high in vitro toxicity against colorectal cancer cells. In this work, we present a delicate platform to design small molecule SAPDs that can spontaneously self-assemble into supramolecular filamentous assemblies directed by aromatic interaction of the parent drugs, providing a new strategy to optimize supramolecular drug delivery systems.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing the capture efficiency of ultrasensitive digital ELISA via an antibody oriented-immobilization strategy 通过抗体定向固定策略革新超灵敏数字酶联免疫吸附试验的捕获效率

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-08-28 DOI: 10.1039/d4tb01141d

Yutong Zhang, Xiaojun Kuang, Jingwei Yi, Tong Sun, Qingsheng Guo, Hongchen Gu, Hong Xu

{"title":"Revolutionizing the capture efficiency of ultrasensitive digital ELISA via an antibody oriented-immobilization strategy","authors":"Yutong Zhang, Xiaojun Kuang, Jingwei Yi, Tong Sun, Qingsheng Guo, Hongchen Gu, Hong Xu","doi":"10.1039/d4tb01141d","DOIUrl":"https://doi.org/10.1039/d4tb01141d","url":null,"abstract":"Bead-based digital ELISA, the most sensitive protein quantification method, has drawn much attention to exploring ultra-low abundance biomarkers in the life sciences and clinical applications. However, its major challenge refers to the low antigen capture efficiency in the immunoreaction process due to the low probability of collision between the deficient concentration of the analytes and the captured antibody-immobilized on the beads. Here, we achieved significantly improved reaction efficiency in the digital signal formation by fixing the orientation of antibodies and revealed the kinetic mechanism for the first time. A facile and fast antibody conjugation strategy that formed boronate ester complexes was designed to retain the uniform orientation of antibodies with controllable antibody density. Remarkably, the oriented immobilized antibody exhibited stronger antigen-binding capacity and faster antigen-binding speed compared to randomly immobilized antibodies, with capture efficiency increasing approximately 14-fold at 15 μg of antibody per 1 mg microbeads (0.035 antibody nm−2) under 0.5 h incubation. Combined with theoretical analysis, we verified that the improved capture efficiency of the oriented antibodies mainly originated from the considerable rise in the binding rate constant (kon) rather than the increase in antigen-binding sites, which further prominently decreased the limit of detection (LoD) in a shorter incubation time compared with the randomly immobilized antibody. In conclusion, the antibody oriented conjugation method effectively overcomes the low capture efficiency challenge of bead-based digital ELISA. It paves a promising way for further improving the digital immunoassay performance and promotes the early diagnosis of diseases by recognizing more ultra-low abundance significant biomarkers.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing 藻酸钠敷料在糖尿病伤口愈合中靶向给药的最新进展

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-08-27 DOI: 10.1039/d4tb01049c

Mohammad Ebrahim Astaneh, Alireza Hashemzadeh, Narges Fereydouni

引用次数: 0

An intelligent NIR-IIb-responsive lanthanide@metal–organic framework core–shell nanocatalyst for combined deep-tumor therapy† 用于深部肿瘤联合治疗的智能近红外-IIb 响应镧系@金属有机框架核壳纳米催化剂。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-08-27 DOI: 10.1039/D4TB01321B

Chaoqun Jiang, Yu Chen, Xiaolong Li and Youbin Li

{"title":"An intelligent NIR-IIb-responsive lanthanide@metal–organic framework core–shell nanocatalyst for combined deep-tumor therapy†","authors":"Chaoqun Jiang, Yu Chen, Xiaolong Li and Youbin Li","doi":"10.1039/D4TB01321B","DOIUrl":"10.1039/D4TB01321B","url":null,"abstract":"The ground-breaking combination of photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted much attention in medical fields as an effective method for fighting cancer. However, evidence suggests that the therapy efficiency is still limited by shallow light penetration depth and poor photosensitizer loading capacity. Herein, we constructed an upconversion nanoparticle@Zr-based metal–organic framework@indocyanine green molecule (UCNPs@ZrMOF@ICG) nanocomposite to integrate 1532 nm light-triggered PDT and 808 nm light-mediated PTT. NaLnF4 nanoparticles are designed to emit upconversion luminescence (UCL) under 1532 nm laser excitation, which is consistent with the absorption spectra of the ZrMOF. Benefiting from the excellent energy transfer efficiency, the ZrMOF can absorb visible light from the UCNPs and then catalyze O2 into 1O2 for deep tissue PDT. To achieve combination therapy, the clinically approved ICG nanocomposite was introduced as a photothermal agent for PTT under 808 nm laser irradiation, and the photothermal conversion efficiency was calculated to be ∼28%. The designed nanosystems facilitate efficient deep-tissue tumor treatment by integrating PDT with PTT. Ultimately, this study creates a multifunctional nanocomposite by combining 1532 nm light-triggered deep tissue PDT and near-infrared (NIR) light-driven PTT for personalized cancer therapy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0